Preparation method of polyethylene glycol 4000 electrolyte powder

Abstract

The invention provides a preparation method of polyethylene glycol 4000 electrolyte powder, and particularly relates to the field of medicines. 50-70 g of potassium chloride, 110-120 g of sodium chloride and 130-140 g of sodium bicarbonate are taken and placed in a 2L pot body of a hopper mixer, the mixing rotating speed is 10-20 rpm, and the mixing time is 8-12 min; sieving the mixed materials through a 120-mesh sieve to obtain a mixture 1; adding 440-460g of anhydrous sodium sulfate and the mixture 1 into a 2L pot body of a hopper mixer, wherein the mixing rotating speed is 10-20rpm, and the mixing time is 8-12min; sieving with a 120-mesh sieve to obtain a mixture 2; adding 750-850g of polyethylene glycol 4000 and the mixture 2, and placing the mixture 2 and the polyethylene glycol 4000 in a 15L pot body of a three-dimensional mixer for mixing for 8-12 minutes to obtain a mixture 3; adding 1450-1550g of polyethylene glycol 4000 and the mixture 3 into a 15L pot body of a three-dimensional mixer, and mixing for 10-20 minutes to obtain a mixture 4; and adding 2800-3000g of polyethylene glycol 4000 and the mixture 4 into a 15L pot body of a three-dimensional mixer, and mixing for 10-20 minutes to obtain the target product. According to the invention, the problem of poor bulk mixing uniformity of the polyethylene glycol 4000 electrolyte can be solved.

Description

Technical Field

[0001] The present invention belongs to the field of medicine, and particularly relates to a preparation method of polyethylene glycol 4000 electrolyte powder Background Art

[0002] Polyethylene glycol 4000 electrolyte powder is a white waxy solid thin slice or granular powder. It is readily soluble in water or ethanol and insoluble in ether. By hydrogen bonding to fix water molecules, water is retained in the colon, increasing the water content of feces and softening feces, restoring the volume and weight of feces to normal, and promoting the final completion of defecation, thereby improving constipation symptoms. In the preparation of existing polyethylene glycol 4000 electrolyte powder, the uniformity of the finished product prepared by the existing process still needs to be improved Summary of the Invention

[0003] The purpose of the present invention is to provide a preparation method of polyethylene glycol 4000 electrolyte powder, which can solve the problem of poor mixing uniformity of polyethylene glycol 4000 electrolyte powder

[0004] The present invention provides the following technical solutions

[0005] A preparation method of polyethylene glycol 4000 electrolyte powder, comprising the following steps

[0006] S1. Sodium chloride, potassium chloride, sodium bicarbonate, and anhydrous sodium sulfate are respectively crushed and sieved through a 150-mesh sieve

[0007] The particle size D90 of the material sodium chloride is 80μm - 90μm, the particle size D90 of potassium chloride is 80μm - 90μm, the particle size D90 of sodium bicarbonate is 80μm - 90μm, and the particle size D90 of anhydrous sodium sulfate is 80μm - 90μm

[0008] Polyethylene glycol 4000 is crushed and sieved through a 60-mesh sieve, and the particle size D90 is 220μm - 230μm

[0009] S2. Take 50 - 70g of potassium chloride, 110 - 120g of sodium chloride, and 130 - 140g of sodium bicarbonate and place them in the hopper mixer in a 2L pot body. The mixing speed is 10 - 20rpm, and the mixing time is 8 - 12min; the mixed material is sieved through a 120-mesh sieve to obtain mixture 1

[0010] S3. Add 440 - 460g of anhydrous sodium sulfate and mixture 1 into the hopper mixer in a 2L pot body. The mixing speed is 10 - 20rpm, and the mixing time is 8 - 12min; then it is sieved through a 120-mesh sieve to obtain mixture 2

[0011] S4. Add 750 - 850g of polyethylene glycol 4000 and mixture 2 into a three-dimensional mixer in a 15L pot body, and the mixing time is 8 - 12min to obtain mixture 3

[0012] S5. Add 1450 - 1550 g of polyethylene glycol 4000 and the mixture 3 into a three - dimensional mixer: in a 15 L pot body, mixing time: 10 - 20 min, to obtain mixture 4;

[0013] S6. Add 2800 - 3000 g of polyethylene glycol 4000 and the mixture 4 into a three - dimensional mixer: in a 15 L pot body, mixing time: 10 - 20 min, then the target product is obtained.

[0014] Preferably, in step S1, the particle size D90 of sodium chloride is 85 μm, the particle size D90 of potassium chloride is 85 μm, the particle size D90 of sodium bicarbonate is 85 μm, and the particle size D90 of anhydrous sodium sulfate is 85 μm; the particle size D90 of polyethylene glycol 4000 after crushing and sieving through 60 - mesh is 85 μm.

[0015] Preferably, in step S2, take 60 g of potassium chloride, 116.85 g of sodium chloride, and 134.47 g of sodium bicarbonate and place them in a 2 L pot body of a hopper mixer, mixing speed: 15 rpm, mixing time: 10 min.

[0016] Preferably, in step S3, add 456 g of anhydrous sodium sulfate and the mixture 1 into a 2 L pot body of a hopper mixer, mixing speed: 15 rpm, mixing time: 10 min.

[0017] Preferably, in step S4, add 800 g of polyethylene glycol 4000 and the mixture 2 into a three - dimensional mixer: in a 15 L pot body, mixing time: 10 min.

[0018] Preferably, in step S5, add 1500 g of polyethylene glycol 4000 and the mixture 3 into a three - dimensional mixer: in a 15 L pot body, mixing time: 15 min.

[0019] Preferably, in step S6, add 2840 g of polyethylene glycol 4000 and the mixture 4 into a three - dimensional mixer: in a 15 L pot body, mixing time: 15 min.

[0020] Advantages of the present invention:

[0021] The present invention solves the problem of poor mixing uniformity of polyethylene glycol 4000 electrolyte powder prepared by the existing preparation method through the synergistic control of the particle sizes of inorganic salts and polyethylene glycol 4000 in the prescription. Detailed implementation manners

[0022] Example 1:

[0023] A preparation method of polyethylene glycol 4000 electrolyte powder, comprising the following steps:

[0024] S1. Sodium chloride, potassium chloride, sodium bicarbonate, and anhydrous sodium sulfate are respectively pulverized and sieved through a 150-mesh sieve;

[0025] The particle size D90 of the material sodium chloride is 80 μm, the particle size D90 of potassium chloride is 80 μm, the particle size D90 of sodium bicarbonate is 80 μm, and the particle size D90 of anhydrous sodium sulfate is 80 μm;

[0026] Polyethylene glycol 4000 is pulverized and sieved through a 60-mesh sieve, and the particle size D90 is 220 μm;

[0027] S2. Take 50 g of potassium chloride, 110 g of sodium chloride, and 130 g of sodium bicarbonate and place them in the hopper mixer in a 2-L pot body. Mixing speed: 10 rpm, mixing time: 8 min; the mixed material is sieved through a 120-mesh sieve to obtain mixture 1;

[0028] S3. Add 440 g of anhydrous sodium sulfate and mixture 1 to the hopper mixer in a 2-L pot body. Mixing speed: 10 rpm, mixing time: 8 min; then sieved through a 120-mesh sieve to obtain mixture 2;

[0029] S4. Add 750 - 850 g of polyethylene glycol 4000 and mixture 2 to a three-dimensional mixer: in a 15-L pot body, mixing time: 8 min, to obtain mixture 3;

[0030] S5. Add 1450 g of polyethylene glycol 4000 and mixture 3 to a three-dimensional mixer: in a 15-L pot body, mixing time: 10 min, to obtain mixture 4;

[0031] S6. Add 2800 g of polyethylene glycol 4000 and mixture 4 to a three-dimensional mixer: in a 15-L pot body, mixing time: 10 min, to obtain the target product.

[0032] Take 12 samples of the product prepared in Example 1, numbered 1a - 12a respectively, and the test data are as follows:

[0033]

[0034]

[0035] Example 2:

[0036] A preparation method of polyethylene glycol 4000 electrolyte powder, comprising the following steps:

[0037] S1. Sodium chloride, potassium chloride, sodium bicarbonate, and anhydrous sodium sulfate are respectively pulverized and sieved through a 150-mesh sieve;

[0038] The particle size D90 of the material sodium chloride is 85 μm, the particle size D90 of potassium chloride is 85 μm, the particle size D90 of sodium bicarbonate is 85 μm, and the particle size D90 of anhydrous sodium sulfate is 85 μm;

[0039] Polyethylene glycol 4000 is pulverized and sieved through a 60-mesh sieve, and the particle size D90 is 85 μm;

[0040] S2. Take 60 g of potassium chloride, 116.85 g of sodium chloride, and 134.47 g of sodium bicarbonate and place them in the 2L pot body of the hopper mixer. Mixing speed: 15 rpm, mixing time: 10 min; the mixed material is sieved through a 120-mesh sieve to obtain mixture 1;

[0041] S3. Add 456 g of anhydrous sodium sulfate and mixture 1 to the 2L pot body of the hopper mixer. Mixing speed: 15 rpm, mixing time: 10 min; then sieve through a 120-mesh sieve to obtain mixture 2;

[0042] S4. Add 800 g of polyethylene glycol 4000 and mixture 2 to the three-dimensional mixer: in the 15L pot body, mixing time: 10 min, to obtain mixture 3;

[0043] S5. Add 1500 g of polyethylene glycol 4000 and mixture 3 to the three-dimensional mixer: in the 15L pot body, mixing time: 15 min, to obtain mixture 4;

[0044] S6. Add 2840 g of polyethylene glycol 4000 and mixture 4 to the three-dimensional mixer: in the 15L pot body, mixing time: 15 min, to obtain the target product.

[0045] Take 12 samples of the product prepared in Example 2, numbered 1b - 12b respectively, and the test data are as follows:

[0046]

[0047]

[0048] Example 3:

[0049] A preparation method of polyethylene glycol 4000 electrolyte powder, comprising the following steps:

[0050] S1. Sodium chloride, potassium chloride, sodium bicarbonate, and anhydrous sodium sulfate are respectively pulverized and sieved through a 150-mesh sieve;

[0051] The particle size D90 of the material sodium chloride is 90 μm, the particle size D90 of potassium chloride is 90 μm, the particle size D90 of sodium bicarbonate is 90 μm, and the particle size D90 of anhydrous sodium sulfate is 90 μm;

[0052] Polyethylene glycol 4000 is pulverized and sieved through a 60-mesh sieve, and the particle size D90 is 230 μm;

[0053] S2. Take 70 g of potassium chloride, 120 g of sodium chloride, and 140 g of sodium bicarbonate and place them in the hopper mixer in a 2 L pot body. Mixing speed: 20 rpm, mixing time: 12 min; after mixing, the material is sieved through a 120-mesh sieve to obtain mixture 1;

[0054] S3. Add 460 g of anhydrous sodium sulfate and mixture 1 to the hopper mixer in a 2 L pot body. Mixing speed: 20 rpm, mixing time: 12 min; then sieve through a 120-mesh sieve to obtain mixture 2;

[0055] S4. Add 850 g of polyethylene glycol 4000 and mixture 2 to a three-dimensional mixer in a 15 L pot body. Mixing time: 12 min to obtain mixture 3;

[0056] S5. Add 1550 g of polyethylene glycol 4000 and mixture 3 to a three-dimensional mixer in a 15 L pot body. Mixing time: 20 min to obtain mixture 4;

[0057] S6. Add 3000 g of polyethylene glycol 4000 and mixture 4 to a three-dimensional mixer in a 15 L pot body. Mixing time: 20 min to obtain the target product.

[0058] Take 12 samples of the product prepared in Example 3, numbered 1c - 12c respectively, and the test data are as follows:

[0059] Sampling Number Sodium Bicarbonate Total Chlorine Content Potassium Chloride 1c 97.81％ 98.57％ 99.59％ 2c 98.57％ 99.27％ 99.61％ 3c 97.70％ 98.79％ 101.97％ 4c 97.90％ 98.66％ 99.32％ 5c 98.30％ 98.42％ 100.29％ 6c 97.93％ 98.30％ 100.41％ 7c 98.25％ 98.77％ 100.83％ 8c 98.63％ 99.58％ 101.90％ 9c 99.20％ 99.31％ 99.94％ 10c 98.28％ 98.50％ 100.86％ 11c 99.49％ 100.00％ 102.80％ 12c 99.57％ 99.16％ 100.01％ Average Value 98.47％ 98.94％ 100.63％ RSD 0.65％ 0.53％ 1.08％

[0060] Control group experiment: Four groups of experiments, namely control group 1, control group 2, control group 3, and control group 4, were carried out using existing traditional technologies. The details are as follows:

[0061] Control group 1

[0062] Pretreatment: Sodium chloride, potassium chloride, and sodium bicarbonate are respectively crushed and sieved through a 60-mesh sieve, and anhydrous sodium sulfate is crushed and sieved through a 40-mesh sieve. The particle size D(90) of the material sodium chloride is 220 μm - 250 μm, the particle size D(90) of potassium chloride is 220 μm - 250 μm, the particle size D(90) of sodium bicarbonate is 220 μm - 250 μm, and the particle size D(90) of anhydrous sodium sulfate is 300 μm - 320 μm.

[0063] Step 1: Take 60 g of potassium chloride, 116.85 g of sodium chloride, 134.47 g of sodium bicarbonate, and 456 g of anhydrous sodium sulfate and place them in the hopper mixer in a 2 L pot body. Mixing speed: 15 rpm, mixing time: 10 min.

[0064] Step 2: Add 800 g of polyethylene glycol 4000 and Mixture 2 into a three-dimensional mixer: in a 15 L pot body, mixing speed: no speed, mixing time: 10 min.

[0065] Step 3: Add 1500 g of polyethylene glycol 4000 and Mixture 3 into a three-dimensional mixer: in a 15 L pot body, mixing speed: no speed, mixing time: 15 min.

[0066] Step 4: Add 2840 g of polyethylene glycol 4000 and Mixture 4 into a three-dimensional mixer: in a 15 L pot body, mixing speed: no speed, mixing time: 15 min to obtain a sample.

[0067] Take 12 samples of the product prepared in Control Group 1, numbered 1d - 12d respectively, and the test data are as follows:

[0068] Sampling Number Sodium Bicarbonate Total Chlorine Content Potassium Chloride 1d 99.35％ 101.17％ 100.98％ 2d 106.04％ 103.83％ 108.93％ 3d 89.67％ 95.78％ 93.46％ 4d 97.19％ 104.71％ 98.40％ 5d 102.19％ 102.88％ 103.98％ 6d 98.67％ 100.29％ 99.61％ 7d 95.82％ 96.45％ 95.30％ 8d 99.56％ 99.70％ 99.67％ 9d 96.45％ 95.25％ 95.35％ 10d 116.61％ 109.87％ 106.40％ 11d 98.14％ 99.99％ 98.67％ 12d 92.34％ 90.36％ 95.67％ Average Value 99.34％ 100.02％ 99.70％ RSD 6.93％ 5.13％ 4.75％

[0069] Control Group 2

[0070] Pretreatment: Crush and sieve sodium chloride, potassium chloride, and sodium bicarbonate through a 60 - mesh sieve, and crush and sieve anhydrous sodium sulfate through a 40 - mesh sieve. The particle size D(90) of the material sodium chloride: 220 μm - 250 μm, the particle size D(90) of potassium chloride: 220 μm - 250 μm, the particle size D(90) of sodium bicarbonate: 220 μm - 250 μm, and the particle size D(90) of anhydrous sodium sulfate: 300 μm - 320 μm.

[0071] Step 1: Take 60 g of potassium chloride, 116.85 g of sodium chloride, and 134.47 g of sodium bicarbonate and place them in a 2 L pot body of a hopper mixer, mixing speed: 15 rpm, mixing time: 10 min.

[0072] Step 2: Pass the mixed material through a 60 - mesh sieve.

[0073] Step 3: Add 456 g of anhydrous sodium sulfate and Mixture 1 into a 2 L pot body of a hopper mixer, mixing speed: 15 rpm, mixing time: 10 min.

[0074] Step 4: Pass through a 40 - mesh sieve.

[0075] Step 5: Add 800 g of polyethylene glycol 4000 and Mixture 2 into a three - dimensional mixer: in a 15 L pot body, mixing speed: no speed, mixing time: 10 min.

[0076] Step 6: Add 1500 g of polyethylene glycol 4000 and Mixture 3 into a three - dimensional mixer: in a 15 L pot body, mixing speed: no speed, mixing time: 15 min.

[0077] Step 7: Add 2840 g of polyethylene glycol 4000 and the mixture 4 into a three-dimensional mixer: in a 15 L pot body, mixing speed: no speed, mixing time: 15 min to obtain a sample.

[0078] Take 12 samples of the product prepared in Control Group 2, numbered 1e - 12e respectively, and the test data are as follows:

[0079] Sampling Number Sodium Bicarbonate Total Chlorine Content Potassium Chloride 1e 100.64％ 99.93％ 107.63％ 2e 99.87％ 98.24％ 99.83％ 3e 110.29％ 107.93％ 126.49％ 4e 99.46％ 100.30％ 105.51％ 5e 101.58％ 109.88％ 99.77％ 6e 108.71％ 98.35％ 100.86％ 7e 99.19％ 99.19％ 98.65％ 8e 101.17％ 98.24％ 105.39％ 9e 86.81％ 89.98％ 87.84％ 10e 105.64％ 99.09％ 99.44％ 11e 98.05％ 101.30％ 102.24％ 12e 95.63％ 97.38％ 98.64％ Average Value 100.59％ 99.98％ 102.69％ RSD 6.08％ 5.04％ 8.76％

[0080] Control Group 3

[0081] Pretreatment: Crush sodium chloride, potassium chloride, sodium bicarbonate, and anhydrous sodium sulfate and sieve them through a 100-mesh sieve. The particle size D(90) of the material sodium chloride: 130 μm - 150 μm, the particle size D(90) of potassium chloride: 130 μm - 150 μm, the particle size D(90) of sodium bicarbonate: 130 μm - 150 μm, and the particle size D(90) of anhydrous sodium sulfate: 130 μm - 150 μm.

[0082] Step 1: Take 60 g of potassium chloride, add 116.85 g of sodium chloride, and add 134.47 g of sodium bicarbonate into a hopper mixer with a 2 L pot body, mixing speed: 15 rpm, mixing time: 10 min.

[0083] Step 2: Pass the mixed material through an 80-mesh sieve.

[0084] Step 3: Add 456 g of anhydrous sodium sulfate and the mixture 1 into a hopper mixer with a 2 L pot body, mixing speed: 15 rpm, mixing time: 10 min.

[0085] Step 4: Pass through an 80-mesh sieve.

[0086] Step 5: Add 800 g of polyethylene glycol 4000 and the mixture 2 into a three-dimensional mixer: in a 15 L pot body, mixing speed: no speed, mixing time: 10 min.

[0087] Step 6: Add 1500 g of polyethylene glycol 4000 and the mixture 3 into a three-dimensional mixer: in a 15 L pot body, mixing speed: no speed, mixing time: 15 min.

[0088] Step 7: Add 2840 g of polyethylene glycol 4000 and the mixture 4 into a three-dimensional mixer: in a 15 L pot body, mixing speed: no speed, mixing time: 15 min to obtain a sample.

[0089] Take 12 samples of the product prepared in Control Group 3, numbered 1f - 12f respectively, and the test data are as follows:

[0090]

[0091]

[0092] Control Group 4

[0093] Pretreatment: Sodium chloride, potassium chloride, sodium bicarbonate, and anhydrous sodium sulfate were respectively crushed and sieved through a 150-mesh sieve. The particle size D(90) of sodium chloride in the material: 80μm - 90μm, the particle size D(90) of potassium chloride: 80μm - 90μm, the particle size D(90) of sodium bicarbonate: 80μm - 90μm, and the particle size D(90) of anhydrous sodium sulfate: 80μm - 90μm.

[0094] Step 1: Take 60g of potassium chloride, 116.85g of sodium chloride, and 134.47g of sodium bicarbonate and place them in the 2L pot body of a hopper mixer. Mixing speed: 15rpm, mixing time: 10min.

[0095] Step 2: The mixed material was sieved through a 100-mesh sieve.

[0096] Step 3: Add 456g of anhydrous sodium sulfate and Mixture 1 to the 2L pot body of a hopper mixer. Mixing speed: 15rpm, mixing time: 10min.

[0097] Step 4: Sieved through a 100-mesh sieve.

[0098] Step 5: Add 800g of polyethylene glycol 4000 and Mixture 2 to a three-dimensional mixer: in the 15L pot body. Mixing speed: no speed, mixing time: 10min.

[0099] Step 6: Add 1500g of polyethylene glycol 4000 and Mixture 3 to a three-dimensional mixer: in the 15L pot body. Mixing speed: no speed, mixing time: 15min.

[0100] Step 7: Add 2840g of polyethylene glycol 4000 and Mixture 4 to a three-dimensional mixer: in the 15L pot body. Mixing speed: no speed, mixing time: 15min to obtain the sample.

[0101] Take 12 samples of the product prepared from Control Group 4, numbered 1g - 12g respectively, and the test data are as follows

[0102]

[0103]

[0104] It can be seen from the experimental results that Control Group 1, Control Group 2, Control Group 3, Control Group 4 and Examples 1-3 adopted different mixing processes and different material particle size controls, and there were significant differences in the mixing results. The processes of Examples 1-3 optimized according to the results are the process content of the present invention. According to the detection of sodium bicarbonate, total chlorine content and potassium chloride in the prescription, it is found that when the inorganic salt particle size is controlled at 150 mesh and below, and the polyethylene glycol 4000 particle size is controlled at 60 mesh and below, the mixing uniformity result is the best.

[0105] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements on some of the technical features. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A preparation method of polyethylene glycol 4000 electrolyte powder, characterized in that, The steps are as follows: S1. Sodium chloride, potassium chloride, sodium bicarbonate, and anhydrous sodium sulfate are respectively crushed and sieved through a 150-mesh sieve; The particle size D90 of the material sodium chloride is 80 μm - 90 μm, the particle size D90 of potassium chloride is 80 μm - 90 μm, the particle size D90 of sodium bicarbonate is 80 μm - 90 μm, and the particle size D90 of anhydrous sodium sulfate is 80 μm - 90 μm; Polyethylene glycol 4000 is crushed and sieved through a 60-mesh sieve, and the particle size D90 is 220 μm - 230 μm; S2. Take 50 - 70 g of potassium chloride, 110 - 120 g of sodium chloride, and 130 - 140 g of sodium bicarbonate and place them in the 2L pot body of a hopper mixer. Mixing speed: 10 - 20 rpm, mixing time: 8 - 12 min; After mixing, the material is sieved through a 120-mesh sieve to obtain mixture 1; S3. Add 440 - 460 g of anhydrous sodium sulfate and mixture 1 to the 2L pot body of a hopper mixer. Mixing speed: 10 - 20 rpm, mixing time: 8 - 12 min; Then it is sieved through a 120-mesh sieve to obtain mixture 2; S4. Add 750 - 850 g of polyethylene glycol 4000 and mixture 2 to a three-dimensional mixer: in the 15L pot body, mixing time: 8 - 12 min, to obtain mixture 3; S5. Add 1450 - 1550 g of polyethylene glycol 4000 and mixture 3 to a three-dimensional mixer: in the 15L pot body, mixing time: 10 - 20 min, to obtain mixture 4; S6. Add 2800 - 3000 g of polyethylene glycol 4000 and mixture 4 to a three-dimensional mixer: in the 15L pot body, mixing time: 10 - 20 min, to obtain the target product.

2. The preparation method of polyethylene glycol 4000 electrolyte powder according to claim 1, characterized in that: In step S1, the particle size D90 of sodium chloride is 85 μm, the particle size D90 of potassium chloride is 85 μm, the particle size D90 of sodium bicarbonate is 85 μm, and the particle size D90 of anhydrous sodium sulfate is 85 μm; Polyethylene glycol 4000 is crushed and sieved through a 60-mesh sieve, and the particle size D90 is 85 μm.

3. A method for preparing polyethylene glycol 4000 electrolyte powder according to claim 1, characterized in that: In step S2, take 60 g of potassium chloride, 116.85 g of sodium chloride, and 134.47 g of sodium bicarbonate and place them in the 2L pot body of a hopper mixer. Mixing speed: 15 rpm, mixing time: 10 min.

4. A preparation method of polyethylene glycol 4000 electrolyte powder according to claim 1, characterized in that: In step S3, add 456 g of anhydrous sodium sulfate and mixture 1 to the 2L pot body of a hopper mixer. Mixing speed: 15 rpm, mixing time: 10 min.

5. A preparation method of polyethylene glycol 4000 electrolyte powder according to claim 1, characterized in that: In step S4, add 800 g of polyethylene glycol 4000 and mixture 2 to a three-dimensional mixer: in the 15L pot body, mixing time: 10 min.

6. A preparation method of polyethylene glycol 4000 electrolyte powder according to any one of claim 1, characterized in that: In step S5, add 1500 g of polyethylene glycol 4000 and mixture 3 to a three-dimensional mixer: in the 15L pot body, mixing time: 15 min.

7. A preparation method of polyethylene glycol 4000 electrolyte powder according to any one of claim 1, characterized in that: In step S6, add 2840 g of polyethylene glycol 4000 and mixture 4 to a three-dimensional mixer: in the 15L pot body, mixing time: 15 min.

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