Composition with effects of benefiting qi, nourishing blood and improving sleep based on zizyphaceae plants and preparation method of composition

Abstract

The invention relates to the technical field of food and medicine health-care products, in particular to a composition with functions of benefiting qi, nourishing blood and improving sleep based on zizyphaceae plants and a preparation method of the composition. The composition comprises medical and edible dual-purpose components such as a golden silk jujube extract, collagen peptide, radix angelicae powder, blood protein polypeptide, pomegranate concentrated powder, a spearmint extract and a saffron crocus extract, and the composition is prepared by taking the golden silk jujube extract as a core and cooperating with the collagen peptide, the pomegranate concentrated powder, the saffron crocus and the spearmint extract. And integrated health intervention of benefiting qi, nourishing blood, improving sleep and repairing skin is realized through the multi-target effect.

Description

Technical Field

[0001] The present invention relates to the technical field of food and drug health products, and particularly relates to a composition for supplementing qi and nourishing blood and improving sleep based on jujube plants and a preparation method thereof. Background Art

[0002] Qi and blood originate from the zang-fu organs and circulate in the meridians and blood vessels. Qi is the commander of blood, and blood is the mother of qi. The two coordinate with each other and function interdependently. In traditional Chinese medicine, qi and blood are one of the key factors in maintaining skin health. When the body is deficient in qi and blood, the skin will also suffer. Qi and blood can nourish the skin and keep it elastic and shiny. If qi and blood are insufficient, the skin will lose these characteristics and become dull, dry, and rough. In addition, insufficient qi and blood may also lead to problems such as pigmentation and age spots. Women with qi and blood deficiency often have a sallow complexion and may even show symptoms of dullness and long spots. Women with sufficient qi and blood often have healthy skin with a rosy glow and elasticity.

[0003] With the accelerating pace of life and great work pressure, mental tension, anxiety, and overuse of the brain will all cause disorders of the brain's nerve function, resulting in stasis of qi and blood stasis and insomnia. Lack of sleep leads to endocrine imbalance and blocked blood circulation, promoting the increase of cortisol, inhibiting collagen synthesis, damaging the skin barrier, inducing problems such as dullness, dryness, relaxation, and dark circles, and accelerating aging; endocrine disorders will affect the operation of qi and blood and skin metabolism and repair, resulting in insufficient skin nourishment, abnormal sebum secretion, and damaged barrier function, further accelerating aging. Long-term qi and blood deficiency will make the skin fall into a state of "exhausted nourishment", resulting in sallow and dull skin color, accelerated formation of fine lines and wrinkles, and haggard and aging appearance. After the barrier function declines, the skin is difficult to repair and may even develop chronic inflammation, accelerating skin aging.

[0004] CN118490783A discloses a traditional Chinese medicine formula for nourishing both qi and blood and improving sleep, which relates to the technical field of traditional Chinese medicine. The present invention includes Chinese yam, polygonatum sibiricum, wolfberry, longan, angelica dahurica, and maca. The weight components of each herb are: 20 grams of Chinese yam, 10 grams of polygonatum sibiricum, 10 grams of wolfberry, 5 grams of longan, 8 grams of angelica dahurica, and 5 grams of maca. By adding herbs such as Chinese yam, polygonatum sibiricum, wolfberry, and longan, the present invention can make up for the deficiencies of different organs, thereby achieving the effects of calming the nerves and enhancing intelligence. Moreover, the efficacy is stable, and it has the effects of nourishing blood, regulating menstruation, and enriching blood. It can regulate the qi and blood balance of the body and help improve sleep quality. CN109966375A discloses a health product for tonifying the kidney and calming the nerves, supplementing qi and nourishing blood, and improving sleep and its preparation method. The raw materials are as follows by weight: 100g of donkey-hide gelatin, 80g of American ginseng, 80g of longan pulp, 50g of wolfberry, 50g of angelica sinensis, 50g of red dates, and 2.5g of ferrous lactate. In this formula, donkey-hide gelatin tonifies the blood vessels and astringes the liver to nourish yin; American ginseng is a precious traditional Chinese medicine for tonifying qi and yin, enhancing the immune function. Longan pulp has the effect of strengthening the spleen and nourishing blood. Wolfberry nourishes the liver and kidney, benefits essence and improves eyesight; Angelica sinensis has the effects of promoting blood circulation and nourishing blood, enhancing the immune function. Red dates invigorate the spleen and stomach, replenish qi and promote fluid production. Ferrous lactate is to supplement trace elements and enhance the immune function. The solutions reported in the above patent documents all have a bitter taste that affects the taste, and at the same time, the effects need to be improved.

[0005] Therefore, the present application provides a composition for tonifying qi and nourishing blood and improving sleep based on plants of the Ziziphus family and its preparation method. Summary of the Invention

[0006] In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is to provide a composition for tonifying qi and nourishing blood and improving sleep based on plants of the Ziziphus family and its preparation method. It uses extracts of small Chinese jujubes, collagen peptides, angelica dahurica powder, blood protein polypeptides, red pomegranate concentrated powder, mentha spicata extracts, and saffron extracts. This composition does not contain Western medicines and are all substances that can be used both as medicine and food. These substances interact with each other to improve health problems through multiple channels. In the present invention, various active ingredients such as saffron and mentha spicata extracts work together synergistically to improve sleep quality, deeply repair and nourish the skin while sleeping, and restore qi and blood; red pomegranate concentrated powder is used to bidirectionally regulate hormone levels and restore the stability of the body's own hormone levels. The extracts of small Chinese jujubes and blood protein polypeptides are used to tonify qi and nourish blood doubly, and fundamentally improve the qi and blood problems.

[0007] To achieve the above object, the present invention provides a composition for tonifying qi and nourishing blood and improving sleep based on plants of the Ziziphus family, which is characterized in that it includes the following raw materials: extracts of small Chinese jujubes, collagen peptides, angelica dahurica powder, blood protein polypeptides, red pomegranate concentrated powder, mentha spicata extracts, and saffron extracts.

[0008] Furthermore, a composition for tonifying qi and nourishing blood and improving sleep based on plants of the Ziziphus family includes the following raw materials:

[0009] 70 - 90 parts by weight of small golden jujube extract, 5 - 15 parts by weight of collagen peptide, 1 - 5 parts by weight of angelica dahurica powder, 3 - 10 parts by weight of blood protein polypeptide, 2 - 8 parts by weight of concentrated pomegranate powder, 1 - 5 parts by weight of spearmint extract, 1 - 5 parts by weight of saffron extract.

[0010] The small golden jujube extract has the functions of enhancing hematopoietic function, improving blood supply capacity, promoting the regeneration of bone marrow stem cells, enhancing myocardial blood supply, and increasing blood volume from the source; improving immunity, restoring the health of the body, enhancing the body's immune response, and creating a good environment for the generation and flow of qi and blood; nourishing qi and blood, red dates invigorate the spleen and stomach, replenish qi and promote the production of body fluid, regulate nutrient qi and defensive qi, and detoxify drugs; treating qi, blood and body fluid deficiency, disharmony between nutrient qi and defensive qi, palpitation and anxiety; advanced CO2 low-temperature supercritical extraction process, free of solvents and process residues, ensuring 100% natural, avoiding by-products that may be introduced during the long-term high-temperature extraction process, and highly extracting bioactive substances (cAMP). The small golden jujube extract contains adenosine cyclic phosphate, and the content of cyclic adenosine monophosphate is 15 mg / 100 g of extract; cyclic adenosine monophosphate is an important substance in human cells that participates in regulating material metabolism and biological functions, and plays a very important role in repairing brain cells, activating brain cells, and regulating brain cell functions, converting short-term memory into long-term memory, relieving brain cell fatigue, and delaying brain cell aging.

[0011] Collagen is the main component of the dermis of the skin, accounting for up to 75%, like a "skin scaffold", maintaining skin elasticity, firmness and water content. Supplementing collagen helps to increase skin thickness, improve blood microcirculation, and make the skin rosy and bright. Collagen synergizes with iron and vitamin C to enhance hematopoietic function. Iron is a key element in hematopoiesis, while collagen peptide can promote the absorption and utilization of iron, increase red blood cell production, and improve anemia. Vitamin C promotes collagen synthesis and at the same time enhances blood circulation, making the skin more firm, elastic and shiny.

[0012] Phytochemical active substances derived from pomegranate, such as ESTROBAL@, can act similarly to selective estrogen receptor modulators (SERMs). When the estrogen level in the human body is low, ESTROBAL pomegranate concentrate occupies estrogen receptors, exerts a weak estrogenic effect, shows the effect of increasing estrogen levels, and treats hypoestrogenism; when the estrogen level in the human body is high, ESTROBAL pomegranate concentrate and endogenous estrogen occupy receptor positions in a "competitive" manner, preventing the binding of estrogen in the body to receptors, thus effectively weakening the response of target cells to estrogen, and playing an anti-estrogenic role, showing the effect of reducing hormone levels; ESTROBAL@ pomegranate concentrate restores the balance of estrogen in the body through bidirectional regulation. Pomegranate extracts contain plant active substances such as pomegranate flavonoids, which can supplement estrogen, activate ovarian cells, and prevent premature ovarian failure.

[0013] The extract of Mentha spicata contains various polyphenols such as salvianolic acid, lithospermic acid, and rosmarinic acid, which can inhibit cholinesterase activity, ensure the transmission of memory information, and enhance memory. Salvianolic acid and rosmarinic acid in the extract of Mentha spicata can act on the levels of neurotransmitters in the brain that affect mood, relieve bad emotions, help fall asleep quickly, and improve sleep quality. The various polyphenols in the extract of Mentha spicata eliminate the inflammatory state of the brain, relieve brain fatigue, and enhance the active state of the brain. The natural polyphenol antioxidants in Mentha spicata stimulate the regeneration of neurons. The more neurons there are, the faster the signal transmission.

[0014] There are various natural activities in saffron, including crocetin, crocin, saffranal, picrocrocin, and other derivatives. Under the action of vitamin B group, they can synthesize 5-HTP by themselves, which can play a role in stabilizing emotions and improving anxiety. Saffron is rich in tryptophan, which can synthesize melatonin in the body by itself, and improve sleep quality by regulating the circadian rhythm of the human body. Melatonin, as a kind of amine hormone secreted by the pineal gland in the brain, itself does not have the effect of inhibiting central excitement or sedation and hypnosis. It mainly improves sleep quality by regulating the circadian rhythm of the human body.

[0015] Angelica dahurica has a pungent taste and a warm nature. It belongs to the stomach, large intestine, and lung meridians, and has the effects of relieving exterior syndrome and dispelling cold, expelling wind and relieving pain, promoting nasal passage, drying dampness and arresting leukorrhea, and detumescence and discharging pus.

[0016] Hemoglobin polypeptide is absorbed in the form of small peptides, and its absorption rate is about 5-10 times higher than that of traditional iron agents. It has the effects of improving qi and blood deficiency and anti-aging at the root.

[0017] In the present invention, various functional components such as saffron and spearmint extracts synergistically assist to improve sleep quality, deeply repair and nourish the skin while sleeping, and restore qi and blood; red pomegranate concentrated powder is used to bidirectionally regulate hormone levels and restore the stability of the body's own hormone levels. Jujube extract and hemoglobin polypeptide are used to supplement qi and nourish blood doubly, and fundamentally improve the problem of qi and blood deficiency.

[0018] In the present invention, jujube extract, collagen peptide, angelica dahurica powder, hemoglobin polypeptide, red pomegranate concentrated powder, spearmint extract, and saffron extract are mixed. The composition does not contain western medicine and all are substances that can be used both as medicine and food. In terms of supplementing qi and nourishing blood, each component synergistically promotes hematopoietic function and nutrient absorption, improves qi and blood deficiency, regulates endocrine, alleviates health problems caused by hormone imbalance, improves nerve function, significantly improves sleep quality and prolongs deep sleep time by stabilizing the balance of neurotransmitters and reducing brain fatigue. The antioxidant components synergistically delay cell aging, enhance skin elasticity and barrier function; at the same time, activate the activity of immune cells and build multiple defense mechanisms, and finally effectively achieve comprehensive improvement capabilities in multiple aspects such as supplementing qi and nourishing blood, regulating endocrine, improving nerve function, delaying aging, and enhancing immunity.

[0019] The present invention also discloses a preparation method of a composition with the functions of supplementing qi and nourishing blood and improving sleep based on jujube plants, comprising the following steps: mixing jujube extract, collagen peptide, angelica dahurica powder, hemoglobin polypeptide, red pomegranate concentrated powder, spearmint extract, and saffron extract evenly, and using steam conditioning and drying to obtain the composition.

[0020] Small molecule polypeptides are easily affected by many factors, especially oxidation, which will reduce their biological activity, and are easily degraded by proteases in the gastrointestinal tract. However, in the food and health product industries, spray drying is the most widely used. Drying small molecule polypeptides by methods such as spray drying is likely to cause problems such as oxidation and easy degradation of small molecule polypeptides. Traditional Chinese medicine extracts contain a large amount of active ingredients, but the active ingredients are easily affected by the external environment, and at the same time, their bitter taste affects the taste. On this basis, the present invention introduces modified chitosan, peach gum modified egg white protein, effectively improves the problems of easy oxidation and easy degradation of polypeptides, and the active ingredients in the extract are easily affected by the external environment, and improves the taste, thereby improving sleep quality, supplementing qi and blood, and enhancing immunity.

[0021] Tremella polysaccharide belongs to polysaccharide substances, contains rich nutrients, has good immunomodulatory effects, and also has good emulsifying and stabilizing properties; egg white protein contains amino acid composition and bioactive peptide components. In the present invention, treating egg white protein with tremella polysaccharide can not only effectively improve immunity and provide nutrition, but also has good emulsifying effects. It interacts with modified chitosan to improve problems such as easy degradation and oxidation of active ingredients, and at the same time improves the taste; in the present invention, linoleic acid and citric acid are used to treat chitosan, making chitosan amphiphilic, which can self-assemble through intermolecular or intramolecular interactions and interact with tremella-modified egg white protein, effectively improving sleep, supplementing qi and blood, while enhancing immunity and supplementing nutrients.

[0022] Further preferably, a composition based on Ziziphus plants for invigorating qi and nourishing blood and improving sleep comprises the following raw materials:

[0023] 70-90 parts by weight of small golden jujube extract, 5-15 parts by weight of collagen peptide, 1-5 parts by weight of angelica dahurica powder, 3-10 parts by weight of blood protein polypeptide, 2-8 parts by weight of red pomegranate concentrated powder, 1-5 parts by weight of spearmint extract, 1-5 parts by weight of saffron extract, 10-25 parts by weight of modified chitosan, 5-15 parts by weight of tremella-modified egg white protein.

[0024] The preparation method of the modified chitosan is as follows: adding chitosan into 50wt% acetic acid aqueous solution and mixing evenly to obtain a chitosan solution with a concentration of 1-2wt%; adding linoleic acid into absolute ethanol and mixing evenly to obtain a linoleic acid solution with a concentration of 0.1-0.5wt%; adding citric acid into water and mixing evenly to obtain a citric acid solution with a concentration of 0.05-0.2wt%; adding 0.3-0.6 parts by weight of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) and 0.3-0.6 parts by weight of N-hydroxysuccinimide (NHS) into 30-50 parts by weight of 50wt% ethanol aqueous solution and mixing evenly to obtain a mixed solution; then adding the mixed solution, linoleic acid solution, and citric acid solution into the chitosan solution and mixing evenly, stirring and reacting at room temperature for 24h. After the reaction, dialyze with water for two days, and freeze-dry the dialysate to obtain modified chitosan;

[0025] The volume ratio of the mixed solution, linoleic acid solution, citric acid solution, and chitosan solution is 30-60mL: 30-60mL: 30-60mL: 30-60mL;

[0026] The preparation method of the tremella-modified egg white protein is as follows: adding tremella into water and mixing evenly, heating to 60-70°C and soaking for 1-3h, then beating into a pulp, ultrasonically treating the pulp, and keeping it at 50-60°C to obtain a tremella solution; mixing the tremella solution and egg white protein evenly and heating to 70-80°C for 6-10h to obtain tremella-modified egg white protein;

[0027] Among them, the mass ratio of peach gum to water is 1:8 - 10; the mass ratio of the peach gum solution to egg white protein is 4:0.5 - 2;

[0028] Among them, the conditions for ultrasonic treatment are treatment for 20 - 40 min under the conditions of ultrasonic power of 200 - 400 W and temperature of 45 - 65 °C.

[0029] The present invention also discloses a preparation method of a composition based on Ziziphus jujuba plants with the functions of invigorating qi and nourishing blood and improving sleep.

[0030] A preparation method of a composition based on Ziziphus jujuba plants with the functions of invigorating qi and nourishing blood and improving sleep, comprising the following steps:

[0031] Mix the extract of small Chinese date, collagen peptide, angelica dahurica powder, blood protein polypeptide, red pomegranate concentrated powder, mentha spicata extract, and saffron extract evenly, and adopt steam conditioning and drying to obtain the active ingredient;

[0032] Add modified chitosan into water and mix evenly, add an emulsifier and mix evenly, then add the active ingredient and mix evenly, add peach gum - modified egg white protein and 1 - 2 wt% calcium chloride solution, cure at room temperature for 4 - 6 h, filter and dry to obtain the composition.

[0033] The composition provided by the present invention can be directly taken orally as medicine or prepared into the required preparation according to the conventional process by adding pharmaceutically acceptable excipients. For example, it can be made into common solid - dosage - form oral drugs such as tablets (dispersible tablets, effervescent tablets, orally disintegrating tablets, lozenges, chewable tablets), capsules (hard capsules, soft capsules), granules, pills (dripping pills), powders, etc., or can also be made into liquid - dosage - form oral drugs such as syrup, oral liquid, etc.; therefore, in addition to the active ingredients, the composition can also contain pharmaceutically acceptable excipients.

[0034] Advantages of the present invention:

[0035] Compared with the prior art, in the present invention, the extract of small Chinese date, collagen peptide, angelica dahurica powder, blood protein polypeptide, red pomegranate concentrated powder, mentha spicata extract, and saffron extract are mixed. This composition does not contain western medicine and all are substances that can be used both as medicine and food. These substances interact with each other to improve health problems through multiple pathways. In the present invention, multiple efficacy components such as saffron and mentha spicata extract synergistically help to improve the sleep quality, deeply repair and nourish the skin while sleeping, and restore qi and blood; the red pomegranate concentrated powder is used to bidirectionally regulate the hormone level and restore the stability of the body's own hormone level. The extract of small Chinese date and blood protein polypeptide are used to double - invigorate qi and nourish blood to fundamentally improve the qi and blood problems. Specific embodiments

[0036] In the ranges disclosed in the present invention, the endpoints and any values are not limited to the exact ranges or values. These ranges or values should be understood to include values close to these ranges or values. For numerical ranges, between the endpoint values of each range, between the endpoint values of each range and individual point values, and between individual point values, they can be combined with each other to obtain one or more new numerical ranges, and these numerical ranges should be regarded as specifically disclosed in the present invention.

[0037] Introduction to some raw materials used in the embodiments of the present invention:

[0038] The preparation method of the Ziziphus jujuba Mill. cv. Jinsixiaozao extract used in the embodiments was prepared with reference to Example 1 in Patent CN103623080B.

[0039] The pomegranate concentrate powder used in the embodiments is Pomegranate concentrate powder, which is a commercially available product purchased from Miaopinyuan.

[0040] The preparation method of the Mentha spicata L. extract used in the embodiments is as follows: Dry and crush Mentha spicata L. and pass it through a 80-mesh sieve to obtain Mentha spicata L. powder; Add Mentha spicata L. powder to 50 wt% ethanol aqueous solution according to the material-liquid ratio of 1 g: 40 mL, mix evenly, extract at a power of 100 W and a temperature of 60 °C for 60 min, extract 3 times, centrifuge to obtain the filtrate and filter residue; Add the filter residue to 75 wt% ethanol aqueous solution according to the material-liquid ratio of 1 g: 40 mL, mix evenly, extract at a power of 200 W and a temperature of 70 °C for 60 min, extract 3 times, centrifuge to obtain the filtrate, combine all the filtrates, concentrate and dry to obtain Mentha spicata L. extract.

[0041] The preparation method of the Crocus sativus L. extract used in the embodiments is as follows: Dry and crush Crocus sativus L. and pass it through a 80-mesh sieve to obtain Crocus sativus L. powder; Add Crocus sativus L. powder to water and mix evenly, add a composite enzyme (a mixture of trypsin (250000 U / g) and alkaline protease (200000 U / g) in a mass ratio of 1:1), heat to 38 °C for enzymatic hydrolysis for 3 h, inactivate the enzyme after enzymatic hydrolysis, filter to obtain the filtrate and filter residue, where the material-liquid ratio of Crocus sativus L. powder to water is 1 g: 40 mL, and the addition amount of the composite enzyme is 5 wt% of Crocus sativus L. powder; Add the filter residue to 75 wt% ethanol aqueous solution according to the material-liquid ratio of 1 g: 40 mL, mix evenly, extract at a power of 200 W and a temperature of 60 °C for 60 min, extract 3 times, centrifuge to obtain the filtrate, combine all the filtrates, concentrate and dry to obtain Crocus sativus L. extract.

[0042] The preparation method of the Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav. powder used in the embodiments is to dry and crush Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav. and pass it through a 100-mesh sieve to obtain Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav. powder.

[0043] All other raw materials not mentioned are common raw materials. The above content is only for helping to illustrate the present invention and should not be construed as a strict limitation of the present invention. Those skilled in the art can directly purchase from the market or prepare the same or similar raw materials by themselves.

[0044] Next, specific embodiments of the present invention will be combined to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0045] Example 1

[0046] A preparation method of a composition based on jujube plants with the functions of invigorating qi and nourishing blood and improving sleep includes the following steps:

[0047] Mix 82 parts by weight of small golden jujube extract, 12 parts by weight of collagen peptide, 4 parts by weight of angelica dahurica powder, 8 parts by weight of hemoglobin polypeptide, 6 parts by weight of pomegranate concentrate powder, 5 parts by weight of spearmint extract, and 3 parts by weight of saffron extract evenly, and use steam conditioning and drying to obtain the composition.

[0048] Example 2

[0049] A preparation method of a composition based on jujube plants with the functions of invigorating qi and nourishing blood and improving sleep includes the following steps:

[0050] Mix 90 parts by weight of small golden jujube extract, 15 parts by weight of collagen peptide, 1 part by weight of angelica dahurica powder, 10 parts by weight of hemoglobin polypeptide, 3 parts by weight of pomegranate concentrate powder, 1 part by weight of spearmint extract, and 2 parts by weight of saffron extract evenly, and use steam conditioning and drying to obtain the composition.

[0051] Example 3

[0052] A preparation method of a composition based on jujube plants with the functions of invigorating qi and nourishing blood and improving sleep includes the following steps:

[0053] Mix 70 parts by weight of small golden jujube extract, 5 parts by weight of collagen peptide, 5 parts by weight of angelica dahurica powder, 3 parts by weight of hemoglobin polypeptide, 2 parts by weight of pomegranate concentrate powder, 3 parts by weight of spearmint extract, and 1 part by weight of saffron extract evenly, and use steam conditioning and drying to obtain the composition.

[0054] Example 4

[0055] A preparation method of a composition based on jujube plants with the functions of invigorating qi and nourishing blood and improving sleep includes the following steps:

[0056] Mix 82 parts by weight of jujube extract, 12 parts by weight of collagen peptide, 4 parts by weight of angelica dahurica powder, 8 parts by weight of hemoglobin polypeptide, 6 parts by weight of pomegranate concentrate powder, 5 parts by weight of spearmint extract, and 3 parts by weight of saffron extract evenly, and use steam conditioning and drying to obtain the active ingredient;

[0057] Add 12 parts by weight of modified chitosan to 100 parts by weight of water and mix evenly, add 4 parts by weight of Tween 80 and mix evenly, then add 10 parts by weight of the active ingredient and mix evenly. Add 7 parts by weight of peach gum-modified egg white protein and 10 parts by weight of 2wt% calcium chloride solution, cure at room temperature for 4h, filter and dry to obtain the composition.

[0058] The preparation method of the modified chitosan is as follows: Add chitosan to 50wt% acetic acid aqueous solution and mix evenly to obtain a chitosan solution with a concentration of 1wt%; add linoleic acid to absolute ethanol and mix evenly to obtain a linoleic acid solution with a concentration of 0.3wt%; add citric acid to water and mix evenly to obtain a citric acid solution with a concentration of 0.15wt%; add 0.6 parts by weight of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 0.6 parts by weight of N-hydroxysuccinimide to 50 parts by weight of 50wt% ethanol aqueous solution and mix evenly to obtain a mixed solution; then add the mixed solution, linoleic acid solution, and citric acid solution to the chitosan solution and mix evenly, stir and react at room temperature for 24h. After the reaction, dialyze with water for two days (cut-off molecular weight 7000Da), and freeze-dry the dialysate to obtain the modified chitosan; the volume ratio of the mixed solution, linoleic acid solution, citric acid solution, and chitosan solution is 50mL:50mL:50mL:50mL;

[0059] The preparation method of the peach gum-modified egg white protein is as follows:

[0060] Add peach gum to water and mix evenly, heat to 70°C and soak for 2h, then beat into a pulp, treat the pulp under the conditions of ultrasonic power of 200W and temperature of 55°C for 40min, and keep warm at 55°C to obtain a peach gum solution; mix the peach gum solution and egg white protein evenly and heat to 80°C for 8h to obtain the peach gum-modified egg white protein; the mass ratio of peach gum to water is 1:10; the mass ratio of the peach gum solution to egg white protein is 4:2.

[0061] Example 5

[0062] A preparation method of a composition based on jujube plants with the functions of invigorating qi and nourishing blood and improving sleep, comprising the following steps:

[0063] Mix 82 parts by weight of extract of Ziziphus jujuba Mill. cv. Jinsixiaozao, 12 parts by weight of collagen peptide, 4 parts by weight of Angelica dahurica powder, 8 parts by weight of hemoglobin polypeptide, 6 parts by weight of concentrated pomegranate powder, 5 parts by weight of Mentha spicata extract, and 3 parts by weight of Crocus sativus extract evenly, and obtain the active ingredient by steam conditioning and drying;

[0064] Add 12 parts by weight of chitosan to 100 parts by weight of water and mix evenly. Add 4 parts by weight of Tween 80 and mix evenly, then add 10 parts by weight of the active ingredient and mix evenly. Add 7 parts by weight of peach gum-modified egg white protein and 10 parts by weight of 2 wt% calcium chloride solution, cure at room temperature for 4 h, filter and dry to obtain the composition.

[0065] The preparation method of the peach gum-modified egg white protein is as follows:

[0066] Add peach gum to water and mix evenly. Heat to 70 °C and soak for 2 h, then beat into a pulp. Treat the pulp under the conditions of ultrasonic power of 200 W and temperature of 55 °C for 40 min, and keep warm at 55 °C to obtain a peach gum solution; Mix the peach gum solution and egg white protein evenly and heat to 80 °C for 8 h to obtain the peach gum-modified egg white protein; The mass ratio of peach gum to water is 1:10; The mass ratio of the peach gum solution to egg white protein is 4:2.

[0067] Example 6

[0068] A preparation method of a composition based on jujube plants with the functions of invigorating qi and nourishing blood and improving sleep, comprising the following steps:

[0069] Mix 82 parts by weight of extract of Ziziphus jujuba Mill. cv. Jinsixiaozao, 12 parts by weight of collagen peptide, 4 parts by weight of Angelica dahurica powder, 8 parts by weight of hemoglobin polypeptide, 6 parts by weight of concentrated pomegranate powder, 5 parts by weight of Mentha spicata extract, and 3 parts by weight of Crocus sativus extract evenly, and obtain the active ingredient by steam conditioning and drying;

[0070] Add 12 parts by weight of modified chitosan to 100 parts by weight of water and mix evenly. Add 4 parts by weight of Tween 80 and mix evenly, then add 10 parts by weight of the active ingredient and mix evenly. Add 7 parts by weight of egg white protein and 10 parts by weight of 2 wt% calcium chloride solution, cure at room temperature for 4 h, filter and dry to obtain the composition.

[0071] The preparation method of the modified chitosan is as follows: Chitosan is added to an aqueous acetic acid solution with a concentration of 50 wt% and mixed evenly to obtain a chitosan solution with a concentration of 1 wt%. Linoleic acid is added to absolute ethanol and mixed evenly to obtain a linoleic acid solution with a concentration of 0.3 wt%. Citric acid is added to water and mixed evenly to obtain a citric acid solution with a concentration of 0.15 wt%. 0.6 parts by weight of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 0.6 parts by weight of N-hydroxysuccinimide are added to 50 parts by weight of an aqueous ethanol solution with a concentration of 50 wt% and mixed evenly to obtain a mixed solution. Then, the mixed solution, the linoleic acid solution, and the citric acid solution are added to the chitosan solution and mixed evenly, and the mixture is stirred and reacted at room temperature for 24 h. After the reaction is completed, it is dialyzed with water for two days (the cut-off molecular weight is 7000 Da), and the dialysate is freeze-dried to obtain the modified chitosan. The volume ratio of the mixed solution, the linoleic acid solution, the citric acid solution, and the chitosan solution is 50 mL:50 mL:50 mL:50 mL.

[0072] Example 7

[0073] A preparation method of a composition based on Ziziphus jujuba plants with the functions of invigorating qi and nourishing blood and improving sleep includes the following steps:

[0074] 82 parts by weight of extracts of small Chinese jujubes, 12 parts by weight of collagen peptides, 4 parts by weight of angelica dahurica powder, 8 parts by weight of blood protein polypeptides, 6 parts by weight of red pomegranate concentrated powder, 5 parts by weight of spearmint extracts, and 3 parts by weight of saffron extracts are mixed evenly, and are subjected to steam conditioning and drying to obtain active ingredients;

[0075] 12 parts by weight of chitosan is added to 100 parts by weight of water and mixed evenly, 4 parts by weight of Tween 80 is added and mixed evenly, then 10 parts by weight of the active ingredients are added and mixed evenly, 3.5 parts by weight of egg white protein, 3.5 parts by weight of peach gum, and 10 parts by weight of a 2 wt% calcium chloride solution are added, and the mixture is cured at room temperature for 4 h, and then filtered and dried to obtain the composition.

[0076] Test Example 1

[0077] Seventy experimental mice (body weight 20±2 g, healthy male, clean grade) were selected and kept in a laboratory at a temperature of 22°C - 25°C and a relative humidity of 60% - 80%. The mice had free access to food and water. After 5 days of adaptive feeding, the experiment began. The experimental mice were randomly divided into 7 groups. Among them, on the 1st, 3rd, 5th, 7th, and 9th days from the start of modeling, 0.2 mL / 10 g of blood was drawn from the tail of each mouse (that is, for every 10 g body weight of the mouse, 0.2 mL of blood was drawn), and on the 2nd, 4th, 6th, and 8th days from the start of modeling, cyclophosphamide was intraperitoneally injected into each mouse at 60 mg / kg, 40 mg / kg, 40 mg / kg, and 40 mg / kg respectively. The mice were fasted for 12 h before receiving cyclophosphamide but were allowed to drink water; the blank control group did not have blood drawn from the tail. While the other groups were injected with cyclophosphamide, the blank control group was only intraperitoneally injected with the same volume of normal saline. During the modeling process, the mice in the blank control group were normally fed without fasting or water restriction. The blank control group and the model control group were each orally gavaged with normal saline (0.9 wt% normal saline), 0.3 mL / 10 g, for 10 consecutive days; the experimental groups were each orally gavaged with the composition (concentration 0.8 g / mL), 0.3 mL / 10 g, for 10 consecutive days. 2 h after the last administration, blood was taken from the tail of each mouse in each group. After anticoagulation and dilution, the content of red blood cells (RBC), white blood cells (WBC), and platelets (PLT) in peripheral blood was detected on a fully automatic blood cell counter.

[0078] Table 1 Experimental results of the composition in supplementing qi and nourishing blood

[0079] <![CDATA[RBC content / (10 12 / L)]]> <![CDATA[WBC content / (10 9 / L)]]> <![CDATA[PLT content / (10 9 / L)]]> Blank control group 8.7 9.52 67.25 Model control group 4.75 5.25 41.38 Example 1 5.49 6.17 46.04 Example 4 7.61 8.34 62.13 Example 5 6.88 7.21 52.46 Example 6 7.13 7.80 57.09 Example 7 6.25 6.83 50.71

[0080] As can be seen from Table 1, the composition prepared in the examples has a good effect of supplementing qi and nourishing blood. In the present invention, the composition is prepared by mixing extracts of small golden jujubes, collagen peptides, angelica dahurica powder, blood protein polypeptides, red pomegranate concentrated powder, mentha spicata extracts, and saffron extracts. This composition does not contain western medicine and all substances are both edible and medicinal. These substances interact with each other to improve health problems through multiple pathways. On this basis, the present invention introduces modified chitosan and peach gum-modified ovalbumin, effectively improving the problems of easy oxidation and degradation of polypeptides and the susceptibility of active ingredients in extracts to the external environment, which affects the active ingredients and improves the taste, thereby improving sleep quality, supplementing qi and blood, and enhancing immunity.

[0081] Tao gum belongs to polysaccharide substances, contains rich nutrients, has good immunomodulatory effects, and also has good emulsifying and stabilizing properties. In the present invention, treating egg white protein with tao gum can not only effectively improve immunity and provide nutrition, but also has good emulsifying effects. It interacts with modified chitosan to improve problems such as easy degradation and oxidation of active ingredients, and at the same time improves the taste. In the present invention, linoleic acid and citric acid are used to treat chitosan, making chitosan amphiphilic, which can self-assemble through intermolecular or intramolecular interactions and interact with tao gum-modified egg white protein, effectively improving sleep, supplementing qi and blood, while enhancing immunity and supplementing nutrients.

[0082] Test Example 2

[0083] Experimental mice weighing 22 - 25 g, clean grade, half male and half female, were randomly divided into 6 groups, with 10 mice in each group. The experimental environmental temperature was 20 - 25 °C and the relative humidity was 60 - 70%. The compositions prepared in the examples were intragastrically administered at a dose of 100 mg / kg. Another blank control group was set up and intragastrically administered with normal saline. The sleep latency (time when the righting reflex disappeared) and sleep duration (time from the disappearance of the righting reflex to recovery) of the mice in each group were observed and recorded.

[0084] Table 2 Experimental results of the composition improving sleep

[0085] Sleep latency time / min Sleep duration time / min Blank control group 6.40 12.06 Example 1 5.76 14.48 Example 4 3.51 21.57 Example 5 4.83 16.34 Example 6 4.12 18.22 Example 7 5.25 15.81

[0086] As can be seen from Table 2, the composition prepared in Example 4 significantly shortened the sleep latency and significantly prolonged the sleep duration. At the same time, the performance of Example 4 was significantly better than that of Examples 5 - 7. The possible reason is that in the present invention, treating egg white protein with tao gum can not only effectively improve immunity and provide nutrition, but also has good emulsifying effects. It interacts with modified chitosan to improve problems such as easy degradation and oxidation of active ingredients, and at the same time improves the taste. In the present invention, linoleic acid and citric acid are used to treat chitosan, making chitosan amphiphilic, which can self-assemble through intermolecular or intramolecular interactions and interact with tao gum-modified egg white protein, effectively improving sleep, supplementing qi and blood, while enhancing immunity and supplementing nutrients.

[0087] Test Example 3

[0088] Weigh the compositions prepared in the examples respectively (the recommended dosage for human consumption is 1 g / person / day), and set it at 0.5 g / kg·bw / d according to the recommended dosage for human consumption. Incorporate the test compositions into the basal diet and feed the rats continuously for 30 days. Measure the body weight and food intake once a week, calculate the weekly body weight and the total food utilization rate, observe for any signs of poisoning, variation, or death every day. At the end of the experiment, observe the blood biochemical and organ coefficient indicators and conduct pathological examinations. Test results: During the experiment, there were no abnormal changes in the organ weights and organ coefficients of the compositions prepared in each group of the examples. All blood and biochemical indicators were within the normal range. Therefore, no case changes related to the test compositions were observed, and no harmful effects were detected.

[0089] In the present invention, the extract of small Chinese date, collagen peptide, angelica dahurica powder, blood protein polypeptide, red pomegranate concentrate powder, mentha spicata extract, and saffron extract are mixed. This composition does not contain western medicine and all are substances that can be used both as medicine and food. These substances interact with each other, can greatly improve immunity, effectively improve sleep, and supplement qi and blood. In the present invention, multiple active ingredients such as saffron and mentha spicata extract work together synergistically to enhance the sleep quality, deeply repair and nourish the skin while sleeping, and restore qi and blood; the red pomegranate concentrate powder is used to bidirectionally regulate the hormone level and restore the stability of the body's own hormone level. The extract of small Chinese date and blood protein polypeptide are used to double supplement qi and nourish blood, and fundamentally improve the qi and blood problems.

[0090] The preferred specific embodiments of the present invention have been described in detail above. It should be understood that those of ordinary skill in the art can make many modifications and variations based on the concept of the present invention without creative efforts. Therefore, all technical solutions that can be obtained by those skilled in the art in the technical field of the present invention through logical analysis, reasoning, or limited experiments based on the concept of the present invention on the basis of the existing technology shall fall within the protection scope determined by the claims.

Claims

1. A composition based on jujube plants with the functions of replenishing qi and nourishing blood and improving sleep, characterized in that, It includes the following raw materials: small Chinese date extract, collagen peptide, angelica dahurica powder, hemoglobin polypeptide, red pomegranate concentrated powder, mentha spicata extract, and saffron extract.

2. The composition based on jujube plants with the functions of invigorating qi and nourishing blood and improving sleep according to claim 1, wherein It includes the following raw materials: 70 - 90 parts by weight of small Chinese date extract, 5 - 15 parts by weight of collagen peptide, 1 - 5 parts by weight of angelica dahurica powder, 3 - 10 parts by weight of hemoglobin polypeptide, 2 - 8 parts by weight of red pomegranate concentrated powder, 1 - 5 parts by weight of mentha spicata extract, and 1 - 5 parts by weight of saffron extract.

3. The composition based on jujube plants for supplementing qi and nourishing blood and improving sleep according to claim 1, wherein The small Chinese date extract is prepared by a CO2 low-temperature supercritical extraction process.

4. The composition based on jujube plants with the functions of invigorating qi and nourishing blood and improving sleep according to claim 1, wherein, The pomegranate concentrated powder is pomegranate concentrated powder 5. The composition based on jujube plants for supplementing qi and nourishing blood and improving sleep according to claim 1, characterized in that, The preparation method of the mentha spicata extract is as follows: Mentha spicata is treated with two ethanol aqueous solutions of different concentrations respectively.

6. The composition based on jujube plants with the functions of invigorating qi and nourishing blood and improving sleep according to claim 1, characterized in that, The preparation method of the saffron extract is as follows: Saffron is first treated with a compound enzyme and then treated with an ethanol aqueous solution.

7. The composition based on jujube plants with qi and blood tonifying and sleep improving functions as claimed in claim 1, characterized in that: The prepared composition can also be made into a preparation with or without adjuvants according to conventional processes.

8. The composition based on jujube plants for supplementing qi and nourishing blood and improving sleep according to claim 7, characterized in that: The preparation can be a tablet, granule, capsule, pill, or oral liquid preparation.

9. A preparation method of a composition based on jujube plants with the functions of invigorating qi and nourishing blood and improving sleep as described in any one of claims 1-8, characterized in that, It includes the following steps: Mix the small Chinese date extract, collagen peptide, angelica dahurica powder, hemoglobin polypeptide, red pomegranate concentrated powder, mentha spicata extract, and saffron extract evenly, and obtain the composition by steam conditioning and drying.