Leveling structure, pipetting equipment with leveling structure and leveling method

Abstract

The invention discloses a leveling structure, pipetting equipment with the leveling structure and a leveling method. The leveling structure comprises a base plate, a datum point assembly, at least two universal leveling assemblies and a connecting plate, one end of a leveled structure is vertically connected to the connecting plate; the connecting plate is connected to the base plate in an angle-adjustable mode through the datum point assembly and the universal leveling assembly. The base plate is connected with the rack; the datum point group and the at least two universal leveling assemblies are distributed at intervals; the leveling structure is applied to the pipetting equipment and is used for realizing leveling connection between the leveled structure and the rack. According to the leveling structure, the pipetting equipment with the leveling structure and the leveling method disclosed by the invention, the angle adjustment between the leveled structure and the substrate can be conveniently and accurately realized.

Description

Technical Field

[0001] The present invention belongs to the technical field of pipetting equipment, and particularly relates to a leveling structure, a pipetting equipment with a leveling structure, and a leveling method. Background Art

[0002] In existing pipetting equipment, the moving arm is directly fixed to the frame. However, due to machining errors and assembly errors, the moving arm cannot be precisely perpendicular to the frame, and may tilt in the up and down or left and right directions, thus affecting the normal use of the pipetting equipment. In addition, the following problems also exist:

[0003] 1. Insufficient stability during transportation: When the pipetting arm lacks a leveling function, if it is jolted or tilted during transportation, it may cause internal liquid residue or mechanical structure offset, affecting subsequent use. After repeated handling, the unleveled pipetting arm may cause wear or deformation of key components (such as guide rails, seals) due to uneven stress.

[0004] 2. Poor adaptability in exhibitions or demonstrations: When the exhibition booth floor is uneven or the temporary placement environment is unstable, the liquid level control of the pipetting arm may be inaccurate, resulting in demonstration failures (such as liquid dripping, inconsistent liquid suction volume). It cannot quickly adapt to experimental tables or display racks at different heights, affecting the operation convenience.

[0005] 3. Poor accuracy: When the pipetting arm is not leveled, the pipette tip may not be in perpendicular contact with the liquid surface, resulting in: inaccurate liquid suction volume (such as partial air mixing). Increased residual volume during liquid discharge (especially for viscous liquids). For high-precision experiments (such as PCR, cell sorting), a small angular deviation may lead to poor repeatability.

[0006] 4. Decreased long-term stability: The mechanical structure may cause: increased wear of the guide rail due to long-term uneven stress, affecting the Z-axis movement accuracy. Summary of the Invention

[0007] Aiming at the above deficiencies in the prior art, the present invention aims to provide a leveling structure, a pipetting equipment with a leveling structure, and a leveling method, which can conveniently and precisely realize the angle adjustment between the structure to be leveled and the substrate.

[0008] To achieve the above object, the present invention provides a leveling structure, including a substrate, a reference point assembly, at least two universal leveling assemblies, and a connecting plate; one end of a structure to be leveled is vertically connected to the connecting plate; the connecting plate is angle-adjustably connected to the substrate through the reference point assembly and the universal leveling assemblies; the substrate is connected to the frame; the reference point assembly and at least two of the universal leveling assemblies are distributed at intervals; the leveling structure is applied to a pipetting equipment to realize the leveling connection between the structure to be leveled and the frame.

[0009] As an implementation manner, the universal leveling assembly includes a customized stud, a third spherical washer, and a first bolt; an external thread is formed on the outer wall of the customized stud, a first through hole is formed along the axial direction, and an arc surface matching with the third spherical washer is formed at the top end of the customized stud; at least two stud mounting grooves are formed on one side of the substrate adjacent to the connecting plate, and internal threads matching with the external thread are formed on the inner walls of the stud mounting grooves; the customized stud is screwed into the stud mounting groove through the external thread and the internal thread; the third spherical washer is disposed between the top end of the customized stud and the connecting plate; at least two first connection holes are formed on the connecting plate; the first bolt sequentially passes through the first connection hole, the third spherical washer, and the first through hole and then is screwed to the substrate.

[0010] As an implementation manner, the reference point assembly includes a second spherical washer group and a second bolt; the second spherical washer group includes a first spherical washer and a second spherical washer that cooperate with each other; the first spherical washer is fixed on one side of the substrate adjacent to the connecting plate; the second spherical washer cooperates with the first spherical washer and is disposed between the first spherical washer and the connecting plate; a second connection hole is formed on the connecting plate; the second bolt sequentially passes through the second connection hole, the second spherical washer, and the first spherical washer and then is screwed to a second screw hole formed on the substrate or passes through a third through hole formed on the substrate and then is screwed to a second nut.

[0011] As an implementation manner, at least two first accommodation grooves corresponding to the positions of the customized studs are formed on one side of the connecting plate adjacent to the substrate; the third spherical washer and a part of the customized studs are accommodated in the first accommodation grooves.

[0012] As an implementation manner, a first screw hole is formed on the bottom surface of the stud mounting groove of the substrate; the first bolt sequentially passes through the first connection hole, the third spherical washer, and the first through hole and then is screwed to the first screw hole; or a second through hole is formed on the bottom surface of the stud mounting groove of the substrate; the first bolt sequentially passes through the first connection hole, the third spherical washer, the first through hole, and the second through hole and then is screwed to a first nut.

[0013] As an implementation manner, a wrench groove is formed at the top end of the customized stud, and the wrench groove communicates with the first through hole.

[0014] As an implementation manner, the universal leveling assembly further includes a first spherical washer group; the first spherical washer group is disposed between the side of the connecting plate away from the substrate and the end of the first bolt.

[0015] As an implementation manner, a second receiving groove corresponding to the position of the first spherical washer is formed on one side of the connecting plate adjacent to the substrate; the second spherical washer is wholly or partly received in the second receiving groove.

[0016] As an implementation manner, the reference point assembly further includes a third spherical washer group; the third spherical washer group is disposed between one side of the connecting plate away from the substrate and the end of the second bolt.

[0017] A pipetting device with a leveling structure according to the present invention includes the leveling structure, the frame and the structure to be leveled according to the present invention; the substrate is fixed on the frame; the structure to be leveled is connected to the connecting plate; the structure to be leveled includes a pipetting arm.

[0018] A leveling method based on the leveling structure according to the present invention includes the steps of:

[0019] S1: Start leveling the leveling structure in a state to be leveled, and the leveling structure in the state to be leveled does not install the second bolt, the third spherical washer group, the first bolt and the first spherical washer group;

[0020] S2: Move the connecting plate close to the substrate until the connecting plate together with the second spherical washer completely contacts the first spherical washer, and use a tool or an angle measuring tool to adjust the connecting plate to the position state finally required to be adjusted to;

[0021] S3: Install the second bolt and the third spherical washer group, and lock the reference point assembly;

[0022] S4: Adjust a universal leveling component. Use a wrench to pass through the corresponding first connection hole of the universal leveling component and a third spherical washer, and drive the customized stud to rotate through the wrench to adjust the height of the customized stud protruding from the substrate until the arc surface at the top of the customized stud completely contacts the arc surface of the third spherical washer;

[0023] S5: Assemble the first spherical washer group and the first bolt of the current universal leveling component; the first spherical washer group is disposed between one side of the connecting plate away from the substrate and the end of the first bolt; lock the first bolt;

[0024] S6: Repeat steps S4 and S5 to adjust the remaining universal leveling components in turn until all the universal leveling components are adjusted.

[0025] Since the present invention adopts the above technical solutions, the technical beneficial effects include:

[0026] By adopting the reference point assembly and at least two universal leveling assemblies, the angle adjustment between the connecting plate and the base plate is realized; the customized stud member is screwed into the stud installation groove through the external thread and the internal thread, and the height of the customized stud member protruding from the base plate can be adjusted by rotating the customized stud member, and the angle of the connecting plate in the plane where the reference point assembly is located can be adjusted by cooperating with the reference point assembly. The top of the customized stud member forms an arc surface that cooperates with the third spherical washer to realize the universal adjustment of the angle of the connecting plate. The adoption of the first receiving groove makes the structure between the connecting plate and the base plate more compact and improves the integration of the structure. The first screw hole is used for the screw connection between the first bolt and the base plate, which saves the connection space of the nut compared with the nut connection. The adoption of the wrench groove can conveniently use a wrench to rotate the customized stud member and adjust the height of the customized stud member. The first spherical washer group is used to compensate for the angle deviation between the connecting plate and the first bolt. The second spherical washer group adopts the universal leveling assembly to cooperate with each other, thereby realizing the universal adjustment of the angle of the connecting plate. The adoption of the second receiving groove makes the structure between the connecting plate and the base plate more compact and improves the integration of the structure. The third spherical washer set is used to compensate for the angular deviation between the connecting plate and the second bolt.

[0027] In addition, the liquid transfer device using the leveling structure of the present application also has the following beneficial effects:

[0028] 1. Strong stability during transportation: When the pipetting arm has a leveling function, if it is bumped or tilted during transportation, it will not cause internal liquid residue or mechanical structure deviation, affecting subsequent use. After repeated handling, the leveled pipetting arm will not cause key components (such as guides, seals) to wear or deform due to uneven force.

[0029] 2. Strong adaptability in exhibitions or demonstrations: When the exhibition stand floor is uneven or the temporary placement environment is unstable, the liquid level control of the pipette arm may be inaccurate, resulting in demonstration failure (such as liquid dripping, inconsistent liquid aspiration), and this problem is solved by adopting a leveling structure. It can quickly adapt to laboratory tables or display racks of different heights without affecting the convenience of operation.

[0030] 3. High accuracy: The pipetting arm is leveled so that the pipette tip is in vertical contact with the liquid surface to ensure accurate aspirated volume. Reduce residual volume when discharging liquid. For high-precision experiments (such as PCR, cell sorting), prevent poor repeatability caused by slight angle deviation.

[0031] 4. Strong long-term stability: The adoption of the leveling structure makes the mechanical structure evenly stressed, prevents the guide rail from being worn out, and ensures the Z-axis movement accuracy. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] To more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0033] Figure 1 Schematic diagram of the connection structure between the structure to be leveled and the leveling structure in the embodiment of the present application;

[0034] Figure 2 Exploded view of the connection structure between the structure to be leveled and the leveling structure in the embodiment of the present application;

[0035] Figure 3 Exploded view of the leveling structure in the embodiment of the present application;

[0036] Figure 4 Cross-sectional view of the connection structure between the reference point assembly and the universal leveling assembly in the embodiment of the present application.

[0037] Explanation of the reference numerals in the drawings:

[0038] 1 - Substrate;

[0039] 2 - Reference point assembly;

[0040] 21 - Second spherical washer group; 22 - Second bolt; 211 - First spherical washer; 212 - Second spherical washer; 23 - Third spherical washer group;

[0041] 3 - Universal leveling assembly;

[0042] 31 - Customized stud; 32 - Third spherical washer; 33 - First bolt; 34 - Wrench slot; 35 - First spherical washer group;

[0043] 4 - Connection plate;

[0044] 5 - Structure to be leveled. Detailed implementation manners

[0045] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, rather than all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.

[0046] In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "upper", "lower", "left", "right", "center", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present invention. In addition, the terms "first", "second", "third", etc. are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0047] In the description of the present invention, it should be noted that unless otherwise clearly specified and defined, the terms "installed", "set", "connected", "coupled", etc. should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0048] Embodiment 1

[0049] Please refer to Figures 1 to 4 , a leveling structure according to Embodiment 1 of the present invention includes a substrate 1, a reference point assembly 2, at least two universal leveling assemblies 3, and a connecting plate 4; one end of a structure 5 to be leveled is vertically connected to the connecting plate 4; the connecting plate 4 is angle-adjustably connected to the substrate 1 through the reference point assembly 2 and the universal leveling assemblies 3; the substrate 1 is connected to a frame; the reference point group and at least two of the universal leveling assemblies 3 are distributed at intervals; the leveling structure is applied to a liquid transfer device to achieve a leveling connection between the structure to be leveled and the frame.

[0050] In this embodiment, 3 universal leveling assemblies 3 are adopted; through the adoption of the reference point assembly 2 and two universal leveling assemblies 3, the angle adjustment between the connecting plate 4 and the substrate 1 is realized; the other universal leveling assembly 3 provides an auxiliary support function.

[0051] The universal leveling component 3 includes a customized stud 31, a third spherical washer 32, and a first bolt 33; an external thread is formed on the outer wall of the customized stud 31, a first through hole is formed along the axial direction, and an arc surface for cooperating with the third spherical washer 32 is formed at the top end of the customized stud 31; at least two stud mounting grooves are formed on one side of the base plate 1 adjacent to the connecting plate 4, and internal threads for cooperating with the external threads are formed on the inner walls of the stud mounting grooves; the customized stud 31 is screwed into the stud mounting grooves through the external threads and the internal threads; the third spherical washer 32 is disposed between the top end of the customized stud 31 and the connecting plate 4; at least two first connection holes are formed on the connecting plate 4; the first bolt 33 passes through the first connection holes, the third spherical washer 32, and the first through hole in sequence and is then screwed to the base plate 1.

[0052] An arc surface for cooperating with the third spherical washer 32 is formed at the top end of the customized stud 31, realizing universal adjustment of the angle of the connecting plate 4.

[0053] A first screw hole is formed on the bottom surface of the stud mounting groove of the base plate 1; the first bolt 33 passes through the first connection holes, the third spherical washer 32, and the first through hole in sequence and is then screwed to the first screw hole.

[0054] The first screw hole is used for screwing the first bolt 33 to the base plate 1, saving the connection space of the nut compared with nut connection.

[0055] A wrench groove 34 is formed at the top end of the customized stud 31, and the wrench groove 34 communicates with the first through hole.

[0056] The customized stud 31 is screwed into the stud mounting grooves through the external threads and the internal threads. The height of the customized stud 31 protruding from the base plate 1 can be adjusted by rotating the customized stud 31, cooperating with the reference point component 2 to realize the adjustment of the angle of the connecting plate 4 in the plane where the reference point component 2 is located. The adoption of the wrench groove 34 enables the convenient use of a wrench to rotate the customized stud 31 for height adjustment of the customized stud 31.

[0057] The customized stud 31 is screwed into the stud mounting grooves through the external threads and the internal threads. At the top end of the customized stud 31 (i.e., on one side of the arc surface), an internal hexagonal wrench groove 34 is provided. This wrench groove 34 is provided for rotating and adjusting the customized stud 31. The height of the customized stud 31 protruding from the base plate 1 can be adjusted by rotating the customized stud 31 through the cooperation of a wrench and the wrench groove 34, cooperating with the reference point component 2 to realize the adjustment of the angle of the connecting plate 4 in the plane where the reference point component 2 is located.

[0058] The reference point assembly 2 includes a second spherical washer group 21 and a second bolt 22; the second spherical washer group 21 includes a first spherical washer 211 and a second spherical washer 212 that cooperate with each other; the first spherical washer 211 is fixed to one side of the substrate 1 adjacent to the connecting plate 4; the second spherical washer 212 cooperates with the first spherical washer 211 and is disposed between the first spherical washer 211 and the connecting plate 4; the connecting plate 4 forms a second connection hole; the second bolt 22 passes through the second connection hole, the second spherical washer 212, and the first spherical washer 211 in sequence and is screwed into a second screw hole formed in the substrate 1.

[0059] The adoption of the second spherical washer group 21 cooperates with the universal leveling assembly 3 to realize the universal adjustment of the angle of the connecting plate 4.

[0060] A pipetting device with a leveling structure according to an embodiment of the present invention includes the leveling structure described in this embodiment, the frame, and the structure 5 to be leveled; the substrate 1 is fixed to the frame; the structure 5 to be leveled is connected to the connecting plate 4; the structure 5 to be leveled includes a pipetting arm.

[0061] A leveling method based on the leveling structure described in this embodiment according to an embodiment of the present invention includes the steps:

[0062] S1: Start leveling the leveling structure in the state to be leveled. The leveling structure in the state to be leveled does not install the second bolt 22, the third spherical washer group 23, the first bolt, and the first spherical washer group 35.

[0063] S2: Move the connecting plate 4 close to the substrate 1 until the connecting plate 4 together with the second spherical washer 212 completely contacts the first spherical washer 211, and use a tooling or an angle measuring tool to adjust the connecting plate 4 to the position state that needs to be finally adjusted to.

[0064] S3: Install the second bolt 22 and the third spherical washer group 23, and lock the reference point assembly 2.

[0065] S4: Adjust a universal leveling component 3. Use a wrench to pass through the corresponding first connection hole of the universal leveling component 3 and one of the third spherical washers 32, and extend it into the wrench groove 34 at the top of the customized stud 31. Then rotate the hex wrench to drive the customized stud 31 to rotate, and adjust the height of the customized stud 31 protruding from the substrate 1 until the arc surface at the top of the customized stud 31 is completely in contact with the arc surface of the third spherical washer 32. By default, the customized stud 31 is installed at the bottom in the stud installation groove on the substrate 1. Therefore, in this adjustment, usually the customized stud 31 is protruded more relative to the substrate 1. Additionally, a torque wrench can be used to determine whether the arc surfaces are completely in contact.

[0066] S5: Assemble the first spherical washer group 35 and the first bolt 33 of the current universal leveling component 3. The first spherical washer group 35 is disposed between the side of the connecting plate 4 away from the substrate 1 and the end of the first bolt 33. Lock the first bolt 33.

[0067] S6: Repeat steps S4 and S5 to adjust the remaining universal leveling components 3 in sequence until all the universal leveling components 3 are adjusted.

[0068] Embodiment 2

[0069] A leveling structure according to Embodiment 2 of the present invention has basically the same structure as that of Embodiment 1, except that at least two first receiving grooves corresponding to the positions of the customized studs 31 are formed on the side of the connecting plate 4 adjacent to the substrate. The third spherical washers 32 and part of the customized studs 31 are received in the first receiving grooves.

[0070] A second receiving groove corresponding to the position of the first spherical washer 211 is formed on the side of the connecting plate 4 adjacent to the substrate 1. The second spherical washer 212 is wholly or partly received in the second receiving groove.

[0071] The adoption of the first receiving groove and the second receiving groove makes the structure between the connecting plate 4 and the substrate 1 more compact, improving the integration degree of the structure.

[0072] Embodiment 3

[0073] A leveling structure according to Embodiment 3 of the present invention has basically the same structure as that of Embodiment 2, except that a second through hole is formed on the bottom surface of the stud installation groove of the substrate 1. The first bolt 33 passes through the first connection hole, the third spherical washer 32, the first through hole and the second through hole in sequence and is screwed with a first nut.

[0074] The second bolt 22 passes through the second connection hole, the second spherical washer 212, and the first spherical washer 211 in sequence, and then passes through a third through hole formed in the substrate 1 and is screwed to a second nut.

[0075] Embodiment 4

[0076] A leveling structure according to Embodiment 4 of the present invention has basically the same structure as that of Embodiment 3, the difference being that an external hexagonal feature is formed on the outer side of the top end of the customized stud 31.

[0077] The adoption of the external hexagonal feature facilitates the adjustment of the height of the customized stud 31.

[0078] Embodiment 5

[0079] A leveling structure according to Embodiment 5 of the present invention is basically the same as that of Embodiment 3, the difference being that the universal leveling assembly 3 further includes a first spherical washer group 35; the first spherical washer group 35 is disposed between the side of the connecting plate 4 away from the substrate 1 and the end of the first bolt 33.

[0080] The reference point assembly 2 further includes a third spherical washer group 23; the third spherical washer group 23 is disposed between the side of the connecting plate 4 away from the substrate 1 and the end of the second bolt 22.

[0081] The first spherical washer group 35 is used to compensate for the angular deviation between the connecting plate 4 and the first bolt 33. The third spherical washer group 23 is used to compensate for the angular deviation between the connecting plate 4 and the second bolt 22.

[0082] Embodiment 6

[0083] A leveling structure according to Embodiment 6 of the present invention is basically the same as that of Embodiment 5, the difference being that in this embodiment, two universal leveling assemblies 3 are adopted.

[0084] The present invention has been described in detail above in conjunction with the embodiments in the accompanying drawings. Those of ordinary skill in the art can make various variations to the present invention according to the above description. Therefore, certain details in the embodiments should not constitute a limitation to the present invention, and the protection scope of the present invention will be defined by the scope defined in the appended claims.

Claims

1. A leveling structure, characterized in that, It includes a substrate (1), a reference point assembly (2), at least two universal leveling assemblies (3), and a connecting plate (4); one end of a structure to be leveled (5) is vertically connected to the connecting plate (4); the connecting plate (4) is angularly adjustably connected to the substrate (1) through the reference point assembly (2) and the universal leveling assemblies (3); the substrate (1) is connected to a frame; the reference point assembly (2) and at least two of the universal leveling assemblies (3) are distributed at intervals; the leveling structure is applied to a pipetting device and is used to achieve a leveling connection between the structure to be leveled (5) and the frame.

2. The leveling structure according to claim 1, characterized in that, The universal leveling assembly (3) includes a customized stud (31), a third spherical washer (32), and a first bolt (33); the outer wall of the customized stud (31) forms an external thread, a first through hole is formed along the axial direction, and the top end of the customized stud (31) forms an arc surface that cooperates with the third spherical washer (32); at least two stud mounting grooves are formed on one side of the substrate (1) adjacent to the connecting plate (4), and the inner wall of the stud mounting groove forms an internal thread that cooperates with the external thread; the customized stud (31) is screwed into the stud mounting groove through the external thread and the internal thread; the third spherical washer (32) is disposed between the top end of the customized stud (31) and the connecting plate (4); at least two first connection holes are formed on the connecting plate (4); the first bolt (33) sequentially passes through the first connection hole, the third spherical washer (32), and the first through hole and then is screwed to the substrate (1).

3. The leveling structure according to claim 2, characterized in that, The reference point assembly (2) includes a second spherical washer group (21) and a second bolt (22); the second spherical washer group (21) includes a first spherical washer (211) and a second spherical washer (212) that cooperate with each other; the first spherical washer (211) is fixed to one side of the substrate (1) adjacent to the connecting plate (4); the second spherical washer (212) cooperates with the first spherical washer (211) and is disposed between the first spherical washer (211) and the connecting plate (4); a second connection hole is formed on the connecting plate (4); the second bolt (22) sequentially passes through the second connection hole, the second spherical washer (212), and the first spherical washer (211) and then is screwed to a second screw hole formed on the substrate (1) or is screwed to a second nut after passing through a third through hole formed on the substrate (1).

4. The leveling structure according to claim 2, characterized in that, At least two first receiving grooves corresponding to the positions of the customized studs (31) are formed on one side of the connecting plate (4) adjacent to the substrate (1); the third spherical washers (32) and part of the customized studs (31) are received in the first receiving grooves.

5. The leveling structure according to claim 2, characterized in that, The substrate (1) forms a first screw hole at the bottom surface of the stud mounting groove; the first bolt (33) sequentially passes through the first connection hole, the third spherical washer (32) and the first through hole and then is screwed with the first screw hole; or the substrate (1) forms a second through hole at the bottom surface of the stud mounting groove; the first bolt (33) sequentially passes through the first connection hole, the third spherical washer (32), the first through hole and the second through hole and then is screwed with a first nut.

6. The leveling structure according to claim 2, wherein A wrench groove (34) is formed at the top end of the customized stud member (31), and the wrench groove (34) communicates with the first through hole.

7. The leveling structure according to claim 2, characterized in that The universal leveling assembly (3) further includes a first spherical washer group (35); the first spherical washer group (35) is disposed between the side of the connecting plate (4) away from the substrate (1) and the end of the first bolt (33).

8. The leveling structure according to claim 3, characterized in that A second receiving groove corresponding to the position of the first spherical washer (211) is formed on the side of the connecting plate (4) adjacent to the substrate (1); the second spherical washer (212) is wholly or partly received in the second receiving groove.

9. The leveling structure according to claim 3, characterized in that, The reference point assembly (2) further includes a third spherical washer group (23); the third spherical washer group (23) is disposed between the side of the connecting plate (4) away from the substrate (1) and the end of the second bolt (22).

10. A pipetting device with a leveling structure, characterized in that, It includes a leveling structure according to any one of claims 1-9, the frame and the structure to be leveled (5); the substrate (1) is fixed to the frame; the structure to be leveled (5) is connected to the connecting plate (4); the structure to be leveled (5) includes a pipetting arm.

11. A leveling method based on the leveling structure according to any one of claims 3-9, comprising the steps of: S1: Start leveling the leveling structure in a state to be leveled, and the leveling structure in the state to be leveled does not install the second bolt (22), the third spherical washer group (23), the first bolt (33) and the first spherical washer group (35); S2: Move the connecting plate (4) close to the substrate (1) until the connecting plate (4) together with the second spherical washer (212) completely contacts the first spherical washer (211), and use a tooling or an angle measuring tool to adjust the connecting plate (4) to the position state finally required to be adjusted to; S3: Install the second bolt (22) and the third spherical washer group (23), and lock the reference point assembly (2); S4: Adjust a universal leveling assembly (3), use a wrench to pass through the corresponding first connection hole of the universal leveling assembly (3) and a third spherical washer (32), drive the customized stud member (31) to rotate through the wrench, and adjust the customized stud member (31) to protrude from the plane of the substrate (1) until the arc surface at the top end of the customized stud member (31) completely contacts the arc surface of the third spherical washer (32); S5: Assemble the first spherical washer group (35) of the current universal leveling component (3) and the first bolt (33); the first spherical washer group (35) is padded between the side of the connecting plate (4) away from the substrate (1) and the end of the first bolt (33); lock the first bolt (33); S6: Repeat steps S4 and S5 to adjust the remaining universal leveling components (3) in sequence until all the universal leveling components (3) are adjusted.

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