Composition for treating rhinitis and / or infantile adenoid hypertrophy and application thereof

Abstract

The invention discloses a composition for treating rhinitis and / or infantile adenoid hypertrophy and application thereof.According to the composition, a traditional Chinese medicine composition composed of dragon bone, magnolia flower, radix angelicae, cocklebur fruit and borneol is combined with chlortrimeton for use, rhinitis, especially allergic rhinitis and chronic rhinitis can be treated, the treatment effect is remarkable, and the composition is free of toxic and side effects. In addition, the traditional Chinese medicine composition can also be used for effectively treating infantile adenoid hypertrophy caused by rhinitis.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical technology, and in particular, to a composition for treating rhinitis and / or pediatric adenoid hypertrophy and its application. Background Art

[0002] Rhinitis is an inflammatory disease inside the nose. The main symptoms include nasal congestion, itching, runny nose, and frequent sneezing. The causes are relatively complex, among which chronic rhinitis and allergic rhinitis are the high-incidence rhinitis. The main symptoms of chronic rhinitis are: nasal congestion, increased nasal secretions, turbinate hypertrophy, nasal swelling, olfactory hypoesthesia, etc., often accompanied by symptoms such as dizziness and headache, bringing great inconvenience and pain to the daily life of patients. At the same time, if chronic rhinitis is not effectively treated, it will also cause lesions in other parts of the body, leading to complications and causing multiple damages to the patient's body. Allergic rhinitis, also known as allergic rhinitis, belongs to a common chronic nasal mucosal disease, which is characterized by an excessive immune response to specific allergens. This reaction usually involves IgE antibodies in the immune system. Common allergens include pollen, dust mites, pet dander, mold spores, etc. When the above allergens enter the nasal cavity, a series of symptoms will occur. The main symptoms involved in allergic rhinitis include frequent and intense sneezing, runny nose, nasal congestion, nasal itching, red and itchy eyes, and itchy throat. At present, antihistamines are used to treat rhinitis to relieve symptoms, but the treatment effect is limited and it is easy to relapse. And for children with rhinitis, long-term or repeated rhinitis will cause the nasal cavity inflammation to continuously stimulate the adenoids, triggering immunoreactive hyperplasia; at the same time, the mouth breathing habit caused by nasal congestion will also reduce the "scouring effect" of nasal airflow on the adenoids, which is likely to cause pediatric adenoid hypertrophy, and currently there are few drugs for treating pediatric adenoid hypertrophy caused by rhinitis. Summary of the Invention

[0003] Therefore, based on the above background, the present invention provides a composition for treating rhinitis and / or pediatric adenoid hypertrophy and its application, which can not only effectively treat rhinitis, especially chronic rhinitis and allergic rhinitis, with remarkable treatment effects, but also effectively treat pediatric adenoid hypertrophy caused by rhinitis.

[0004] The technical solution provided by the present invention is as follows:

[0005] A composition for treating rhinitis and / or pediatric adenoid hypertrophy, by weight, is composed of the following raw materials:

[0006] 80 - 150 parts of dragon bone, 100 - 200 parts of magnolia flower, 80 - 150 parts of angelica dahurica, 120 - 250 parts of xanthium sibiricum, 10 - 50 parts of borneol, 0.3 - 1 part of chlorpheniramine maleate.

[0007] Preferably, by weight, it is composed of the following raw materials:

[0008] 120 parts of dragon bone, 180 parts of magnolia flower, 120 parts of angelica dahurica, 180 parts of xanthium sibiricum, 30 parts of borneol, 0.7 part of chlorpheniramine maleate.

[0009] Preferably, by weight, it is composed of the following raw materials:

[0010] 100 parts of dragon bone, 150 parts of magnolia flower, 120 parts of angelica dahurica, 200 parts of xanthium sibiricum, 30 parts of borneol, 0.7 part of chlorpheniramine maleate.

[0011] Based on the same inventive concept, the present invention also provides the use of the composition for treating rhinitis and / or pediatric adenoid hypertrophy in the preparation of drugs for treating rhinitis.

[0012] Furthermore, the rhinitis is chronic rhinitis or allergic rhinitis.

[0013] Furthermore, the symptoms of the rhinitis include postnasal drip.

[0014] Based on the same inventive concept, the present invention also provides the use of the composition for treating rhinitis and / or pediatric adenoid hypertrophy in the preparation of drugs for treating pediatric adenoid hypertrophy.

[0015] Furthermore, the pediatric adenoid hypertrophy is caused by rhinitis.

[0016] Based on the same inventive concept, the present invention also provides a drug for treating rhinitis and / or pediatric adenoid hypertrophy, which is made of the above-mentioned composition.

[0017] Furthermore, the drug is a nasal spray.

[0018] The beneficial effects achieved by the present invention are as follows:

[0019] The present invention combines a traditional Chinese medicine composition composed of dragon bone, magnolia flower, angelica dahurica, xanthium sibiricum, and borneol with chlorpheniramine maleate. The dragon bone soothes the nerves, and together with magnolia flower, angelica dahurica, xanthium sibiricum, and borneol, it clears nasal passages and has anti-inflammatory effects; chlorpheniramine maleate relieves and reduces the production of secretions such as nasal discharge and sputum. With multi-target binding, it can treat rhinitis, especially allergic rhinitis and chronic rhinitis, with remarkable treatment effects, and can also effectively treat pediatric adenoid hypertrophy caused by rhinitis. Specific embodiments

[0020] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the embodiments of the present invention. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts fall within the scope of protection of the present invention.

[0021] Embodiment 1: A composition for treating rhinitis and / or pediatric adenoid hypertrophy, by weight, is composed of the following raw materials:

[0022] 120 parts of dragon bone, 180 parts of magnolia flower, 120 parts of angelica dahurica, 180 parts of xanthium sibiricum, 30 parts of borneol, and 0.7 part of chlorpheniramine maleate.

[0023] The specific dosage is: 120 g of dragon bone, 180 g of magnolia flower, 120 g of angelica dahurica, 180 g of xanthium sibiricum, 30 g of borneol, and 0.7 g of chlorpheniramine maleate.

[0024] Embodiment 2: A composition for treating rhinitis and / or pediatric adenoid hypertrophy, by weight, is composed of the following raw materials:

[0025] 100 parts of dragon bone, 150 parts of magnolia flower, 120 parts of angelica dahurica, 200 parts of xanthium sibiricum, 30 parts of borneol, and 0.7 part of chlorpheniramine maleate.

[0026] Comparative Example 1:

[0027] The specific dosage is: 100 g of dragon bone, 150 g of magnolia flower, 120 g of angelica dahurica, 200 g of xanthium sibiricum, 30 g of borneol, and 0.7 g of chlorpheniramine maleate.

[0028] The compositions of Embodiment 1 and Embodiment 2 are prepared into nasal sprays. The specific preparation steps are as follows:

[0029] 1) After separately pulverizing dragon bone, magnolia flower, angelica dahurica, xanthium sibiricum, and borneol, mix them and pass through a 50-mesh sieve;

[0030] 2) Mix the chlorpheniramine maleate powder evenly with the traditional Chinese medicine powder in step 1) and load it into a spray bottle.

[0031] Usage method: Before use, the patient first blows out the nasal mucus, then insert the nozzle of the spray bottle 1 - 2 cm into the nostril, squeeze the medicine bottle forcefully, and spray the medicine powder thoroughly into the nasal cavity. Spray 5 - 6 times a day.

[0032] Clinical data:

[0033] (1) According to the standards of allergic rhinitis and chronic rhinitis in the "Expert Consensus on Rhinitis Classification, Diagnosis and Nasal Drug Therapy", 36 patients with rhinitis diagnosed by nasal endoscopy, aged between 18 and 51 years old, including 19 patients diagnosed with chronic rhinitis and 17 patients with allergic rhinitis. Among them, 5 chronic patients had the symptom of postnasal drip. The above patients were excluded from those with combined infectious diseases, combined chronic respiratory diseases and drug allergies; with the informed consent of the patients, the nasal spray prepared in Example 1 was used for treatment. After continuous treatment for 25 days, and then observed for 2 months, the curative effects were statistically analyzed.

[0034] Curative effect criteria (based on the "Diagnostic and Curative Effect Criteria for Traditional Chinese Medical Syndromes"):

[0035] Marked effect: All symptoms disappeared, and nasal endoscopy showed that the mucosal edema was reduced and did not relapse for 2 months;

[0036] Effective: All symptoms were alleviated, nasal endoscopy showed that the mucosal edema improved, and the number of rhinitis attacks decreased;

[0037] Ineffective: All symptoms did not change or worsened.

[0038] Effective rate = (Marked effect + Effective) * 100 / Total number of people

[0039] The curative effect results are shown in Table 1:

[0040]

[0041] Among them, 2 chronic rhinitis patients with the symptom of postnasal drip had a marked effect, and the symptom of postnasal drip disappeared.

[0042] (2) According to the diagnostic criteria of adenoid hypertrophy in "Practical Otorhinolaryngology Head and Neck Surgery", 17 children aged between 3 and 10 years old diagnosed with adenoid hypertrophy were selected. Among them, after communicating with the parents and through diagnosis, 8 patients had chronic rhinitis combined with adenoid hypertrophy. The above patients were excluded from those with extremely severe adenoid hypertrophy accompanied by dyspnea and drug allergies. With the informed consent and cooperation of the parents, the above children were treated with the nasal spray prepared from the composition of Example 1. After continuous treatment for 16 days, the curative effects were statistically analyzed.

[0043] Curative effect criteria (calculated by the modified Nimodipine method):

[0044] Marked effect: Clinical symptoms and signs disappeared, and the symptom score decreased by ≥ 95%;

[0045] Effective: Clinical symptoms and signs were significantly improved, and the symptom score decreased by ≥ 70% and not higher than 95%;

[0046] Ineffective: Clinical symptoms and signs were not significantly improved, or even worsened, and the symptom score decreased by < 30%.

[0047] Results: 6 cases showed marked efficacy, 9 cases showed efficacy, 2 cases were ineffective, and among the 7 cases of chronic rhinitis complicated with adenoid hypertrophy, 3 cases were classified as showing marked efficacy and 5 cases were classified as showing efficacy.

[0048] The present invention and its implementation manners have been described above. Such description is not restrictive. What is shown in the embodiments is only one of the implementation manners of the present invention, and the actual structure is not limited thereto. Generally speaking, if those of ordinary skill in the art are inspired by it and, without departing from the purpose of the present invention, design similar structural manners and embodiments to this technical solution without creative efforts, they shall fall within the protection scope of the present invention.

Claims

1. A composition for treating rhinitis and / or pediatric adenoidal hypertrophy, characterized in that, By weight, it is composed of the following raw materials: 80 - 150 parts of dragon bone, 100 - 200 parts of magnolia flower, 80 - 150 parts of angelica dahurica, 120 - 250 parts of xanthium sibiricum, 10 - 50 parts of borneol, 0.3 - 1 part of chlorpheniramine maleate.

2. The composition for treating rhinitis and / or pediatric adenoid hypertrophy according to claim 1, wherein By weight, it is composed of the following raw materials: 120 parts of dragon bone, 180 parts of magnolia flower, 120 parts of angelica dahurica, 180 parts of xanthium sibiricum, 30 parts of borneol, 0.7 part of chlorpheniramine maleate.

3. A composition for treating rhinitis and / or pediatric adenoid hypertrophy according to claim 1, characterized in that, By weight, it is composed of the following raw materials: 100 parts of dragon bone, 150 parts of magnolia flower, 120 parts of angelica dahurica, 200 parts of xanthium sibiricum, 30 parts of borneol, 0.7 part of chlorpheniramine maleate.

4. Use of a composition for treating rhinitis and / or pediatric adenoid hypertrophy according to any one of claims 1 to 3 in the preparation of a medicament for treating rhinitis.

5. The application according to claim 4, characterized in that, The rhinitis is chronic rhinitis or allergic rhinitis.

6. The application according to claim 4, wherein The symptoms of the rhinitis include postnasal drip.

7. Use of a composition for treating rhinitis and / or pediatric adenoid hypertrophy according to any one of claims 1 to 3 in the preparation of a medicament for treating pediatric adenoid hypertrophy.

8. The application according to claim 7, characterized in that, The pediatric adenoid hypertrophy is caused by rhinitis.

9. A drug for treating rhinitis and / or pediatric adenoidal hypertrophy, characterized in that, It is made from the composition according to any one of claims 1 to 3.

10. A drug for treating rhinitis and / or pediatric adenoid hypertrophy according to claim 9, characterized in that, The medicament is a nasal spray.

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