Liquid injection device and injection control method

Abstract

The application relates to a liquid injection device and an injection control method. A multi-channel control valve and each first flow rate sensor are arranged on an injection host and are electrically connected with an injection control device. The injection control device acquires a target concentration of mixed liquid medicine to determine a target proportion of each raw liquid medicine. A driving pump is started to make each raw liquid medicine pass through the multi-channel control valve, mixed and then output mixed liquid medicine. Each first flow rate sensor detects the current flow rate of the raw liquid medicine in the corresponding channel. If the current flow rate ratio of each channel is not matched with the target proportion, the multi-channel control valve is controlled to adjust the opening degree of the corresponding channel until the current flow rate ratio is consistent with the target proportion. The liquid injection device and the injection control method can collect the current flow rate of the raw liquid medicine in each channel in real time, reduce the concentration deviation of the mixed liquid medicine, control the cooperative work of the driving pump and the multi-channel control valve by the injection control device, improve the liquid mixing precision and enhance the contrast imaging effect.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a liquid injection device and an injection control method. BACKGROUND

[0002] In the medical field, syringe systems play an important role in the precise injection of liquid medicine or contrast medium during X-ray, nuclear magnetic resonance and ultrasonic diagnosis and treatment. Traditional syringe systems, such as the syringe and hose system disclosed in patent CN1013371068, control the pumping of liquid medicine or contrast medium into the human body by driving the pump.

[0003] With the development of technology, some improved solutions have been proposed, such as the syringe for injecting liquid and the control method disclosed in patent CN104689421B, which detects the pressure of the liquid delivered by the pump, integrates the pressure over time according to the pressure change curve, and determines the pressure integral. When the determined pressure integral exceeds the predetermined integral limit value, the pump is turned off or the pump power is reduced to avoid dangerous pressure in the injection system. The driving pump type high pressure syringe and the flow rate adjustment method disclosed in patent CN117919548A control module can adjust the delivery pressure value to control the speed of the delivered liquid medicine, so that the speed of the injection module delivering liquid medicine is reduced or increased. Patent CN115300708A describes a full-automatic contrast injection instrument injection speed self-adaptive adjustment device and adjustment method, which realizes the matching of injection rate and injection pressure, ensures the completion of injection total amount, and controls and adjusts the injection rate when the injection pressure is abnormal, thereby ensuring the injection effect.

[0004] Currently, the above-mentioned prior art solutions mainly focus on the influence of injection pressure on the injection process or flow rate, ignoring an important requirement in clinical application. In actual clinical operation, different concentrations of contrast medium are often required, and the factory concentration of contrast medium is usually a standard value, which requires mixing with physiological saline to achieve different concentrations of development effect. However, most traditional solutions rely on on-off control of the injection amount of the syringe, which lacks flexibility and cannot meet the needs of clinical diversification of mixing ratio. SUMMARY

[0005] Therefore, it is necessary to provide a liquid injection device, an injection control method and an injection control device that can more accurately control different concentrations of liquid medicine.

[0006] A liquid injection device, comprising an injection main machine, a driving pump, a multi-channel control valve, a first flow rate sensor and an injection control device, the driving pump is arranged on the injection main machine, and the driving pump is used to provide power for the delivery of the drug liquid; the multi-channel control valve is arranged on the injection main machine, and the multi-channel control valve is located in front of the pumping of the driving pump, and the multi-channel control valve is used to control the opening size of the output channel of each drug liquid; the first flow rate sensor is arranged on the injection main machine, and the number of the first flow rate sensor is at least two, and each first flow rate sensor is used to detect the current output flow rate of the corresponding drug liquid; the multi-channel control valve and each first flow rate sensor are electrically connected with the injection control device, and the injection control device is used to control the multi-channel control valve to adjust the opening of each channel according to the target proportion of each original drug liquid under the target concentration, so that the current flow rate ratio detected by each first flow rate sensor matches the target proportion.

[0007] In one of the embodiments, the liquid injection device further comprises a second flow rate sensor arranged behind the pumping of the driving pump; the second flow rate sensor is used to detect the current flow rate of the drug liquid pumped by the driving pump, and the injection control device is used to control the operation of the injection control device and / or the driving pump according to the detection data of the second flow rate sensor.

[0008] In one of the embodiments, the liquid injection device further comprises a temperature compensator arranged in front of the pumping of the driving pump, the temperature compensator is electrically connected with the injection control device, and the temperature compensator is controlled to heat the drug liquid entering the driving pump.

[0009] In one of the embodiments, the multi-channel control valve is a four-way servo proportional valve; and / or

[0010] The liquid injection device further comprises a pressure collector arranged behind the pumping of the driving pump, and the pressure collector is used to facilitate the collection of the pipeline pressure in the infusion process; and / or

[0011] The liquid injection device further comprises an ultrasonic bubble sensor used to detect the bubble condition in the infusion pipeline.

[0012] An injection control method, comprising:

[0013] Obtaining the target concentration of the mixed drug liquid, and obtaining the target proportion of each original drug liquid according to the target concentration;

[0014] Controlling the multi-channel control valve to open, and obtaining the current flow rate of each channel original drug liquid;

[0015] determining whether the current flow rate ratio of each channel of the original drug solution matches the target proportion;

[0016] If not, adjusting the opening degree of the corresponding channel of the multi-channel control valve until the current flow rate ratio matches the target proportion.

[0017] In one embodiment, adjusting the opening degree of the corresponding channel of the multi-channel control valve until the current flow rate ratio matches the target proportion includes:

[0018] Increasing the opening degree of the channel with a large proportion of the original drug solution and / or decreasing the opening degree of the channel with a small proportion of the original drug solution of the multi-channel control valve until the current flow rate ratio matches the target proportion.

[0019] In one embodiment, the injection control method further includes:

[0020] Obtaining the initial temperature of the original drug solution and the current environmental temperature, and evaluating the current viscosity of the mixed drug solution according to the current infusion duration, the current environmental temperature, the initial temperature, and the target concentration;

[0021] Obtaining the current output flow rate of the mixed drug solution, and determining whether the deviation between the current output flow rate and the target flow rate is greater than or equal to a preset threshold value;

[0022] If so, obtaining the target opening degree of the multi-channel control valve according to the target flow rate and the current viscosity of the mixed drug solution;

[0023] Adjusting the current opening degree of each channel of the multi-channel control valve to the target opening degree.

[0024] In one embodiment, determining whether the deviation between the current output flow rate and the target flow rate is greater than or equal to a preset threshold value further includes:

[0025] If it is determined that the deviation between the current output flow rate and the target flow rate is less than the preset threshold value, or the opening degree of any channel of the multi-channel control valve reaches the maximum adjustment value, obtaining the target rotation speed of the drive pump according to the target flow rate, the current viscosity of the mixed drug solution, and the current opening degree of the multi-channel control valve;

[0026] Adjusting the current rotation speed of the drive pump to the target rotation speed.

[0027] In one embodiment, adjusting the current rotation speed of the drive pump to the target rotation speed includes:

[0028] Calculating the adjusted pipeline pressure according to the target rotation speed and the current viscosity of the mixed drug solution;

[0029] If the calculated pipeline pressure is less than the preset maximum pressure, adjusting the current speed of the drive pump to the target speed is performed.

[0030] If the calculated pipeline pressure is greater than or equal to the preset maximum pressure, adjusting the current speed of the drive pump to the target speed is not performed.

[0031] In one embodiment, the injection control method further comprises:

[0032] Obtaining a current pressure value of the pipeline;

[0033] If the current pressure value is greater than or equal to the preset maximum pressure, triggering the control of the drive pump to reduce the speed and / or the control of the multi-way control valve to reduce the current opening degree;

[0034] Determining whether the current viscosity of the mixed drug solution is greater than a preset viscosity;

[0035] If yes, controlling the temperature compensator to start heating the drug solution until the current temperature of the drug solution reaches the preset temperature.

[0036] The liquid injection device and the injection control method set the original drug solution on the injection host, the multi-way control valve and each first flow rate sensor are electrically connected with the injection control device, the injection control device obtains a target concentration of the mixed drug solution, and determines a target proportion of each original drug solution according to the target concentration. The multi-way control valve opens and adjusts the opening degree of each original drug solution channel according to the target proportion of each original drug solution determined by the target concentration. The drive pump is started to pump out the mixed drug solution after the original drug solutions in each channel are mixed by the multi-way control valve. The current flow rate of the original drug solution in each channel is detected by a first flow rate sensor, and whether the current flow rate detected by each channel first flow rate sensor matches the target proportion is evaluated. If not, the opening degree of the corresponding channel of the multi-way control valve is adjusted until the current flow rate ratio and the target proportion are consistent. The liquid injection device and the injection control method described above are configured with flow rate sensors in each channel, which can real-time collect the current flow rate of the original drug solution in each channel and dynamically compare it with the target proportion, and real-time calibration can significantly reduce the concentration deviation of the mixed drug solution, meet the high-precision demand of the drug solution concentration in clinical practice, avoid the concentration error caused by the traditional fixed proportion mixing, and be suitable for various concentration drug solution proportioning scenes. Even if faced with pipeline resistance changes, pump speed fluctuations and other disturbances, the target proportion can be maintained through feedback adjustment to ensure the stability of the mixed drug solution concentration. The coordinated work of the injection control device in controlling the drive pump and the multi-way control valve improves the whole process automation and operation efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0037] The accompanying drawings, which form a part of the present application, are intended to provide further understanding of the present application and are incorporated herein in

[0038] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the accompanying drawings needed to be used in the embodiments description will be briefly introduced. Obviously, the accompanying drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0039] In addition, the drawings are not drawn in 1:1 scale, and the relative sizes of the various elements are only exemplarily drawn in the drawings, and are not necessarily drawn in true scale.

[0040] Figure 1 A structural block diagram of a liquid injection device in an embodiment.

[0041] Figure 2 A structural schematic diagram of a liquid injection device shown in Figure 1

[0042] A structural schematic diagram of a multi-path control valve in Figure 3 Figure 1

[0043] Figure 4 A sectional view of a multi-path control valve shown in Figure 3

[0044] Figure 5 A structural schematic diagram of a control valve unit in Figure 3

[0045] A structural schematic diagram of a control valve unit in Figure 6 Figure 5

[0046] Figure 7 A flow chart of an injection control method in an embodiment.

[0047] Figure 8 A flow chart of a mixed liquid concentration regulation method in an embodiment.

[0048] Figure 9 A flow chart of an injection control method in another embodiment.

[0049] Explanation of reference signs:

[0050] ​​​​​Liquid injection device 10; injection main machine 110; pipeline arrangement groove 112; drive pump 120; multi-pass control valve 130; guide 131; guide hole 1312; limiting hole 214; control valve unit 132; drive piece 133; pushing piece 134; linkage 135; first linkage part 1351; second linkage part 1352; rotating part 1353; first flow rate sensor 140; ultrasonic bubble sensor 150; pressure collector 160; particle filter 170. DETAILED DESCRIPTION

[0051] In order to make the above objectives, features and advantages of the present application more apparent, specific embodiments of the present application are described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. However, the present application can be practiced in a variety of ways other than those described herein without departing from the spirit of the present application, and it is understood that similar modifications can be made by those skilled in the art in the light of the foregoing description. Therefore, the present application is not limited to the following disclosed specific embodiments.

[0052] Reference Figure 1 and Figure 2 In an embodiment of the present application, the liquid injection device 10 comprises an injection main machine 110, a drive pump 120, a multi-pass control valve 130, a first flow rate sensor 140, and an injection control device. The drive pump 120 is arranged on the injection main machine 110 and is used to provide power for the delivery of the drug solution. The multi-pass control valve 130 is arranged on the injection main machine 110 and is located in front of the drive pump 120. The multi-pass control valve 130 is used to control the opening size of each output passage of the drug solution. The first flow rate sensor 140 is arranged on the injection main machine 110, and the number of the first flow rate sensor 140 is at least two. Each first flow rate sensor 140 is used to detect the current output flow rate of the corresponding drug solution. The multi-pass control valve 130 and each first flow rate sensor 140 are electrically connected to the injection control device. The injection control device is used to control the multi-pass control valve 130 to adjust the opening of each passage according to the target proportion of each raw drug solution under the target concentration, so that the current flow rate ratio detected by each first flow rate sensor 140 matches the target proportion.

[0053] In use, the original liquid medicine is arranged on the injection main machine 110, the multi-path control valve 130 and each first flow rate sensor 140 are electrically connected with the injection control device, the injection control device obtains the target concentration of the mixed medicine, and the target proportion of each original liquid medicine is determined according to the target concentration. The multi-path control valve 130 opens and adjusts the opening degree of each original liquid medicine channel according to the target proportion of each original liquid medicine determined according to the target concentration. The driving pump 120 is started to pump out the mixed medicine after the original liquid medicine of each channel is mixed by the multi-path control valve 130. The current flow rate of the original liquid medicine of each channel is detected by a first flow rate sensor 140, and whether the current flow rate detected by each channel first flow rate sensor 140 matches the target proportion is evaluated. If not, the opening degree of the corresponding channel is adjusted by controlling the multi-path control valve 130, until the current flow rate ratio and the target proportion are consistent.

[0054] In an embodiment, the liquid injection device 10 further comprises a second flow rate sensor arranged behind the driving pump 120; the second flow rate sensor is used to detect the current flow rate of the medicine pumped by the driving pump 120, and the injection control device is used to control the operation of the injection control device and / or the driving pump 120 according to the detection data of the second flow rate sensor. By arranging the second flow rate sensor, the flow rate of the mixed medicine, i.e. the flow rate of the medicine entering the patient's body, can be monitored in real time, so as to ensure that the flow rate is relatively constant.

[0055] In an embodiment, the liquid injection device 10 further comprises an ultrasonic bubble sensor 150, which can be used to detect whether there is a bubble in the infusion pipeline to ensure the safety of the infusion process. Specifically, the number of ultrasonic bubble sensors 150 is multiple, and the ultrasonic bubble sensor 150 is arranged at the medicine output port to detect whether there is medicine output. Specifically, the ultrasonic bubble sensor 150 is arranged at the output end of the driving pump 120 to detect whether there is a bubble in the medicine after passing through the driving pump 120. Specifically, the ultrasonic bubble sensor 150 is arranged before the pipeline into the patient to finally confirm whether there is a bubble in the medicine input into the patient. By arranging the ultrasonic bubble sensor 150 at multiple positions, the bubble condition can be detected at multiple positions in the pipeline through which the medicine flows, and the safety of the infusion process is ensured.

[0056] In an embodiment, the liquid injection device 10 further comprises a pressure collector 160. The pressure collector 160 is arranged to collect the pressure of the liquid in the liquid injection device 10. The pressure collector 160 is arranged to collect the pressure of the liquid in the liquid injection device 10 to avoid the liquid injection device 10 to inject the liquid to the patient at a too high pressure. In an embodiment, the pressure collector 160 is arranged at the back of the driving pump 120. In another embodiment, the pressure collector 160 is arranged between the driving pump 120 and the ultrasonic bubble sensor 150 arranged at the back of the driving pump 120. In another embodiment, the pressure collector 160 is arranged between the two ultrasonic bubble sensors 150 arranged at the back of the driving pump 120. In an embodiment, the pressure collector 160 is arranged on the liquid injection device 10. In another embodiment, the pressure collector 160 is arranged on the injection host 110.

[0057] In an embodiment, the liquid injection device 10 further comprises a particle filter 170. The particle filter 170 is arranged to filter and separate the particles in the liquid. In an embodiment, the particle filter 170 is arranged on the liquid injection device 10.

[0058] In an embodiment, the liquid injection device 10 further comprises a temperature compensator. The temperature compensator is arranged at the front of the driving pump 120. The temperature compensator is electrically connected to the injection control device. The temperature compensator is controlled to heat the liquid in the driving pump 120. The temperature compensator is arranged to heat the liquid in the liquid injection device 10 at a low temperature environment. The temperature compensator is arranged to increase the viscosity of the liquid in the liquid injection device 10. The temperature compensator is arranged to reduce the possibility that the liquid injection device 10 injects the liquid to the patient at a too high pressure or a too low flow rate.

[0059] In an embodiment, the temperature compensator comprises a first heater. The injection host 110 is provided with a liquid arrangement slot 112. The first heater is arranged in the liquid arrangement slot 112. The liquid arrangement slot 112 is arranged to arrange the liquid in the liquid injection device 10. The first heater is arranged to heat the liquid in the liquid arrangement slot 112. In an embodiment, the liquid arrangement slot 112 is arranged at the front of the multi-way control valve 130. In another embodiment, the first heater is arranged at another position at the front of the driving pump 120.

[0060] Further, the temperature compensator comprises a second heater. The injection host 110 is provided with a medicine shelf. The second heater is arranged on the medicine shelf. The second heater is arranged to heat or keep the temperature of the medicine arranged on the medicine shelf.

[0061] Referring to Figures 3 to 6In an embodiment, the multi-channel control valve 130 comprises a guide 131 and a control valve unit 132. The guide 131 is internally formed with a guide hole 1312. The control valve unit 132 is located at one side of the guide 131. The control valve unit 132 comprises a driving member 133, a pushing member 134, and a linkage member 135. The pushing member 134 is arranged in the guide hole 1312 and is movable in the guide hole 1312. The linkage member 135 is rotatably installed on the guide 131. One of the driving member 133 and the pushing member 134 is in sliding connection with the linkage member 135 and is rotatable relative to the linkage member 135, and the other is in rotational connection with the linkage member 135. The distance between the pushing member 134 and the linkage member 135 at the connection position of the guide 131 is smaller than the distance between the driving member 133 and the linkage member 135 at the connection position of the guide 131. The driving member 133 is controlled to push the linkage member 135 to swing, so as to drive the pushing member 134 to move in the guide hole 1312. In the embodiment, the control valve unit 132 is arranged on the injection main machine 110. The guide 131 is arranged at the pipeline arrangement groove 112, so that the guide hole 1312 is in opposite communication with the pipeline arrangement groove 112. The pushing member 134 can extend out of the guide hole 1312 into the pipeline arrangement groove 112.

[0062] In use, the infusion pipeline is arranged in the pipeline arrangement groove 112. The driving member 133 drives the pushing member 134 to move in the guide hole 1312 through the linkage member 135. The pushing member 134 is used to extrude the infusion pipeline to control the liquid flow area, so as to flexibly adjust the liquid flow rate or concentration ratio, and meet the diversified fluid control requirements in the diagnosis and treatment process. Since the distance between the pushing member 134 and the linkage member 135 at the connection position of the guide 131 is smaller than the distance between the driving member 133 and the linkage member 135 at the connection position of the guide 131, when the driving member 133 drives the linkage member 135 to move a large stroke, the pushing member 134 only generates a small displacement. The precise control of the moving distance of the pushing member 134 is realized by reducing the driving range, so as to realize the precise extrusion of the infusion pipeline. The above multi-channel control valve 130 converts the "large stroke input" of the driving member 133 into the "small stroke output" of the pushing member 134 through the lever structure design of the linkage member 135. In combination with the linear guide function of the guide 131, the precise control of the extrusion degree of the infusion pipeline in a small range is realized, the control precision of the liquid flow rate or concentration ratio is effectively improved, and the safety and effectiveness of the diagnosis and treatment process are ensured. Meanwhile, the layout design of the linkage member 135 makes the installation position of the pushing member 134 correspond to different positions of the pipeline arrangement groove 112 flexibly, and the compatibility is strong.

[0063] In the embodiment, the linkage 135 is a rod-shaped structure, one end of the linkage 135 is a rotating part 1353, the other end is a first linkage part 1351, and the part between the two ends is formed as a second linkage part 1352. The rotating part 1353 is rotatably installed on the guide 131, one end of the pushing piece 134 is inserted into the guide hole 1312, and the other end is rotatably connected with the second linkage part 1352. The driving piece 133 is rotatably connected with the first linkage part 1351 and can slide on the first linkage part 1351.

[0064] In the embodiment, the driving piece 133 can be a linear motor. In other embodiments, the driving piece 133 can also be an electromagnet, a hydraulic rod, or other mechanisms capable of driving the linkage 135 to swing.

[0065] In an embodiment, the number of control valve units 132 is at least two, the guide 131 is provided with guide holes 1312 consistent with the number of control valve units 132, and the pushing piece 134 of each control valve unit 132 is inserted into a guide hole 1312. By providing at least two control valve units 132, the synchronous control of at least two infusion pipelines can be realized, so as to realize the mixing of the liquid medicine in the at least two infusion pipelines according to the set proportion, and realize the proportioning of liquid medicines with different concentrations.

[0066] In the embodiment, the number of control valve units 132 is three, the guide 131 is provided with three guide holes 1312 arranged at intervals, and the pushing piece 134 of each control valve unit 132 is inserted into a guide hole 1312. The synchronous control of the liquid medicines in three infusion pipelines can be realized. Specifically, two control valve units 132 are arranged side by side, and the linkage 135 of the other control valve unit 132 is located between the linkages 135 of the two control valve units 132, so that the pushing pieces 134 of the three control valve units 132 are arranged close to each other. By arranging the three linkages 135, the driving piece 133 and the pushing piece 134 are arranged in a triangular shape, so that the structure of the multi-way control valve 130 is more compact, and the space occupied by the injection host 110 is reduced.

[0067] In the embodiment, the driving pump 120 is a peristaltic pump.

[0068] In the present application, the terms "first", "second" appear, which are only used for description purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features. Therefore, the features defined as "first" and "second" can explicitly or implicitly include at least one of the features. In the description of the present application, if the term "multiple" appears, the meaning of "multiple" is at least two, such as two, three, etc., unless otherwise specifically limited.

[0069] In the present application, unless specifically defined and limited otherwise, if the terms "mount", "connect", "connect", "fix" and the like appear, these terms should be interpreted in a broad sense. For example, it can be fixedly connected, or it can be detachably connected, or it can be integrated; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the internal communication of two elements or the interaction relationship between two elements, unless otherwise specifically limited. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0070] Reference Figure 7 and Figure 8 In one embodiment, the injection control method provided by the present application can be applied to the liquid injection device 10 as shown in Figure 1 and 2 Specifically, an injection control method is provided, comprising the following steps:

[0071] Step S110, obtaining the target concentration of the mixed drug solution, and obtaining the target proportion of each raw drug solution according to the target concentration.

[0072] Specifically, the target flow rate V set and the preset maximum pressure P max of the mixed drug solution are set. The target flow rate and the preset maximum pressure can be determined according to the patient's condition, or can be determined according to the drug solution used. The initial temperature T0 of the raw drug solution and the target concentration C of the mixed drug solution are obtained. According to the initial temperature T0 and the target concentration C, the initial viscosity of the mixed drug solution is obtained as μ0, and the initial opening A0 of the multi-channel control valve 130 and the initial speed S0 of the drive pump 120 are solved according to the target flow rate V set and μ0, while ensuring that the initial pressure P0 < P max In the present embodiment, the initial opening of the multi-channel control valve 130 can be the opening of each channel combined. The opening proportion of each channel is allocated according to the target proportion of each raw drug solution, so that the sum of the initial openings of each channel is consistent with the initial opening A0 of the multi-channel control valve 130.

[0073] Step S120, control the multi-channel control valve 130 to open, and obtain the current flow rate of each channel raw drug solution. Specifically, the first flow rate sensor 140 is arranged between the raw drug solution installation position and the multi-channel control valve 130 to detect the outflow flow rate of each raw drug solution.

[0074] Step S130, judging whether the current flow rate ratio of each channel raw drug solution matches the target proportion;

[0075] Step S140: If not, control the multi-channel control valve 130 to adjust the opening of the corresponding channel until the current flow rate ratio is consistent with the target ratio.

[0076] Specifically, the multi-channel control valve 130 is controlled to increase the opening of the channel with a higher proportion of the original drug solution and / or decrease the opening of the channel with a lower proportion of the original drug solution until the current flow rate ratio matches the target ratio. In this embodiment, as... Figure 8 As shown, taking the mixing of two original drug solutions as an example, when the flow rate ratio detected by channels A and B is greater than the target proportion, the opening of channel B is increased to increase the flow rate in channel B, while the opening of channel A remains unchanged. When the opening of channel B has increased to the maximum adjustment value, the opening of channel A is decreased. Similarly, when the flow rate ratio detected by channels A and B is less than the target proportion, the opening of channel A is increased. In this embodiment, during adjustment, only the opening of one channel is increased to facilitate the evaluation of the adjusted flow rate ratio and to ensure the flow rate of the mixed drug solution pumped by drive pump 120. In other embodiments, when the flow rate ratio detected by channels A and B is greater than the target proportion, the opening of channel B can be increased while the opening of channel A is decreased simultaneously.

[0077] See also Figure 9 In one embodiment, the injection control method further includes:

[0078] Step S210: Obtain the initial temperature T0 and the current ambient temperature Ta of the original drug solution; and evaluate the current viscosity μ of the mixed drug solution based on the current infusion duration t, the current ambient temperature Ta, and the initial temperature T0.

[0079] Specifically, based on the current infusion duration t, the current ambient temperature Ta, and the initial temperature T0, the current mixed drug solution temperature T(t) is calculated as: T(t) = T a +(T0-T a )e -kt Where T(t) is the current temperature of the mixed medicine solution (°C), which decreases with time t and approaches the ambient temperature Ta; k is the heat loss coefficient, which is determined by the insulation performance of the medicine solution delivery pipeline, the intensity of environmental convection, etc. (unit: s-1).

[0080] In other embodiments, the current temperature of the mixed solution can also be obtained in real time using a temperature sensor. For example, the temperature of the mixed solution pumped by the drive pump 120 and downstream of the multi-channel control valve 130 can be obtained.

[0081] Specifically, based on the current temperature T(t) and target concentration C of the mixed solution, the current viscosity μ of the mixed solution is evaluated. The viscosity is positively correlated with concentration and negatively exponentially correlated with temperature. Further, the current viscosity μ is: Wherein: μ0 is the reference viscosity (Pa s) of the low-concentration drug solution at the reference temperature T0; a is the temperature sensitivity coefficient (related to the type of drug solution, a > 0 indicates that the viscosity increases with the decrease of temperature); b is the concentration sensitivity coefficient (b > 0 indicates that the viscosity increases with the increase of concentration). In this embodiment, the reference temperature T0 is the initial concentration of the original drug solution, usually 37°C.

[0082] In another embodiment, the current viscosity μ of the mixed drug solution can also be obtained by experiment. According to the corresponding relationship table of the viscosity μ of the drug solution and the current temperature T and concentration C of the drug solution obtained by experiment, the current viscosity μ is obtained by looking up.

[0083] In step S220, the current output flow rate of the mixed drug solution is obtained, and it is judged whether the deviation between the current output flow rate and the target flow rate is greater than or equal to a preset threshold. Specifically, the second flow rate sensor detects the current output flow rate V real of the mixed drug solution in real time, and calculates the deviation ΔV = V set -V real In this embodiment, the drug injection system is used for contrast agent injection, and in order to ensure the contrast effect, it is necessary to ensure that the injection flow rate is constant. If the injection flow rate is too fast, it will cause the patient to be uncomfortable, and if the injection flow rate is slow, it will affect the contrast effect.

[0084] In step S230, if yes, the target opening degree of the multi-channel control valve 130 is obtained according to the target flow rate and the current viscosity of the mixed drug solution.

[0085] Specifically, when the deviation |ΔV| > δ1, the opening degree of the multi-channel control valve 130 is adjusted first. By increasing the opening degree of the multi-channel control valve 130 to expand the pipe flow passage area and reduce the flow resistance, the flow rate is improved, the energy consumption of the driving pump 120 is reduced, and the purpose of rough adjustment of the flow rate is achieved. The multi-channel control valve 130 rapidly expands the flow passage under low load, and the driving pump 120 does not intervene temporarily, which can reduce the adjustment complexity.

[0086] Further, the target opening degree of the multi-channel control valve 130 can be calculated according to the formula: ; wherein, k V is the system structure constant (related to the pipe diameter, pipe length and driving pump 120 characteristics), V set is the target flow rate V and S is the initial speed S0 of the driving pump 120.

[0087] Step S240, adjust the current opening degree of each passage of the multi-pass control valve 130 to the target opening degree. It should be noted that the maximum opening degree of each passage cannot exceed the maximum adjustment value. In this embodiment, the maximum adjustment value is less than the maximum opening degree, for example, the maximum adjustment value can be 90% of the maximum opening degree, to avoid pressure loss or turbulence caused by full opening of the multi-pass control valve 130, while not opening the passage to the maximum, leaving adjustment space for subsequent adjustment. It should be noted that the multi-pass control valve 130 controls the opening degree of multiple passages, and the increase in the opening degree requires an increase in the opening degree of each passage, the sum of the opening degrees of each passage is A, and the flow rate ratio of each passage is kept unchanged.

[0088] In another embodiment, the opening degree of the multi-pass control valve 130 is increased by a preset step size ΔA, so that the opening degree of the multi-pass control valve 130 is increased from A0 to A. In other embodiments, PID control can also be used to adjust the opening degree of the multi-pass control valve 130.

[0089] In an embodiment, step S220, it is judged whether the deviation between the current output flow rate and the target flow rate is greater than or equal to a preset threshold value, and then further comprising:

[0090] Step S250, if it is judged that the deviation between the current output flow rate and the target flow rate is less than the preset threshold value, or the opening degree of any one passage of the multi-pass control valve 130 reaches the maximum adjustment value, then according to the target flow rate V set , the current viscosity μ of the mixed drug solution, and the current opening degree A of the multi-pass control valve 130, the target speed S of the driving pump 120 is obtained. When one of the passages of the multi-pass control valve 130 reaches the maximum adjustment value, the pump intervenes, and the linear characteristic of the driving pump 120 is used to accurately compensate and adjust the output flow rate of the drug solution. The multi-pass control valve 130 is used as an auxiliary fine adjustment, and the opening degree is reduced if necessary. Alternatively, if the deviation between the current output flow rate and the target flow rate is less than the preset threshold value, the driving pump 120 is adjusted to achieve the purpose of supplementary adjustment and fine adjustment.

[0091] Specifically, according to the current viscosity μ, the current opening degree A of the multi-pass control valve 130, and the target flow rate V set , the target speed S of the driving pump 120 is calculated.

[0092] Step S260, adjust the current speed of the driving pump 120 to the target speed.

[0093] Specifically, step S261, according to V set , the current viscosity μ of the mixed drug solution, the adjusted pipeline pressure is calculated.

[0094] Further, the pipeline pressure model is: P=P0+k p ​μ·S; wherein, P0 is the initial pressure of the pipeline before the speed adjustment of the driving pump 120, i.e. the initial pressure of the pipeline when the speed of the driving pump 120 is S0, k p is the pressure coefficient.

[0095] Step S262, if the calculated pipeline pressure P is less than the preset maximum pressure P max , the current speed S0 of the driving pump 120 is adjusted to the target speed S.

[0096] Further, the pressure PID controller is used to dynamically adjust the speed, and real-time feedback and PID compensation are performed, wherein the required speed S of the driving pump 120 is: In the embodiment, S base is S0; e p = P max -P real is the pressure deviation, i.e. the difference between the current pressure P real and the preset maximum pressure P max ; K p is the proportional adjustment parameter, which quickly responds to the pressure deviation and adjusts the pump speed; K i is the integral adjustment parameter, which eliminates long-term static errors, such as flow attenuation caused by hose deformation; and K d is the differential adjustment parameter, which suppresses instantaneous fluctuations caused by temperature mutations or concentration fluctuations.

[0097] In the embodiment, through real-time feedback of the pressure, it is ensured that P real does not exceed P max during the speed adjustment of the driving pump 120, so as to avoid pipeline rupture or patient injury. The PID algorithm is used to suppress pressure fluctuations and achieve stable control.

[0098] Step S263, if the calculated pipeline pressure is greater than or equal to the preset maximum pressure, the current speed of the driving pump 120 is not adjusted to the target speed. Even if the current mixed liquid flow rate is not up to standard, the speed of the driving pump 120 is not increased, or the speed of the driving pump 120 can be reduced and an alarm is given.

[0099] In an embodiment, the injection control method further comprises:

[0100] obtaining the current pressure value P real of the pipeline. The current pressure value P real of the pipeline can be detected during the entire adjustment and control process, so as to ensure the safety of the liquid delivery.

[0101] If the current pressure value P real is greater than or equal to the preset maximum pressure P maxWhen the pressure exceeds the preset maximum pressure P real , the control algorithm triggers the driving pump 120 to reduce the speed and / or the multi-way control valve 130 to reduce the current opening degree. For safety consideration, when the pressure exceeds the preset maximum pressure P max , the control algorithm triggers the driving pump 120 to reduce the speed and / or the multi-way control valve 130 to reduce the current opening degree to switch the drug solution delivery to the low flow rate mode.

[0102] In an embodiment, the current viscosity of the mixed drug solution is determined. The viscosity evaluation is used to determine whether the pressure exceeds the preset maximum pressure P

[0103] Specifically, when the current viscosity of the mixed drug solution is greater than the preset viscosity, the temperature compensator is controlled to heat the drug solution until the current temperature of the drug solution reaches the preset temperature. By heating the drug solution, the temperature of the drug solution is increased to reduce the viscosity of the drug solution. In other embodiments, the driving pump 120 can be controlled to reduce the speed and / or the multi-way control valve 130 can be controlled to reduce the current opening degree to ensure that the pipeline pressure P real does not exceed the preset maximum pressure P max .

[0104] In an embodiment, when the output temperature of the mixed drug solution is less than the preset temperature, for example, less than 30°C, the temperature compensator is enabled to heat the drug solution to maintain the output temperature of the mixed drug solution at 37±2°C.

[0105] In an embodiment, the pressure of the pipeline is monitored in real time, and when a sudden change in the pressure of the pipeline is detected, the pipeline is determined to be leaking, and the injection is immediately stopped and an alarm is sounded.

[0106] In an embodiment, the adjustment process of each injection can be recorded for predicting the optimal parameter combination in a similar scenario.

[0107] The injection control method described above is configured with a flow rate sensor for each channel to collect the current flow rate of the original drug solution of each channel in real time and dynamically compare the target proportion, and the real-time calibration capability can significantly reduce the concentration deviation of the mixed drug solution, meet the high-precision requirement of the drug solution concentration in clinical practice, avoid the concentration error caused by the traditional fixed proportion mixing, and be suitable for various concentration drug solution mixing scenarios. Even if the pipeline resistance changes, the pump speed fluctuates, and other disturbances are encountered, the target proportion can be maintained through feedback adjustment to ensure the stability of the concentration of the mixed drug solution. The coordinated work of the driving pump 120 and the multi-way control valve 130 controlled by the injection control device improves the whole process automation, improves the operation efficiency, improves the mixing precision of the drug solution during the peristaltic pump double-flow injection, and improves the contrast imaging effect.

[0108] The injection control method realizes hierarchical control. First, the flow rate is coarsely adjusted by the opening of the multi-path control valve 130, which has a small influence on the pipeline pressure and mainly influences the pipeline resistance. Then, the speed of the drive pump 120 is dynamically adjusted and corrected in combination with the pressure feedback to finely adjust the output flow rate of the liquid medicine, avoid overpressure, and ultimately ensure the stability of the output flow rate of the liquid medicine under the condition of changes in the viscosity of the liquid medicine. At the same time, the fast coarse adjustment of the multi-path control valve 130 can reduce the high-load operation time of the drive pump 120. The linear adjustment of the drive pump 120 compensates for the nonlinear error of the multi-path control valve 130 and, in combination with viscosity compensation, adapts to different liquid medicine characteristics and different viscosities of the liquid medicine.

[0109] It should be understood that, although Figures 7-9 the steps in the flowchart of the injection control method are displayed in sequence according to the arrows, these steps are not necessarily executed in the order indicated by the arrows. Unless otherwise explicitly stated herein, the execution of these steps is not strictly limited in sequence, and these steps can be executed in other orders. Moreover, Figures 7-9 at least part of the steps in the flowchart of the injection control method can include multiple steps or multiple stages, which are not necessarily executed at the same time, but can be executed at different times, and the execution sequence of these steps or stages is not necessarily sequential, but can be executed alternately or alternately with at least part of other steps or steps or stages in other steps.

[0110] In one embodiment, the injection control device comprises:

[0111] A concentration determination module is configured to obtain a target concentration of the mixed liquid medicine and obtain a target proportion of each original liquid medicine according to the target concentration.

[0112] A flow rate acquisition module is configured to obtain the current flow rate of each channel original liquid medicine.

[0113] A judgment module is configured to determine whether the current flow rate ratio of each channel original liquid medicine matches the target proportion.

[0114] An opening control module is configured to control the multi-path control valve 130 to adjust the opening of the corresponding channel until the current flow rate ratio matches the target proportion.

[0115] The specific limitations of the injection control device can be referred to the limitations of the injection control method described above, which will not be repeated here. Each module in the injection control device described above can be realized by software, hardware, and their combination. Each module described above can be embedded in or independent of the processor in the computer device in hardware form, or can be stored in the memory in the computer device in software form, so that the processor can call and execute the operations corresponding to each module.

[0116] Any combination of the technical features in the above-described embodiments can be made. For the sake of brevity, the foregoing description is not intended to be exhaustive or to limit the scope of the application to the precise form disclosed. Modifications and alterations can occur to others upon reading the description. It is intended that the scope of the application be measured by the breadth of the appended claims rather than the particulars of the foregoing description.

[0117] The above-described embodiments only express several implementation manners of the present application, and the description is relatively specific and detailed, but it should not be understood as a limitation on the patent scope of the application. It should be pointed out that, for ordinary skilled persons in the art, several modifications and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the patent protection scope of the present application should be subject to the appended claims.

Claims

1. A liquid injection device, characterized in that, The liquid injection device includes: Injection unit; A drive pump is mounted on the injection unit and is used to provide power for the delivery of the drug solution; A multi-channel control valve is installed on the injection unit and located in front of the drive pump. The multi-channel control valve controls the opening degree of each output channel of the drug solution. The multi-channel control valve includes a guide component and a control valve unit. A pipeline arrangement groove is provided on the injection unit, and the guide component is located at the pipeline arrangement groove, with a guide hole formed within the guide component that communicates with the pipeline arrangement groove. The control valve unit is installed on the injection unit and located on one side of the guide component. The control valve unit includes a drive component, a push component, and a linkage component. The pusher is inserted into the guide hole and can move within the guide hole; the linkage is rotatably mounted on the guide; one of the drive and the pusher is slidably connected to the linkage and can rotate relative to the linkage, while the other is rotatably connected to the linkage; the distance between the pusher and the linkage at the connection position on the guide is less than the distance between the drive and the linkage at the connection position on the guide; the drive is controlled to push the linkage to swing, thereby driving the pusher to move within the guide hole and extend from the guide hole into the pipeline arrangement groove; and the pusher is located near the drug mixture area. A first flow rate sensor is disposed on the injection unit, and the number of first flow rate sensors is at least two. Each first flow rate sensor is used to detect the current output flow rate of the corresponding drug solution; and The injection control device includes a multi-channel control valve and each of the first flow rate sensors electrically connected to it. The injection control device is used to control the multi-channel control valve to adjust the opening of each channel according to the target proportion of each original drug solution at the target concentration, so that the current flow rate ratio detected by each of the first flow rate sensors matches the target proportion.

2. The liquid injection device according to claim 1, characterized in that, The liquid injection device further includes a second flow rate sensor, which is disposed after the pumping of the drive pump; the second flow rate sensor is used to detect the current flow rate of the liquid medicine pumped by the drive pump, and the injection control device is used to control the operation of the injection control device and / or the drive pump based on the detection data of the second flow rate sensor.

3. The liquid injection device according to claim 1, characterized in that, The liquid injection device also includes a temperature compensator, which is disposed in front of the driving pump and electrically connected to the injection control device. The temperature compensator is controlled to heat the liquid entering the driving pump.

4. The liquid injection device according to any one of claims 1-3, characterized in that, The number of control valve units is three. The guide member has three spaced-apart guide holes. The pusher of each control valve unit passes through one guide hole. Two control valve units are arranged side-by-side facing each other, and the linkage of the third control valve unit is located between the linkages of the two control valve units, so that the pushers of the three control valve units are arranged close to each other; and / or The liquid injection device further includes a pressure sensor, which is located downstream of the driving pump and is used to facilitate the collection of tubing pressure during the infusion process; and / or The liquid injection device also includes an ultrasonic bubble sensor, which is used to detect air bubbles in the infusion line.

5. The liquid injection device according to any one of claims 1-3, characterized in that, The injection control device is used for: Obtain the target concentration of the mixed drug solution, and determine the target proportion of each original drug solution based on the target concentration; The multi-channel control valve is opened, and the current flow rate of the original drug solution in each channel is obtained through the first flow rate sensor; it is determined whether the current flow rate ratio of the original drug solution in each channel matches the target ratio; if not, the multi-channel control valve is controlled to adjust the opening of the corresponding channel until the current flow rate ratio detected by the first flow rate sensor matches the target ratio. The initial temperature and current ambient temperature of the original drug solution are obtained. Based on the current infusion duration, the current ambient temperature, the initial temperature, and the target concentration, the current viscosity of the mixed drug solution is evaluated. The current output flow rate of the mixed medicine solution is obtained by the second flow rate sensor, and it is determined whether the deviation between the current output flow rate and the target flow rate is greater than or equal to a preset threshold. If so, the target opening degree corresponding to the multi-channel control valve is obtained according to the target flow rate and the current viscosity of the mixed medicine solution. Control and adjust the current opening degree of each passage of the multi-pass control valve to the target opening degree.

6. The liquid injection device according to claim 5, characterized in that, The injection control device is used to control the multi-channel control valve to adjust the opening of the corresponding channel until the current flow rate ratio matches the target ratio, including: The injection control device is used to control the multi-channel control valve to increase the opening of the channel with a large proportion of original drug solution, and / or the injection control device is used to control the multi-channel control valve to decrease the opening of the channel with a small proportion of original drug solution, until the current flow rate ratio is consistent with the target proportion.

7. The liquid injection device according to claim 5, characterized in that, The injection control device is also used for: If the deviation between the current output flow rate and the target flow rate is less than a preset threshold, or the opening of any one of the channels in the multi-channel control valve reaches the maximum adjustment value, then the target rotational speed of the drive pump is obtained based on the target flow rate, the current viscosity of the mixed solution, and the current opening of the multi-channel control valve. Adjust the current speed of the drive pump to the target speed.

8. The liquid injection device according to claim 7, characterized in that, The injection control device is used to adjust the current rotational speed of the drive pump to the target rotational speed, including: Calculate the adjusted pipeline pressure based on the target rotation speed and the current viscosity of the mixed solution; If the calculated pipeline pressure is less than the preset maximum pressure, then the current speed of the drive pump is adjusted to the target speed. If the calculated pipeline pressure is greater than or equal to the preset maximum pressure, then the adjustment of the current speed of the drive pump to the target speed will not be performed.

9. The liquid injection device according to claim 5, characterized in that, The injection control device is also used for: Obtain the current pressure value of the pipeline; If the current pressure value is greater than or equal to the preset maximum pressure, then the control pump speed is reduced and / or the multi-way control valve is reduced to a lower current opening degree. Determine whether the current viscosity of the mixed solution is greater than the preset viscosity; If so, the temperature compensator is activated to heat the liquid medicine until the current temperature of the liquid medicine reaches the preset temperature.

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