Skin microenvironment simulator

Abstract

The invention discloses a skin microenvironment simulator which is composed of a microenvironment simulator body, a high-precision control module, a control system and a water supply system. Aiming at the defects in the prior art, the invention provides a device capable of simulating a human skin surface environment and constructing a multi-parameter dynamic change scene of a temperature field, a humidity field and an air flow field. The method has the characteristics and beneficial effects that by constructing a multi-parameter dynamic change scene of skin surface temperature, humidity and gas flow rate, the microenvironment change of a skin surface multi-physical field is really simulated; particularly, a constant-temperature cover is additionally arranged to control temperature and airflow environment changes, a novel three-layer simulated skin design is combined, and the complex temperature and humidity state adjusting function of the simulated skin surface from dryness to different humidity and from humidity to different dryness is achieved. And more real and reliable test conditions are provided for related researches, so that the performance of flexible electronic skin, sensors and electrode devices can be accurately evaluated and optimized.

Description

Technical Field

[0001] The present invention relates to a skin microenvironment simulator for simulating the physical fields of humidity, temperature, and air flow on the surface of human skin, and more particularly to a skin microenvironment simulator. Background Art

[0002] In recent years, wearable devices such as flexible electronic skins, sensors, and electrode devices have received extensive attention due to their important applications in the fields of medical health, human-computer interaction, and smart home. However, the performance testing of these devices usually relies on traditional testing methods in the laboratory environment, and it is difficult to accurately simulate the actual microenvironment on the skin surface during human wearing. The surface of human skin is a complex dynamic system, and its temperature, humidity, and air flow conditions will fluctuate significantly due to individual differences, environmental changes, and different usage scenarios. For example, in practical applications, electronic skins or sensors may need to work stably for a long time in a hot and humid environment caused by physiological activities such as sweating and breathing, and these factors pose extremely high requirements for the durability and accuracy of the devices.

[0003] In the prior art, Chinese Patent CN111239527A discloses a human body simulator for the reliability detection of patch-type flexible electronic monitoring devices, which focuses on solving the problems of troublesome, time-consuming, laborious, and high-cost reliability detection of existing patch-type flexible electronic monitoring devices, but does not consider the problem of the influence of simulating the hot and humid environment on the skin surface on the performance of patch devices. Chinese Patent CN116893625A designs an adaptive feedback simulation device and method for local active sweating of the human body under a low-pressure environment, and dynamically controls the sweating speed according to the change of the local skin temperature field of the human body to improve the simulation accuracy of the thermal physiological response of the human body under special low-pressure environments, but still cannot simultaneously realize the dynamic simulation of the temperature field, humidity field, and air flow field. This limitation makes it difficult for the experimental results to reflect the device performance under real usage conditions, restricting the further optimization and application promotion of device development.

[0004] The current technology mainly has the following defects: (1) Some existing simulation devices can provide partial temperature and humidity microenvironment regulation functions, but lack a dynamic simulation device that can simultaneously realize the temperature field, humidity field, and air flow field; (2) Most of the existing sweat regulation systems simulate the release process of skin sweat by simply opening holes at the sweating positions, and this single-point control method cannot truly restore the actual environment of sweat release on the human skin surface.

[0005] Therefore, there is an urgent need for a simulator that can simultaneously construct a multi-parameter dynamic microenvironment to accurately evaluate and optimize the performance of flexible electronic skins, sensors, and electrode devices. Such a simulator not only needs to have precise temperature and humidity control capabilities but also needs to support real-time adjustment and monitoring of air flow, so as to provide more realistic and reliable test conditions for related research. Summary of the Invention

[0006] The object of the present invention is to overcome the deficiencies of the prior art and provide a skin microenvironment simulator, which can simulate the humid and hot environment on the skin surface, construct a multi-parameter dynamic change scenario of temperature, humidity and gas flow rate on the skin surface; in particular, by adding a constant temperature cover to control the changes in temperature and air flow environment, combined with the structural design of the simulated skin, the state adjustment function of the skin surface from dry to different humidities and from wet to different dryness is realized; and a new combination scheme of a three-layer skin structure is designed to fully restore the complex change scenario of humidity and temperature on the human skin surface; provide more real and reliable test conditions for related research to accurately evaluate and optimize the performance of flexible electronic skin, sensors and electrode devices.

[0007] The present invention is realized by the following technical solutions:

[0008] A skin microenvironment simulator, which is composed of a microenvironment simulator, a high-precision control module, a control system and a water supply system;

[0009] The microenvironment simulator is installed on the bottom plate. The high-precision control module and the control system are both electrically connected to the microenvironment simulator. The water supply system is connected to the microenvironment simulator through a water pipe, and is used to construct the temperature field, humidity field and air flow field of the skin microenvironment, simulate the humid and hot environment and air flow environment on the skin surface, and realize the state adjustment of the skin state from dry to different humidities and from wet to different dryness;

[0010] The high-precision control module is installed on the left side of the microenvironment simulator, is connected to the microenvironment simulator and the water supply system, realizes precise control of the driving device in the microenvironment simulator, precise acquisition of the sensing device, and adaptive adjustment of temperature, humidity and wind speed, and is connected and communicates with the control system;

[0011] The control system is installed on a computer device, is connected and communicates with the high-precision control module, and realizes data acquisition and drive control of the high-precision control module;

[0012] The water supply system is installed on the right side of the microenvironment controller, is connected to the microenvironment simulator through a water pipe, realizes the delivery of the test liquid to the microenvironment simulator, and is electrically connected to the high-precision control module to realize the adaptive adjustment control of the water supply rate and water volume.

[0013] Furthermore, the microenvironment simulator includes a skin simulator body, a motion module, and a skin microenvironment chamber. The skin simulator body is installed on the bottom plate and is used to construct a humid and hot skin microenvironment, with the function of adjusting the skin temperature between 20 - 40°C and the relative humidity (RH) between 0 - 100%. The base of the motion module is installed on the motion support of the skin microenvironment chamber, and the motion mechanism is installed above the skin simulator body inside the skin microenvironment chamber. Through the motion control of the motion mechanism, the device clamping device can achieve three-dimensional movement on the surface of the skin simulator body. The skin microenvironment chamber has the function of opening and closing up and down. When opened, it can realize the installation and debugging of the skin simulator body and the motion module. When closed, it can construct a closed space including the skin simulator body and the motion module. The skin microenvironment chamber also has the function of adjusting the internal environmental temperature, humidity, and the surface wind speed of the skin simulator body.

[0014] Furthermore, the skin simulator body includes a skin module and a simulator module. The skin module is fixed at the top of the simulator module. The skin module has the functions of moisture permeability and heat conduction, and can realize the surface humidity and temperature environment of the human skin on the surface of the skin module through the simulator module. The skin module can be quickly disassembled and replaced according to different environmental requirements. The skin module includes a simulated skin rough layer, a unidirectional moisture conduction layer, and a moisture conduction layer. The simulated skin rough layer is installed on the top of the unidirectional moisture conduction layer, and the unidirectional moisture conduction layer is installed on the top of the moisture conduction layer. The simulated skin rough layer is used to simulate the rough structure of the human skin epidermis. The simulated skin rough layer has the characteristics of moisture permeability and heat conduction, and at the same time, the simulated skin rough layer can realize pressure sensing. The unidirectional moisture conduction layer has a unidirectional moisture conduction structure, which can realize the unidirectional liquid transfer from the moisture conduction layer to the simulated skin rough layer, but cannot realize the liquid transfer from the simulated skin rough layer to the moisture conduction layer. The moisture conduction layer has a microporous structure, which is used to control the transmission of the simulated skin sweat volume. The above-mentioned simulated skin rough layer, unidirectional moisture conduction layer, and moisture conduction layer can all be replaced with different sizes according to the required environment.

[0015] Furthermore, the simulated skin rough layer has the function of pressure sensing and can sense the pressure fluctuation of the object on the surface of the simulated skin rough layer. Humidity sensors and temperature sensors are arrayed between the simulated skin rough layer and the unidirectional moisture conduction layer, which are used to obtain the humid and hot environment parameters of the skin module and are used for the adaptive regulation of the temperature and humidity parameters of the simulator by the high-precision control module.

[0016] Furthermore, the simulator module is installed inside the skin microenvironment chamber. The upper end face of the simulator module is closely joined to the lower end face of the skin module. The simulator module has the functions of internal heating, humidifying, and transmitting physiological electrical signals. There is a heating module at the bottom of the simulator module to achieve constant-temperature heating of the internal space of the simulator. An artificial sweat gland module is installed at the top of the simulator module. The artificial sweat gland module consists of a water pipe fixing bracket and simulator water pipes. The simulator water pipes are fixed on the water pipe fixing bracket in a disc-shaped or snake-shaped manner. Micro-outlets are distributed in an array at a certain distance at the top of the simulator water pipes for the function of the artificial sweat gland pumping out sweat. The middle cavity of the simulator module is filled with agar or solid hydrogel material to maintain the temperature and humidity environment in the cavity of the simulator module. A reference electrode installation interface is provided on the left side wall of the simulator module to import the simulated physiological signals generated by the high-precision control module into the simulator module. A simulator water pipe interface is provided on the right side of the artificial sweat gland module to introduce the test solution in the water supply system. Temperature and humidity sensors are distributed in the middle cavity of the simulator module.

[0017] Furthermore, the motion module has a two-dimensional motion slide rail, a high-precision vertical push rod, a pressure acquisition module, a device clamping mechanism, and a temperature measurement device. The two-dimensional motion slide rail is installed on the base of the motion module and can achieve the function of free movement in the X and Y axis directions. The base of the high-precision vertical push rod is installed on the mounting seat of the two-dimensional motion slide rail, and a pressure acquisition module is installed at the top of the high-precision vertical push rod to achieve the motion adjustment of the motion module in the vertical direction. The device clamping mechanism is connected to the pressure acquisition module to collect the change in the contact pressure between the device and the skin module. The temperature measurement device is installed at the far end of the two-dimensional motion slide rail of the skin microenvironment chamber. The temperature measurement device is vertically corresponding to the surface of the skin module, and the temperature measurement device detects the surface temperature change of the simulated skin rough layer in the skin module from the top.

[0018] Furthermore, the skin microenvironment chamber is installed on the bottom plate, and a motion support is installed at the upper end of the skin microenvironment chamber as the installation base of the motion module. Airflow heating devices are respectively installed at the positions on the left and right sides of the skin microenvironment chamber that are at the same height as the skin simulator body to form a microfluidic field with adjustable parameters on the surface of the skin module. The front panel of the skin microenvironment chamber is made of transparent material, and the test changes inside the skin microenvironment chamber can be observed after closing the lid.

[0019] Furthermore, the high-precision control module includes a motion control module for the motion module, a control module for the temperature, humidity, and airflow heating device, a signal acquisition module for temperature, humidity, and gas flow rate, a physiological electrical signal generating device, and a high-precision signal acquisition device. The motion control module of the motion module is connected to the motion module in the skin microenvironment chamber and is used to control the high-precision three-dimensional motion of the motion module on the surface of the skin module. The control module for the temperature, humidity, and airflow heating device is used to control the heating module, airflow heating device, and water supply system installed in the skin microenvironment chamber and the skin simulator body to achieve adaptive adjustment of the above temperature, humidity, and airflow heating device. The signal acquisition module for temperature, humidity, and gas flow rate is used to collect the parameter signals of the temperature, humidity, and gas flow rate sensors installed in the skin microenvironment chamber and the skin simulator body. The physiological electrical signal generating device is connected to the reference electrode and is used to simulate human physiological electrical signals in the skin simulator body. The high-precision signal acquisition device is installed on the motion module and is used to test the signal acquisition performance of different devices.

[0020] Furthermore, the control system is installed on a computer device and is used to achieve data communication and drive control of the high-precision control module. The control system can realize real-time curve display and parameter analysis of temperature, humidity, and gas flow rate signals.

[0021] Furthermore, the water supply system includes a constant-temperature water storage tank, a high-precision peristaltic pump, a balance, and a housing. The constant-temperature water storage tank is installed on the balance, and an installation rack is installed on the top of the constant-temperature water storage tank for installing the high-precision peristaltic pump. The high-precision peristaltic pump is installed on the installation rack. The water inlet of the high-precision peristaltic pump is vertically inserted into the upper opening of the constant-temperature water storage tank to avoid contact with the outer wall of the constant-temperature water storage tank. The water outlet of the high-precision peristaltic pump is connected to the simulator water pipe interface on the right side of the sweat gland module simulation in the skin simulator body to continuously supply test liquid for the sweat gland module simulation and maintain the humidity environment in the skin microenvironment simulator. The balance is installed at the bottom of the housing, and the constant-temperature water storage tank is installed on the balance. The balance records the weight change of the constant-temperature water storage tank in real time and transmits the real-time data to the control system.

[0022] Furthermore, the high-precision peristaltic pump is connected to the high-precision control module and adjusts the test liquid delivery volume in real time according to the control instructions in the high-precision control module to achieve adaptive adjustment control of the water supply rate and water volume.

[0023] Compared with the prior art, the beneficial effects of the non-invasive bioelectric electrode performance testing system provided by the present invention include:

[0024] 1. It provides a skin microenvironment simulator that can simulate the hot and humid environment on the skin surface and construct a simulator for the multi-parameter dynamic microenvironment of temperature, humidity, and gas flow rate on the skin surface.

[0025] 2. By controlling the changes in temperature and airflow environment with an externally added constant temperature cover, and combining the structural design of the simulated skin, the state adjustment function of the simulated skin surface from dry to different humidities and from wet to different dryness levels is achieved.

[0026] 3. A novel structural design imitating human skin is provided. Through the combined design of a three-layer skin structure, the complex change scenarios of humidity and temperature on the human skin surface are fully restored.

[0027] 4. Provide more realistic and reliable test conditions for related research to accurately evaluate and optimize the performance of flexible electronic skin, sensors, and electrode devices. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The above and other objects, features, and advantages of the present invention will become more apparent by describing the embodiments of the present invention in more detail in conjunction with the accompanying drawings. The accompanying drawings herein are incorporated into the specification and form a part of the specification, showing embodiments consistent with the present invention, and are used together with the specification to explain the principles of the present invention and do not constitute a limitation to this application. In the drawings, the same reference numerals generally represent the same components or steps.

[0029] Figure 1 is an overall schematic diagram of a skin microenvironment simulator shown according to an exemplary embodiment;

[0030] Figure 2 is a schematic diagram of the microenvironment simulator of a skin microenvironment simulator shown according to an exemplary embodiment;

[0031] Figure 3 is a schematic diagram of the skin simulator body of a skin microenvironment simulator shown according to an exemplary embodiment;

[0032] Figure 4 is a top view of the sweat gland module imitation of a skin microenvironment simulator shown according to an exemplary embodiment;

[0033] In the figure: 1 microenvironment simulator; 101 motion bracket; 102 skin microenvironment chamber; 103 high-precision vertical push rod; 104 two-dimensional motion slide rail; 105 pressure acquisition module; 106 device clamping mechanism; 107 test device; 108 skin module; 1081 simulated skin rough layer; 1082 unidirectional moisture-conducting layer; 1083 moisture-conducting layer; 1084 skin module mounting bracket; 1085 gas flow rate sensor; 1086 temperature sensor; 1087 humidity sensor; 109 simulator module; 1091 simulator module housing; 1092 heating module; 1093 sweat gland simulation module; 1094 simulator water pipe; 1095 temperature and humidity sensor; 1096 simulator water pipe interface; 1097 reference electrode; 110 bottom plate; 111 air flow heating device; 112 temperature measurement device; 2 high-precision control module; 3 control system; 4 water supply system housing; 5 high-precision peristaltic pump; 6 high-precision peristaltic pump mounting bracket; 7 constant temperature water storage tank; 8 water pipe; 9 balance. Detailed implementation manners

[0034] The embodiments of the present invention will be described in detail below. The exemplary embodiments according to the present invention will be described in detail with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments of the present invention. It should be understood that the present invention is not limited by the exemplary embodiments described herein.

[0035] As Figure 1 shown, a skin microenvironment simulator of the present invention includes a microenvironment simulator 1, a high-precision control module 2, a control system 3 and a water supply system; wherein, the microenvironment simulator 1 is installed on a bottom plate 110, the high-precision control module 2 and the control system 3 are both electrically connected to the microenvironment simulator 1, and the water supply system is connected to the microenvironment simulator 1 through a water pipe 8, for realizing the construction of a simulated skin microenvironment temperature field, humidity field and air flow field, simulating the microenvironment of skin surface heat and humidity and air flow, and controlling the state adjustment of the skin state from dry to different humidities and from wet to different drynesses; the high-precision control module 2 is installed on the left side of the microenvironment simulator 1, and is connected to the microenvironment simulator 1 and the water supply system, realizing precise control of the driving device in the microenvironment simulator 1, precise acquisition of the sensing device, adaptive adjustment of temperature, humidity and air flow, and communicating with the control system 3 through a serial port; the control system 3 is installed on a computer device, and is connected to and communicates with the high-precision control module 2, realizing data acquisition and driving control of the high-precision control module 2; the water supply system is installed on the right side of the microenvironment controller 1, and is connected to the microenvironment simulator 1 through a water pipe 8, realizing the delivery of test liquid to the microenvironment simulator 1, and being electrically connected to the high-precision control module 2, realizing adaptive adjustment control of the water supply rate and water volume.

[0036] As Figure 2As shown, the microenvironment simulator 1 includes a skin simulator body, a motion module, and a skin microenvironment chamber 102. Among them, the skin simulator body is installed on the bottom plate 110, and the skin simulator body is used to construct a skin hot and humid microenvironment, with the functions of adjusting the skin temperature between 20 - 40°C and the relative humidity (RH) between 0 - 100%. The base of the motion module is installed on the motion bracket 101 of the skin microenvironment chamber 102, and the motion bracket 101 is fixedly installed on the bottom plate 110. The motion mechanism is installed above the skin simulator body inside the skin microenvironment chamber 102. The motion mechanism can move on the motion bracket 101 through the two-dimensional motion slide rail 104. Through the motion control of the motion mechanism, the device clamping mechanism 106 can perform three-dimensional space motion on the surface of the skin simulator body, including forward and backward, left and right, and up and down motions. The moving resolution is 20um, and the moving speed is adjustable between 0 - 350mm / min. The skin microenvironment chamber 102 has the function of opening and closing up and down. When opened, it can realize the installation and debugging of the skin simulator body and the motion module. When closed, it can construct a closed space including the skin simulator body and the motion module. The skin microenvironment chamber 102 also has the function of adjusting the internal environmental temperature, humidity, and the surface wind speed of the skin simulator body. The control system 3 adjusts the parameters in the skin microenvironment chamber 102 according to the environmental information collected by the high-precision control module 2 to ensure that the temperature, humidity in the skin microenvironment chamber 102, and the surface wind speed of the skin simulator body are maintained at the test preset values of the control system 3.

[0037] As Figure 2 , 3, as shown in Figure 4, the skin simulator body includes a skin module 108 and a simulator module 109; among them, the skin module 108 is fixed on the top of the simulator module 109. The skin module 108 has the functions of moisture permeability and heat conduction. The simulator module 109 realizes the surface humidity and temperature environment of the simulated human skin on the surface of the skin module 108. The skin module 108 can be quickly disassembled and replaced according to different test requirements; the skin module 108 includes a simulated skin rough layer 1081, a unidirectional moisture-conducting layer 1082, and a moisture-conducting layer 1083. The simulated skin rough layer 1081 is installed on the top of the unidirectional moisture-conducting layer 1082, and the unidirectional moisture-conducting layer 1082 is installed on the top of the moisture-conducting layer 1083; the simulated skin rough layer 1081 is used to simulate the rough structure of the human skin epidermis. The simulated skin rough layer 1081 has the characteristics of moisture permeability and heat conduction, and at the same time, the simulated skin rough layer 1081 has a pressure sensing function; the unidirectional moisture-conducting layer 1082 has a microcone structure with unidirectional moisture conduction, which can realize the unidirectional liquid transfer from the moisture-conducting layer 1083 to the simulated skin rough layer 1081, but cannot realize the liquid transfer from the simulated skin rough layer 1081 to the moisture-conducting layer 1083; the moisture-conducting layer 1083 has a microporous structure, which is used to control the transmission of the simulated skin sweat volume; the above-mentioned simulated skin rough layer 1081, unidirectional moisture-conducting layer 1082, and moisture-conducting layer 1083 can all be replaced with different sizes according to the required environment.

[0038] It should be noted that the above-mentioned simulated skin rough layer 1081 can be prepared by using materials with specifications such as 0.1um PTFE, 0.22um PP, or 0.45um MCE as the base material. At the same time, the simulated skin rough layer 1081 has piezoresistive sensor characteristics, which can realize the perception of the array pressure fluctuation of the object on the surface of the simulated skin rough layer 1081. When the device under test starts to contact the surface of the simulated skin rough layer 1081 through the motion module, the simulated skin rough layer 1081 can detect the contact position of the device under test, and at the same time collect the change in the pressure value received by the simulated skin rough layer 1081; when the test is completed and the device under test starts to separate from the surface of the simulated skin rough layer 1081 through the motion module, the simulated skin rough layer 1081 can detect the change in the pressure value at the separation position of the device under test, and can realize the state test of the moment of contact and separation between the device under test and the human skin; humidity sensors 1086 and temperature sensors 1087 are distributed in an array between the above-mentioned simulated skin rough layer 1081 and the unidirectional moisture-conducting layer 1082, which are used to obtain the hot and humid environment parameters of the skin module 108 and are used for the adaptive regulation of the temperature and humidity parameters of the simulator module 109 by the high-precision control module 2; the above-mentioned moisture-conducting layer 1083 can be a PTFE microporous membrane with different micropore sizes. In this embodiment, a 0.1um PTFE microporous membrane is selected.

[0039] In this embodiment, the above simulator module 109 is installed inside the skin microenvironment chamber 102. The upper end face of the simulator module 109 is tightly joined with the lower end face of the skin module 108. The simulator module 109 has the functions of internal heating, humidifying and transmitting physiological electrical signals of the simulator. There is a heating module 1092 at the bottom of the simulator module 109 to achieve constant-temperature heating of the internal space of the simulator module 109. An artificial sweat gland module 1093 is installed at the top of the simulator module 109. The artificial sweat gland module 1093 is composed of a water pipe fixing bracket and a simulator water pipe 1094. The simulator water pipe 1094 is fixed on the water pipe fixing bracket in a disk-shaped or serpentine manner. Micro-nozzles are distributed in an array at a certain distance at the top of the simulator water pipe 1094 for the function of the artificial sweat gland to pump out sweat. The middle cavity of the simulator module 109 is filled with agar or solid hydrogel material to maintain the temperature and humidity environment in the cavity of the simulator module 109. An installation interface for a reference electrode 1097 is provided on the left side wall of the simulator module 109 to introduce the simulated physiological signal generated by the high-precision control module 2 into the simulator module 109. The reference electrode uses an Ag / AgCl electrode. A simulator water pipe interface 1096 is provided on the right side of the artificial sweat gland module 1093 to introduce the test solution in the water supply system. A temperature and humidity sensor 1095 is distributed in the middle cavity of the simulator module 109.

[0040] It should be noted that in this embodiment, the above heating module 1092 uses an array heating wire device to achieve the heating function, and through the PID algorithm in the high-precision control module 2, the constant-temperature control of the heating module 1092 is realized.

[0041] As Figure 4 shown, micro-nozzles are distributed in an array at the top of the simulator water pipe 1094. The nozzles correspond to the microporous interface end face of the moisture-conducting layer 1083, and the upward transmission of the test liquid is realized through the peristaltic pump 5.

[0042] In this embodiment, the above skin microenvironment chamber 102 is installed on the bottom plate 110. A motion bracket 101 is installed at the upper end of the skin microenvironment chamber 102 as the installation base of the motion module. Airflow heating devices 111 are respectively installed at positions on the left and right sides of the skin microenvironment chamber 102 that are at the same height as the skin simulator body. The airflow heating devices 111 can generate heated airflows to form a gas flow field with adjustable parameters on the surface of the skin module 108. When a unidirectional gas flow field is required for the test, only one of the airflow heating devices 111 on one side of the skin microenvironment chamber 102 is opened. When an opposing gas flow field is required for the test, the airflow heating devices 111 on both sides of the skin microenvironment chamber 102 are opened simultaneously. The front panel of the skin microenvironment chamber 102 is made of transparent acrylic material, and the test changes inside the skin microenvironment chamber 102 can be observed after the lid is closed. A sealing strip is installed at the opening and closing interface of the skin microenvironment chamber 102 to achieve the airtight state after the skin microenvironment chamber 102 is closed.

[0043] In this embodiment, the above-mentioned high-precision control module 2 includes a motion control module of the motion module, a control module of the temperature, humidity and air flow heating device 111, a signal acquisition module for temperature, humidity and gas flow rate, a physiological electrical signal generating device, and a high-precision signal acquisition device; the motion control module of the motion module is connected to the motion module in the skin microenvironment box 102, and is used to control the high-precision three-dimensional motion of the motion module on the surface of the skin module 108; the control module of the temperature, humidity and air flow heating device 111 is used to control the heating module 1092, the air flow heating device 111 and the water supply system installed in the skin microenvironment box 102 and the skin simulator body, so as to realize the adaptive adjustment of the above-mentioned temperature, humidity and air flow heating device 111; the signal acquisition module for temperature, humidity and gas flow rate is used to collect the parameter signals of the temperature, humidity and gas flow rate sensors 1085 installed in the skin microenvironment box 102 and the skin simulator body; the physiological electrical signal generating device is connected to the reference electrode 1097, and is used to simulate human physiological electrical signals in the skin simulator body; the high-precision signal acquisition device is installed on the motion module and is used to test the signal acquisition performance of different devices.

[0044] It should be noted that in this embodiment, the physiological electrical signal generating device can generate electroencephalogram, electrocardiogram and electromyogram signals, and the signal amplitude range is between 1 μV and 4 mV, and the frequency range is within 0.05 - 100 Hz.

[0045] It should be noted that in this embodiment, the control modules of the temperature, humidity and air flow heating device 111 all realize the adaptive adjustment of corresponding parameters by means of the fuzzy algorithm combined with the PID algorithm.

[0046] In this embodiment, the above-mentioned control system 3 is installed on a computer device and is used to realize data communication and drive control of the high-precision control module 2; the control system 3 has the functions of real-time curve display and analysis of temperature, humidity and gas flow rate signals.

[0047] In this embodiment, the above-mentioned water supply system includes a constant temperature water storage tank 7, a high-precision peristaltic pump 5, a balance 9, and a housing 4; the constant temperature water storage tank 7 is installed on the balance 9, and an installation frame 6 is installed on the top of the constant temperature water storage tank 7 for installing the high-precision peristaltic pump 5; the high-precision peristaltic pump 5 is installed on the installation frame 6, and the water inlet of the high-precision peristaltic pump 5 is vertically inserted into the upper opening of the constant temperature water storage tank 7 to avoid contact with the outer wall of the constant temperature water storage tank 7. The water outlet of the high-precision peristaltic pump 5 is connected to the simulator water pipe interface 1096 on the right side of the sweat gland simulation module 1093 in the skin simulator body to continuously supply test liquid to the sweat gland simulation module 1093 and maintain the humidity environment in the microenvironment simulator 1; the balance 9 is installed at the bottom of the housing 4, and the constant temperature water storage tank 7 is installed on the balance 9. The balance 9 records the weight change of the constant temperature water storage tank 7 in real time and transmits the real-time data to the control system 3.

[0048] In this embodiment, the above-mentioned high-precision peristaltic pump 5 is connected to the high-precision control module 2, and according to the control instructions in the high-precision control module 2, the delivery volume of the test liquid is adjusted in real time to achieve adaptive adjustment control of the water supply rate and water volume.

[0049] Those skilled in the art will readily conceive of other embodiments of the present invention after considering the specification and practicing the invention disclosed herein. This application is intended to cover any variations, uses, or adaptations of the present invention, which follow the general principles of the present invention and include known common knowledge or conventional technical means in the technical field not disclosed in this disclosure. The specification and embodiments are only regarded as exemplary, and the true scope and spirit of the present invention are pointed out by the following claims.

[0050] It should be understood that the present invention is not limited to the exact structures described above and shown in the drawings, and various modifications and changes can be made without departing from its scope. The scope of the present invention is only limited by the appended claims.

Claims

1. A skin microenvironment simulator, characterized in that, The skin microenvironment simulator is composed of a microenvironment simulator, a high-precision control module, a control system, and a water supply system; The microenvironment simulator is installed on the bottom plate. The high-precision control module and the control system are both electrically connected to the microenvironment simulator. The water supply system is connected to the microenvironment simulator through a water pipe, used to construct the temperature field, humidity field, and air flow field of the skin microenvironment, simulate the microenvironment of skin surface heat and humidity and air flow, and control the state adjustment of the skin from dry to different humidities and from wet to different drynesses; The high-precision control module is installed on the left side of the microenvironment simulator, connected to the microenvironment simulator and the water supply system, realizes the precise control of the driving device in the microenvironment simulator, the precise acquisition of the sensing device, and the adaptive adjustment of temperature, humidity, and wind speed. At the same time, it is connected and communicates with the control system; The control system is installed on the computer device, connected and communicates with the high-precision control module, and realizes the data acquisition and drive control of the high-precision control module; The water supply system is installed on the right side of the microenvironment controller, connected to the microenvironment simulator through a water pipe, realizes the transportation of the test liquid for the microenvironment simulator, and is electrically connected to the high-precision control module to realize the adaptive adjustment control of the water supply rate and water volume.

2. The skin microenvironment simulator according to claim 1, wherein The microenvironment simulator includes a skin simulator body, a motion module, and a skin microenvironment box; among them, the skin simulator body is installed on the bottom plate, and the skin simulator body is used to construct a skin heat and humidity microenvironment, with the function of adjusting the skin temperature from 20 to 40 °C and the relative humidity (RH) from 0 to 100%; the base of the motion module is installed on the motion bracket of the skin microenvironment box, and the motion mechanism is installed on the upper part of the skin simulator body inside the skin microenvironment box. Through the motion control of the motion mechanism, the three-dimensional space motion of the device clamping device on the surface of the skin simulator body can be realized; the skin microenvironment box has the function of opening and closing up and down. When opened, the installation and debugging of the skin simulator body and the motion module can be realized. When closed, a closed space including the skin simulator body and the motion module can be constructed. The skin microenvironment box also has the function of adjusting the internal environment temperature, humidity, and the wind speed on the surface of the skin simulator body.

3. The skin microenvironment simulator according to claim 2, wherein The skin simulator body includes a skin module and a simulator module. Among them, the skin module is fixed on the top of the simulator module. The skin module has the functions of moisture permeability and heat conduction. The simulator module realizes the surface humidity and temperature environment of the human skin on the surface of the skin module. The skin module can be quickly disassembled and replaced according to different environmental requirements. The skin module includes a simulated skin rough layer, a unidirectional moisture conduction layer, and a moisture conduction layer. The simulated skin rough layer is installed on the top of the unidirectional moisture conduction layer, and the unidirectional moisture conduction layer is installed on the top of the moisture conduction layer. The simulated skin rough layer is used to simulate the rough structure of the human skin epidermis. The simulated skin rough layer has the characteristics of moisture permeability and heat conduction, and at the same time, the simulated skin rough layer can realize pressure perception. The unidirectional moisture conduction layer has a unidirectional moisture conduction structure, which can realize the unidirectional liquid transfer from the moisture conduction layer to the simulated skin rough layer, but cannot realize the liquid transfer from the simulated skin rough layer to the moisture conduction layer. The moisture conduction layer has a microporous structure, which is used to control the transmission of the simulated skin sweat volume. The above-mentioned simulated skin rough layer, unidirectional moisture conduction layer, and moisture conduction layer can all be replaced with different sizes according to the required environment.

4. The skin microenvironment simulator according to claim 3, characterized in that, The simulated skin rough layer has the function of pressure perception and can sense the pressure fluctuation of the object on the surface of the simulated skin rough layer. Humidity sensors and temperature sensors are distributed in an array between the simulated skin rough layer and the unidirectional moisture conduction layer, which are used to obtain the hot and humid environment parameters of the skin module and are used for the adaptive regulation of the simulator temperature and humidity parameters by the high-precision control module.

5. The skin microenvironment simulator according to claim 3, characterized in that, The simulator module is installed in the skin microenvironment box. The upper end face of the simulator module is closely joined with the lower end face of the skin module. The simulator module has the functions of internal heating, humidification, and transmitting physiological electrical signals of the simulator. The bottom of the simulator module has a heating module to realize the constant temperature heating of the internal space of the simulator. The top of the simulator module is equipped with an artificial sweat gland module, which is composed of a water pipe fixing frame and a simulator water pipe. The simulator water pipe is fixed on the water pipe fixing frame in a disc-shaped or snake-shaped manner. Micro-outlets are distributed in an array at a certain distance on the top of the simulator water pipe, which is used for the function of the artificial sweat gland to pump out sweat. The middle cavity of the simulator module is filled with agar or solid hydrogel material to maintain the temperature and humidity environment in the cavity of the simulator module. A reference electrode installation interface is provided on the left side wall of the simulator module, which is used to introduce the simulated physiological signal generated by the high-precision control module into the simulator module. A simulator water pipe interface is provided on the right side of the artificial sweat gland module, which is used to introduce the test solution in the water supply system. Humidity and temperature sensors are distributed in the middle cavity of the simulator module.

6. The skin microenvironment simulator according to claim 2, wherein The motion module has a two-dimensional motion slide rail, a high-precision vertical push rod, a pressure acquisition module, a device clamping mechanism, and a temperature measurement device; the two-dimensional motion slide rail is installed on the base of the motion module and can realize the free movement function in the X and Y axis directions; the base of the high-precision vertical push rod is installed on the mounting seat of the two-dimensional motion slide rail, and the pressure acquisition module is installed on the top of the high-precision vertical push rod to realize the motion adjustment of the motion module in the vertical direction; the device clamping mechanism is connected to the pressure acquisition module to collect the change in the contact pressure between the device and the skin module; the temperature measurement device is installed at the far end of the two-dimensional motion slide rail of the skin microenvironment chamber, the temperature measurement device is vertically corresponding to the surface of the skin module, and the temperature measurement device detects the surface temperature change of the simulated skin rough layer in the skin module from the top end.

7. The skin microenvironment simulator according to claim 2, characterized in that, The skin microenvironment chamber is installed on the bottom plate, and a motion support is installed at the upper end of the skin microenvironment chamber as the mounting base of the motion module; air flow heating devices are respectively installed at the positions on the left and right sides of the skin microenvironment chamber at the same height as the skin simulator body to form an adjustable micro-flow field on the surface of the skin module; the front panel of the skin microenvironment chamber is made of transparent material, and the internal test changes of the skin microenvironment chamber can be observed after the lid is closed.

8. The skin microenvironment simulator according to claim 1, wherein The high-precision control module includes a motion control module of the motion module, a control module for the temperature and humidity and the air flow heating device, a signal acquisition module for the temperature and humidity and the gas flow rate, a physiological electrical signal generating device, and a high-precision signal acquisition device; the motion control module of the motion module is connected to the motion module in the skin microenvironment chamber to control the high-precision three-dimensional motion of the motion module on the surface of the skin module; the control module for the temperature and humidity and the air flow heating device is used to control the heating module, the air flow heating device, and the water supply system installed in the skin microenvironment chamber and the skin simulator body to realize the adaptive adjustment of the above temperature and humidity and the air flow heating device; the signal acquisition module for the temperature and humidity and the gas flow rate is used to collect the parameter signals of the temperature and humidity sensors and the gas flow rate sensors installed in the skin microenvironment chamber and the skin simulator body; the physiological electrical signal generating device is connected to the reference electrode to simulate human physiological electrical signals in the skin simulator body; the high-precision signal acquisition device is installed on the motion module to test the signal acquisition performance of different devices.

9. The skin microenvironment simulator according to claim 1, characterized in that, The control system is installed on a computer device to realize data communication and drive control of the high-precision control module; the control system can realize the real-time curve display and parameter analysis of the temperature and humidity and the gas flow rate signals.

10. The skin microenvironment simulator according to claim 1, wherein The water supply system includes a constant temperature water storage tank, a high-precision peristaltic pump, a balance, and a housing; the constant temperature water storage tank is installed on the balance, and an installation frame is installed on the top of the constant temperature water storage tank for installing the high-precision peristaltic pump; the high-precision peristaltic pump is installed on the installation frame, and the water inlet of the high-precision peristaltic pump is vertically inserted into the upper opening of the constant temperature water storage tank to avoid contacting the outer wall of the constant temperature water storage tank. The water outlet of the high-precision peristaltic pump is connected to the simulator water pipe interface on the right side of the sweat gland simulation module in the skin simulator body to continuously supply test liquid to the sweat gland simulation module and maintain the humidity environment in the skin microenvironment simulator; the balance is installed at the bottom of the housing, and the constant temperature water storage tank is installed on the balance. The balance records the weight change of the constant temperature water storage tank in real time and transmits the real-time data to the control system; the high-precision peristaltic pump is connected to the high-precision control module, and according to the control instructions in the high-precision control module, the regulation of the test liquid delivery volume is carried out in real time to realize the adaptive regulation control of the water supply rate and water volume.

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