Diabetes treatment medicine based on pancreas elimination and preparation method thereof

Abstract

The invention discloses a pancreatic elimination-based diabetes treatment medicine and a preparation method thereof, the pancreatic elimination-based diabetes treatment medicine comprises the following components by weight: 10-18g of radix scrophulariae, and the pancreatic elimination-based diabetes treatment medicine has the beneficial effects that the medicine is elaborately compatible with various Chinese herbal medicine components, such as radix scrophulariae, ramuli euonymi and semen plantaginis, and the components have the effects of clearing heat, detoxifying, promoting diuresis and reducing blood sugar in the traditional Chinese medicine theory; through the comprehensive action of the components, the body function of a diabetic patient can be comprehensively conditioned, insulin resistance is effectively improved, and the blood sugar level is reduced, so that effective treatment on diabetes is realized; the components such as peach kernels, dogwood and coix seeds in the medicine are compatible according to the proportion of 1: 1: 1 and can achieve a synergistic effect, strengthen the pancreas islet function and promote secretion and utilization of insulin, meanwhile, by adding blood sugar regulating materials such as schisandra chinensis and dendrobium nobile, the blood sugar level is further regulated, the blood sugar of a patient is kept within a relatively stable range, and the blood sugar content of the patient is reduced. And adverse effects caused by blood sugar fluctuation are reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of drugs for treating diabetes, and particularly to a diabetes treatment drug based on pancreas elimination and its preparation method. Background Art

[0002] Diabetes is a chronic disease marked by hyperglycemia, caused by absolute or relative insulin deficiency and utilization disorders. Genetic and environmental factors jointly lead to the occurrence of diabetes. Specifically: Genetic factors: Diabetes has an obvious genetic tendency, especially type 1 diabetes, whose onset is closely related to genetic factors. If there is a family history of diabetes, the risk of an individual developing diabetes may increase; Environmental factors: Environmental factors also play an important role in the onset of diabetes, including poor lifestyle, overnutrition, lack of physical activity, etc. These factors may all lead to insufficient insulin secretion or insulin resistance, thus triggering diabetes. The symptoms of diabetes mainly manifest as "three more and one less", namely excessive drinking, excessive urination, excessive eating, and weight loss. In addition, patients may also experience symptoms such as blurred vision, skin infections, dizziness, fatigue, and weakness. The treatment principles of diabetes mainly include early diagnosis, early treatment, and comprehensive treatment. Treatment methods include diet therapy, exercise therapy, drug therapy, blood glucose monitoring, and diabetes education, etc. As a global metabolic disease, the pathogenesis of diabetes is complex, involving multiple aspects such as insufficient insulin secretion and insulin resistance. In traditional Chinese medicine theory, diabetes is often regarded as the category of "consumptive thirst syndrome", which is closely related to the dysfunction of internal organs such as the spleen, lung, and kidney. In recent years, with the in-depth study of diabetes, the concept of pancreas elimination has gradually attracted attention and become an important direction for exploring new methods for treating diabetes; The concept of pancreas elimination emphasizes adjusting pancreatic function to restore the normal secretion and utilization of insulin, thereby achieving the purpose of treating diabetes. This concept not only conforms to the overall concept and syndrome differentiation and treatment principles of traditional Chinese medicine but also coincides with the modern medical understanding of the pathogenesis of diabetes; In the traditional treatment of diabetes, drug therapy occupies an important position. However, existing diabetes treatment drugs, such as insulin, sulfonylureas, biguanides, etc., although they can control blood glucose levels to a certain extent, often have many side effects during long-term application, such as hypoglycemia, weight gain, gastrointestinal reactions, etc., and their effects on improving islet β-cell function and reducing insulin resistance are limited, making it difficult to meet the comprehensive treatment needs of diabetes patients. Summary of the Invention

[0003] The object of the present invention is to provide a diabetes treatment drug based on pancreas elimination and its preparation method, so as to solve the problems in the above-mentioned background technology that although existing diabetes treatment drugs, such as insulin, sulfonylureas, biguanides, etc., can control blood sugar levels to a certain extent, long-term application is often accompanied by many side effects, such as hypoglycemia, weight gain, gastrointestinal reactions, etc., and their effects on improving pancreatic islet β-cell function and reducing insulin resistance are limited, making it difficult to meet the comprehensive treatment needs of diabetic patients.

[0004] To achieve the above object, the present invention provides the following technical solution: A diabetes treatment drug based on pancreas elimination, and the components are in the following weight ratio: Scrophulariae Radix: 10 - 18 g, Euonymi Alati Radix: 15 - 20 g, Plantaginis Semen: 10 - 14 g, Raphani Semen: 10 - 15 g, Pteris Multifida Poir.: 8 - 12 g, Glycyrrhizae Radix Preparata: 6 - 10 g, Carthami Flos: 12 - 15 g, heat-clearing medicine: 4 - 8 g, Ophiopogonis Radix: 5 - 8 g, Armeniacae Semen Amarum: 2 - 5 g, Schisandrae Chinensis Fructus: 2 - 6 g, immune agent: 10 - 14 g, Persicae Semen: 5 - 10 g, Litchi Semen: 2 - 4 g, Corni Fructus: 5 - 10 g, Coicis Semen: 5 - 10 g, Ziziphi Spinosae Semen: 4 - 9 g, Glycyrrhizae Radix: 4 - 6 g, pancreas elimination adjuvant: 1 - 10 g, qi-tonifying and yin-nourishing drug: 2 - 8 g, blood sugar regulator: 2 - 12 g, Ephedrae Herba: 1 - 4 g.

[0005] Preferably, the ratio of Persicae Semen, Corni Fructus, and Coicis Semen is 1:1:1.

[0006] Preferably, the pancreas elimination adjuvant is one or a mixture of several of Curcumae Radix, Artemisiae Scopariae Herba, and Scutellariae Radix.

[0007] Preferably, the qi-tonifying and yin-nourishing drug is a mixture of Astragali Radix, Dioscoreae Rhizoma, and Lycii Fructus, and the ratio of Astragali Radix, Dioscoreae Rhizoma, and Lycii Fructus is 1:1:2.

[0008] Preferably, the blood sugar regulator is one of Schisandrae Chinensis Fructus and Dendrobii Caulis.

[0009] Preferably, Scrophulariae Radix, Euonymi Alati Radix, and heat-clearing medicine need to be first pulverized and soaked.

[0010] Preferably, the heat-clearing medicine is Puerariae Lobatae Radix, and the immune agent is Trichosanthis Radix.

[0011] A preparation method of a diabetes treatment drug based on pancreas elimination, comprising the following steps:

[0012] S1. Weigh Scrophulariae Radix, Euonymi Alati Radix, and heat-clearing medicine, pulverize them, soak the pulverized materials for 1 - 3 h with water, then add 5 - 8 times of water for decoction, the decoction time is 1 - 1.5 h, filter with five-layer gauze after decoction, decoct three times, and mix the filtrates obtained from the three decoctions to obtain the first liquid medicine;

[0013] S2. Weigh Plantain Seed, Radish Seed, Pteris multifida Poir., Prepared Licorice Root, and Ophiopogon japonicus, wash them, then perform processing, and obtain the second medicinal liquid after decocting;

[0014] S3. Weigh Schisandra chinensis, immune material, Litchi Seed, and Macrocarpium officinale, after cleaning and drying pretreatment, mix them together to form an auxiliary medicinal material mixture;

[0015] S4. Mix the first medicinal liquid and the second medicinal liquid at room temperature, then add the auxiliary medicinal material mixture into the first medicinal liquid and the second medicinal liquid for mixing, and heat the mixed medicinal liquid to 40 - 65 °C to obtain a mixed liquid;

[0016] S5. Weigh Safflower, Apricot Kernel, Peach Kernel, and Ziziphus jujuba seed. After decocting Apricot Kernel, Peach Kernel, and Ziziphus jujuba seed for 1 - 2 h, add Safflower and continue to decoct for 10 - 20 min, then add the mixed liquid and continue to decoct for 5 - 10 min, and mix evenly to obtain the third medicinal liquid;

[0017] S6. Weigh Coix lacryma - jobi L. and anti - pancreatic auxiliary materials, dry them in an oven at 60 - 80 °C for 1 - 2 h, then crush them, pass through a 60 - 90 - mesh sieve, and mix to obtain a crushed material;

[0018] S7. Weigh Licorice Root and blood - sugar regulating material, crush them, and make fine medicinal powder through a stainless - steel sieve;

[0019] S8. Weigh the drugs for supplementing qi and nourishing yin and Ephedra, soak them and then decoct them, and obtain an auxiliary medicinal liquid after filtering the medicinal residues;

[0020] S9. Mix the third medicinal liquid and the auxiliary medicinal liquid, pour in the crushed material, decoct for 20 - 40 min, and add the fine medicinal powder to continue decocting when the heating time reaches 10 - 20 min;

[0021] S10. After decocting is completed, filter out the medicinal residues to obtain the medicinal liquid;

[0022] S11. Add a conventional amount of compressible starch, granulate, tableting, and coat with fruit - vitamin film to obtain a diabetes treatment drug based on anti - pancreas.

[0023] Preferably, the step of weighing Plantain Seed, Radish Seed, Pteris multifida Poir., Prepared Licorice Root, and Ophiopogon japonicus in S2, washing them, then performing processing, and obtaining the second medicinal liquid after decocting specifically includes the following steps:

[0024] S21. Weigh Plantain Seed, Radish Seed, Pteris multifida Poir., Prepared Licorice Root, and Ophiopogon japonicus, wash Plantain Seed, Radish Seed, Pteris multifida Poir., and Ophiopogon japonicus, and then perform processing;

[0025] S22. After processing, add Prepared Licorice Root and soak them together, and put the soaked medicinal materials into a decocting pot;

[0026] S23. Then add an appropriate amount of clear water and decoct, constantly stirring to ensure uniform heating of the medicinal materials. After decocting for 2 - 3 hours, obtain the second medicinal liquid.

[0027] Preferably, the steps for weighing the qi - tonifying and yin - nourishing drugs and ephedra, soaking them and then decocting, and filtering the medicinal residues to obtain the auxiliary medicinal liquid in S8 are as follows:

[0028] S81. Weigh the qi - tonifying and yin - nourishing drugs and ephedra, and soak the qi - tonifying and yin - nourishing drugs and ephedra together for 10 - 20 minutes.

[0029] S82. After soaking, decoct. During the decocting process, first use high heat to boil the medicinal liquid.

[0030] S83. After boiling, turn to low heat and continue decocting for 5 - 10 minutes, then filter out the medicinal residues to obtain the auxiliary medicinal liquid.

[0031] Compared with the prior art, the beneficial effects of the present invention are as follows: This drug is carefully formulated with a variety of Chinese herbal medicine components, such as scrophularia, winged euonymus, plantain seed. These components have the effects of clearing heat, detoxifying, promoting diuresis, and reducing blood sugar in traditional Chinese medicine theory. Their combined effects can comprehensively regulate the body functions of diabetic patients, effectively improve insulin resistance, and reduce blood sugar levels, thereby achieving effective treatment of diabetes. The components such as peach kernel, cornel, and coix seed in the drug are formulated in a ratio of 1:1:1, which can act synergistically to strengthen the islet function, promote the secretion and utilization of insulin. At the same time, by adding blood sugar regulators such as schizandra and dendrobium, the blood sugar level is further regulated, enabling the patient's blood sugar to be maintained within a relatively stable range, reducing the adverse effects caused by blood sugar fluctuations. Through targeted pancreas elimination, it effectively promotes the recovery and protection of islet function, bringing new treatment hopes and a better quality of life to diabetic patients. Detailed implementation mode

[0032] The present invention provides a technical solution: A diabetes treatment drug based on pancreas elimination, and the components are in the following weight composition: Scrophularia: 10 - 18g, Winged Euonymus: 15 - 20g, Plantain Seed: 10 - 14g, Radish Seed: 10 - 15g, Pteris multifida: 8 - 12g, Prepared Licorice Root: 6 - 10g, Safflower: 12 - 15g, Heat - clearing Medicine: 4 - 8g, Ophiopogon japonicus: 5 - 8g, Apricot Kernel: 2 - 5g, Schizandra: 2 - 6g, Immune Agent: 10 - 14g, Peach Kernel: 5 - 10g, Litchi Seed: 2 - 4g, Cornel: 5 - 10g, Coix Seed: 5 - 10g, Ziziphus seed: 4 - 9g, Licorice: 4 - 6g, Pancreas - eliminating Auxiliary Material: 1 - 10g, Qi - tonifying and Yin - nourishing Drug: 2 - 8g, Blood Sugar Regulator: 2 - 12g, Ephedra: 1 - 4g.

[0033] Among them, the ratio of peach kernels, cornel fruits, and coix seeds is 1:1:1. The peach kernels, cornel fruits, and coix seeds in specific ratios help to enhance certain curative effects of the medicine, such as improving insulin sensitivity or regulating blood sugar levels.

[0034] Among them, the pancreas-detoxifying adjuvant is one or several mixtures of curcuma aromatica, artemisia capillaris, and scutellaria baicalensis. Using one or several mixtures of curcuma aromatica, artemisia capillaris, and scutellaria baicalensis as the pancreas-detoxifying adjuvant helps to enhance the anti-inflammatory, blood sugar-lowering, or liver-protecting effects of the medicine, thereby improving the overall health of diabetic patients.

[0035] Among them, the qi-tonifying and yin-nourishing medicine is a mixture of astragalus membranaceus, Chinese yam, and wolfberry fruits. The ratio of astragalus membranaceus, Chinese yam, and wolfberry fruits is 1:1:2. The mixture of astragalus membranaceus, Chinese yam, and wolfberry fruits in a specific ratio helps to enhance the body's immunity, improve the qi deficiency and yin deficiency symptoms of diabetic patients, and further promote the recovery of the disease.

[0036] Among them, the blood sugar regulator is one of schizandra chinensis and dendrobium officinale. Using schizandra chinensis or dendrobium officinale as the blood sugar regulator helps to regulate the blood sugar level of diabetic patients, reduce blood sugar fluctuations, and lower the risk of complications.

[0037] Among them, scrophularia ningpoensis, winged euonymus, and heat-clearing medicine need to be first pulverized and soaked. First pulverizing and soaking scrophularia ningpoensis, winged euonymus, and heat-clearing medicine helps to improve the extraction efficiency and bioavailability of the medicine, thereby enhancing the therapeutic effect.

[0038] Among them, the heat-clearing medicine is pueraria lobata, and the immune adjuvant is trichosanthes kirilowii maximowicz. It is clear that the heat-clearing medicine is pueraria lobata and the immune adjuvant is trichosanthes kirilowii maximowicz. These two medicines may have the effects of clearing heat and detoxifying, and enhancing immunity, which helps to improve the inflammatory and immune states of diabetic patients.

[0039] A preparation method of a diabetes treatment medicine based on pancreas detoxification, comprising the following steps:

[0040] S1. Weigh scrophularia ningpoensis, winged euonymus, and heat-clearing medicine, pulverize them, soak them after pulverization, soak them in water for 1 - 3 h, then add 5 - 8 times of water for decoction, the decoction time is 1 - 1.5 h, filter with five-layer gauze after decoction, decoct three times, and mix the filtrates after three times of decoction and filtration to obtain the first liquid medicine;

[0041] S2. Weigh plantain seeds, radish seeds, phoenix-tail grass, roasted licorice root, and ophiopogon japonicus, wash them and then perform processing by roasting, and obtain the second liquid medicine after decoction;

[0042] S3. Weigh schizandra chinensis, immune adjuvant, litchi seed, and cornel fruit, after cleaning and drying pretreatment, mix them together to form an auxiliary medicinal material mixture;

[0043] S4. Mix the first liquid medicine and the second liquid medicine at room temperature, then add the auxiliary medicinal material mixture into the first and second liquid medicines for mixing, and heat the mixed liquid medicine to 40 - 65 °C to obtain a mixed solution;

[0044] S5. Weigh safflower, almonds, peach kernels, and Chinese date seeds. After decocting almonds, peach kernels, and Chinese date seeds for 1 - 2 h, add safflower and continue to decoct for 10 - 20 min, then add the mixed solution and continue to decoct for 5 - 10 min. After mixing evenly, obtain the third liquid medicine;

[0045] S6. Weigh coix seeds and anti - pancreatic auxiliary materials, dry them in an oven at 60 - 80 °C for 1 - 2 h, then crush them, pass through a 60 - 90 - mesh sieve, and mix to obtain a crushed material;

[0046] S7. Weigh licorice and blood sugar regulating materials, crush the licorice and blood sugar regulating materials, and make fine medicinal powder through a stainless - steel sieve;

[0047] S8. Weigh qi - tonifying and yin - nourishing drugs and ephedra, soak them and then decoct them, and filter the medicinal residues to obtain an auxiliary liquid medicine;

[0048] S9. Mix the third liquid medicine and the auxiliary liquid medicine, pour in the crushed material, decoct for 20 - 40 min, and add the fine medicinal powder to continue decocting when the heating time reaches 10 - 20 min;

[0049] S10. After the decocting is completed, filter out the medicinal residues to obtain the liquid medicine;

[0050] S11. Add a conventional amount of compressible starch, granulate, tableting, and coat with fruit - vitamin film to obtain a diabetes treatment drug based on anti - pancreatic.

[0051] Among them, the specific steps of weighing plantain seeds, radish seeds, phoenix - tail grass, roasted licorice, and ophiopogon japonicus in S2, washing them and then performing processing, and obtaining the second liquid medicine after decocting are as follows:

[0052] S21. Weigh plantain seeds, radish seeds, phoenix - tail grass, roasted licorice, and ophiopogon japonicus, wash plantain seeds, radish seeds, phoenix - tail grass, and ophiopogon japonicus, and then perform processing;

[0053] S22. After processing, add roasted licorice and soak them together, and put the soaked medicinal materials into a decocting pot;

[0054] S23. Then add an appropriate amount of clear water for decocting, continuously stir to ensure that the medicinal materials are evenly heated, and after decocting for 2 - 3 h, obtain the second liquid medicine.

[0055] Among them, the specific steps of weighing qi - tonifying and yin - nourishing drugs and ephedra in S8, soaking them and then decocting them, and obtaining the auxiliary liquid medicine after filtering the medicinal residues are as follows:

[0056] S81. Weigh the qi - nourishing and yin - nourishing drugs and ephedra, soak the qi - nourishing and yin - nourishing drugs and ephedra together, and the soaking time is 10 - 20 min;

[0057] S82. After soaking, conduct decoction. During the decoction process, first use high heat to boil the liquid medicine;

[0058] S83. After boiling, turn to low heat and continue to decoct for 5 - 10 min, filter out the medicinal residues to obtain the auxiliary liquid medicine.

[0059] Example 1. A diabetes treatment drug based on pancreas - elimination, the components of which are in the following weight composition: Scrophulariae Radix: 10 g, Euonymi Alati Radix: 15 g, Plantaginis Semen: 10 g, Raphani Semen: 10 g, Pteris Multifida Poir.: 8 g, Glycyrrhizae Radix Preparata: 6 g, Carthami Flos: 12 g, Puerariae Lobatae Radix: 4 g, Ophiopogonis Radix: 5 g, Armeniacae Semen Amarum: 2 g, Schisandrae Chinensis Fructus: 2 g, Trichosanthis Radix: 10 g, Persicae Semen: 5 g, Litchi Semen: 2 g, Corni Fructus: 5 g, Coicis Semen: 5 g, Ziziphi Spinosae Semen: 4 g, Glycyrrhizae Radix: 4 g, Curcumae Radix: 1 g, qi - nourishing and yin - nourishing drugs: 2 g, Schisandrae Chinensis Fructus: 2 g, Ephedra: 1 g.

[0060]

[0061] A preparation method of a diabetes treatment drug based on pancreas - elimination, characterized by including the following steps:

[0062] S1. Weigh Scrophulariae Radix, Euonymi Alati Radix and Puerariae Lobatae Radix, conduct comminution treatment, after comminution, conduct soaking treatment, soak with water for 1 h, then add 5 times the amount of water for decoction, the decoction time is 1 h, after decoction, filter with five - layer gauze, decoct three times, and mix the filtrates after the three - time decoction and filtration to obtain the first liquid medicine;

[0063] S2. Weigh Plantaginis Semen, Raphani Semen, Pteris Multifida Poir., Glycyrrhizae Radix Preparata, Ophiopogonis Radix, wash Plantaginis Semen, Raphani Semen, Pteris Multifida Poir. and Ophiopogonis Radix, then conduct processing, after processing, add Glycyrrhizae Radix Preparata and soak together, put the soaked medicinal materials into the decocting pot, then add an appropriate amount of clear water for decoction, keep stirring to ensure uniform heating of the medicinal materials, after decocting for 2 h, obtain the second liquid medicine;

[0064] S3. Weigh Schisandrae Chinensis Fructus, Trichosanthis Radix, Litchi Semen, Corni Fructus, after pre - treatment of cleaning and drying, mix them together to form an auxiliary medicinal material mixture;

[0065] S4. Mix the first liquid medicine and the second liquid medicine at room temperature, then add the auxiliary medicinal material mixture into the first liquid medicine and the second liquid medicine for mixing, heat the mixed liquid medicine to 40 °C to obtain the mixed liquid;

[0066] S5. Weigh safflower, almond, peach kernel, and Chinese date seed. After decocting almond, peach kernel, and Chinese date seed for 1 h, add safflower and continue to decoct for 10 min. Then add the mixed solution and continue to decoct for 5 min. After mixing evenly, obtain the third medicinal liquid.

[0067] S6. Weigh coix seed and turmeric. Dry them in an oven at 60 °C for 1 h, then crush them, pass through a 60-mesh sieve, and mix to obtain the crushed material.

[0068] S7. Weigh licorice and schisandra chinensis. Crush licorice and schisandra chinensis and make them into fine medicinal powder through a stainless steel sieve.

[0069] S8. Weigh the drugs for replenishing qi and nourishing yin and ephedra. Soak the drugs for replenishing qi and nourishing yin and ephedra together for 10 min. After soaking, conduct decoction. During the decoction process, first use high heat to boil the medicinal liquid, and then turn to low heat and continue to decoct for 5 min. Filter out the medicinal residues to obtain the auxiliary medicinal liquid.

[0070] S9. Mix the third medicinal liquid and the auxiliary medicinal liquid, pour into the crushed material, and decoct for 20 min. When the heating time reaches 10 min, add the fine medicinal powder and continue to decoct.

[0071] S10. After the decoction is completed, filter out the medicinal residues to obtain the medicinal liquid.

[0072] S11. Add a conventional amount of compressible starch, granulate, tableting, and coat with fruit vitamin film to obtain the diabetes treatment drug based on Xiaoyi.

[0073] Example 2. A diabetes treatment drug based on Xiaoyi, and the components are in the following weight composition: scrophularia ningpoensis: 18 g, winged euonymus: 20 g, plantain seed: 14 g, radish seed: 15 g, phoenix-tail grass: 12 g, roasted licorice: 10 g, safflower: 15 g, kudzu root: 8 g, ophiopogon japonicus: 8 g, almond: 5 g, schisandra chinensis: 6 g, trichosanthes root: 14 g, peach kernel: 10 g, litchi seed: 4 g, cornel: 10 g, coix seed: 10 g, Chinese date seed: 9 g, licorice: 6 g, turmeric: 10 g, drugs for replenishing qi and nourishing yin: 8 g, schisandra chinensis: 12 g, ephedra: 4 g.

[0074]

[0075] A preparation method of a diabetes treatment drug based on Xiaoyi, which is characterized by including the following steps:

[0076] S1. Weigh scrophularia ningpoensis, winged euonymus, and kudzu root, conduct crushing treatment, soak after crushing for 3 h with water, then add 8 times of water for decoction, the decoction time is 1.5 h, filter with five-layer gauze after decoction, decoct three times, and mix the filtrates after filtering the three decoctions to obtain the first medicinal liquid.

[0077] S2. Weigh Plantain Seed, Radish Seed, Pteris multifida Poir., Prepared Licorice Root, and Ophiopogon japonicus. Wash Plantain Seed, Radish Seed, Pteris multifida Poir., and Ophiopogon japonicus, and then perform processing. After processing, add Prepared Licorice Root and soak them together. Put the soaked medicinal materials into a decocting pot, then add an appropriate amount of water for decocting, and continuously stir to ensure uniform heating of the medicinal materials. After decocting for 3 hours, obtain the second medicinal liquid.

[0078] S3. Weigh Schisandra chinensis, Trichosanthes kirilowii Maxim., Litchi Seed, and Macrocarpium officinale Sieb. et Zucc. After cleaning and drying pretreatment, mix them together to form a mixture of auxiliary medicinal materials.

[0079] S4. Mix the first medicinal liquid and the second medicinal liquid at room temperature, then add the mixture of auxiliary medicinal materials into the first and second medicinal liquids for mixing. Heat the mixed medicinal liquid to 65 °C to obtain a mixed liquid.

[0080] S5. Weigh Safflower, Apricot Kernel, Peach Kernel, and Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow. After decocting Apricot Kernel, Peach Kernel, and Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow for 2 hours, add Safflower and continue decocting for 20 minutes, then add the mixed liquid and continue decocting for 10 minutes. After mixing evenly, obtain the third medicinal liquid.

[0081] S6. Weigh Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf and Curcuma aromatica Salisb. Dry them in an oven at 80 °C for 2 hours, then crush them and pass through a 90-mesh sieve. After mixing, obtain a crushed material.

[0082] S7. Weigh Licorice Root and Schisandra chinensis, crush them, and make fine medicinal powder through a stainless steel sieve.

[0083] S8. Weigh the drugs for supplementing qi and nourishing yin and Ephedra, soak the drugs for supplementing qi and nourishing yin and Ephedra together for 20 minutes, and then perform decocting. During the decocting process, first use high heat to boil the medicinal liquid, and after boiling, turn to low heat and continue decocting for 10 minutes. Filter out the medicinal residues to obtain an auxiliary medicinal liquid.

[0084] S9. Mix the third medicinal liquid and the auxiliary medicinal liquid, pour in the crushed material, and decoct for 40 minutes. When the heating time reaches 20 minutes, add the fine medicinal powder and continue decocting.

[0085] S10. After completion of decocting, filter out the medicinal residues to obtain a medicinal liquid.

[0086] S11. Add a conventional amount of compressible starch, granulate, tableting, and coat with fruit vitamin film to obtain a diabetes treatment drug based on Xiaoyi.

[0087] Example 3

[0088] A diabetes treatment drug based on pancreas elimination, and the components are in the following weight composition: Scrophulariae Radix: 15g, Ramulus Euonymi: 18g, Plantaginis Semen: 13g, Raphani Semen: 12g, Pteris Multifida Poir: 10g, Glycyrrhizae Radix Preparata: 8g, Carthami Flos: 14g, Puerariae Lobatae Radix: 6g, Ophiopogonis Radix: 6g, Armeniacae Semen Amarum: 3g, Schisandrae Chinensis Fructus: 4g, Trichosanthis Radix: 12g, Persicae Semen: 8g, Litchi Semen: 3g, Corni Fructus: 8g, Coicis Semen: 8g, Ziziphi Spinosae Semen: 7g, Glycyrrhizae Radix: 5g, Curcumae Radix: 5g, Qi-tonifying and Yin-nourishing drug: 5g, Schisandrae Chinensis Fructus: 8g, Ephedrae Herba: 3g.

[0089]

[0090] A preparation method of a diabetes treatment drug based on pancreas elimination, characterized by comprising the following steps:

[0091] S1. Weigh Scrophulariae Radix, Ramulus Euonymi and Puerariae Lobatae Radix, conduct comminution treatment, soak after comminution, soak with water for 2h, then add 7 times of water for decoction, the decoction time is 1.25h, filter with five-layer gauze after decoction, decoct three times, and mix the filtrates after three times of decoction and filtration to obtain the first medicinal liquid;

[0092] S2. Weigh Plantaginis Semen, Raphani Semen, Pteris Multifida Poir, Glycyrrhizae Radix Preparata, Ophiopogonis Radix, wash Plantaginis Semen, Raphani Semen, Pteris Multifida Poir, Ophiopogonis Radix, then conduct processing, add Glycyrrhizae Radix Preparata for soaking after processing, put the soaked medicinal materials into a decocting pot, then add an appropriate amount of clear water for decoction, continuously stir to ensure uniform heating of the medicinal materials, and obtain the second medicinal liquid after decocting for 2.5h;

[0093] S3. Weigh Schisandrae Chinensis Fructus, Trichosanthis Radix, Litchi Semen, Corni Fructus, after cleaning and drying pretreatment, mix them together to form an auxiliary medicinal material mixture;

[0094] S4. Mix the first medicinal liquid and the second medicinal liquid at room temperature, then add the auxiliary medicinal material mixture into the first medicinal liquid and the second medicinal liquid for mixing, and heat the mixed medicinal liquid to 50°C to obtain a mixed liquid;

[0095] S5. Weigh Carthami Flos, Armeniacae Semen Amarum, Persicae Semen, Ziziphi Spinosae Semen, decoct Armeniacae Semen Amarum, Persicae Semen, Ziziphi Spinosae Semen for 1.5h, add Carthami Flos and continue to decoct for 15min, then add the mixed liquid and continue to decoct for 7min, and obtain the third medicinal liquid after mixing evenly;

[0096] S6. Weigh Coicis Semen, Curcumae Radix, dry in an oven at 70°C for 1.5h, then comminute, pass through a 75-mesh sieve, and obtain a comminuted material after mixing;

[0097] S7. Weigh Glycyrrhizae Radix, Schisandrae Chinensis Fructus, conduct comminution treatment on Glycyrrhizae Radix, Schisandrae Chinensis Fructus, and make fine medicinal powder through a stainless steel sieve;

[0098] S8. Weigh the drugs for supplementing qi and nourishing yin and ephedra, soak the drugs for supplementing qi and nourishing yin and ephedra together for 15 minutes, and then decoct them after soaking. During the decocting process, first use high heat to boil the liquid medicine, and then turn to low heat and continue to decoct for 7 minutes. Filter out the medicinal residues to obtain the auxiliary liquid medicine;

[0099] S9. Mix the third liquid medicine and the auxiliary liquid medicine, pour in the crushed material, and decoct for 30 minutes. Add the fine medicinal powder and continue to decoct when the heating time reaches 15 minutes;

[0100] S10. After the decocting is completed, filter out the medicinal residues to obtain the liquid medicine;

[0101] S11. Add a conventional amount of compressible starch, granulate, tabletten, and coat with fruit vitamin film to obtain the diabetes treatment drug based on Xiaoyi.

[0102] In the present invention, unless otherwise clearly specified and defined, the terms "installation", "setting", "connection", "fixation", "swivel connection", etc. should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication of two components or the interaction relationship between two components. Unless otherwise clearly defined, for those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0103] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirits of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A diabetes treatment drug based on eliminating the pancreas, characterized in that, The components are in the following weight composition: Scrophulariae Radix: 10 - 18 g, Winged Euonymus Twig: 15 - 20 g, Asiatic Plantain Seed: 10 - 14 g, Radish Seed: 10 - 15 g, Chinese Brake Herb: 8 - 12 g, Honey-fried Licorice Root: 6 - 10 g, Safflower: 12 - 15 g, Heat-clearing Herbs: 4 - 8 g, Dwarf Lilyturf Tuber: 5 - 8 g, Apricot Kernel: 2 - 5 g, Schisandra Fruit: 2 - 6 g, Immunity Agent: 10 - 14 g, Peach Kernel: 5 - 10 g, Litchi Seed: 2 - 4 g, Macrocarpium Fruit: 5 - 10 g, Job's Tears: 5 - 10 g, Ziziphus Seed: 4 - 9 g, Licorice Root: 4 - 6 g, Pancreatic-digesting Adjuvant: 1 - 10 g, Qi-tonifying and Yin-nourishing Herbs: 2 - 8 g, Blood-glucose-regulating Agent: 2 - 12 g, Ephedra: 1 - 4 g.

2. The diabetes treatment drug based on pancreas elimination according to claim 1, wherein: The ratio of the Peach Kernel, Macrocarpium Fruit, and Job's Tears is 1:1:

1.

3. A diabetes treatment drug based on pancreatic digestion according to claim 2, characterized in that: The Pancreatic-digesting Adjuvant is one or a mixture of several of Curcuma aromatica Salisb., Artemisia capillaris Thunb., and Scutellaria baicalensis Georgi.

4. A diabetes treatment drug based on pancreas elimination according to claim 3, characterized in that: The Qi-tonifying and Yin-nourishing Herbs is a mixture of Astragalus membranaceus (Fisch.) Bunge, Chinese Yam Rhizome, and Chinese Wolfberry Fruit, and the ratio of Astragalus membranaceus (Fisch.) Bunge, Chinese Yam Rhizome, and Chinese Wolfberry Fruit is 1:1:

2.

5. The anti-diabetic therapeutic drug based on pancreas elimination according to claim 4, characterized in that: The Blood-glucose-regulating Agent is one of Schisandra Fruit and Dendrobium officinale Kimura et Migo.

6. The antidiabetic therapeutic drug based on pancreas elimination according to claim 5, characterized in that: The Scrophulariae Radix, Winged Euonymus Twig, and Heat-clearing Herbs need to be first pulverized and soaked.

7. The anti-diabetic therapeutic drug based on pancreas elimination according to claim 6, characterized in that: The Heat-clearing Herbs is Pueraria lobata (Willd.) Ohwi, and the Immunity Agent is Trichosanthes kirilowii Maxim.

8. The preparation method of a diabetes treatment drug based on pancreatic digestion according to any one of claims 1-7, characterized in that, It includes the following steps: S1. Weigh Scrophulariae Radix, Winged Euonymus Twig, and Heat-clearing Herbs, conduct pulverization treatment, soak after pulverization, soak in water for 1 - 3 h, then add 5 - 8 times the amount of water for decoction, the decoction time is 1 - 1.5 h, filter with five-layer gauze after decoction, decoct three times, and mix the filtrates after the three decoctions and filtrations to obtain the first decoction. S2. Weigh Asiatic Plantain Seed, Radish Seed, Chinese Brake Herb, Honey-fried Licorice Root, and Dwarf Lilyturf Tuber, wash and then conduct processing for decoction, and obtain the second decoction after decoction. S3. Weigh Schisandra Fruit, Immunity Agent, Litchi Seed, and Macrocarpium Fruit, after pre-treatment of washing and drying, mix them together to form a mixture of auxiliary medicinal materials. S4. Mix the first decoction and the second decoction at room temperature, then add the mixture of auxiliary medicinal materials into the first decoction and the second decoction for mixing, and heat the mixed decoction to 40 - 65 °C to obtain a mixed solution. S5. Weigh Safflower, Apricot Kernel, Peach Kernel, and Ziziphus Seed, decoct the Apricot Kernel, Peach Kernel, and Ziziphus Seed for 1 - 2 h, add Safflower and continue to decoct for 10 - 20 min, then add the mixed solution and continue to decoct for 5 - 10 min, and mix evenly to obtain the third decoction. S6. Weigh Job's Tears and Pancreatic-digesting Adjuvant, dry in an oven at 60 - 80 °C for 1 - 2 h, then pulverize, pass through a 60 - 90 mesh sieve, and mix to obtain a pulverized material. S7. Weigh Licorice Root and Blood-glucose-regulating Agent, conduct pulverization treatment on Licorice Root and Blood-glucose-regulating Agent, and make fine medicinal powder through a stainless steel sieve. S8. Weigh Qi-tonifying and Yin-nourishing Herbs and Ephedra, soak and then conduct decoction, and filter the medicinal residues to obtain an auxiliary decoction. S9. Mix the third decoction and the auxiliary decoction, pour into the pulverized material, decoct for 20 - 40 min, and add the fine medicinal powder to continue decocting when the heating time reaches 10 - 20 min. S10. After the decoction is completed, filter out the medicinal residues to obtain a decoction. S11. Add a conventional amount of compressible starch, granulate, tablet, and coat with a fruit vitamin film to obtain a diabetes treatment drug based on pancreatic digestion.

9. The preparation method of a diabetes treatment drug based on pancreatic digestion according to claim 8, characterized in that, Weigh the plantain seeds, radish seeds, Pteris multifida Poir., roasted licorice root, and Ophiopogon japonicus in S2. After washing, conduct processing by roasting, and obtain the second medicinal liquid after decocting, which specifically includes the following steps: S21: Weigh the plantain seeds, radish seeds, Pteris multifida Poir., roasted licorice root, and Ophiopogon japonicus. Wash the plantain seeds, radish seeds, Pteris multifida Poir., and Ophiopogon japonicus, and then conduct processing by roasting; S22: After roasting, add the roasted licorice root and soak them together. Put the soaked medicinal materials into a decocting pot; S23: Then add an appropriate amount of water for decocting, continuously stir to ensure uniform heating of the medicinal materials. After decocting for 2 - 3 hours, obtain the second medicinal liquid.

10. The preparation method of a diabetes treatment drug based on pancreas elimination according to claim 8, characterized in that, Weigh the qi - tonifying and yin - nourishing drugs and ephedra in S8. After soaking, conduct decocting, and obtain the auxiliary medicinal liquid after filtering the medicinal residues, which specifically includes the following steps: S81: Weigh the qi - tonifying and yin - nourishing drugs and ephedra. Conduct co - soaking treatment on the qi - tonifying and yin - nourishing drugs and ephedra, and the soaking time is 10 - 20 minutes; S82: After soaking, conduct decocting. During the decocting process, first use high heat to boil the medicinal liquid; S83: After boiling, turn to low heat and continue decocting for 5 - 10 minutes, filter out the medicinal residues, and obtain the auxiliary medicinal liquid.

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