Application of self-polarized polyvinylidene fluoride in preparation of scalp care product

Abstract

The invention belongs to the technical field of medical materials, and particularly relates to application of self-polarized polyvinylidene fluoride in preparation of a scalp care product. Self-polarized polyvinylidene fluoride is used for preparing the scalp care product for the first time, and when the scalp care product acts on the scalp, the self-polarized polyvinylidene fluoride material is activated by responding to the friction force between the product and the scalp, so that the self-polarized polyvinylidene fluoride material generates a large number of active species, and the scalp care effect is improved. Microorganisms causing inflammation, alopecia, dandruff and other symptoms in the scalp can be removed, the scalp problem caused by scalp micro-ecological imbalance is solved, and the scalp nursing effect is achieved. The scalp care product disclosed by the invention can be used for a long time in daily life, is safe and non-toxic, is activated by utilizing external mechanical force, is energy-saving and environment-friendly, does not damage the scalp, and can realize scalp care which is quick, efficient, low in cost, low in energy consumption, convenient to carry, safe and non-irritating. Therefore, the method has a good application prospect.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical materials, and particularly relates to the use of self-polarized polyvinylidene fluoride in the preparation of scalp care products. Background Art

[0002] Self-polarized polyvinylidene fluoride (PVDF) is prepared by subjecting the molecular chains of polyvinylidene fluoride to self-polarization through a special preparation process. Its charge is asymmetrically distributed, thus having piezoelectric properties. PVDF exhibits excellent performance in piezoelectric properties and is widely used in various application scenarios that require conversion into electrical energy, such as sound sensors, pressure sensors, etc. In addition, self-polarized polyvinylidene fluoride is also applied in the medical field. For example, the Chinese invention patent "CN202410076320.9 Self-polarized Polyvinylidene Fluoride Composite and Its Use in the Preparation of Antibacterial Products" discloses that a material containing a self-polarized polyvinylidene fluoride composite has antibacterial activity.

[0003] As a part of the human skin, the scalp has a rich microbial ecosystem, including various microorganisms such as bacteria, fungi, and mites. These microorganisms coexist with the human body under normal circumstances, forming a dynamic balance, which plays an important role in maintaining scalp health, inhibiting the over-proliferation of harmful microorganisms, participating in skin barrier function, and immune regulation. When the scalp microbial ecosystem is imbalanced due to internal and external factors (such as stress, decreased immune function, hormonal changes, drug use, bad living habits, etc.), it may cause symptoms such as inflammation, alopecia, and dandruff.

[0004] The scalp problems caused by these microorganisms usually require targeted antimicrobial treatments (such as antibacterial lotions, antifungal ointments, acaricides, etc.). In some cases, anti-inflammatory drugs, immunomodulators, or hormonal drugs may also need to be used in combination to relieve the inflammatory response and promote scalp health. However, drug treatments have problems such as toxic side effects, damage to the scalp after long-term use, easy recurrence, and inconvenient use. Therefore, developing a care product that can safely and conveniently condition the scalp microecosystem and maintain scalp health in daily life has high application value. This is also the problem to be solved by the technology in this field. Summary of the Invention

[0005] In view of the problems of the prior art, the present invention provides a self-polarized polyvinylidene fluoride composite and its use in the preparation of antibacterial products.

[0006] The use of self-polarized polyvinylidene fluoride in the preparation of scalp care products.

[0007] Preferably, the scalp care product is a comb, a shampoo brush, or a massage brush.

[0008] Preferably, the self-polarized polyvinylidene fluoride is used to prepare the teeth of a comb, the bristles of a shampoo brush, or the bristles of a massage brush.

[0009] Preferably, the scalp care product is used to remove bacteria, fungi, or parasites from the scalp.

[0010] Preferably, the scalp care product is used to improve scalp inflammation, alopecia, or dandruff.

[0011] The present invention also provides a scalp care product, which is made of self-polarized polyvinylidene fluoride as the active material and other auxiliary materials.

[0012] Preferably, the scalp care product is a comb, a shampoo brush, or a massage brush.

[0013] Preferably, the self-polarized polyvinylidene fluoride is used to prepare the teeth of a comb, the bristles of a shampoo brush, or the bristles of a massage brush.

[0014] Preferably, the scalp care product is used to remove bacteria, fungi, or parasites from the scalp.

[0015] Preferably, the scalp care product is used to improve scalp inflammation, alopecia, or dandruff.

[0016] In the present invention, the "auxiliary materials" refer to other materials necessary to form a complete scalp care product in addition to the self-polarized polyvinylidene fluoride. For example: when the scalp care product is a shampoo brush, the shampoo brush consists of a handle and bristles. The handle material of the shampoo brush can be any material with mechanical strength meeting the requirements in the prior art, and this material is the "auxiliary material"; in addition, in addition to using self-polarized polyvinylidene fluoride in the bristles, various existing polymer materials or inorganic materials can be added to provide appropriate mechanical properties, and these materials also belong to the scope of the "auxiliary materials". The "active species" include free radicals, metastable states, molecules and ions with high electron affinity, etc., and have extremely high reactivity.

[0017] The present invention provides the use of self-polarized polyvinylidene fluoride in the preparation of scalp care products, and further provides a scalp care product made therefrom. When the scalp care product of the present invention acts on the scalp, by responding to the friction between the product and the scalp, the self-polarized polyvinylidene fluoride (PVDF) material is activated to generate a large number of active species, which can remove the microorganisms in the scalp that cause symptoms such as inflammation, alopecia, and dandruff, solve the scalp problems caused by scalp microecological imbalance, and achieve the scalp care effect. The scalp care product of the present invention can be used for a long time in daily life, is safe and non-toxic, is activated by external mechanical force, energy-saving and environmentally friendly, and will not cause damage to the scalp, and can achieve fast, efficient, low-cost, low-energy consumption, portable and convenient, safe and non-irritating scalp care. Therefore, the present invention has good application prospects.

[0018] Obviously, based on the above content of the present invention, according to the common general knowledge and conventional means in the art, without departing from the above basic technical idea of the present invention, various other forms of modifications, substitutions or changes can be made.

[0019] The following is a further detailed description of the above content of the present invention through specific embodiments in the form of examples. However, this should not be construed as limiting the scope of the above subject matter of the present invention to the following examples. All technologies implemented based on the above content of the present invention belong to the scope of the present invention. Brief Description of the Drawings

[0020] Figure 1 It is a schematic structural diagram of the massage brush in Example 1.

[0021] Figure 2 It is a test of the amount of charge generated by the PVDF piezoelectric brush wire during the bending process.

[0022] Figure 3 It is the working principle of the PVDF piezoelectric brush generating reactive oxygen species (ROSs) during the bending process.

[0023] Figure 4 It is an electron paramagnetic resonance spectrogram of the hydroxyl radicals generated by the PVDF piezoelectric brush wire during the bending process over time.

[0024] Figure 5 It is an electron paramagnetic resonance spectrogram of the superoxide radicals generated by the PVDF piezoelectric brush wire during the bending process over time.

[0025] Figure 6 It is the hydrogen radicals generated by the PVDF piezoelectric brush wire during the bending process.

[0026] Figure 7 It is a side photo of the piezoelectric head comb sample in Experimental Example 2.

[0027] Figure 8 This is a photo of the testing process in Experimental Example 2.

[0028] Figure 9 This is the electron paramagnetic resonance (EPR) spectrum of the generation of reactive oxygen species (ROSs) during the friction process of the hair comb. Detailed implementation mode

[0029] In the following examples, the reagents and materials not specifically described are all commercially available products.

[0030] Example 1: A scalp care product made of self-polarized polyvinylidene fluoride

[0031] This example provides a scalp care product made of polyvinylidene fluoride. The form of this scalp care product can be any daily necessities that directly contact the scalp, such as: combs, shampoo brushes, and massage brushes.

[0032] In a preferred solution, taking the massage brush as an example, its structure is as Figure 1 shown, including a handle and bristles 1. Among them: The bristles 1 are made of polyvinylidene fluoride as a single component or as one component in a composite component. When the bristles 1 are made of a composite component, the raw materials can also include other polymer materials or inorganic materials used to adjust the mechanical properties of the bristles 1.

[0033] In another preferred solution, taking the comb as an example, a PVDF piezoelectric comb is used to assist in hair growth products. The active ingredient of this comb is PVDF piezoelectric brush filaments, and the brush handle can be made of other common materials such as plastics and woods; the arrangement of the brush filaments can be adjusted, and the ordinary brush filaments or massage balls are combined with the PVDF piezoelectric brush filaments in various ways. Before using the hair growth product, active oxygen species are generated by the PVDF piezoelectric comb to inactivate some bacteria on the scalp surface and remove some oils, etc., thereby regulating the scalp microenvironment and providing favorable conditions for the absorption of hair growth drugs and hair growth; after using the hair growth drug, the PVDF piezoelectric comb can perform mechanical force stimulation, microcurrent stimulation, and stimulation of active free radical species (reactive oxygen species and active hydrogen atoms) to assist hair regeneration. In addition, the ability of the PVDF piezoelectric comb to generate active free radicals and microcurrents, and the friction force can be adjusted by adjusting the PVDF material ratio or the arrangement of the brush filaments.

[0034] It should be particularly noted that when designing the scalp care product in this example, the polymer material polyvinylidene fluoride (PVDF) was selected from numerous piezoelectric materials. The reasons are as follows:

[0035] 1. PVDF has good processing performance and low cost;

[0036] 2. It has good ability to generate reactive oxygen species (ROSs);

[0037] 3. Have good ability to generate active hydrogen atoms ( · H).

[0038] In summary, as a daily necessity, the scalp care product of this embodiment can, when used continuously for a long time, remove the microorganisms in the scalp that cause symptoms such as inflammation, alopecia, and dandruff, significantly improve scalp problems such as inflammation, alopecia, and dandruff caused by scalp microecological imbalance, and achieve the scalp care effect.

[0039] The technical solution of the present invention will be further described through experiments below.

[0040] Experimental Example 1 Test on the Ability of PVDF Piezoelectric Brush Filaments to Generate Reactive Oxygen Species (ROSs) and Active Hydrogen Atoms (·H)

[0041] I. Experimental Method

[0042] PVDF piezoelectric brush filaments were prepared by 3D printing. Information on raw material manufacturers and product numbers: polyvinylidene fluoride powder (PVDF, HSV900, molecular weight 500,000, Arkema (Changshu) Fluorochemical Co., Ltd.).

[0043] 1. Test on the electrical signal generated during the bending process of PVDF piezoelectric brush filaments

[0044] The voltage signal of the PVDF piezoelectric brush filament material was measured by a comprehensive current-voltage performance tester (JYC3100, Xi'an Hechuang, China), where the particles were sandwiched between two pieces. Two copper tapes covered with PET films were connected to the tester. A robotic arm was used to fix the load input to activate the PVDF piezoelectric brush filament material to generate voltage output. To measure the repeatable voltage output, the PVDF piezoelectric brush filament material was sealed in a cylindrical container with two electrodes. Connected to a general tester, the voltage signal was measured in the presence and absence of an external load (10 N), as Figure 2 shown.

[0045] 2. Test on the generation of reactive oxygen species during the bending process of PVDF piezoelectric brush filaments

[0046] 0.03 g of PVDF piezoelectric brush filament material, 5 mL of deionized water, and 20 μL of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) with a concentration of 1 mo1 / L were placed in a 5-mL small beaker. The small beaker was placed on the probe of an ultrasonic therapy instrument. The power density of the ultrasonic therapy instrument was 3 W / cm 2 , the ultrasonic frequency was 1 MHz, and the ultrasonic time was as shown. An electron paramagnetic resonance spectrometer was used to detect the · OH and · O2 - generated by the PVDF piezoelectric brush filament material during the activation process, as shown in Figure 4 .Figure 5 。 Figure 4 It shows the changes in the signal peaks of hydroxyl radicals at different time points in the PVDF piezoelectric brush filament material system within 10 minutes. The signal peak of hydroxyl radicals gradually increases after one minute from the start of the reaction. Figure 5 It shows the changes in the signal peaks of superoxide radicals at different time points in the PVDF piezoelectric brush filament material system within 10 minutes. The signal peak of superoxide radicals gradually increases after one minute from the start of the reaction. This indicates that the PVDF piezoelectric brush filament material system can continuously generate active radicals with strong oxidizing properties (hydroxyl radicals and superoxide radicals). The above experimental results show that the PVDF piezoelectric brush filament material can generate a large number of oxidizing and reducing active species under mechanical force.

[0047] 3. Test on the generation of hydrogen radicals during the bending process of PVDF piezoelectric brush filaments

[0048] 0.03 g of PVDF piezoelectric brush filament material, 5 mL of deionized water, and 20 μL of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) with a concentration of 1 mo1 / L are placed in a 5-mL small beaker. The small beaker is placed on a magnetic stirrer, and the reaction is activated by the mechanical force of the rotating magnetic stir bar. The reaction time is as shown in the figure, and an electron paramagnetic resonance spectrometer is used to detect the · H seen Figure 6 generated during the activation process of the PVDF piezoelectric brush filament material. An electron paramagnetic resonance spectrum is measured under the PVDF piezoelectric brush filament material system, and a characteristic spectrum of the active radical with strong reducing property - hydrogen radical is obtained, indicating that the PVDF piezoelectric brush filament material system generates hydrogen radicals.

[0049] II. Experimental Results

[0050] The PVDF piezoelectric brush filaments prepared in this example can collect the force during the bending process of the brush filaments and convert it into charges on the surface of the brush filaments (the test results of the amount of charge generated by the PVDF piezoelectric brush filaments during the bending process are as Figure 2 shown), and further generate an appropriate amount of reactive oxygen species. It is found that the mechanism of ROSs generation by PVDF piezoelectric brush filaments during the bending process is as follows ( Figure 3 ): When the piezoelectric brush filament material is affected by external pressure and bending force, this will cause the redistribution of carriers inside the material and release additional shielding charges from the surface. The excess charges will disperse into the solution to become free charges and combine with water molecules to generate active substances such as hydroxyl radicals ( · OH) and superoxide radicals ( · O2 -) When the brush filaments are bent to the maximum extent, the bound charge will reach the minimum, and the excess shielding charge will continue to be released until the material reaches a new electrostatic equilibrium. When the bending degree of the brush filaments decreases and the polarization degree increases, the charge in the surrounding electrolyte will be adsorbed to balance the bound charge generated by the piezoelectric effect. At the same time, the charge in the electrolyte with the opposite polarity to the adsorbate will participate in the redox reaction to generate hydroxyl radicals ( · OH) and superoxide radicals ( · O2 - ). Therefore, the PVDF piezoelectric brush filament material will provide continuous charge to generate hydroxyl radicals ( · OH) and superoxide radicals ( · O2 - ) and other reactive species in the cyclic bending and water environment (the electron paramagnetic resonance spectra of hydroxyl radicals and superoxide radicals generated by the PVDF piezoelectric brush filaments during the bending process are shown in Figure 4 , Figure 5 ).

[0051] In addition, the PVDF piezoelectric brush filaments can also generate reactive species with reducing properties by bending: active hydrogen atoms ( · H) (the hydrogen radicals generated by the PVDF piezoelectric brush filaments during the bending process are shown in Figure 6 ). The active hydrogen atoms generated by the material are a reducing substance and have an antioxidant effect. When used in combination with hair growth drugs, both the active hydrogen atoms or the generated hydrogen molecules will play a role in protecting the effective components of the drugs, and the active hydrogen atoms also have a very short existence time in the air. Therefore, theoretically, the active hydrogen atoms will not affect the drug components.

[0052] From the above experimental results, it can be seen that the PVDF piezoelectric brush filaments can generate reactive oxygen species and active hydrogen atoms simultaneously.

[0053] Experimental Example 2 Preparation and Verification of Piezoelectric Head Comb Samples

[0054] I. Experimental Method

[0055] Preparation of piezoelectric head comb: By replacing some of the brush filaments of a commercially available head comb with 3D-printed PVDF piezoelectric brush filaments, the product photo is shown in Figure 7 .

[0056] Verification of the effect of the piezoelectric head comb: Simulating the daily hair combing scenario, use the head comb to brush a petri dish containing a small amount of deionized water (as shown in Figure 8 ), and use electron paramagnetic resonance spectroscopy (EPR) to detect the free radicals generated in the water body of the petri dish.

[0057] II. Experimental Results

[0058] The detection results are as shown inFigure 9 As shown in the figure, electron paramagnetic spectroscopy detection proves that the head comb can generate ROSs (hydroxyl radicals) during the brushing process, which can regulate the scalp immune microenvironment, adjust the microbial microecology, thereby sterilizing, activating the scalp tissue, activating hair follicle stem cells, and promoting hair growth. Moreover, the ROSs generated by short-term hair brushing (1 - 5 minutes) will be quickly quenched (the existence time is less than 1 s), and the residual concentration in the scalp tissue is low, which will not have a negative impact on the scalp tissue.

[0059] Based on the above experimental results, it can be seen that scalp care products made of PVDF piezoelectric brush filaments, such as piezoelectric head combs, can generate reactive oxygen free radicals and reactive hydrogen atoms, thereby playing a role in scalp care. The comparison between the piezoelectric head comb and the ordinary commercially available electric stimulation comb is as follows:

[0060] Table 1: Comparison between PVDF piezoelectric comb and commercially available comb

[0061]

[0062]

[0063] Specifically, it includes:

[0064] 1. Most commercially available products balance scalp sebum through microcurrent stimulation, laser stimulation, etc., and then promote hair growth through low-energy laser. Laser stimulation and microcurrent stimulation are restricted by the microenvironment on the scalp surface (such as dandruff, already produced sebum, etc.). The piezoelectric brush filament material can inactivate the microorganisms in the scalp that cause symptoms such as inflammation, alopecia, and dandruff by generating activity, solve the scalp problems caused by scalp microecological imbalance, and provide a good microenvironment for the action of hair growth drugs.

[0065] 2. The contact surface between the brush filament and the scalp is wider, and the action range is larger: Commercially available products perform electrical stimulation through a microcurrent device. The contact surface between the ems microcurrent device and the scalp is limited, which restricts the action effect of the commercially available microcurrent comb. However, the piezoelectric brush filament material can continuously generate charges on the surface of the brush filament through the friction and extrusion between the brush filament and the scalp, perform continuous microcurrent stimulation on the scalp, and can contact the scalp part through the hair.

[0066] 3. Energy saving and environmental protection: During the hair brushing process, the brush filament is activated by external machinery and does not require additional energy supply.

[0067] The above embodiments prove that the present invention provides a scalp care product made of self-polarized polyvinylidene fluoride. By using it for a long time in daily life, it can effectively treat inflammation, alopecia, and dandruff caused by scalp microecological imbalance, and has good application prospects.

Claims

1. Use of self-polarized polyvinylidene fluoride in the preparation of scalp care products.

2. The use according to claim 1, characterized in that: The scalp care products are combs, shampoo brushes or massage brushes.

3. The use according to claim 2, characterized in that: The self-polarized polyvinylidene fluoride is used to prepare the teeth of a comb, the bristles of a shampoo brush or the bristles of a massage brush.

4. The use according to claim 1, wherein: The scalp care products are used to remove bacteria, fungi or parasites from the scalp.

5. The use according to claim 1, wherein: The scalp care products are used to improve scalp inflammation, alopecia or dandruff.

6. A scalp care product, characterized in that: It is made with self-polarized polyvinylidene fluoride as the active material and other auxiliary materials.

7. The scalp care product according to claim 6, characterized in that: The scalp care products are combs, shampoo brushes or massage brushes.

8. The scalp care product according to claim 7, wherein: The self-polarized polyvinylidene fluoride is used to prepare the teeth of a comb, the bristles of a shampoo brush or the bristles of a massage brush.

9. The scalp care product according to claim 6, wherein: The scalp care products are used to remove bacteria, fungi or parasites from the scalp.

10. The scalp care product according to claim 6, characterized in that: The scalp care products are used to improve scalp inflammation, alopecia or dandruff.

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