Collagen repair lotion and preparation method thereof

Abstract

The invention provides a collagen emulsion for skin repair and a preparation method thereof, the collagen repair emulsion comprises the following preparation raw materials: 10-14% of a humectant, 4-6% of an emulsifier, 1-10% of a skin conditioner, 0.5-2% of an antioxidant, 15-25% of an emollient, 0.5-2% of a thickener, and the balance of water, based on the total weight of the collagen repair emulsion, the total weight of the collagen repair emulsion is 100%. The product formula of the collagen repair lotion is different from the conventional product formula. The collagen used in the product disclosed by the invention has a promoting effect on repairing, and the collagen is type I collagen. The I-type collagen is of a three-stage spiral structure formed by three alpha-chain spirals, so that the I-type collagen has higher mechanical strength and stability, and can provide powerful support and protection for skin and tissues.

Description

Technical Field

[0001] The present invention relates to the field of daily chemical technology, and in particular to a collagen repair cream and a preparation method thereof. Background Art

[0002] With the increasing attention of people to skin health, the market demand for repair skin care products continues to grow. However, most of the existing repair skin care products on the market have problems such as limited repair effect, complex ingredients, and easy allergy. Therefore, it is of great significance to develop a skin care product with high repair effect, safe ingredients, and no irritation.

[0003] For the conventional production process of repair skin care products, after the raw materials are heated, dissolved, mixed, etc., it is ensured that the raw materials are evenly dispersed and stable in the subsequent process. Then the oil phase and the water phase are mixed under the action of an emulsifier to form an emulsion system. During this process, it is necessary to control the temperature, mixing speed, etc. of the entire production environment to ensure the stability and fineness of the repair cream. Then the emulsified solution is homogenized by a homogenizer, and then sterilized, canned, and packaged.

[0004] The raw materials of repair skin care products, common ingredients include plant extracts (such as oats, aloe vera, green tea, Chinese honey locust, etc.), vitamins (such as vitamin E, vitamin C, vitamin B, etc.), minerals (such as zinc, selenium, etc.), collagen, hyaluronic acid, etc.

[0005] At present, most repair cosmetics on the market have problems such as limited repair effect and easy allergy. Therefore, it is of great significance to develop a cosmetic with high repair effect, safe ingredients, and no irritation. Summary of the Invention

[0006] In view of the defects of similar products on the market, the present invention provides a collagen cream for skin repair and a preparation method, and at the same time, the added formula is different from the existing commonly used raw materials.

[0007] A collagen repair cream, the preparation raw materials include: 10-14% of a moisturizer, 4-6% of an emulsifier, 1-10% of a skin conditioner, 0.5-2% of an antioxidant, 15-25% of an emollient, 0.5-2% of a thickener, and the balance of water is made up to 100%, calculated by weight percentage of the total weight of the collagen repair cream.

[0008] Moisturizer

[0009] The main components of the moisturizer include one or more of sodium hyaluronate, 1,2-hexanediol, glycerin, and betaine in any combination.

[0010] In one embodiment, the humectant is sodium hyaluronate, 1,2 - hexanediol, and glycerin; the weight percentages of sodium hyaluronate, 1,2 - hexanediol, and glycerin are 0.1:1.05:10 - 10.2.

[0011] In one embodiment, the humectant is sodium hyaluronate, 1,2 - hexanediol, glycerin, and betaine; the weight percentages of sodium hyaluronate, 1,2 - hexanediol, glycerin, and betaine are 0.1:1.05:10 - 10.2:1.

[0012] Emollient

[0013] The main components of the emollient include one or any combination of polydimethylsiloxane, squalane, pentaerythritol tetra(ethylhexanoate), isononyl isononanoate, and caprylic / capric triglyceride.

[0014] In one embodiment, the emollient is polydimethylsiloxane, squalane, pentaerythritol tetra(ethylhexanoate), isononyl isononanoate, and caprylic / capric triglyceride; the weight percentages of polydimethylsiloxane, squalane, pentaerythritol tetra(ethylhexanoate), isononyl isononanoate, and caprylic / capric triglyceride are 5:1:5:5:5.

[0015] Skin conditioner

[0016] The main components of the skin conditioner include one or a combination of butanediol, caprylyl glycol, phosphatidylcholine, ethoxydiglycol, ceramides, acetic acid, collagen, carnosine, fructose, and plant extracts.

[0017] In one embodiment, the main components of the skin conditioner include one or a combination of phosphatidylcholine, ethoxydiglycol, ceramides, collagen, fructose, and plant extracts. The ceramides are at least one of ceramide NS / ceramide NG (English name: CERAMIDE NS / CERAMIDE NG; CAS Number: 100403 - 19 - 8), ceramide NP, and ceramide AP.

[0018] In one embodiment, the ceramides are ceramide NS / ceramide NG, ceramide NP, and ceramide AP, and the weight percentages of ceramide NS / ceramide NG, ceramide NP, and ceramide AP are 5:3:2.

[0019] In one embodiment, the main components of the skin conditioner include one or a combination of butanediol, caprylyl glycol, phosphatidylcholine, acetic acid, collagen, carnosine, fructose, and plant extracts.

[0020] The plant extract is at least one of oat β-glucan, olive leaf extract, single-fruit hawthorn extract, ginseng root extract, Artemisia annua extract, and plant sterols.

[0021] The oat β-glucan is a non-starch polysaccharide present in the endosperm and aleurone layer cell walls of oats. It is a high-molecular polymer formed by monomer β-D-glucopyranose linked by β-(1→3) and β-(1→4) glycosidic bonds. Oat β-glucan is a short-chain glucan with a relatively small molecular weight, and the range of its relative molecular weight is 5,300 - 257,200.

[0022] The olive leaf extract has a very strong activating effect on macrophage activity. One of the functions of macrophages in the cortex is to phagocytize melanin. Olea europaea L. is a plant of the genus Olea in the family Oleaceae. The olive leaf contains active substances such as lignans, flavonoids, coumarins, secoiridoids, organic acids, and saponin compounds. Among them, oleuropein (OLE) is the most abundant active ingredient, and this bitter compound has powerful antibacterial, anti-inflammatory, and antioxidant properties.

[0023] The main active ingredients of the single-fruit hawthorn extract (CRATAEGUS MONOGINA) are flavonoids, organic acids, and triterpenoid compounds.

[0024] The Latin name of the Artemisia annua extract is Artemisia annua, and its main components include artemisinin, flavonoid compounds, volatile oils, polyphenolic compounds, etc.

[0025] The main components of the plant sterols include β-sitosterol, stigmasterol, campesterol, and sitostanol, which have anti-inflammatory, moisturizing, antioxidant, and repair functions, and the product number is EIDEW PS-203.

[0026] Emulsifier

[0027] The emulsifier is one or any combination of glyceryl isostearates, hydrogenated lecithin, plant sterols, and cetearyl alcohol.

[0028] In one embodiment, the emulsifier is glyceryl isostearates, hydrogenated lecithin, plant sterols, and cetearyl alcohol; the weight percentages of glyceryl isostearates, hydrogenated lecithin, plant sterols, and cetearyl alcohol are 0.75:0.1 - 0.11:1:3.15.

[0029] The main components of the phytosterol include β-sitosterol, stigmasterol, campesterol and sitostanol, which have anti-inflammatory, moisturizing, antioxidant and repair functions, and the product number is EIDEW PS-203.

[0030] Antioxidant

[0031] The antioxidant is tocopheryl acetate and / or p-hydroxyacetophenone.

[0032] Thickener

[0033] The thickener is one or any combination of xanthan gum, sorbitan isostearate, and copolymer of hydroxyethyl acrylate / sodium acryloyldimethyl taurate.

[0034] In one embodiment, the thickener is xanthan gum, sorbitan isostearate, and copolymer of hydroxyethyl acrylate / sodium acryloyldimethyl taurate; the weight percentages of xanthan gum, sorbitan isostearate, and copolymer of hydroxyethyl acrylate / sodium acryloyldimethyl taurate are 1:0.6:9.4.

[0035] The second aspect of the present invention provides a preparation method of the collagen repair lotion, including the following steps:

[0036] S1. Add water to the emulsifying pot and heat it.

[0037] S2. Add the antioxidant and the humectant to another container, then add the emollient, and continuously stir until the solution is transparent.

[0038] S3. Add the solution prepared in step S2 to step S1 and stir evenly.

[0039] S4. Cool down the temperature.

[0040] S5. Add the skin conditioner, thickener, and emulsifier to the emulsifying pot and continuously stir evenly to obtain the repair lotion.

[0041] Preferably, the preparation method of the collagen repair lotion includes the following steps:

[0042] S1. Add water to the emulsifying pot and heat it until the water temperature reaches about 80°C.

[0043] S2. Add the antioxidant and the humectant to another container, then add the emollient, and continuously stir and maintain the temperature at 80°C until the solution is transparent; adding the emollient in S2 can effectively encapsulate the moisturizing components.

[0044] S3. Add the solution prepared in step S2 to step S1, stir evenly, reduce the stirring speed to 60 - 70 rpm, and stir for 15 - 20 minutes.

[0045] S4. Cool down to 35-40°C, and control the stirring speed at 90-110rpm during the cooling process; control a certain stirring speed during the cooling process to keep the uniform solution from being destroyed.

[0046] S5. Add the skin conditioner, thickener and emulsifier into the emulsifying pot and continue stirring to obtain the repair lotion.

[0047] Beneficial Effects

[0048] The product formula of the collagen repair lotion of the present invention is different from the conventional product formula. The collagen used in the product of the present invention has a promoting effect on repair, and the collagen is type I collagen. Type I collagen is a triple helical structure composed of three α-chain helices, which gives it high mechanical strength and stability, and can provide strong support and protection for the skin and tissues. Type I collagen is the main component of the skin structure, occupies a high proportion of the skin weight, and plays a repairing role by helping to restore the integrity and function of the tissue.

[0049] By adding oat β-glucan and phytosterols to interact, the skin barrier is strengthened and moisture is locked, so that the repair lotion has good moisturizing and repairing effects; the olive leaf extract, hawthorn fruit extract and artemisia annua extract can relieve inflammation and are suitable for people with sensitive skin. The ginseng root extract, olive leaf extract and hawthorn fruit extract reduce free radical damage and delay aging. At the same time, adding a certain proportion of glyceryl isostearate, hydrogenated lecithin, phytosterols and cetearyl alcohol as emulsifiers can enhance the permeability of active ingredients (such as collagen, plant extracts), while stabilizing the emulsification system and enhancing moisturizing, but it will not be too greasy or heavy on the skin, affecting the use experience. Implementation

[0051] The raw materials described in this application are all commercially available.

[0052] The collagen is type I collagen. The phytosterol is of product number EIDEW PS-203.

[0053] Example 1

[0054]

[0055] Example 2

[0056]

[0057] Example 3

[0058]

[0059] Example 4

[0060]

[0061]

[0062] Example 5

[0063]

[0064]

[0065] Example 6

[0066]

[0067]

[0068] Example 7

[0069]

[0070]

[0071] The preparation method of the collagen repair lotion described in Examples 1-7 comprises the following steps:

[0072] S1. Add water to the emulsifying pot and heat to make the water temperature reach 80 °C;

[0073] S2. Add the antioxidant and the humectant to another container, then add the emollient, continuously stir and keep the temperature at 80 °C until the solution becomes transparent;

[0074] S3. Add the solution prepared in step S2 to step S1, stir evenly, reduce the stirring speed to maintain at 60-70 rpm, and stir for 15-20 minutes;

[0075] S4. Cool down to 35-40 °C, and control the stirring speed at 90-110 rpm during the cooling process; increase the stirring speed during the cooling process to keep the homogeneous solution from being damaged.

[0076] S5. Add the skin conditioner, thickener, and emulsifier to the emulsifying pot, continuously stir evenly to obtain the repair lotion.

[0077] Example 8

[0078] The milk formula described in Example 8 is the same as that in Example 2, and the differences are as follows:

[0079] S1. Add water to the emulsifying pot and heat to make the water temperature reach 80 °C;

[0080] S2. Add the antioxidant and the humectant to another container, continuously stir and keep the temperature at 80 °C until the solution becomes transparent;

[0081] S3. Add the solution prepared in step S2 into step S1, stir evenly, reduce the stirring speed and maintain it at 60 - 70 rpm, and stir for 15 - 20 minutes;

[0082] S4. Cool down to 35 - 40 °C, and control the stirring speed at 60 - 70 rpm during the cooling process;

[0083] S5. Add the skin conditioner, thickener, emulsifier, and emollient into the emulsifying pot, and continuously stir evenly to obtain the repair cream.

[0084] Performance Test

[0085] In order to better prove the beneficial effects of the technical solution provided by the present invention, experimental examples of the technical solution provided by this application are given below.

[0086] (1) Skin patch test (The test results after removing collagen in Example 2 are shown in Table 1, and the test results of Example 2 are shown in Table 2); The control group is not using the product.

[0087] Table 1

[0088]

[0089]

[0090] Table 2

[0091]

[0092] Among them, 0 represents a negative reaction (no reaction); 1 represents a doubtful reaction (only faint erythema); 2 represents a weak positive reaction (erythema reaction: erythema, infiltration, edema, and may have papules); 3 represents a strong positive reaction (vesicle reaction: erythema, infiltration, edema, papules, vesicles; the reaction may exceed the test area); 4 represents an extremely strong positive reaction (confluent vesicle reaction: obvious erythema, severe infiltration, edema, confluent vesicles; the reaction exceeds the test area).

[0093] Among the 30 subjects, 10 are male and 20 are female, and the age is 25 - 58 years old. No adverse reactions were reported during the test.

[0094] As can be seen from the table, from 0.5 h to 48 h, the subjects using the test substance did not show any reaction.

[0095] (2) Test on the change rate of skin stratum corneum moisture content

[0096] Test method: The water content of the skin stratum corneum was measured by the MPA 580 skin moisture content test probe of CK Company in Germany (the unit is expressed in C.U.). 30 subjects were tape-stripped continuously for 3 days and used the product once a day until the 7th day, and the water content of the skin stratum corneum was measured. The control group did not use the product.

[0097] Example Day 0 Day 7 Control group 34.57±7.61 31.42±6.56 Example 2 32.54±6.51 36.02±8.12 Example 4 33.13±8.35 36.11±9.10 Example 5 34.26±7.27 36.54±8.52 Example 6 31.87±7.74 34.97±8.79 Example 7 32.86±6.62 33.98±8.69 Example 8 34.89±8.65 35.23±9.17

[0098] The average value of the water content of the skin stratum corneum in the control group decreased by about 9.1% compared with that before skin barrier damage on the 0th day. The average value of the water content of the skin stratum corneum in the test sample area using the repair cream without adding collagen (removing the collagen in Example 2) decreased by about 7.62% compared with that before skin barrier damage on the 0th day; the average value of the water content of the skin stratum corneum in the test sample area using the test sample of Example 2 of the present application increased by about 10.7% compared with that before skin barrier damage on the 0th day; it shows that the repair cream of the present application has a significant moisturizing effect.

[0099] (3) Skin TEWL (trans-epidermal water loss rate) test

[0100] For 30 subjects, after being tape-stripped continuously for 3 days and using the product once a day until the 7th day, the test was carried out by a water loss rate tester (Vapometer) of Delfin Company in Finland. The rate of water loss through the skin was calculated by the change rate of air humidity over time within a specific period after contacting the skin. The unit of the measured value is g / (m 2 .h). The following data illustrate that the repair cream of the present application has a good repair effect.

[0101]

[0102]

[0103] (4) Stability experiment: The prepared repair cream was placed in an incubator at 0 °C, 25 °C, and 40 °C for 90 days to check the stability of the repair cream.

[0104] Example 0℃ 25℃ 40℃ Example 1 No change No change No change Example 2 No change No change No change Example 3 No change No change No change Example 4 Stratification Stratification Stratification Example 5 No change No change No change Example 6 No change No change No change Example 7 Stratification Stratification Stratification Example 8 Stratification Stratification Stratification

[0105] (4) Comprehensive evaluation experiment of human trial: The selected candidates for this test are the same as those in Test 1.

[0106] Use feeling scoring form

[0107] Serial number Problem Score 1 Using this sample is mild and non-irritating; □5□4□3□2□1 2 Using this sample, the texture is fresh and easy to "spread"; □5□4□3□2□1 3 Using this sample does not cause clogged pores; □5□4□3□2□1 4 Generally, I am satisfied with this sample. □5□4□3□2□1

[0108] 5 points means completely agree, 4 points means relatively agree, 3 points means neither agree nor disagree, 2 points means relatively disagree, 1 point means completely disagree. There are 30 people in total, and the total score is recorded in the following table.

[0109]

[0110]

[0111] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A collagen repair lotion, characterized in that, The preparation raw materials include: 10-14% of humectant, 4-6% of emulsifier, 1-10% of skin conditioner, 0.5-2% of antioxidant, 15-25% of emollient, 0.5-2% of thickener, and the balance of water is made up to 100%, calculated by the percentage content of the total weight of the collagen repair lotion.

2. The collagen repair lotion according to claim 1, wherein, The main components of the humectant include one or more of sodium hyaluronate, 1,2-hexanediol, glycerin, and betaine in any combination.

3. The collagen repair lotion according to claim 2, wherein The humectant is sodium hyaluronate, 1,2-hexanediol, and glycerin; the weight percentages of sodium hyaluronate, 1,2-hexanediol, and glycerin are 0.1:1.05:10 - 10.

2.

4. The collagen repair lotion according to claim 2, wherein The humectant is sodium hyaluronate, 1,2-hexanediol, glycerin, and betaine; the weight percentages of sodium hyaluronate, 1,2-hexanediol, glycerin, and betaine are 0.1:1.05:10 - 10.2:

1.

5. The collagen repair lotion according to claim 1, wherein The main components of the emollient include one or more of polydimethylsiloxane, squalane, pentaerythrityl tetra(ethylhexanoate), isononyl isononanoate, and caprylic / capric triglyceride in any combination.

6. The collagen repair lotion according to claim 1, wherein, The main components of the skin conditioner include one or more combinations of butanediol, octyldodecanol, phosphatidylcholine, ethoxydiglycol, ceramides, acetic acid, collagen, carnosine, fructose, and plant extracts.

7. The collagen repair lotion according to claim 6, wherein The ceramides are at least one of ceramide NS / ceramide NG, ceramide NP, and ceramide AP.

8. The collagen repair lotion according to claim 6, characterized in that, The plant extracts are at least one of oat β-glucan, olive leaf extract, hawthorn fruit extract, ginseng root extract, artemisia annua extract, and phytosterols.

9. The collagen repair lotion according to claim 1, wherein, The thickener is one or more of xanthan gum, sorbitan isostearate, and acryloyldimethyltaurate / VP copolymer in any combination.

10. A method for preparing the collagen repair lotion according to any one of claims 1-9, characterized in that, It includes the following steps: S1. Add water to the emulsifying pot and heat it. S2. Add the antioxidant and humectant to another container, then add the emollient, and continuously stir until the solution is transparent. S3. Add the solution prepared in step S2 to step S1 and stir evenly. S4. Cool down. S5. Add the skin conditioner, thickener, and emulsifier to the emulsifying pot and continuously stir evenly to obtain the repair lotion.

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