A multi-channel sample parallel detection device for liquid phase chip instrument

Abstract

The present invention discloses a multi-channel sample parallel detection device for a liquid chip instrument, which relates to the field of detection devices and includes a liquid chip instrument body, a pretreatment chamber is provided inside the liquid chip instrument body, a well plate box and a sample loading device are provided inside the pretreatment chamber, a lifting plate is provided at the bottom end of the well plate box, a driving component and a lifting component are provided at the bottom end of the lifting plate, and the lifting component includes a lifting rod, a moving rod is fixedly installed on both sides of the lifting rod, and the guide grooves are fixedly installed at the bottom end of the inner wall of the pretreatment chamber, and the guide grooves are divided into a flat low section and a high section, as well as an inclined lifting section. The present invention cooperates with the driving component to enable the multi-channel sample loading of the test tube to be parallel, greatly improving the detection speed and reducing manual errors. At the same time, by providing the lifting component, the situation where the liquid splashes onto the inner wall of the test tube when the sample loading device drips the reagent is reduced, thereby improving the accuracy of the detection results.

Description

Technical Field

[0001] The present invention relates to the technical field of detection devices, and in particular to a multi-channel sample parallel detection device of a liquid phase chip instrument. Background Art

[0002] As a cutting-edge device in the field of life science and medical testing, the liquid phase chip instrument is an innovative high-throughput detection platform that integrates flow cytometry and microsphere suspension array technology. It uses different fluorescent-coded microspheres modified with specific capture probes on the surface to react specifically with the sample to be tested, and then uses lasers to excite the fluorescent substances on the microspheres. By detecting the fluorescent signals, it can achieve rapid quantitative analysis of multiple target molecules (such as antigens, nucleic acids, proteins and other biomarkers) in a single well. Compared with traditional detection technologies, this device not only greatly improves detection efficiency, but also significantly reduces sample usage. It has important application value in clinical diagnosis, drug development, disease screening and other fields.

[0003] In the existing technology, in order to meet the needs of large-scale sample testing, existing liquid phase chip instruments are often equipped with multi-channel sample parallel detection devices. Through integrated design, this device can process dozens to hundreds of samples at the same time, and effectively cope with batch sample analysis tasks in scenarios such as high-throughput screening, epidemiological surveys, and drug clinical trials. However, the current multi-channel sample parallel detection device still has the problem of sample addition and oscillation mixing in sequence before the test tube enters the formal testing process in the sample pretreatment stage. If manual single sample addition is adopted, it is not only time-consuming and labor-intensive, resulting in low overall detection efficiency, but also the sample processing process is cumbersome and prone to human operation errors, making it difficult to ensure the accuracy and repeatability of the test results. In addition, manual operation may also increase the risk of cross-contamination, further affecting the detection accuracy, and cannot meet the timeliness, standardization and automation requirements of modern high-throughput detection. Summary of the Invention

[0004] The main purpose of the present invention is to propose a multi-channel sample parallel detection device for a liquid phase chip instrument, which aims to solve the problems of low detection efficiency, complex sample processing process, and difficulty in ensuring detection accuracy in the existing multi-channel sample parallel detection device of a liquid phase chip instrument, in which samples are manually added one by one.

[0005] In order to solve the above problems, the present invention proposes a multi-channel sample parallel detection device of a liquid phase chip instrument, comprising a liquid phase chip instrument body, a pretreatment chamber is provided inside the liquid phase chip instrument body, a well plate box and a sample loading device are provided inside the pretreatment chamber, the top of the well plate box is evenly provided with holes for placing test tubes, the bottom of the well plate box is provided with a lifting plate, the well plate box and the lifting plate are connected by an adjustment component, the bottom of the lifting plate is provided with a driving component for carrying the well plate box to the bottom of the sample loading device and a lifting component for making the test tubes in the well plate box close to the sample loading device, and a measuring component for judging the initial horizontal position of the well plate box is provided on one side of the lifting plate;

[0006] The lifting assembly includes a lifting rod provided at the bottom end of the lifting plate, and movable rods are fixedly installed on both sides of the lifting rod, and the movable rods are slidably installed on the inner wall of the guide groove, and the guide grooves are fixedly installed on the bottom end of the inner wall of the pretreatment chamber;

[0007] The guide grooves are divided into a straight low section and a high section, as well as an inclined lifting section, and the low section and the high section are connected through the lifting section.

[0008] Preferably, the driving assembly includes a first driving plate arranged below the lifting plate, the first driving plate is slidably mounted on the outer wall of the lifting rod, a first screw rod is threadedly mounted on the inner wall of one side of the first driving plate, one end of the first screw rod is connected to a motor, and the motor is connected to an external power supply through a wire, a first guide rod is slidably mounted on the inner wall of the first driving plate away from the first screw rod, and a positioning assembly for keeping the test tube vertical is provided on the other side of the first driving plate.

[0009] Preferably, the measuring assembly includes a first abutment block arranged on one side of the lifting plate, the bottom end of the first abutment block abuts against a positioning block, a first connecting plate is fixedly installed on one side of the positioning block, a first connecting rod is fixedly installed on the bottom end of the first connecting plate, a placement seat is fixedly installed on the other end of the first connecting rod, a first slide is fixedly installed on the bottom end of the placement seat, the first slide is slidably installed on the inner wall of the first sealed cavity, the first sealed cavity is fixedly installed in the pretreatment chamber, a second sealed cavity is fixedly installed on one side of the first sealed cavity, the first sealed cavity and the second sealed cavity are connected by a connecting channel, and a second slider is slidably installed on the inner wall of the second sealed cavity.

[0010] Preferably, the adjustment assembly includes an adjustment plate arranged between the orifice plate box and the lifting plate, the adjustment plate is fixedly installed on the bottom end of the orifice plate box, the inner wall of one corner of the adjustment plate is threaded with a second screw rod, the bottom end of the second screw rod passes through the lifting plate and is fixedly installed with an adjustment handle, the inner walls of the other triangles of the adjustment plate are all slidably installed with second guide rods, and the second guide rods are all fixedly installed on the top of the lifting plate.

[0011] Preferably, the positioning assembly includes a second driving plate fixedly mounted on one side of the first driving plate, a driving groove is opened on one side of the second driving plate, the inner wall of the driving groove is abutted with a second abutting block, a second connecting plate is provided on one side of the second abutting block, a plurality of extrusion plates are fixedly mounted on the bottom end of the second connecting plate, the plurality of extrusion plates are connected by a second connecting rod, a first limiting rod is slidably mounted on the inner wall of the second connecting rod, the first limiting rod is fixedly mounted on the inner side of the top end of the orifice plate box, a first straightening block is evenly mounted on one side of the extrusion plate, a second straightening block is provided on one side of the first straightening block, and the second straightening blocks are fixedly mounted on one side of the hole.

[0012] Preferably, one end of the second abutment block close to the driving groove is set as an inclined portion, the top of the inclined portion is set as an inclined surface, the bottom end of the inclined portion is set as a flat surface, and the cross section of the driving groove is set to be the same as the cross section of the second abutment block.

[0013] Preferably, the distance between the top end of the second driving plate and the driving groove is greater than the distance between the horizontal height of the high section and the horizontal height of the low section of the guide groove.

[0014] Preferably, a sliding groove is provided on the inner wall of the second connecting plate, the second abutment block is slidably installed on the inner wall of the sliding groove, a third guide rod is fixedly installed on the side of the second abutment block close to the sliding groove, and an elastic spring is sleeved on the outer wall of the third guide rod.

[0015] Preferably, a second limiting rod is fixedly mounted on one side of the second abutting block, and the second limiting rod is slidably mounted on the inner wall of the limiting groove, and the limiting groove is provided on the inner side of the second connecting plate.

[0016] Preferably, a disassembly hole is provided on one side of the second limiting rod, and the disassembly hole is opened on one side of the second connecting plate.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The technical solution of the present invention cooperates with the driving component and the loading device, so that the sample addition of the test tube uses multi-channel samples in parallel, realizes automated process operation, greatly improves the detection speed and reduces manual errors. At the same time, by setting the lifting component and the adjustment component, the occurrence of liquid splashing onto the inner wall of the test tube when the loading device adds reagents is reduced, thereby improving the accuracy and stability of the test results. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0020] Figure 1 Schematic diagram of the overall structure of the liquid phase chip instrument of the present invention;

[0021] Figure 2 Schematic diagram of the cross-sectional structure of the pretreatment chamber of the present invention;

[0022] Figure 3 is a schematic cross-sectional view of the lifting assembly of the present invention;

[0023] Figure 4 This invention Figure 3 Enlarged view of point A in the middle;

[0024] Figure 5 It is a structural schematic diagram of the orifice plate box of the present invention;

[0025] Figure 6 This invention Figure 5 Enlarged view of point B in the middle;

[0026] Figure 7 is a schematic cross-sectional structural diagram of the second connecting plate of the present invention;

[0027] Figure 8 It is a structural schematic diagram of the measuring component of the present invention;

[0028] Figure 9 It is a schematic cross-sectional structure diagram of the measuring component of the present invention from another perspective.

[0029] The following are the descriptions of the reference numerals:

[0030] 1. Liquid phase chip instrument body; 2. Pretreatment chamber; 3. Orifice plate box; 4. Lifting plate; 5. Sample loading device; 6. Lifting rod; 7. Moving rod; 8. Guide groove; 9. First driving plate; 10. First screw rod; 11. Motor; 12. First abutment block; 13. Positioning block; 14. First connecting plate; 15. First connecting rod; 16. Placement seat; 17. First slide plate; 18. First sealed chamber; 19. Second sealed chamber; 20. Connecting channel; 2 1. Second slider; 22. Adjustment plate; 23. Second screw rod; 24. Adjustment handle; 25. Second drive plate; 26. Drive slot; 27. Second abutment block; 28. Second connecting plate; 29. ​​Extrusion plate; 30. Second connecting rod; 31. First limiting rod; 32. First righting block; 33. Second righting block; 34. Slide; 35. Third guide rod; 36. Elastic spring; 37. Second limiting rod; 38. Limiting slot; 39. Disassembly hole. DETAILED DESCRIPTION

[0031] The following will clearly and completely describe the technical solutions of the present invention in conjunction with the accompanying drawings. Obviously, the embodiments described are only some of the embodiments of the present invention, not all of them. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0032] In the present invention, unless otherwise specified or limited, the terms "connection" and "fixation" should be understood in a broad sense. For example, "fixation" can mean fixed connection, detachable connection, or integration; mechanical connection or electrical connection; direct connection or indirect connection through an intermediate medium; internal communication between two elements or interaction between two elements, unless otherwise specified. Those skilled in the art will be able to understand the specific meanings of the above terms in the present invention based on specific circumstances.

[0033] The present invention proposes a multi-channel sample parallel detection device for a liquid phase chip instrument. The multi-channel sample parallel detection device of the liquid phase chip instrument cooperates with a driving component and a loading device 5, so that the loading of test tubes also adopts a multi-channel sample parallel method, realizing automated process operation, greatly improving the detection speed and reducing manual errors. At the same time, by setting a lifting component and an adjusting component, the occurrence of liquid splashing onto the inner wall of the test tube when the loading device 5 adds reagents is reduced, thereby improving the accuracy and stability of the detection results.

[0034] Example 1

[0035] In this embodiment, a multi-channel sample parallel detection device of a liquid phase chip instrument has a structure as follows: Figures 1 to 9When the sample is put into the bottle, the bottle is put into the bottle and the sample is put into the bottle. As shown in FIG, the present invention comprises a liquid chip instrument body 1, a pretreatment chamber 2 is provided inside the liquid chip instrument body 1, a well plate box 3 and a loading device 5 are provided inside the pretreatment chamber 2, holes for placing test tubes are evenly opened on the top of the well plate box 3, wherein the loading device 5 is provided with a dripping needle and a lateral moving device, the number of the dripping needles is the same as the number of holes in a row on the well plate box 3, and the lateral moving device enables the dripping needle to add samples to the test tubes placed on the well plate box 3 one by one, thereby improving the accuracy of adding samples and the working efficiency. A lifting plate 4 is provided at the bottom end of the well plate box 3, and the well plate box 3 and the lifting plate 4 are connected by an adjusting component, and a driving component for carrying the well plate box 3 to the bottom end of the loading device 5 and a lifting component for making the test tubes in the well plate box 3 close to the loading device 5 are provided at the bottom end of the lifting plate 4. A measuring component for judging the initial horizontal position of the well plate box 3 is provided on one side of the lifting plate 4, wherein Figures 2 to 4As shown, the driving assembly includes a first driving plate 9 arranged below the lifting plate 4, the first driving plate 9 is slidably mounted on the outer wall of the lifting rod 6, and a first screw rod 10 is threadedly mounted on the inner wall of one side of the first driving plate 9. One end of the first screw rod 10 is connected to a motor 11, and the motor 11 is connected to an external power supply through a wire. The first driving plate 9 is slidably mounted on the inner wall away from the first screw rod 10. A first guide rod is provided on the other side of the first driving plate 9 to keep the test tube vertical. After the staff places the test tube in the hole at the top of the well plate box 3, the motor 11 can be started (in this embodiment, the model of the motor 11 is LW100, and since the motor 11 belongs to a mature existing technology, Therefore, its internal structure and working principle are not described in detail), so that the motor 11 drives the well plate box 3 to move through the first screw rod 10, the first driving plate 9, the lifting rod 6 and the lifting plate 4, so that the well plate box 3 moves to the bottom end of the loading device 5, and the well plate box 3 is accurately positioned when loading. Compared with manual operation, the position of the well plate box 3 is more accurate, thereby reducing the degree of disorder of the reagent falling into the well plate box 3, reducing the generation of splashes, and thereby improving the mixing degree of the reagent and the sample, and improving the detection result. The lifting component includes a lifting rod 6 arranged at the bottom end of the lifting plate 4, and moving rods 7 are fixedly installed on both sides of the lifting rod 6. The moving rods 7 are slidably installed on the inner wall of the guide groove 8. The guide groove 8 They are all fixedly installed at the bottom end of the inner wall of the pretreatment chamber 2, and the guide grooves 8 are divided into a straight low section and a high section, as well as an inclined lifting section. The low section and the high section are connected by the lifting section. With this design, when the driving component drives the test tube in the well plate box 3 to move, the first driving plate 9 drives the lifting rod 6 to move, so that the lifting rod 6 drives the moving rod 7 to move, so that the guide groove 8 has a limiting and guiding effect on the moving rod 7, so that the moving rod 7 moves along the inner track of the guide groove 8, and the inclined lifting section design of the guide groove 8 can drive the moving rod 7 to move from the low section to the high section, thereby driving the test tube to be lifted through the lifting rod 6, the lifting plate 4 and the well plate box 3, so that the well plate box 3 can be closer to the sample loading The dripping needle on the device 5 reduces the impact force of the reagent when it enters the test tube under the action of gravity, further reduces the generation of splashes, and improves the accuracy of the test results. In the prior art, samples detected by the liquid chip instrument need to be manually added with reagents one by one, which has problems such as low detection efficiency, complicated sample processing process, and difficulty in ensuring detection accuracy. The design of the driving component and the loading device 5 of this embodiment can simultaneously add multi-channel samples to the test tubes in the well plate box 3, greatly improving the detection speed and reducing manual errors. At the same time, a lifting component is also provided to reduce the situation where the liquid splashes onto the inner wall of the test tube when the loading device 5 adds reagents, thereby improving the accuracy and stability of the test results.

[0036] Example 2

[0037] In order to further explain the first embodiment, in this embodiment, Figure 3、 Figure 7 and Figure 8 As shown, the measuring assembly includes a first abutting block 12 arranged on one side of the lifting plate 4, the bottom end of the first abutting block 12 abuts against a positioning block 13, a first connecting plate 14 is fixedly installed on one side of the positioning block 13, a first connecting rod 15 is fixedly installed on the bottom end of the first connecting plate 14, a placement seat 16 is fixedly installed on the other end of the first connecting rod 15, a first slide 17 is fixedly installed on the bottom end of the placement seat 16, the first slide 17 is slidably mounted on the inner wall of the first sealed cavity 18, the first sealed cavity 18 is fixedly mounted in the pretreatment chamber 2, a second sealed cavity 19 is fixedly mounted on one side of the first sealed cavity 18, and the first sealed cavity 18 and the second sealed cavity 19 are fixedly mounted. The sealing chambers 19 are connected by a connecting channel 20, and a second slider 21 is slidably installed on the inner wall of the second sealing chamber 19. It should be noted that the weight of the second slider 21 is set to M, and the sum of the weights of the placement seat 16 and the first slide 17 is set to m1, so that M is equal to m1+m2. Since the volume of the solvent in the test tube often accounts for three-quarters of the test tube capacity, m2 is set to the sum of the weight of the test tube and the solvent of the three-quarters test tube capacity. With this design, before adding the sample, the staff can place a test tube to be added on the placement seat 16. At this time, the first sealing chamber 18 is affected by the pressure change of the first slide 17. , the sum of the gravity of the test tube and the solvent in the test tube is m. If m is greater than m2, the first slide 17 compresses the volume of the gas in the first sealed cavity 18, causing the air pressure on the side of the first sealed cavity 18 to increase, pushing the second slide 21 upward, causing the volume in the second sealed cavity 19 to increase and the air pressure to increase. When the air pressure in the first sealed cavity 18 and the second sealed cavity 19 are equal, the first slide 17 and the second slide 21 restore the force balance. At this time, the first slide 17 drives the positioning block 13 to move through the placement seat 16, the first connecting rod 15 and the first connecting plate 14; if m is less than m2, the force on the top of the first slide 17 is reduced, causing the first The gas inside the sealed cavity 18 pushes the first slide 17 to move. At this time, the internal volume of the first sealed cavity 18 increases and the air pressure decreases, causing the gas in the second sealed cavity 19 to move into the first sealed cavity 18, increasing the air pressure in the first sealed cavity 18 and reducing the air pressure in the second sealed cavity 19. When the air pressures in the first sealed cavity 18 and the second sealed cavity 19 are equal, the first slide 17 and the second slide 21 regain force balance. At this time, the first slide 17 drives the positioning block 13 to move through the placement seat 16, the first connecting rod 15 and the first connecting plate 14. It should be noted that, according to the ideal gas law, it can be deduced that the movement of the positioning block 13 is , where V0 is the sum of the gas volumes in the first sealed cavity 18, the second sealed cavity 19, and the connecting channel 20, and A is the cross-sectional area of ​​the first slide 17. Since the sum of the gravity of the test tube and the solvent in the test tube, m, is too small relative to the sum of the weight of the placement seat 16 and the first slide 17, m1, the relationship between ∆h and m is approximately linear, thereby achieving more accurate measurement and position control within a shorter range of variation. If more accurate measurement and positioning are required, in other embodiments, a pressure sensor can be provided at the bottom end of the placement seat 16, and a positioning assembly can be provided at the bottom end of the positioning block 13. The positioning assembly can be controlled by a lifting motor, a lifting screw, and a lifting slide. The positioning block 13 is composed of a pressure sensor, which accurately measures the size of m and sends a signal to control the lifting assembly to start according to the actual size of m, thereby driving the positioning block 13 to move the appropriate distance. In addition, in this embodiment, the gas in the first sealed cavity 18, the second sealed cavity 19 and the connecting channel 20 is preferably nitrogen. At room temperature and pressure, it is close to an ideal gas and conforms to the PV=nRT law. This facilitates the accurate calculation of pressure and volume changes through the state equation, ensures the stability of the cover movement, and is chemically inert. It does not react with the materials in the device (such as metals and plastics), preventing gas deterioration or corrosion of the cavity. It is particularly suitable for scenarios involving biological samples (such as liquid phase chip instruments);

[0038] Furthermore, the adjusting assembly includes an adjusting plate 22 arranged between the orifice plate box 3 and the lifting plate 4, the adjusting plate 22 is fixedly mounted on the bottom end of the orifice plate box 3, and the inner wall of one corner of the adjusting plate 22 is threadedly mounted with a second screw rod 23, the bottom end of the second screw rod 23 passes through the lifting plate 4 and is fixedly mounted with an adjusting handle 24, the inner walls of the other triangles of the adjusting plate 22 are slidably mounted with a second guide rod, and the second guide rods are fixedly mounted on the top of the lifting plate 4, through the cooperation of the adjusting assembly and the measuring assembly, after the position of the positioning block 13 in the measuring assembly tends to be stable, the staff can rotate the adjusting handle 24 so that the adjusting handle 24 drives the adjusting plate 22 to move through the second screw rod 23, so that the adjusting plate 22 drives the first abutting block 12 to move to abut against the positioning block 13, thereby adjusting the initial position of the test tube in the orifice plate box 3. Initially, the horizontal position is used. Due to the different volumes of different samples in the test tube, for example, for general samples, the solvent in the tube often occupies two-thirds of the test tube volume while ensuring that the solvent in the tube does not splash out of the test tube during shaking and ensuring the accuracy of the test data, while the solvent in the biological sample must not exceed one-half. At this time, the biological sample is added at the dropping position of a conventional sample, which easily causes the reagent to splash onto the inner wall of the test tube when it comes into contact with the solvent, reducing the mixing effect of the solvent and the reagent, thereby affecting the test results. After adopting the adjustment component in this embodiment, the appropriate distance between the test tube and the dropping needle can be maintained during subsequent sample addition, thereby further improving the accuracy of reagent dropping, reducing the impact force when the reagent is dropped, thereby improving the mixing degree of the reagent and the solvent, and improving the accuracy of the test results.

[0039] Example 3

[0040] In this embodiment, if Figures 3 to 7As shown, the positioning assembly includes a second driving plate 25 fixedly mounted on one side of the first driving plate 9, a driving groove 26 is opened on one side of the second driving plate 25, and the inner wall of the driving groove 26 abuts against a second abutting block 27, and a second connecting plate 28 is provided on one side of the second abutting block 27, wherein the end of the second abutting block 27 close to the driving groove 26 is set as an inclined portion, the top of the inclined portion is set as an inclined surface, and the bottom end of the inclined portion is set as a flat surface. The cross section of the driving groove 26 is set to be the same as the cross section of the second abutting block 27. With this design, when the lifting assembly drives the lifting plate 4 to lift, the lifting plate 4 drives the second abutting block 27 to move through the orifice plate box 3. Since the first driving plate 9 does not move in the vertical direction, the second driving plate 25 abuts against the second The block 27 moves downward, and through the setting of the inclined surface, the vertical thrust of the driving groove 26 on the second abutting block 27 is decomposed into a horizontal thrust, thereby pushing the driving groove 26 to move in the direction close to the second connecting plate 28, so that the driving groove 26 can drive the second connecting plate 28 to move, and the bottom end of the second connecting plate 28 is fixedly installed with several extrusion plates 29, and the several extrusion plates 29 are connected by a second connecting rod 30. The inner wall of the second connecting rod 30 is slidably installed with a first limiting rod 31, and the first limiting rod 31 is fixedly installed on the inner side of the top of the orifice box 3, and the first straightening block 32 is evenly installed on one side of the extrusion plate 29, and the second straightening block 33 is provided on one side of the first straightening block 32. The second straightening block 33 is fixedly installed on one side of the hole. With this design, When the second abutment block 27 pushes the second connecting plate 28 to move, the second connecting plate 28 can drive the first straightening block 32 to move in the direction close to the test tube through the extrusion plate 29 and the second connecting rod 30, so that the first straightening block 32 and the second straightening block 33 can straighten and position the test tube, thereby avoiding the problem that the hole at the top of the orifice box 3 is often larger than the test tube diameter in order to facilitate the staff to place the test tube, thereby causing the test tube to be easily offset, and then making it easy for the reagent to fall on the inner wall of the test tube during sample addition, resulting in part of the reagent remaining on the inner wall of the test tube, making the reagent content in the solvent less than the drop amount, which affects the test result. By using the positioning component, the sample addition can be made more accurate, thereby improving the accuracy of the test result. In addition, it is necessary to supplement In addition, the distance between the top of the second driving plate 25 and the driving groove 26 is greater than the distance between the horizontal height of the high section and the horizontal height of the low section of the guide groove 8. Such a design can avoid that when the moving rod 7 moves to the high section of the guide groove 8, the moving rod 7 drives the second abutting block 27 to move through the lifting rod 6, the lifting plate 4, the orifice plate box 3 and the second connecting plate 28. If the distance between the top of the second driving plate 25 and the driving groove 26 is less than the distance between the horizontal height of the high section and the horizontal height of the low section of the guide groove 8, then at this time the second abutting block 27 moves to the top of the second driving plate 25, and one side of the second driving plate 25 no longer abuts against the second abutting block 27, so that the squeezing force of the first straightening block 32 on the test tube is insufficient, and the test tube is easily deflected under the action of inertia.This leads to a decrease in sample addition accuracy.

[0041] Furthermore, the inner wall of the second connecting plate 28 is provided with a sliding groove 34, and the second abutting block 27 is slidably installed on the inner wall of the sliding groove 34. A third guide rod 35 is fixedly installed on the side of the second abutting block 27 close to the sliding groove 34, and an elastic spring 36 is sleeved on the outer wall of the third guide rod 35. With this design, when the first straightening block 32 is tightly against one side of the test tube, the second driving plate 25 continues to rise. At this time, when the second driving plate 25 drives the second abutting block 27 to move in the direction close to the second connecting plate 28 through the driving groove 26, the second abutting block 27 can slide in the sliding groove 34 and, by squeezing the elastic spring 36, cause the elastic spring 36 to undergo elastic deformation, accumulating elasticity. The potential energy is buffered, thereby preventing the first straightening block 32 and the second straightening block 33 from applying excessive pressure to the test tube, which makes the test tube easily damaged, resulting in sample contamination, affecting the test results, and even causing the test tube to break and pollute the equipment. In addition, by providing the third guide rod 35, on the one hand, the limiting and guiding effect of the movement of the second abutment block 27 can be improved, so that the movement of the second abutment block 27 is smoother and more stable. On the other hand, it can provide protection for the elastic spring 36 when the elastic spring 36 undergoes elastic deformation, thereby preventing the elastic spring 36 from easily bending and deforming during the elastic deformation process, which shortens the service life of the elastic spring 36.

[0042] Furthermore, in this embodiment, Figures 5 to 7 As shown, a second limiting rod 37 is fixedly installed on one side of the second abutting block 27, and the second limiting rod 37 is slidably installed on the inner wall of the limiting groove 38. The limiting groove 38 is opened on the inner side of the second connecting plate 28. With this design, the second limiting rod 37 can be limited by the limiting groove 38, thereby limiting the movement trajectory of the second abutting block 27, thereby preventing the second abutting block 27 from moving out of the sliding groove 34 due to the elastic action of the elastic spring 36, which affects the subsequent operation. Furthermore, a disassembly hole 39 is provided on one side of the second limiting rod 37. The disassembly hole 39 9 is opened on one side of the second connecting plate 28, and a card block is also installed in the disassembly hole 39, and the second limiting rod 37 is slidably installed on one side of the second abutting block 27. The second limiting rod 37 and the second abutting block 27 are connected by setting a spring. With this design, the elastic spring 36 can be used for a long time. When its elasticity decays, the staff can use a slender tool such as a striker to insert it into the disassembly hole 39 and press the second limiting rod 37 into the second abutting block 27. At this time, the staff can easily take out the second abutting block 27 and replace the elastic spring 36.

[0043] The above description is only a preferred embodiment of the present invention and does not limit the patent scope of the present invention. All equivalent structural transformations made by using the contents of the present invention description and drawings under the inventive concept of the present invention, or direct / indirect application in other related technical fields are included in the patent protection scope of the present invention.

Claims

1. A multi-channel sample parallel detection device for a liquid phase chip instrument, comprising a liquid phase chip instrument body (1), characterized in that: The liquid phase chip instrument body (1) is provided with a pretreatment chamber (2) inside, and a well plate box (3) and a sample loading device (5) are provided inside the pretreatment chamber (2), the top of the well plate box (3) is evenly provided with holes for placing test tubes, the bottom of the well plate box (3) is provided with a lifting plate (4), the well plate box (3) and the lifting plate (4) are connected by an adjustment component, the bottom of the lifting plate (4) is provided with a driving component for carrying the well plate box (3) to the bottom of the sample loading device (5) and a lifting component for making the test tube in the well plate box (3) close to the sample loading device (5), and a measuring component for judging the initial horizontal position of the well plate box (3) is provided on one side of the lifting plate (4); The measuring assembly includes a first abutting block (12) arranged on one side of the lifting plate (4), the bottom end of the first abutting block (12) abuts against a positioning block (13), a first connecting plate (14) is fixedly installed on one side of the positioning block (13), a first connecting rod (15) is fixedly installed on the bottom end of the first connecting plate (14), a placement seat (16) is fixedly installed on the other end of the first connecting rod (15), a first slide plate (17) is fixedly installed on the bottom end of the placement seat (16), the first slide plate (17) is slidably installed on the inner wall of the first sealed cavity (18), the first sealed cavity (18) is fixedly installed in the pretreatment chamber (2), a second sealed cavity (19) is fixedly installed on one side of the first sealed cavity (18), the first sealed cavity (18) and the second sealed cavity (19) are connected by a connecting channel (20), and a second slider (21) is slidably installed on the inner wall of the second sealed cavity (19); The lifting assembly includes a lifting rod (6) arranged at the bottom end of the lifting plate (4), and movable rods (7) are fixedly installed on both sides of the lifting rod (6), and the movable rods (7) are slidably installed on the inner wall of the guide groove (8), and the guide groove (8) is fixedly installed on the bottom end of the inner wall of the pretreatment chamber (2); The guide grooves (8) are divided into a straight low section and a high section, and an inclined lifting section, and the low section and the high section are connected through the lifting section.

2. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 1, characterized in that: The driving assembly includes a first driving plate (9) arranged below the lifting plate (4), the first driving plate (9) is slidably mounted on the outer wall of the lifting rod (6), a first screw rod (10) is threadedly mounted on the inner wall of one side of the first driving plate (9), one end of the first screw rod (10) is connected to a motor (11), and the motor (11) is connected to an external power supply through a wire, a first guide rod is slidably mounted on the inner wall of the first driving plate (9) away from the first screw rod (10), and a positioning assembly for keeping the test tube vertical is provided on the other side of the first driving plate (9).

3. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 1, characterized in that: The adjustment assembly includes an adjustment plate (22) arranged between the orifice plate box (3) and the lifting plate (4), the adjustment plate (22) is fixedly installed on the bottom end of the orifice plate box (3), the inner wall of one corner of the adjustment plate (22) is threadedly installed with a second screw rod (23), the bottom end of the second screw rod (23) passes through the lifting plate (4) and is fixedly installed with an adjustment handle (24), the inner walls of the other triangles of the adjustment plate (22) are all slidably installed with second guide rods, and the second guide rods are all fixedly installed on the top end of the lifting plate (4).

4. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 2, characterized in that: The positioning assembly comprises a second driving plate (25) fixedly mounted on one side of the first driving plate (9); a driving groove (26) is provided on one side of the second driving plate (25); a second abutting block (27) is abutted against the inner wall of the driving groove (26); a second connecting plate (28) is provided on one side of the second abutting block (27); a plurality of extrusion plates (29) are fixedly mounted on the bottom end of the second connecting plate (28); the plurality of extrusion plates (29) are connected by a second connecting rod (30); a first limiting rod (31) is slidably mounted on the inner wall of the second connecting rod (30); the first limiting rod (31) is fixedly mounted on the inner side of the top end of the orifice plate box (3); a first straightening block (32) is evenly mounted on one side of the extrusion plate (29); a second straightening block (33) is provided on one side of the first straightening block (32); and the second straightening block (33) is fixedly mounted on one side of the hole.

5. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 4, characterized in that: One end of the second abutting block (27) close to the driving groove (26) is set as an inclined portion, the top end of the inclined portion is set as an inclined surface, the bottom end of the inclined portion is set as a flat surface, and the cross section of the driving groove (26) is set to be the same as the cross section of the second abutting block (27).

6. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 4, characterized in that: The distance between the top end of the second driving plate (25) and the driving groove (26) is greater than the distance between the horizontal height of the high section and the horizontal height of the low section of the guide groove (8).

7. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 4, characterized in that: The inner wall of the second connecting plate (28) is provided with a sliding groove (34), the second abutting block (27) is slidably mounted on the inner wall of the sliding groove (34), a third guide rod (35) is fixedly mounted on a side of the second abutting block (27) close to the sliding groove (34), and an elastic spring (36) is sleeved on the outer wall of the third guide rod (35).

8. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 4, characterized in that: A second limiting rod (37) is fixedly mounted on one side of the second abutting block (27). The second limiting rod (37) is slidably mounted on the inner wall of a limiting groove (38). The limiting groove (38) is opened on the inner side of the second connecting plate (28).

9. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 8, characterized in that: A disassembly hole (39) is provided on one side of the second limiting rod (37), and the disassembly hole (39) is opened on one side of the second connecting plate (28).

Images