Column tube system and generator

Abstract

The application discloses a column tube system and a generator, the column tube system comprising a chromatographic column, elastic plugs and a support, the chromatographic column being provided with two openings at two axial ends thereof; the two elastic plugs are connected with the two ends of the chromatographic column respectively and used for sealing the openings of the chromatographic column; the support comprises a first support leg, two limiting plates being arranged on the first support leg and spaced apart along a first direction, the chromatographic column and the two elastic plugs being located between the two limiting plates, and the two elastic plugs abutting against the two limiting plates respectively. The column tube system disclosed by the application is provided with the support, the support being provided with the two limiting plates which are spaced apart, the chromatographic column is clamped between the two limiting plates when the chromatographic column is installed, the elastic plugs at the two ends of the chromatographic column abut against the two limiting plates respectively, the chromatographic column is extruded and limited by the two limiting plates, the installation stability of the chromatographic column in the production process is improved, and the liquid leakage probability is reduced.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of automatic production, and particularly relates to a column tube system and a generator. BACKGROUND

[0002] A radioisotope generator can provide a short half-life nuclide with no carrier, high specific activity and high radioactivity concentration for people many times, safely and conveniently, so it is widely used in the fields of medicine, industry, scientific research and the like. The short half-life nuclide obtained from the radioisotope generator can be directly applied or made into various labeled compounds (including drugs) for application.

[0003] In the related art, the generator column tube system is divided into two categories, one is a hard pipeline, which is easy to realize automatic production, but the pipeline sealing plug is easy to slip off, and has a risk of radioactive leakage, and the other is a soft pipeline, which cannot complete automation and has a slow production speed.

[0004] In actual production, the generator column tube system is difficult to realize automatic production, high production efficiency, low radioactive leakage risk and the like. SUMMARY

[0005] Embodiments of the present application provide a column tube system and a generator, the chromatographic column is convenient for automatic fixation and self-fastening in the production process of the generator, so as to improve production efficiency, ensure the stability and consistency of the structure, reduce connection errors caused by human operation, and reduce labor intensity and production cost.

[0006] Embodiments of the first aspect of the present application provide a column tube system, comprising a chromatographic column, an elastic plug and a support, the chromatographic column is provided with two openings at two ends in the axial direction thereof; two elastic plugs are connected with the two ends of the chromatographic column respectively, and are used for sealing the openings of the chromatographic column; the support comprises a first leg, the first leg is provided with two limiting plates which are arranged at intervals along a first direction, the chromatographic column and the two elastic plugs are located between the two limiting plates, and the two elastic plugs abut against the two limiting plates respectively.

[0007] According to the implementation manner of the first aspect of the present application, the column tube system further comprises a perfusion tube and an efflux tube, the perfusion tube and the efflux tube are connected with one elastic plug respectively and are both in communication with the chromatographic column, the perfusion tube is used for conveying material into the chromatographic column, and the efflux tube is used for discharging material in the chromatographic column.

[0008] According to the implementation manner of the first aspect of the present application, the support further comprises two second legs, the two second legs are both connected with the first leg, the second leg comprises a second supporting plate and a second groove formed by the second supporting plate, and at least part of the perfusion tube and at least part of the efflux tube are located in the second grooves of the two second legs respectively.

[0009] According to an embodiment of the first aspect of the present application, the two second legs are located on the same side of the first leg in the first direction; the support further comprises a mounting plate, the mounting plate is located on the side of the second leg away from the first leg and connected with both of the two second legs, the mounting plate is provided with a perfusion through hole and an outflow through hole penetrating along the first direction, the perfusion through hole is communicated with the perfusion pipe, and the outflow through hole is communicated with the outflow pipe.

[0010] According to an embodiment of the first aspect of the present application, the perfusion needle assembly comprises a first needle seat and a perfusion needle pipe connected with the first needle seat, the first needle seat is connected with the mounting plate, so that the perfusion needle pipe is communicated with the perfusion pipe through the perfusion through hole; the outflow needle assembly comprises a second needle seat and an outflow needle pipe connected with the second needle seat, the second needle seat is connected with the mounting plate, so that the outflow needle pipe is communicated with the outflow pipe through the outflow through hole.

[0011] According to an embodiment of the first aspect of the present application, a plurality of first limiting pieces are protrudingly arranged on the side of the mounting plate away from the first leg, a part of the first limiting pieces are arranged around the perfusion through hole, another part of the first limiting pieces are arranged around the outflow through hole, a limiting groove is formed between any two adjacent first limiting pieces; at least one second limiting piece is protrudingly arranged on the first needle seat and the second needle seat, when the second limiting piece of the first needle seat is inserted into any one limiting groove, the first needle seat is connected with the mounting plate, when the second limiting piece of the second needle seat is inserted into any one limiting groove, the second needle seat is connected with the mounting plate.

[0012] According to an embodiment of the first aspect of the present application, the mounting plate is further provided with an avoiding hole penetrating along the first direction, the avoiding hole is located between the perfusion through hole and the outflow through hole.

[0013] According to an embodiment of the first aspect of the present application, the first leg comprises a first support plate and a first recess and a third recess formed by the first support plate, the first recess is located between the limiting plates, and at least part of the color column is located in the first recess; the outflow pipe comprises a first segment and a second segment arranged in sequence, at least part of the first segment is located in the third recess. At least part of the second segment is located in the second recess.

[0014] According to an embodiment of the first aspect of the present application, one end of the first segment away from the second segment protrudes out of the third recess and is connected with the elastic plug.

[0015] The embodiment of the first aspect of the present application provides a generator, which comprises a reaction tank and the column pipe system of any one of the above embodiments, and the reaction tank is provided with a sealed cavity, and the color column is located in the sealed cavity.

[0016] The column pipe system of the present application is provided with a support, two limiting plates are arranged on the support, when the chromatographic column is installed, the chromatographic column is clamped between the two limiting plates, the elastic plugs at both ends of the chromatographic column abut against the two limiting plates respectively, the chromatographic column is limited by extrusion of the limiting plates at both ends, the installation stability of the chromatographic column in the production process is improved, and the liquid leakage probability is reduced. By clamping the chromatographic column by the limiting plates at both sides during installation, the dismounting speed of the chromatographic column is improved, the manual operation steps are reduced, the labor intensity and operation difficulty of workers are reduced, the workers are protected from radioactive radiation, and the production speed is increased. The support is arranged for installing the chromatographic column, the dimensional consistency of the chromatographic column after multiple installations is improved, the error caused by manual operation is avoided, and the installation accuracy of the chromatographic column is improved. BRIEF DESCRIPTION OF DRAWINGS

[0017] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required to be used in the embodiments of the present application will be briefly introduced as follows, and other drawings can be obtained by those of ordinary skill in the art without creative labor on the premise that the drawings are not creative labor.

[0018] Figure 1 The front view structural schematic diagram of the column pipe system of some embodiments of the present application is shown.

[0019] Figure 2 The front view structural schematic diagram of a support of an example is shown.

[0020] Figure 3 The front view structural schematic diagram of a chromatographic column and an elastic plug of an example is shown.

[0021] Figure 4 The front view structural schematic diagram of a chromatographic column, an elastic plug, a perfusion pipe and an outflow pipe of an example is shown.

[0022] Figure 5 The top view structural schematic diagram of a support of an example is shown.

[0023] Figure 6 The side view structural schematic diagram of a column pipe system of an example is shown.

[0024] Figure 7 The sectional view structural schematic diagram of a generator of an example is shown.

[0025] Figure 8 The exploded view structural schematic diagram of a generator of an example is shown.

[0026] Reference signs:

[0027] 10, column pipe system; 20, reaction tank; 21, sealing cavity; 30, sealing plug; 40, cover body; 50, handle; 60, shell;

[0028] 100, color column

[0029] 200, elastic plug

[0030] 300, support; 310, first leg; 311, limiting plate; 312, first support plate; 313, first groove; 314, third groove; 315, second clamping piece; 320, second leg; 321, second support plate; 322, second groove; 323, first clamping piece; 330, mounting plate; 331, perfusion through hole; 332, outflow through hole; 333, first limiting piece; 334, limiting groove; 335, avoiding hole; 336, mounting hole;

[0031] 400, perfusion pipe

[0032] 500, outflow pipe; 510, first section; 520, second section

[0033] 600, communication piece

[0034] 700, perfusion needle assembly; 710, first needle seat; 711, second limiting piece; 720, perfusion needle pipe

[0035] 800, outflow needle assembly; 810, second needle seat; 820, outflow needle pipe; 830, filter piece

[0036] x, first direction DETAILED DESCRIPTION

[0037] The features and exemplary embodiments of various aspects of the present application will be described in detail below with reference to the drawings. The following detailed description is provided to provide a better understanding of the present application, its technical solutions and advantages. It should be understood that the specific embodiments described herein are intended to explain the present application, not to limit the present application. The present application can be implemented without some of the specific details described below. The following description of the embodiments is merely intended to provide a better understanding of the present application by showing examples of the present application.

[0038] It is to be noted that the relative terms such as first and second and the like are used herein only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between such entities or operations. Moreover, the terms "comprises", "comprising", or any other variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but can include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by an "includes" statement does not exclude the existence of additional elements in the process, method, article, or apparatus that includes the element.

[0039] To solve the technical problems involved in the background art, the applicant provides a column system, comprising a column, an elastic plug and a bracket, the column is provided with two openings at its two axial ends respectively; two elastic plugs are connected with the two ends of the column respectively, for sealing the openings of the column; the bracket comprises a first leg, the first leg is provided with two limiting plates which are spaced apart along a first direction, the column and the two elastic plugs are located between the two limiting plates, and the two elastic plugs abut against the two limiting plates respectively.

[0040] The column system of the present application, by providing a bracket, the bracket is provided with two limiting plates which are spaced apart, so that when the column is installed, the column is clamped between the two limiting plates, and the elastic plugs at both ends of the column abut against the two limiting plates respectively, so that the column is extruded and limited by the two limiting plates at both ends, improving the installation stability of the column in the production process, reducing the probability of liquid leakage. By making the column only be clamped by the two limiting plates during installation, the disassembly and assembly speed of the column is improved, the manual operation steps are reduced, the labor intensity and operation difficulty of workers are reduced, the workers are protected from radioactive radiation, and the production speed is increased. By providing a bracket for installing the column, the dimensional consistency of the column during multiple installations is improved, errors caused by human operation are avoided, and the installation accuracy of the column is improved.

[0041] The column system provided by the embodiments of the present application will be described below with reference to the accompanying drawings. In the drawings, the sizes in the drawings are not necessarily proportional to the actual sizes.

[0042] Please refer to Figures 1 to 3 , Figure 1 is a front view structural schematic diagram of the column system of some embodiments of the present application; Figure 2 is a front view structural schematic diagram of a bracket of an example; Figure 3 is a front view structural schematic diagram of a column and an elastic plug of an example.

[0043] As Figures 1 to 3As shown, the application provides a column tube system 10, which comprises a chromatographic column 100, elastic plugs 200 and a bracket 300. The chromatographic column 100 is provided with two openings (not shown) at its two axial ends. The elastic plugs 200 are connected to the two ends of the chromatographic column 100 respectively, and are used to seal the openings of the chromatographic column 100. The bracket 300 comprises a first leg 310, which is provided with two limiting plates 311 arranged at intervals in a first direction (x direction in the figure). The chromatographic column 100 and the elastic plugs 200 are located between the two limiting plates 311, and the elastic plugs 200 abut against the limiting plates 311 respectively.

[0044] Optionally, the interval of the two limiting plates 311 in the first direction x is greater than the length of the chromatographic column 100 and less than the total length of the installation of the chromatographic column 100 and the two elastic plugs 200. When the chromatographic column 100 is clamped between the two limiting plates 311, the elastic plugs 200 will be extruded by the two limiting plates 311 and will be elastically deformed to a certain extent. This can improve the installation stability of the chromatographic column 100, and can also reduce the probability of leakage caused by the disengagement of the elastic plugs 200 from the chromatographic column 100.

[0045] Optionally, the bracket 300 has certain wear resistance and corrosion resistance. The elastic plug 200 has corrosion resistance and high elasticity. It should be noted that any material with elasticity and corrosion resistance is within the protection scope of the embodiment, such as polyurethane, polysiloxane and other high molecular materials. The person skilled in the art can select appropriate materials as the elastic plug 200 according to the actual use condition. The chromatographic column 100 can be a glass column.

[0046] Optionally, the sealing of the elastic plug 200 to the opening of the chromatographic column 100 can include one or more combinations of the following sealing methods: plug aluminum cover gland sealing, sealing ring elastic sealing and threaded sealing ring end face sealing.

[0047] The column pipe system 10 of the present application is provided with the support 300, the two limiting plates 311 are arranged on the support 300, when the color column 100 is installed, the color column 100 is clamped between the two limiting plates 311, and the elastic plugs 200 at both ends of the color column 100 abut against the two limiting plates 311, so that the color column 100 is limited by the two limiting plates 311, the installation stability of the color column 100 in the production process is improved, and the liquid leakage probability is reduced. By clamping the color column 100 by the two limiting plates 311 during installation, the dismounting speed of the color column 100 is improved, the manual operation steps are reduced, the labor intensity and operation difficulty of workers are reduced, the workers are protected from radioactive radiation, and the production speed is increased. The support 300 is arranged for installing the color column 100, the dimensional consistency of the color column 100 during multiple installations is improved, the error caused by manual operation is avoided, and the installation accuracy of the color column 100 is improved. The column pipe system of the present application is compatible with hard pipes and soft pipes, can adapt to various complex pipeline arrangements and space limitations, and can be more conveniently installed and adjusted in cooperation with the support.

[0048] Please refer to Figures 1 to 4 , Figure 4 A front view structural schematic diagram of an example color column, elastic plug, perfusion pipe and outflow pipe is shown.

[0049] As Figures 1 to 4 shown, in some embodiments, the column pipe system 10 further comprises a perfusion pipe 400 and an outflow pipe 500, the perfusion pipe 400 and the outflow pipe 500 are connected with an elastic plug 200 respectively and are both communicated with the color column 100, the perfusion pipe 400 is used for conveying materials into the color column 100, and the outflow pipe 500 is used for discharging materials in the color column 100.

[0050] Optionally, the elastic plug 200 is provided with a through hole (not shown) for fixing the perfusion pipe 400 and the outflow pipe 500, the perfusion pipe 400 and the outflow pipe 500 respectively extend into the through holes of the two elastic plugs 200 and are fixedly connected with the elastic plugs 200, so as to realize the communication between the perfusion pipe 400 and the outflow pipe 500 and the color column 100. The perfusion pipe 400, the outflow pipe 500 and the elastic plug 200 can be connected by welding, gluing, clamping and the like.

[0051] Optionally, the color column 100 is provided with an adsorbent, the perfusion pipe 400 is used for perfusing sodium chloride leaching solution into the color column 100, and the outflow pipe 500 is used for discharging radioactive reaction solution. The elastic plug 200 connected with the perfusion pipe 400 is located above the color column 100, and the elastic plug 200 connected with the outflow pipe 500 is located below the color column 100.

[0052] Optionally, the infusion tube 400 and the outflow tube 500 can be rigid or flexible tubing. In this embodiment, the infusion tube 400 and the outflow tube 500 are both flexible hoses for illustration.

[0053] Optionally, the limiting plate 311 is provided with a through hole (not shown) that allows the injection tube 400 and the outflow tube 500 to pass through, so that the injection tube 400 and the outflow tube 500 can pass through the through hole and connect with the elastic plug 200.

[0054] The column tube system 10 of this application uses flexible hoses for both the injection pipe 400 and the outflow pipe 500. Flexible hoses offer the following advantages: 1) high flexibility, adapting to various complex pipe layouts and space constraints; 2) effective absorption of vibration and impact, reducing mechanical stress on the support 300 and the color layer column 100, extending the service life of the equipment; 3) easier operation and installation compared to rigid pipes, facilitating maintenance and repair. By connecting both the injection pipe 400 and the outflow pipe 500 to the elastic plug 200, when the elastic plug 200 and the color layer column 100 are engaged with the support 300, the elastic plug 200 also provides some auxiliary positioning for the injection pipe 400 and the outflow pipe 500. By providing through holes on the limiting plate 311 that allow the injection tube 400 and the outflow tube 500 to pass through, the through holes on the limiting plate 311 can also provide a certain auxiliary positioning function for the injection tube 400 and the outflow tube 500 when they are connected to the elastic plug 200.

[0055] In some alternative embodiments, the support 300 further includes two second legs 320, both of which are connected to the first leg 310. Each second leg 320 includes a second support plate 321 and a second groove 322 formed by the second support plate 321, with at least a portion of the infusion tube 400 and at least a portion of the outflow tube 500 located in the second grooves 322 of each of the two second legs 320.

[0056] Optionally, the two second legs 320 are located on the same side of the first leg in the first direction, and the two second legs 320 and the first leg 310 together form a Y shape.

[0057] Optional, such as Figure 2 As shown, the second groove 322 is partially formed by the second support plate 321, that is, the second support plate 321 is a semi-circular arc plate.

[0058] In another embodiment, the second groove 322 can be completely surrounded by the second support plate 321, that is, the second support plate 321 is a sleeve, and the injection pipe 400 and the outflow pipe 500 can extend into the sleeve from one end opening of the sleeve.

[0059] Optionally, the second leg 320 further comprises a first clamping member 323, which is connected with the second support plate 321 and located on the side of the second support plate 321 facing the second groove 322. The first clamping member 323 is used to fix the perfusion tube 400 or the outflow tube 500 located in the second groove 322. Since the perfusion tube 400 and the outflow tube 500 are both flexible tubes, the perfusion tube 400 and the outflow tube 500 can be conveniently clamped into the first clamping member 323 to realize the fixed connection of the perfusion tube 400, the outflow tube 500 and the second leg 320.

[0060] The column system 10 of the present application, by providing two second legs 320 for installing the perfusion tube 400 and the outflow tube 500, improves the dimensional consistency of the multiple installations of the perfusion tube 400 and the outflow tube 500, avoids the errors that may be caused by human operation, and further improves the installation accuracy of the perfusion tube 400 and the outflow tube 500. By providing the first clamping member 323 for fixing the perfusion tube 400 and the outflow tube 500, the disassembly and assembly speed of the perfusion tube 400 and the outflow tube 500 is improved, the manual operation steps are reduced, and the labor intensity and operation difficulty of workers are reduced.

[0061] In some optional embodiments, the first leg 310 comprises a first support plate 312 and a first groove 313 and a third groove 314 formed by the first support plate 312. The first groove 313 is located between the two limiting plates 311, and at least part of the color layer column 100 is located in the first groove 313. The outflow tube 500 comprises a first section 510 and a second section 520 arranged in sequence, at least part of the first section 510 is located in the third groove 314, and at least part of the second section 520 is located in the second groove 322.

[0062] Optionally, the first groove 313 and the third groove 314 extend along the first direction x.

[0063] Optionally, the extension direction of the first groove 313 and the third groove 314 intersects the first direction x.

[0064] Optionally, as shown in Figure 2 The first groove 313 and the third groove 314 are partially enclosed by the second support plate 321, that is, the second support plate 321 is a semicircular arc-shaped plate arranged side by side, and is used to accommodate the color layer column 100 and the outflow tube 500, respectively.

[0065] In another embodiment, the third groove 314 can be completely surrounded by the first support plate 312, that is, a part of the first support plate 312 is a sleeve, and the first section 510 can be inserted into the sleeve from one end opening of the sleeve.

[0066] Optionally, one end of the first section 510 away from the second section 520 protrudes out of the third groove 314 and is connected with the elastic plug 200.

[0067] Optionally, the first leg 310 further comprises a second clamping piece 315, which is connected with the first support plate 312 and located on the side of the first support plate 312 facing the third groove 314. The second clamping piece 315 is used to fix the first section 510 located in the third groove 314. Since the effluent pipe 500 is a flexible pipe, the first section 510 of the effluent pipe 500 can be conveniently clamped into the second clamping piece 315 to realize the fixed connection of the first section 510 and the first leg 310.

[0068] The column pipe system 10 of the present application improves the disassembly and assembly speed of the effluent pipe 500 by providing the second clamping piece 315 for the first section 510 of the effluent pipe 500, reduces the manual operation steps, and reduces the labor intensity and operation difficulty of workers. By locating a part of the effluent pipe 500 in the second groove 322 and another part in the third groove 314, the effluent pipe 500 is in communication with the lower end of the chromatographic column 100 while being limited by the second groove 322 and the third groove 314 respectively, thereby realizing the fixed connection of the effluent pipe 500 with the first leg 310 and the second leg 320.

[0069] Please refer to Figures 1 to 5 , Figure 5 a top view structural schematic diagram of an example support is shown.

[0070] As Figures 1 to 5 shown, in some optional embodiments, the support 300 further comprises a mounting plate 330, which is located on the side of the second leg 320 away from the first leg 310 and connected with both second legs 320. The mounting plate 330 is provided with a perfusion through hole 331 and an effluent through hole 332 penetrating along the first direction x, the perfusion through hole 331 being in communication with the perfusion pipe 400, and the effluent through hole 332 being in communication with the effluent pipe 500.

[0071] Optionally, the column pipe system 10 further comprises a communication piece 600, two communication pieces 600 are clamped on the perfusion through hole 331 and the effluent through hole 332 respectively and connected with the perfusion pipe 400 and the effluent pipe 500 respectively. One end of the perfusion pipe 400 is connected with the mounting plate 330 through the communication piece 600, and the perfusion pipe 400 is in communication with the perfusion through hole 331, and the other end is connected with the chromatographic column 100 through the elastic plug 200. One end of the effluent pipe 500 is connected with the mounting plate 330 through the communication piece 600, and the effluent pipe 500 is in communication with the effluent through hole 332, and the other end is connected with the chromatographic column 100 through the elastic plug 200.

[0072] The column pipe system 10 of the present application enables the perfusion pipe 400 and the effluent pipe 500 to be connected with the mounting plate 330 by providing the communication piece 600, and the perfusion pipe 400 is in communication with the perfusion through hole 331, and the effluent pipe 500 is in communication with the effluent through hole 332.

[0073] Please refer to Figures 1 to 6 , Figure 6 A side view of an example column-tube system is shown. The diagram is designed to more clearly illustrate the features of the column-tube system. Figure 1 and Figure 6 The infusion needle assembly, outflow needle assembly and mounting plate are set separately. In practical applications, the infusion needle assembly and outflow needle assembly can be connected to the mounting plate.

[0074] like Figures 1 to 6 As shown, in some optional embodiments, the column tube system 10 further includes an infusion needle assembly 700 and an outflow needle assembly 800. The infusion needle assembly 700 includes a first needle seat 710 and an infusion needle tube 720 connected to the first needle seat 710. The first needle seat 710 is connected to a mounting plate 330, such that the infusion needle tube 720 communicates with the infusion tube 400 through an infusion through-hole 331. The outflow needle assembly 800 includes a second needle seat 810 and an outflow needle tube 820 connected to the second needle seat 810. The second needle seat 810 is connected to the mounting plate 330, such that the outflow needle tube 820 communicates with the outflow tube 500 through an outflow through-hole 332.

[0075] Optionally, the first needle hub 710 and the infusion needle tube 720 can be connected by means of Luer connector, snap fastener, straight-insertion connector, heparin cap, quick-release connector, sealing ring, etc., and the second needle hub 810 and the outflow needle tube 820 can be connected by means of Luer connector, snap fastener, straight-insertion connector, heparin cap, quick-release connector, sealing ring, etc.

[0076] Optionally, when the infusion tube 400 and the outflow tube 500 are mounted on the mounting plate 330 via the connecting member 600, the infusion needle 720 is connected to the infusion tube 400 via one connecting member 600, and the outflow needle 820 is connected to the outflow tube 500 via another connecting member 600.

[0077] Optionally, the outflow needle assembly 800 may also include a filter 830, which is in communication with the outflow needle tube 820 and is used to filter air in the solution flowing through the outflow needle tube 820.

[0078] Optionally, the side of the mounting plate 330 away from the first leg 310 is provided with a plurality of first limiting pieces 333 protruding therefrom, a portion of the first limiting pieces 333 are arranged around the perfusion through hole 331, another portion of the first limiting pieces 333 are arranged around the outflow through hole 332, and a limiting slot 334 is formed between any two adjacent first limiting pieces 333. The first needle seat 710 and the second needle seat 810 are each provided with at least one second limiting piece 711 protruding therefrom, and the first needle seat 710 is connected to the mounting plate 330 when the second limiting piece 711 of the first needle seat 710 extends into any one of the limiting slots 334. The second needle seat 810 is connected to the mounting plate 330 when the second limiting piece 711 of the second needle seat 810 extends into any one of the limiting slots 334.

[0079] Optionally, the first needle seat 710 and the second needle seat 810 are each provided with four second limiting pieces 711 protruding therefrom, and the mounting plate 330 is provided with four first limiting pieces 333 around the perfusion through hole 331 and another four first limiting pieces 333 around the outflow through hole 332.

[0080] The column system 10 of the present application is provided with a plurality of first limiting pieces 333 on the mounting plate 330, a limiting slot 334 is formed between any two adjacent first limiting pieces 333, and the first needle seat 710 is provided with a plurality of second limiting pieces 711 protruding therefrom, so that when the second limiting piece 711 of the first needle seat 710 extends into the limiting slot 334, the first needle seat 710 and the mounting plate 330 are limited by the first limiting piece 333 and the second limiting piece 711, and the first needle seat 710 is connected to the mounting plate 330 and cannot rotate relative to the mounting plate 330. The second needle seat 810 is provided with a plurality of second limiting pieces 711 protruding therefrom, so that when the second limiting piece 711 of the second needle seat 810 extends into the limiting slot 334, the second needle seat 810 and the mounting plate 330 are limited by the first limiting piece 333 and the second limiting piece 711, and the second needle seat 810 is connected to the mounting plate 330 and cannot rotate relative to the mounting plate 330.

[0081] In some optional embodiments, the mounting plate 330 is further provided with an avoiding hole 335 extending in the first direction x, and the avoiding hole 335 is located between the perfusion through hole 331 and the outflow through hole 332.

[0082] Optionally, the avoiding hole 335 is used to install a sealing plug, so that the color column 100 is located in the sealed cavity during reaction.

[0083] Please refer to Figure 5 , Figure 7 and Figure 8 , Figure 7 a sectional view of an example generator is shown; Figure 8 an exploded view of an example generator is shown.

[0084] As Figure 5 , Figure 7 and Figure 8 shown, the application also discloses a generator, comprising a reaction tank 20 and the column pipe system 10 of any of the above embodiments, the reaction tank 20 is provided with a sealed cavity 21, and the chromatographic column 100 is located in the sealed cavity 21.

[0085] Optionally, the generator further comprises a sealing plug 30, a cover 40, a handle 50 and a shell 60. The reaction tank 20 is a lead tank, and the sealing plug 30 is a lead plug. When the support 300 is installed on the reaction tank 20, the chromatographic column 100 extends into the sealed cavity 21, and the sealing plug 30 closes the outlet of the sealed cavity 21 through the avoiding hole 335 on the mounting plate 330, so that the chromatographic column 100 is located in a sealed environment. The shell 60 and the cover 40 are wrapped outside the reaction tank 20, the handle 50 is connected with the cover 40, and is used for facilitating the movement of the generator.

[0086] Optionally, the mounting plate 330 is further provided with a mounting hole 336 penetrating in the first direction x. When the bolt passes through the mounting hole 336 and is connected with the reaction tank 20, the support 300 is fixedly installed on the reaction tank 20.

[0087] Optionally, the mounting holes 336 are arranged around the perfusion through hole 331 and the outflow through hole 332, and the number of the mounting holes 336 around the perfusion through hole 331 and the outflow through hole 332 is different, so that the front and back of the support 300 can be distinguished by the different number of mounting holes 336 during installation, and the probability of the support 300 being installed reversely is reduced.

[0088] The above is merely a specific implementation of the application, and those skilled in the art can clearly understand that, for the convenience and brevity of description, the specific working process of the above-described system, module and unit can refer to the corresponding process in the foregoing embodiments, which will not be described here. It should be understood that the protection scope of the application is not limited to this, and any person skilled in the art can easily think of various equivalent modifications or replacements within the technical range disclosed in the application, and these modifications or replacements should be covered in the protection scope of the application.

Claims

1. A column system, characterized by The application relates to a chromatographic column device. The chromatographic column device comprises: a chromatographic column having two openings at two axial ends thereof; two elastic plugs respectively connected with the two ends of the chromatographic column for sealing the openings of the chromatographic column; a support comprising a first leg provided with two limiting plates spaced apart along a first direction, the chromatographic column and the two elastic plugs being located between the two limiting plates, and the two elastic plugs abutting against the two limiting plates to improve the stability of the chromatographic column during production, the first leg comprising a first supporting plate and a first groove and a third groove formed by the first supporting plate, the first groove being located between the two limiting plates, and at least part of the chromatographic column being located in the first groove; the support further comprising two second legs, each of the two second legs being connected with the first leg, and each of the second legs comprising a second supporting plate and a second groove formed by the second supporting plate; a perfusion pipe and an efflux pipe, each of the perfusion pipe and the efflux pipe being connected with one of the elastic plugs and communicating with the chromatographic column, the perfusion pipe being used for conveying materials into the chromatographic column, and the efflux pipe being used for discharging materials in the chromatographic column, at least part of the perfusion pipe and at least part of the efflux pipe being located in the second groove of each of the two second legs; 2. The column system of claim 1, wherein, wherein the efflux pipe comprises a first section and a second section arranged in sequence, at least part of the first section being located in the third groove, and at least part of the second section being located in the second groove. The two second legs are located on the same side of the first leg in the first direction; 3. The column system of claim 2, wherein, the support further comprising a mounting plate located on the side of each of the second legs away from the first leg and connected with the two second legs, the mounting plate being provided with a perfusion through hole and an efflux through hole penetrating through along the first direction, the perfusion through hole communicating with the perfusion pipe, and the efflux through hole communicating with the efflux pipe. The application further relates to a chromatographic column device. The perfusion needle assembly comprises a first needle seat and a perfusion needle tube connected with the first needle seat, and the first needle seat is connected with the mounting plate, so that the perfusion needle tube communicates with the perfusion pipe through the perfusion through hole; 4. The column system of claim 3, wherein, the efflux needle assembly comprises a second needle seat and an efflux needle tube connected with the second needle seat, and the second needle seat is connected with the mounting plate, so that the efflux needle tube communicates with the efflux pipe through the efflux through hole. The side of the mounting plate away from the first leg is provided with a plurality of first limiting pieces protruding, a part of the first limiting pieces being arranged around the perfusion through hole, and another part of the first limiting pieces being arranged around the efflux through hole, a limiting groove being formed between any two adjacent first limiting pieces; at least one second limiting piece is protrudingly arranged on each of the first needle seat and the second needle seat, the first needle seat being connected with the mounting plate when the second limiting piece of the first needle seat extends into any one of the limiting grooves, and the second needle seat being connected with the mounting plate when the second limiting piece of the second needle seat extends into any one of the limiting grooves.

5. The column system of claim 2, wherein, The mounting plate is further provided with an avoiding hole penetrating along the first direction, which is located between the perfusion through hole and the outflow through hole.

6. The column system of claim 1, wherein, The first section extends out of the third groove at one end away from the second section and is connected with the elastic plug.

7. A generator characterized by The column tube system as claimed in any one of claims 1 to 6 is included in a reaction tank provided with a sealed cavity, and the column tube is located in the sealed cavity.

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