Multi-path extrusion device for selectively extruding flexible pipeline

Abstract

A device for securing a set of M flexible conduits and selectively pressing or releasing all or N sub-conduits, the device comprising: a body (1) having M channels (12) for receiving conduits; a set of pressing elements (4), each pressing element being guided in the guide slot and being radially movable about the main axis A, each pressing element being configured to selectively press or release the conduit; pivoting the selector hub (2) wherein the angular position of the selector hub around the main axis is used to select the N sub-tubes by selecting a subset of the respective pressing elements to be allowed to move; a pivoting control member (3) having a cam portion (32) configured to cause or allow radial movement of the pressing element upon rotation of the control member.

Description

Technical Field

[0001] The present invention relates to a fluid distribution device. More precisely, the present application relates to a multi-channel extrusion device for controlling a biopharmaceutical process, generally a bioprocess system. The present application is particularly applicable to arrangements using disposable components. Background Art

[0002] We are aware of extrusion valves for fluid delivery devices, such as those used on the pipes of disposable liquid handling systems in the bioprocess field.

[0003] Disposable systems generally employ sterilized components that come into contact with the target fluid being processed. Extrusion valves are often used in conjunction with such disposable components due to their simple and cost-effective principle.

[0004] Regarding extrusion valves, there is at least a flexible portion of the pipe, and the extrusion valve acts on the outer wall of this flexible portion. There is also at least an extrusion element, also known as a clamping element. When the extrusion element squeezes the flexible pipe and obstructs the flow of fluid inside the pipe, the valve is in the "closed" state. When the pipe is not squeezed, i.e., not clamped, due to its own elasticity, the pipe returns to its static shape, and here fluid is allowed to flow along the pipe, and at this time the valve is in the "open" state. There is no contact between the extrusion valve and the fluid itself, which helps to maintain the sterility of the fluid.

[0005] WO2020126638 discloses a manifold controlled by a plurality of extrusion valves. However, such a device requires individual control of each extrusion valve, so it has a complex structure and high cost.

[0006] The inventors have attempted to propose a cost-effective solution that controls multiple extrusion valves through a single optimized device. Summary of the Invention

[0007] Therefore, the present invention proposes a device (distribution device) for fixing a set of M flexible pipes and selectively extruding or releasing all or a subset of N sub-pipes among the set of M flexible pipes, the device comprising:

[0008] - a body (1) having at least M channels (12), each channel for accommodating a pipe, the body having a main axis (A),

[0009] - a set of extrusion elements (4), each extrusion element being guided in a guide groove and being radially movable within the channel around the main axis A, each extrusion element being configured to selectively extrude or release a pipe,

[0010] - a selector hub (2) pivotally mounted within the body around the main axis A, wherein the angular position of the selector hub around the main axis selects N sub-pipes by selecting the subset of the corresponding extrusion elements that are to be allowed to move,

[0011] - A control member (3), pivotally mounted within the body about a main axis A, the control member having a cam portion (32) configured to cause or allow radial (outward or inward) movement of some of the squeezing elements when the control member rotates about the main axis.

[0012] - A mechanical coupling arrangement (24, 34) wherein the control member is rotationally coupled to the selector hub to allow free relative rotation over a first angular range and to form a rotationally rigid connection after exceeding this first angular range.

[0013] With this structure, rotation of the selector hub enables it to select the appropriate pipe to be operated, i.e., to change the valve state, while rotation of the control member in either direction causes selective squeezing or release of the said pipe respectively.

[0014] More precisely, rotation of the selector hub enables it to select the subset of the corresponding squeezing elements that are to be allowed to move, corresponding to the subset of sub - pipes.

[0015] In a non - limiting specific example, only one squeezing element and a corresponding pipe are allowed to change state, and the selector hub keeps the other pipes in the current state (squeezed or released). In another non - limiting specific example, the selector hub keeps the other pipes in the current squeezed state and only allows one pipe to be released through the corresponding squeezing element.

[0016] Generally, the number M of channels is at least 2, usually more than 3 or 4.

[0017] It should be understood that each pipe has a valve function, wherein when the pipe is not squeezed, the valve is in the "open" state, and due to its own elasticity, the pipe returns to its rest shape, allowing fluid to flow through the pipe. It should also be understood that at least a part of the pipe in the valve area is flexible, and other parts of the pipe can be rigid. When the pipe is squeezed, the valve is in the "closed" state.

[0018] The distribution device proposed by the present invention is a multi - way distribution device, i.e., an M - way distribution device. As will be described in detail later, this distribution device can prevent cross - contamination between different passages of the multi - way distribution device.

[0019] In various embodiments of the present invention, one or more of the following structures can be employed alone or in combination.

[0020] According to a preferred embodiment, the cam portion (32) is configured to cause radial outward movement of some of the squeezing elements when the control member rotates about the main axis, and in the normal state, the pipes are not pushed by the squeezing elements. When the cam portion does not push the squeezing elements outward, the inherent elasticity of the pipes causes the squeezing elements to be radially inwardly biased.

[0021] According to an alternative, the cam portion is configured to cause a radially inward movement of some of the squeezing elements when the control member rotates about the main axis. In this case, a biasing system is provided to push the squeezing elements radially outward to return to the rest position.

[0022] According to one embodiment, M - N pipes are generally squeezed by the squeezing elements and the selector hub, and the device is configured to release only one or two selectable pipes, i.e., N = 1 or N = 2. In practical applications, according to an example, M is selected in the range of [4 - 12], preferably in the range of [6 - 10].

[0023] According to one aspect, for the M - N pipes that are generally squeezed, the squeezing elements are pushed outward at least by the selector hub. For one or two selectively releasable pipes, the squeezing elements are pushed outward by the control member or allowed to move inward.

[0024] According to one embodiment, the selector hub (2) includes a locking member (58) configured to prevent the selector hub from rotating in a first rotational direction (e.g., clockwise) and to allow the selector hub to rotate in a second rotational direction (e.g., counterclockwise). In other words, the locking member enables the selector to have a one - way rotational movement within the body. Further, when the control member rotates in the first rotational direction (e.g., clockwise), the cam portion (32) causes a radial movement of some of the squeezing elements, i.e., allows them to move inward.

[0025] The locking member can be a pawl or an elastic finger.

[0026] According to one embodiment, the locking member (58) abuts against a shoulder of the body. Embodiments including this embodiment are considered to be easy to implement with the locking member.

[0027] According to one embodiment, the control member includes a manually operable top projection, i.e., operated by the user's finger. Embodiments including this embodiment are considered to have a simple design, high cost - effectiveness, and intuitiveness.

[0028] According to one embodiment, the top projection indicates the position of the pipe for releasing the squeezing action, i.e., opening the squeezing valve, by its orientation or an arrow thereon. Embodiments including this embodiment are considered to provide an intuitive use of the dispensing valve.

[0029] According to one embodiment, the control member rotates through an output shaft controlled by an electric actuator. Thus, we provide an electric valve that can remotely operate the dispensing device.

[0030] Therefore, the present application also relates to an assembly that includes the above - mentioned dispensing device and an electric actuator having an output shaft connected to the dispensing device (see Figure 11 andFigure 17 )。

[0031] According to one embodiment, the first angular range is between 100° and 180°. Embodiments incorporating this embodiment are considered to enable smooth cam actuation with a relatively low inclination of the cam ramp.

[0032] According to one embodiment, the mechanical coupling means causes the control member to include a pin (34) engaged in an arcuate slot (24) provided in the selector hub, and the available angular travel of the pin within the arcuate slot defines the first angular range. Embodiments incorporating this embodiment are considered to form a simple and reliable solution for providing free relative rotation along the first angular range and a rotational drive function beyond this first angular range.

[0033] According to one embodiment, the channels are arranged in a circular pattern and are evenly distributed circumferentially. Embodiments incorporating this embodiment are considered to optimize the space occupied.

[0034] It should be understood that the circumferential arrangement may be different from the evenly distributed arrangement, for example having unequal angular spacings, or only a sector area of less than 360° carrying the channels.

[0035] According to one embodiment, M is at least 4, and the device has at least 4 channels and accommodates at least 4 pipes. Embodiments incorporating this embodiment are considered to be adaptable to a variety of systems in which such a distribution device can be used.

[0036] According to one embodiment, N is equal to 1. Embodiments incorporating this embodiment are considered to provide a state in which all pipes except one are squeezed, and any pipe can be selected for release, thus providing maximum flexibility and selectivity.

[0037] According to one embodiment, the selector hub may include an outer rim (28) interrupted by recesses (26). Embodiments incorporating this embodiment are considered to allow the recesses to permit one or two squeezing elements to move inward.

[0038] According to one embodiment, each channel includes an insertion slot (95). Embodiments incorporating this embodiment are considered to allow the pipes to be very easily inserted into the channels in a radially inward direction. It should be understood that due to the flexibility of the pipes, the size of the insertion slot is much smaller than the outer diameter of the pipes in a stationary state. Therefore, it is not necessary to insert the pipes from the bottom or top of the channels. Thus, in some embodiments, even if both ends of the pipes are continuously connected to other devices, the already connected pipes can be inserted into the channels through the slots.

[0039] According to one embodiment, sensing means (7) are provided to sense the radial position of each squeezing element.

[0040] According to one embodiment, each squeezing element may include a magnet (71) and is provided with a Hall effect sensor (72) which is located opposite the magnet when the squeezing element is pushed radially outwards, i.e., when the pipe is squeezed. This allows for the control of the normal operation and closed-loop control of the squeezing element in an electric configuration.

[0041] According to one embodiment, the Hall effect sensor is mounted on a printed circuit board, i.e., a PCB.

[0042] According to one embodiment, a biasing member (9) is provided to push the squeezing element radially inwards. This complements the elasticity of the pipe.

[0043] According to one embodiment, the front portion of each squeezing element is wedge-shaped.

[0044] This application also relates to an assembly which includes at least two of the above devices and a control shaft controlled by an electric actuator.

[0045] According to a second aspect of the present application, which can be considered independently of the above first aspect, there is provided a device for fixing a set of M flexible pipes and selectively squeezing or releasing all M flexible pipes, the device comprising:

[0046] - a body (1) having M channels (12), each channel for receiving a pipe, the body having an axis A,

[0047] - a set of squeezing elements (4), each squeezing element being guided in a guiding groove and being radially movable within the channel about the axis A, each squeezing element being configured to selectively squeeze or release a pipe,

[0048] - a control member (3) pivotally mounted within the body about the axis A, there being a mechanical interaction between the control member and the squeezing elements to cause a radial movement of all the squeezing elements together when the control member rotates about the axis.

[0049] According to one embodiment, in the above device, the mechanical interaction is formed by a set of linkages (8), where each linkage has a first end (81) and a second end (82), the first end being connected to the rear end of one squeezing element and the second end being connected to an attachment portion of the control member.

[0050] According to one embodiment, the mechanical interaction is formed by one or more cam portions provided on the control member and corresponding cam follower regions on the rear ends of the respective squeezing elements.

[0051] According to one embodiment, the control member has a predetermined angular range within the body, the predetermined angular range having a first angular stop and a second angular stop, wherein when the control member abuts against the first angular stop, the squeezing element completely withdraws from the channel, and wherein, when the control member abuts against the second angular stop, the squeezing element is urged to squeeze the pipe contained in the channel to hinder any fluid flow in the pipe.

[0052] According to one solution, the predetermined angle range between the first angle stop and the second angle stop is between 25° and 50°.

[0053] According to one solution, for each link, the first end is pivotally connected to the rear end of one extrusion element via a first joint axis (X1), and the second end is pivotally connected to the attachment portion of the control member via a second joint axis (X2).

[0054] According to one solution, when the control member abuts against the second angular stop, the main axis A, the first articulation axis and the second articulation axis are substantially aligned for each pair of connecting rod and pressing element.

[0055] According to one solution, for each link, a first pivot pin is provided at the pressing element and a second pivot pin is provided at the control member (3).

[0056] According to one version, each channel comprises an insertion slot (95).

[0057] According to one embodiment, M is at least 4, and the device has at least 4 channels and accommodates at least 4 tubes.

[0058] According to one solution, the control member is rotated by an output shaft controlled by an electric actuator (6). BRIEF DESCRIPTION OF THE DRAWINGS

[0059] Other characteristics and advantages of the invention emerge from the following detailed description of two embodiments given by way of non-limiting examples and with reference to the accompanying drawings.

[0060] Figure 1A A schematic diagram of a bioprocess system involving an apparatus according to an embodiment of the present invention is exemplarily shown.

[0061] Figure 1B A schematic diagram of another type of system involving an apparatus according to an embodiment of the present application is exemplarily shown.

[0062] Figure 2A The pipe in the channel is shown exemplarily in a released state.

[0063] Figure 2B The pipe in the squeezed state in the channel is shown by way of example.

[0064] Figure 3 Shows an exploded perspective view of a dispensing device according to the present application.

[0065] Figure 4 Shows a more detailed view of the control member.

[0066] Figure 5 Shows a more detailed view of the selector hub.

[0067] Figure 6 Shows a more detailed view of the selector hub.

[0068] Figure 7 Shows a bottom view of the selector hub and the control member.

[0069] Figure 8 Shows a cross-sectional view of the selector hub and the control member.

[0070] Figure 9 Shows a perspective cross-sectional view of a device with a biasing tongue according to a variant embodiment.

[0071] Figure 10 Shows a more detailed view of the biasing tongue.

[0072] Figure 11 Shows another embodiment in an electric configuration.

[0073] Figure 12 And Figure 13 Shows another embodiment in which two pipes can be selected simultaneously. Figure 12 Shows the relevant selector hub.

[0074] Figure 13 Shows the relevant cross-sectional view.

[0075] Figure 14 And Figure 15 Shows yet another embodiment having an extrusion element position sensing device. Figure 14 Shows the relevant exploded perspective view. Figure 15 Shows the relevant axial cross-sectional view.

[0076] Figure 16 Schematically shows the states of the dispensing device at different positions from a top view. Figure 16 A shows the first position where the first extrusion element is retracted. Figure 16 B shows the second state where the control member rotates counterclockwise while the selector hub remains stationary. Figure 16 C shows the third state where the control member and the selector hub rotate counterclockwise by an angular range corresponding to the angular pitch of the two extrusion elements. Figure 16D shows a fourth state in which the control member rotates in a clockwise direction while the selector hub does not rotate, thereby allowing another extrusion element to retract.

[0077] Figure 17 Another embodiment is shown in which a plurality of dispensing devices are stacked one above the other and are provided with electric actuators.

[0078] Figure 18 and Figure 19 Yet another embodiment is shown which has a common control of the extrusion elements. Figure 18 A shows a closed position, while Figure 18 B shows an open position. Figure 19 A partial view around the link is shown.

[0079] Figure 20 The guide groove accommodating the extrusion element is shown in more detail. Figure 20 is a sectional view taken along the Figure 9 XX-XX cutting plane shown in. In addition, two extrusion elements are omitted in Figure 20 for clarity. Detailed Description

[0080] In the drawings, the same reference numerals denote the same or similar elements.

[0081] In biopharmaceutical production, disposable systems have emerged and are well suited for liquid handling in biopharmaceutical preparation systems. Such disposable systems use disposable components preferably made of incinerable plastic materials and are generally discarded after use to avoid cleaning and associated cleaning validation prior to reuse. By such disposable systems, we thus avoid using expensive sterilization methods. By sterilizing and manufacturing the disposable components in a clean room, all cleaning and cleaning validation prior to processing are also eliminated.

[0082] Here, we specifically focus on systems using flexible tubing.

[0083] In Figure 1A we schematically present an exemplary bioprocess system involving a dispensing device 10. An input channel 200, such as a flexible tubing, extends from an input port through a first portion 101 of the dispensing device 10 to a first bioreactor 201. The first portion 101 includes a pinch valve. Any target drug product flows in the input channel 200. In the first bioreactor 201, reaction products can be added from an auxiliary container 208. At the output of the first bioreactor 201, the resulting drug product is directed through a second portion 102 of the dispensing device 10 to a second bioreactor 202. The second portion 102 includes a pinch valve. In the second bioreactor 202, reaction products can be added from an auxiliary container.

[0084] At the output of the second bioreactor 202, the resulting pharmaceutical product is guided through the third part 103 of the dispensing device 10 to the third bioreactor 203. In the third bioreactor 203, reaction products can be added from an auxiliary container.

[0085] At the output of the third bioreactor 203, the resulting pharmaceutical product is guided through the fourth part 104 of the dispensing device 10 to the fourth bioreactor 204. In the fourth bioreactor 204, reaction products can be added from an auxiliary container.

[0086] At the output of the fourth bioreactor 204, the resulting pharmaceutical product is guided through the fifth part 105 of the dispensing device 10 to the output port 209.

[0087] The bioreactors 201 - 204 can for example be made of plastic. The bioreactors 201 - 204 can be disposable devices. The individual parts 101 - 105, for example as separate pinch valves, are arranged in a single unit, herein called the "dispensing device" 10, as described below.

[0088] Although the separate pinch valves are arranged in the dispensing device of a single unit, it should be noted that each separate valve is physically independent of the others. Thus, cross - contamination between the pinch valves is not possible, nor is cross - contamination between the flexible pipes, let alone between the pharmaceutical products flowing into these pipes.

[0089] Of course, the number of bioreactors arranged in series can be more, or conversely less.

[0090] It is important to note that in the above arrangement, the successive parts 101 - 105 of the dispensing device 10 are opened one after the other in sequence. Each part can be formed as a pinch valve. In this case, each part is selectively opened to allow the pharmaceutical product to pass through, while the other parts remain closed. Each bioreactor is activated after its previous one and before its next one. In such a system, a pumping device (not shown) can be provided. We note that the system can include a pumping device (not shown).

[0091] In Figure 1B a further configuration is presented in which the dispensing device according to the present application can be used. In this schematically depicted configuration, a large container 300 contains a quantity of pharmaceutical product that is to be dispensed into smaller container / containers 310. The number and volume of the container / containers are not limited in themselves. It can be as small as a single vaccine dose.

[0092] In this case, the dispensing device comprises one or more parallel channels, each controlled by a pinch valve. The pinch valves can be activated together, in a simultaneous manner, or alternatively, each pinch valve can be selectively activated.

[0093] In the following text, the quantity M represents the number of channels, which is also the number of channels used in the dispensing device 10. In some applications, some of the available channels may not have any tubes.

[0094] Figure 2A The flexible tube 5 within the channel is shown exemplarily in cross-section. In this case, the squeezing element 4 does not interfere with the tube 5. Flow of the product within the tube is possible. In other words, the tube within the channel is released. The state of the squeezing valve is also referred to as "open".

[0095] In contrast, Figure 2B The squeezed tube within the channel 12 is shown exemplarily in cross-section. In this case, the squeezing element 4 interferes with the tube 5. The squeezing element 4 radially squeezes the tube. There is no remaining cross-section at this position to allow liquid to flow along the tube 5. The squeezing element 4 is selectively movable radially inwards or outwards. The front end of the squeezing element is preferably smooth and rounded to provide a tight contact with the squeezed tube. In some embodiments, the front end of the squeezing element may present an arc shape. The state of the squeezing valve is also referred to as "closed". In other words, the flow of liquid within the tube is impeded.

[0096] The slot 95 allows the flexible tube to be inserted into the channel and allows the flexible tube to be removed from the channel after use. Due to the small width of the slot, once the flexible tube is within the channel, it cannot be removed unless intentionally squeezed. We also note that when the squeezing element 4 presses against the flexible tube, there is a tendency to move the tube away from the slot 95. Thus, the risk of the tube accidentally detaching from the channel 12 is alleviated or even eliminated.

[0097] In the absence of interaction with the squeezing element, the inherent elasticity of the flexible tube biases the tube into a circular rest configuration, occupying most of the available cross-sectional area of the channel 12.

[0098] Figure 3 An exploded perspective view of the dispensing device 10 according to the present application is shown. Figure 4 - Figure 8 An additional view including details is provided.

[0099] The dispensing device 10 includes a body 1. The body is made of molded plastic.

[0100] The dispensing device 10 includes a selector hub 2, which is pivotally mounted within the body 1 about the main axis A. The selector hub 2 includes a cylindrical outer journal bearing interface 23, which is received within a corresponding inner bearing 13 of the body 1. The selector hub 2 includes an outer rim 28, which is designed to push the squeezing element 4 outwards.

[0101] The selector hub 2 includes a cylindrical inner journal bearing 20 to receive the shaft portion of a control member to be discussed later.

[0102] The selector hub 2 includes an arcuate groove 24. The bending center line L24 of the arcuate groove 24 follows a circular arc centered on the device axis A.

[0103] The body includes a plurality of channels 12, each channel being configured to receive / accommodate a flexible pipe 5 to be selectively squeezed by the device. In one embodiment, each channel is formed with an insertion slot 95 as shown in Figure 2A and Figure 2B . However, it is not excluded that the channels have no insertion slots as shown in Figure 11 .

[0104] In addition, as shown in the various figures, the cross-section of the channel 12 can be circular or square. Other cross-sectional shapes are not excluded either.

[0105] The body 1 includes a plurality of guide grooves 21, which will be discussed later. Each guide groove 21 includes side walls 22 integrally formed with the body 1. Each guide groove provides a sliding means for the squeezing element received therein.

[0106] The dispensing device 10 includes a set of squeezing elements 4, each squeezing element involving a squeezing valve portion.

[0107] Each squeezing element is movable and is guided in the guide groove 21 in a radial direction around the main axis A. As Figure 20 shown, the guide groove includes two spaced parallel walls 211, 212. The width of the squeezing element 4 is slightly less than the distance separating the two walls 211, 212.

[0108] Each squeezing element has a front end 41 that can extend into the channel. The front end 41 is movable into and out of the channel, whereby each squeezing element 4 is configured to selectively squeeze or release a pipe. Each squeezing element has a rear end 44 that is configured to contact the outer rim 28 of the selector hub 2, or the cam portion 32 of the control member, or both. Each squeezing element 4 includes side walls 46 adapted to slide within the walls 22 of the guide groove 21. The outer rim 28 is interrupted at least at one position where it does not prevent the squeezing element from retracting towards the main axis A. A recess 26 is formed here.

[0109] As Figure 9 shown on the left, the flexible pipe 5 is not squeezed, while in contrast, the squeezing element 4 on the right is pushed outwards and squeezes the flexible pipe 5.

[0110] In the example shown, there are eight guiding grooves 21, eight pressing elements 4, and eight channels 12. Each group (channel + pressing element + guiding groove + the pipe therein) forms an independent extrusion valve. Each independent extrusion valve is completely separated from another independent extrusion valve: this ensures avoiding any cross - contamination between the independent extrusion valves.

[0111] However, the number M of channels, guiding grooves, and pressing elements can be less, for example, from 2 to 7, or can be more, for example, 10 or 12, without excluding any other values.

[0112] Returning to the example with eight independent extrusion valves, that is, eight (channel + pressing element + guiding groove), they are evenly distributed along the circumference, that is, each extrusion valve is spaced 45°.

[0113] For another embodiment with 6 extrusion valves, they will be distributed every 60°. For another embodiment with 10 extrusion valves, they will be distributed every 36°. Non - uniform distribution along the circumference is not excluded.

[0114] The dispensing device 10 includes a control member 3. The control member 3 is pivotally mounted in the body about an axis A.

[0115] The control member 3 includes a shaft 30 that extends along the main axis into a cylindrical inner journal bearing 20 of the selector hub 2.

[0116] The control member 3 includes an outer rim 35 that is received in a cylindrical bearing 15 of the body. The control member 3 includes an upper outer edge 38 that is pivotally mounted in an upper inner edge 16 of the body 1.

[0117] The control member includes a cam portion 32 that is configured to cause or allow a radial movement of the pressing element when the control member rotates about the main axis. In the example shown, the cam portion 32 pushes the pressing element outward. In an alternative configuration not shown, the cam portion 32 can pull the pressing element in an inward direction.

[0118] The control member 3 includes a drive pin 34 that extends in a direction parallel to the main axis A. The drive pin 34 is received in an arcuate slot 24 of the selector hub 2. The drive pin 34 can move freely along the arcuate slot 24. The length of the arcuate slot, that is, the angular aperture, defines the length of the free range. The angular aperture corresponding to the said free clearance is herein called the "first angular range".

[0119] The arcuate slot is defined at its two ends by a first abutment 241 and a second abutment 242. In the clockwise direction CW, the drive pin 34 abuts against the first abutment 241, while in the counter - clockwise direction CC, the drive pin 34 abuts against the second abutment 242.

[0120] The dispensing device 10 includes a sealing washer 92 which is arranged at the bottom part 19 of the body, and this bottom part is generally opposite to the upper surface of the control member 3 in the overall assembly. The washer 92 is adjacent to the bottom plane 19 of the body 1. In the illustrated example, the shaft 30 of the control member is received in the central hole 93 of the washer 92.

[0121] It should be understood that in the illustrated example, the control member 3 and the washer 92 sandwich the selector hub 2 within the body. It should be noted that the corresponding fastening means are not shown in the drawings.

[0122] Now turning to Figure 4 a one-way rotation system is provided to allow the selector hub to rotate in the counterclockwise direction and prevent the selector hub from rotating in the clockwise direction.

[0123] More precisely, in this example, a leaf spring 58 is arranged in the slot 57. The leaf spring slot 57 extends substantially tangentially.

[0124] The free end 58a of the spring abuts against a shoulder 18 provided on the outer journal bearing interface 23 of the body. When the selector hub rotates in the counterclockwise direction, the leaf spring 58 bends and passes over the shoulder 18. Conversely, when the selector hub rotates in the clockwise direction, the free end 58a of the spring abuts against the shoulder 18, thus preventing further rotational movement.

[0125] It should be understood that a drive pin can be arranged on the selector hub 2 and an arcuate slot can be arranged on the control member, corresponding to the inverted configuration shown above. In addition, any other drive mechanism with a large angular free clearance can also be considered.

[0126] Therefore, the present application covers any mechanical coupling device in which the control member is rotationally coupled to the selector hub to allow free relative rotation within a first angular range and form a rotationally rigid engagement after exceeding this first angular range. We note that infinite rotation of the selector hub in the clockwise direction CW is possible.

[0127] In the illustrated example, the recess 26 provided in the outer rim 28 only covers the angular range E6 of one extrusion element. Except for the position of this recess, the outer ring 28 holds all the extrusion elements 4 in the outwardly pushed position. Only the extrusion element located opposite the recess 26 can move radially inwards. In this case, N = 1.

[0128] From Figure 9 it is obvious from the right side that the lower rear end 442 of the extrusion element interferes with the outer rim 2 of the selector hub 2. The upper rear end 441 of the extrusion element interferes with the cam portion 32 of the control member 3.

[0129] Now turning to Figure 16, where the perspective is from the top region, clockwise is denoted as CW, and counterclockwise is denoted as CC. Generally, we can use the terms "first rotation direction" and "second rotation direction" without referring to the clock.

[0130] During Figure 16 In the process shown in A - 16D, the body 1 remains stationary, and the guide groove also remains stationary.

[0131] Figure 16 The state shown in A shows a squeezing element retracted (reference 401), i.e., a pipe is released (the squeezing valve is open). The other squeezing elements 402, 403 are held in the outward position by the outer rim 28 of the selector hub. It should be noted that in Figure 16 A, the control member is not shown.

[0132] During Figure 16 In B, the selector hub 2 is in the same position as Figure 16 A, and the control member 3 has been rotated 180° counterclockwise. During this rotation, the cam member has gradually pushed the squeezing element 401 outward. Thus, the flexible pipe located in front of this squeezing element 401 is squeezed, and the channel is closed.

[0133] The angular length of L24 is consistent with the angular length of the cam slope. It can be any value in the range of 45° - 315°. In an exemplary configuration, the angular length of the cam slope can be between 90° and 270°. In the shown example, the angular length of the cam slope is approximately 180°. Generally, we can select the first angle range to be between 100° and 180°.

[0134] During Figure 16 In C, the control element 3 further rotates counterclockwise CC together with the selector hub. More precisely, the drive pin 34 abuts against the end abutment 241 of the arcuate groove 24, so the drive pin 34 drives the selector hub 2 counterclockwise along with the control member 3.

[0135] In the shown example, the counterclockwise rotation has an angular range corresponding to the angular pitch of two squeezing elements. Here, there are 8 channels evenly distributed in the circumferential direction, and the angular range corresponding to two squeezing elements is 90°. Otherwise, the center line L0 of the recess rotates 90° counterclockwise. All squeezing elements are held in the outward position, the squeezing element reference 403 is pushed by the cam part 32, and the other squeezing elements are pushed outward by the outer rim 28 of the selector 2.

[0136] During Figure 16In D, the control element has been rotated 180° clockwise (CW). However, the extrusion element is allowed to move inwards towards the axis with reference to 403. Thereby, the channel in front of the extrusion element 403 is released. Due to the above-mentioned one-way rotation system, there is no possibility or risk of moving the selector hub counterclockwise.

[0137] From FIGS. 1 and Figure 9 it is obvious that the top side of the control member 3 includes a knob 39 to allow the user to easily operate it by hand. Additionally, according to an advantageous embodiment, the knob can be an upright protrusion. Such a top protrusion can be manually operated, i.e., by the user's finger.

[0138] In the illustrated example, according to Figure 1A the overall configuration shown, the knob is aligned with the selection of the channel to be released. This provides an intuitive positioning indication for the user.

[0139] Biasing spring

[0140] As Figure 9 and Figure 10 shown, in addition to the features already disclosed, a biasing spring 9 can be provided. Each extrusion element is provided with a biasing spring.

[0141] Each biasing spring includes a base 90, an elastic intermediate portion 91, and a pusher portion 96. The base 90 is fixedly secured to the body, for example, by a recessed notch 17. The base 90 is held in position within the notch by the control member 3 closing the notch inwards.

[0142] The pusher portion 96 is received within a recess 94 provided in the respective extrusion element. The pusher portion 96 preferably has a convex shape. As the elastic intermediate portion bends, the pusher portion 96 moves substantially inwards or outwards.

[0143] Each biasing spring 9 can be made from a metal blank or as a molded plastic part. Each biasing spring 9 pushes the extrusion element inwards.

[0144] Depending on the nature and elasticity of the flexible pipe, the biasing spring 9 exerts a strong and predictable force to reliably release the flexible pipe when in the state where each valve needs to be opened. In this case, the pipe does not need to be pushed back against the extrusion element. The elasticity of the pipe only restores its rest geometry.

[0145] The rest position is as Figure 9 shown on the left, and the deflected position is as Figure 9 shown on the right.

[0146] Motor assisted rotation

[0147] As Figure 11As shown, in addition to the manual operation of the control member, an electric rotation of the control member can also be provided. A motor 6 is provided, which includes a rotor that is rotationally rigid with the shaft 30 of the control member. The motor 6 can be controlled in two rotational directions.

[0148] The dispensing device can be actuated manually or by the motor 6. In the shown configuration, the motor is controlled via an electric wire 61.

[0149] An angle encoder or an angle reference 0 position can be provided to facilitate reliable control from the applied motor.

[0150] Other components provided in the dispensing device are not described further, as they are similar or identical to the components already disclosed for the first embodiment.

[0151] Larger recess

[0152] Figure 12 and Figure 13 A variant is shown, in which the recess 260 provided in the outer rim 28 extends beyond the angular range covering the two extrusion elements. The angular range E62 is 90° here.

[0153] The extrusion elements with references 408, 409 can move inwardly within the recess 260. The other extrusion elements are held in the outward position by the outer rim 28. In this case, N = 2.

[0154] In this variant, depending on the shape of the inclined surface of the control member, the two extrusion valves can be opened simultaneously.

[0155] Other components provided in the dispensing device are not described further, as they are similar or identical to the components already disclosed for the first embodiment.

[0156] Sensing element

[0157] As Figure 14 and Figure 15 As shown, a sensing device 7 can also be provided to sense the actual position of each extrusion element 4.

[0158] For each extrusion element 4, a magnet 71 is accommodated in the bottom region of the extrusion element 4. When the extrusion element is in the outward position, a Hall effect sensor 72 is arranged opposite the magnet. Thus, this position is actively detected as the outward position corresponding to the closed state of the respective extrusion valve.

[0159] A printed circuit board 74 is provided to support the Hall effect sensor 72.

[0160] The sensing device 7 allows for closed-loop control in the case where dispensing is controlled via the motor 6 by the control unit.

[0161] A central Hall effect sensor 75 and a central magnet 76 are also provided. The purpose is to be able to check the correct assembly of the dispensing device.

[0162] Other components provided in the dispensing device will not be described further, as they are similar or identical to the components already disclosed for the first embodiment.

[0163] Device stack

[0164] As Figure 17 shown, consider an assembly consisting of two or more dispensing devices, which has a common central axis 31. The central axis can be made integral with the local axis 30 of each dispensing device. Alternatively, the central axis can be independent, but rotationally rigidly connected to the local axis 30 of each dispensing device.

[0165] In the variant shown, a motor 6 is provided to drive the central axis 31. However, when the top dispensing device includes a control knob as described above, the axis can be manually controlled.

[0166] A plurality of devices are stacked one above the other. The axes of the devices are rotationally rigidly connected to each other. The devices may not be adjacent to each other, and a gap may be provided between two devices. This intermediate gap can be used to provide sufficient space for the pipes to enter and exit their respective channels 12.

[0167] Other components provided in the dispensing device will not be described further, as they are similar or identical to the components already disclosed for the first embodiment.

[0168] Collective control

[0169] As Figure 18 and Figure 19 shown, in this further embodiment, all the extrusion elements 4 are controlled in the same way by the rotation of the control member 3.

[0170] In this embodiment, the selector wheel is not necessary and can be omitted. Only the control member 3 rotates within the body 1 about the axis A. As described in the first embodiment, the extrusion elements are slidably received in the guide grooves.

[0171] The mechanical interaction between the control member 3 and the extrusion elements 4 is formed by a set of linkages 8. Each linkage 8 includes a first end 81 connected to the rear end of one extrusion element and a second end 82 connected to the attachment portion of the control member.

[0172] A first pivot pin 84 is provided at the extrusion element. Here, the first pivot pin and the connecting eyelet form a first joint axis X1.

[0173] A second pivot pin 83 is provided at the control member 3. Here, the second pivot pin and another connecting eyelet form a second joint axis X2.

[0174] The control member 3 can rotate within a predetermined angular range about the axis A. In the example where M = 8, the predetermined angular range is approximately 40°.

[0175] In one embodiment, the predetermined angular range is between a first angular stop and a second angular stop.

[0176] When the control member abuts against the first angular stop, the extrusion element completely exits from the channel, as Figure 18 shown in B.

[0177] When the control member abuts against the second angular stop, the extrusion element is urged to squeeze the pipe accommodated in the channel to impede any fluid flow within the pipe, as Figure 18 shown in A.

[0178] Generally, the predetermined angular range can be between 25° and 50°.

[0179] When the control member abuts against the second angular stop, the main axis A, the first joint axis, and the second joint axis are substantially aligned for each pair of linkages and the extrusion element.

[0180] In this embodiment, the control member 3 can be rotated manually or by an output shaft controlled by an electric actuator 6.

[0181] Generally speaking, the control member allows a mechanical interaction between the control member and the extrusion element so that a radial movement of all the extrusion elements together is caused when the control member rotates about the axis.

[0182] Other

[0183] It should be understood that the features elaborated for any one embodiment can be combined with the features of any other embodiment described herein.

[0184] Relative terms such as "below", "above", "upper", "lower", "horizontal", "vertical", etc. may be used herein to describe the relationship of one element to another element shown in the drawings. It should be understood that these terms and the above terms are intended to cover different orientations of the device in addition to the orientation shown in the drawings. It should be understood that when an element is referred to as "connected" or "coupled" to another element, it can be directly connected or coupled to the other element, or there may be intermediate elements. Conversely, when an element is referred to as "directly connected" or "directly coupled" to another element, there are no intermediate elements.

[0185] Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It should also be understood that the terms used herein should be interpreted as having a meaning consistent with their meaning in this specification and the relevant art, and should not be interpreted in an idealized or overly formal sense unless explicitly so defined herein.

[0186] It should be understood that this application is not limited to the aspects and contents shown in the above aspects and drawings; on the contrary, those skilled in the art will recognize that many changes and modifications can be made within the scope of this application and the appended claims. In the drawings and the specification, the aspects have been disclosed for illustrative purposes rather than limiting purposes, and the scope of the inventive concept is set forth in the appended claims.

Claims

1. An apparatus for fixing a set of M flexible pipes and selectively squeezing or releasing all or N sub - pipes of the set of M flexible pipes, the apparatus comprising: A body (1) having M channels (12), each channel being configured to receive a pipe, the body having a main axis (A); A set of squeezing elements (4), each squeezing element being guided in a guiding groove and being radially movable within the channel about the main axis, each squeezing element being configured to selectively squeeze or release a pipe; A selector hub (2) pivotally mounted within the body about the main axis (A), wherein the angular position of the selector hub about the main axis selects N sub - pipes by selecting a corresponding subset of the squeezing elements to be allowed to move; A control member (3) pivotally mounted within the body about the main axis (A), the control member having a cam portion (32) configured to cause or allow radial movement of some of the squeezing elements when the control member rotates about the main axis; and Mechanical coupling means (24, 34), wherein the control member is rotationally coupled to the selector hub to allow free relative rotation along a first angular range and to form a rotationally rigid connection after exceeding the first angular range.

2. The device according to claim 1, characterized in that, M - N pipes are normally squeezed by the squeezing elements and the selector hub, and the configuration is to release only one or two selectable pipes, i.e., N = 1 or N = 2.

3. The device according to any one of claims 1 to 2, characterized in that The selector hub (2) includes a locking member (28) configured to prevent the selector hub from rotating in a first rotational direction and to allow the selector hub to rotate in a second rotational direction, and wherein when the control member rotates in the first rotational direction, the cam portion (32) causes radial movement of some of the squeezing elements.

4. The device according to any one of claims 1 to 3, characterized in that The control member includes a manually operable top projection (39), i.e., operated by a user's finger.

5. The device according to any one of claims 1 to 3, characterized in that, The control member is rotated by an output shaft controlled by an electric actuator (6).

6. The device according to any one of claims 1 to 5, characterized in that, The first angular range is between 100° and 180°.

7. The device according to any one of claims 1 to 6, characterized in that, The mechanical coupling means causes the control member to include a pin (34) engaged in an arcuate slot (24) provided in the selector hub, and the available angular travel of the pin within the arcuate slot defines the first angular range.

8. The device according to any one of claims 1 to 7, characterized in that, The channels are arranged in a circular pattern and are evenly distributed circumferentially.

9. The device according to any one of claims 1 to 8, characterized in that M is at least 4, and the apparatus has at least four channels and accommodates at least four pipes.

10. The device according to any one of claims 1 to 9, characterized in that, The selector hub includes an outer rim (28) interrupted by recesses (26).

11. The device according to any one of claims 1 to 10, characterized in that, Each channel includes an insertion slot (95).

12. The device according to any one of claims 1 to 11, characterized in that, The apparatus is provided with sensing means (7) to sense the radial position of each squeezing element.

13. The device according to any one of claims 1 to 12, characterized in that, Each squeezing element includes a magnet (71), and the apparatus is provided with a Hall effect sensor (72) which is located opposite the magnet when the squeezing element is radially pushed outwards, i.e., when the pipe is squeezed.

14. The device according to any one of claims 1 to 13, characterized in that, The apparatus is provided with a biasing member (9) to radially push the squeezing elements inwards.

15. A component, which comprises at least two devices according to any one of the preceding claims and a control shaft controlled by an electric actuator.

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