Granulator for pharmaceutical production

Abstract

The invention relates to the technical field of medicine production granulation, and provides a granulator for medicine production, which comprises an outer cylinder, a shell is arranged in the outer cylinder, a flow guide assembly is arranged between the outer cylinder and the shell, a control box is mounted in the lower end of the shell, a heating pipe for drying is mounted on the upper side of the control box, and the upper side of the control box is provided with a water inlet and a water outlet. The lower side of the control box is fixedly connected with a base used for supporting the device, a wind power assembly is arranged in the middle of the control box, a groove is formed in the outer side of the upper end of the outer cylinder, and the rear side of the upper end of the outer cylinder is fixedly connected with an L-shaped plate. A second motor drives a horizontal gear to rotate, the horizontal gear is matched with a gear ring, a rotating ring and a spiral blade are made to rotate, the falling time of particles is prolonged through the spiral blade, the spiral blade is matched with a control box and a heating pipe, the particles are dried, the particles are dried in the falling process, and the situation that subsequent drying is not in time, particles are bonded, and the quality of the particles is affected is avoided.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical production granulation, and specifically to a granulator for pharmaceutical production. Background Art

[0002] Pharmaceutical production refers to the process of processing raw materials into pharmaceuticals for medical use. The process of pharmaceutical production can generally be divided into the raw material drug production stage and the preparation production stage of making the raw material drug into a certain dosage form. In the process of making the raw material drug into a certain dosage form in the preparation production stage, a granulator is usually used, which is used in industries such as pharmaceuticals, food, extracts, chemicals, and solid beverages to make the stirred materials into required granules. It is especially suitable for materials with relatively high viscosity, grinding wet powder raw materials into granules, and can also be widely used for crushing lumps into ready-made granules.

[0003] In the prior art, the commonly used rotary granulator forms granules by extruding raw materials through a sieve mesh, with high efficiency. However, the rotary granulator can only granulate and cannot dry. The formed granules are collected and then dried subsequently. During the collection process, it is easy to cause granule accumulation. The just-formed granules have a relatively high humidity, and long-term accumulation is likely to cause granule adhesion. Subsequent drying requires dispersion, and the dispersion process will cause granule crushing. Moreover, the sieve mesh used for granulation is cumbersome to disassemble. Summary of the Invention

[0004] Aiming at the deficiencies of the prior art, the present invention provides a granulator for pharmaceutical production, which solves the problems that the rotary granulator can only granulate and cannot dry, resulting in untimely subsequent drying, drug granule accumulation, and caking.

[0005] To achieve the above object, the present invention is realized by the following technical solutions: A granulator for pharmaceutical production, comprising an outer cylinder, a housing is arranged inside the outer cylinder, a diversion assembly is arranged between the outer cylinder and the housing, a control box is installed inside the lower end of the housing, a heating pipe for drying is installed on the upper side of the control box, a base for supporting the device is fixedly connected to the lower side of the control box, a wind power assembly is arranged in the middle of the control box, a groove is arranged on the outer side of the upper end of the outer cylinder, an L-shaped plate is fixedly connected to the rear side of the upper end of the outer cylinder, an electric push rod is installed inside the L-shaped plate, a connecting plate is fixedly connected to the driving end of the electric push rod, a hopper is fixedly connected to the end of the connecting plate, a connecting ring is fixedly connected to the outside of the lower end of the hopper, a granulating plate for granulation is fixedly connected to the lower end of the connecting ring, the lower end of the granulating plate is embedded inside the groove, a top plate is fixedly connected to the top of the hopper, a sleeve is rotatably connected to the middle of the top plate, a rotating shaft is rotatably connected inside the sleeve, a material pushing plate is fixedly connected to the lower end of the sleeve, a hexagonal prism is fixedly connected to the bottom of the rotating shaft, an impeller is arranged outside the hexagonal prism, the lower end of the impeller is in close contact with the upper side of the outer cylinder, and the end of the impeller is in close contact with the inside of the granulating plate.

[0006] Preferably, a protective cover is fixedly connected to the upper side of the top plate, a first motor is fixedly connected to the rear side of the protective cover, and the driving end of the first motor penetrates through the rear side of the protective cover and is fixedly connected to a driving bevel gear.

[0007] Preferably, driven bevel gears are meshed and connected to both the upper and lower sides of the driving bevel gear. The driven bevel gear on the upper side of the driving bevel gear is fixedly connected to the outside of the upper end of the rotating shaft, and the driven bevel gear on the lower side of the driving bevel gear is fixedly connected to the outside of the upper end of the sleeve.

[0008] Preferably, the diversion assembly includes a rotating ring rotatably connected to the inner side of the upper end of the outer cylinder. A plurality of spiral blades are fixedly connected to the lower side of the rotating ring. The outside of the spiral blades is in close contact with the inside of the outer cylinder, the inside of the spiral blades is in close contact with the outer wall of the housing, a second scraper is fixedly connected to the upper end of the spiral blades inside the rotating ring, and the outer wall of the second scraper is in close contact with the outer wall of the granulating plate.

[0009] Preferably, a second motor is installed at the lower end of the L-shaped plate. The driving end of the second motor is fixedly connected to a flat gear, and the flat gear is meshed and connected to a toothed ring on the outside. The lower end of the toothed ring is fixedly connected to the top of the rotating ring.

[0010] Preferably, a diversion plate is fixedly connected to the outside of the lower end of the housing. The lower end of the diversion plate is fixedly connected to the inside of the lower end of the outer cylinder. A discharge plate is arranged on the upper side of the diversion plate. The upper end of the discharge plate is fixedly connected to the lower end of the spiral blade. An outlet is arranged on the front side of the lower end of the outer cylinder.

[0011] Preferably, the wind power assembly includes a rotating cylinder rotatably connected to the middle of the control box. A plurality of fan blades are fixedly connected to the outer wall of the rotating cylinder. An opening is provided between the plurality of fan blades on the outside of the rotating cylinder. An air inlet for air intake is provided at the bottom of the rotating cylinder. A hexagonal groove is provided in the middle of the upper end of the rotating cylinder.

[0012] Preferably, a through hole is provided in the middle of the upper end of the outer cylinder above the hexagonal groove. The lower end of the hexagonal prism passes through the through hole and is inserted into the hexagonal groove.

[0013] Working principle:

[0014] Inject the raw materials into the hopper from the top of the device. Start the first motor provided to drive the driving bevel gear to rotate. The rotating driving bevel gear drives the sleeve and the rotating shaft to rotate respectively through the driven bevel gear. The rotating sleeve drives the material distributing plate to rotate, applying a downward pressure to the raw materials. The rotating shaft drives the impeller to rotate through the hexagonal prism. The rotating impeller applies an outward thrust to the raw materials, causing them to be extruded from the holes of the granulation plate.

[0015] Start the second motor provided to drive the spur gear to rotate. The rotating spur gear cooperates with the toothed ring to drive the rotating ring and the spiral blade to rotate. The rotating spiral blade drives the discharge plate and the second scraper to rotate. The rotating second scraper can scrape off the raw materials extruded from the granulation plate, causing them to form particles and fall on the spiral blade, and flow through the spiral blade to the guide plate at the bottom of the outer cylinder. During this process, the control box controls the heating tube to heat and dry the particles. The rotating discharge plate can discharge the dried particles from the discharge port.

[0016] The provided electric push rod can drive the hopper to rise through the connecting plate, thereby driving the sleeve and the rotating shaft to rise. At this time, the granulation plate can be driven to rise. At the same time, the hexagonal prism is driven to rise through the rotating shaft and separated from the impeller, exposing the impeller on the upper side of the outer cylinder, facilitating cleaning. At the same time, the connecting ring and the granulation plate can be replaced. After replacement, the electric push rod drives the hopper to descend, and at the same time drives the hexagonal prism to insert into the middle of the impeller. The lower end of the hexagonal prism passes through the bottom of the impeller and passes through the through hole and inserts into the hexagonal groove. When it rotates, it drives the rotating cylinder to rotate, thereby driving the fan blades to rotate, promoting air flow to form an air current. The air current blows towards the heating tube, causing the heat to pass through the holes at the upper end of the housing and dry the particles on the spiral blade.

[0017] The present invention provides a granulator for pharmaceutical production. It has the following beneficial effects:

[0018] 1. In the present invention, the second motor drives the spur gear to rotate and cooperate with the toothed ring, so that the rotating ring and the spiral blade rotate. The spiral blade increases the falling time of the particles and cooperates with the control box and the heating tube to dry the particles, enabling the particles to be dried during the falling process, avoiding subsequent untimely drying, resulting in particle adhesion and affecting the quality of the particles.

[0019] 2. While the hexagonal prism drives the impeller to rotate for granulation, the present invention drives the rotating cylinder and fan blade arranged below to rotate, forming an air flow, promoting the dissipation of heat from the heating tube, and improving the drying effect.

[0020] 2. The electric push rod provided in the present invention can drive the hopper and the granulation plate to rise, separating the granulation plate from the outer cylinder, facilitating the disassembly and replacement of the granulation plate. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 is a perspective view of the present invention;

[0022] Figure 2 is a schematic diagram of the spiral blade of the present invention;

[0023] Figure 3 is a schematic diagram of the housing of the present invention;

[0024] Figure 4 is a schematic diagram of the heating tube of the present invention;

[0025] Figure 5 is a schematic diagram of the rotating cylinder of the present invention;

[0026] Figure 6 is a schematic diagram of the impeller of the present invention;

[0027] Figure 7 is a schematic diagram of the rotating shaft of the present invention;

[0028] Figure 8 is a schematic diagram of the protective cover of the present invention.

[0029] Among them, 1. Outer cylinder; 2. Housing; 3. L-shaped plate; 4. Connecting plate; 5. Hopper; 6. Connecting ring; 7. Granulation plate; 8. Groove; 9. Top plate; 10. Sleeve; 11. Rotating shaft; 12. Feeding plate; 13. Impeller; 14. Hexagonal prism; 15. Protective cover; 16. First motor; 17. Driving bevel gear; 18. Driven bevel gear; 19. Rotating ring; 20. Tooth ring; 21. Spiral blade; 22. Second motor; 23. Flat gear; 24. Deflector; 25. Discharge plate; 26. Discharge port; 27. Base; 28. Control box; 29. Heating tube; 30. Rotating cylinder; 31. Fan blade; 32. Opening; 33. Hexagonal groove; 34. Through hole; 35. Electric push rod; 36. Second scraper. DETAILED DESCRIPTION OF THE INVENTION

[0030] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0031] Embodiment:

[0032] Please refer to the attached Figure 1 - attached Figure 8 , the present invention provides a granulator for pharmaceutical production, including an outer cylinder 1. Inside the outer cylinder 1, there is a housing 2. Inside the lower end of the housing 2, there is a control box 28. Above the control box 28, there is a heating pipe 29 for drying. Below the control box 28, there is a base 27 for supporting the device. On the outer side of the upper end of the outer cylinder 1, there is a groove 8. At the rear side of the upper end of the outer cylinder 1, there is an L-shaped plate 3 fixedly connected. Inside the L-shaped plate 3, there is an electric push rod 35. The driving end of the electric push rod 35 is fixedly connected to a connecting plate 4. At the end of the connecting plate 4, there is a hopper 5 fixedly connected. Outside the lower end of the hopper 5, there is a connecting ring 6 fixedly connected. At the lower end of the connecting ring 6, there is a granulating plate 7 for granulation. The lower end of the granulating plate 7 is embedded inside the groove 8. At the top of the hopper 5, there is a top plate 9 fixedly connected. In the middle of the top plate 9, there is a sleeve 10 rotatably connected. Inside the sleeve 10, there is a rotating shaft 11 rotatably connected. At the lower end of the sleeve 10, there is a feeding plate 12 fixedly connected. At the bottom of the rotating shaft 11, there is a hexagonal prism 14 fixedly connected. Outside the hexagonal prism 14, there is an impeller 13. The lower end of the impeller 13 is in close contact with the upper side of the outer cylinder 1. The end of the impeller 13 is in close contact with the inside of the granulating plate 7. Above the top plate 9, there is a protective cover 15 fixedly connected. At the rear side of the protective cover 15, there is a first motor 16 fixedly connected. The driving end of the first motor 16 penetrates through the rear side of the protective cover 15 and is fixedly connected to a driving bevel gear 17. On both the upper and lower sides of the driving bevel gear 17, there are driven bevel gears 18 meshingly connected. The driven bevel gear 18 above the driving bevel gear 17 is fixedly connected to the outside of the upper end of the rotating shaft 11. The driven bevel gear 18 below the driving bevel gear 17 is fixedly connected to the outside of the upper end of the sleeve 10.

[0033] The raw materials are fed into the hopper 5 from the top of the device. At the same time, the first motor 16 and the control box 28 are started. The first motor 16 drives the driving bevel gear 17 to rotate. The rotating driving bevel gear 17 drives the sleeve 10 and the rotating shaft 11 to rotate respectively through the driven bevel gear 18. The rotating sleeve 10 drives the material distributing plate 12 to rotate. The inclined setting of the material distributing plate 12 can apply a downward pressure on the raw materials, making them fall into the gaps of the impeller 13. The rotating shaft 11 drives the impeller 13 to rotate through the hexagonal prism 14. The rotating impeller 13 applies an outward thrust on the raw materials, making them extrude from the holes of the granulation plate 7. The extruded raw materials form particles and fall between the outer cylinder 1 and the housing 2. The control box 28 and the heating pipe 29 heat and dry the particles through the ventilation holes outside the upper end of the housing 2, thus avoiding untimely subsequent drying, resulting in too long stacking time of the particles, causing adhesion between the particles, and thus affecting the quality of the production of pharmaceutical particles. The hexagonal prism 14 is arranged through the middle of the impeller 13 and can move up and down. The electric push rod 35 is started. The electric push rod 35 drives the hopper 5 to rise through the connecting plate 4. The hopper 5 drives the granulation plate 7 to move upward through the connecting ring 6 and separates from the groove 8 arranged at the top of the outer cylinder 1. The hopper 5 drives the sleeve 10 and the material distributing plate 12, the rotating shaft 11 and the hexagonal prism 14 to rise through the top plate 9, so that the hexagonal prism 14 is separated from the impeller 13, thus exposing the impeller 13 from the inside of the granulation plate 7 for convenient cleaning. At the same time, by removing the connecting bolts of the connecting ring 6 and the hopper 5, the granulation plate 7 can be replaced. Different granulation plates 7 have the same size and thickness, and the diameters of the holes arranged on the granulation plate 7 are different, so as to be used for processing pharmaceutical particles of different sizes.

[0034] The inner side of the upper end of the outer cylinder 1 is rotationally connected with a rotating ring 19. The lower side of the rotating ring 19 is fixedly connected with a plurality of spiral blades 21. The outer side of the spiral blades 21 is in close contact with the inside of the outer cylinder 1, and the inner side of the spiral blades 21 is in close contact with the outer wall of the housing 2. The upper end of the spiral blades 21 is fixedly connected with a second scraper 36 inside the rotating ring 19. The outer wall of the second scraper 36 is in close contact with the outer wall of the granulation plate 7. The lower end of the L-shaped plate 3 is provided with a second motor 22. The driving end of the second motor 22 is fixedly connected with a flat gear 23. The outer side of the flat gear 23 is meshed and connected with a toothed ring 20. The lower end of the toothed ring 20 is fixedly connected to the top of the rotating ring 19. The outer side of the lower end of the housing 2 is fixedly connected with a guide plate 24. The lower end of the guide plate 24 is fixedly connected with the inside of the lower end of the outer cylinder 1. A discharge plate 25 is arranged on the upper side of the guide plate 24. The upper end of the discharge plate 25 is fixedly connected to the lower end of the spiral blades 21. A discharge port 26 is arranged on the front side of the lower end of the outer cylinder 1.

[0035] Start the second motor 22 provided to drive the flat gear 23 to rotate. The rotating flat gear 23 cooperates with the toothed ring 20 to drive the rotating ring 19 to rotate. The rotating rotating ring 19 can drive the spiral blades 21 to rotate. Refer to Figure 2, the spiral blade 21 rotates counterclockwise, which can promote the downward flow of drug particles along the surface of the spiral blade 21, thus avoiding the accumulation of drug particles. Through the spiral arrangement of the spiral blade 21, the falling time of the particles can be increased, thereby increasing the drying time and avoiding the problems of uneven drying and incomplete drying. The rotating spiral blade 21 drives the second scraper 36 to rotate, and the rotating second scraper 36 is in close contact with the outer wall of the granulating plate 7, so that the extruded drug can be cut off to form particles, avoiding the attachment of the drug to the outer wall of the granulating plate 7. The rotating spiral blade 21 drives the discharge plate 25 to rotate, and the rotating discharge plate 25 can clean the drug particles between the guide plate 24 and the outer cylinder 1, and discharge them from the discharge port 26.

[0036] The middle part of the control box 28 is rotatably connected with a rotating cylinder 30. A plurality of fan blades 31 are fixedly connected to the outer wall of the rotating cylinder 30. An opening 32 is arranged between the plurality of fan blades 31 on the outside of the rotating cylinder 30. An air inlet for air intake is arranged at the bottom of the rotating cylinder 30. A hexagonal groove 33 is arranged in the middle of the upper end of the rotating cylinder 30. A through hole 34 is arranged in the middle of the upper end of the outer cylinder 1 above the hexagonal groove 33. The lower end of the hexagonal prism 14 passes through the through hole 34 and is inserted into the hexagonal groove 33 inside.

[0037] The arranged hexagonal prism 14 is inserted into the middle of the impeller 13 and passes through the bottom of the impeller 13. The protruding part passes through the middle of the through hole 34 and is inserted into the hexagonal groove 33 at the top of the rotating cylinder 30. When the hexagonal prism 14 drives the impeller 13 to rotate for granulation, it drives the rotating cylinder 30 to rotate. The rotating rotating cylinder 30 drives the fan blades 31 to rotate. Through the fan blades 31, the gas flow is promoted to form wind, which blows towards the heating tube 29, so that the heat generated by it passes through the ventilation holes arranged outside the housing 2 and contacts the drug particles on the spiral blade 21 to dry them. The lower end of the arranged rotating cylinder 30 penetrates through the middle of the control box 28 and communicates with the outside. When the rotating cylinder 30 and the fan blades 31 rotate, it is used for air circulation. The outside air enters from the bottom of the rotating cylinder 30, discharges from the opening 32, and then blows towards the heating tube 29 through the fan blades 31 to promote the diffusion of heat and improve the drying effect.

[0038] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirits of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A granulator for pharmaceutical production, characterized in that, It includes an outer cylinder (1), a housing (2) is arranged inside the outer cylinder (1), a flow guiding component is arranged between the outer cylinder (1) and the housing (2), a control box (28) is installed inside the lower end of the housing (2), a heating pipe (29) for drying is installed on the upper side of the control box (28), a base (27) for supporting the device is fixedly connected to the lower side of the control box (28), a wind force component is arranged in the middle of the control box (28), a groove (8) is arranged on the outer side of the upper end of the outer cylinder (1), an L-shaped plate (3) is fixedly connected to the rear side of the upper end of the outer cylinder (1), an electric push rod (35) is installed inside the L-shaped plate (3), a connecting plate (4) is fixedly connected to the driving end of the electric push rod (35), a hopper (5) is fixedly connected to the end of the connecting plate (4), a connecting ring (6) is fixedly connected to the outer part of the lower end of the hopper (5), a granulating plate (7) for granulation is fixedly connected to the lower end of the connecting ring (6), the lower end of the granulating plate (7) is embedded inside the groove (8), a top plate (9) is fixedly connected to the top of the hopper (5), a sleeve (10) is rotatably connected to the middle of the top plate (9), a rotating shaft (11) is rotatably connected inside the sleeve (10), a feeding plate (12) is fixedly connected to the lower end of the sleeve (10), a hexagonal prism (14) is fixedly connected to the bottom of the rotating shaft (11), an impeller (13) is arranged outside the hexagonal prism (14), the lower end of the impeller (13) is in close contact with the upper side of the outer cylinder (1), and the end of the impeller (13) is in close contact with the inside of the granulating plate (7).

2. The granulator for pharmaceutical production according to claim 1, characterized in that, A protective cover (15) is fixedly connected to the upper side of the top plate (9), a first motor (16) is fixedly connected to the rear side of the protective cover (15), and the driving end of the first motor (16) penetrates through the rear side of the protective cover (15) and is fixedly connected to a driving bevel gear (17).

3. A granulator for pharmaceutical production according to claim 2, characterized in that, Driven bevel gears (18) are meshed and connected to both the upper and lower sides of the driving bevel gear (17). The driven bevel gear (18) on the upper side of the driving bevel gear (17) is fixedly connected to the outer part of the upper end of the rotating shaft (11), and the driven bevel gear (18) on the lower side of the driving bevel gear (17) is fixedly connected to the outer part of the upper end of the sleeve (10).

4. A granulator for pharmaceutical production according to claim 1, characterized in that, The flow guiding component includes a rotating ring (19) rotatably connected to the inner side of the upper end of the outer cylinder (1). A plurality of spiral blades (21) are fixedly connected to the lower side of the rotating ring (19). The outer side of the spiral blades (21) is in close contact with the inside of the outer cylinder (1), and the inner side of the spiral blades (21) is in close contact with the outer wall of the housing (2). The upper end of the spiral blades (21) is fixedly connected with a second scraper (36) inside the rotating ring (19), and the outer wall of the second scraper (36) is in close contact with the outer wall of the granulating plate (7).

5. A granulator for pharmaceutical production according to claim 4, characterized in that, A second motor (22) is installed at the lower end of the L-shaped plate (3). The driving end of the second motor (22) is fixedly connected to a flat gear (23). The flat gear (23) is meshed and connected to a toothed ring (20) on the outside, and the lower end of the toothed ring (20) is fixedly connected to the top of the rotating ring (19).

6. The granulator for pharmaceutical production according to claim 4, characterized in that, A flow guiding plate (24) is fixedly connected to the outer side of the lower end of the housing (2). The lower end of the flow guiding plate (24) is fixedly connected to the inside of the lower end of the outer cylinder (1). A discharge plate (25) is arranged on the upper side of the flow guiding plate (24). The upper end of the discharge plate (25) is fixedly connected to the lower end of the spiral blade (21). A discharge port (26) is arranged on the front side of the lower end of the outer cylinder (1).

7. A granulator for pharmaceutical production according to claim 1, characterized in that, The wind power assembly includes a rotating cylinder (30) rotatably connected to the middle of a control box (28). A plurality of fan blades (31) are fixedly connected to the outer wall of the rotating cylinder (30). An opening (32) is arranged between the plurality of fan blades (31) on the outside of the rotating cylinder (30). An air inlet for air intake is arranged at the bottom of the rotating cylinder (30). A hexagonal groove (33) is arranged in the middle of the upper end of the rotating cylinder (30).

8. A granulator for pharmaceutical production according to claim 1, characterized in that, A through hole (34) is arranged above the hexagonal groove (33) in the middle of the upper end of the outer cylinder (1). The lower end of the hexagonal prism (14) passes through the through hole (34) and is inserted into the hexagonal groove (33).

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