Device and method for separating active substances in yak milk

By designing a device including centrifugation, defoaming and chromatography separation, the problem of uneven pH value caused by bubbles in yak milk is solved, and the acquisition rate of casein and the separation efficiency of active substances are improved.

CN120391341AActive Publication Date: 2025-08-01WESTERN YAK IND GRP CO LTD
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Patent Information

Application Number
CN202510535861.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-27
Publication Date
2025-08-01
Estimated Expiration
2045-04-27

AI Technical Summary

Technical Problem

In the prior art, when adjusting the pH value of yak milk, the local pH value is uneven due to the existence of bubbles, which affects the precipitation of casein and the separation effect of subsequent active substances.

Method used

A device including a first separation part, a first treatment part, a PH value adjustment part, a second separation part and a third separation part is adopted, and the skim yak milk, casein, lactoferrin and immunoglobulin are obtained respectively by centrifugation, defoaming treatment and chromatography separation. The bubbles are removed by using the exhaust branch tube and the breathable membrane, and the pre-cooling tube promotes the mixing of the acid solution and the skim yak milk.

Benefits of technology

Effectively eliminate bubbles, ensure uniformity of pH value, improve the acquisition rate of casein, ensure subsequent separation effect, and improve the separation efficiency of active substances.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention relates to the technical field of yak milk processing, and discloses a device and method for separating active substances in yak milk, and the device comprises a first separation part, a first treatment part, a PH value adjusting part, a second separation part and a third separation part which are connected in sequence; the first separation part is used for centrifugally separating yak milk to obtain skimmed yak milk; the first treatment part is used for defoaming skimmed yak milk; the second separation part is used for performing centrifugal separation on the skimmed yak milk subjected to pH value adjustment to obtain supernate and casein; the third separation part is used for performing chromatographic separation on the supernate to obtain lactoferrin and immune globulin. Defoaming treatment is conducted on the skimmed yak milk through the first treatment part, bubbles in the skimmed yak milk can be effectively eliminated, the situation that due to the fact that the bubbles occupy space, sufficient contact of an acid solution and the skimmed yak milk is hindered is prevented, the phenomenon that the local PH value is not uniform is prevented, the mixing effect of the skimmed yak milk and the acid solution is improved, and the casein obtaining rate is increased; the subsequent separation effect is ensured.
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Description

Technical Field

[0001] The present invention relates to the technical field of yak milk processing, and more particularly to a device and method for separating active substances in yak milk. Background Art

[0002] Yak milk is rich in active substances, such as casein, lactoferrin, and immunoglobulins. To separate the active substances in yak milk, the fat in the milk must first be removed to obtain skimmed milk. The casein and whey protein (i.e., the supernatant) are then separated. Whey protein (i.e., the supernatant) contains lactoferrin and immunoglobulins. The separation of casein will affect the subsequent yield of whey protein, thereby affecting the yield of lactoferrin and immunoglobulins.

[0003] In the existing technology, the pH value of skimmed yak milk is usually adjusted before centrifugal separation, which can easily increase the yield of casein. However, when the pH value is adjusted again, if the skimmed yak milk contains a large number of bubbles, the bubbles occupy a certain space, which will hinder the sufficient contact between the acid solution and the skimmed yak milk, resulting in local uneven pH value, making it impossible for some casein to be effectively precipitated, affecting the subsequent separation effect.

[0004] Therefore, it is necessary to propose a device and method for separating active substances in yak milk to at least partially solve the problems existing in the prior art. Summary of the Invention

[0005] The Summary of the Invention introduces a series of simplified concepts that will be further described in the Detailed Description of the Invention. The Summary of the Invention is not intended to limit the key features and essential features of the claimed technical solution, nor is it intended to determine the scope of protection of the claimed technical solution.

[0006] To at least partially solve the above problems, the present invention provides a device for separating active substances in yak milk, comprising: a first separation part, a first processing part, a pH value adjustment part, a second separation part, and a third separation part connected in sequence;

[0007] The first separation part is used to centrifuge the yak milk to obtain skimmed yak milk;

[0008] The first processing part is used for defoaming the skimmed yak milk;

[0009] The second separation part is used to centrifuge the skimmed yak milk after pH adjustment to obtain supernatant and casein;

[0010] The third separation part is used to perform chromatographic separation on the supernatant to obtain lactoferrin and immunoglobulin.

[0011] Preferably, it further includes: a second processing unit connected between the pH adjustment unit and the second separation unit, for pre-cooling the degreased yak milk after pH adjustment.

[0012] Preferably, the first processing unit includes:

[0013] A first housing, the two ends of which are respectively connected to the first separation unit and the pH adjustment unit through connecting pipes, and an exhaust port is provided on the first housing;

[0014] A plurality of exhaust branch pipes arranged in parallel are provided in the first housing, the two ends of the exhaust branch pipes are respectively connected to the connecting pipes, and the exhaust branch pipes are used to remove the bubbles in the passing degreased yak milk.

[0015] Preferably, the exhaust branch pipe includes:

[0016] A branch pipe main body, on which a plurality of bubble-removing cavities are arranged at intervals, the inner diameter of the bubble-removing cavity is larger than the inner diameter of the branch pipe main body, and the bubble-removing cavity can make the bubbles in the degreased yak milk stay on the top surface of the bubble-removing cavity without flowing forward with the degreased yak milk;

[0017] A breathable membrane is arranged on the top surface of the bubble-removing cavity, for allowing the bubbles in the degreased yak milk to pass through and preventing the degreased yak milk from passing through.

[0018] Preferably, it further includes:

[0019] An air extraction unit, connected to the exhaust port on the first housing, for making the pressure in the first housing less than the pressure in the branch pipe main body;

[0020] A first pressure sensor arranged on the first housing, for detecting the pressure in the first housing;

[0021] A second pressure sensor is arranged on the branch pipe main body or the connecting pipe, for detecting the pressure in the branch pipe main body.

[0022] Preferably, the second processing unit includes:

[0023] A second housing, the two ends of which are respectively connected to the pH adjustment unit and the second separation unit through connecting pipes, and a cooling medium inlet and a cooling medium outlet are provided on the second housing;

[0024] A pre-cooling pipe arranged in the second housing, the two ends of which are respectively connected to the connecting pipes.

[0025] Preferably, the pre-cooling pipe is a spiral pipe.

[0026] Preferably, the pre-cooling pipe includes a plurality of pre-cooling branch pipes arranged in parallel;

[0027] The pre-cooling branch pipe includes: a plurality of turbulator bodies connected in sequence, the middle of the turbulator body is a hollowed-out part, the cross-section of the hollowed-out part is a regular hexagon, and there are two flow channels on both sides of the hollowed-out part in the turbulator body;

[0028] After the degreased yak milk whose pH value has been adjusted enters the turbulator body, it is split by the hollowed-out part into two flow channels and then converges after passing through the hollowed-out part.

[0029] A method for separating active substances from yak milk includes:

[0030] Using the first separation part to centrifuge the impurity-removed yak milk at a rotational speed of 3000 r / min to 8000 r / min to obtain degreased yak milk;

[0031] Performing defoaming treatment on the degreased yak milk, then adjusting its pH value to 4.6 to 4.8, and then using the second separation part to centrifuge at a rotational speed of 8000 r / min to 10000 r / min to obtain supernatant and casein;

[0032] Using the third separation part to perform chromatographic separation on the supernatant to obtain lactoferrin and immunoglobulins.

[0033] Preferably, the defoaming treatment of the degreased yak milk includes:

[0034] Making the degreased yak milk flow in a split manner into a plurality of exhaust branch pipes, so that the bubbles in the degreased yak milk stay at the top of the defoaming cavity of the exhaust branch pipe and do not continue to flow forward with the degreased yak milk, and the bubbles are discharged through the breathable membrane at the top of the defoaming cavity.

[0035] Compared with the prior art, the present invention has at least the following beneficial effects:

[0036] For the device and method for separating active substances from yak milk according to the present invention, air may be mixed into the yak milk during the conveying process, thus forming bubbles in the yak milk. Under the separation action of the first separation part, some bubbles will be eliminated, but if air is trapped in the centrifuging yak milk, bubbles will still be generated. Therefore, it is necessary to perform defoaming treatment on the degreased yak milk through the first treatment part, which can effectively eliminate the bubbles in the degreased milk, prevent the bubbles from occupying a certain space and hindering the full contact between the acid solution and the degreased yak milk, thereby preventing the phenomenon of uneven local pH value, improving the mixing effect of the degreased yak milk and the acid solution, further improving the yield of casein, and ensuring the subsequent separation effect.

[0037] For the device and method for separating active substances from yak milk according to the present invention, other advantages, objectives and features of the present invention will be partially reflected by the following description and partially understood by those skilled in the art through the research and practice of the present invention. Description of the Drawings

[0038] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. They are used together with the embodiments of the present invention to explain the present invention and do not constitute a limitation to the present invention. In the accompanying drawings:

[0039] Figure 1 is a schematic structural diagram of the active substance separation device in yak milk according to the present invention;

[0040] Figure 2 is a schematic structural diagram of the first treatment part in the active substance separation device in yak milk according to the present invention;

[0041] Figure 3 is a schematic diagram of defatted yak milk containing bubbles in the branch pipe main body in the active substance separation device in yak milk according to the present invention;

[0042] Figure 4 is a schematic diagram of bubbles entering the bubble removal cavity in the active substance separation device in yak milk according to the present invention;

[0043] Figure 5 is a schematic structural diagram of the first solution of the pre-cooling pipe in the active substance separation device in yak milk according to the present invention;

[0044] Figure 6 is a schematic structural diagram of the second solution of the pre-cooling pipe in the active substance separation device in yak milk according to the present invention. Detailed Embodiments

[0045] The following further describes the present invention in detail with reference to the accompanying drawings and embodiments, so that those skilled in the art can implement it according to the description in the specification.

[0046] It should be understood that terms such as "having", "comprising", and "including" as used herein do not exclude the presence or addition of one or more other elements or their combinations.

[0047] As Figure 1 shown, the present invention provides an active substance separation device in yak milk, including: a first separation part 1, a first treatment part 2, a pH value adjustment part, a second separation part 3, and a third separation part 4 connected in sequence;

[0048] The first separation part 1 is used for centrifugally separating yak milk to obtain defatted yak milk;

[0049] The first treatment part 2 is used for defoaming the defatted yak milk;

[0050] The second separation part 3 is used for centrifugally separating the defatted yak milk after pH value adjustment to obtain a supernatant and casein;

[0051] Among them, the supernatant is whey protein;

[0052] The third separation unit 4 is used for chromatographic separation of the supernatant to obtain lactoferrin and immunoglobulins.

[0053] Further, the pH value adjustment unit includes: an acid solution addition unit 5 using a metering pump and a pH value detector 6.

[0054] The first separation unit 1 and the second separation unit 3 can adopt a disc separator, a tubular separator, etc. When separating yak milk through the first separation unit 1, the temperature is 4°C to 8°C, and the rotation speed is 3000 r / min to 8000 r / min. When separating the defatted yak milk after pH value adjustment through the second separation unit 3, the temperature is 4°C to 8°C, and the rotation speed is 8000 r / min to 10000 r / min;

[0055] Among them, the pH value of the defatted yak milk is adjusted by the pH value adjustment unit to 4.6 - 4.8, so that the defatted yak milk is fully mixed with the acid solution, then casein will precipitate, and then centrifugal separation is carried out through the second separation unit 3 to obtain whey protein and casein; the acid solution can be selected from lactic acid, citric acid, acetic acid, etc.;

[0056] The third separation unit 4 can select any chromatographic separation method in the prior art to separate lactoferrin and immunoglobulins, which will not be elaborated here;

[0057] Air may be mixed into the yak milk during transportation, thus forming bubbles in the yak milk. Under the separation action of the first separation unit 1, part of the bubbles will be eliminated. However, if air is trapped in the centrifuging yak milk, bubbles will still be generated. Therefore, it is necessary to defoam the defatted yak milk through the first treatment unit 2, which can effectively eliminate the bubbles in the defatted milk, prevent the bubbles from occupying a certain space and hindering the full contact between the acid solution and the defatted yak milk, thereby preventing the phenomenon of uneven local pH value, improving the mixing effect of the defatted yak milk and the acid solution, further improving the yield of casein, and ensuring the subsequent separation effect.

[0058] In one embodiment, it further includes: a second treatment unit 7 connected between the pH value adjustment unit and the second separation unit 3, which is used for pre-cooling the defatted yak milk after pH value adjustment.

[0059] Since the defatted yak milk coming out of the first separation unit 1 still needs to pass through the first treatment unit 2 and the pH adjustment unit (the temperature of mixing with the acid solution is not higher than 15°C to prevent protein denaturation), heat exchange will occur with the external environment and the temperature will increase. The temperature during separation in the second separation unit 3 is 4°C to 8°C. Therefore, in order to shorten the time for the defatted yak milk to cool down in the second separation unit 3, it is pre-cooled before entering the second separation unit 3. At the same time of pre-cooling, the acid solution can be fully mixed with the defatted yak milk, so that casein can be fully precipitated, improving the separation effect and separation efficiency.

[0060] In one embodiment, the first treatment unit 2 includes:

[0061] A first housing 21, the two ends of which are respectively connected to the first separation unit 1 and the pH adjustment unit through connecting pipes, and an exhaust port 22 is provided on the first housing 21;

[0062] A plurality of exhaust branch pipes 23 arranged in parallel are provided in the first housing 21. The two ends of the exhaust branch pipes 23 are respectively connected to the connecting pipes. The exhaust branch pipes 23 are used to remove the bubbles in the passing defatted yak milk.

[0063] The defatted yak milk is shunted from the connecting pipe into the plurality of exhaust branch pipes 23. The inner diameter of the exhaust branch pipes 23 is small, but the number is large, so it does not affect the conveying speed of the defatted yak milk. The sum of the cross-sectional areas of the plurality of exhaust branch pipes 23 corresponds to the cross-sectional area of the connecting pipe to ensure the conveying speed of the defatted yak milk;

[0064] When the defatted yak milk passes through the exhaust branch pipes 23, the bubbles can be discharged, and the gas is discharged from the exhaust port 22 of the first housing 21 to the outside; after the defatted yak milk passes through the plurality of exhaust branch pipes 23, it converges again and flows from the connecting pipe to the pH adjustment unit.

[0065] As Figure 2 shown, further, the exhaust branch pipe 23 includes:

[0066] A branch pipe main body 231, on which a plurality of de-bubbling cavities 232 are arranged at intervals. The inner diameter of the de-bubbling cavities 232 is larger than the inner diameter of the branch pipe main body 231. The de-bubbling cavities 232 can make the bubbles in the defatted yak milk stay on the top surface of the de-bubbling cavities 232 and not flow forward with the defatted yak milk;

[0067] A breathable membrane 233 is provided on the top surface of the de-bubbling cavity 232 for allowing the bubbles in the defatted yak milk to pass through and preventing the defatted yak milk from passing through.

[0068] Among them, the top surface of the defoaming cavity 232 is set higher than the top surface of the branch pipe main body 231, facilitating the bubbles to stay on the top surface of the defoaming cavity 232; a membrane with multiple holes can also be arranged in the defoaming cavity 232 to intercept the bubbles above the membrane, while the defatted yak milk can pass through the holes below, so as to further prevent the bubbles from flowing forward with the defatted milk;

[0069] The sum of the cross-sectional areas of the multiple branch pipe main bodies 231 corresponds to the cross-sectional area of the connecting pipe, and the inner diameter of the defoaming cavity 232 is larger than the inner diameter of the branch pipe main body 231. As Figure 3 shown, when there are bubbles in the defatted yak milk conveyed in the branch pipe main body 231, the bubbles enter the defoaming cavity 232. Since the bubbles are lighter than the defatted yak milk, as Figure 4 shown, the bubbles will contact the top surface of the defoaming cavity 232. The top surface of the defoaming cavity 232 is provided with a breathable membrane 233. Under the extrusion effect of the flowing defatted yak milk on the bubbles, the gas in the bubbles will be discharged from the breathable membrane 233 to achieve the purpose of defoaming.

[0070] As Figure 2 shown, in one embodiment, it further includes:

[0071] An air extraction part, connected to the exhaust port 22 on the first housing 21, for making the pressure in the first housing 21 less than the pressure in the branch pipe main body 231;

[0072] A first pressure sensor arranged on the first housing 21, for detecting the pressure in the first housing 21;

[0073] A second pressure sensor, arranged on the branch pipe main body 231 or the connecting pipe, for detecting the pressure in the branch pipe main body 231.

[0074] On the basis of the foregoing embodiment, an air extraction part is added in this embodiment to make the pressure in the first housing 21 less than the pressure in the branch pipe main body 231, so as to promote the bubbles to be discharged from the breathable membrane 233 and improve the defoaming efficiency; the arranged first pressure sensor and second pressure sensor can monitor the pressure changes in the first housing 21 and the branch pipe main body 231 in real time, thereby controlling the operation of the air extraction part, that is, extracting air from the first housing 21 to make the pressure inside it less than the pressure in the branch pipe main body 231. In this way, the bubbles in the defoaming cavity 232 can be discharged from the breathable membrane 233 under the extrusion effect of the flowing defatted yak milk;

[0075] In this embodiment, the air extraction part does not need to work all the time. As long as the pressure inside the first housing 21 is less than the pressure in the branch pipe main body 231, there is no need to perform the air extraction work.

[0076] As Figure 5 and Figure 6 shown, in one embodiment, the second processing part 7 includes:

[0077] A second housing 71, the two ends of which are respectively connected to the pH adjustment section and the second separation section 3 through connecting pipes, and a cooling medium inlet 72 and a cooling medium outlet 73 are provided on the second housing 71;

[0078] A precooling pipe disposed in the second housing 71, the two ends of which are respectively connected to the connecting pipes.

[0079] The cooling medium inlet 72 and the cooling medium outlet 73 are connected to a cooling medium circulation section, and the cooling medium circulation section is used for the circulation and heat exchange of the cooling medium to ensure that the cooling medium introduced into the second housing 71 can perform heat exchange with the precooling pipe, so as to ensure that the temperature of the defatted yak milk inside the precooling pipe is maintained at a set temperature (for example, 4°C to 8°C); the defatted yak milk added with an acid solution enters the precooling pipe from the connecting pipe, performs heat exchange with the cooling medium in the second housing 71 when flowing in the precooling pipe, and then is discharged from the precooling pipe.

[0080] As Figure 5 shown, in one embodiment, the precooling pipe is a spiral pipe 74.

[0081] This embodiment is the first solution for the precooling pipe. The precooling pipe is spiral, which can increase the contact time between the defatted yak milk and the cooling medium. At the same time, the defatted yak milk can also be fully mixed with the acid solution in the precooling pipe to promote the precipitation of casein.

[0082] As Figure 6 shown, in one embodiment, the precooling pipe includes a plurality of precooling branch pipes 75 arranged in parallel;

[0083] The precooling branch pipe 75 includes: a plurality of turbulator bodies 751 connected in sequence, the middle of the turbulator body 751 is a hollow part 752, the cross section of the hollow part 752 is a regular hexagon, and there are two flow channels on both sides of the hollow part 752 in the turbulator body 751;

[0084] After the defatted yak milk adjusted in pH enters the turbulator body 751, it is split into two flow channels by the hollow part 752 and converges after passing through the hollow part 752.

[0085] This embodiment is the second solution for the precooling pipe. The precooling pipe is a plurality of precooling branch pipes 75. By using the hollow part 752 of the turbulator body 751, the defatted yak milk added with an acid solution is split into two flow channels, and then converges before entering the next turbulator body 751. In this way, being split and converged multiple times can promote the full mixing of the acid solution and the defatted yak milk. Moreover, the bubbles in the defatted yak milk have been removed, and the bubbles will not occupy space and affect the contact between the acid solution and the defatted yak milk;

[0086] Since the middle part of the spoiler body 751 is a hollow part 752 and the multiple precooling branch pipes 75 are arranged at intervals in parallel, the cooling medium in the second housing 71 can flow between adjacent precooling branch pipes 75 and at the hollow part 752, and fully exchange heat with the precooling branch pipes 75, improving the heat exchange efficiency;

[0087] The precooling pipe is preferably arranged vertically. If the precooling pipe is arranged horizontally, the precooling pipe can be hermetically and rotatably connected to the connecting pipe. The rotation connection position of the two is outside the second housing 71, and the precooling pipe is controlled to rotate by the driving part to prevent casein deposition at the bottom of the horizontally arranged precooling pipe and prevent blockage.

[0088] The present invention also provides a method for separating active substances in yak milk, including:

[0089] Using the first separation part 1 to centrifuge the yak milk from which impurities have been removed at a rotation speed of 3000 r / min to 8000 r / min to obtain defatted yak milk;

[0090] Performing defoaming treatment on the defatted yak milk, then adjusting its pH value to 4.6 to 4.8, and then using the second separation part 3 to centrifuge at a rotation speed of 8000 r / min to 10000 r / min to obtain supernatant and casein;

[0091] Using the third separation part 4 to perform chromatography separation on the supernatant to obtain lactoferrin and immunoglobulins.

[0092] The first separation part 1 and the second separation part 3 can adopt a disc separator, a tubular separator, etc. When separating yak milk by the first separation part 1, the temperature is 4°C to 8°C and the rotation speed is 3000 r / min to 8000 r / min. When separating the defatted yak milk after pH adjustment by the second separation part 3, the temperature is 4°C to 8°C and the rotation speed is 8000 r / min to 10000 r / min;

[0093] Among them, the pH value of the defatted yak milk is adjusted by the pH adjustment part to 4.6 to 4.8 so that the defatted yak milk is fully mixed with the acid solution, then casein will precipitate, and then centrifuged by the second separation part 3 to obtain whey protein and casein; the acid solution can be selected from lactic acid, citric acid, acetic acid, etc.;

[0094] During the transportation of yak milk, air may be mixed in, thus forming bubbles in the yak milk. Under the separation effect of the first separation part 1, a part of the bubbles will be eliminated. However, if air is trapped in the centrifuging yak milk, bubbles will still be generated. Therefore, it is necessary to defoam the skimmed yak milk, which can effectively eliminate the bubbles in the skimmed milk, prevent the bubbles from occupying a certain space and hindering the full contact between the acid solution and the skimmed yak milk, thus preventing the phenomenon of uneven local pH value, improving the mixing effect of the skimmed yak milk and the acid solution, further improving the yield of casein, and ensuring the subsequent separation effect.

[0095] In one embodiment, the defoaming treatment of the skimmed yak milk includes:

[0096] The skimmed yak milk is shunted and transported into a plurality of exhaust branch pipes 23, so that the bubbles in the skimmed yak milk stay at the top of the defoaming cavity 232 of the exhaust branch pipe 23 and do not continue to flow forward with the skimmed yak milk. The bubbles are discharged through the breathable membrane 233 at the top of the defoaming cavity 232.

[0097] The skimmed yak milk is shunted from the connecting pipe into a plurality of exhaust branch pipes 23. The inner diameter of the exhaust branch pipes 23 is small, but the number is large, so it does not affect the transportation speed of the skimmed yak milk. The sum of the cross-sectional areas of the plurality of exhaust branch pipes 23 corresponds to the cross-sectional area of the connecting pipe to ensure the transportation speed of the skimmed yak milk;

[0098] When there are bubbles in the transported skimmed yak milk, the bubbles enter the defoaming cavity 232. Since the bubbles are lighter than the skimmed yak milk, as Figure 4 shown, the bubbles will contact the top surface of the defoaming cavity 232. The top surface of the defoaming cavity 232 is provided with a breathable membrane 233. Under the extrusion effect of the flowing skimmed yak milk on the bubbles, the gas in the bubbles will be discharged from the breathable membrane 233 to achieve the purpose of defoaming.

[0099] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present invention.

[0100] In the present invention, unless otherwise clearly stipulated and defined, terms such as "installation", "connection", "linkage", "fixation" and the like shall be construed in a broad sense. For example, it may be a fixed connection, a detachable connection, or integrated; it may be a mechanical connection, an electrical connection or communication with each other; it may be directly connected, or indirectly connected through an intermediate medium, and it may be the internal communication of two components or the interaction relationship between two components, unless otherwise clearly defined. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention may be understood according to specific circumstances.

[0101] Although the embodiments of the present invention have been disclosed as above, it is not limited to the applications listed in the specification and the embodiments. It can be fully applied to various fields suitable for the present invention. For those who are familiar with the art, additional modifications can be easily made. Therefore, without departing from the general concept defined by the present invention, the present invention is not limited to the specific details and the examples shown and described herein.

Claims

1. An apparatus for separating active substances in yak milk, characterized in that, Including: A first separation part (1), a first processing part (2), a pH value adjustment part, a second separation part (3) and a third separation part (4) connected in sequence; The first separation part (1) is used for centrifugally separating yak milk to obtain defatted yak milk; The first processing part (2) is used for defoaming the defatted yak milk; The second separation part (3) is used for centrifugally separating the defatted yak milk after pH value adjustment to obtain supernatant and casein; The third separation part (4) is used for chromatographically separating the supernatant to obtain lactoferrin and immunoglobulins.

2. The active substance separation device in yak milk according to claim 1, characterized in that Also including: A second processing part (7) connected between the pH value adjustment part and the second separation part (3), which is used for pre-cooling the defatted yak milk after pH value adjustment.

3. The active substance separation device in yak milk according to claim 1, wherein, The first processing part (2) includes: A first housing (21), the two ends of which are respectively connected to the first separation part (1) and the pH value adjustment part through connecting pipes, and an exhaust port (22) is provided on the first housing (21); A plurality of exhaust branch pipes (23) arranged in parallel are provided in the first housing (21), the two ends of the exhaust branch pipes (23) are respectively connected to the connecting pipes, and the exhaust branch pipes (23) are used for removing the bubbles in the passing defatted yak milk.

4. The active substance separation device in yak milk according to claim 3, characterized in that, The exhaust branch pipe (23) includes: A branch pipe main body (231) on which a plurality of defoaming cavities (232) are arranged at intervals, the inner diameter of the defoaming cavities (232) is larger than the inner diameter of the branch pipe main body (231), and the defoaming cavities (232) can make the bubbles in the defatted yak milk stay on the top surface of the defoaming cavities (232) without flowing forward with the defatted yak milk; A breathable membrane (233) is provided on the top surface of the defoaming cavity (232), which is used for allowing the bubbles in the defatted yak milk to pass through and preventing the defatted yak milk from passing through.

5. The active substance separation device for yak milk according to claim 4, wherein, Also including: An air extraction part, which is connected to the exhaust port (22) on the first housing (21) and is used for making the pressure in the first housing (21) less than the pressure in the branch pipe main body (231); A first pressure sensor provided on the first housing (21) for detecting the pressure in the first housing (21); A second pressure sensor is provided on the branch pipe main body (231) or the connecting pipe for detecting the pressure in the branch pipe main body (231).

6. The active substance separation device for yak milk according to claim 2, characterized in that, The second processing part (7) includes: A second housing (71), the two ends of which are respectively connected to the pH value adjustment part and the second separation part (3) through connecting pipes, and a cooling medium inlet (72) and a cooling medium outlet (73) are provided on the second housing (71); A pre-cooling pipe provided in the second housing (71), the two ends of which are respectively connected to the connecting pipes.

7. The active substance separation device in yak milk according to claim 6, characterized in that, The pre-cooling pipe is a spiral pipe (74).

8. The active substance separation device in yak milk according to claim 6, characterized in that, The pre-cooling pipe includes a plurality of pre-cooling branch pipes (75) arranged in parallel; The pre-cooling branch pipe (75) includes: a plurality of turbulator bodies (751) connected in sequence, the middle part of the turbulator body (751) is a hollow part (752), the cross section of the hollow part (752) is a regular hexagon, and there are two flow channels on both sides of the hollow part (752) in the turbulator body (751); After the degreased yak milk with the pH value adjusted enters the turbulence main body (751), it is shunted to two flow channels by the hollowed part (752) and then converges after passing through the hollowed part (752).

9. A method for separating active substances in yak milk, which is separated by using the device for separating active substances in yak milk according to any one of claims 1-8, characterized in that, Including: Using the first separation part (1) to centrifugally separate the yak milk with impurities removed at a rotational speed of 3000 r / min to 8000 r / min to obtain degreased yak milk; Performing defoaming treatment on the degreased yak milk, then adjusting its pH value to 4.6 to 4.8, and then using the second separation part (3) to perform centrifugal separation at a rotational speed of 8000 r / min to 10000 r / min to obtain supernatant and casein; Using the third separation part (4) to perform chromatography separation on the supernatant to obtain lactoferrin and immunoglobulin.

10. The method for separating active substances from yak milk according to claim 9, characterized in that, Performing defoaming treatment on the degreased yak milk, including: Shunting and transporting the degreased yak milk into a plurality of exhaust branch pipes (23), making the bubbles in the degreased yak milk stay at the top of the defoaming cavity (232) of the exhaust branch pipe (23) without flowing forward with the degreased yak milk, and the bubbles are discharged through the breathable membrane (233) at the top of the defoaming cavity (232).

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