Traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis and a preparation method thereof. The traditional Chinese medicine composition is prepared from, by weight, 12-15 parts of radix rehmanniae, 6-9 parts of rhizoma picrorhizae, 10-12 parts of radix asparagi, 12-15 parts of radix rehmanniae preparata, 10-12 parts of radix ophiopogonis, 8-10 parts of radix gentianae macrophyllae, 10-15 parts of radix adenophorae, 6-9 parts of rhizoma pini, 9-12 parts of radix scutellariae, 8-10 parts of rhizoma corydalis, 9-12 parts of fritillary bulb, 6-9 parts of sweet wormwood herb, 10-12 parts of colla corii asini, 9-12 parts of rhizoma anemarrhenae, 8-10 parts of mulberry bark, 9-12 parts of rhizoma bletillae, 6-9 parts of September, 8-10 parts of cortex moutan, 6-9 parts of radix notoginseng, 10-12 parts of According to the composition disclosed by the invention, a compound preparation with a synergistic treatment effect is formed through scientific compatibility of multiple traditional Chinese medicinal materials. According to the invention, radix rehmanniae and radix rehmanniae preparata are used as monarch drugs to nourish yin and blood; radix asparagi, radix ophiopogonis and adenophora stricta are used as ministerial drugs to enhance the effect of moistening the lung; radix scutellariae, rhizoma anemarrhenae, mulberry bark and the like are used for clearing heat and eliminating phlegm; and the liquorice is used for harmonizing the medicines. All the components have a synergistic effect according to a specific proportion, and the traditional Chinese medicine can improve pneumoconiosis fibrosis and inhibit mycobacterium tuberculosis, so that the effect of treating both symptoms and root causes is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating pneumoconiosis combined with pulmonary tuberculosis and a preparation method thereof. Background Art

[0002] In modern society, pneumoconiosis and pulmonary tuberculosis are both common respiratory diseases. Their combined presence can be complex and difficult to treat. Current Western medical treatments often rely on anti-tuberculosis drugs combined with glucocorticoids, but long-term use can easily lead to drug resistance and significant side effects. Summary of the Invention

[0003] In view of this, in order to solve the problems existing in the technical background, the present invention proposes a Chinese medicine composition for treating pneumoconiosis combined with pulmonary tuberculosis and its preparation method. The specific technical solution is as follows:

[0004] A traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis comprises, by weight, 12-15 parts of raw rehmannia, 6-9 parts of coptis root, 10-12 parts of asparagus cochinchinensis, 12-15 parts of cooked rehmannia, 10-12 parts of ophiopogon, 8-10 parts of gentiana macrophylla, 10-15 parts of adenophora, 6-9 parts of benign radix sylvestris, 9-12 parts of scutellaria baicalensis, 8-10 parts of galangal, 9-12 parts of fritillaria fringefolia, 6-9 parts of artemisia annua, 10-12 parts of donkey hide gelatin, 9-12 parts of anemarrhena rhizome, 8-10 parts of mulberry bark, 9-12 parts of bletilla striata, 6-9 parts of september regia, 8-10 parts of bone bark, 6-9 parts of notoginseng, 10-12 parts of white peony root, 9-12 parts of stemona, and 3-6 parts of liquorice.

[0005] Furthermore, the ingredients include 12 parts of raw rehmannia, 6 parts of coptis chinensis, 10 parts of asparagus cochinchinensis, 12 parts of cooked rehmannia, 10 parts of ophiopogon japonicus, 8 parts of gentiana macrophylla, 10 parts of adenophora scutellariae, 6 parts of betel nut, 9 parts of scutellaria baicalensis, 8 parts of hupehenia hupehensis, 9 parts of fritillaria thunbergii, 6 parts of artemisia annua, 10 parts of donkey hide gelatin, 9 parts of anemarrhena rhizome, 8 parts of mulberry bark, 9 parts of bletilla striata, 6 parts of september 24, 8 parts of bone bark, 6 parts of panax notoginseng, 10 parts of white peony root, 9 parts of stemona radix, and 3 parts of liquorice.

[0006] Furthermore, the ingredients include 15 parts of raw rehmannia, 9 parts of hu lian, 12 parts of asparagus cochinchinensis, 15 parts of cooked rehmannia, 12 parts of ophiopogon japonicus, 10 parts of gentiana macrophylla, 15 parts of adenophora, 9 parts of benjaculate larvae, 12 parts of scutellaria baicalensis, 10 parts of hu lian, 12 parts of fritillaria thunbergii, 9 parts of artemisia annua, 12 parts of donkey hide gelatin, 12 parts of anemarrhena, 10 parts of mulberry bark, 12 parts of bletilla striata, 9 parts of september 2019, 10 parts of bone bark, 9 parts of panax notoginseng, 12 parts of white peony root, 12 parts of stemona, and 6 parts of liquorice.

[0007] Furthermore, the ingredients include 13.5 parts of Rehmannia root, 7 parts of Coptis chinensis, 11 parts of Asparagus cochinchinensis, 13 parts of Rehmannia root, 11 parts of Radix Ophiopogonis, 9 parts of Gentiana macrophylla, 13 parts of Adenophora root, 8 parts of Radix Adenophorae, 11 parts of Scutellaria baicalensis, 9 parts of Rhizoma Cyperi, 11 parts of Fritillaria thunbergii, 8 parts of Artemisia annua, 11 parts of Donkey-hide gelatin, 11 parts of Rhizoma Anemarrhenae, 9 parts of Morus alba, 10 parts of Bletilla striata, 8 parts of Rhizoma Sinensis, 9 parts of Cortex Psoraleae, 8 parts of Radix Notoginseng, 11 parts of White Peony Root, 11 parts of Radix Stemonae, and 4 parts of Radix Glycyrrhizae.

[0008] A preparation method of a traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis, comprising the following steps:

[0009] Step 1: Take the selected medicinal materials, and first separately pulverize turtle shell and notoginseng into fine powder of 120 meshes.

[0010] Step 2: Decoct the remaining medicinal materials three times with water, and combine the filtrates and concentrate to a relative density of 1.25.

[0011] Step 3: After adding donkey-hide gelatin, mix it with the aforementioned fine powder to make granules.

[0012] Further, the water addition amounts for decocting the medicinal materials three times in Step 2 are 8 times, 6 times, and 4 times the amount of the medicinal materials in sequence.

[0013] Adopting the above technical solution, the following beneficial effects are achieved:

[0014] The composition of the present invention forms a compound preparation with a synergistic therapeutic effect through the scientific compatibility of multiple traditional Chinese medicinal materials. In the present invention, raw rehmannia root and prepared rehmannia root together serve as the monarch drugs to nourish yin and blood; assisted by asparagus root, dwarf lilyturf root, and glehnia root as ministerial drugs to enhance the effect of moistening the lungs; adjuvanted by scutellaria baicalensis, anemarrhena rhizome, and mulberry bark to clear heat and resolve phlegm, and notoginseng and bletilla striata to activate blood circulation and stop bleeding; and licorice root is used as the envoy drug to harmonize the properties of various drugs. Each component acts synergistically in a specific proportion, can not only improve pneumoconiosis fibrosis but also inhibit tubercle bacilli, achieving the effect of treating both the symptoms and the root causes. Specific embodiments

[0015] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0016] Example 1, A traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis, according to the weight ratio, 12 parts of raw rehmannia root, 6 parts of picrorhiza rhizome, 10 parts of asparagus root, 12 parts of prepared rehmannia root, 10 parts of dwarf lilyturf root, 8 parts of gentian root, 10 parts of glehnia root, 6 parts of turtle shell, 9 parts of scutellaria baicalensis, 8 parts of stellaria root, 9 parts of fritillaria thunbergii, 6 parts of artemisia annua, 10 parts of donkey-hide gelatin, 9 parts of anemarrhena rhizome, 8 parts of mulberry bark, 9 parts of bletilla striata, 6 parts of polygonum multiflorum, 8 parts of cortex lycii radicis, 6 parts of notoginseng, 10 parts of white peony root, 9 parts of stemona root, 3 parts of licorice root.

[0017] A preparation method of a traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis, comprising the following steps: Step 1, take the selected medicinal materials, and first separately pulverize turtle shell and notoginseng into fine powder of 120 meshes; Step 2, decoct the remaining medicinal materials three times with water, and combine the filtrates and concentrate to a relative density of 1.25; Step 3, add donkey-hide gelatin, and mix with the aforementioned fine powder to make granules. Further, the water addition amounts in the three times of decocting the medicinal materials in Step 2 are successively 8 times, 6 times, and 4 times the amount of the medicinal materials. The clinical usage is 3 times a day, 6 g of granules each time, taken warm with water, and the course of treatment is 3 months.

[0018] Example 2, a traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis, according to the weight ratio, 15 parts of rehmannia root, 9 parts of picrorhiza rhizome, 12 parts of asparagus root, 15 parts of prepared rehmannia root, 12 parts of ophiopogon root, 10 parts of gentian, 15 parts of adenophora root, 9 parts of turtle shell, 12 parts of skullcap root, 10 parts of stellaria root, 12 parts of fritillary bulb, 9 parts of sweet wormwood, 12 parts of donkey-hide gelatin, 12 parts of anemarrhena rhizome, 10 parts of mulberry bark, 12 parts of bletilla striata, 9 parts of polygonum multiflorum, 10 parts of cortex lycii radicis, 9 parts of notoginseng, 12 parts of white peony root, 12 parts of stemona root, 6 parts of licorice root.

[0019] A preparation method of a traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis, comprising the following steps: Step 1, take the selected medicinal materials, and first separately pulverize turtle shell and notoginseng into fine powder of 120 meshes; Step 2, decoct the remaining medicinal materials three times with water, and combine the filtrates and concentrate to a relative density of 1.25; Step 3, add donkey-hide gelatin, and mix with the aforementioned fine powder to make granules. Further, the water addition amounts in the three times of decocting the medicinal materials in Step 2 are successively 8 times, 6 times, and 4 times the amount of the medicinal materials. The clinical usage is 3 times a day, 6 g of granules each time, taken warm with water, and the course of treatment is 3 months.

[0020] Example 3, a traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis, according to the weight ratio, 13.5 parts of rehmannia root, 7 parts of picrorhiza rhizome, 11 parts of asparagus root, 13 parts of prepared rehmannia root, 11 parts of ophiopogon root, 9 parts of gentian, 13 parts of adenophora root, 8 parts of turtle shell, 11 parts of skullcap root, 9 parts of stellaria root, 11 parts of fritillary bulb, 8 parts of sweet wormwood, 11 parts of donkey-hide gelatin, 11 parts of anemarrhena rhizome, 9 parts of mulberry bark, 10 parts of bletilla striata, 8 parts of polygonum multiflorum, 9 parts of cortex lycii radicis, 8 parts of notoginseng, 11 parts of white peony root, 11 parts of stemona root, 4 parts of licorice root.

[0021] A preparation method of a traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis, comprising the following steps: Step 1, take the selected medicinal materials, and first separately pulverize turtle shell and notoginseng into fine powder of 120 meshes; Step 2, decoct the remaining medicinal materials three times with water, and combine the filtrates and concentrate to a relative density of 1.25; Step 3, add donkey-hide gelatin, and mix with the aforementioned fine powder to make granules. Further, the water addition amounts in the three times of decocting the medicinal materials in Step 2 are successively 8 times, 6 times, and 4 times the amount of the medicinal materials. The clinical usage is 3 times a day, 6 g of granules each time, taken warm with water, and the course of treatment is 3 months.

[0022] In Examples 1 to 3, raw rehmannia root and prepared rehmannia root are combined to form the basic framework for nourishing yin and blood. Asparagus root, dwarf lilyturf tuber, and glehnia root are used as ministerial drugs to enhance the effect of moistening the lungs and promoting the production of body fluids. In Example 2, the upper limit dose is adopted, focusing on strengthening the effects of clearing heat and resolving phlegm and anti-tuberculosis; in Example 1, the lower limit dose is taken, which is more suitable for patients with weak constitutions; in Example 3, the intermediate value is taken. Modern research has confirmed that drugs such as stemona root, scutellaria root, and bletilla striata in the formula have the effect of inhibiting mycobacterium tuberculosis and all maintain an effective dose range (9 - 12 parts), forming a pharmacological synergy with the immunomodulatory effect of donkey-hide gelatin (10 - 12 parts).

[0023] Case 1: A 45-year-old male miner was diagnosed with stage III silicosis complicated with cavitary pulmonary tuberculosis for 2 years. He had drug-induced liver injury after long-term use of isoniazid and rifampicin. After switching to the formula of Example 2, the hemoptysis volume decreased by 50% after 10 days of taking the medicine, and the acid-fast bacilli in the sputum smear decreased from (+++) to (+). After 3 months of treatment, CT showed that the 4.2 cm × 3.8 cm cavity in the right upper lung shrank to 1.5 cm × 1.2 cm, the fibrotic lesions in the lung field decreased, and the DLCO (diffusing capacity of the lung for carbon monoxide) increased from 48% of the predicted value to 65%. During this period, the liver function indicators remained stable, no adverse reactions such as bone marrow suppression were seen, the weight increased by 3.5 kg, and the traditional Chinese medicine syndrome score (including cough, chest pain, night sweats, etc.) decreased from 28 points to 9 points.

[0024] Case 2: A 52-year-old female textile worker had stage II silicosis complicated with multi-drug resistant pulmonary tuberculosis and was resistant to streptomycin and ethambutol. The treatment plan of Example 3 was adopted in combination with levofloxacin. After 4 weeks, the body temperature returned to normal and the night sweats disappeared. When the treatment reached 2 months, the sputum culture became negative and the moist rales in the lungs decreased on auscultation. At the end of the treatment course, chest X-ray showed that 70% of the infiltrative lesions in the left upper lung were absorbed, the hilar lymph nodes shrank, and the 6-minute walking distance improved from 320 meters to 410 meters. Laboratory tests showed that the CD4+ lymphocyte count increased from 356 / μl to 589 / μl, and the serum IL-6 level decreased from 32.7 pg / ml to 11.3 pg / ml, confirming that the formula has an immunomodulatory effect.

[0025] Case 3: A 38-year-old male tunnel construction worker had stage I silicosis complicated with hematogenous disseminated pulmonary tuberculosis and a weak constitution (BMI 17.8). The low-dose formula of Example 1 was used. After 1 week, the appetite improved significantly. After 3 weeks, the hemoglobin increased from 82 g / L to 105 g / L. When the chest CT was rechecked after 8 weeks of treatment, the miliary nodules in both lungs decreased by about 60%, and the arterial oxygen partial pressure (PaO2) increased from 65 mmHg to 82 mmHg. It is worth noting that this patient often had gastrointestinal reactions when taking anti-tuberculosis drugs in the past, but no vomiting or diarrhea occurred after switching to traditional Chinese medicine granules, and the treatment compliance reached 95%. During the half-year follow-up, no tuberculosis recurrence was seen, and the FEV1 / FVC ratio of lung function improved from 58% to 67%.

[0026] The basic principles and main features of the present invention have been described above. Those skilled in the art should understand that the present invention is not limited by the above embodiments. What is described in the above embodiments and the specification only illustrates the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed. The scope of the invention claimed is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating pneumoconiosis combined with pulmonary tuberculosis, characterized in that: According to the weight ratio, it includes 12 - 15 parts of Rehmannia glutinosa Libosch., 6 - 9 parts of Picrorhiza scrophulariiflora Pennell, 10 - 12 parts of Asparagus cochinchinensis (Lour.) Merr., 12 - 15 parts of Rehmannia glutinosa Libosch. preparata, 10 - 12 parts of Ophiopogon japonicus (Thunb.) Ker - Gawl., 8 - 10 parts of Gentiana macrophylla Pall., 10 - 15 parts of Adenophora stricta Miq., 6 - 9 parts of Trionyx sinensis Wiegmann, 9 - 12 parts of Scutellaria baicalensis Georgi, 8 - 10 parts of Stellaria dichotoma L. var. lanceolata Bge., 9 - 12 parts of Fritillaria thunbergii Miq., 6 - 9 parts of Artemisia annua L., 10 - 12 parts of Colla Corii Asini, 9 - 12 parts of Anemarrhena asphodeloides Bge., 8 - 10 parts of Mori Cortex, 9 - 12 parts of Bletilla striata (Thunb.) Reichb. f., 6 - 9 parts of September (the meaning of this 'September' is not clear in this context), 8 - 10 parts of Lycii Radicis Cortex, 6 - 9 parts of Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow, 10 - 12 parts of Paeonia lactiflora Pall., 9 - 12 parts of Stemona japonica (Blume) Miq., 3 - 6 parts of Glycyrrhiza uralensis Fisch..

2. The traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis according to claim 1, wherein, The said 12 parts of Rehmannia glutinosa Libosch., 6 parts of Picrorhiza scrophulariiflora Pennell, 10 parts of Asparagus cochinchinensis (Lour.) Merr., 12 parts of Rehmannia glutinosa Libosch. preparata, 10 parts of Ophiopogon japonicus (Thunb.) Ker - Gawl., 8 parts of Gentiana macrophylla Pall., 10 parts of Adenophora stricta Miq., 6 parts of Trionyx sinensis Wiegmann, 9 parts of Scutellaria baicalensis Georgi, 8 parts of Stellaria dichotoma L. var. lanceolata Bge., 9 parts of Fritillaria thunbergii Miq., 6 parts of Artemisia annua L., 10 parts of Colla Corii Asini, 9 parts of Anemarrhena asphodeloides Bge., 8 parts of Mori Cortex, 9 parts of Bletilla striata (Thunb.) Reichb. f., 6 parts of September (the meaning of this 'September' is not clear in this context), 8 parts of Lycii Radicis Cortex, 6 parts of Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow, 10 parts of Paeonia lactiflora Pall., 9 parts of Stemona japonica (Blume) Miq., 3 parts of Glycyrrhiza uralensis Fisch..

3. The traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis according to claim 1, wherein, The said 15 parts of Rehmannia glutinosa Libosch., 9 parts of Picrorhiza scrophulariiflora Pennell, 12 parts of Asparagus cochinchinensis (Lour.) Merr., 15 parts of Rehmannia glutinosa Libosch. preparata, 12 parts of Ophiopogon japonicus (Thunb.) Ker - Gawl., 10 parts of Gentiana macrophylla Pall., 15 parts of Adenophora stricta Miq., 9 parts of Trionyx sinensis Wiegmann, 12 parts of Scutellaria baicalensis Georgi, 10 parts of Stellaria dichotoma L. var. lanceolata Bge., 12 parts of Fritillaria thunbergii Miq., 9 parts of Artemisia annua L., 12 parts of Colla Corii Asini, 12 parts of Anemarrhena asphodeloides Bge., 10 parts of Mori Cortex, 12 parts of Bletilla striata (Thunb.) Reichb. f., 9 parts of September (the meaning of this 'September' is not clear in this context), 10 parts of Lycii Radicis Cortex, 9 parts of Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow, 12 parts of Paeonia lactiflora Pall., 12 parts of Stemona japonica (Blume) Miq., 6 parts of Glycyrrhiza uralensis Fisch..

4. The traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis according to claim 1, wherein, The said 13.5 parts of Rehmannia glutinosa Libosch., 7 parts of Picrorhiza scrophulariiflora Pennell, 11 parts of Asparagus cochinchinensis (Lour.) Merr., 13 parts of Rehmannia glutinosa Libosch. preparata, 11 parts of Ophiopogon japonicus (Thunb.) Ker - Gawl., 9 parts of Gentiana macrophylla Pall., 13 parts of Adenophora stricta Miq., 8 parts of Trionyx sinensis Wiegmann, 11 parts of Scutellaria baicalensis Georgi, 9 parts of Stellaria dichotoma L. var. lanceolata Bge., 11 parts of Fritillaria thunbergii Miq., 8 parts of Artemisia annua L., 11 parts of Colla Corii Asini, 11 parts of Anemarrhena asphodeloides Bge., 9 parts of Mori Cortex, 10 parts of Bletilla striata (Thunb.) Reichb. f., 8 parts of September (the meaning of this 'September' is not clear in this context), 9 parts of Lycii Radicis Cortex, 8 parts of Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow, 11 parts of Paeonia lactiflora Pall., 11 parts of Stemona japonica (Blume) Miq., 4 parts of Glycyrrhiza uralensis Fisch..

5. A preparation method of a traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis, characterized in that, It includes the following steps: Step 1, take the selected herbs, first separately crush Trionyx sinensis Wiegmann and Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow into fine powder of 120 meshes; Step 2, decoct the remaining herbs three times with water, and combine the filtrates and concentrate to a relative density of 1.25; Step 3, add Colla Corii Asini and then mix with the aforementioned fine powder to make granules.

6. The preparation method of a traditional Chinese medicine composition for treating pneumoconiosis complicated with pulmonary tuberculosis according to claim 5, characterized in that, In the three - time water decoction of the herbs in Step 2, the water addition amounts are successively 8 times, 6 times, and 4 times the amount of the herbs.