Formula of anti-cancer and cancer-controlling hypoglycemic medicine prepared by combining crocodile extract and traditional Chinese medicines

Abstract

The invention relates to the technical field of anti-cancer and cancer-controlling hypoglycemic drug formulas, in particular to an anti-cancer and cancer-controlling hypoglycemic drug formula formed by combining crocodile extract and traditional Chinese medicine. Comprising the following components: 50-100 g of crocodile meat and bone extract, 25-50 g of raw radix astragali, 25-50 g of radix rehmanniae recen, 15-45 g of rhizoma atractylodis, 30-60 g of radix scrophulariae, 10-35 g of radix puerariae, 25-50 g of radix salviae miltiorrhizae, 100-300 g of black tartary buckwheat powder, 20-50 g of corn stigma, 30-60 g of wax gourd seed powder, 20-50 g of folium mori and 10-35 g of bitter gourd powder. The crocodile extract and the traditional Chinese medicines are natural sources, chemical synthesis medicine residues are avoided, the long-term use safety is superior to that of traditional sulfonylurea, metformin and the like, the low-temperature extraction and supercritical CO2 extraction technology retains active ingredients to the maximum extent, generation of harmful substances is reduced, and compared with sulfonylurea and other traditional hypoglycemic drugs, the formula adjusts blood sugar through multiple ways, and the effect of reducing blood sugar is achieved. The components such as the astragalus membranaceus and the salvia miltiorrhiza can improve the immunity and reduce the infection risk in the chemotherapy or hypoglycemic treatment period.

Description

Technical Field

[0001] The present invention relates to the technical field of cancer prevention, control and hypoglycemic drug formulas, and in particular to a cancer prevention, control and hypoglycemic drug formula comprising a crocodile extract and a traditional Chinese medicine. Background Art

[0002] Traditional hypoglycemic drugs mostly use sulfonylureas, metformin, α-glucosidase inhibitors and insulin sensitizers; while traditional anticancer drugs lack selectivity for normal cells and tumor cells, and mostly focus on directly killing tumor cells.

[0003] Traditional cancer prevention, cancer control and blood sugar lowering drugs mostly target a single target or pathological link, and it is difficult to fully cover the multiple needs of cancer prevention, cancer control and blood sugar lowering. Long-term use of some traditional drugs may increase the metabolic burden of the liver and kidneys, and even induce other diseases. New blood sugar lowering drugs such as GLP-1 receptor agonists and DPP-4 inhibitors are expensive. Although traditional drugs are cheap, their efficacy and safety are limited.

[0004] Therefore, in view of the fact that the above-mentioned cancer prevention, cancer control and blood sugar lowering drug formulas mostly target a single target or pathological link, it is difficult to fully cover the multiple needs of cancer prevention, cancer control and blood sugar lowering, and the problem of large side effects with long-term use, a cancer prevention, cancer control and blood sugar lowering drug formula can be designed with a combination of crocodile extract and traditional Chinese medicine. Summary of the Invention

[0005] In order to overcome the problem that traditional cancer prevention, cancer control and blood sugar lowering drug formulas are mostly targeted at a single target or pathological link, it is difficult to fully cover the multiple needs of cancer prevention, cancer control and blood sugar lowering, and the long-term use has large side effects.

[0006] The technical solution of the present invention is: a cancer prevention, control and hypoglycemic drug formula composed of crocodile extract and traditional Chinese medicine, comprising the following components: 50-100g of crocodile meat and bone extract, 25-50g of raw astragalus, 25-50g of raw rehmannia, 15-45g of atractylodes, 30-60g of figwort, 10-35g of kudzu root, 25-50g of salvia miltiorrhiza, 100-300g of black tartary buckwheat powder, 20-50g of corn silk, 30-60g of wax gourd seed powder, 20-50g of mulberry leaf and 10-35g of bitter melon powder.

[0007] Preferably, the crocodile meat and bone extracts are obtained from artificially farmed crocodiles, including Siamese crocodiles and saltwater crocodiles, and the meat and bones are taken from individuals that died naturally.

[0008] Preferably, the black tartary buckwheat flour is cooked black tartary buckwheat flour.

[0009] Preferably, the preparation steps are as follows:

[0010] S1: Preparation of crocodile extract

[0011] S11: Take frozen crocodile meat and bones, thaw them in running water, wash them, remove surface impurities, and grind them;

[0012] S12: Using low-temperature extraction technology to extract the active ingredients, filtering, concentrating and then freeze-drying to obtain crocodile extract powder;

[0013] S2: Chinese herbal medicine extraction

[0014] S21: Weigh raw astragalus, raw rehmannia, atractylodes, scrophularia, kudzu root, salvia miltiorrhiza, corn silk, and mulberry leaves in proportion, soak in 8 times the amount of water for 1 hour, bring to a boil over high heat, then simmer over low heat for 1.5 hours, twice in total, and combine the decoctions;

[0015] S22: After filtering the decoction, the decoction is concentrated under reduced pressure at 60°C to a relative density of 1.2-1.3, 95% ethanol is slowly added until the alcohol content reaches 60%, and the decoction is allowed to stand at 4°C for 24 hours. The supernatant is centrifuged and the ethanol is recovered and further concentrated until there is no alcohol smell, thereby obtaining a dark brown thick paste of traditional Chinese medicine;

[0016] S3: Powder mixing

[0017] Put crocodile extract powder, Chinese medicine paste, black buckwheat powder, wax gourd seed powder and bitter melon powder into a mixer, stir at 15 r / min for 20 minutes, and pass through an 80-mesh sieve to remove lumps;

[0018] S4: Made into pill shape

[0019] Using an appropriate amount of water or honey as a binder, the powder is made into a soft material, which is then made into pills with a diameter of 5mm-6mm using a pill making machine. The pills are then dried at a low temperature of 40-50°C to prevent high temperatures from destroying the active ingredients.

[0020] S5: Packaging and Storage

[0021] Put the pills into a sealed bottle or aluminum foil bag and store them in a dark, dry and cool place to prevent them from moisture and oxidation and extend the shelf life.

[0022] S6: Quality Control

[0023] The pills are dark brown to brown, with a smooth surface, no cracks, a slight fragrance, and a slightly bitter taste. The content of crocodile polypeptide is ≥15mg / g, astragaloside IV is ≥0.3mg / g, and the total number of aerobic bacteria is ≤10 3 CFU / g, mold and yeast ≤10 2 CFU / g, no Escherichia coli shall be detected.

[0024] Preferably, in step S11, the frozen crocodile meat and bones are stored below -18°C, and the meat and bones are crushed into particles ≤ 2 mm using a grinder, and then passed through a 40-mesh sieve for later use.

[0025] Preferably, the detailed low-temperature extraction step in step S12 is: mixing the crushed material with purified water at a ratio of 1:5 (w / v), adding 0.1% food-grade protease, adjusting the pH to 7.0, enzymolysis at 45°C for 3 hours, then heating to 90°C to inactivate the enzyme for 10 minutes, cooling and extracting with supercritical CO2 at a pressure of 25 MPa and a temperature of 40°C to extract the fat-soluble components, and collecting the extract; the aqueous phase is filtered through a ceramic membrane to form a filtrate with a molecular weight cutoff of 10 kDa, retaining small molecule peptides and free amino acids, wherein the food-grade protease includes papain.

[0026] Preferably, the detailed post-concentration freeze-drying step in step S12 is: combining the above-mentioned extract and filtrate, concentrating under reduced pressure to 1 / 5 of the original volume, adding 5% maltodextrin and spray drying, at this time the inlet air temperature is 160°C, the outlet air temperature is 80°C, and a light yellow powder is obtained with a moisture content of ≤5%.

[0027] As a preference, in step S22, the supernatant is centrifuged at a speed of 3000 r / min for 15 min; the density of the dark brown thick paste of Chinese medicine is ≥1.3 g / cm 3 .

[0028] Preferably, in step S3, after the medicine powders are mixed, the moisture content of the mixed powder is detected to be ≤8%.

[0029] Preferably, in step S4, the ratio of drug powder to adhesive is 10:1.2; a fully automatic pill making machine is used to control the pill weight difference to be ≤±5%; the pills are spread flat on a stainless steel plate and dried using 40-50°C hot air circulation to a moisture content of ≤6%, avoiding direct sunlight.

[0030] The invention has the following beneficial effects: the crocodile polypeptide in the cancer prevention, control and hypoglycemic drug formula has an immunomodulatory effect, enhances the activity of macrophages and NK cells, and inhibits the proliferation and metastasis of tumor cells; tanshinone and astragaloside IV block tumor growth by inducing tumor cell apoptosis and inhibiting angiogenesis; mulberry leaves and bitter melon powder are rich in flavonoids and polysaccharides, have antioxidant and anti-inflammatory effects, and reduce the risk of tumor occurrence; D-chiro-inositol in black buckwheat and flavonoids in corn silk can improve insulin resistance and lower blood sugar; puerarin and rehmannia polysaccharide promote pancreatic beta cell regeneration and increase insulin secretion; atractylodes and scrophularia: regulate intestinal flora, improve metabolic disorders, and indirectly assist in hypoglycemic and anti-cancer effects;

[0031] The crocodile extract and traditional Chinese medicine in this formula are both naturally derived, with no chemically synthesized drug residues. Its long-term safety is superior to traditional sulfonylureas, metformin, and others. Low-temperature extraction and supercritical CO2 extraction techniques maximize the retention of active ingredients and reduce the formation of harmful substances. Compared with traditional hypoglycemic drugs such as sulfonylureas, this formula regulates blood sugar through multiple pathways, avoiding hypoglycemia caused by a single mechanism. Ingredients such as astragalus and salvia miltiorrhiza can enhance immunity and reduce the risk of infection during chemotherapy or hypoglycemic treatment.

[0032] The raw materials of the formula are mostly common Chinese medicinal materials and artificially farmed crocodiles. The cost is lower than new hypoglycemic drugs such as GLP-1 receptor agonists and DPP-4 inhibitors. Through multi-target effects, it reduces the need for combined medication and lowers overall treatment costs. The formula is aimed at both lowering blood sugar and fighting cancer, and is suitable for patients with diabetes who are at risk of tumors or who have already developed tumors. Crocodile peptides and traditional Chinese medicine ingredients can enhance immunity, reduce the risk of postoperative recurrence, and promote recovery. DETAILED DESCRIPTION

[0033] The present invention will be further described below with reference to the embodiments.

[0034] Example 1

[0035] The present invention provides an embodiment: a cancer prevention, control and hypoglycemic drug formula using a crocodile extract and traditional Chinese medicine, comprising the following components: 50g of crocodile meat and bone extract, 25g of raw astragalus, 25g of raw rehmannia, 15g of atractylodes, 30g of figwort, 10g of kudzu root, 25g of salvia miltiorrhiza, 100g of black tartary buckwheat flour, 20g of corn silk, 30g of wax gourd seed powder, 20g of mulberry leaf and 10g of bitter melon powder;

[0036] Crocodile meat and bone extracts are made from artificially farmed crocodiles, including Siamese crocodiles and saltwater crocodiles, and the meat and bones are taken from individuals that died naturally.

[0037] Black buckwheat flour is cooked black buckwheat flour.

[0038] The preparation steps are as follows:

[0039] S1: Preparation of crocodile extract

[0040] S11: taking frozen crocodile meat and bones, thawing them in running water, washing them, removing surface impurities, and crushing them. The frozen crocodile meat and bones are stored below -18°C, crushed into particles ≤ 2 mm using a grinder, and passed through a 40-mesh sieve for later use;

[0041] S12: Using low-temperature extraction technology to extract the active ingredients, filtering, concentrating and then freeze-drying to obtain crocodile extract powder;

[0042] The detailed low-temperature extraction steps are as follows: the crushed material is mixed with purified water at a ratio of 1:5 (w / v), 0.1% food-grade protease is added, the pH is adjusted to 7.0, and enzymatic hydrolysis is carried out at 45°C for 3 hours, followed by heating to 90°C for 10 minutes to inactivate the enzyme. After cooling, supercritical CO2 extraction is performed at a pressure of 25 MPa and a temperature of 40°C to extract the fat-soluble components, and the extract is collected; the aqueous phase is filtered through a ceramic membrane with a molecular weight cut-off of 10 kDa to obtain a filtrate, retaining small molecule peptides and free amino acids, wherein the food-grade protease includes papain;

[0043] The detailed post-concentration freeze-drying steps are as follows: combining the extract and the filtrate, concentrating under reduced pressure to 1 / 5 of the original volume, adding 5% maltodextrin and spray drying at an inlet air temperature of 160°C and an outlet air temperature of 80°C to obtain a light yellow powder with a moisture content of ≤5%;

[0044] S2: Chinese herbal medicine extraction

[0045] S21: Weigh raw astragalus, raw rehmannia, atractylodes, scrophularia, kudzu root, salvia miltiorrhiza, corn silk, and mulberry leaves in proportion, soak in 8 times the amount of water for 1 hour, bring to a boil over high heat, then simmer over low heat for 1.5 hours, twice in total, and combine the decoctions;

[0046] S22: After filtering the decoction, the decoction is concentrated under reduced pressure at 60°C to a relative density of 1.2-1.3, 95% ethanol is slowly added until the alcohol content reaches 60%, and the decoction is allowed to stand at 4°C for 24 hours. The supernatant is centrifuged and the ethanol is recovered and concentrated until there is no alcohol smell, thereby obtaining a dark brown thick paste of traditional Chinese medicine. The centrifugal speed for the supernatant is 3000 r / min and the time is 15 minutes. The density of the dark brown thick paste of traditional Chinese medicine is ≥1.3 g / cm 3 ;

[0047] S3: Powder mixing

[0048] Place crocodile extract powder, Chinese medicine paste, black buckwheat powder, wax gourd seed powder, and bitter melon powder in a mixer, stir at 15 r / min for 20 minutes, sieve through an 80-mesh sieve to remove lumps, and after the powders are mixed, test the water content of the mixed powder to ensure it is ≤8%;

[0049] S4: Made into pill shape

[0050] The drug powder is made into a soft material using an appropriate amount of water or honey as a binder. The material is then made into pills with a diameter of 5mm-6mm using a pill-making machine. The pills are then dried at 40-50°C to prevent high temperatures from damaging the active ingredients. The ratio of drug powder to binder is 10:1.2. The pill-making machine is fully automatic, and the pill weight variance is controlled to ≤±5%. The pills are then spread flat on a stainless steel plate and dried using a 40-50°C hot air circulation system to a moisture content of ≤6%, avoiding direct sunlight.

[0051] S5: Packaging and Storage

[0052] Put the pills into a sealed bottle or aluminum foil bag and store them in a dark, dry and cool place to prevent them from moisture and oxidation and extend the shelf life.

[0053] S6: Quality Control

[0054] The pills are dark brown to brown, with a smooth surface, no cracks, a slight fragrance, and a slightly bitter taste. The content of crocodile polypeptide is ≥15mg / g, astragaloside IV is ≥0.3mg / g, and the total number of aerobic bacteria is ≤10 3 CFU / g, mold and yeast ≤10 2 CFU / g, no Escherichia coli shall be detected.

[0055] Example 2

[0056] The present invention provides an embodiment: a cancer prevention, control and hypoglycemic drug formula using a crocodile extract and traditional Chinese medicine, comprising the following components: 100g of crocodile meat and bone extract, 50g of raw astragalus, 50g of raw rehmannia, 45g of atractylodes, 60g of figwort, 35g of kudzu root, 50g of salvia miltiorrhiza, 300g of black buckwheat flour, 50g of corn silk, 60g of wax gourd seed powder, 50g of mulberry leaf and 35g of bitter melon powder;

[0057] Crocodile meat and bone extracts are made from artificially farmed crocodiles, including Siamese crocodiles and saltwater crocodiles, and the meat and bones are taken from individuals that died naturally.

[0058] Black buckwheat flour is cooked black buckwheat flour.

[0059] The preparation steps are as follows:

[0060] S1: Preparation of crocodile extract

[0061] S11: taking frozen crocodile meat and bones, thawing them in running water, washing them, removing surface impurities, and crushing them. The frozen crocodile meat and bones are stored below -18°C, crushed into particles ≤ 2 mm using a grinder, and passed through a 40-mesh sieve for later use;

[0062] S12: Using low-temperature extraction technology to extract the active ingredients, filtering, concentrating and then freeze-drying to obtain crocodile extract powder;

[0063] The detailed low-temperature extraction steps are as follows: the crushed material is mixed with purified water at a ratio of 1:5 (w / v), 0.1% food-grade protease is added, the pH is adjusted to 7.0, and enzymatic hydrolysis is carried out at 45°C for 3 hours, followed by heating to 90°C for 10 minutes to inactivate the enzyme. After cooling, supercritical CO2 extraction is performed at a pressure of 25 MPa and a temperature of 40°C to extract the fat-soluble components, and the extract is collected; the aqueous phase is filtered through a ceramic membrane with a molecular weight cut-off of 10 kDa to obtain a filtrate, retaining small molecule peptides and free amino acids, wherein the food-grade protease includes papain;

[0064] The detailed post-concentration freeze-drying steps are as follows: combining the extract and the filtrate, concentrating under reduced pressure to 1 / 5 of the original volume, adding 5% maltodextrin and spray drying at an inlet air temperature of 160°C and an outlet air temperature of 80°C to obtain a light yellow powder with a moisture content of ≤5%;

[0065] S2: Chinese herbal medicine extraction

[0066] S21: Weigh raw astragalus, raw rehmannia, atractylodes, scrophularia, kudzu root, salvia miltiorrhiza, corn silk, and mulberry leaves in proportion, soak in 8 times the amount of water for 1 hour, bring to a boil over high heat, then simmer over low heat for 1.5 hours, twice in total, and combine the decoctions;

[0067] S22: After filtering the decoction, the decoction is concentrated under reduced pressure at 60°C to a relative density of 1.2-1.3, 95% ethanol is slowly added until the alcohol content reaches 60%, and the decoction is allowed to stand at 4°C for 24 hours. The supernatant is centrifuged and the ethanol is recovered and concentrated until there is no alcohol smell, thereby obtaining a dark brown thick paste of traditional Chinese medicine. The centrifugal speed for the supernatant is 3000 r / min and the time is 15 minutes. The density of the dark brown thick paste of traditional Chinese medicine is ≥1.3 g / cm 3 ;

[0068] S3: Powder mixing

[0069] Place crocodile extract powder, Chinese medicine paste, black buckwheat powder, wax gourd seed powder, and bitter melon powder in a mixer, stir at 15 r / min for 20 minutes, sieve through an 80-mesh sieve to remove lumps, and after the powders are mixed, test the water content of the mixed powder to ensure it is ≤8%;

[0070] S4: Made into pill shape

[0071] The drug powder is made into a soft material using an appropriate amount of water or honey as a binder. The material is then made into pills with a diameter of 5mm-6mm using a pill-making machine. The pills are then dried at 40-50°C to prevent high temperatures from damaging the active ingredients. The ratio of drug powder to binder is 10:1.2. The pill-making machine is fully automatic, and the pill weight variance is controlled to ≤±5%. The pills are then spread flat on a stainless steel plate and dried using a 40-50°C hot air circulation system to a moisture content of ≤6%, avoiding direct sunlight.

[0072] S5: Packaging and Storage

[0073] Put the pills into a sealed bottle or aluminum foil bag and store them in a dark, dry and cool place to prevent them from moisture and oxidation and extend the shelf life.

[0074] S6: Quality Control

[0075] The pills are dark brown to brown, with a smooth surface, no cracks, a slight fragrance, and a slightly bitter taste. The content of crocodile polypeptide is ≥15mg / g, astragaloside IV is ≥0.3mg / g, and the total number of aerobic bacteria is ≤10 3 CFU / g, mold and yeast ≤10 2CFU / g, no Escherichia coli shall be detected.

[0076] Experimental example

[0077] The common traditional cancer prevention, control and hypoglycemic drug formulas on the market in Examples 1 and 2 as Experimental Examples 1 and 2 and Experimental Example 3 were divided into three groups for experimental treatment. The traditional cancer prevention, control and hypoglycemic drug formula used sulfonylurea hypoglycemic drugs combined with conventional anticancer drugs;

[0078] A total of 150 patients with diabetes and a high risk of cancer or those who had already developed mild cancer were selected as experimental subjects and randomly divided into three groups of 50 patients each. No significant differences were observed among the three groups in terms of age, gender, and disease severity.

[0079] The experimental period is 3 months, during which patients' blood sugar levels, tumor marker levels, liver and kidney function indicators, and adverse reactions are regularly monitored;

[0080] Collect blood glucose levels and tumor marker levels before and after the experiment, such as CEA and CA199, and test liver and kidney function indicators, such as ALT, AST, BUN, and Cr, and record any adverse reactions;

[0081] The above experimental data are as follows:

[0082]

[0083] Experimental results show that the formula of the present invention is superior to the traditional formula in lowering blood sugar levels, tumor marker levels, and protecting liver and kidney functions, and has a lower incidence of adverse reactions. Therefore, the formula of the present invention has more significant therapeutic effects and higher safety, and is worthy of further promotion and application.

Claims

1. A cancer prevention, control and hypoglycemic drug formula combining crocodile extract and traditional Chinese medicine, characterized in that: The invention comprises the following components: crocodile meat, bone extract 50-100g, raw astragalus 25-50g, raw rehmannia glutinosa 25-50g, atractylodes lancea 15-45g, figwort 30-60g, kudzu root 10-35g, salvia miltiorrhiza 25-50g, black tartary buckwheat powder 100-300g, corn silk 20-50g, wax gourd seed powder 30-60g, mulberry leaf 20-50g and bitter melon powder 10-35g.

2. The cancer prevention, control and hypoglycemic drug formula comprising crocodile extract and traditional Chinese medicine according to claim 1, characterized in that: Crocodile meat and bone extracts are made from artificially farmed crocodiles, including Siamese crocodiles and saltwater crocodiles, and the meat and bones are taken from individuals that died naturally.

3. The cancer prevention, control and hypoglycemic drug formula comprising crocodile extract and traditional Chinese medicine according to claim 1, characterized in that: Black buckwheat flour is cooked black buckwheat flour.

4. The cancer prevention, control and hypoglycemic drug formula comprising crocodile extract and traditional Chinese medicine according to claim 1, wherein the preparation steps are as follows: S1: Preparation of crocodile extract S11: Take frozen crocodile meat and bones, thaw them in running water, wash them, remove surface impurities, and grind them; S12: Using low-temperature extraction technology to extract the active ingredients, filtering, concentrating and then freeze-drying to obtain crocodile extract powder; S2: Chinese herbal medicine extraction S21: Weigh raw astragalus, raw rehmannia, atractylodes, scrophularia, kudzu root, salvia miltiorrhiza, corn silk, and mulberry leaves in proportion, soak in 8 times the amount of water for 1 hour, bring to a boil over high heat, then simmer over low heat for 1.5 hours, twice in total, and combine the decoctions; S22: After filtering the decoction, the decoction is concentrated under reduced pressure at 60°C to a relative density of 1.2-1.3, 95% ethanol is slowly added until the alcohol content reaches 60%, and the decoction is allowed to stand at 4°C for 24 hours. The supernatant is centrifuged and the ethanol is recovered and further concentrated until there is no alcohol smell, thereby obtaining a dark brown thick paste of traditional Chinese medicine; S3: Powder mixing Put crocodile extract powder, Chinese medicine paste, black buckwheat powder, wax gourd seed powder and bitter melon powder into a mixer, stir at 15 r / min for 20 minutes, and pass through an 80-mesh sieve to remove lumps; S4: Made into pill shape Using an appropriate amount of water or honey as a binder, the powder is made into a soft material, which is then made into pills with a diameter of 5mm-6mm using a pill making machine. The pills are then dried at a low temperature of 40-50°C to prevent high temperatures from destroying the active ingredients. S5: Packaging and Storage Put the pills into a sealed bottle or aluminum foil bag and store them in a dark, dry and cool place to prevent them from moisture and oxidation and extend the shelf life. S6: Quality Control The pills are dark brown to brown, with a smooth surface, no cracks, a slight fragrance, and a slightly bitter taste. The content of crocodile polypeptide is ≥15mg / g, astragaloside IV is ≥0.3mg / g, and the total number of aerobic bacteria is ≤10 3 CFU / g, mold and yeast ≤10 2 CFU / g, no Escherichia coli shall be detected.

5. The cancer prevention, control and hypoglycemic drug formula comprising crocodile extract and traditional Chinese medicine according to claim 4, characterized in that: In step S11, the frozen crocodile meat and bones are stored below -18°C, and the meat and bones are crushed into particles ≤ 2 mm using a grinder, and then passed through a 40-mesh sieve for later use.

6. The cancer prevention, control and hypoglycemic drug formula comprising crocodile extract and traditional Chinese medicine according to claim 4, characterized in that: The detailed low-temperature extraction steps in step S12 are as follows: mixing the crushed material with purified water at a ratio of 1:5 (w / v), adding 0.1% food-grade protease, adjusting the pH to 7.0, enzymolysis at 45°C for 3 hours, then heating to 90°C to inactivate the enzyme for 10 minutes, cooling, and extracting with supercritical CO2 at a pressure of 25 MPa and a temperature of 40°C to extract the fat-soluble components, and collecting the extract; the aqueous phase is filtered through a ceramic membrane to form a filtrate with a molecular weight cutoff of 10 kDa, retaining small molecule peptides and free amino acids, wherein the food-grade protease includes papain.

7. The cancer prevention, control and hypoglycemic drug formula comprising crocodile extract and traditional Chinese medicine according to claim 5, characterized in that: The detailed post-concentration freeze-drying steps in step S12 are as follows: combining the above extract and filtrate, concentrating under reduced pressure to 1 / 5 of the original volume, adding 5% maltodextrin and spray drying at this time, at which time the inlet air temperature is 160°C and the outlet air temperature is 80°C, to obtain a light yellow powder with a moisture content of ≤5%.

8. The cancer prevention, control and hypoglycemic drug formula comprising crocodile extract and traditional Chinese medicine according to claim 4, characterized in that: In step S22, the supernatant was centrifuged at a speed of 3000 r / min for 15 min; the density of the dark brown thick paste of Chinese medicine was ≥1.3 g / cm 3 .

9. The cancer prevention, control and hypoglycemic drug formula comprising crocodile extract and traditional Chinese medicine according to claim 4, characterized in that: In step S3, after the powder mixture is mixed, the moisture content of the mixed powder is detected to be ≤8%.

10. The cancer prevention, control and hypoglycemic drug formula comprising crocodile extract and traditional Chinese medicine according to claim 4, characterized in that: In step S4, the ratio of drug powder to adhesive is 10:1.2; a fully automatic pill making machine is used to control the pill weight difference to ≤±5%; the pills are spread flat on a stainless steel plate and dried using 40-50°C hot air circulation to a moisture content of ≤6%, avoiding direct sunlight.

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