Synergistic antibacterial bio-based polyurethane foam material and preparation method thereof
By introducing curcumin and isothiazolinone derivatives as synergistic antibacterial agents into polyurethane foaming materials, a multi-component synergistic antibacterial network was constructed, and the problem of insufficient antibacterial performance of existing polyurethane foaming materials was solved, and the synergistic effect of high biological activity and high antibacteriality was achieved, and the antibacterial durability and stability of the material was improved.
Patent Information
- Application Number
- CN202510762311.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-09
- Publication Date
- 2025-08-08
AI Technical Summary
The existing polyurethane foaming materials have problems such as easy antibacterial agents to fall off, short antibacterial age, and poor heat resistance and stability in terms of antibacterial properties, which limit their wide application in the field of life and health, and single antibacterial agents show performance limitations in complex microbial environments.
Curcumin and isothiazolinone derivatives are used as synergistic antibacterial agents to regulate the distribution in the polyurethane chain through stoichiometric regulation, and a multi-component synergistic antibacterial system is constructed, and the high biological activity of curcumin and the high antibacterial properties of isothiazolinone are used to form a stable antibacterial network.
The synergistic effect of high biological activity and high antibacterial properties was achieved, and antibacterial bio-based polyurethane foaming material with uniform structure and excellent performance was prepared, which solved the shortcomings of a single antibacterial agent, reduced the risk of human skin allergy, and improved the antibacterial durability and stability of the material.
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Figure CN120441805A_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the field of chemistry, and in particular to a synergistic antibacterial bio-based polyurethane foam material and a preparation method thereof. Background Art
[0002] In recent years, the application of polyurethane materials in healthcare, food packaging, and industry has attracted widespread attention from researchers. However, due to the porosity and hygroscopic properties of polyurethane foam, its surface is highly susceptible to bacterial growth and reproduction. This not only causes the material to discolor and affect its appearance, but also can cause microbial corrosion, leading to material fracture, performance loss, and shortened service life, posing a potential threat to the environment and human health. Against this backdrop, the antimicrobial functionalization of polyurethane foam materials is of great significance for protecting human health, and its development is gaining increasing attention in the industry.
[0003] The preparation of existing antimicrobial polyurethane foam materials typically relies on the addition of one or more antimicrobial agents during the formulation process to achieve an antimicrobial effect. However, the antimicrobial properties of these materials are easily affected by the antimicrobial agent's heat resistance, acidity, and alkalinity, leading to common technical bottlenecks such as easy antimicrobial agent shedding, short antimicrobial duration, and poor thermal stability. Furthermore, the toxicity of the added antimicrobial agents has prevented widespread application of polyurethane foam materials in the healthcare sector.
[0004] Moreover, faced with the need for antibacterial effects in complex microbial environments, the performance limitations of single antibacterial agents have prompted researchers to turn to the development of synergistic antibacterial systems. The antibacterial mechanism of curcumin against Gram-positive bacteria (destroying cell membranes) and the action pathway of isothiazolinone against Gram-negative bacteria (inhibiting enzyme activity) are significantly complementary. The two can synergize to form a "multi-target" antibacterial network, broaden the antibacterial spectrum and reduce the dosage of a single ingredient. Based on the research on a single component, curcumin and isothiazolinone derivatives were innovatively introduced into the polyurethane foam material system. By regulating the ratio and bonding method of the two, a multi-component synergistic antibacterial bio-based polyurethane foam material was constructed.
[0005] Therefore, there is an urgent need to develop a method for preparing an antibacterial bio-based polyurethane foam material that has both high biological activity and high antibacterial properties. Summary of the Invention
[0006] This invention aims to overcome the limitations of existing materials that possess high bioactivity but weak antimicrobial properties, or vice versa, by providing a novel synergistic antimicrobial bio-based polyurethane foam material and its preparation method. This research first optimizes the distribution of the two components within the polyurethane chain through stoichiometric manipulation. Curcumin and an isothiazolinone derivative are then used as chain extenders in the polyurethane foam material, imparting antimicrobial properties. This creates a design strategy for a "natural-synthetic" synergistic antimicrobial system.
[0007] In order to achieve the above object, the present invention adopts the following technical solutions:
[0008] The synergistic ratio of curcumin / isothiazolinone derivatives provided by the present invention is regulated as follows:
[0009]
[0010] In a first aspect, the present application provides a synergistic antimicrobial bio-based polyurethane foam material, characterized in that the antimicrobial bio-based polyurethane foam material is prepared by foaming a first raw material component and a second raw material component, and a third component is used to complete the demoulding molding of the material;
[0011] Calculated by weight, the first raw material component comprises:
[0012]
[0013] Calculated by weight, the first raw material component comprises:
[0014] 30-40 parts of isocyanate
[0015] In a specific embodiment, based on 100 parts by weight of the polyether polyol contained in the first raw material component, the first raw material component may contain 0.25, 0.30, 0.35, 0.40, 0.45, 0.50 parts by weight or a range or sub-range between any two of these values of the synergistic combination antibacterial agent.
[0016] In one embodiment of the first aspect, the antibacterial bio-based polyurethane foam material is prepared by subjecting the first raw material component and the second raw material component to a one-step foaming molding process.
[0017] In one embodiment of the first aspect, the polyether polyol is polyoxypropylene triol and / or polyoxypropylene-oxyethylene glycol.
[0018] In one embodiment of the first aspect, the types of synergistic antibacterial agents are divided into two categories, one is curcumin, and the other is isothiazolinone derivative antibacterial agents, including 2-hydroxymethylbenzisothiazolinone (HMBIT), N-(1,3-dihydroxy-2-methylprop-2-yl)-2-(benzisothiazolin-3-one-2-yl)acetamide (BITAC-AMPD), N-(1,3-dihydroxy-2-(hydroxymethyl)prop-2-yl)-2-(benzisothiazolin-2-yl)acetamide (BITAC-TOH), and (benzisothiazolin-3-one-2-yl)acetic acid (BITAC). One or more.
[0019] In one embodiment of the first aspect, the catalyst is a tertiary amine catalyst, an organometallic compound catalyst or a mixture thereof.
[0020] In one embodiment of the first aspect, the catalyst is an amine-metal composite catalyst.
[0021] In one embodiment of the first aspect, the surfactant is a silicone oil surfactant, preferably DC-193, KF-6011 or a mixture thereof.
[0022] In one embodiment of the first aspect, the chemical foaming agent is water.
[0023] In one embodiment of the first aspect, the isocyanate is a diisocyanate, a polyisocyanate or a mixture thereof.
[0024] In one embodiment of the first aspect, the isocyanate is one or more of phorone diisocyanate, toluene diisocyanate, toluene diisocyanate 80, diphenylmethane diisocyanate and hexamethylene diisocyanate.
[0025] In one embodiment of the first aspect, the method comprises the following steps:
[0026] (1) Preparation of the first component:
[0027] Weigh the polyether polyol, catalyst, chemical foaming agent, surfactant, and synergistic antibacterial agent in different proportions according to the proportions described in claim 1, add them into a container, and stir to uniformly mix the raw materials in the container to obtain a first component;
[0028] (2) Preparation of synergistic antibacterial bio-based polyurethane foam materials:
[0029] Weigh isocyanate as the second component according to the ratio of claim 1, add it to the first component, stir, quickly pour the mixture into a mold for foaming, and mature it at room temperature to obtain an antibacterial polyurethane foam material.
[0030] Compared with the prior art, the present invention has the following obvious outstanding substantial features and significant advantages:
[0031] 1. The present invention adopts a method of two antibacterial agents working together and interacting with each other, utilizing the high biological activity of curcumin and the high antibacterial properties of isothiazolinone derivatives to obtain an antibacterial bio-based polyurethane foam material with high biological activity and high antibacterial properties.
[0032] 2. The antibacterial bio-based polyurethane foam material prepared by the present invention uses curcumin and isothiazolinone compounds that can be bonded with isocyanate as antibacterial agents, and silicone oil as a surfactant. It can stabilize the pore structure and adjust the pore size, improve the mutual solubility between the mixed materials, and thus prepare a foam product with uniform structure and excellent performance. The preparation process of this material is simple and low-cost.
[0033] 3. The antibacterial bio-based polyurethane foam material prepared by the present invention can overcome problems such as human skin allergies caused by high concentrations of a single drug. BRIEF DESCRIPTION OF THE DRAWINGS
[0034] Figure 1 This is the inhibition zone picture of Example 1, where a represents Escherichia coli and b represents Staphylococcus aureus.
[0035] Figure 2 This is the inhibition zone picture of Example 2, where a represents Escherichia coli and b represents Staphylococcus aureus.
[0036] Figure 3 This is the inhibition zone picture of Example 3, where a represents Escherichia coli and b represents Staphylococcus aureus.
[0037] Figure 4 These are optical microscope images of antibacterial polyurethane foam materials with different isothiazolinone antibacterial agents added.
[0038] Figure 5 The infrared spectra of polyurethane foam materials with different antimicrobial agents added are shown in Figure 2. Figure 5 In the figure, curve a represents the polyurethane foam material without adding an antibacterial agent; curve b represents the added antibacterial agent is HMBIT, curve c represents the added antibacterial agent is BITAC-AMPD, and curve d represents the added antibacterial agent is BITAC-TOH. DETAILED DESCRIPTION
[0039] Unless otherwise indicated, implied from the context, or customary in the art, all parts and percentages in this application are based on weight, and the test and characterization methods used are current as of the filing date of this application. Where applicable, the contents of any patents, patent applications, or publications referred to in this application are incorporated herein by reference in their entirety, and their equivalent patent families are also incorporated by reference, especially with respect to definitions of synthetic techniques, product and processing designs, polymers, comonomers, initiators, or catalysts disclosed in these documents in the art. If the definition of a specific term disclosed in the prior art is inconsistent with any definition provided in this application, the definition of the term provided in this application shall prevail.
[0040] Numerical ranges in this application are approximate values, so unless otherwise stated, they may include numerical values outside the range. Numerical ranges include all numerical values from the lower limit to the upper limit increased by 1 unit, provided that there is an interval of at least 2 units between any lower value and any higher value. For example, if the recorded component, physical or other properties (such as molecular weight, melt index, etc.) are 100 to 1000, it is meant that all individual numerical values are clearly enumerated, such as 100, 101, 102, etc., and all subranges, such as 100 to 166, 155 to 170, 198 to 200, etc. For a range comprising a numerical value less than 1 or comprising a fraction greater than 1 (such as 1.1, 1.5, etc.), 1 unit is appropriately considered to be 0.0001, 0.001, 0.01 or 0.1. For a range comprising a single digit less than 10 (such as 1 to 5), 1 unit is typically considered to be 0.1. These are merely specific examples of what is intended, and all possible combinations of values between the lowest and highest values recited are considered to be expressly stated in this application. It should also be noted that the terms "first," "second," etc. herein do not limit the order of precedence, but are only used to distinguish substances of different structures.
[0041] When used with respect to chemical compounds, unless expressly stated otherwise, the singular includes all isomeric forms and vice versa (e.g., "hexane" includes all isomers of hexane, individually or collectively). In addition, nouns using "a," "an," or "the" also include their plural forms unless expressly stated otherwise.
[0042] The terms "comprising", "including", "having" and their derivatives do not exclude the presence of any other components, steps or processes and are irrelevant to whether these other components, steps or processes are disclosed in this application. To eliminate any doubt, all compositions using the terms "comprising", "including", or "having" in this application may include any additional additives, excipients or compounds unless expressly stated otherwise. In contrast, the term "essentially consisting of" excludes any other components, steps or processes from the scope of any description of the term below, except those necessary for operational performance. The term "consisting of" does not include any components, steps or processes that are not specifically described or listed. Unless expressly stated otherwise, the term "or" refers to the listed members alone or in any combination thereof.
[0043] The following examples will be used to clearly and completely describe the technical solutions of the present application. Unless otherwise specified, all reagents and raw materials used can be purchased from commercial sources. The experimental methods in the following examples, where specific conditions are not specified, were performed according to conventional methods and conditions, or selected according to the product specifications.
[0044] Example
[0045] Preparation Example of Synergistic Antibacterial Bio-based Antibacterial Polyurethane Foam Material
[0046] Example 1
[0047] Preparation of an isothiazolinone derivative antibacterial polyurethane foam material (corresponding to Group A)
[0048] Example 1 involves the preparation of an antibacterial bio-based polyurethane foam material modified with only an isothiazolinone derivative.
[0049] The raw material ratio of Example 1 is as shown in Table 1 below, and the units in Table 1 are parts by weight.
[0050] Table 1 Raw material ratio of Example 1 (unit is weight part)
[0051]
[0052]
[0053] The specific steps of Example 1 are as follows:
[0054] (1) preparing a first raw material component: mixing a polyether polyol, a catalyst, a foaming agent, a foaming stabilizer, and three isothiazolinone derivatives in proportion, adding the mixture to a container, and stirring the mixture at room temperature for about 60 seconds at a speed of 2000 rpm using a high-speed stirrer to uniformly mix the raw materials in the container to obtain a first raw material component, wherein the amount of curcumin added is 0 part, 0.2 part, 0.5 part, 0.8 part, 1.0 part, 1.3 parts, and 1.5 parts, respectively;
[0055] (2) Preparation of antimicrobial polyurethane foam: Toluene diisocyanate (TDI) was weighed as the second raw material component and added to the first raw material component. The mixture was stirred at 2000 rpm for approximately 30 seconds. The mixture was then quickly poured into a mold for foaming. After aging at room temperature for 24 hours, the antimicrobial bio-based polyurethane foam was obtained.
[0056] Example 2
[0057] Preparation of a curcumin / isothiazolinone derivative antibacterial bio-based polyurethane foam material (corresponding to Group B, Group C, Group D)
[0058] Example 2 involves modified antibacterial bio-based polyurethane foam materials comprising curcumin: HMBIT / BITAC-AMPD / BITAC-TOH = 1:3, curcumin: HMBIT / BITAC-AMPD / BITAC-TOH = 1:1, and curcumin: HMBIT / BITAC-AMPD / BITAC-TOH = 3:1. The raw material ratios for Example 2 are shown in Table 2 below, where the units in Table 2 are parts by weight.
[0059] Table 2 Raw material ratio of embodiment 2 (unit is weight part)
[0060]
[0061]
[0062] The specific steps of Example 2 are as follows:
[0063] (1) preparing a first raw material component: mixing polyether polyol, catalyst, foaming agent, foaming stabilizer, curcumin: HMBIT / BITAC-AMPD / BITAC-TOH=1:3, curcumin: HMBIT / BITAC-AMPD / BITAC-TOH=1:1, and curcumin: HMBIT / BITAC-AMPD / BITAC-TOH=3:1 in a certain proportion, adding the mixture to a container, and stirring the mixture at room temperature for about 60 seconds at a speed of 2000 rpm with a high-speed stirrer to uniformly mix the raw materials in the container to obtain a first raw material component, wherein the total amount of curcumin / HMBIT (1:3) added is 0 part, 0.2 part, 0.5 part, 0.8 part, 1.0 part, 1.3 parts, and 1.5 parts, respectively;
[0064] (2) Preparation of an antimicrobial bio-based polyurethane foam: Toluene diisocyanate (TDI) was weighed as the second raw material component and added to the first raw material component. The mixture was stirred at 2000 rpm for approximately 30 seconds. The mixture was then quickly poured into a mold for foaming. After aging at room temperature for 24 hours, an antimicrobial bio-based polyurethane foam was obtained.
[0065] Example 3
[0066] Preparation of a curcumin antibacterial polyurethane foam material (corresponding to Group E)
[0067] Example 3 involves the preparation of curcumin modified antibacterial bio-based polyurethane foam material. The raw material ratio of Example 2 is as shown in Table 3 below, and the units in Table 3 are parts by weight.
[0068] Table 3 Raw material ratio of Example 3 (unit is weight part)
[0069]
[0070]
[0071] The specific steps of Example 3 are as follows:
[0072] (1) preparing a first raw material component: mixing a polyether polyol, a catalyst, a foaming agent, a foaming stabilizer, and curcumin in proportion, adding the mixture to a container, and stirring the mixture at room temperature for about 60 seconds at a speed of 2000 rpm with a high-speed stirrer to uniformly mix the raw materials in the container to obtain a first raw material component, wherein the amount of curcumin added is 0.2 parts, 0.5 parts, 0.8 parts, 1.0 parts, 1.3 parts, and 1.5 parts, respectively;
[0073] (2) Preparation of an antimicrobial bio-based polyurethane foam: Toluene diisocyanate (TDI) was weighed as the second raw material component and added to the first raw material component. The mixture was stirred at 2000 rpm for approximately 30 seconds. The mixture was then quickly poured into a mold for foaming. After aging at room temperature for 24 hours, an antimicrobial bio-based polyurethane foam was obtained.
[0074] Performance Characterization Examples
[0075] Using infrared spectroscopy, various bonded antibacterial polyurethane foam materials with an antibacterial agent addition of 1.5% were characterized. The results are shown in Figure 2 Where a is a polyurethane foam material without adding antibacterial agent, Figure 2 You can know 2300-2200cm -1 The -NCO asymmetric stretching vibration absorption peak disappears within the range, 1720cm -1 The stretching vibration absorption peak of -C=O appears at 1720cm -1 The stretching vibration absorption peak of the soft segment ether bond -COC- appears at , indicating that the antibacterial polyurethane foam material was successfully prepared.
[0076] Antibacterial performance characterization
[0077] The OD600 method and inhibition zone method were used to jointly test the antibacterial properties of antibacterial polyurethane.
[0078] OD600 method: Staphylococcus aureus and Escherichia coli were selected, and the absorbance of LB liquid culture at a wavelength of 600nm (OD600) was measured using a UV spectrophotometer to quantify the antibacterial properties of the antibacterial polyurethane foam. 9.9mL of liquid culture medium, 100μL of bacterial suspension, and 0.2g of polyurethane foam were added to a 15mL test tube (the control experiment was the unmodified polyurethane foam Example 1, and the antibacterial agent content was selected to be 4.0%, i.e., Example 5, Example 11, Example 17, and Example 23). The tube was placed in a shaker and cultured at 37°C for 24 hours. The cultured bacterial liquid was sampled and its absorbance at a wavelength of 600nm (OD600) was measured using a UV spectrophotometer. At a wavelength of 600nm, the absorbance of bacteria is linearly related to the bacterial concentration.
[0079] Antibacterial activity was evaluated using the inhibition zone method, where the diameter of the inhibition zone was measured to assess antibacterial activity. The procedure was as follows: Agar wells were prepared under sterile conditions using a 1 mm diameter cork punch (autoclaved at 121°C for 20 min and dried). Before the experiment, the clean bench was sterilized with ultraviolet light for 1 h. 15 mL of molten solid culture medium was poured into the sterilized Petri dishes and allowed to solidify. 100 μL of the two test bacterial suspensions, Staphylococcus aureus and Escherichia coli, was evenly spread onto the corresponding solid culture medium to prepare bacterial plates. The cork punch was placed vertically above the Petri dishes, and holes were quickly punched. 15 μL of antibacterial polyurethane foam material, dissolved at different concentrations, was then dripped into the holes. The inoculated plates were then incubated inverted in a 37°C incubator for 24 h. The diameter of the inhibition zone was measured using the cross-hatch method. Three replicates were performed for each group, and the average was used to assess antibacterial activity. The standard deviation was calculated to enhance data reliability.
[0080] Calculation of antibacterial rate:
[0081] Antibacterial rate = 1-(CA) / (BA)×100%
[0082] The experimental group design is as follows:
[0083] Group A (blank control): 9 mL sterile liquid culture medium + 1000 μL sterile water
[0084] Group B (negative control): 9 mL of third-generation bacterial suspension + 1000 μL of sterile water
[0085] Group C (experimental group): 9 mL of third-generation bacterial suspension + 1000 μL of antibacterial agents of different concentrations (8000, 4000, 2000, 1000, 500 ppm).
[0086] Test results
[0087] Using the OD600 method, the antibacterial rate of antimicrobial polyurethane foam was tested for 24 hours against Staphylococcus aureus and Escherichia coli at a 1.0% mass fraction of the antimicrobial agent. BITAC-AMPD was found to have the highest inhibition rate of 100% among the three isothiazolinone derivatives. Furthermore, the curcumin:isothiazolinone derivative ratio of 1:3 exhibited the best antibacterial effect, with a curcumin:BITAC-AMPD ratio of 1:3 achieving the highest antibacterial effect. The results of the inhibition zone assay were used to validate the OD600 results, and the validation results were consistent with those of the OD600 assay, confirming that BITAC-AMPD exhibited the highest antibacterial activity.
[0088] Table 4 Inhibition rate of different concentrations of antibacterial polyurethane against different dominant bacterial species after culturing for 12 h (%)
[0089]
[0090] Mechanical properties characterization
[0091] Morphology analysis
[0092] The flat surface of the antibacterial bio-based polyurethane foam material cut by a cutter was imaged using an MC-H4800C optical microscope. The instrument observed the pore structure of the material at a magnification of 20 times.
[0093] Mechanical properties testing
[0094] Mechanical properties were measured using a DY-CMDW-10KN universal mechanical testing machine. Using GB / T 6344-2008 as the test standard for tensile strength and elongation at break, the antibacterial polyurethane foam material achieved a maximum tensile strength of 257 kPa and an elongation at break as low as 158%. Using GB / T 10808-2006 as the test standard for tear strength, the tear strength of the antibacterial polyurethane foam material remained stable at 8 N cm⁻¹. Compression set was measured using Method B in GB / T 6669-2008, and rebound resilience was measured using GB / T 6670-2008. Dumbbell-shaped specimens of the three finished CURPU materials were formed into 2 mm thick, 25 mm long, and 6 mm wide strips.
[0095] The present invention designs and synthesizes curcumin and isothiazolinone derivatives to act synergistically as antibacterial agents, explores the formula of antibacterial bio-based polyurethane foam materials, and prepares a synergistic antibacterial bio-based polyurethane foam material with long-lasting broad-spectrum antibacterial effect and low concentration of isothiazolinone derivatives.
[0096] The above description of the embodiments is intended to facilitate understanding and application of the present application by those skilled in the art. It will be apparent that those skilled in the art can readily make various modifications to these embodiments and apply the general principles described herein to other embodiments without expending any creative effort. Therefore, the present application is not limited to the embodiments described herein, and improvements and modifications made by those skilled in the art based on the disclosure of this application without departing from the scope and spirit of this application are within the scope of this application.
Claims
1. A synergistic antibacterial bio-based polyurethane foam material, characterized in that: The bonded antibacterial polyurethane foam material is prepared by foaming a first raw material component and a second raw material component; Calculated by weight, the first raw material component comprises: Based on parts by weight, the second raw material component comprises: 30-40 parts of isocyanate wherein the synergistic antibacterial polyurethane foam material is prepared by subjecting the first raw material component and the second raw material component to a one-step foaming molding process; Among them, the types of synergistic antibacterial agents are divided into two categories, one is curcumin, and the other is isothiazolinone derivative antibacterial agents, including 2-hydroxymethylbenzisothiazolinone (HMBIT), N-(1,3-dihydroxy-2-methylprop-2-yl)-2-(benzisothiazolin-3-one-2-yl)acetamide (BITAC-AMPD), N-(1,3-dihydroxy-2-(hydroxymethyl)prop-2-yl)-2-(benzisothiazolin-2-yl)acetamide (BITAC-TOH), (benzisothiazolin-3-one-2-yl)acetic acid (BITAC), etc. One or more.
2. The synergistic antibacterial bio-based polyurethane foam material according to claim 1, characterized in that: The polyether polyol is polyoxypropylene triol and / or polyoxypropylene-oxyethylene glycol.
3. The synergistic antibacterial bio-based polyurethane foam material according to claim 1, wherein the catalyst is a tertiary amine catalyst, an organometallic compound catalyst or a mixture thereof.
4. The synergistic antibacterial bio-based polyurethane foam material according to claim 3, characterized in that: The catalyst is an amine-metal composite catalyst.
5. The synergistic antibacterial bio-based polyurethane foam material according to claim 1, characterized in that: The surfactant is a silicone oil surfactant.
6. The synergistic antibacterial bio-based polyurethane foam material according to claim 5, characterized in that: The surfactant is DC-193, KF-6011 or a mixture thereof.
7. The synergistic antibacterial bio-based polyurethane foam material according to claim 1, characterized in that: The chemical foaming agent is water.
8. The antibacterial polyurethane foam material according to any one of claims 1 to 7, characterized in that: The isocyanate is diisocyanate, polyisocyanate or a mixture thereof.
9. The synergistic antimicrobial bio-based polyurethane foam material according to claim 8, characterized in that: The isocyanate is one or more of phorone diisocyanate, toluene diisocyanate, toluene diisocyanate 80, diphenylmethane diisocyanate and hexamethylene diisocyanate.
10. The method for preparing the synergistic antibacterial bio-based polyurethane foam material according to claim 1, wherein: The method comprises the following steps: (1) Preparation of the first component: Weigh the polyether polyol, catalyst, chemical foaming agent, surfactant, and synergistic antibacterial agent in different proportions according to the proportions described in claim 1, add them into a container, and stir to uniformly mix the raw materials in the container to obtain a first component; (2) Preparation of synergistic antibacterial bio-based polyurethane foam materials: Weigh isocyanate as the second component according to the ratio described in claim 1, add it to the first component, stir, quickly pour the mixture into a mold for foaming, and obtain an antibacterial polyurethane foam material after aging at room temperature.