Application of red ginseng or red ginseng extract in preparation of product for improving physiological parameters of skin

Abstract

The invention discloses application of red ginseng or red ginseng extract in preparation of a product for improving physiological parameters of skin. Specifically, the improvement of the skin physiological parameters comprises improvement of face qi and blood, improvement of face fine lines, improvement of skin brightness, improvement of cuticle moisture, repair of skin barrier, improvement of skin compactness, improvement of skin elasticity, or improvement of skin gloss.

Description

Technical Field

[0001] The present invention belongs to the technical field of nutritional compositions, and in particular relates to the application of red ginseng or a red ginseng extract in the preparation of products for improving skin physiological parameters. Background Art

[0002] Everyone loves beauty, and good nutrition is the foundation of healthy skin. Studies have found that proper nutritional intake is associated with pleasing skin appearance. A nutritional plan can maintain skin health and delay skin aging.

[0003] There have been many reports on the moisturizing effects of oral hydrolyzed collagen and niacinamide on the skin. However, collagen is mostly derived from animals and its application in food fields such as Halal and Kosher certification is limited. The oral effects of niacinamide and hyaluronic acid are far inferior to those of topical products, and more effective nutritional solutions are urgently needed.

[0004] The skin, covering approximately two square meters and accounting for one-sixth of an adult's total weight, is the body's largest organ. It possesses a highly complex microanatomical structure, comprising several key cell types: keratinocytes, fibroblasts, melanocytes, Merkel cells, and various immune cells (mast cells, migrating monocytes, and Langerhans cells). In addition to skin cells, it also contains sweat glands, hair follicles, and a complex network of capillaries and nerves. Connective tissue, rich in the extracellular matrix, underlies the skin's flexibility.

[0005] Essentially, the epidermis, dermis, and subcutaneous tissue (also called the subcutaneous layer) are the main layers of the skin. The stratified squamous epidermis is capable of self-renewal. The primary epidermal cells are keratinocytes, which originate from the ectoderm during early embryonic development. The dermis, a much thicker layer than the epidermis, consists of the papillary dermis (upper layer) and the reticular dermis (lower layer) and contains fibroblasts.

[0006] The dermis is a layer much thicker than the epidermis, composed of the papillary dermis (upper) and reticular dermis (lower), containing fibroblasts and a complex ECM. Its elastic properties are provided by elastin fibers, while its structural elements are provided by collagen fibers. Between the epidermis and dermis is the dermal-epidermal junction (DEJ), which connects the two layers and acts as a chemical and cellular barrier. The deepest layer of skin, the subcutaneous tissue, lies above the underlying fascia, muscle, and dermis. It contains connective tissue, blood vessels, and fat.

[0007] The skin performs a range of critical functions. It is the front line for protecting the body from external insults and constantly replenishing itself in normal homeostasis. The epidermal barrier plays a well-known protective role at five functional levels: chemical, physical, immune, microbial, and neuronal. In addition, the skin helps maintain a constant body temperature by regulating moisture. It collects sensory signals through nerve endings, secretes sweat, sebum, hormones, and enzymes, and excretes harmful metabolic products from the internal organs. In addition to the anatomical basis of the integumentary system, emerging evidence shows that the skin can produce the same biomolecules as other parts of the body (such as neurotrophins, neuropeptides, hormones, and cytokines) and interact with the system through them, identifying the skin as a "neuro-endocrine-immune" organ.

[0008] In recent years, many studies have evaluated the effects of oral hydrolyzed collagen, niacinamide, anthocyanins, hyaluronic acid, lactic acid bacteria, polyphenols, astaxanthin, and carotenoids on improving skin health. Among them, collagen has been studied more, suggesting that it can increase skin moisture and elasticity and enhance skin barrier function. Others such as niacinamide, hyaluronic acid, and anthocyanins have certain evidence that they can increase skin moisture. Summary of the Invention

[0009] The purpose of the present invention is to provide the use of red ginseng or red ginseng extract in the preparation of products for improving skin physiological parameters. Red ginseng or red ginseng extract can improve human skin physiological parameters, maintain skin health, increase skin brightness, significantly increase the proportion of subcutaneous red area, improve facial skin barrier function, reduce fine lines, increase glossiness, elasticity and firmness, enhance skin barrier function, and reduce skin water loss.

[0010] In order to achieve the above object, the present invention adopts the following technical solutions:

[0011] In one aspect, the present invention provides the use of red ginseng or a red ginseng extract in preparing a product for improving skin physiological parameters.

[0012] According to a specific embodiment of the present invention, the red ginseng extract is an extract obtained by using red ginseng as raw material through a water extraction process.

[0013] According to a specific embodiment of the present invention, the red ginseng extract contains soluble polysaccharides, soluble oligosaccharides, and ginsenosides.

[0014] In the present invention, the ginseng used to make the red ginseng extract can be ginseng from Asia or America, including wild ginseng, forest ginseng, garden ginseng (artificially cultivated ginseng), and other different sources. The daily consumption of red ginseng is no more than 9g dry weight or an equivalent amount of red ginseng extract.

[0015] In the present invention, the active ingredients of the red ginseng extract are as follows:

[0016] The total amount of soluble polysaccharides and / or soluble oligosaccharides accounts for 0.1%-25% of the extract;

[0017] Total ginsenosides account for 0.1mg / g-300mg / g or 0.01%-0.3% of the extract;

[0018] Ginsenoside Rg1 accounts for 0.13 mg / g-60 mg / g or 0.0013%-0.06% of the extract.

[0019] According to a specific embodiment of the present invention, the amount of red ginseng added to the food is 10mg-18g / 100g or 10mg-18g of red ginseng extract.

[0020] In some embodiments, the amount of the red ginseng extract added per 100 g of the product is 10 mg-8 g, 10 mg-7 g, 10 mg-6 g, 10 mg-5 g, 10 mg-4 g, 10 mg-3 g, 10 mg-2 g, 10 mg-1 g, 10 mg-900 mg, 10 mg-800 mg, 10 mg-700 mg, 10 mg-600 mg, 10 mg-500 mg, 10 mg-400 mg, 10 mg-300 mg, 10 mg-200 mg, 10 mg-100 mg, 10 mg-90 mg, 10 mg-80 mg, 10 mg-70 mg 10 mg-60 mg, 10 mg-50 mg, 10 mg-40 mg, 10 mg-30 mg or 10 mg-20 mg.

[0021] According to a specific embodiment of the present invention, the product is a nutritional composition.

[0022] In the present invention, "nutritional composition" can be a liquid, powder, gel, paste, solid, concentrate, suspension or enteral formula, oral formula, pediatric subject formula, children's formula, growing-up milk and / or adult nutritional composition in ready-to-use form.

[0023] According to a specific embodiment of the present invention, the nutritional composition further comprises vitamins, minerals, or water extracts of plants having medicinal and edible properties.

[0024] According to a specific embodiment of the present invention, the medicinal and edible plants include one or more medicinal and edible plants such as longan, wolfberry, red dates, Poria, Codonopsis pilosula, Cistanche deserticola, Dendrobium officinale, American ginseng, Astragalus, Ganoderma lucidum, Sophora japonica seeds, Angelica dahurica, red beans, mulberry leaves, lotus leaves, Perilla frutescens, Pueraria root, ginseng, honeysuckle, chrysanthemum, Sophora japonica flower, rose, saffron, etc.

[0025] According to a specific embodiment of the present invention, the product is food.

[0026] According to a specific embodiment of the present invention, the food includes beverages and dairy products.

[0027] According to a specific embodiment of the present invention, the improvement of skin physiological parameters includes improving facial qi and blood, improving facial fine lines and texture, improving skin brightness, increasing stratum corneum moisture, repairing skin barrier, improving skin firmness, improving skin elasticity, improving skin gloss, or increasing skin temperature.

[0028] On the other hand, the present invention also provides a method for improving skin physiological parameters for non-therapeutic purposes, wherein the method comprises allowing a subject to consume red ginseng or a red ginseng extract.

[0029] According to a specific embodiment of the present invention, the red ginseng extract contains soluble polysaccharides, soluble oligosaccharides, or ginsenosides.

[0030] According to a specific embodiment of the present invention, the improvement of skin physiological parameters includes improving facial qi and blood, improving facial fine lines and texture, improving skin brightness, increasing stratum corneum moisture, repairing skin barrier, improving skin firmness, improving skin elasticity, improving skin gloss, or increasing skin temperature.

[0031] According to a specific embodiment of the present invention, the subject includes a mammal or a human.

[0032] Beneficial effects of the present invention:

[0033] This study evaluated the effects of red ginseng or red ginseng extract on the skin physiological parameters of women with Qi and blood deficiency through a single-arm clinical trial. After 8 weeks of oral intervention, it was found that red ginseng or red ginseng extract can improve multiple skin parameters, achieving the effect of nourishing the skin from the inside out and achieving a more ideal skin condition. Specifically:

[0034] 1. Red ginseng extract improves facial qi and blood. After taking red ginseng extract, the area of red areas on the face increased significantly. The red areas represent the oxygenation level of skin hemoglobin or the state of blood circulation.

[0035] 2. Red ginseng extract increases stratum corneum moisture and repairs the skin barrier. Oral administration of red ginseng extract significantly increased the water content of the skin stratum corneum and decreased the transepidermal water loss rate. This suggests that oral administration of red ginseng extract can improve the facial skin barrier function of volunteers and reduce water loss.

[0036] 3. Red ginseng extract improves facial fine lines and texture. Oral administration of red ginseng extract significantly reduces the count of facial texture features.

[0037] 4. Red ginseng extract improves skin glossiness.

[0038] 5. Red ginseng extract improves skin firmness. Oral administration of red ginseng extract significantly decreased skin firmness parameters. This suggests that oral administration of red ginseng extract can make volunteers' facial skin firmer. Red ginseng extract improves skin elasticity. Oral administration of red ginseng extract significantly increased skin elasticity. This suggests that oral administration of red ginseng extract can make volunteers' facial skin more elastic.

[0039] 6. Red ginseng extract has the effect of increasing the skin surface temperature. Oral administration of red ginseng extract will gradually increase the skin surface temperature.

[0040] 7. Red ginseng extract improves skin brightness. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1 Statistical graph of the red zone area ratio detection value (Mean±SEM) at different time points;

[0042] Figure 2 This is the red zone image of the subject;

[0043] Figure 3 Statistical graph of facial texture feature counts at different time points;

[0044] Figure 4 It is the subject's skin texture feature image;

[0045] Figure 5 Colorimeter L at different time points * Statistical graph of detection value (Mean ± SEM);

[0046] Figure 6 Statistical graph of stratum corneum water content detection values (Mean±SEM, CU) at different time points;

[0047] Figure 7 The values of transepidermal water loss at different time points (Mean ± SEM, g / m 2 .h) Statistical charts;

[0048] Figure 8 Statistical graph of skin elasticity-related parameter detection values (Mean±SEM) at different time points;

[0049] Figure 9 Statistical graph of skin elasticity test values (Mean±SEM) at different time points;

[0050] Figure 10 Statistical graph of skin glossiness test values (Mean±SEM) at different time points;

[0051] Figure 11 Statistical graph of skin temperature detection values (Mean±SEM) at different time points. DETAILED DESCRIPTION

[0052] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are for describing specific embodiments rather than for limiting the scope of protection of the present invention.

[0053] When the embodiments provide numerical ranges, it should be understood that, unless otherwise specified in the present invention, both endpoints of each numerical range and any numerical value between the two endpoints may be selected. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meaning as those generally understood by those skilled in the art. In addition to the specific methods, equipment, and materials used in the embodiments, according to the understanding of the prior art by those skilled in the art and the description of the present invention, any methods, equipment, and materials of the prior art similar or equivalent to the methods, equipment, and materials described in the embodiments of the present invention may also be used to implement the present invention.

[0054] Unless otherwise stated, the experimental methods, detection methods, and preparation methods disclosed in the present invention all adopt conventional techniques in this technical field.

[0055] Example

[0056] (1) Method

[0057] 1 subject

[0058] Inclusion criteria:

[0059] 1) Meet the diagnostic criteria of Qi and blood deficiency in Traditional Chinese Medicine;

[0060] 2) Females aged 25-45 years (at the start of the trial);

[0061] 3) BMI index less than 22.5; BMI = weight (kg) / height (m) 2 ;

[0062] 4) Hemoglobin (Hb) value range 85-135g / L; (You can refer to recent physical examination or test results for self-evaluation);

[0063] 5) Not allergic to commonly used cosmetics;

[0064] 6) Be able to read and understand all the contents of the informed consent form and voluntarily sign the informed consent form;

[0065] 7) During the trial period, the applicant agrees not to consume any other cosmetics, medicines, or health products that may affect the results;

[0066] 8) Not participated in other clinical studies in the past three months;

[0067] 9) During the study, other diet and skin care habits remained unchanged;

[0068] 10) No pregnancy preparation or intention during the study period;

[0069] Exclusion criteria:

[0070] 1) Pregnant or breastfeeding women, or those who are planning to get pregnant in the near future;

[0071] 2) Those with a history of skin diseases such as psoriasis, eczema, atopic dermatitis, severe acne, or other chronic systemic diseases;

[0072] 3) Those who have taken oral or topical corticosteroids or other anti-inflammatory drugs in the past month;

[0073] 4) Consuming any samples or drugs that affect skin color (such as hydroquinone preparations) such as fruit acid and salicylic acid in the past two months;

[0074] 5) The test area has consumed tretinoin preparations or undergone chemical peels, lasers, pulsed light, or other medical aesthetic treatments within the past three months;

[0075] 6) Participated in other clinical trials in the past two months;

[0076] 7) Other patients deemed unsuitable for trial participation by clinical assessment.

[0077] 2. Test samples and drinking methods

[0078] 1) Test sample

[0079] The test sample was milk powder containing red ginseng extract. The red ginseng extract added to the milk powder was obtained from red ginseng via a water extraction process, with the added amount of red ginseng extract at 300mg / 100g.

[0080] In the present invention, the active ingredients of the red ginseng extract are as follows:

[0081] The total amount of soluble polysaccharides and / or soluble oligosaccharides accounts for 0.1%-25% of the extract;

[0082] Total ginsenosides account for 0.1mg / g-300mg / g or 0.01%-0.3% of the extract;

[0083] Ginsenoside Rg1 accounts for 0.13 mg / g-60 mg / g or 0.0013%-0.06% of the extract.

[0084] 2) Drinking frequency

[0085] Drink it for a total of 56 days, twice a day, 25 grams each time, and take 50 grams per day.

[0086] 3 Test methods

[0087] 3.1 Screening

[0088] After all subjects signed the informed consent form during the first visit, they were screened according to the inclusion and exclusion criteria. Only those who met the criteria were allowed to enter the formal trial.

[0089] 3.2 Formal test

[0090] The day of the formal trial was counted as enrollment. Qualified subjects arrived at the testing center, washed their faces, and sat quietly for 30 minutes before undergoing non-invasive instrumental testing. A two-week washout period followed the test day, during which no samples were consumed. The time after the washout period was counted as day 0. A follow-up visit was conducted, during which subjects washed their faces and sat quietly for 30 minutes before undergoing non-invasive instrumental testing as a baseline value. The test samples were then taken. Two weeks after consumption was counted as day 14, four weeks after consumption was counted as day 28, and eight weeks after consumption was counted as day 56. The same tests were performed on each of these days. All tests were conducted in a laboratory controlled at a temperature of 20-22°C and a relative humidity of 40-60%.

[0091] 3.3 Instrument detection

[0092] 1) Facial Image Analyzer (VISIA, Canfield Scientific, Inc. USA)

[0093] It can capture wrinkles, textures, spots, pores, redness and other issues on the epidermis and within 2mm below the skin.

[0094] 2) Skin colorimeter (CM-26D, Konica Minolta, Japan)

[0095] The instrument collects information about the skin's reflection and scattered light to evaluate the skin's color and color difference, and converts this information into the XYZ color system and LAB color system. * It represents the brightness of the skin. The larger the value, the higher the brightness. * Reflects the red and green changes of the skin, positive values represent red, and negative values represent green. * Indicates the change of yellow and blue, positive value indicates yellow, negative value indicates blue.

[0096] 3) Stratum corneum moisture meter ( CM825,Courage&Khazaka,Germany)

[0097] The stratum corneum moisture meter measures the capacitance of dielectric materials. Because water has a dielectric constant that is significantly different from other substances, changes in capacitance are used to measure the stratum corneum moisture content. Each site is measured three times, and the average value is calculated. A higher value indicates a higher stratum corneum moisture content.

[0098] 4) Open skin transepidermal water loss meter ( TMHex,Courage&Khazaka,Germany)

[0099] The open transepidermal water loss measurement device indirectly measures skin water loss data through two pairs of sensors inside the probe. The unit is g / m 2 .h. The larger the value, the higher the transepidermal water loss rate per unit time.

[0100] 5) Skin gloss meter ( GL200, Courage&Khazaka,Germany)

[0101] The device uses white light at a certain angle to illuminate the skin, and then calculates the skin's glossiness by receiving the reflected and scattered light from the skin. The larger the value, the more glossy the skin.

[0102] 6) Skin elasticity tester ( dual MPA 580,Courage&Khazaka,Germany)

[0103] The skin elasticity test probe is based on the principles of suction and stretching. It measures the elasticity of the skin by changing the shape of the skin through negative pressure, and generates a skin suction depth-time curve in real time. MPA software analysis is used to obtain parameters reflecting the skin's firmness and elasticity, including R0 and R5. The smaller the former value, the more improved the skin's firmness, and the higher the latter value, the more elastic the skin.

[0104] 7) Skin Thermometer ST500 (Courage & Khazaka, Germany)

[0105] The probe contains an internal temperature sensor for more accurate skin surface temperature measurements. This non-contact method uses a special sensor to detect infrared light emitted by the skin surface. This method can be used to measure changes in microcirculation on the skin surface after drinking a sample. A higher value indicates a higher surface temperature.

[0106] 4 Statistical methods

[0107] 4.1 The results were statistically analyzed using SPSS Statistics 27.0. Means, standard deviations, and improvement rates were calculated for measurement data, and the Shapiro-Wilk method was used for normality testing. Data that met normal distributions were analyzed using paired t-tests; otherwise, the rank-sum test was used. Rank-sum tests were used for analysis of ranked data. The significance level was set at α = 0.05.

[0108] 4.2 The rate of change is the rate of change relative to the value before drinking. The calculation formula is as follows:

[0109] Improvement value (△ value) = T n -T0

[0110]

[0111] In the formula, T0-the skin parameter measurement value of the test area before drinking the cosmetics is the basic value

[0112] T n -Skin parameter measurements of the test area after drinking cosmetics

[0113] n-return visit time

[0114] (2) Test results

[0115] 1 subject

[0116] A total of 60 subjects were enrolled in this trial, and 50 completed the clinical study. The statistical analysis in this report is based on 50 subjects who completed 56 days of enrollment. The subjects ranged in age from 25 to 45 years, with a mean age of 36.45 ± 6.45 years.

[0117] 2Test results

[0118] 2.1 Proportion of facial red area

[0119] Compared with the baseline value on day 0, the proportion of facial red area increased by 1.88% and 2.71% on days 14 and 28, respectively, with no statistically significant difference (P>0.05). On day 56, the proportion of facial red area increased significantly by 6.50%, with a statistically significant difference (P<0.05). See Table 1 for details. Figure 1 .

[0120] Table 1 Correlation detection values of red zone area ratio at different time points (Mean±SD, %)

[0121]

[0122] Note: Compared with the basic value, the difference is statistically significant. * P<0.05.

[0123] VISIA skin red zone image Figure 2

[0124] 2.2 Facial texture feature counting

[0125] A facial image analyzer (VISIA, Canfield Scientific, Inc. USA) can capture skin wrinkles, textures, spots, pores, capillary distribution, etc. on the epidermis and within 2 mm of the subcutaneous layer. The results are shown in Table 2.

[0126] Table 2 Texture feature count correlation detection values at different time points (Mean±SD)

[0127]

[0128] Compared with 0 day, the facial texture feature counts were significantly reduced on 14 days, 28 days, and 56 days, and the differences were statistically significant ( * P < 0.1, *** P < 0.001), see Figure 3 、 Figure 4 .

[0129] 2.3L * ab value

[0130] Skin colorimeter (CM-26D, Konica Minolta, Japan)

[0131] The instrument collects information about the skin's reflection and scattered light to evaluate the skin's color and color difference, and converts this information into the XYZ color system and LAB color system. * It represents the brightness of the skin. The larger the value, the higher the brightness. * Reflects the red and green changes of the skin, positive values represent red, and negative values represent green. * Indicates the change of yellow and blue, positive value indicates yellow, negative value indicates blue. The results are shown in Table 3.

[0132] Table 3 L at different time points * Related test value (Mean±SD)

[0133]

[0134] Compared with 0day, L * The parameters increased significantly, and the differences were statistically significant ( ** P<0.01, *** P < 0.001), see Figure 5 .

[0135] a value - red and green; b value - yellow and blue; no significant changes.

[0136] 2.4 Water content of the stratum corneum

[0137] Cuticle Moisture Meter ( CM825, Courage & Khazaka, Germany).

[0138] The stratum corneum moisture content meter measures the capacitance of a dielectric. Because water has a very different dielectric constant than other substances, changes in capacitance are used to measure the stratum corneum moisture content. Each site is measured three times, and the average value is calculated. A higher value indicates a higher stratum corneum moisture content. The results are shown in Table 4.

[0139] Table 4 Correlative detection values of stratum corneum water content at different time points (Mean±SD, CU)

[0140]

[0141] Compared with 0 day, the water content of the skin stratum corneum increased on 14 day, 28 day and 56 day, and the difference was statistically significant ( ** P<0.01, *** P < 0.001), see Figure 6 .

[0142] 2.5 Transepidermal water loss

[0143] Open skin transepidermal water loss meter ( TMHex,Courage&Khazaka,Germany).

[0144] The open transepidermal water loss measurement device indirectly measures skin water loss data through two pairs of sensors inside the probe. The unit is g / m 2 The larger the value, the higher the transepidermal water loss rate per unit time. The results are shown in Table 5.

[0145] Table 5 Transepidermal water loss related test values at different time points (Mean±SD, g / m 2 .h)

[0146]

[0147] Compared with 0 day, the transepidermal water loss rate of the skin decreased at 14 days, 28 days, and 56 days, and the difference was statistically significant ( ** P<0.01, *** P < 0.001), see Figure 7 .

[0148] 2.6 Skin firming

[0149] Skin elasticity tester ( dual MPA 580,Courage&Khazaka,Germany).

[0150] The skin elasticity test probe, based on the principles of suction and stretching, measures skin elasticity by changing skin shape with negative pressure. It generates a real-time skin suction depth-time curve. MPA software analyzes this information to obtain parameters reflecting skin firmness and elasticity, including R0 and R5. A smaller R0 value indicates improved skin firmness, while a higher R5 value indicates greater skin elasticity. The results are shown in Table 6.

[0151] Table 6 Skin firmness-related test values at different time points (Mean±SD)

[0152]

[0153] Compared with 0 day, skin firmness improved on 28 days and 56 days, and the difference was statistically significant ( *** P < 0.001), see Figure 8 .

[0154] 2.7 Skin elasticity

[0155] The results are shown in Table 7.

[0156] Table 7 Skin elasticity related test values at different time points (Mean±SD)

[0157]

[0158] Compared with 0 day, skin elasticity parameter R5 increased significantly on 14 day, 28 day and 56 day, and the difference was statistically significant ( *** P < 0.001), see Figure 9 .

[0159] 2.8 Skin glossiness

[0160] The results are shown in Table 8.

[0161] Table 8 Skin glossiness related test values at different time points (Mean±SD)

[0162]

[0163] Compared with 0 day, skin glossiness increased significantly on 14 day, 28 day and 56 day, and the difference was statistically significant ( *** P < 0.001), see Figure 10 .

[0164] 2.9 Skin temperature

[0165] The results are shown in Table 9.

[0166] Table 9 Skin temperature related detection values at different time points (Mean±SD)

[0167]

[0168] Compared with 0 day, skin surface temperature parameters increased on 14 day, 28 day and 56 day, and the difference was statistically significant. Figure 11 .

[0169] (3) Conclusion

[0170] After taking the test sample orally for a total of 56 days (twice a day, 25 grams each time, 50 grams per day), the subjects' skin barrier and some physiological parameters were improved. The details are as follows:

[0171] 1. Compared to the baseline value on day 0, the proportion of facial red areas increased significantly after 56 days of drinking the test milk powder. Therefore, it can be concluded that under the conditions of this experiment, the test milk powder has improved facial Qi and blood.

[0172] 2. Compared to baseline values on day 0, facial texture feature counts decreased significantly after consuming the test milk powder for 14, 28, and 56 days. Therefore, it can be concluded that the test milk powder improved facial fine lines and texture under these experimental conditions.

[0173] 3. Compared with the baseline value on day 0, L * Significantly increased, a * value, b * Therefore, it can be concluded that under the conditions of this experiment, the tested milk powder can improve skin brightness.

[0174] 4. Compared to the baseline value on day 0, the water content of the stratum corneum increased significantly after consuming the test milk powder for 14, 28, and 56 days. Therefore, it can be concluded that under the conditions of this experiment, the test milk powder increased the moisture content of the stratum corneum.

[0175] 5. Compared to the baseline value on day 0, transepidermal water loss decreased after consuming the test milk powder for 14, 28, and 56 days. Therefore, it can be concluded that the test milk powder has the effect of repairing the skin barrier under the conditions of this study.

[0176] 6. Compared to baseline values on day 0, skin firmness parameters decreased significantly after 28 and 56 days of consumption of the test milk powder. Therefore, it can be concluded that the test milk powder has the effect of improving skin firmness under the conditions of this study.

[0177] 7. Compared to baseline values on day 0, skin elasticity significantly increased after consuming the test milk powder for 14, 28, and 56 days. Therefore, it can be concluded that the test milk powder has the effect of improving skin elasticity under the conditions of this study.

[0178] 8. Compared with the baseline value on day 0, the skin glossiness increased significantly after drinking the test milk powder for 14, 28, and 56 days. Therefore, it can be considered that under the conditions of this experiment, the test milk powder can improve skin gloss.

[0179] 9. Compared with the baseline value on day 0, the skin surface temperature increased significantly after drinking the test milk powder for 14, 28, and 56 days. Therefore, it can be considered that under the conditions of this experiment, the test milk powder can increase the skin surface temperature.

[0180] 10. During this study, no adverse reactions related to the research samples occurred.

[0181] The above description of the embodiments is intended to facilitate understanding and use of the invention by those skilled in the art. It will be apparent that those skilled in the art can readily make various modifications to these embodiments and apply the general principles described herein to other embodiments without requiring inventive effort. Therefore, the present invention is not limited to the above-described embodiments. Improvements and modifications made by those skilled in the art based on the disclosure of the present invention, without departing from the scope of the present invention, should be within the scope of protection of the present invention.

Claims

1. Use of red ginseng or red ginseng extract in the preparation of products for improving skin physiological parameters.

2. The use according to claim 1, wherein The red ginseng extract contains soluble polysaccharides, soluble oligosaccharides and ginsenosides.

3. The use according to claim 1, wherein: The product is a nutritional composition.

4. The use according to claim 3, wherein: The nutritional composition further comprises vitamins, minerals, or water extracts of plants having medicinal and edible properties.

5. The use according to claim 4, wherein: The medicinal and edible plants include one or more medicinal and edible plants such as longan, wolfberry, poria, codonopsis, cistanche, dendrobium, American ginseng, astragalus, ganoderma, sophora japonica seeds, angelica dahurica, red bean, mulberry leaf, lotus leaf, perilla, kudzu root, ginseng, honeysuckle, chrysanthemum, sophora japonica flower, rose, saffron, etc.

6. The use according to claim 1, wherein: The product is a food.

7. The use according to claim 6, wherein: The food includes beverages and dairy products.

8. The use according to claim 1, wherein: The red ginseng extract is added to the product in an amount of 10mg-18g / 100g.

9. The use according to any one of claims 1 to 8, wherein The improvement of skin physiological parameters includes improving facial Qi and blood, improving facial fine lines and texture, improving skin brightness, increasing stratum corneum moisture, repairing skin barrier, improving skin firmness, improving skin elasticity, improving skin radiance, or increasing facial skin temperature.

10. A method for improving skin physiological parameters for non-therapeutic purposes, wherein: The method comprises allowing the subject to consume red ginseng or a red ginseng extract.

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