Pituitary tumor multi-region accurate sampling device based on image navigation

Abstract

The invention discloses a pituitary tumor multi-area accurate sampling device based on image navigation, and belongs to the technical field of pituitary tumor surgical instruments, the pituitary tumor multi-area accurate sampling device comprises a sampling module assembly, a display assembly and a data processing assembly; according to the invention, an image navigation technology is combined with a sampling instrument, so that accurate sampling of different orientations or characteristic areas in the pituitary tumor is realized, the diagnosis accuracy can be improved, related research of pituitary tumor heterogeneity can be promoted, and accurate medicine is assisted.

Description

Technical Field

[0001] The present invention relates to the technical field of pituitary tumor surgical instruments, and in particular to a multi-region precise sampling device for pituitary tumors based on image navigation. Background Art

[0002] During pituitary tumor surgery (especially via the transsphenoidal approach), it is often necessary to obtain tumor tissue for pathological diagnosis, molecular testing, or to study tumor heterogeneity. However, traditional sampling methods often only obtain a single point or a small amount of tissue, making it difficult to characterize the pathological characteristics of different regions within the pituitary tumor, such as the upper and lower, left and right, center, and periphery.

[0003] However, there are deficiencies in the existing technology, including:

[0004] Low precision: Most sampling instruments can only roughly grab or clamp tumor tissue and cannot accurately locate the specific desired area.

[0005] Difficulty in real-time identification of the target area: Although preoperative images can identify certain special signs (cystic changes, solidity, cord signs, etc.), surgical instruments lack the function of interconnecting with imaging information.

[0006] Heterogeneity research is limited: If multi-region specimens cannot be obtained, it is difficult to explore tumor heterogeneity in real time during surgery, which affects scientific research and clinical diagnosis and treatment. Summary of the Invention

[0007] The present invention aims to provide a multi-region precise sampling device for pituitary tumors based on image navigation to solve the problems raised in the above background technology.

[0008] In order to achieve the above object, the present invention provides the following technical solutions:

[0009] A multi-region precise sampling device for pituitary tumors based on image navigation, characterized by comprising a sampling module component, a display component and a data processing component;

[0010] The sampling assembly consists of a partitionable sampling structure, a sensing module and an ergonomic handle. The front end of the sampling assembly is the partitionable sampling structure, the rear end is the ergonomic handle, and the sensing module is integrated into the partitionable sampling structure.

[0011] The front end of the partitionable sampling structure is a sampling head, and the rear end of the sampling head is connected to a partitionable sampling pipe, and the sampling pipe is in the form of multiple pipes;

[0012] The end of the sampling pipe away from the sampling head is connected to a receiving cavity, each of the receiving cavities is independently numbered and has a check valve or a closable valve port;

[0013] The sensing module is a sampling head with a micro optical lens integrated at the front end and a small ultrasound probe integrated at the side. The small ultrasound probe can identify cystic changes, solid areas or special structures through echo differences to determine whether the target layer to be sampled has been reached.

[0014] The sensing module can transmit data to the display component and the data processing component;

[0015] The sampling head has an adjustable sampling angle and a retractable design. The front end of the sampling head is in the form of "tweezers + knife head".

[0016] The ergonomic handle is designed in accordance with the operating characteristics of transsphenoidal neurosurgery.

[0017] The ergonomic handle is provided with an adapter interface for connecting to an endoscope, and the ergonomic handle is integrated with a rotation mechanism to align the front sampling angle with the endoscope viewing angle;

[0018] The display component includes a display and a signal component, which can receive and display data transmitted by the sensing module in the sampling component. At the same time, the display component can transmit this real-time data to the data processing component; the signal component can receive signals from the data processing component.

[0019] The data processing component includes a three-dimensional reconstruction module and a navigation module;

[0020] The three-dimensional reconstruction module imports MRI / CT / enhanced scan or special sequence into the three-dimensional reconstruction software to perform spatial reconstruction of the pituitary tumor and mark special sign areas;

[0021] In the reconstructed image, point or volume markings can be made according to the tumor morphology, adjacent structures and target sampling areas to form a navigation "region of interest" list;

[0022] The navigation module is in the operating room and provides real-time data through the sensing module;

[0023] During the operation, the spatial position of the sampling head will be projected on the navigation system interface in the form of coordinates; when the sampling head approaches the pre-marked target area, a signal will be sent to the signal element of the display component, which will send a corresponding signal to remind the operator.

[0024] Preferably, a hardness or pressure sensor is integrated at the front end of the sampling head.

[0025] Preferably, a depth or distance sensor is also integrated at the front end of the sampling head.

[0026] Preferably, the partitionable sampling structure adopts a modular design, and sampling heads of different specifications can be selected according to different tumor sizes and hardness.

[0027] Preferably, a one-way valve is provided at the point where the sampling head is docked with the sampling pipe, a one-way valve is also provided at the point where the sampling pipe is docked with each different receiving cavity, and a negative pressure suction piece is provided at the point where the receiving cavity is docked with the sampling pipe;

[0028] The sampling pipeline is also connected to a flushing component, which can flush flushing liquid into the sampling pipeline after each sampling is completed.

[0029] Preferably, the sampling device is made of lightweight materials as a whole, including medical titanium alloy, aviation aluminum or high-strength stainless steel.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] Integrated "image-guided + multi-zone sampling" design: Unlike traditional single-point or simple clamp-type sampling, this device can accurately locate and sample zones during surgery based on preoperative imaging analysis, significantly improving the targeted and comprehensive nature of sampling.

[0032] Modular, multi-cavity sampling solution: Through partitionable / switchable cavities, multiple specimens can be obtained in one cavity, adapting to different surgical needs (studying a certain sign or multiple signs coexisting).

[0033] Intelligent prompts and safety strategies: Linked with the navigation system, automatic prompts are provided upon approaching or arriving at pre-marked areas to reduce operational deviations; pressure / echo detection or optical probe-assisted identification avoids overcutting and accidental injury to normal glands or other critical structures. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 This is a schematic diagram of the overall structure of a multi-region precise sampling device for pituitary tumors based on image navigation;

[0035] Figure 2 This is a functional diagram of a multi-region precise sampling device for pituitary tumors based on image navigation;

[0036] Figure 3 This is a partially enlarged view of a multi-region precise sampling device for pituitary tumors based on image navigation.

[0037] The reference numerals in the drawings of the specification include:

[0038] 1. Sampling module assembly; 101. Partitioned sampling structure; 101a. Sampling head; 101b. Sampling pipe; 101c. Storage chamber; 101d. Negative pressure suction component; 101e. One-way valve; 101f. Flushing component; 102. Sensing module; 102a. Miniature optical lens; 102b. Small ultrasound probe; 103. Ergonomic handle; 103a. Adapter interface; 103b. Rotating mechanism; 2. Display assembly; 201. Display; 202. Signal component; 3. Data processing assembly. DETAILED DESCRIPTION

[0039] The present invention will be further described in detail below with reference to the accompanying drawings and embodiments:

[0040] like Figure 1-3 As shown, a multi-region precise sampling device for pituitary tumors based on image navigation includes a sampling module component 1, a display component 2 and a data processing component 3;

[0041] The sampling assembly consists of a partitionable sampling structure 101, a sensing module 102, and an ergonomic handle 103. The front end of the sampling assembly is the partitionable sampling structure 101, and the rear end is the ergonomic handle 103. The sensing module 102 is integrated into the partitionable sampling structure 101.

[0042] The front end of the partitionable sampling structure 101 is a sampling head 101a, and the rear end of the sampling head 101a is connected to a partitionable sampling pipe 101b. The sampling pipe 101b is a multi-pipe form (such as a coaxial double tube, triple tube, or a rotatable / switchable multi-lumen). After entering the tumor once, specimens can be obtained from different positions such as the top, bottom, left, right, center, and periphery.

[0043] Sampling pipe 101b, the end of sampling pipe 101b away from sampling head 101a is connected to the receiving chamber 101c, each of which has an independent number and is equipped with a check valve or a closable valve port to prevent cross contamination of tissue fragments and blood between different sub-chambers

[0044] The sensing module 102 is a sampling head 101a with a front-end integrated micro-optical lens 102a (visible light or near-infrared) and a side-mounted small ultrasound probe 102b (such as a high-frequency minimally invasive ultrasound module). The micro-optical lens 102a assists in identifying the tumor surface / section in a narrow space and provides a prompt to the surgeon when the light reflection or spectral characteristics match the target signs. The small ultrasound probe 102b (such as a high-frequency minimally invasive ultrasound module) uses echo differences to identify cystic changes, solid areas, or special structures, thereby helping to determine whether the target layer to be sampled has been reached.

[0045] The sensing module 102 can transmit data to the display component 2 and the data processing component 3;

[0046] The sampling head 101a has an adjustable sampling angle and a retractable design. The front end of the sampling head 101a is in the form of "tweezers + blade", which can not only clamp tumor tissue and stabilize the target area, but also gently cut or tear off the interface between the tumor and the surrounding area. The angle or length can be adjusted to a certain extent according to intraoperative needs to accommodate sampling in different directions. When layered sampling is required, the front blade can be slightly extended to cut the shallow layer; then the blade can be further extended or repositioned to obtain deep tissue.

[0047] A one-way valve 101e is provided at the point where the sampling head 101a connects to the sampling pipe 101b. A one-way valve 101e is also provided at the point where the sampling pipe 101b connects to each of the different receiving chambers 101c. A negative pressure suction element 101d is provided at the point where the receiving chamber 101c connects to the sampling pipe 101b. When the sampling head 101a completes sampling, the negative pressure suction element 101d is activated in the receiving chamber 101c corresponding to the sampling area, and the tumor sample is drawn into the corresponding receiving chamber 101c through the sampling pipe 101b. The one-way valve 101e prevents the tumor sample tissue from entering the wrong receiving chamber 101c, while also preventing backflow and contamination.

[0048] The sampling pipe 101b is also connected to a flushing part 101f, which can flush the flushing liquid into the sampling pipe 101b after each sampling is completed, so as to avoid tumor sample tissue residues in different parts and cause cross contamination;

[0049] The front end of the sampling head 101a is integrated with a hardness or pressure sensor to measure the relative distance between the front end of the device and the tumor surface in real time; combined with image navigation information, the positioning accuracy is improved.

[0050] The front end of the sampling head 101a is also integrated with a depth or distance sensor. If it detects a value significantly higher than the normal texture of the tumor or a collision value with the surrounding hard structures, it will automatically stop cutting or reduce the power output to prevent accidental damage to the skull base bone, cavernous sinus or normal glands;

[0051] At the same time, the data will be transmitted to the display component 2 in real time, and the operator can view the changes in tissue resistance during the sampling process through the display 201.

[0052] The partitionable sampling structure 101 adopts a modular design, and sampling heads 101a of different specifications can be selected according to different tumor sizes and hardness.

[0053] The ergonomic handle 103 is designed with the specific operating characteristics of transsphenoidal neurosurgery in mind. For example, grooves are designed to accommodate finger curvature and provide a comfortable grip, while a non-slip coating reduces operator fatigue. The operating buttons are strategically positioned, allowing the operator to perform key actions such as blade opening and closing, negative pressure control, and rotation angle adjustment with one hand while using the other hand to operate the endoscope or assistive instruments.

[0054] The ergonomic handle 103 is provided with an adapter interface 103a for connecting to an endoscope, which is compatible with endoscopes and laparoscopes; if it needs to be coordinated with a multi-angle endoscope, a rotating mechanism 103b can be integrated on the handle to better align the front sampling angle with the endoscope viewing angle.

[0055] The display component 2 includes a display 201 and a signal component 202, which can receive and display the data transmitted by the sensing module 102 in the sampling component. At the same time, the display component 2 can transmit this real-time data to the data processing component 3; the signal component 202 can receive the signal from the data processing component 3 and convert it into sound, light or vibration to remind the operator.

[0056] The data processing component 3 includes a 3D reconstruction module and a navigation module;

[0057] The 3D reconstruction module imports MRI / CT / enhanced scans or special sequences (such as DWI, fMRI, etc.) into the 3D reconstruction software to perform spatial reconstruction of the pituitary tumor and mark special sign areas (such as cord signs, high signals, cystic changes, etc.);

[0058] In the reconstructed image, point or volume marking can be performed based on the tumor morphology, adjacent structures (cavernous sinus, internal carotid artery, optic chiasm, etc.) and target sampling area to form a navigation "region of interest (ROI)" list;

[0059] The navigation module is located in the operating room and provides real-time data through the sensing module 102 to align the terminal position of the device with the three-dimensional reconstructed model of the patient's head in real time.

[0060] During the operation, the spatial position of the sampling head 101a will be projected on the navigation system interface in the form of coordinates; when the sampling head 101a approaches the pre-marked target area, a signal will be sent to the signal element 202 of the display component 2, which will send a corresponding signal to remind the operator.

[0061] The above is only an embodiment of the present invention, and the common knowledge such as the specific technical solutions and / or characteristics in the solution are not described in detail here. It should be pointed out that for those skilled in the art, without departing from the technical solution of the present invention, several variations and improvements can be made, which should also be regarded as the scope of protection of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the description can be used to interpret the content of the claims.

Claims

1. A multi-region precise sampling device for pituitary tumors based on image navigation, characterized by: It includes a sampling module component (1), a display component (2) and a data processing component (3); The sampling assembly is composed of a partitionable sampling structure (101), a sensing module (102), and an ergonomic handle (103). The front end of the sampling assembly is the partitionable sampling structure (101), and the rear end is the ergonomic handle (103). The sensing module (102) is integrated on the partitionable sampling structure (101). The front end of the partitionable sampling structure (101) is a sampling head (101a), and the rear end of the sampling head (101a) is connected to a partitionable sampling pipeline (101b), and the sampling pipeline (101b) is in the form of multiple pipelines; One end of the sampling pipe (101b) away from the sampling head (101a) is connected to a receiving cavity (101c), each receiving cavity is independently numbered and provided with a check valve or a closable valve port; The sensing module (102) is a sampling head (101a) having a front-end integrated micro-optical lens (102a) and a side-side integrated small-sized ultrasound probe (102b); the small-sized ultrasound probe (102b) is used to identify cystic changes, solid areas or special structures through echo differences, and to determine whether the target layer to be sampled has been reached; The sensing module (102) can transmit data to the display component (2) and the data processing component (3); The sampling head (101a) has an adjustable sampling angle and a retractable design, and the front end of the sampling head (101a) is in the form of "tweezers + knife head"; The ergonomic handle (103) is designed in combination with the operating characteristics of neurosurgery transsphenoidal surgery; The ergonomic handle (103) is provided with an adapter interface (103a) for connecting to an endoscope, and the ergonomic handle (103) is integrated with a rotation mechanism (103b) to align the front sampling angle with the endoscope viewing angle; The display component (2) includes a display (201) and a signal component (202), which can receive and display data transmitted by the sensing module (102) in the sampling component. At the same time, the display component (2) can transmit the real-time data to the data processing component (3); the signal component (202) can receive signals from the data processing component (3). The data processing component (3) includes a three-dimensional reconstruction module and a navigation module; The three-dimensional reconstruction module imports MRI / CT / enhanced scan or special sequence into the three-dimensional reconstruction software to perform spatial reconstruction of the pituitary tumor and mark special sign areas; In the reconstructed image, point or volume marking can be performed based on the tumor morphology, adjacent structures and target sampling area to form a navigation "region of interest" list; The navigation module provides real-time data in the operating room through the sensing module (102); During the operation, the spatial position of the sampling head (101a) will be projected on the navigation system interface in the form of coordinates; when the sampling head (101a) approaches the pre-marked target area, a signal will be sent to the signal element (202) of the display component (2), which will send a corresponding signal to remind the operator.

2. The image-guided multi-region precision sampling device for pituitary tumors according to claim 1, characterized in that: A hardness or pressure sensor is integrated at the front end of the sampling head (101a).

3. The image-guided multi-region precision sampling device for pituitary tumors according to claim 1, characterized in that: The front end of the sampling head (101a) is also integrated with a depth or distance sensor.

4. The image-guided multi-region precision sampling device for pituitary tumors according to claim 1, characterized in that: The partitionable sampling structure (101) adopts a modular design, and sampling heads (101a) of different specifications can be selected according to different tumor sizes and hardness.

5. The image-guided multi-region precise sampling device for pituitary tumors according to claim 1, characterized in that: A one-way valve (101e) is provided at the point where the sampling head (101a) is connected to the sampling pipe (101b), a one-way valve (101e) is also provided at the point where the sampling pipe (101b) is connected to each of the different receiving cavities (101c), and a negative pressure suction piece (101d) is provided at the point where the receiving cavity (101c) is connected to the sampling pipe (101b); The sampling pipe (101b) is also connected to a flushing component (101f), and the flushing component (101f) can flush flushing liquid into the sampling pipe (101b) after each sampling is completed.

6. The device for multi-region precise sampling of pituitary tumors based on image navigation according to any one of claims 1 to 5, characterized in that: The sampling device is made of lightweight materials as a whole, including medical titanium alloy, aviation aluminum or high-strength stainless steel.

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