Particle implantation equipment and positioning implantation method

Abstract

The invention relates to a particle implantation device and a positioning implantation method. The device comprises a frame body and an implantation tube fixedly connected with the frame body. The pushing device is mounted on the frame body; the particle bin is located between the implantation tube and the pushing device, and when the particles are placed in the particle bin, one of the particles is located on a connecting line of the implantation tube and the pushing device; a spiral-line-shaped protrusion is formed on the peripheral side of the particle in the length direction of the particle, the pushing device comprises a thread screwing-in push rod, and the thread screwing-in push rod is driven to rotate and slide, drives the particle to rotate and is pushed in the length direction of the implantation tube. By means of the arrangement, the position of the implanted particles is stable, displacement is not prone to being generated, and the adaptability of the implantation equipment and the particles is high.

Description

Technical Field

[0001] The present invention relates to the field of thermal therapy technology, and in particular to a particle implantation device and a positioning implantation method. Background Art

[0002] Currently, the main treatment options for prostate cancer include surgery, radiotherapy, and medication. Surgery carries a higher risk and is less suitable for older patients with more underlying medical conditions. Radiotherapy, however, is difficult to control due to its radioactive content and can easily cause radiation damage to surrounding tissues. Medication can cause numerous side effects, and even chemotherapy can kill normal cells.

[0003] Based on the above reasons, an alternative currently available is the use of thermotherapy particles, which utilizes an external energy field to excite particles implanted at the tumor site, causing the particles to generate heat and thereby destroy tumor cells, thereby overcoming the above-mentioned defects.

[0004] However, since the seeds need to be implanted at the tumor site in the body, the surgeon has high requirements. Not only does the implantation need to be precise, but the position must also be maintained stable during subsequent treatment. Otherwise, the parameters such as the range and intensity of the hyperthermia treatment designed by the hyperthermia treatment plan will not achieve the desired effect, and may even cause certain damage to the surrounding benign tissue cells. Regarding the implantation of hyperthermia seeds, the more conventional method is to use an implantation gun to implant the seeds into the body through a channel formed by a puncture needle. However, the conventional implantation guns currently on the market are designed for the implantation of radioactive seeds. Since radiotherapy and hyperthermia are two completely different treatment options, the structural design also takes into account the special characteristics of radiotherapy, resulting in many incompatibilities between them and hyperthermia seeds, and they cannot be directly converted. Summary of the Invention

[0005] In order to solve the above-mentioned defects, the present invention proposes a particle implantation device and a positioning implantation method.

[0006] The technical solution adopted by the present invention is that the particle implantation device for magnetic hyperthermia particles includes a frame, and the frame is further provided with: an implant tube, which is fixedly connected to the frame and guides the particles to pass through; a pushing device, mounted on the frame, for applying a force to the particles to enable them to pass through the implant tube; a particle chamber located between the implant tube and the pushing device, wherein when the particles are placed in the particle chamber, one of the particles is located on the line connecting the implant tube and the pushing device; The particle has a helical protrusion formed along its length. The pushing device includes a threaded push rod. The threaded push rod is driven to rotate and slide, driving the particle to rotate and propel it along the length of the implant tube. The particle's rotation direction is consistent with the helical direction of the helical protrusion.

[0007] Preferably, a buffer layer is provided at one end of the threaded push rod that contacts the particle, and the buffer layer is made of a biocompatible flexible material, and at least one micro-protrusion is provided on the side of the buffer layer that contacts the particle. When the buffer layer contacts the particle, the micro-protrusion can contact the side of the spiral protrusion on the particle.

[0008] Preferably, the pushing device includes a micro motor, a transmission turbine and an electric control button. The electric control button is arranged on the frame and opens and closes the micro motor. The transmission turbine is connected to the micro motor and drives the threaded push rod to advance.

[0009] Preferably, a guide rod is fixedly provided on the frame body, and a cavity with one end open is formed along the length direction of the axis of the threaded push rod. The guide rod is inserted into the cavity and rotated to cooperate with the threaded push rod.

[0010] Preferably, the particle bin includes a fixing seat and a bin body, the fixing seat is fixed on the frame, the bin body is detachably connected to the fixing seat, and the particles are stored in the bin body.

[0011] Preferably, the implant tube comprises a tube body and a head that are integrally connected, the cross section of the head gradually increases along the axial direction, and the opening of the head is adapted to engage with the fixing seat.

[0012] Preferably, the inner walls of the tube body and the head are coated with polytetrafluoroethylene coating.

[0013] Preferably, the particle includes a front end and a tail end along its length, the spiral protrusion is located between the front end and the tail end, a plurality of barbs made of polycaprolactone are fixed to the tail end of the particle, and the free ends of the plurality of barbs are pre-tightened and fixed to the embolic sheet, and the embolic sheet is made of a water-soluble material with good biocompatibility; The end of the threaded push rod is concave to form an avoidance cavity. When the threaded push rod abuts against the tail end of the particle, the barbs of the particle are all received in the avoidance cavity.

[0014] The present invention also proposes a positioning implantation method, using a particle implantation device as described in any of the above items, the method comprising: locating the implantation position of the magnetocaloric particles, determining the implantation path, and implanting the particles into a predetermined implantation position according to the implantation path.

[0015] Preferably, after implantation at a predetermined implantation position, the method further includes: fixing the position of the particles; the fixing method includes at least one of thermal coagulation self-fixation of the magnetocaloric particles, fixation between the helical protrusions formed on the outer surface of the particles and the cells, or fixation formed after the barbs at the tail end of the particles are released.

[0016] Compared with the prior art, the present invention has the following beneficial effects: 1. The surface of the magnetocaloric particles is formed with spiral protrusions. This configuration makes it easier for the particles to enter the tumor cells and form a more stable wrapping and fixation with the surrounding cells, thus reducing the displacement of the particles after surgery. 2. Because there is a certain amount of resistance when the particles are pushed into the implant tube, and the setting of the helical protrusion will increase the resistance, a threaded screw-in push rod is designed specifically. It adopts a spiral propulsion method, which can drive the particles to rotate while pushing. It utilizes the spiral characteristics of the helical protrusion to overcome the resistance during the screw-in process, making it more stable. 3. The setting of the buffer layer can greatly absorb the stress during impact and prevent the thread from damaging the tail end of the particle when the push rod is screwed into the thread, especially when there is a barb at the tail end; 4. The barbs on the particle's tail allow it to be fixed to surrounding cells after entering the body temperature environment of tumor cells, preventing displacement. The barbs made of polycaprolactone can be softened once heated and hyperthermia is applied, without affecting the radiation of the thermal field, and can also be removed smoothly. 5. In order to adapt to the barb structure, the end of the threaded push rod is concave to form an avoidance cavity. When the threaded push rod abuts against the tail end of the particle, the barbs of the particle are all received in the avoidance cavity without affecting the propulsion and rotation. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The present invention is described in detail below with reference to the embodiments and accompanying drawings, in which: Figure 1 is an isometric view of one embodiment of the present invention; Figure 2 yes Figure 1 A schematic diagram of the middle fixing seat without one side structure, mainly showing the relationship between the internal structure of the fixing seat and the adjacent structures; Figure 3 yes Figure 2 Enlarged view of point A in the middle; Figure 4 It is a schematic structural diagram of particles and a threaded push rod in one embodiment of the present invention.

[0018] in Figure 2 and Figure 3The peripheral side of the particles shown in the figure is smooth, but may also have helical protrusions or be engraved with thread grooves.

[0019] 10. Frame; 11. Particle chamber; 12. Fixing seat; 13. Chamber body; 14. Guide rod; 20. Implant tube; 21. Tube body; 22. Head; 30. Micro motor; 31. Transmission turbine; 32. Electric control button; 33. Threaded push rod; 34. Avoidance chamber; 40. Particle; 41. Helical protrusion; 42. Barb; 50. Insertion spring; 51. Compression spring. DETAILED DESCRIPTION

[0020] To make the objectives, technical solutions, and advantages of the present invention more apparent, embodiments of the present invention will be described in further detail below with reference to the accompanying drawings. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar components or components having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended only to explain the present invention and are not to be construed as limiting the present invention.

[0021] The present invention discloses a particle implantation device for use in the field of magnetic hyperthermia, particularly for the implantation of magnetothermal particles. To improve the positional stability of the particles after implantation into tumor cells, the present invention employs a structural design that forms helical protrusions along the circumference of the particles along their length. Alternatively, helical grooves can be formed in different processes, with a pitch of 0.5 mm. This facilitates encapsulation and adsorption between the protrusions or grooves and the cells after implantation, thereby improving the stability of the particles within the body.

[0022] Currently, there are many implantation guns for radiotherapy seeds on the market, but their designs are often incompatible with the seeds of the present invention. This is because radioactive seeds, such as I-125, have a smooth surface (Ra < 0.5 μm), while the barbs or spiral grooves of thermotherapy seeds mechanically interlock with the metal channel of the implantation gun, increasing the push resistance by 3-5 times, causing the seeds to rotate and deflect within the gun barrel, resulting in positioning errors greater than 0.5 mm. Further reducing the diameter of the gun tube to reduce this error will further increase the push resistance and may even damage the end of the seed.

[0023] Furthermore, the push rod of the radiation implantation gun generates considerable heat as it repeatedly propels the seeds. While this heat does not affect subsequent radiotherapy, the magnetic hyperthermia seeds are coated. Furthermore, in one embodiment of the present invention, the seeds are also equipped with barbs at their tails, which are restrained by an embolic disc before entry. If the gun barrel temperature rises sufficiently, the barbs will soften. Furthermore, the push rod will continue to contact and rub against the next seed in the seed chamber, which is about to enter the barrel, damaging the coating on the seed surface. These and other issues contribute to the unsuitability of existing radiation implantation guns for magnetic hyperthermia seed implantation.

[0024] In one embodiment, Figure 1-2 As shown, the particle implantation device includes a frame 10, and the frame 10 is further provided with: an implant tube 20 , which is fixedly connected to the frame 10 and guides the particles 40 to pass through; a pushing device mounted on the frame 10 to apply force to the particles 40 to enable them to pass through the implant tube 20; a particle chamber 11, which is located between the implant tube 20 and the pushing device. When the particles 40 are placed in the particle chamber 11, one of the particles 40 is located on the line connecting the implant tube 20 and the pushing device; like Figure 4 As shown, the particle 40 is formed with a spiral protrusion 41 along its longitudinal side, and the pushing device includes a threaded push rod 33. After being driven, the threaded push rod 33 rotates and slides, driving the particle 40 to rotate and advance along the longitudinal direction of the implant tube 20.

[0025] like Figure 1-2 As shown, the particle bin 11 includes a fixing seat 12 and a bin body 13. The fixing seat 12 is fixed to the frame 10, and the bin body 13 is detachably connected to the fixing seat 12. The particles 40 are stored in the bin body 13. The implant tube 20 is fixed to the frame 10 and includes an integrally connected tube body 21 and a head 22. The cross-section of the head 22 gradually increases along the axial direction, and the opening is adapted to engage with the fixing seat 12. That is, the particles 40 fall from the bin body 13 into the fixing seat 12 in sequence and are screwed into the push rod 33 and pushed into the implant tube 20 from the same direction.

[0026] The fixing seat 12 can be integrally formed with the frame 10 and is located between the implant tube 20 and the pushing device. The fixing seat 12 includes at least three openings, a pair of which are used for the threaded insertion and withdrawal of the push rod 33, thereby completing the propulsion of the particle 40, and the other opening is upward, for the particle 40 to fall from the chamber 13 into the fixing seat 12. The chamber 13 can store multiple particles 40, and the detachable design between it and the fixing seat 12 can be a conventional snap-on or plug-in design, or other common detachable methods; similarly, the design of the chamber 13 can also draw on the particle 40 storage structure of a magazine or a radiation implant gun, and can be a simple shell with an open end for placing multiple particles 40, or a spring can be provided inside the shell to apply an elastic force to push the particles 40 outward.

[0027] The enlarged design of the head 22 of the implant tube 20 facilitates the entry of the particle 40 into the tube body 21, preventing the particle 40 from mechanically interfering with the tube opening of the implant tube 20 if misaligned. The tube body 21 of the implant tube 20 extends into the body, and both the particle 40 and the threaded push rod 33 enter the tube body 21 after passing through the head 22.

[0028] In one embodiment, in order to reduce friction and heat during sliding, the inner walls of the tube body 21 and the head 22 of the implant tube 20 are coated with polytetrafluoroethylene.

[0029] In one embodiment, in order to prevent the threaded push rod 33 from exerting too much impact on the particles 40, a buffer layer is provided at one end of the threaded push rod 33 that contacts the particles 40. The buffer layer is made of a biocompatible flexible material. Specifically, the buffer layer is a 100 μm thick silicone pad (not shown in the figure).

[0030] Furthermore, at least one micro-protrusion is provided on the side where the buffer layer contacts the particle 40. When the buffer layer contacts the particle 40, the micro-protrusion can contact the side of the spiral protrusion 41 on the particle 40. Preferably, the micro-protrusion can be provided as a pair or multiple, so that when the threaded push rod 33 contacts the particle 40, the threaded push rod 33 is driven to rotate, the micro-protrusion contacts the side of the spiral protrusion 41 and drives the particle 40 to rotate synchronously. Of course, the rotation direction of the threaded push rod 33 and the particle 40 is consistent with the spiral direction of the spiral protrusion 41. In addition, even if the micro-protrusion fails to contact the side of the spiral protrusion 41 and drive the particle 40 to rotate synchronously, it can still achieve the effect of driving the particle 40 to rotate by relying on friction.

[0031] In one embodiment, the pushing device includes a micromotor 30, a transmission turbine 31, and an electric control button 32. The electric control button 32 is disposed on the frame 10 and activates and deactivates the micromotor 30. The transmission turbine 31 is power-connected to the micromotor 30 and drives the threaded advancement push rod 33. Two electric control buttons 32 may also be provided, one to control the forward and reverse rotation of the micromotor 30, thereby correspondingly advancing or retracting the threaded advancement push rod 33.

[0032] Furthermore, a guide rod 14 is fixedly provided on the frame body 10 , and a cavity with one end open is formed along its length direction at the axis of the threaded push rod 33 , and the guide rod 14 is inserted into the cavity and rotated to cooperate with the threaded push rod 33 .

[0033] The guide rod 14 serves as a limit constraint and guide for the threaded screw-in push rod 33, so that the threaded screw-in push rod 33 can maintain a coordinated relationship with the turbine. After the turbine is driven by the power of the micro motor 30, the threaded screw-in push rod 33 is rotated and slid. Moreover, the length of the guide rod 14 needs to be greater than the stroke of the threaded screw-in push rod 33, which can further improve the stability and accuracy of the linear reciprocating motion of the threaded screw-in push rod 33.

[0034] In the aforementioned embodiment, the chamber body 13 and the fixing seat 12 are described as being detachable. In this embodiment, the chamber body 13 is mounted above or to the side of the fixing seat 12. If the chamber body 13 is mounted above, the particles 40 can fall into the fixing seat 12 one by one under their own weight. If the chamber body 13 is mounted to the side, the particles 40 need to be pushed into the fixing seat 12 one by one by the action of a spring. However, regardless of the mounting position, when the first particle 40 is being pushed, the next particle 40 in the chamber body 13, which is about to enter the fixing seat 12, will inevitably abut against the threaded push rod 33. Moreover, as the threaded push rod 33 moves forward or backward, significant friction will occur between the threads on the threaded push rod 33 and the next particle 40.

[0035] In order to solve this problem, the present embodiment further installs a plug-in spring piece 50 on the frame 10. Figure 1-3 As shown, the plug-in spring 50 is slidably constrained on the frame 10, and a compression spring 51 is provided between one end of the plug-in spring 50 and the frame 10. The other end of the plug-in spring 50 can be inserted into the gap between the magazine body 13 and the fixing seat 12 under the action of the compression spring 51.

[0036] Specifically, the insert spring 50 is L-shaped overall, with its horizontal section arranged parallel to the threaded push rod 33 and its vertical section used to mount the compression spring 51. The end of the horizontal section is configured as an inclined or curved surface. When inserted into the gap between the chamber 13 and the fixed seat 12, it can contact the particles 40 in the chamber 13 and prevent the particles 40 from moving further into the fixed seat 12. Moreover, during the entire process of the threaded push rod 33 pushing the first particle 40, it also isolates the next particle 40 from the threaded push rod 33, thereby preventing friction between the next particle 40 and the threaded push rod 33.

[0037] In one embodiment, the plug-in spring piece 50 is T-shaped as a whole, with its horizontal section arranged parallel to the threaded push rod 33, the upper half of the vertical section is used to install the compression spring 51, and the lower half abuts against the end of the threaded push rod 33.

[0038] Preferably, the cross section of the particle 40 is circular, and the distance at which the horizontal section of the plug-in spring 50 is inserted into the gap between the chamber body 13 and the fixing seat 12 is one-third or one-quarter of the diameter of the cross section of the particle 40, that is, the particle can be limited in insertion without being inserted too deep.

[0039] In this embodiment, the vertical section of the plug-in spring 50 is located between the end of the threaded push rod 33 and the end of the frame 10. When the threaded push rod 33 is reset and the end thereof that contacts the particles 40 exits the particle chamber 11, the other end of the threaded push rod 33 contacts the vertical section of the plug-in spring 50 and drives the plug-in spring 50 to slide along the frame 10 until it exits the fixed seat 12 of the particle chamber 11. At this time, the particles 40 in the chamber 13 lose the limiting constraint of the plug-in spring 50 and can smoothly enter the fixed seat 12. After the threaded push rod 33 is restarted, the threaded push rod 33 pushes the particles 40 in the fixed seat 12 into the implant tube 20. At the same time, the threaded push rod 33 no longer contacts the vertical section of the plug-in spring 50. Therefore, the plug-in spring 50 as a whole will slide again under the action of the compression spring 51 until it is inserted into the gap between the chamber 13 and the fixed seat 12.

[0040] In one embodiment, in order to improve the stability of the magnetic hyperthermia particles 40 after implantation and reduce displacement, the particles 40 are further improved. Specifically, Figure 4 As shown, the particle 40 includes a front end and a tail end along its length, the spiral protrusion 41 is located between the front end and the tail end, and a plurality of barbs 42 made of polycaprolactone are fixed to the tail end of the particle 40. The free ends of the plurality of barbs 42 are pre-tightened and fixed to an embolic sheet (not shown in the figure), and the embolic sheet is made of a water-soluble material with good biocompatibility; The end of the threaded push rod 33 is concave to form an escape cavity 34 . When the threaded push rod 33 abuts against the tail end of the particle 40 , the barbs 42 of the particle 40 are all received in the escape cavity 34 .

[0041] In this embodiment, the barbs 42 have a height of 0.1-0.3 mm and are present in at least two, and may be three or more. The barbs 42 are preferably strip-shaped or columnar, and are radially arranged at the tail end of the particle 40. That is, the ends of adjacent barbs 42 that are closest to each other are fixed to the tail end of the particle 40, while the ends farther away are free and tilted outward.

[0042] Since the barbs 42 are made of polycaprolactone, which has a high hardness under body temperature, the multiple barbs 42 will open and prevent cells from abutting against the surrounding area, further stabilizing the installation position of the particle 40. When heat therapy is performed, when the temperature reaches 40-50°C, the barbs 42 will soften again, which will not affect the therapeutic effect of the heat field. Moreover, during general treatment at this time, the human body will not move. When the particle 40 is subsequently removed, it can be heated first and then removed, and the barbs 42 will not affect it.

[0043] In this embodiment, an embolic sheet is used to constrain the barbs 42 during particle implantation. This is to prevent the barbs 42 from expanding and rubbing against the body 21 of the implant tube 20 during implantation. Once inside the body, the embolic sheet, made of a water-soluble material with good biocompatibility, dissolves, releasing the barbs 42. Specifically, the embolic sheet is made of hypromellose and dissolves in approximately 30 seconds. The barbs 42 can be embolized by encapsulating them or by forming a cavity in the embolic sheet, confining the barbs within the cavity.

[0044] The present invention also discloses a method for the localized implantation of magnetic hyperthermia particles, utilizing the particle implantation apparatus described above. The method comprises: locating the implantation position of the magnetic hyperthermia particles, determining an implantation path, implanting the particles into the predetermined implantation position according to the implantation path; and fixing the position of the particles. The fixing method includes at least one of self-fixation by thermal coagulation of the magnetic hyperthermia particles, fixation between the helical protrusions formed on the outer surface of the particles and the cells, or fixation formed after the release of the barbs at the tail end of the particles.

[0045] In one embodiment, the three aforementioned methods are simultaneously used for fixing the particles.

[0046] In this specification, the use of terms such as "Embodiment 1," "this embodiment," and "in one embodiment" indicates that the specific features, structures, materials, or characteristics described in conjunction with that embodiment or example are included in the invention or at least one embodiment or example of the invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example; furthermore, the specific features, structures, materials, or characteristics described may be appropriately combined in any one or more embodiments or examples.

[0047] In the description of this specification, the terms "connect," "install," "fix," "dispose," and "have" are to be understood in a broad sense. For example, "connect" can mean a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be internal communication between two components. Those skilled in the art will understand the specific meanings of the above terms in this application based on specific circumstances.

[0048] In the description of this specification, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises", "comprising" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or apparatus comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article or apparatus. In the absence of further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of additional identical elements in the process, method, article or apparatus comprising the element.

[0049] The above description of the embodiments is to facilitate ordinary technicians in this technical field to understand and apply the technology of this case. People familiar with the technology in this field can obviously make various modifications to these examples easily and apply the general principles described here to other embodiments without having to go through creative work. Therefore, this case is not limited to the above embodiments. Modifications to the following situations should all be within the scope of protection of this case: ① A new technical solution implemented based on the technical solution of the present invention and combined with existing common knowledge, the technical effect produced by the new technical solution does not exceed the technical effect of the present invention; ② The equivalent replacement of some features of the technical solution of the present invention with the known technology, the technical effect produced is the same as the technical effect of the present invention; ③ The technical solution of the present invention is expandable, and the substantive content of the expanded technical solution does not exceed the technical solution of the present invention; ④ The equivalent transformation made by the content of the description and drawings of the present invention is directly or indirectly applied to other related technical fields.

Claims

1. A particle implantation device for magnetic hyperthermia particles, comprising a frame, characterized in that: The frame is also provided with: an implant tube, which is fixedly connected to the frame and guides the particles to pass through; a pushing device, mounted on the frame, for applying a force to the particles to enable them to pass through the implant tube; a particle chamber located between the implant tube and the pushing device, wherein when the particles are placed in the particle chamber, one of the particles is located on the line connecting the implant tube and the pushing device; The particles are formed with spiral protrusions along their lengthwise circumferences. The pushing device comprises a threaded push rod. The threaded push rod is driven to rotate and slide, driving the particles to rotate and push along the lengthwise direction of the implant tube.

2. The particle implantation device according to claim 1, characterized in that A buffer layer is provided at one end of the threaded push rod that contacts the particle. The buffer layer is made of a biocompatible flexible material, and at least one micro-protrusion is provided on the side of the buffer layer that contacts the particle. When the buffer layer contacts the particle, the micro-protrusion can contact the side of the spiral protrusion on the particle.

3. The particle implantation device according to claim 1, characterized in that The pushing device includes a micro motor, a transmission turbine and an electric control button. The electric control button is arranged on the frame and turns the micro motor on and off. The transmission turbine is connected to the micro motor and drives the threaded push rod to rotate forward.

4. The particle implantation device according to claim 3, characterized in that The frame is also fixed with a guide rod, and a cavity with one end open is formed along the length direction of the axis of the threaded push rod. The guide rod is inserted into the cavity and rotates with the threaded push rod.

5. The particle implantation device according to claim 2, characterized in that The particle bin includes a fixing seat and a bin body, wherein the fixing seat is fixed on the frame, the bin body is detachably connected to the fixing seat, and the particles are stored in the bin body.

6. The particle implantation device according to claim 5, characterized in that The implant tube comprises a tube body and a head connected in one piece. The cross section of the head gradually increases along the axial direction, and the opening of the head is adapted to be connected with the fixing seat.

7. The particle implantation device according to claim 6, characterized in that The inner walls of the tube body and the head are both coated with polytetrafluoroethylene coatings.

8. The particle implantation device according to claim 1, characterized in that The particle includes a front end and a tail end along its length, the spiral protrusion is located between the front end and the tail end, and a plurality of barbs made of polycaprolactone are fixed to the tail end of the particle, and the free ends of the plurality of barbs are pre-tightened and fixed to the embolic sheet, and the embolic sheet is made of a water-soluble material with good biocompatibility; The end of the threaded push rod is concave to form an avoidance cavity. When the threaded push rod abuts against the tail end of the particle, the barbs of the particle are all received in the avoidance cavity.

9. A method for positioning implantation, using the particle implantation apparatus according to any one of claims 1 to 8, characterized in that: The method comprises: locating an implantation position of magnetocaloric particles, determining an implantation path, and implanting the particles into a predetermined implantation position according to the implantation path.

10. The method according to claim 9, characterized in that After implanting the particles into the predetermined implantation positions, the method further includes fixing the positions of the particles.

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