Supramolecular repair essence and preparation method thereof

Abstract

The invention provides supramolecular repair essence and a preparation method thereof, and belongs to the technical field of cosmetics. The supramolecular repairing essence is prepared from the following components in parts by weight: 0.2 to 0.5 part of a supramolecular composition, 5 to 10 parts of a plant extract, 10 to 20 parts of a humectant and 40 to 80 parts of water, the preparation method of the supramolecular composition comprises the following steps: (1) dissolving hydroxypropyl alpha-cyclodextrin in water, then adding calendaring element and ligustilide, and stirring at 60 DEG C for 3 hours to obtain a mixed solution; and (2) carrying out spray drying on the mixed solution to obtain the supramolecular composition, according to the invention, the supramolecular composition and the plant extract are mixed, and the specific variety of the plant extract and the mass ratio of the components are controlled, so that the obtained essence not only has a better repairing effect, but also has obviously enhanced moisturizing and antibacterial effects.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a supramolecular repair essence and a preparation method thereof. Background Art

[0002] As the largest organ in the human body, the skin plays a vital role in protecting internal organs, promoting excretion, and regulating body temperature. Affected by various external factors, the skin can develop aging symptoms such as hyperpigmentation, dryness, and wrinkles, impacting people's mental health. Using cosmetics can, to a certain extent, protect the skin and slow down aging. The stratum corneum, the superficial layer of the skin, is lipophilic, preventing most active ingredients from entering the dermis. Therefore, the polarity and molecular weight of the active ingredient, its apparent solubility in oil and water, and the formulation type and composition significantly influence its permeability. Therefore, regulating the skin permeation of active ingredients to improve their bioavailability is a pressing issue.

[0003] Supramolecular chemistry refers to the formation of molecular aggregates of chemical substances through non-covalent interactions such as electrostatics, hydrogen bonds, van der Waals forces, hydrophobic interactions, and dynamic covalent bonds. Due to the superior physicochemical properties and biological activity of supramolecular structures, supramolecular technology has been widely applied in biomedicine, tissue engineering, and industrial products over the past 20 years.

[0004] Chinese patent CN114306113A discloses a supramolecular carnosine and a composition containing supramolecular carnosine, as well as a preparation method and application thereof. The supramolecular carnosine is formed by hydrogen bonding of acetylcarnosine with one or both of decarboxylated carnosine hydrochloride and carnosine; wherein the molar ratio of decarboxylated carnosine hydrochloride, acetylcarnosine, and carnosine is (0-10):(1-10):(0-14). The supramolecular carnosine synthesized by utilizing the supramolecular interaction between the structures of carnosine derivatives has an anti-glycation function; when combined with a protective agent and excipients, and then compounded based on the stability, target, and synergistic effects of the raw materials, the bioavailability of the raw materials can be improved in multiple dimensions, and the anti-glycation effect can be more stably exerted; when the composition containing supramolecular carnosine is applied to dosage-form cosmetics, it has the advantages of good stability, safety, mildness, and a specific, long-lasting, and effective anti-glycation effect.

[0005] Chinese patent CN118436556A discloses a method for preparing resveratrol supramolecules, comprising the following steps: S11. Dissolving a cyclodextrin derivative in a solvent, then adding resveratrol, and stirring at 40-80°C for 1-3 hours to obtain a mixed solution; S12. Spray-drying the mixed solution to obtain the resveratrol supramolecules. Studies have shown that the resveratrol supramolecules prepared by this method exhibit superior antioxidant activity compared to an equal amount of resveratrol and, in addition, exhibit reduced skin irritation compared to resveratrol. Further studies have shown that a composition obtained by mixing the resveratrol supramolecules with a Polygonum cuspidatum root extract exhibits significant, even excellent, anti-Propionibacterium acnes activity. Therefore, the resveratrol supramolecules and / or compositions described in this invention have significant application value as active ingredients in the preparation of cosmetics or pharmaceuticals.

[0006] However, there are very few reports on repair essences containing supramolecular components. Therefore, the present invention aims to provide a supramolecular repair essence with moisturizing, repairing and antibacterial effects and a preparation method thereof. Summary of the Invention

[0007] Based on the deficiencies of the prior art, the present invention aims to provide a supramolecular repair essence and a preparation method thereof. By mixing a supramolecular composition with a plant extract and controlling the specific types of the plant extracts and the mass ratios between the components, the obtained essence not only has a better repair effect, but also significantly enhances the moisturizing and antibacterial effects.

[0008] In order to achieve the above object, the present invention adopts the following technical solutions: A supramolecular repair essence comprises the following components in parts by weight: 0.2-0.5 parts of a supramolecular composition, 5-10 parts of a plant extract, 10-20 parts of a moisturizer and 40-80 parts of water.

[0009] Preferably, the supramolecular repair essence comprises the following components by weight: 0.3-0.4 parts of the supramolecular composition, 6-9 parts of the plant extract, 12-18 parts of the moisturizer and 50-70 parts of water.

[0010] More preferably, the supramolecular repair essence comprises the following components in parts by weight: 0.35-0.4 parts of the supramolecular composition, 7-8 parts of the plant extract, 15-18 parts of the moisturizer and 60-70 parts of water.

[0011] in, The preparation method of the supramolecular composition is as follows: (1) Dissolve hydroxypropyl α-cyclodextrin in water, then add calendulin and ligustilide, and stir at 60°C for 3 h to obtain a mixed solution; (2) The mixed solution is spray-dried to obtain the supramolecular composition.

[0012] The mass ratio of calendulin and ligustilide is 3-5:1, preferably 4:1.

[0013] The mass ratio of hydroxypropyl α-cyclodextrin, calendulin, ligustilide and water is 80-90:9-15:3:200-300; Preferably, the mass ratio of hydroxypropyl α-cyclodextrin, calendulin, ligustilide and water is 85:12:3:250.

[0014] The present invention provides a supramolecular composition containing calendulin and ligustilide. Experimental results show that the supramolecular composition prepared by the present invention is better absorbed by the skin and has enhanced anti-inflammatory, antibacterial, itching, skin softening, and acne-preventing effects. Compared with the use of calendulin and / or ligustilide alone, it is less irritating.

[0015] The plant extract is a mixture of chrysanthemum extract, chuanxiong extract and peony extract.

[0016] The mass ratio of the chrysanthemum extract, Chuanxiong extract and peony extract is 3-5:1:1-2; Preferably, the mass ratio of the chrysanthemum extract, Chuanxiong extract and peony extract is 4:1:2.

[0017] The preparation method of the chrysanthemum extract is: Chrysanthemum is extracted with ethanol to obtain an extract; the extract is concentrated, dried and crushed to obtain the chrysanthemum extract.

[0018] The mass volume ratio of the chrysanthemum and ethanol is 1:10-15, preferably 1:10.

[0019] The volume fraction of the ethanol is 70-80%, preferably 80%.

[0020] The preparation method of the Chuanxiong extract is as follows: The Chuanxiong rhizome is cleaned and sliced, and extracted with water to obtain an extract; the extract is concentrated and dried to obtain the Chuanxiong rhizome extract.

[0021] The mass volume ratio of Chuanxiong and water is 1:5-10, preferably 1:8.

[0022] The preparation method of the peony extract is: The peony root is cleaned and extracted with ethanol to obtain an extract; the extract is concentrated, dried and crushed to obtain the peony extract.

[0023] The mass volume ratio of the peony root to the ethanol is 1:10-15, preferably 1:12.

[0024] The volume fraction of the ethanol is 80-90%, preferably 85%.

[0025] The moisturizing agent is selected from hyaluronic acid and / or seaweed polysaccharide.

[0026] Preferably, the moisturizing agent is a mixture of hyaluronic acid and seaweed polysaccharide.

[0027] More preferably, the mass ratio of the hyaluronic acid to the seaweed polysaccharide is 5-10:1; preferably 8:1.

[0028] As a preferred embodiment, the supramolecular repair essence comprises the following components by weight: 0.4 parts of supramolecular composition, 4 parts of chrysanthemum extract, 1 part of Chuanxiong extract, 2 parts of peony extract, 16 parts of hyaluronic acid, 2 parts of seaweed polysaccharide and 60 parts of water.

[0029] The preparation method of the supramolecular composition is as follows: (1) Dissolve hydroxypropyl α-cyclodextrin in water, then add calendulin and ligustilide, and stir at 60°C for 3 h to obtain a mixed solution; (2) The mixed solution is spray-dried to obtain the supramolecular composition.

[0030] The mass ratio of the hydroxypropyl α-cyclodextrin, calendula, ligustilide and water is 85:12:3:250.

[0031] The present invention also provides a method for preparing the supramolecular repair essence, comprising the following steps: S1, mixing a moisturizing agent and water to obtain a mixture, S2. Add the supramolecular composition and the plant extract to the mixture obtained in step S1 and mix them evenly to obtain the supramolecular repair essence.

[0032] Compared with the prior art, the present invention has the following beneficial effects: 1) The present invention provides a supramolecular composition containing calendulin and ligustilide. Experimental results indicate that the supramolecular composition prepared by the present invention is better absorbed by the skin and exhibits enhanced anti-inflammatory, antibacterial, antipruritic, skin-softening, and acne-preventing effects. It is also less irritating than the use of calendulin and / or ligustilide alone.

[0033] 2) The present invention uses calendulain and ligustilide as active ingredients to prepare a supramolecular composition. Calendulain is an active ingredient in calendula, which has strong anti-inflammatory ability and can be used to treat various skin inflammations. It can calm and soothe the skin, reduce redness and inflammatory reactions caused by sensitivity or external stimuli, and help the growth of new cells, thereby accelerating wound repair. It also has good antibacterial properties. Ligustilide, as an active ingredient in angelica, has significant anti-inflammatory activity and can be used to relieve skin inflammation, such as redness, itching and other symptoms. It has antioxidant effects, can help resist free radical damage to the skin, slow down skin aging, and can improve microcirculation and reduce skin problems caused by microcirculatory disorders. However, calendulain and ligustilide, as natural extracts, have the problem of instability. The present invention uses a special process to prepare calendulain and ligustilide into supramolecular compounds, which significantly improves their poor stability and reduces the irritation of both.

[0034] 3) The present invention adopts a combination of supramolecular composition + plant extracts, using a mixture of chrysanthemum extract, Chuanxiong extract and peony extract as the plant extract. By rationally controlling the mass ratio of the three, the anti-inflammatory and repair effects of the composition are significantly improved.

[0035] 4) The present invention uses a mixture of hyaluronic acid and seaweed polysaccharides as a moisturizer. By controlling the mass ratio of the two, the moisturizing effect of the composition is significantly improved. The supramolecular composition enables the active ingredients to better penetrate the skin, and the plant extracts can effectively alleviate skin problems. Hyaluronic acid and seaweed polysaccharides can not only moisturize but also form an effective barrier on the skin surface to reduce water evaporation. As a result, the resulting essence not only has a good repair effect, but also has significantly enhanced moisturizing and antibacterial effects. DETAILED DESCRIPTION

[0036] The following will be combined with the tables in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0037] Hereinafter, examples of the present invention and comparative examples will be shown to explain the composition of the present invention in more detail, but the present invention is not limited thereto.

[0038] The present invention does not limit the sources of the raw materials used. Unless otherwise specified, the raw materials used in the present invention are all common commercially available products in the present technical field. Chrysanthemum, Chuanxiong and Peony were all purchased from pharmacies, calendulain was purchased from Xi'an Jincuifang Plant Technology Development Co., Ltd., and ligustilide was purchased from Shanghai Maibo Pharmaceutical Technology Co., Ltd.

[0039] Basic Example 1: The preparation method of chrysanthemum extract is: Chrysanthemum was extracted with 80% ethanol under reflux at 80°C for 5 hours at a material-liquid ratio of 1g:10ml to obtain an extract; the extract was concentrated, dried and crushed to obtain the chrysanthemum extract.

[0040] Basic Example 2: The preparation method of Chuanxiong extract is: Take Chuanxiong, clean it, slice it, and extract it with water for 3 hours with a solid-liquid ratio of 1g:8ml to obtain an extract; the extract is concentrated and dried to obtain the Chuanxiong extract.

[0041] Basic Example 3: The preparation method of peony extract is: After cleaning the peony root, extract it with 85% ethanol under reflux at 80°C for 5 hours with a solid-liquid ratio of 1g:12ml to obtain an extract; the extract is concentrated, dried and crushed to obtain the peony extract.

[0042] The chrysanthemum extract, chuanxiong extract and peony extract used in the following examples were prepared according to Basic Examples 1-3, respectively.

[0043] Example 1: A supramolecular repair essence and its preparation method The invention comprises the following components in parts by weight: 0.4 parts of supramolecular composition, 4 parts of chrysanthemum extract, 1 part of chuanxiong extract, 2 parts of peony extract, 16 parts of hyaluronic acid, 2 parts of seaweed polysaccharide and 60 parts of water.

[0044] The preparation method of the supramolecular composition is as follows: (1) Dissolve hydroxypropyl α-cyclodextrin in water, then add calendulin and ligustilide, and stir at 60°C for 3 h to obtain a mixed solution; (2) The mixed solution is spray-dried to obtain the supramolecular composition.

[0045] The mass ratio of the hydroxypropyl α-cyclodextrin, calendula, ligustilide and water is 85:12:3:250.

[0046] The preparation method of the supramolecular repair essence comprises the following steps: S1, mixing a moisturizing agent and water to obtain a mixture, S2. Add the supramolecular composition and the plant extract to the mixture obtained in step S1 and mix them evenly to obtain the supramolecular repair essence.

[0047] Example 2: A supramolecular repair essence and its preparation method The invention comprises the following components in parts by weight: 0.2 parts of supramolecular composition, 3 parts of chrysanthemum extract, 1 part of chuanxiong extract, 1 part of peony extract, 10 parts of hyaluronic acid, 2 parts of seaweed polysaccharide and 45 parts of water.

[0048] The preparation method of the supramolecular composition is as follows: (1) Dissolve hydroxypropyl α-cyclodextrin in water, then add calendulin and ligustilide, and stir at 60°C for 3 h to obtain a mixed solution; (2) The mixed solution is spray-dried to obtain the supramolecular composition.

[0049] The mass ratio of the hydroxypropyl α-cyclodextrin, calendula, ligustilide and water is 80:9:3:200.

[0050] The preparation method of the supramolecular repair essence comprises the following steps: S1, mixing a moisturizing agent and water to obtain a mixture, S2. Add the supramolecular composition and the plant extract to the mixture obtained in step S1 and mix them evenly to obtain the supramolecular repair essence.

[0051] Example 3: A supramolecular repair essence and its preparation method The preparation comprises the following components by weight: 0.5 parts of supramolecular composition, 6.25 parts of chrysanthemum extract, 1.25 parts of chuanxiong extract, 2.5 parts of peony extract, 18 parts of hyaluronic acid, 2 parts of seaweed polysaccharide and 75 parts of water.

[0052] The preparation method of the supramolecular composition is as follows: (1) Dissolve hydroxypropyl α-cyclodextrin in water, then add calendulin and ligustilide, and stir at 60°C for 3 h to obtain a mixed solution; (2) The mixed solution is spray-dried to obtain the supramolecular composition.

[0053] The mass ratio of the hydroxypropyl α-cyclodextrin, calendula, ligustilide and water is 90:15:3:300.

[0054] The preparation method of the supramolecular repair essence comprises the following steps: S1, mixing a moisturizing agent and water to obtain a mixture, S2. Add the supramolecular composition and the plant extract to the mixture obtained in step S1 and mix them evenly to obtain the supramolecular repair essence.

[0055] Comparative Example 1: A repair essence and its preparation method The difference from Example 1 is that no supramolecular composition is used, that is: The repair essence comprises the following components by weight: 0.3 parts of calendula, 0.1 parts of ligustilide, 4 parts of chrysanthemum extract, 1 part of chuanxiong extract, 2 parts of peony extract, 16 parts of hyaluronic acid, 2 parts of seaweed polysaccharide and 60 parts of water.

[0056] The preparation method of the supramolecular repair essence comprises the following steps: S1, mixing a moisturizing agent and water to obtain a mixture, S2. Add calenduladin, ligustilide and plant extract to the mixture obtained in step S1 and mix evenly to obtain the supramolecular repair essence.

[0057] Comparative Example 2: A supramolecular repair essence and its preparation method The difference from Example 1 is that ligustilide is omitted, that is: The preparation method of the supramolecular composition is as follows: (1) Dissolve hydroxypropyl α-cyclodextrin in water, then add calendula, and stir at 60°C for 3 hours to obtain a mixed solution; (2) The mixed solution is spray-dried to obtain the supramolecular composition.

[0058] The mass ratio of the hydroxypropyl α-cyclodextrin, calendula and water is 85:15:250.

[0059] The rest is the same as Example 1.

[0060] Comparative Example 3: A supramolecular repair essence and its preparation method The difference from Example 1 is that the mass ratio of hydroxypropyl α-cyclodextrin, calendula, ligustilide and water is 85:3:12:250, and the rest is the same as Example 1.

[0061] Comparative Example 4: A supramolecular repair essence and its preparation method The difference from Example 1 is that the chrysanthemum extract is replaced by rose extract, and the rest is the same as Example 1.

[0062] Effect experiment: 1. Irritation testing

[0063] A total of 70 subjects were selected for the allergy patch test according to GB17149-1-1997 and divided into 7 groups of 10 subjects each. The essences (0.5 g) prepared in Examples 1-3 and Comparative Examples 1-4 were applied to the inner forearm of the subject using non-irritating adhesive tape, with one side serving as the control area and the other as the experimental area. The essences were evenly applied to the skin using the palm of the hand. After 24 hours, the patch tester was removed. After a 30-minute interval, the skin reaction was observed after the indentation disappeared. If the result was negative, the skin was observed again 48 hours after the patch test. The number of subjects who developed a light red spot was recorded. (Note: The skin patch test is divided into 5 levels based on allergy status, with a light red spot being a weaker positive reaction. Therefore, if 10% or more of the subjects develop a light red spot, the product is considered to be susceptible to allergies. If the percentage is less than 10%, it indicates that the product is not susceptible to allergies. The lower the number of subjects, the lower the allergenic potential of the cosmetic.) The test results are shown in Table 1 below.

[0064] Table 1

[0065] According to the test results in Table 1 above, it can be seen that the supramolecular repair essences prepared in Examples 1-3 of the present invention are non-sensitizing, while in Comparative Example 1, the essence obtained without using a supramolecular composition has a higher allergenicity, and in Comparative Example 2, only calendulin is used as the active ingredient of the supramolecular composition, or the mass ratio of calendulin and ligustilide is changed, which will result in the essence having a higher allergenicity, that is, only the essence prepared by the method provided by the present invention has a lower irritation. Because the supramolecular composition encapsulates calendulin and ligustilide inside the molecule, it can be released slowly and steadily when released, thereby effectively reducing the irritation of the component itself. When the content of one component is significantly increased, the interaction between the components is weakened, which will cause a sudden release phenomenon during release, thereby causing sensitization.

[0066] 2. Moisturizing and repairing effect

[0067] 1) Test samples: the essences prepared in Examples 1-3 and Comparative Examples 1-4, and an aqueous solution as a blank control group.

[0068] 2) Volunteer screening: Three days before the start of the experiment, volunteers were screened using a lactic acid sting test. When the volunteers visited, they washed their faces with a designated cleanser and sat quietly in the test environment for about 20 minutes. After the meditation, 50 μL of a 10% lactic acid aqueous solution was dropped onto a filter paper with a diameter of 8 mm and placed on the subject's nasolabial groove and either cheek (or on both sides of the subject's nasolabial groove). The subjects were asked about their subjective symptoms after 30 seconds, 2.5 minutes, and 5 minutes, and the symptoms were scored using a 4-point system (0 for no feeling, 1 for mild, 2 for moderate, and 3 for severe). The sum of the sting scores at 2.5 minutes and 5 minutes, i, ≥ 3, was considered positive for lactic acid sting.

[0069] 3) Test method: Fifty-one volunteers with lactic acid stinging were screened and randomly assigned to each group of three. The product was applied to the face every morning and evening for a total of four weeks. Relevant data were collected and summarized at 0 weeks, 2 weeks, and 4 weeks. The results are shown in Table 2.

[0070] 4) Test indicators: The transepidermal water loss (TEWL) value is used to evaluate the skin barrier function and is an important parameter for examining skin repair after using the product. The smaller the value, the better the skin barrier and the better the repair.

[0071] 5) Lactic acid sting score: The skin was scored on a 4-point scale (0 for no feeling, 1 for mild, 2 for moderate, and 3 for severe). The higher the score, the more sensitive the skin.

[0072] Judgment result: If any of the above indicators is significantly improved before and after use, it is considered to have a soothing and desensitizing effect. The lower the lactic acid stinging score after use, the higher the product's repair ability is considered.

[0073] Table 2

[0074] According to the test results in Table 2 above, the present invention, through the specific selection of the supramolecular composition + plant extract + moisturizer, while limiting the specific ingredients and ratios of each component, can quickly increase the water retention of the stratum corneum in the short term, improve the molting phenomenon, strengthen the barrier function in the long term, reduce the amount of water loss from the skin, effectively repair the barrier function of the skin, and reduce the sensitivity of the skin.

[0075] According to the test results of Example 1 and Comparative Example 1, the present invention can be more conducive to the penetration of plant extracts and active ingredients into the skin through the selection of supramolecular compositions, can be better absorbed by the skin, and has better anti-inflammatory, antibacterial, antipruritic, skin softening and acne prevention effects.

[0076] According to the test results of Example 1 and Comparative Examples 2-3, the combined effect of calendulin and ligustilide in the supramolecular composition of the present invention can help promote the penetration of various plant extract components, improve the absorption effect of skin cells on repair molecules, the antioxidant function of plant extract components, and help reduce the irritation of the components themselves, thereby long-term improving the moisturizing and repair functions of the skin.

[0077] According to the test results of Example 1 and Comparative Example 4, the type of plant extract will also affect the repair effect of the essence to a certain extent.

[0078] 3. Antibacterial effect

[0079] The essences prepared in Examples 1-3 and Comparative Examples 1-4 were subjected to a Propionibacterium acnes antibacterial experiment.

[0080] The specific operations are as follows: (1) After acne patients clean their faces with water and facial cleansing products, they should strictly disinfect the affected area with 75% alcohol three times, squeeze out the contents of the acne with a sterile cotton swab, and immediately place them in a sterile test tube for low-temperature storage; (2) Each sample was dipped into the acne contents using a sterile inoculating loop and inoculated onto a brain heart infusion (BHI) agar plate using the streak method. After inoculation, the plate was immediately placed in an anaerobic culture bag containing an anaerobic gas-producing bag. An oxygen indicator (the indicator turns blue when exposed to oxygen and pink in an anaerobic environment) was placed in the bag. At the same time, an aerobic culture control sample was set up and placed in a 37°C constant temperature biochemical incubator for 72h-96h.

[0081] (3) After 2 hours, it can be seen that the bacteria in the anaerobic medium grow well, while the bacteria in the aerobic medium hardly grow. Pick out a single colony from the anaerobic medium and transfer it to BHI liquid medium. Add 40% sterile glycerol and store it in a -80°C refrigerator for later use. Prepare the other part into a bacterial suspension for later use.

[0082] (4) Using a UV spectrophotometer, adjust the bacterial suspension to OD600 = 0.6-0.8. Take 100 μL of the bacterial suspension and spread it on a BHI agar plate. After drying, place filter paper pieces sterilized by high temperature at equal intervals. Place an equal amount of the essence prepared in Examples 1-3 and Comparative Examples 1-4 on the plate. Incubate at 37°C in an anaerobically controlled environment for 24 h-48 h. Observe the antibacterial effect. Perform three sets of experiments in parallel. The average of all the results is shown in Table 3.

[0083] Table 3 Propionibacterium acnes inhibition zone test results

[0084] According to the test results in Table 3 above, the essences prepared in Examples 1-3 of the present invention all have good anti-Propionibacterium acnes effects. The size of the inhibition zone can reach more than 15 mm after 24 hours of culture, and the size of the inhibition zone can reach more than 20 mm after 36 hours of culture.

[0085] In Comparative Example 1, the supramolecular structure was not used. The resulting essence had good antibacterial properties after 24 hours of culture, with the inhibition zone size reaching more than 15 mm. However, the inhibition zone size after 36 hours of culture was significantly smaller than that of Examples 1-3, indicating that the absence of a supramolecular structure would affect the antibacterial durability of the essence.

[0086] In Comparative Example 2-3, changing the mass ratio of calendulain and ligustilide in the supramolecular composition will affect the joint action of calendulain and ligustilide, thereby weakening the antibacterial effect.

[0087] In Comparative Example 4, replacing the chrysanthemum extract with rose extract weakens the antibacterial effect, indicating that the type of plant extract will also affect the antibacterial performance of the essence to a certain extent.

[0088] Obviously, the described embodiments are only individual embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other implementations obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

Claims

1. A supramolecular repair essence, characterized by: The components include the following by weight: 0.2-0.5 parts of supramolecular composition, 5-10 parts of plant extract, 10-20 parts of moisturizing agent and 40-80 parts of water; The preparation method of the supramolecular composition is as follows: (1) Dissolve hydroxypropyl α-cyclodextrin in water, then add calendulin and ligustilide, and stir at 60°C for 3 h to obtain a mixed solution; (2) The mixed solution is spray-dried to obtain the supramolecular composition.

2. The supramolecular repair essence according to claim 1, characterized in that: The supramolecular repair essence comprises the following components by weight: 0.35-0.4 parts of supramolecular composition, 7-8 parts of plant extract, 15-18 parts of moisturizer and 60-70 parts of water.

3. The supramolecular repair essence according to claim 1, characterized in that: The mass ratio of calendulin and ligustilide is 3-5:

1.

4. The supramolecular repair essence according to claim 1, characterized in that: The mass ratio of the hydroxypropyl α-cyclodextrin, calendula, ligustilide and water is 80-90:9-15:3:200-300.

5. The supramolecular repair essence according to claim 4, characterized in that: The mass ratio of the hydroxypropyl α-cyclodextrin, calendula, ligustilide and water is 85:12:3:

250.

6. The supramolecular repair essence according to claim 1, characterized in that: The plant extract is a mixture of chrysanthemum extract, chuanxiong extract and peony extract; the mass ratio of the chrysanthemum extract, chuanxiong extract and peony extract is 3-5:1:1-2.

7. The supramolecular repair essence according to claim 6, characterized in that: The mass ratio of the chrysanthemum extract, the chuanxiong extract and the peony extract is 4:1:

2.

8. The supramolecular repair essence according to claim 1, characterized in that: The moisturizing agent is a mixture of hyaluronic acid and seaweed polysaccharide, and the mass ratio of the hyaluronic acid to the seaweed polysaccharide is 5-10:

1.

9. The supramolecular repair essence according to any one of claims 1 to 8, characterized in that: The composition comprises the following components by weight: 0.4 parts of supramolecular composition, 4 parts of chrysanthemum extract, 1 part of chuanxiong extract, 2 parts of peony extract, 16 parts of hyaluronic acid, 2 parts of seaweed polysaccharide and 60 parts of water; The preparation method of the supramolecular composition is as follows: (1) Dissolve hydroxypropyl α-cyclodextrin in water, then add calendulin and ligustilide, and stir at 60°C for 3 h to obtain a mixed solution; (2) spray-drying the mixed solution to obtain the supramolecular composition; The mass ratio of the hydroxypropyl α-cyclodextrin, calendula, ligustilide and water is 85:12:3:

250.

10. The method for preparing the supramolecular repair essence according to any one of claims 1 to 9, characterized in that: The steps include: S1, mixing a moisturizing agent and water to obtain a mixture, S2. Add the supramolecular composition and the plant extract to the mixture obtained in step S1 and mix them evenly to obtain the supramolecular repair essence.

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