Chinese herbal medicine preparation for treating avian infectious bronchitis virus variant infection

Abstract

The invention provides a Chinese herbal medicine preparation for treating avian infectious bronchitis virus variant infection, and relates to the technical field of medicine preparation. The Chinese herbal medicine preparation for treating avian infectious bronchitis virus variant infection is prepared from the following components in parts by weight: 12-20 parts of gynostemma pentaphyllum, 8-12 parts of fructus forsythiae, 4-8 parts of folium isatidis, 4-8 parts of honeysuckle, 12-20 parts of platycodon grandiflorum, 8-12 parts of perillaseed, 4-8 parts of codonopsis pilosula, 4-8 parts of scutellaria baicalensis and 4-8 parts of radix sophorae flavescentis. The Chinese herbal medicines are decocted into liquid medicine to feed poultry, bronchitis and complications caused by virus variant infection can be effectively treated, the physique of the poultry is enhanced, the immunity of the poultry is improved, the death rate of the poultry is reduced, the Chinese herbal medicines are decocted into the liquid medicine, feeding is easy, cost is low, and the Chinese herbal medicines are suitable for large-scale popularization and application. Even if the composition is taken for a long time, drug resistance generated in poultry bodies is low, and drug property residual quantity is small.

Description

Technical Field

[0001] The invention relates to the technical field of drug preparation, in particular to a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus. Background Art

[0002] Avian bronchitis is an acute, highly contagious respiratory infection caused by the infectious bronchitis virus (IBDV) of the coronavirus genus. Avian bronchitis can be transmitted to susceptible birds through airborne droplets expelled from the respiratory tract of infected birds. The virus can also be transmitted through the digestive tract via contaminated feed, water, and cages. Various factors, such as overheating, severe cold, crowding, poor ventilation, and insufficient vitamin and mineral supply, can contribute to the development of the disease. Chickens of all ages are susceptible, but symptoms are more pronounced in birds under five weeks of age, with a mortality rate of 15% to 19%. The disease is most common from late autumn to late spring, with winter being the most severe. The natural incubation period for avian bronchitis is typically 36 hours or longer. Chicks may suddenly become ill, presenting with respiratory symptoms such as runny nose, tearing, nasal swelling, coughing, sneezing, and panting with the neck stretched and the mouth open. As the disease progresses, symptoms may worsen, leading to head and eyes being withdrawn, wings drooping, huddling, loss of appetite, and increased thirst. When laying hens are infected, their egg production will decrease and they may produce soft and deformed eggs.

[0003] Currently, the main drugs used to treat avian infectious bronchitis virus variant infections are generally antiviral antibiotics. However, these drugs are prone to forming drug resistance in poultry after excessive feeding and the drug properties remain in the body of poultry, which is not conducive to long-term use and the cost of the drugs is high. Summary of the Invention

[0004] (1) Technical problems solved

[0005] In response to the shortcomings of the existing technology, the present invention provides a Chinese herbal medicine preparation for treating infection by variant strains of avian infectious bronchitis virus, which solves the problems that antibiotics easily form drug resistance in poultry after excessive feeding and the drug properties remain in the body of poultry, which is not conducive to long-term use, and the cost of the drugs is high.

[0006] (2) Technical solution

[0007] To achieve the above objectives, the present invention is implemented through the following technical scheme: a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus, comprising the following ingredients in a weight ratio: 12-20 parts of Gynostemma pentaphyllum, 8-12 parts of Forsythia suspensa, 4-8 parts of Isatis indigotica, 4-8 parts of Honeysuckle, 12-20 parts of Platycodon grandiflorum, 8-12 parts of Perilla seed, 4-8 parts of Codonopsis pilosula, 4-8 parts of Scutellaria baicalensis and 4-8 parts of Sophora flavescens.

[0008] Preferably, the following ingredients are included in the following proportions by weight: 20 parts of Gynostemma pentaphyllum, 12 parts of Forsythia suspensa, 8 parts of Isatis indigotica, 8 parts of Honeysuckle, 20 parts of Platycodon grandiflorum, 12 parts of Perilla seeds, 8 parts of Codonopsis pilosula, 8 parts of Scutellaria baicalensis and 8 parts of Sophora flavescens.

[0009] Preferably, the following ingredients are included in the following weight ratio: 18 parts of Gynostemma pentaphyllum, 11 parts of Forsythia suspensa, 7 parts of Isatis indigotica, 7 parts of Honeysuckle, 18 parts of Platycodon grandiflorum, 11 parts of Perilla seed, 7 parts of Codonopsis pilosula, 7 parts of Scutellaria baicalensis and 7 parts of Sophora flavescens.

[0010] Preferably, the following ingredients are included in the following weight ratio: 16 parts of Gynostemma pentaphyllum, 10 parts of Forsythia suspensa, 6 parts of Isatis indigotica, 6 parts of Honeysuckle, 16 parts of Platycodon grandiflorum, 10 parts of Perilla seed, 6 parts of Codonopsis pilosula, 6 parts of Scutellaria baicalensis and 6 parts of Sophora flavescens.

[0011] Preferably, the following ingredients are included in the following weight ratios: 14 parts of Gynostemma pentaphyllum, 9 parts of Forsythia suspensa, 5 parts of Isatis indigotica, 5 parts of Honeysuckle, 14 parts of Platycodon grandiflorum, 9 parts of Perilla seeds, 5 parts of Codonopsis pilosula, 5 parts of Scutellaria baicalensis and 5 parts of Sophora flavescens.

[0012] Preferably, the following ingredients are prepared by weight: 12 parts of Gynostemma pentaphyllum, 8 parts of Forsythia suspensa, 4 parts of Isatis indigotica, 4 parts of Honeysuckle, 12 parts of Platycodon grandiflorum, 8 parts of Perilla seeds, 4 parts of Codonopsis pilosula, 4 parts of Scutellaria baicalensis and 4 parts of Sophora flavescens.

[0013] A method for preparing a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus comprises the following specific steps:

[0014] S1. Wash Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens with clean water and place in a beaker for later use;

[0015] S2. Pour three times the total weight of Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens into a beaker and boil;

[0016] S3. When the water in the beaker evaporates to one third of the initial amount, stop boiling and filter the raw materials in the beaker;

[0017] S4. Finally, take out the filtered liquid.

[0018] Preferably, the boiling temperature of S3 is 100 degrees, and the boiling time is 2-2.5 hours.

[0019] Beneficial effects

[0020] The present invention provides a Chinese herbal medicine preparation for treating infection by variant strains of avian infectious bronchitis virus.

[0021] It has the following beneficial effects:

[0022] 1. The present invention uses herbal medicine to boil into a medicine liquid and then feeds it to poultry, which can effectively treat bronchitis and complications caused by virus variant infection, enhance the physique of poultry, improve the poultry's own immunity, and reduce the mortality rate of poultry.

[0023] 2. The present invention uses herbal medicine to boil into medicine, which is simple to feed and low in cost. Even if the medicine is taken for a long time, the drug resistance produced in the body of the poultry is low and the drug residue is small. DETAILED DESCRIPTION

[0024] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0025] Example 1:

[0026] The embodiment of the present invention provides a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus, comprising the following ingredients in a weight ratio: 20 parts of Gynostemma pentaphyllum, 12 parts of Forsythia suspensa, 8 parts of Isatis indigotica, 8 parts of Honeysuckle, 20 parts of Platycodon grandiflorum, 12 parts of Perilla seed, 8 parts of Codonopsis pilosula, 8 parts of Scutellaria baicalensis, and 8 parts of Sophora flavescens.

[0027] Among them, Gynostemma pentaphyllum has the effects of clearing away heat and detoxifying, relieving sore throat and swelling, and has a significant preventive and inhibitory effect on infectious bronchitis virus;

[0028] Forsythia has the effects of clearing away heat and detoxifying, reducing swelling and dispersing stagnation;

[0029] Isatis indigo leaf has the effects of clearing away heat and detoxifying, cooling blood and stopping bleeding;

[0030] Honeysuckle has the effects of clearing away heat and detoxifying, cooling blood and reducing swelling;

[0031] Platycodon grandiflorum has the effects of moistening the lungs and relieving coughs, relieving sore throats and improving voice, and has a significant preventive and inhibitory effect on infectious bronchitis viruses;

[0032] Perilla seeds have the effects of moistening the lungs and relieving coughs, lowering qi and resolving phlegm, and moistening the intestines and promoting bowel movements.

[0033] Codonopsis has the effects of replenishing qi, promoting body fluid, nourishing blood and calming the mind;

[0034] Scutellaria baicalensis has the effects of clearing away heat and dampness, purging fire and detoxifying;

[0035] Sophora flavescens has the effects of clearing away heat and dampness, killing insects and relieving itching;

[0036] A method for preparing a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus comprises the following specific steps:

[0037] S1. Wash Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens with clean water and place in a beaker for later use;

[0038] S2. Pour three times the total weight of Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens into a beaker and boil;

[0039] S3. When the water in the beaker evaporates to one third of the initial amount, stop boiling and filter the raw materials in the beaker. The boiling temperature is 100 degrees and the boiling time is 2-2.5 hours;

[0040] S4. Finally, take out the filtered liquid.

[0041] Example 2:

[0042] The embodiment of the present invention provides a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus, comprising the following ingredients in a weight ratio: 18 parts of Gynostemma pentaphyllum, 11 parts of Forsythia suspensa, 7 parts of Isatis indigotica, 7 parts of Honeysuckle, 18 parts of Platycodon grandiflorum, 11 parts of Perilla seed, 7 parts of Codonopsis pilosula, 7 parts of Scutellaria baicalensis, and 7 parts of Sophora flavescens.

[0043] A method for preparing a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus comprises the following specific steps:

[0044] S1. Wash Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens with clean water and place in a beaker for later use;

[0045] S2. Pour three times the total weight of Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens into a beaker and boil;

[0046] S3. When the water in the beaker evaporates to one third of the initial amount, stop boiling and filter the raw materials in the beaker. The boiling temperature is 100 degrees and the boiling time is 2-2.5 hours;

[0047] S4. Finally, take out the filtered liquid.

[0048] Example 3:

[0049] The embodiment of the present invention provides a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus, comprising the following ingredients in a weight ratio: 16 parts of Gynostemma pentaphyllum, 10 parts of Forsythia suspensa, 6 parts of Isatis indigotica, 6 parts of Honeysuckle, 16 parts of Platycodon grandiflorum, 10 parts of Perilla seed, 6 parts of Codonopsis pilosula, 6 parts of Scutellaria baicalensis, and 6 parts of Sophora flavescens.

[0050] A method for preparing a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus comprises the following specific steps:

[0051] S1. Wash Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens with clean water and place in a beaker for later use;

[0052] S2. Pour three times the total weight of Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens into a beaker and boil;

[0053] S3. When the water in the beaker evaporates to one third of the initial amount, stop boiling and filter the raw materials in the beaker. The boiling temperature is 100 degrees and the boiling time is 2-2.5 hours;

[0054] S4. Finally, take out the filtered liquid.

[0055] Example 4:

[0056] The embodiment of the present invention provides a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus, comprising the following ingredients in a weight ratio: 14 parts of Gynostemma pentaphyllum, 9 parts of Forsythia suspensa, 5 parts of Isatis indigotica, 5 parts of Honeysuckle, 14 parts of Platycodon grandiflorum, 9 parts of Perilla seed, 5 parts of Codonopsis pilosula, 5 parts of Scutellaria baicalensis, and 5 parts of Sophora flavescens.

[0057] A method for preparing a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus comprises the following specific steps:

[0058] S1. Wash Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens with clean water and place in a beaker for later use;

[0059] S2. Pour three times the total weight of Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens into a beaker and boil;

[0060] S3. When the water in the beaker evaporates to one third of the initial amount, stop boiling and filter the raw materials in the beaker. The boiling temperature is 100 degrees and the boiling time is 2-2.5 hours;

[0061] S4. Finally, take out the filtered liquid.

[0062] Embodiment 5:

[0063] The embodiment of the present invention provides a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus, comprising the following ingredients in a weight ratio: 12 parts of Gynostemma pentaphyllum, 8 parts of Forsythia suspensa, 4 parts of Isatis indigotica, 4 parts of Honeysuckle, 12 parts of Platycodon grandiflorum, 8 parts of Perilla seed, 4 parts of Codonopsis pilosula, 4 parts of Scutellaria baicalensis, and 4 parts of Sophora flavescens.

[0064] A method for preparing a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus comprises the following specific steps:

[0065] S1. Wash Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens with clean water and place in a beaker for later use;

[0066] S2. Pour three times the total weight of Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens into a beaker and boil;

[0067] S3. When the water in the beaker evaporates to one third of the initial amount, stop boiling and filter the raw materials in the beaker. The boiling temperature is 100 degrees and the boiling time is 2-2.5 hours;

[0068] S4. Finally, take out the filtered liquid.

[0069] Comparative Example:

[0070] The difference from Example 1, Example 2, Example 3, Example 4 and Example 5 is that antibiotics, such as cefixime granules, are directly fed;

[0071] The preparations were prepared by the methods of Example 1, Example 2, Example 3, Example 4, Example 5 and the comparative example, and the preparations were fed to the birds respectively. The survival status of the birds was recorded 3 hours after taking the drugs within 4 days, and the blood of the birds was drawn and the drug residue was detected by an instrument to determine the therapeutic effect and drug resistance. The test results are shown in Table 1:

[0072] Table 1

[0073]

[0074] From the results in Table 1, it can be seen that the Chinese herbal medicine preparations for treating infection by variant strains of avian infectious bronchitis virus prepared by the methods of Example 1, Example 2, Example 3, Example 4, and Example 5 can significantly alleviate infectious bronchitis and complications in poultry until they completely disappear after long-term use, and also have a conditioning effect on the poultry body. After taking the preparations, there is always very little residual medicinal properties in the poultry body.

[0075] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus, characterized in that: The preparation comprises the following ingredients in a weight ratio: 12-20 parts of gynostemma pentaphyllum, 8-12 parts of forsythia, 4-8 parts of isatis indigotica, 4-8 parts of honeysuckle, 12-20 parts of platycodon, 8-12 parts of perilla seeds, 4-8 parts of codonopsis pilosula, 4-8 parts of scutellaria baicalensis and 4-8 parts of sophora flavescens.

2. A Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus according to claim 1, characterized in that: The invention comprises the following ingredients in a weight ratio: 20 parts of gynostemma pentaphyllum, 12 parts of forsythia suspensa, 8 parts of isatis indigotica, 8 parts of honeysuckle, 20 parts of platycodon grandiflorum, 12 parts of perilla seeds, 8 parts of codonopsis pilosula, 8 parts of scutellaria baicalensis and 8 parts of sophora flavescens.

3. The Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus according to claim 1, characterized in that: The invention comprises the following ingredients in a weight ratio: 18 parts of gynostemma pentaphyllum, 11 parts of forsythia, 7 parts of isatis indigotica, 7 parts of honeysuckle, 18 parts of platycodon, 11 parts of perilla seed, 7 parts of codonopsis pilosula, 7 parts of scutellaria baicalensis and 7 parts of sophora flavescens.

4. The Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus according to claim 1, characterized in that: The invention comprises the following ingredients in a weight ratio: 16 parts of gynostemma pentaphyllum, 10 parts of forsythia, 6 parts of isatis indigotica, 6 parts of honeysuckle, 16 parts of platycodon, 10 parts of perilla seed, 6 parts of codonopsis pilosula, 6 parts of scutellaria baicalensis and 6 parts of sophora flavescens.

5. The Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus according to claim 1, characterized in that: The invention comprises the following ingredients in a weight ratio: 14 parts of gynostemma pentaphyllum, 9 parts of forsythia suspensa, 5 parts of isatis indigotica, 5 parts of honeysuckle, 14 parts of platycodon grandiflorum, 9 parts of perilla seeds, 5 parts of codonopsis pilosula, 5 parts of scutellaria baicalensis and 5 parts of sophora flavescens.

6. The Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus according to claim 1, characterized in that: The invention comprises the following ingredients in a weight ratio: 12 parts of gynostemma pentaphyllum, 8 parts of forsythia, 4 parts of isatis indigotica, 4 parts of honeysuckle, 12 parts of platycodon, 8 parts of perilla seed, 4 parts of codonopsis pilosula, 4 parts of scutellaria baicalensis and 4 parts of sophora flavescens.

7. A method for preparing a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus, based on the Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus according to any one of claims 1 to 6, characterized in that: The specific steps include: S1. Wash Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens with clean water and place in a beaker for later use; S2. Pour three times the total weight of Gynostemma pentaphyllum, Forsythia suspensa, Isatis indigotica, Honeysuckle, Platycodon grandiflorum, Perilla seed, Codonopsis pilosula, Scutellaria baicalensis, and Sophora flavescens into a beaker and boil; S3. When the water in the beaker evaporates to one third of the initial amount, stop boiling and filter the raw materials in the beaker; S4. Finally, take out the filtered liquid.

8. The method for preparing a Chinese herbal medicine preparation for treating infection by a variant strain of avian infectious bronchitis virus according to claim 7, characterized in that: The cooking temperature of S3 is 100 degrees, and the cooking time is 2-2.5 hours.

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