External preparation for treating acne and preparation method thereof

Abstract

The invention discloses an external preparation for treating acne, which is prepared from the following Chinese herbal medicines in parts by weight: 2-8 parts of coptis chinensis, 3-12 parts of golden cypress, 3-12 parts of scutellaria baicalensis, 3-12 parts of fructus kochiae, 4-16 parts of honeysuckle, 4-16 parts of chrysanthemum, 4-16 parts of cortex dictamni, 2-8 parts of ligusticum wallichii, 4-16 parts of angelica sinensis, 2-8 parts of safflower, 2-8 parts of radix angelicae, 4-16 parts of cortex moutan, 4-16 parts of lithospermum, 2-8 parts of liquorice and 4-16 parts of dandelion. The preparation method comprises the following steps: removing impurities from the weighed Chinese herbal medicines, crushing, uniformly stirring, sieving with a 100-mesh sieve to obtain traditional Chinese medicine powder, blending the traditional Chinese medicine powder with boiled water into a slightly thin paste, and smearing for use. The external preparation developed by the invention can resist inflammation, control grease secretion, inhibit scar hyperplasia and reduce recurrence frequency, and has a remarkable treatment effect.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to an external preparation for treating acne and a preparation method thereof. Background Art

[0002] Acne is one of the most common chronic inflammatory skin diseases affecting the sebaceous follicles in adolescents. It is known as "powdery acne" in Traditional Chinese Medicine. Lesions are characterized by comedones, papules, pustules, nodules, cysts, and scars. Epidemiological studies show that 80-90% of adolescents experience acne. Acne often occurs on the face and is disfiguring, negatively impacting patients' studies, work, and personal lives, causing psychological distress and affecting their physical and mental health. The causes of acne are complex, and its pathogenesis is not yet fully understood. It is often linked to androgens, sebum secretion, the proliferation of Propionibacterium acnes, abnormal keratinization of the sebaceous ducts, psychological factors, and genetics. During puberty, the body's sex hormones increase or the levels of estrogen and androgen become unbalanced. Androgens increase the proliferation, synthesis, secretion and excretion of sebum by the sebaceous glands, and cause the keratinization and proliferation of the hair follicle infundibulum, resulting in blockage of the hair follicle opening. Sebum cannot be discharged smoothly, forming acne. At the same time, lipophilic Propionibacterium acnes multiplies in the hair follicles, esterase production increases, and triglycerides in lipids are broken down to produce free fatty acids that stimulate inflammatory reactions in and around the hair follicles, resulting in papules, pustules, nodules, cysts, etc. Acne has a complex etiology. Traditional Chinese Medicine (TCM) believes that it stems primarily from an excess of Yang-heat in the body, which in turn burns Yin-blood, transforming body fluid into phlegm, which in turn causes blood stasis, leading to the intertwining of phlegm and stasis. Excessive consumption of spicy, fatty, and sweet foods can lead to heat accumulation in the lungs and stomach, which then rises up the meridians and stagnates on the face. Emotional stimulation can stagnate liver-qi, which in turn transforms into fire, causing it to rise and stagnate on the face. A pre-existing yang deficiency or improper treatment can weaken the body's vital energy, spleen, and stomach, leading to a deficiency of the lower yang, which prevents the body from transporting and transforming body fluids to nourish the lungs and stomach. This causes the rise of deficient Yang to the face, and internal fire to stagnate, resulting in rashes. Traditional Chinese medicine texts and contemporary physicians generally believe that the development of acne is closely linked to the lungs, spleen, stomach, and large intestine, and is associated with pathogenic qi such as wind, heat, dampness, and cold. Over time, this can lead to stubborn pathogens such as phlegm and stasis, and is also related to constitution, diet, and emotions. The "Compendium of Surgery: Lung Wind and Alcohol-Induced Splinters" also states: "Lung wind is caused by stagnant blood heat in the lung meridian, which then causes alcohol-induced spikes." It is believed that wind-heat invades the body, or that a predisposing body to blood heat, or a preference for spicy, fatty, and sweet foods, contributes to internal heat. Over time, this heat accumulates in the blood, leading to blood heat stagnation and the development of acne. Currently, clinical treatments for acne primarily focus on the underlying mechanism. Common treatments include: 1) anti-androgen drugs, which primarily reduce facial sebum secretion by inhibiting androgen synthesis; 2) drugs that treat abnormal keratinization of the hair follicle duct, such as retinoids; and 3) anti-acne bacteria drugs, such as benzoyl peroxide, erythromycin, clindamycin, and tetracycline. While Western medicine can achieve some short-term efficacy, it also presents significant challenges. For example, the use of anti-androgen drugs can cause endocrine disruption; and the use of fast-acting anti-acne drugs can cause dry skin, flaking, erythema, and enlarged pores, with recurrences common after discontinuation. These findings indicate that current clinical acne treatments are limited in efficacy and lack a safe and effective treatment. Consequently, many acne patients require long-term, repeated treatments, ultimately resulting in noticeable scars that severely impact their appearance and self-confidence.Therefore, an external preparation for treating acne, which has low cost of Chinese medicinal raw materials, is easy to use, has no toxic side effects, and has significant therapeutic effects, and a method for using the same is developed. Summary of the Invention

[0003] In order to solve the problems existing in the background technology, the purpose of the present invention is to provide an external preparation for treating acne, which has low cost of Chinese medicinal raw materials, is easy to use, has no toxic side effects, and has significant therapeutic effects, and a method for using the same.

[0004] The external preparation for treating acne of the present invention is prepared from the following Chinese herbal medicines in the following weight ratios: 2-8 parts of coptis chinensis, 3-12 parts of phellodendron amurense, 3-12 parts of scutellaria baicalensis, 3-12 parts of kochia scoparia, 4-16 parts of honeysuckle, 4-16 parts of chrysanthemum, 4-16 parts of dittany, 2-8 parts of ligusticum, 4-16 parts of angelica sinensis, 2-8 parts of safflower, 2-8 parts of angelica dahurica, 4-16 parts of moutan bark, 4-16 parts of lithospermum officinale, 2-8 parts of liquorice, and 4-16 parts of dandelion.

[0005] Preferably, the external preparation is prepared from the following Chinese herbal medicines in the following weight ratio: 5 parts of Coptis chinensis, 8 parts of Phellodendron amurense, 8 parts of Scutellaria baicalensis, 10 parts of Kochia scoparia, 12 parts of Honeysuckle, 12 parts of Chrysanthemum, 10 parts of Dictamni, 5 parts of Chuanxiong, 10 parts of Angelica sinensis, 5 parts of Carthamus tinctorius, 6 parts of Angelica dahurica, 11 parts of Moutan bark, 13 parts of Lithospermum erythrorhizon, 6 parts of Licorice, and 13 parts of Taraxacum mongolicum.

[0006] Furthermore, the external preparation is a powdered mixture.

[0007] The preparation method and use method of the external preparation for treating acne of the present invention comprise the following steps: S1. Weigh coptis root, phellodendron amurense, scutellaria baicalensis, kochia fruit, honeysuckle, chrysanthemum, white peony root, ligusticum chuanxiong, angelica sinensis, safflower, angelica dahurica, moutan bark, lithospermum officinale, licorice and dandelion according to the formula ratio, remove impurities, put each Chinese herbal raw material into a grinder separately for grinding, and then stir the ground Chinese herbal raw materials evenly and pass them through a 100-mesh sieve to prepare Chinese medicine powder; S2. Take 30-40g of Chinese medicine powder and mix it with boiled water to form a slightly thin paste-like Chinese medicine facial mask. Preferably, the mass ratio of the Chinese medicine powder to boiled water is 30-40g:80g. After the Chinese medicine facial mask cools down, apply it evenly on the clean face. The thickness of the Chinese medicine facial mask is 2-3mm. Cover the Chinese medicine facial mask with a layer of plastic wrap. After applying the Chinese medicine facial mask for 20-30 minutes, rinse it with warm water. The cycle of applying the Chinese medicine facial mask is once a day, and 25 days is a course of treatment. The temperature of the boiled water is 80-90°C, the temperature of the Chinese medicine facial mask when cooled is 30-40°C, and the temperature of the warm water is 25-35°C. When applying the Chinese medicine facial mask on the face, be careful to avoid the eyes, nose, mouth and other parts. People who are allergic to the Chinese medicine ingredients in the Chinese medicine facial mask, and women who are breastfeeding or pregnant are prohibited from using it.

[0008] In the Chinese medicine preparation prepared by the present invention, the pharmacological agents and efficacy of various Chinese medicinal materials are as follows: Phellodendron chinense: Clears heat and dampness, purges fire and eliminates steam, detoxifies and treats sores. It is used for damp-heat diarrhea, jaundice, dark urine, vaginal discharge and itching, painful stranguria due to heat, beriberi and paralysis, bone steaming and fever, night sweats, spermatorrhea, sores and swelling, eczema and wet sores. It has anti-gout, antibacterial, antiviral, anti-allergic, anti-tumor, anti-inflammatory, sedative, and analgesic effects.

[0009] Scutellaria baicalensis: Clears heat and dampness, purges fire and detoxifies, stops bleeding, and stabilizes the fetus. It is used for damp-heat, summer-heat dampness, chest tightness and nausea, damp-heat fullness and distension, diarrhea, jaundice, lung-heat cough, high fever and thirst, vomiting and epistaxis due to blood heat, carbuncles, sores, and fetal restlessness. It has antibacterial, antiviral, anti-inflammatory, anti-allergic, anti-tumor, antioxidant, and anti-tumor effects. It also protects the cardiovascular, liver, and central nervous systems, scavenges free radicals, and enhances the body's immune function.

[0010] Kochia scoparia seeds: Clears heat and dampness, dispels wind and relieves itching. Used for painful urination, vaginal itching, leucorrhea, urticaria, eczema, and pruritus. Has hypoglycemic, anti-inflammatory, anti-allergic, anti-itching, anti-pathogen, antioxidant, anti-aging, and anti-cancer effects.

[0011] Honeysuckle: Clears heat and detoxifies, dispersing wind-heat. It is used for carbuncles, furuncles, sore throat, erysipelas, dysentery caused by heat toxins, wind-heat colds, and fevers caused by febrile diseases. It has anti-inflammatory, antipyretic, anti-tumor, antibacterial, antiviral, anti-aging, antioxidant, blood sugar-lowering, liver-protective, lung-protective, neuroprotective, immune-enhancing, and anti-platelet aggregation properties.

[0012] Chrysanthemum: Dispels wind and heat, soothes the liver and improves eyesight, and clears heat and detoxifies. It is used to treat wind-heat colds, headaches and dizziness, red and swollen eyes, blurred vision, and sores, carbuncles, and swelling. It improves myocardial nutrition, removes reactive oxygen free radicals, strengthens capillary resistance, reduces blood fat and cholesterol levels, inhibits tumors, slows aging, and enhances immunity.

[0013] Dictamni: Clears heat and dampness, dispels wind and detoxifies. Used for damp-heat sores, jaundice, eczema, rubella, scabies, scabies, rheumatic arthritis, jaundice, and dark urine. It has antibacterial, anti-tumor, anti-inflammatory, anti-allergic, anti-ulcer, anti-coronary atherosclerosis, and liver and nerve protection.

[0014] Chuanxiong: Promotes blood circulation and qi, dispels wind and relieves pain. It is used for chest pain, heart pain, stabbing pain in the chest and ribs, swelling and pain from falls, irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to abdominal masses, headaches, and rheumatic pain. It has anti-inflammatory, analgesic, anti-thrombotic, vasodilation-promoting, anti-asthmatic, anti-respiratory depression, anti-fibrosis, anti-obstructive disease, and anti-tumor effects.

[0015] Angelica sinensis: Tonifies and invigorates blood circulation, regulates menstruation and relieves pain, and moistens the intestines and promotes bowel movements. It is used for sallow complexion caused by blood deficiency, dizziness and palpitations, irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to deficiency and cold, rheumatic pain, injuries from falls, carbuncles, ulcers, and constipation caused by dry intestines. It has pharmacological effects such as promoting blood circulation, replenishing blood, antibacterial, regulating immune function, reducing muscle tension, providing antioxidant, anti-tumor, anti-depression, and tonifying the liver and kidneys.

[0016] Safflower: Promotes blood circulation and menstruation, dissipates blood stasis and relieves pain. It is used for amenorrhea, dysmenorrhea, lochia retention, lumps and swellings in the chest, heart pain due to stasis, stabbing pain in the chest and ribs, injuries from falls, and sores and swelling. It inhibits platelet formation, has antioxidant, anticoagulant, antithrombotic properties, and improves blood microcirculation.

[0017] Angelica dahurica: Dispels cold, dispels wind and relieves pain, clears the nasal passages, dries dampness and stops leukorrhea, and reduces swelling and discharges pus. It is used for colds and headaches, supraorbital pain, nasal congestion and runny nose, allergic rhinitis, sinusitis, toothache, leukorrhea, and sores and swelling. It has multiple effects, including antipyretic, analgesic, anti-inflammatory, anti-tumor, pathogenic microbial inhibition, skin whitening and antioxidant properties, central nervous system regulation, blood rheology improvement, and blood sugar lowering.

[0018] Cortex Moutan: Clears heat and cools blood, promoting blood circulation and removing blood stasis. It is used for heat invading the blood, fever-induced rashes, hematemesis and epistaxis, nighttime fever and morning chills, anorexia and bone steaming, amenorrhea, dysmenorrhea, injuries from falls, carbuncles, and sores. It has multiple effects, including anti-inflammatory, anti-tumor, anti-arrhythmic, hypoglycemic, immune system activation, and cardiovascular protection.

[0019] Lithospermum officinale: Clears heat and cools blood, promotes blood circulation and detoxifies, and clears rashes and eliminates freckles. It is used for excessive blood heat and toxicity, purple-black rashes, measles that do not clear up, sores, eczema, and burns caused by water or fire. It has antibacterial, anti-inflammatory, antiviral, anti-tumor, immunomodulatory, hepatoprotective, and antioxidant properties.

[0020] Licorice: Tonifies the spleen and replenishes Qi, clears heat and detoxifies, eliminates phlegm and relieves coughs, relieves pain, and harmonizes various medications. It is used to treat spleen and stomach deficiency, fatigue, palpitations and shortness of breath, cough with sputum, abdominal and limb cramps and pain, carbuncles, sores, and relieves drug toxicity and potency. It has antioxidant, anti-inflammatory, immune-regulating, anti-ulcer, detoxifying, anti-cancer, and anti-liver fibrosis properties.

[0021] Dandelion: Clears heat and detoxifies, reduces swelling and resolves stagnation, and acts as a diuretic and relieving stranguria. It is used for boils, breast abscesses, scrofula, conjunctivitis, sore throat, lung abscesses, intestinal abscesses, damp-heat jaundice, and painful stranguria caused by heat. It has antibacterial, antiviral, antioxidant, anti-inflammatory, anti-tumor, anti-hyperglycemic, gastrointestinal protective, and diuretic effects.

[0022] In the formula of the traditional Chinese medicine preparation, chrysanthemum is sweet and cold, nourishes yin, clears heat and detoxifies, and is especially good at detoxifying carbuncle; honeysuckle is sweet and cold in nature, good at clearing heat and detoxifying to treat sores, and the predecessors called it "the holy medicine for sores and ulcers, and it is the main medicine for treating all carbuncle and carbuncle Yang syndrome; coptis chinensis, scutellaria baicalensis, and phellodendron chinense are bitter and cold, clearing heat and dampness, purging fire and detoxifying. However, scutellaria baicalensis is good at clearing lung heat and damp heat in the liver and gallbladder, especially clearing damp heat in the middle and upper parts of the body; coptis chinensis is very bitter and cold, and is good at clearing heat and damp heat in the lungs and ... It is good at clearing damp-heat in the middle burner; Huangbai is good at clearing damp-heat in the lower burner. The three herbs are often used together. Their bitter and cold properties can directly eliminate the fire evil in the three burners and resolve the heat and toxicity. Dandelion also has the function of clearing heat and detoxifying. "Compendium of Materia Medica in Southern Yunnan" says: "It can be applied to various sores, swellings, scabies, ringworms, dispel wind, eliminate various sores and toxicity, disperse scrofula and tuberculosis, stop blood in urine, treat five types of stranguria, and benefit the bladder." It can also promote diuresis and relieve stranguria. When used together with Kochia scoparia, it can not only enhance the heat-clearing, damp-clearing and detoxifying effects; Kochia scoparia seeds enter the kidney and bladder meridians, reaching the bladder and promoting urinary tract drainage. Their combined use further enhances the bladder's function of clearing dampness and draining it downward through the bladder's urethra, embodying the principle of returning visceral pathogens to the bowels. However, using heat-clearing and detoxifying alone can hinder the dissipation of qi stagnation and blood stasis, leading to persistent swelling and knots. Therefore, angelica, Chuanxiong, safflower, lithospermum officinale, and peony bark are combined to promote qi, activate blood circulation, dissipate stasis, clear heat, cool blood, and relieve swelling and pain. For early-stage sores, pathogens are often trapped within the skin and pores. The pungent and dispersing white angelica root and the pungent and dispersing white peony bark are combined to dissipate stagnation and disperse knots, allowing heat and toxins to be expelled from the exterior. Licorice root is then added to tonify the spleen and replenish qi, clear heat and detoxify, and harmonize the various herbs. The entire formula combines both clearing and dispersing, focusing on heat-clearing and detoxifying, while simultaneously treating qi and blood and promoting blood circulation. Clearing heat and detoxifying also incorporates nourishing blood, activating blood circulation, and strengthening the body's health. Together, they achieve the effects of clearing heat and detoxifying, reducing swelling and hardening, and promoting blood circulation and relieving pain.

[0023] At the same time, the Chinese medicine preparation developed by the present invention is not a treatment method of oral administration or ointment, but a treatment method of applying a Chinese medicine facial mask on the face. The Chinese medicine facial mask is guided by the theory of traditional Chinese medicine, and is made by adding water to the above-mentioned Chinese medicinal material powder to form a paste, which is evenly applied to the face. Its greatest feature is that it is guided by the basic theory of traditional Chinese medicine, and the whole formula has the effects of clearing away heat and detoxifying, drying dampness and relieving itching, promoting blood circulation and removing blood stasis, and promoting pus drainage. It has pharmacological effects such as anti-inflammatory, antibacterial, anti-allergic, antioxidant, anti-aging, oil control, and accelerated blood circulation. The Chinese medicine facial mask for treating acne is a special treatment of traditional Chinese medicine, which is easy to operate, has obvious efficacy, few adverse reactions, and is safe and long-lasting. In addition, the Chinese medicine facial mask is simple and convenient, has few adverse reactions, is safe and effective, and promotes skin cell renewal and blood circulation by applying the medicine to the face.

[0024] The principle behind Chinese herbal mask treatments is that the short time a Chinese herbal mask is applied to the face temporarily isolates it from outside air and pollution, elevates skin temperature, dilates pores, stimulates sweat gland secretion and metabolism, and increases oxygen levels. This facilitates the excretion of metabolic products and accumulated oils from the epidermal cells, increases the concentration difference between the inner and outer layers of the stratum corneum, and thus enhances the stratum corneum's absorptive capacity. The sealing effect on the skin prevents sweat evaporation, enhancing stratum corneum hydration and accelerating drug absorption. Furthermore, Chinese herbal masks have an adhesive effect. Since they adhere tightly to the skin surface, they soften the keratinized layer of hair follicles. When the mask is removed, impurities are also removed, promoting patency of the hair follicles and smoothing the discharge of sebum, reducing or even preventing the formation of papules, pus, and cysts, and leaving the skin cleaner and more moisturized. Furthermore, the heat generated by the plaster cast of the mask accelerates local blood circulation, promoting the penetration and absorption of the active ingredients. Removing the mask also removes sebum and impurities from the follicles, facilitating sebum excretion. Clinical application has found that this method can effectively eliminate facial inflammation, increase microcirculation blood flow, promote wound recovery, reduce scars and pigmentation, and shorten the course of the disease. Traditional Chinese medicine cold mask has the effects of astringency, shrinking pores, anti-inflammatory and anti-infection.

[0025] Compared with traditional Western medicine clinical treatment, the advantages of this invention are: First, the Chinese medicine preparation developed by the present invention is prepared with more than ten kinds of Chinese medicines, and the medicines are synergistically formulated. The whole prescription has the effects of clearing away heat and detoxifying, drying dampness and relieving itching, promoting blood circulation and removing blood stasis, and promoting pus. It has pharmacological effects such as anti-inflammatory, antibacterial, anti-allergic, antioxidant, anti-aging, oil control, and accelerating blood circulation. At the same time, the developed Chinese medicine preparation adopts the treatment mode of applying a Chinese medicine mask on the face. The Chinese medicine mask is tightly attached to the skin surface and softens the keratinized layer of hair follicles. When the mask is removed, skin dirt can be removed together, which is conducive to the smooth discharge of skin hair follicles and the smooth discharge of sebum, reducing or even avoiding the formation of papules, pus, and cysts, making the skin cleaner and more moisturized, and can effectively eliminate facial inflammation, increase microcirculation blood flow, promote wound recovery, reduce scars and pigmentation, shorten the course of the disease, and has the advantages of simple use method, good treatment effect, and not easy to relapse; Secondly, the Chinese medicine preparation and usage method developed by the present invention can not only avoid the irritation to the gastrointestinal tract caused by oral administration and reduce the pain caused by taking medicine, but also greatly improve the patient's compliance and will not cause dependence on it; and the present invention adopts a pure Chinese medicine formula, without adding any chemical ingredients, no hormones, no irritation, long-term use without toxic side effects, in addition, will not cause drug resistance and dependence, can thoroughly fight inflammation, control oil secretion, inhibit scar hyperplasia, reduce the frequency of recurrence, improve the patient's psychological or social quality of life, and has good promotion and utilization value. DETAILED DESCRIPTION

[0026] The present invention is further described below with reference to the embodiments, but the present invention is not limited in any way. Any changes or substitutions made based on the teachings of the present invention fall within the scope of protection of the present invention. Example

[0027] The topical preparation for treating acne described in Example 1 is prepared from the following Chinese herbal medicines in the following weight ratios: 2 parts of coptis root, 3 parts of phellodendron, 3 parts of scutellaria, 3 parts of kochia fruit, 4 parts of honeysuckle, 4 parts of chrysanthemum, 4 parts of dittany bark, 2 parts of ligusticum, 16 parts of angelica, 8 parts of safflower, 8 parts of angelica root, 16 parts of moutan bark, 16 parts of lithospermum officinale, 8 parts of liquorice, and 16 parts of dandelion. The topical preparation is a powdered mixture.

[0028] The preparation and use of the topical preparation for treating acne described in Example 1 comprise the following steps: S1. Weigh coptis root, phellodendron amurense, scutellaria baicalensis, kochia fruit, honeysuckle, chrysanthemum, white peony root, ligusticum chuanxiong, angelica sinensis, safflower, angelica dahurica, moutan bark, lithospermum officinale, licorice and dandelion according to the formula ratio, remove impurities, put each Chinese herbal raw material into a grinder separately for grinding, and then stir the ground Chinese herbal raw materials evenly and pass them through a 100-mesh sieve to prepare Chinese medicine powder; S2. Take 30-40g of Chinese medicine powder and mix it with boiled water to form a slightly thin paste-like Chinese medicine facial mask. Preferably, the mass ratio of the Chinese medicine powder to boiled water is 30-40g:80g. After the Chinese medicine facial mask cools down, apply it evenly on the clean face. The thickness of the Chinese medicine facial mask is 2-3mm. Cover the Chinese medicine facial mask with a layer of plastic wrap. After applying the Chinese medicine facial mask for 20-30 minutes, rinse it with warm water. The cycle of applying the Chinese medicine facial mask is once a day, and 25 days is a course of treatment. The temperature of the boiled water is 80-90°C, the temperature of the Chinese medicine facial mask when cooled is 30-40°C, and the temperature of the warm water is 25-35°C. When applying the Chinese medicine facial mask on the face, be careful to avoid the eyes, nose, mouth and other parts. People who are allergic to the Chinese medicine ingredients in the Chinese medicine facial mask, and women who are breastfeeding or pregnant are prohibited from using it. Example

[0029] The topical preparation for treating acne described in Example 2 is prepared from the following Chinese herbal medicines in the following weight ratio: 5 parts of coptis chinensis, 8 parts of phellodendron amurense, 8 parts of scutellaria baicalensis, 10 parts of kochia scoparia, 12 parts of honeysuckle, 12 parts of chrysanthemum, 10 parts of dittany bark, 5 parts of ligusticum, 10 parts of angelica sinensis, 5 parts of safflower, 6 parts of angelica dahurica, 11 parts of moutan bark, 13 parts of lithospermum officinale, 6 parts of liquorice, and 13 parts of dandelion; the topical preparation is a powdered mixture.

[0030] The preparation and use of the topical preparation for treating acne described in Example 2 comprise the following steps: S1. Weigh coptis root, phellodendron amurense, scutellaria baicalensis, kochia fruit, honeysuckle, chrysanthemum, white peony root, ligusticum chuanxiong, angelica sinensis, safflower, angelica dahurica, moutan bark, lithospermum officinale, licorice and dandelion according to the formula ratio, remove impurities, put each Chinese herbal raw material into a grinder separately for grinding, and then stir the ground Chinese herbal raw materials evenly and pass them through a 100-mesh sieve to prepare Chinese medicine powder; S2. Take 30-40g of Chinese medicine powder and mix it with boiled water to form a slightly thin paste-like Chinese medicine facial mask. Preferably, the mass ratio of the Chinese medicine powder to boiled water is 30-40g:80g. After the Chinese medicine facial mask cools down, apply it evenly on the clean face. The thickness of the Chinese medicine facial mask is 2-3mm. Cover the Chinese medicine facial mask with a layer of plastic wrap. After applying the Chinese medicine facial mask for 20-30 minutes, rinse it with warm water. The cycle of applying the Chinese medicine facial mask is once a day, and 25 days is a course of treatment. The temperature of the boiled water is 80-90°C, the temperature of the Chinese medicine facial mask when cooled is 30-40°C, and the temperature of the warm water is 25-35°C. When applying the Chinese medicine facial mask on the face, be careful to avoid the eyes, nose, mouth and other parts. People who are allergic to the Chinese medicine ingredients in the Chinese medicine facial mask, and women who are breastfeeding or pregnant are prohibited from using it. Example

[0031] The topical preparation for treating acne described in Example 3 is prepared from the following Chinese herbal medicines in the following weight ratio: 8 parts of coptis chinensis, 12 parts of phellodendron amurense, 12 parts of scutellaria baicalensis, 12 parts of kochia scoparia, 16 parts of honeysuckle, 16 parts of chrysanthemum, 16 parts of dittany bark, 8 parts of ligusticum chuanxiong, 4 parts of angelica sinensis, 2 parts of safflower, 2 parts of angelica dahurica, 4 parts of moutan bark, 4 parts of lithospermum officinale, 2 parts of liquorice, and 4 parts of dandelion. The topical preparation is a powdered mixture.

[0032] The preparation and use of the topical preparation for treating acne described in Example 3 comprise the following steps: S1. Weigh coptis root, phellodendron amurense, scutellaria baicalensis, kochia fruit, honeysuckle, chrysanthemum, white peony root, ligusticum chuanxiong, angelica sinensis, safflower, angelica dahurica, moutan bark, lithospermum officinale, licorice and dandelion according to the formula ratio, remove impurities, put each Chinese herbal raw material into a grinder separately for grinding, and then stir the ground Chinese herbal raw materials evenly and pass them through a 100-mesh sieve to prepare Chinese medicine powder; S2. Take 30-40g of Chinese medicine powder and mix it with boiled water to form a slightly thin paste-like Chinese medicine facial mask. Preferably, the mass ratio of the Chinese medicine powder to boiled water is 30-40g:80g. After the Chinese medicine facial mask cools down, apply it evenly on the clean face. The thickness of the Chinese medicine facial mask is 2-3mm. Cover the Chinese medicine facial mask with a layer of plastic wrap. After applying the Chinese medicine facial mask for 20-30 minutes, rinse it with warm water. The cycle of applying the Chinese medicine facial mask is once a day, and 25 days is a course of treatment. The temperature of the boiled water is 80-90°C, the temperature of the Chinese medicine facial mask when cooled is 30-40°C, and the temperature of the warm water is 25-35°C. When applying the Chinese medicine facial mask on the face, be careful to avoid the eyes, nose, mouth and other parts. People who are allergic to the Chinese medicine ingredients in the Chinese medicine facial mask, and women who are breastfeeding or pregnant are prohibited from using it.

[0033] Acne, also known as "powdered acne" in Traditional Chinese Medicine, is a common, chronic inflammatory skin disease of the pilosebaceous glands. It manifests as comedones, papules, pustules, nodules, cysts, and may cause scarring. It often occurs on the face, chest, and back. Acne is a common, disfiguring facial skin disease in adolescents, varying degrees affecting patients' appearance, mental health, and quality of life. The "Suwen: Qi Tongtian Lun" states: "Exercise and sweating, exposed to wind, and a little cold cause chapped skin, and stagnation causes acne." Traditional Chinese Medicine believes that the disease is often caused by excessive yang heat in the body, accumulation of heat in the lung meridian, and the subsequent exposure to wind pathogens, which fumigate the face. It can also be caused by excessive consumption of spicy, fatty, and rich foods, which promotes dampness and heat, which then fuse and steams up the face. It can also be caused by spleen deficiency, impaired transport and transformation, internal accumulation of dampness and turbidity, which over time transforms into heat, scorching body fluids and transforming them into phlegm. Damp heat and phlegm stagnate in the skin, leading to the onset of the disease. As stated in the "Comprehensive Treatise on Surgery: Lung Wind and Alcohol-induced Splinters," "Lung wind is caused by blood heat and stasis in the lung meridian, leading to the formation of alcohol-induced spikes." Acne is believed to be caused by heat in the lung meridian, combined with stasis. Therefore, clinical treatment often focuses on the lungs, spleen, stomach, and other internal organs, as well as the pathological products of dampness, heat, phlegm, and blood stasis. Treatments typically focus on strengthening the spleen and dispelling dampness, resolving phlegm and blood stasis, and softening and dispersing hard masses. "External treatments must be similar to internal treatments; they must first address the root cause. What is the root? Understanding yin and yang and recognizing the internal organs." Traditional Chinese medicine (TCM) external treatments, guided by the theory of internal organs and meridians, also adhere to the principle of "treating the disease at its root." As the saying goes, "The principles of external treatment are the same as those of internal treatment, and the medicines used for external treatment are the same as those used for internal treatment; the only difference is the method." Traditional Chinese medicine has always upheld the principles of "differentiating symptoms to identify the cause, examining the cause and treating accordingly," and "treating the symptoms in an emergency and the root cause in a non-urgent manner." External treatments in TCM are known for their rapid effectiveness, remarkable efficacy, and few adverse reactions.

[0034] The external preparations developed in Examples 1 to 3 of the present invention can produce the effects of clearing away heat and detoxifying, drying dampness and relieving itching, promoting blood circulation and removing blood stasis, and promoting pus discharge. They have pharmacological effects such as anti-inflammatory, antibacterial, anti-allergic, antioxidant, anti-aging, oil control, and accelerated blood circulation. The treatment method of applying a Chinese medicine facial mask on the face is beneficial to the patency of skin hair follicles and the smooth discharge of sebum, reducing or even avoiding the formation of papules, pus, and cysts, making the skin cleaner and more moisturized, and can effectively eliminate facial inflammation, increase microcirculation blood flow, promote wound recovery, reduce scars and pigmentation, and have the advantages of simple use, good therapeutic effect, not easy to relapse, safety and no toxic side effects.

[0035] 1. Patient information Fifty clinical cases were collected based on clinical manifestations, including comedones, inflammatory and papules, pustules, and nodules and cysts. Twenty-five males and 25 females, aged 15 to 25 years, were included. According to the lesion classification guidelines for acne treatment, the clinical cases were categorized as mild (Grade I: comedones only), moderate (Grade II: inflammatory papules), and moderate (Grade III: pustules) in 25 cases, 18 cases in ...

[0036] 2. Criteria for determining efficacy: Cured: The facial acne area is reduced by ≥90%, and the facial skin is shiny; Markedly effective: The facial acne area is reduced by ≥60%, and the color becomes light red; Effective: The facial acne area is reduced by ≥30%, and the color is bright red; Ineffective: The facial acne area decreased by less than 30%, and the color change was not obvious.

[0037] 3. Treatment methods The topical preparation prepared in Example 1 of the present invention was used to treat 25 patients who met the criteria of mild disease, the topical preparation prepared in Example 2 of the present invention was used to treat 18 patients who met the criteria of moderate disease, and the topical preparation prepared in Example 3 of the present invention was used to treat 7 patients who met the criteria of severe disease. The treatment method is: apply the external preparation evenly on the face, wash it off with warm water after 20 to 30 minutes, treat once a day, 25 days as a course of treatment, treat a course of treatment, and follow up for one year.

[0038] Treatment effect After 25 days of treatment, the facial skin texture of 38 patients improved significantly, and the number of acne and papules decreased significantly. 26 patients were cured (the subjective symptoms disappeared completely and 90-100% of the wound surface recovered); 15 patients had significant improvement in symptoms and signs (60- 89%), which was markedly effective; 7 cases improved (subjective symptoms were significantly relieved, and skin lesions disappeared by more than 30-59%), which was effective. Among them, 2 patients with moderate acne (grade III: pustules) had obvious changes in acne scars, improved pigmentation, and a pink color, achieving the expected acne-removing and whitening effect.

[0039] Judging from the above-mentioned therapeutic effects, the topical preparation developed by the present invention has a good therapeutic effect on acne, promotes the relief of skin lesion symptoms, promotes the recovery of facial skin, avoids the irritation of chemical drugs to the skin and the drug resistance caused by long-term use, and the therapeutic effect is relatively significant.

[0040] Typical Cases Patient Chen, male, 23 years old, first visited the hospital on August 9, 2021. Chief complaint: facial papules, nodules, and cysts for 2 years. The patient complained that he went to Anhui to attend university 2 years ago and had red papules on his face. He went to the local hospital for treatment and was diagnosed with "acne". He was given "erythromycin ointment, twice a day". After taking the medicine for 1 month, there was no obvious improvement in the red papules on his face, and nodules and cysts gradually appeared. He went to many hospitals for treatment many times afterwards and was given "doxycycline capsules, minocycline capsules, compound glycyrrhizin tablets" orally, and "clindamycin gel" for external use, but the effect was not obvious. The nodules and cysts on his face were obviously painful, so he used "fusidic acid ointment, clindamycin metronidazole ointment" for external use, and took isotretinoin orally, one pill at a time, twice a day. After taking the medicine for 2 months, the pain of the red papules, nodules and cysts was slightly relieved, and new red papules and nodules continued to appear. The patient usually likes to eat meat and spicy food, likes quietness, is tired and weak, has sticky stools, regular urine, a dull tongue, a thick and greasy white tongue coating, and a deep and thin pulse. Specialist examination: Dense corn- and rice-sized papules can be seen on the forehead, cheeks, and mandible. Soybean-sized nodules and cysts can be seen with white pus heads on them. The skin temperature is slightly high. Soybean- and broad bean-sized cysts can be seen on the mandible. They are fluctuating and tender to the touch. A small amount of purulent secretions can be seen. Dark red pigmentation spots can be seen on the cheeks. The face secretes a lot of oil. Chinese medicine diagnosis: acne. Chinese medicine differentiation: spleen and stomach qi deficiency, exogenous evil toxins; Western medicine diagnosis: conglomerate acne. Treatment: Invigorate qi and strengthen the spleen, remove dampness and detoxify, stop using isotretinoin, pick and squeeze out the purulent secretions and white pus heads in the cysts, use 30-40g of the above-mentioned Chinese medicine powder, mix with boiling water to make a paste, let it cool and apply to the washed face with a thickness of 2-3mm, and cover the applied Chinese medicine mask with plastic wrap. After 30 minutes, remove the plastic wrap and Chinese medicine mask, wash the face, and irradiate with red and blue light for 10 minutes each, once a day. Treatment until August 16, 2021: The patient came for a follow-up visit one week later. The papules, nodules, and cysts on the face, forehead, cheeks, and mandible had partially subsided, the purulent secretions were significantly reduced, the pain was relieved, the tongue was dull, the tongue coating was thick and greasy white, and the pulse was slow. After continuing the above treatment for one course, the patient's facial skin texture was significantly improved, the number of acne and papules was significantly reduced, and 90-100% of the wound surface recovered, meeting the cure standard.

Claims

1. An external preparation for treating acne, characterized in that: The external preparation is prepared from the following Chinese herbal medicines in the following weight ratios: 2-8 parts of coptis chinensis, 3-12 parts of phellodendron amurense, 3-12 parts of scutellaria baicalensis, 3-12 parts of kochia scoparia, 4-16 parts of honeysuckle, 4-16 parts of chrysanthemum, 4-16 parts of dittany bark, 2-8 parts of chuanxiong, 4-16 parts of angelica sinensis, 2-8 parts of safflower, 2-8 parts of angelica dahurica, 4-16 parts of moutan bark, 4-16 parts of lithospermum officinale, 2-8 parts of liquorice, and 4-16 parts of dandelion.

2. The external preparation for treating acne according to claim 1, characterized in that: The external preparation is prepared from the following Chinese herbal medicines in the following weight ratio: 5 parts of coptis chinensis, 8 parts of phellodendron amurense, 8 parts of scutellaria baicalensis, 10 parts of kochia scoparia, 12 parts of honeysuckle, 12 parts of chrysanthemum, 10 parts of dittany bark, 5 parts of ligusticum, 10 parts of angelica sinensis, 5 parts of safflower, 6 parts of angelica dahurica, 11 parts of moutan bark, 13 parts of lithospermum officinale, 6 parts of liquorice, and 13 parts of dandelion.

3. A method for preparing an external preparation for treating acne according to claim 1 or 2, characterized in that: The steps include: S1. Weigh coptis root, phellodendron amurense, scutellaria baicalensis, kochia fruit, honeysuckle, chrysanthemum, white peony root, ligusticum chuanxiong, angelica sinensis, safflower, angelica dahurica, moutan bark, lithospermum officinale, licorice and dandelion according to the formula, remove impurities, and grind each Chinese herbal raw material separately in a grinder, then stir the ground Chinese herbal raw materials evenly and pass them through a 100-mesh sieve to prepare Chinese medicine powder; S2. Take 30-40g of Chinese medicine powder and mix it with boiling water to form a thin paste-like Chinese medicine facial mask. The thickness of the Chinese medicine facial mask is 2-3mm.

4. The method for preparing the external preparation for treating acne according to claim 3, characterized in that: The boiled water is water with a temperature of 80 to 90° C. after being boiled.

5. The method for preparing the external preparation for treating acne according to claim 3, characterized in that: The mass ratio of the traditional Chinese medicine powder to boiled water is 30-40g:80g.