Medicinal and edible composition for clearing away heart-fire and relieving restlessness as well as preparation method and application thereof

Abstract

The invention belongs to the field of health-care food, and particularly relates to a medicinal and edible composition for clearing away heart-fire and relieving restlessness as well as a preparation method and application thereof. The medicinal and edible composition is prepared from the following raw materials in parts by mass: 5 to 30 parts of radix asparagi, 2 to 15 parts of flos chrysanthemi, 5 to 10 parts of rhizoma imperatae, 2 to 5 parts of flos rosae rugosae, 3 to 10 parts of herba lophatheri and 3 to 6 parts of pericarpium citri reticulatae. The medicinal and edible composition for clearing away the heart-fire and relieving the restlessness has the effects of clearing away the heart-fire, relieving depression and relieving the restlessness, and soothing the nerves and helping sleep, and clinical research shows that the medicinal and edible composition for clearing away the heart-fire and relieving the restlessness can effectively improve the symptoms such as insomnia, dreaminess, palpitation, dysphoria, dry mouth, bitter mouth, oral ulcer and hypochondrium swelling and stuffiness caused by stagnation of liver qi and heart disturbing caused by fire.

Description

Technical Field

[0001] The present invention belongs to the field of health-care foods, and in particular relates to a medicine-food composite capable of clearing the heart and relieving restlessness, and a preparation method and application thereof. Background Art

[0002] With the changing lifestyles and pace of life in today's society, the incidence of various mental illnesses has increased by 30% to 50% compared to 20 years ago. Currently, people are increasingly concerned about a series of issues affecting their physical and mental health, such as irritability, palpitations, sleep disorders, dry mouth, bitter taste in the mouth, oral ulcers, and flank tightness, which are secondary to mood disorders. For symptoms such as irritability, palpitations, sleep disorders, dry mouth, bitter taste in the mouth, oral ulcers, and flank tightness secondary to mood disorders, traditional Chinese medicines primarily develop drugs to calm the mind and promote sleep, while Western medicine primarily focuses on sleep aids. Traditional sedatives and sleep aids, however, are mostly cold in nature and can easily deplete the spleen and stomach's yang energy, leading to adverse reactions such as fatigue, poor appetite, and recurrence of symptoms after discontinuation. Because these symptoms are not severe, patients generally prefer to take health foods or tea substitutes to improve their symptoms. However, the effects of health foods or substitute teas currently available on the market for symptoms such as irritability, palpitations, sleep disorders, dry mouth, bitter taste in the mouth, oral ulcers, and flank distension secondary to mood disorders are not satisfactory, and the symptoms cannot be significantly improved after taking them. Therefore, it is necessary to develop a health food or substitute tea with medicinal and edible properties that can effectively improve the above symptoms. Summary of the Invention

[0003] The first purpose of the present invention is to provide a medicine-food composition that can clear the heart and relieve restlessness. The second purpose of the present invention is to provide a method for preparing the medicine-food composition that can clear the heart and relieve restlessness. The third purpose of the present invention is to provide an application of the medicine-food composition that can clear the heart and relieve restlessness.

[0004] According to the first aspect of the present invention, a medicinal and edible composition for clearing the mind and relieving restlessness is provided, the raw materials of which include, by mass, 5-30 parts of asparagus cochinchinensis, 2-15 parts of chrysanthemum, 5-10 parts of cogongrass root, 2-5 parts of rose, 3-10 parts of bamboo leaves, and 3-6 parts of dried tangerine peel.

[0005] The present invention believes that emotional distress caused by work pressure, study pressure, and other reasons can lead to liver qi stagnation. Liver qi stagnation and the transformation of liver qi into fire are most likely to disturb the mind, resulting in symptoms such as irritability, palpitations, sleep disorders, dry mouth, bitter taste in the mouth, oral ulcers, and flank distension and tightness. Clearing and moistening heart fire, relieving depression and relieving restlessness are the main methods for treating these symptoms. The present invention uses clearing and moistening heart fire and soothing the liver to relieve depression as the treatment method.

[0006] In the prescription, asparagus cochinchinensis and chrysanthemum are the main drugs. Asparagus cochinchinensis has the effect of nourishing yin and moistening dryness, and enters the lung and kidney meridians. Chrysanthemum has the effect of calming the liver and clearing heat, and enters the lung and liver meridians. "Bielu" records that it can "eliminate chest heat and irritability". The two are used together to nourish kidney yin to reduce heart fire, clear liver heat to calm liver fire, and play the effect of nourishing yin and reducing fire, purging fire and eliminating irritability; Imperata root and bamboo leaf are the assistant drugs. Imperata root can clear heat and promote diuresis, and bamboo leaf enters the heart meridian. "Compendium of Materia Medica" believes that it can "eliminate heat and irritability, promote urination, and clear the heart", and has the effect of clearing heat, purging fire and promoting diuresis. The combination of the two herbs can guide the heart fire downward and enhance the effect of clearing the heart and purging fire. Rose flower is the guiding herb, and "Bencao Zaixin" records that it can "relieve the stagnation of liver and gallbladder qi, strengthen the spleen and reduce fire." It can not only promote qi and relieve depression to dredge liver qi, but also guide the medicine to the liver to clear and purge liver fire. Tangerine peel is the adjuvant herb, and "Bencao Fenjing" records that "Guang tangerine peel is pungent, bitter, and warm. ... It can promote qi and regulate the middle, eliminate phlegm and relieve diaphragm, promote the circulation of the five internal organs, and cure all diseases." It can strengthen the spleen and regulate qi. While regulating qi and relieving depression, it can also prevent the above-mentioned herbs from being too cold and damaging the spleen and stomach yang qi. The whole formula has the effects of clearing heart fire, regulating qi and relieving depression. It can effectively improve insomnia, frequent dreams, palpitations, irritability, dry mouth, bitter mouth, oral ulcers, and flank distension caused by liver qi stagnation and fire disturbing the heart.

[0007] The sources of raw materials for this recipe are as follows:

[0008] Asparagus: The dried tuberous root of Asparagus cochinchinensis (Lour.) Merr., a plant of the Liliaceae family.

[0009] Chrysanthemum: The dried inflorescence of Chrysanthemum morifolium Ramat., a plant of the Asteraceae family.

[0010] Imperata root: the rhizome of Imperata cylindrica Beauv.var.major (Nees) CE Hubb., a plant of the Poaceae family.

[0011] Rose: The dried flower buds of Rosa rugosa Thunb., a plant of the genus Rosa in the Rosaceae family.

[0012] Lophatherum gracile: dried stems and leaves of Lophatherum gracile Brongn., a plant of the genus Lophatherum in the Poaceae family.

[0013] Tangerine peel: the dried mature peel of Citrus reticulata Blanco and its cultivated varieties.

[0014] In some embodiments, the dosage form of the edible and medicinal composition for clearing the heart and eliminating the vexation is an oral solution, powder or granule.

[0015] In some embodiments, food-acceptable excipients may also be added.

[0016] In some embodiments, the auxiliary material is at least one of an excipient, a filler, a binder, a wetting agent, a disintegrant, an absorption enhancer, an adsorption carrier, a surfactant, and a lubricant.

[0017] According to a second aspect of the present invention, a method for preparing the above-mentioned edible and medicinal composition for clearing the mind and relieving restlessness is provided. When the dosage form of the edible and medicinal composition for clearing the mind and relieving restlessness is an oral solution, the preparation method comprises the following steps:

[0018] The raw materials are added to 8-12 times the weight of water and soaked for 20-40 minutes, then heated to boiling, kept slightly boiling for 1-2 hours, filtered, and the residue is repeatedly decocted 1-2 times, and the filtrate is combined to obtain the oral solution. After cooling, the oral solution is also packaged, thereby making it easy to carry and distribute.

[0019] According to a third aspect of the present invention, a method for preparing the above-mentioned edible and medicinal composition for clearing the mind and relieving restlessness is provided. When the dosage form of the edible and medicinal composition for clearing the mind and relieving restlessness is a powder, the preparation method comprises the following steps:

[0020] Crush or chop each raw material separately, then pass the crushed or chopped raw materials through 10-mesh and 50-mesh sieves respectively, continue to crush or chop the coarse particles that cannot pass through the 10-mesh sieve, take the powder between the 10-mesh sieve and the 50-mesh sieve, then mix the raw material powders according to the ratio, put them into the packaging bag, and seal it.

[0021] According to a fourth aspect of the present invention, there is provided the use of the aforementioned edible and medicinal composition for clearing the heart and relieving restlessness in the preparation of an edible and medicinal health food for ameliorating symptoms of liver stagnation and fire-disturbing the heart. Specifically, the symptoms of liver stagnation and fire-disturbing the heart include at least one of insomnia, frequent dreams, palpitations, irritability, dry mouth, bitter taste in the mouth, oral ulcers, and flank distension. The edible and medicinal health food includes edible and medicinal substitute teas, lozenges, and effervescent tablets.

[0022] The raw materials in the medicine-food combination of the present invention are all Chinese medicinal materials that can be used in health foods (Notice of the Ministry of Health on Further Standardizing the Management of Health Food Raw Materials (Weifajianfa

[2002] No. 51), and their sources are safe and reliable.

[0023] The raw materials of the medicine-food combination for clearing the mind and relieving restlessness of the present invention have the characteristics of medicine-food homology and safety in use, and can be prepared into medicine-food substitute tea, lozenges, effervescent tablets and other medicine-food homology health foods.

[0024] Illustratively, the preparation method of the edible and medicinal substitute tea includes the following steps: drying asparagus cochinchinensis, chrysanthemum, Imperata root, rose, bamboo leaf, and tangerine peel respectively until the moisture content is <3.0%, removing impurities and inferior raw materials, and after ultraviolet sterilization, weighing each raw material according to the raw material ratio and mixing them evenly to obtain the tea.

[0025] The obtained medicinal and edible substitute tea is packaged in a gauze tea bag and brewed with about 100 mL of warm water for drinking. The medicinal and edible substitute tea of the present invention has a good effect on improving symptoms such as insomnia, frequent dreams, palpitations, irritability, dry mouth, bitter taste in the mouth, oral ulcers, and flank distension and tightness caused by liver depression and fire disturbance, and is suitable for long-term drinking.

[0026] The beneficial effects of the present invention include:

[0027] (1) In the medicinal and edible composition for clearing the heart and relieving restlessness of the present invention, asparagus can nourish kidney yin and reduce heart fire; the heart is located in the upper part of the body, and chrysanthemum is light and clear, which can clear the heat in the upper part of the body, and chrysanthemum belongs to the liver meridian, which can clear the fire of the heart and liver at the same time; the combination of Imperata cylindrica and Bambusa longituba has the effect of clearing the heart and promoting diuresis, so that the fire is eliminated through urination; the combination of tangerine peel and rose has the effect of regulating qi and relieving depression, avoiding qi stagnation and turning into fire, and tangerine peel has the effect of warming the middle and drying dampness, avoiding the damage of cold medicines to the spleen and stomach.

[0028] (2) The medicinal and edible composition of the present invention has the effects of clearing away heart fire, relieving depression and irritability, calming the mind and promoting sleep. Clinical studies have shown that the medicinal and edible composition of the present invention can effectively improve the symptoms of insomnia, frequent dreams, palpitations, irritability, dry mouth, bitter taste in the mouth, oral ulcers, and flank distension caused by liver qi stagnation and fire disturbing the heart. DETAILED DESCRIPTION

[0029] The present invention will be further described in detail below in conjunction with specific examples. It is worth noting that the following examples are only for better explanation of the present invention and are not intended to limit the scope of protection of the present invention. The undisclosed process steps in the examples are prior art. Unless otherwise specified, the following raw materials are commercially available.

[0030] Example 1

[0031] The medicinal and edible oral solution for clearing the heart and relieving restlessness of the present embodiment is composed of the following raw materials: 5 grams of asparagus cochinchinensis, 2 grams of chrysanthemum, 5 grams of cogongrass root, 2 grams of rose, 3 grams of light bamboo leaf, and 3 grams of dried tangerine peel.

[0032] The preparation method comprises the following steps:

[0033] (1) Add 10 times the weight of the raw materials into water and soak for 30 minutes, then heat to boiling and keep it slightly boiling for 1 hour, and separate to obtain a first decoction and medicinal residue; take the medicinal residue obtained after the first decoction, add water equivalent to 8 times the total weight of the raw materials, heat to boiling, keep it slightly boiling for 1 hour, and separate to obtain a second decoction and medicinal residue; combine the first decoction and the second decoction to obtain an oral solution.

[0034] (2) Cool the resulting oral solution and then dispense it into small portions. This ratio is for one dose, which is approximately 150 mL.

[0035] Example 2

[0036] The medicinal and edible powder for clearing the heart and relieving restlessness of the present embodiment is composed of the following raw materials: 5 grams of asparagus cochinchinensis, 2 grams of chrysanthemum, 5 grams of cogongrass root, 2 grams of rose, 3 grams of light bamboo leaf, and 3 grams of dried tangerine peel.

[0037] The preparation method comprises the following steps:

[0038] (1) Grind the asparagus root and pass it through 10-mesh and 50-mesh sieves at the same time. Continue to grind the coarse particles that cannot pass through the 10-mesh sieve and take the powder between the 10-mesh sieve and the 50-mesh sieve;

[0039] (2) Grinding chrysanthemum, Imperata rhizome, rose, bamboo leaf and dried tangerine peel into powder according to the method of step (1);

[0040] (3) Mix all the raw material powders evenly, put them into a packaging bag, and seal it. When taking, take it with about 150mL of warm water.

[0041] Example 3

[0042] The medicinal and edible oral solution for clearing the heart and relieving restlessness of the present embodiment is composed of the following raw materials: 20 grams of asparagus cochinchinensis, 9 grams of chrysanthemum, 7 grams of cogongrass root, 3 grams of rose, 7 grams of light bamboo leaf, and 5 grams of dried tangerine peel.

[0043] The preparation method is the same as that of Example 1.

[0044] Example 4

[0045] The medicinal and edible powder for clearing the heart and relieving restlessness of the present embodiment is composed of the following raw materials: 30 grams of asparagus cochinchinensis, 15 grams of chrysanthemum, 10 grams of cogongrass root, 5 grams of rose, 10 grams of light bamboo leaf, and 6 grams of dried tangerine peel.

[0046] The preparation method is the same as that of Example 2.

[0047] Effect Examples

[0048] The medicinal and edible oral solution prepared in Example 1 for clearing the heart and relieving restlessness was taken by people suffering from liver depression and fire-disturbing heart. The dosage was as follows: one dose per day, each dose of about 150 mL, taken twice a day, morning and evening, for 5 consecutive days. The gender, age, initial diagnosis symptom information and follow-up symptom information of 54 patients suffering from liver depression and fire-disturbing heart from April 11, 2025 to April 28, 2025 were collected, and their main symptoms were scored.

[0049] The age of the 54 patients with liver depression and fire-disturbing heart syndrome was 23-77 years old, with an average age of 52 years old, including 19 males and 35 females. The main symptoms before taking the medicine included insomnia, dreaminess, palpitation, irritability, dry mouth, bitter taste in the mouth, oral ulcers, hypochondria and rib fullness, etc., which were divided into 4 levels according to the severity of the symptoms, and the scores were 1-4 points respectively. The symptoms of the 54 patients with liver depression and fire-disturbing heart syndrome before and after taking the medicinal and edible oral solution of Qingxin Chufan of Example 1 were compared, and the results are shown in Table 1 and Table 2.

[0050] Table 1 Statistical analysis of the effects of Qingxin Chufan oral solution on the symptoms of liver depression and fire disturbance in people

[0051]

[0052] Table 2 Statistical analysis of the effects of Qingxin Chufan oral solution on the symptoms of liver depression and fire disturbance in people

[0053]

[0054] As can be seen from Tables 1 and 2, the mean scores of insomnia, frequent dreams, palpitations, irritability, dry mouth, bitter taste in the mouth, oral ulcers, and flank distension and tightness in the group of people with liver depression and fire disturbance took the Qingxin Chufan oral solution of the present invention, which was significantly lower than those before taking the medicine (P<0.05), indicating that taking the Qingxin Chufan medicinal and edible composition of the present invention is significantly effective in improving the symptoms of insomnia, frequent dreams, palpitations, irritability, dry mouth, bitter taste in the mouth, oral ulcers, and flank distension and tightness in the group of people with liver depression and fire disturbance.

[0055] The above descriptions are only some specific embodiments of the present invention. For those skilled in the art, several modifications and improvements can be made without departing from the creative concept of the present invention, and these all fall within the scope of protection of the present invention.

Claims

1. A medicinal and edible composition for clearing the mind and relieving restlessness, characterized in that: The raw material composition comprises, by weight, 5-30 parts of asparagus cochinchinensis, 2-15 parts of chrysanthemum, 5-10 parts of cogongrass root, 2-5 parts of rose, 3-10 parts of bamboo leaves and 3-6 parts of dried tangerine peel.

2. The medicinal and edible composition for clearing the mind and relieving restlessness according to claim 1, characterized in that: The dosage form of the medicine-food homologous composition for clearing the heart and relieving restlessness is oral solution, powder or granule.

3. The medicinal and edible composition for clearing the mind and relieving restlessness according to claim 1 or 2, characterized in that: Food-acceptable excipients may also be added.

4. The medicinal and edible composition for clearing the mind and relieving restlessness according to claim 3, characterized in that: The auxiliary material is at least one of an excipient, a filler, a binder, a wetting agent, a disintegrant, an absorption promoter, an adsorption carrier, a surfactant, and a lubricant.

5. The method for preparing the medicine-food composition for clearing the mind and relieving restlessness according to any one of claims 1 to 4, characterized in that: When the dosage form of the medicine-food homologous composition for clearing the heart and relieving restlessness is an oral solution, the preparation method thereof comprises the following steps: The raw materials are added into 8-12 times of water by weight and soaked for 20-40 minutes, then heated to boiling and kept slightly boiling for 1-2 hours, filtered, and the residue is repeatedly decocted 1-2 times, and the filtrate is combined to obtain the product.

6. The method for preparing the medicine-food composition for clearing the mind and relieving restlessness according to any one of claims 1 to 4, characterized in that: When the dosage form of the medicine-food homologous composition for clearing the heart and relieving restlessness is a powder, the preparation method thereof comprises the following steps: Crush or chop each raw material separately, then pass the crushed or chopped raw materials through 10-mesh and 50-mesh sieves respectively, continue to crush or chop the coarse particles that cannot pass through the 10-mesh sieve, take the powder between the 10-mesh sieve and the 50-mesh sieve, then mix the raw material powders according to the ratio, put them into the packaging bag, and seal it.

7. Use of the food-medicine combination for clearing the heart and relieving restlessness according to any one of claims 1 to 4 in the preparation of a food-medicine combination health food for improving the symptoms of liver depression transforming into fire and disturbing the heart.

8. The use according to claim 7, characterized in that The symptoms of liver depression transforming into fire and disturbing the heart include at least one of insomnia, frequent dreams, palpitations, irritability, dry mouth, bitter taste in the mouth, oral ulcers, and distension and tightness in the ribs.

9. The use according to claim 7 or 8, characterized in that The medicine-food health-care food comprises medicine-food substitute tea, lozenges and effervescent tablets.

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