Sampling tool bit, sampling assembly and biological tissue sampling device

Abstract

The invention provides a sampling tool bit, a sampling assembly and a biological tissue sampling device. The sampling tool bit comprises a plurality of cutting pieces and a connecting piece for connecting the plurality of cutting pieces, wherein the cutting piece is of a tubular structure, a columnar embolism piece is placed in the cutting piece, and the embolism piece can move in the cutting piece along the axis of the cutting piece so that a biological tissue sample in the cutting piece can be ejected out; the connecting piece comprises a plurality of connecting caps connected in sequence, first through holes penetrating through the connecting caps are formed in the connecting caps, and the first end of each cutting piece is inserted into the first through hole of the corresponding connecting cap. The sampling tool bit solves the problems that in the prior art, due to the fact that a sampling forceps tool bit is repeatedly used, cross contamination of biological tissue samples is caused, and the sampling process of the biological tissue samples is tedious in operation, poor in sampling efficiency and the like.

Description

Technical Field

[0001] The invention belongs to the technical field of biological tissue sampling, and in particular relates to a sampling cutter head of a biological tissue sampling device, a sampling component of the biological tissue sampling device and a biological tissue sampling device. Background Art

[0002] In the use of existing biological tissue sampling devices, the cap of the sample collection tube is usually opened in advance and set aside for use. Then, the biological tissue sample is cut by pressing with sampling forceps. The cut biological tissue sample is then manually placed into the sample collection tube and the tube cap is screwed on to complete the entire sampling process. During the entire sampling process, the cutting head of the sampling forceps is fixed. When sampling multiple biological tissues, it will be reused, resulting in cross-contamination. Moreover, the frequent opening and closing of the tube cap and the insertion of biological tissue samples are required. On the one hand, it is easy to cause cross-contamination of biological tissue samples. On the other hand, it is cumbersome to operate, affecting sampling efficiency. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to provide a sampling blade, a sampling assembly and a biological tissue sampling device to solve the problems in the prior art such as the repeated use of sampling forceps blades leading to cross contamination of biological tissue samples, the cumbersome operation of the biological tissue sample sampling process, and poor sampling efficiency.

[0004] In order to solve or improve the above technical problems to a certain extent, according to one aspect of the present invention, a sampling cutter head of a biological tissue sampling device is provided, comprising: a plurality of cutting members and a connecting member for connecting the plurality of cutting members;

[0005] The cutting member is a tubular structure, a columnar plug is placed inside the cutting member, and the plug can move along the axis of the cutting member in the cutting member to eject the biological tissue sample in the cutting member;

[0006] The connecting member includes a plurality of connecting caps connected in sequence, wherein a first through hole is formed on the connecting cap, and the first end of each cutting member is inserted into the first through hole of the corresponding connecting cap.

[0007] In some embodiments, a weak portion is provided between each two connected connecting caps, and the weak portion will break when subjected to an external force in a preset direction.

[0008] In some embodiments, the cutting member and the connecting cap are interference-fitted, and the cutting member can move along the axis of the first through hole under the action of an external force.

[0009] In some embodiments, a cutting edge is formed at the second end of the cutting member, and a wall thickness of the cutting edge gradually decreases from the first end of the cutting member toward the second end of the cutting member.

[0010] In some embodiments, an angle is formed between the inner wall and the outer wall of the cutting edge, and the angle is less than or equal to 45 degrees.

[0011] In some embodiments, the angle is less than or equal to 30 degrees.

[0012] According to one embodiment of the present invention, a sampling assembly of a biological tissue sampling device is provided, comprising a sample collection tube and a sampling blade head according to any one of the above embodiments, which are independently arranged from each other;

[0013] A second through hole is formed in the sample collection tube, and the diameter of at least a portion of the second through hole is equal to the outer diameter of the cutting piece, so that the cutting piece can seal one end of the sample collection tube after extending into the second through hole, and the other end of the sample collection tube is detachably connected to a tube cap.

[0014] In some embodiments, the second through hole includes a first section and a second section that are connected, wherein the diameter of the first section is equal to the outer diameter of the cutting member, the diameter of the second section is greater than the diameter of the first section, and the length of the cutting member is greater than the length of the first section, so that after the cutting member passes through the first section, a portion of the cutting member is located in the second section.

[0015] In some embodiments, a tube cap is detachably connected to one end of the sample collection tube to seal the opening of the second through hole away from the first section. A sealing member is provided in the first section of the second through hole, which cooperates with the tube cap to form a sealed space in the second through hole.

[0016] In some embodiments, the sealing member is a consumable member, and when the cutting member extends into the first section, the sealing member is damaged by the cutting member, so that a portion of the cutting member can extend into the second section.

[0017] In some embodiments, the sealing member is an elastic member, and when the cutting member extends into the first section, the cutting member pushes the sealing member into the second section, so that part of the cutting member can extend into the second section.

[0018] According to one embodiment of the present invention, there is provided a biological tissue sampling device, comprising a sampler and the sampling assembly according to any one of the above embodiments;

[0019] Wherein, the sampling blade and the sample collection tube are both detachably connected to the sampler, and during the sampling process, the sampler includes a first driving state and a second driving state;

[0020] Wherein, in the first driving state, the sampler drives the sampling cutter head to move toward the sample collection tube. After the sampling cutter head obtains the biological tissue sample, the sampling cutter head is connected to the sample collection tube so that the obtained biological tissue sample is in the sample collection tube, and one end of the sample collection tube is blocked by the cutting member of the sampling cutter head;

[0021] In the second driving state, the sampler drives the sampling cutter head to move toward one side, so that the next cutting member is connected to the sampler.

[0022] In some embodiments, in the first driving state, after the cutting member of the sampling cutter head is driven to extend into the sample collection tube, the plugging member is driven to move toward the sample collection tube to push the biological tissue sample in the cutting member into the sample collection tube.

[0023] In some embodiments, the sampler includes a first driving member and a first pushing member, wherein the first pushing member includes a first-stage push rod and a second-stage push rod, and the first-stage push rod is sleeved on the outside of the second-stage push rod. When the sampler is in the first driving state, the first driving member drives the first-stage push rod and the second-stage push rod to move synchronously to push the cutting member into the sample collection tube. When the first-stage push rod moves a preset distance, the first driving member drives the second-stage push rod to continue moving, driving the embolic member to move toward the direction of the sample collection tube, so as to push the biological tissue sample in the cutting member into the sample collection tube.

[0024] In some embodiments, the sampler includes a second driving member and a second pushing member. When the sampler is in the second driving state, the second driving member drives the second pushing member to move to drive the sampling cutter head to move toward one side, so that the next cutting member is connected to the sampler.

[0025] The present invention has significant advantages and beneficial effects compared to the prior art. By utilizing the above technical solutions, the sampling blade, sampling assembly, and biological tissue sampling device of the present invention can achieve considerable technological advancement and practicality, and have wide industrial application value. It has at least the following advantages:

[0026] The multiple cutting elements of the sampling blade of the biological tissue sampling device of the present invention are connected to form an integral structure via a connector. During continuous sampling, the cutting elements can be automatically replaced, eliminating the need to manually replace the cutting elements after each sampling session. This avoids cross-contamination caused by frequent replacement of cutting elements, effectively saving time in replacing cutting elements and improving sampling efficiency. During the sampling process, the sampling assembly of the biological tissue sampling device directly seals one end of the sample collection tube with the cutting element, eliminating the need to remove the cutting element after a single sampling session. This effectively saves sampling time and improves the efficiency of biological tissue sampling.

[0027] The above description is only an overview of the technical solution of the present invention. In order to more clearly understand the technical means of the present invention, it can be implemented in accordance with the contents of the specification. In order to make the above and other purposes, features and advantages of the present invention more obvious and easy to understand, the following preferred embodiments are specifically cited and described in detail with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 This is a schematic structural diagram of a sampling blade of a biological tissue sampling device according to an embodiment of the present invention;

[0029] Figure 2 for Figure 1 The schematic diagram of the structure of the sampling cutter head shown is a partial enlarged schematic diagram of area A;

[0030] Figure 3 This is a schematic structural diagram of a sample collection tube of a sampling assembly of a biological tissue sampling device according to an embodiment of the present invention;

[0031] Figure 4 This is a schematic structural diagram of a sampling assembly of a biological tissue sampling device according to an embodiment of the present invention in use;

[0032] Figure 5 FIG. 4 is a structural block diagram of a biological tissue sampling device according to an embodiment of the present invention.

[0033] Reference numerals:

[0034] 1. Sampling head

[0035] 10. Cutting pieces

[0036] 100. Blade

[0037] 12. Connectors

[0038] 120. Connecting cap

[0039] 1200, first through hole

[0040] 122. Weak Points

[0041] 14. Embolic parts

[0042] θ, angle

[0043] 2. Sample collection tube

[0044] 20. Pipe cap

[0045] 22. Second through hole

[0046] 220, first paragraph

[0047] 222, second paragraph

[0048] 24. Seals

[0049] 3. Biological tissue samples

[0050] 4. Sampler

[0051] 40. First driving member

[0052] 41. First pusher

[0053] 42. Second driving member

[0054] 43. Second pusher DETAILED DESCRIPTION

[0055] To further illustrate the technical means and effects of the present invention to achieve the intended purpose, the following detailed description of the specific implementation and effects of the sampling blade, sampling assembly, and biological tissue sampling device proposed in accordance with the present invention is given in conjunction with the accompanying drawings and preferred embodiments.

[0056] The present invention connects the sampling blades of multiple biological tissue sampling devices through a connecting piece, and can realize automatic replacement of the sampling blade heads during the biological tissue sampling process, thereby realizing one-to-one sampling of the sampling blade heads and avoiding cross-infection of biological tissue samples. In addition, during the replacement process, there is no need to remove the used sampling blade heads and install new sampling blade heads. On the one hand, it avoids the problem of cross-infection of biological tissues caused by frequent operations, and on the other hand, it effectively improves the replacement speed of the sampling blade heads and improves the working efficiency of biological tissue sampling.

[0057] The embodiment of the present invention provides a sampling blade of a biological tissue sampling device, such as Figure 1 The sampling cutter head 1 includes a plurality of cutting pieces 10 and a connecting piece 12 for connecting the plurality of cutting pieces 10 .

[0058] The cutting piece 10 is used for cutting biological tissue, and the connecting piece 12 is used for connecting a plurality of cutting pieces 10 to form a whole structure to form a row of sampling blade heads 1 .

[0059] like Figure 1As shown, the cutting member 10 is a tubular structure with openings at both ends. Preferably, the cutting member 10 is a circular tubular structure. Of course, the cutting member 10 can also be configured as a rectangular tubular structure, a polygonal tubular structure, etc. The present invention is not limited to a specific tubular structure.

[0060] In some embodiments, in order to ensure that the biological tissue can be cut smoothly and to ensure the structural strength of the cutting member 10, the cutting member 10 is made of metal material. Preferably, the cutting member 10 is made of stainless steel.

[0061] In some embodiments, the inner diameter of the tubular cutting member 10 is less than or equal to 5 mm, and its length is less than or equal to 30 mm. Of course, the size of the cutting member 10 can also be adjusted according to different application scenarios and different usage requirements, and the present invention is not limited to the specific size of the cutting member 10.

[0062] In some embodiments, in order to ensure the smooth cutting of biological tissue and avoid the situation where incomplete cutting leads to sampling failure, Figure 2 As shown, a cutting edge 100 is formed on one end (i.e., the second end) of the cutting member 10. In the direction from the other end (i.e., the first end) of the cutting member 10 toward the end (i.e., the second end) where the cutting edge 100 is located, the wall thickness of the cutting edge 100 gradually decreases.

[0063] In this embodiment, the cutting edge 100 is formed on the cutting member 10 by gradually reducing the wall thickness of one end of the cutting member 10 , which can effectively reduce the resistance when cutting biological tissue and ensure smooth cutting of the biological tissue.

[0064] In some embodiments, the cutting edge 100 of the cutting piece 10 can be formed by gradually reducing the wall thickness from the outer wall toward the inner wall of the cutting piece 10, or by gradually reducing the wall thickness from the inner wall toward the outer wall of the cutting piece 10.

[0065] Preferably, the cutting edge 100 of the cutting element 10 is formed by gradually decreasing the wall thickness from the outer wall toward the inner wall of the cutting element 10. In this way, the outer diameter of the cutting element 10 at the cutting edge 100 can be reduced, thereby making it easier for the cutting element 10 to be inserted into the sample collection tube 2 after cutting is completed.

[0066] Optionally, an angle θ formed between the outer wall and the inner wall at the position of the cutting edge 100 of the cutting element 10 is less than or equal to 45 degrees.

[0067] Preferably, the angle θ formed between the outer wall and the inner wall at the position of the cutting edge 100 of the cutting member 10 is less than or equal to 30 degrees, so as to minimize the cutting resistance when cutting biological tissue.

[0068] In some embodiments, as Figure 1 As shown, a cylindrical plug 14 is placed inside the tubular cutting member 10. The specific shape of the plug 14 matches the tubular structure of the cutting member 10. For example, when the cutting member 10 is a circular tubular structure, the plug 14 is a cylindrical structure; when the cutting member 10 is a rectangular tubular structure, the plug 14 is a rectangular columnar structure.

[0069] Optionally, the plugging member 14 is placed inside the cutting member 10, forming a clearance fit with the cutting member 10 so that the plugging member 14 can move inside the cutting member 10 along the axis of the cutting member 10. It should be noted that when the cutting member 10 is used to cut biological tissue, the cut biological tissue sample 3 will remain inside the cutting member 10, and the plugging member 14, which can move along the axis of the cutting member 10, will push the biological tissue sample 3 out and drop it into the sample collection tube 2.

[0070] In some specific embodiments, the diameter of the plugging member 14 is slightly smaller than the inner diameter of the cutting member 10. For example, the difference between the inner diameter of the cutting member 10 and the diameter of the plugging member 14 is greater than 0 and less than or equal to 0.1 mm. By setting the diameter of the plugging member 14 slightly smaller than the inner diameter of the cutting member 10, the relative position between the plugging member 14 and the cutting member 10 can be accurately maintained, providing precise support and positioning. At the same time, the plugging member 14 can move axially along the cutting member 10 when subjected to external forces.

[0071] In some embodiments, the length of the plugging member 14 is less than or equal to 25 mm, that is, the length of the plugging member 14 is less than the length of the cutting member 10 .

[0072] In some embodiments, the plug 14 is made of plastic material, such as polyethylene, polypropylene, ABS (Acrylonitrile Butadiene Styrene, a terpolymer of acrylonitrile-butadiene-styrene), etc.

[0073] like Figure 1As shown, the connector 12 includes a plurality of sequentially connected connecting caps 120. Each connecting cap 120 is formed with a first through-hole 1200 extending therethrough. The shape of the first through-hole 1200 matches the tubular structure of the cutting member 10. For example, when the cutting member 10 is a circular tubular structure, the first through-hole 1200 is a circular through-hole; when the cutting member 10 is a rectangular tubular structure, the first through-hole 1200 is a rectangular through-hole. The number of connecting caps 120 matches the number of cutting members 10, and one end (i.e., the first end) of each cutting member 10 is inserted into the first through-hole 1200 of the corresponding connecting cap 120.

[0074] like Figure 1 As shown, when the first end of the cutting member 10 is inserted into the first through hole 1200 of the connecting cap 120, the first end can be flush with the connecting cap 120. Of course, the first end of the cutting member 10 can also protrude from the connecting cap 120.

[0075] There is a certain distance between two adjacent connecting caps 120 so that each cutting member 10 can operate independently without interfering with each other.

[0076] In some embodiments, a weak portion 122 is provided between each two connected connecting caps 120. The weak portion 122 can break when subjected to an external force in a predetermined direction, thereby allowing the cutting element 10 to be separated from the sampling blade head 1. Optionally, the external force applied to the weak portion 122 can be manually applied by an operator or applied by a mechanical structure, and the present invention is not limited thereto.

[0077] Optionally, on the connection portion connecting two adjacent connection caps 120, a portion of the connection portion is thinner than the other portion, and the portion with the thinner thickness forms a weak portion 122. When subjected to an external force, the portion with the thinner thickness will break.

[0078] Optionally, each adjacent connection cap 120 is connected by a fragile material to form a weak portion 122. The fragile material is easily damaged or broken under the action of external force. The fragile material includes but is not limited to brittle plastic (such as polystyrene, unplasticized polyvinyl chloride, etc.).

[0079] The present invention connects multiple cutting elements 10 via a connector 12 to form a single structure comprising multiple cutting elements 10, thereby forming a sampling head 1 of a biological tissue sampling device. When using this sampling head 1 for sampling, the next unused cutting element 10 can be manually or automatically moved to the cutting position after each sampling operation. This eliminates the need to disassemble and reassemble the sampling head 1 for each completed sampling operation. This greatly simplifies the entire biological tissue sampling process, improves sampling efficiency, and effectively avoids cross-contamination of the sampling head 1 due to frequent operation.

[0080] According to one embodiment of the present invention, a sampling assembly of a biological tissue sampling device is provided, such as Figure 1-4 As shown, the sampling assembly includes a sample collection tube 2 and a sampling cutter head 1 as described in any of the above embodiments, which are independently arranged.

[0081] like Figure 3 As shown, a second through hole 22 is formed in the sample collection tube 2, and the diameter of at least a portion of the second through hole 22 is equal to the outer diameter of the cutting member 10, so that the cutting member 10 can be inserted into the second through hole 22 to seal one end of the sample collection tube 2 during the sampling process. At the same time, a tube cap 20 is detachably connected to the other end of the sample collection tube 2. After sampling is completed, the cutting member 10 and the tube cap 20 can seal the second through hole 22 of the sample collection tube 2. Figure 4 shown.

[0082] Optionally, the tube cap 20 and the sample collection tube 2 may be connected by threaded connection, or by snap connection or other methods to achieve a detachable connection between the tube cap 20 and the sample collection tube 2 .

[0083] Optionally, identification information such as a QR code and a bar code is formed on the tube cap 20, and identification information such as a QR code, a bar code, and a digital number is formed on the outer wall of the sample collection tube 2, so that the sample collection tube 2 and the tube cap 20 can correspond to each other and to the sampled biological tissue through the above-mentioned identification information.

[0084] In one embodiment, if Figure 3 As shown, the second through hole 22 of the sample collection tube 2 includes a first section 220 and a second section 222. The diameter of the first section 220 is equal to the outer diameter of the cutting element 10 of the sampling blade 1. The diameter of the second section 222 is greater than the diameter of the first section 220. The length of the cutting element 10 is greater than the length of the first section 220 of the second through hole 22, so that after the cutting element 10 passes through the first section 220 of the second through hole 22, a portion of the cutting element 10 can be located within the second section 222 of the second through hole 22.

[0085] In this embodiment, the diameter of the first section 220 of the second through hole 22 is set to be the same as the outer diameter of the cutting element 10 of the sampling blade 1. This allows the insertion of the cutting element 10 to seal one end of the second through hole 22. It should also be noted that most biological tissues exhibit a certain degree of elasticity, which results in a certain degree of compression when sampled by the sampling blade 1. If the diameter of the entire second through hole 22 were the same as the outer diameter of the cutting element 10, when the biological tissue sample 3 is released into the sample collection tube 2, the biological tissue sample 3 would be pushed against the inner wall of the second through hole 22 due to its elasticity, causing it to become stuck within the second through hole 22. Therefore, setting the diameter of the second section 222 of the second through hole 22 larger than the diameter of the first section 220 can effectively solve the problem of the biological tissue sample 3 becoming stuck within the second through hole 22 due to its elasticity. In addition, the length of the first section 220 of the second through hole 22 is set to be smaller than the length of the cutting member 10, so that the biological tissue sample 3 can be released from the second section 222 of the second through hole 22, thereby preventing the biological tissue sample 3 from being stuck in the first section 220 of the second through hole 22.

[0086] Alternatively, as Figure 3 As shown, a sealing member 24 is provided in the first section 220 of the second through hole 22 of the sample collection tube 2. The unused sample collection tube 2 is sealed by the sealing member 24 and a detachably connected tube cap 20 provided at one end of the sample collection tube 2 to prevent leakage of the preservation solution or lysis solution filled in the sample collection tube 2 and contamination of the preservation solution or lysis solution.

[0087] In one embodiment, the seal 24 is a consumable part connected to the inner wall of the first section 220 of the second through hole 22 to seal one end of the sample collection tube 2. During the sample collection process, when the cutting element 10 of the sampling blade head 1 extends into the first section 220 of the second through hole 22, the cutting element 10 can easily destroy the consumable part, allowing the cutting element 10 to smoothly extend into the second section 222 of the second through hole 22, thereby releasing the biological tissue sample 3.

[0088] Preferably, the wearing part is a thin film structure, which can be made of rubber or plastic.

[0089] In one embodiment, the sealing member 24 is an elastic member that has an interference fit with the inner wall of the first section 220 of the second through hole 22. The elastic member abuts against the inner wall of the first section 220 of the second through hole 22, thereby sealing one end of the sample collection tube 2. During the sample collection process, when the cutting member 10 of the sampling cutter head 1 extends into the first section 220 of the second through hole 22, the cutting member 10 can easily push the sealing member 24 into the second section 222 of the second through hole 22, allowing it to smoothly extend into the second section 222 of the second through hole 22, thereby completing the release of the biological tissue sample 3. Figure 4 shown.

[0090] Preferably, the sealing member 24 is made of elastic materials such as rubber and silicone.

[0091] Optionally, the density of the sealing member 24 is lower than the density of the tubular preservation solution or lysis solution in the sample collection tube 2. When the sealing member 24 is pushed into the second section 222 of the second through hole 22, the sealing member 24 will press against the port of the cutting member 10 extending into the second section 222 of the second through hole 22 under the action of buoyancy, thereby sealing it, thereby further improving the sealing effect of the sample collection tube 2.

[0092] In some embodiments, multiple sample collection tubes 2 can be integrally connected via the connector described in any of the above embodiments, corresponding to the sampling blade head 1, to achieve continuous sampling without the need for manual replacement of the sample collection tubes 2.

[0093] According to one embodiment of the present invention, a biological tissue sampling device is provided. Figure 5 As shown, it includes a sampler 4 and a sampling component of the biological tissue sampling device described in any of the above embodiments.

[0094] The sampling blade 1 and the sample collection tube 2 of the sampling assembly are both detachably connected to the sampler 4. During the sampling process, the sampler 4 includes a first driving state and a second driving state.

[0095] When the sampler 4 is in the first driving state, the sampler 4 drives the sampling blade head 1 to move toward the sample collection tube 2. After the sampling blade head 1 obtains the biological tissue sample 3, the sampling blade head 1 is connected to the sample collection tube 2 so that the obtained biological tissue sample 3 is in the sample collection tube 2, and one end of the sample collection tube 2 is blocked by the sampling blade head 1.

[0096] Specifically, when the sampler 4 is in the first driving state, the sampling cutter head 1 is driven to move toward the sample collection tube 2. After the biological tissue sample 3 is obtained by the cutting member 10 of the sampling cutter head 1, the cutting member 10 is driven to extend into the second channel of the sample collection tube 2. After the cutting member 10 extends into the designated position of the second channel of the sample collection tube 2, the embolic member 14 built into the cutting member 10 is driven to move toward the sample collection tube 2, so that the biological tissue sample 3 in the cutting member 10 is pushed into the sample collection tube 2 by the embolic member 14.

[0097] In one embodiment, the sampler 4 includes a first driving member 40 and a first pushing member 41. The first pushing member 41 includes a first-stage push rod and a second-stage push rod, wherein the first-stage push rod is sleeved outside the second-stage push rod. When the sampler 4 is in a first driving state, the first driving member 40 drives the first-stage push rod and the second-stage push rod to move synchronously to push the cutting member 10 of the sampling cutter head 1 to a designated position in the sample collection tube 2. When the first-stage push rod moves to a preset distance (i.e., the cutting member 10 reaches the designated position in the sample collection tube 2), the first driving member 40 drives the second-stage push rod to continue moving, driving the plugging member 14 to move toward the sample collection tube 2, thereby pushing the biological tissue sample 3 in the cutting member 10 into the sample collection tube 2.

[0098] Optionally, the first pusher 41 can be driven electrically or manually. When the first pusher 41 is driven electrically, the first drive member 40 is a linear motor. When the first pusher 41 is driven manually, the first drive member 40 is a handle that drives the first pusher 41 using a lever. Driving the first pusher 41 using a handle is conventional technology and will not be described in detail here.

[0099] When the sampler 4 is in the second driving state, the sampler 4 drives the sampling cutter head 1 to move toward one side, so that the next cutting member 10 is connected to the sampler 4 .

[0100] Specifically, after completing a biological tissue sampling, the sampler 4 is controlled to enter the second driving state. When the sampler 4 is in the second driving state, the sampling cutter head 1 is driven to move toward one side by the distance required for the next cutting member 10 to complete the connection with the sampler 4. Under the drive of the sampler 4, the used cutting member 10 is disconnected from the sampler 4, and the next unused cutting member 10 is connected to the sampler 4. Then, after replacing the new sample collection tube 2, the next biological tissue collection can be carried out.

[0101] In some embodiments, the sampler 4 includes a second driving member 42 and a second pushing member 43. When the sampler 4 is in the second driving state, the second driving member 42 drives the second pushing member 43 to move, so as to drive the sampling cutter head 1 to move toward one side through the second pushing member 43, so that the next cutting member 10 is connected to the sampler 4.

[0102] Optionally, the second pusher 43 is a push rod, and the second driving member 42 is a linear motor. The linear motor drives the second pusher 43 to move to push the sampling cutter head 1 to move toward one side, thereby realizing the replacement of the cutting member 10.

[0103] Optionally, the second push member 43 is a friction wheel, the second driving member 42 is a stepper motor, the output shaft of the stepper motor is connected to the friction wheel to drive the friction wheel to rotate, the outer peripheral surface of the friction wheel is tangent to the sampling cutter head 1, and then the sampling cutter head 1 is driven to move toward one side by the rotation of the friction wheel, thereby realizing the replacement of the cutting member 10.

[0104] The multiple cutting pieces of the sampling blade of the biological tissue sampling device of the present invention are connected to form an integral structure via a connector. During continuous sampling, the cutting pieces can be automatically replaced, eliminating the need to replace the cutting pieces after each sampling operation. This avoids cross-contamination caused by frequent replacement of cutting pieces, effectively saves time in replacing cutting pieces, and improves sampling efficiency. During the sampling process, the sampling assembly of the biological tissue sampling device directly seals one end of the sample collection tube via the cutting piece. After a single sampling operation, there is no need to remove the cutting piece, effectively saving sampling time and improving sampling efficiency. Furthermore, multiple sample collection tubes can be connected to form an integral structure via a connector, enabling automatic replacement of the sample collection tubes during the sampling process, further improving sampling efficiency.

[0105] The above description is merely a preferred embodiment of the present invention and does not constitute any form of limitation to the present invention. Although the present invention has been disclosed as a preferred embodiment as above, it is not intended to limit the present invention. Any technician familiar with the present profession can make some changes or modifications to equivalent embodiments of the technical contents disclosed above without departing from the scope of the technical solution of the present invention. However, any simple modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A sampling blade of a biological tissue sampling device, characterized in that: include: a plurality of cutting members and a connecting member for connecting the plurality of cutting members; The cutting member is a tubular structure, a columnar plug is placed inside the cutting member, and the plug can move along the axis of the cutting member in the cutting member to eject the biological tissue sample in the cutting member; The connecting member includes a plurality of connecting caps connected in sequence, wherein a first through hole is formed on the connecting cap, and the first end of each cutting member is inserted into the first through hole of the corresponding connecting cap.

2. The sampling blade of the biological tissue sampling device according to claim 1, characterized in that: A weak portion is provided between each two connected connecting caps, and the weak portion will break when subjected to an external force in a preset direction.

3. The sampling blade of the biological tissue sampling device according to claim 1, characterized in that: The cutting member and the connecting cap are interference-fitted, and the cutting member can move along the axis of the first through hole under the action of an external force.

4. The sampling blade of the biological tissue sampling device according to any one of claims 1 to 3, characterized in that: A cutting edge is formed at the second end of the cutting piece, and a wall thickness of the cutting edge gradually decreases from the first end of the cutting piece toward the second end of the cutting piece.

5. The sampling blade of the biological tissue sampling device according to claim 4, characterized in that: An angle is formed between the inner wall and the outer wall of the cutting edge, and the angle is less than or equal to 45 degrees.

6. The sampling blade of the biological tissue sampling device according to claim 5, characterized in that: The angle is less than or equal to 30 degrees.

7. A sampling assembly of a biological tissue sampling device, characterized in that: comprising a sample collection tube and a sampling cutter head according to any one of claims 1 to 6, which are independently arranged; A second through hole is formed in the sample collection tube, and the diameter of at least a portion of the second through hole is equal to the outer diameter of the cutting piece, so that the cutting piece can seal one end of the sample collection tube after extending into the second through hole, and the other end of the sample collection tube is detachably connected to a tube cap.

8. The sampling assembly of the biological tissue sampling device according to claim 7, characterized in that: The second through hole includes a first section and a second section that are connected, wherein the diameter of the first section is equal to the outer diameter of the cutting member, the diameter of the second section is larger than the diameter of the first section, and the length of the cutting member is larger than the length of the first section, so that after the cutting member passes through the first section, a portion of the cutting member is located in the second section.

9. The sampling assembly of the biological tissue sampling device according to claim 7 or 8, characterized in that: One end of the sample collection tube is detachably connected to a tube cap to seal the opening of the second through hole away from the first section. A sealing member is provided in the first section of the second through hole to cooperate with the tube cap to form a sealed space in the second through hole.

10. The sampling assembly of the biological tissue sampling device according to claim 9, characterized in that: The sealing member is a consumable member. When the cutting member extends into the first section, the sealing member is damaged under the action of the cutting member, so that part of the cutting member can extend into the second section.

11. The sampling assembly of the biological tissue sampling device according to claim 9, characterized in that: The sealing member is an elastic member. When the cutting member extends into the first section, the cutting member pushes the sealing member into the second section, so that part of the cutting member can extend into the second section.

12. A biological tissue sampling device, characterized in that: A sampling assembly comprising a sampler and any one of claims 7 to 11; Wherein, the sampling blade and the sample collection tube are both detachably connected to the sampler, and during the sampling process, the sampler includes a first driving state and a second driving state; Wherein, in the first driving state, the sampler drives the sampling cutter head to move toward the sample collection tube. After the sampling cutter head obtains the biological tissue sample, the sampling cutter head is connected to the sample collection tube so that the obtained biological tissue sample is in the sample collection tube, and one end of the sample collection tube is blocked by the cutting member of the sampling cutter head; In the second driving state, the sampler drives the sampling cutter head to move toward one side, so that the next cutting member is connected to the sampler.

13. The biological tissue sampling device according to claim 12, characterized in that: In the first driving state, after the cutting member of the sampling cutter head is driven to extend into the sample collection tube, the plugging member is driven to move toward the sample collection tube to push the biological tissue sample in the cutting member into the sample collection tube.

14. The biological tissue sampling device according to claim 13, characterized in that: The sampler includes a first driving member and a first pushing member, wherein the first pushing member includes a first-stage pushing rod and a second-stage pushing rod, and the first-stage pushing rod is sleeved on the outside of the second-stage pushing rod. When the sampler is in the first driving state, the first driving member drives the first-stage pushing rod and the second-stage pushing rod to move synchronously to push the cutting member into the sample collection tube. When the first-stage pushing rod moves a preset distance, the first driving member drives the second-stage pushing rod to continue moving, driving the embolic member to move toward the sample collection tube, so as to push the biological tissue sample in the cutting member into the sample collection tube.

15. The biological tissue sampling device according to claim 12, characterized in that: The sampler includes a second driving member and a second pushing member. When the sampler is in the second driving state, the second driving member drives the second pushing member to move, so as to drive the sampling cutter head to move toward one side, so that the next cutting member is connected to the sampler.

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