Anti-aging nutrition supporting agent and application

Abstract

The invention provides an anti-aging nutrition supporting agent and application thereof. The core active ingredients of the nutrition supporting agent comprise levocarnitine, D-ribose, coenzyme Q10, glycine, taurine and ascorbic acid. All the components of the nutrition supporting agent have a synergistic effect, so that the movement balance, coordination, endurance and cognitive functions of old people can be remarkably improved.

Description

Technical Field

[0001] The present invention belongs to the field of nutrition and health, and in particular relates to an anti-aging nutritional support agent and its use. Background Art

[0002] With the accelerating global aging process, the decline in motor function (such as balance, coordination, and endurance) and cognitive function in the elderly has become a key issue affecting their quality of life. Studies have shown that the decline in motor function is closely related to energy metabolism disorders, muscle loss, mitochondrial dysfunction, and oxidative stress, while the decline in cognitive function is associated with insufficient brain energy supply, neurotransmitter imbalance, and neuronal damage. To address these issues, the development of a nutritional support agent based on a multi-target nutritional intervention strategy has important clinical significance and social value.

[0003] Patent application publication number CN118178383A discloses an anti-aging composition and its application, as well as an anti-aging capsule and its application. The present invention provides an anti-aging composition comprising the following components by weight: 20-2000 parts of calcium α-ketoglutarate, 20-100 parts of quercetin, 20-2000 parts of trans-resveratrol, 20-100 parts of calendulin, and 0.02-1.8 parts of spermidine. The composition of this invention targets the 12 major causes of aging, with multi-target synergistic effects. It can safely and effectively reverse aging, enhance physiological function, reduce the risk of chronic diseases, and improve quality of life. The composition is safe and reliable, made from carefully selected natural food ingredients, and has no side effects with long-term use. The oral dosage form is convenient to take, easy to adhere to, and can expand its application methods. The invention does not disclose whether it has the function of improving motor coordination, balance, or endurance.

[0004] The patent with publication number CN110664824A discloses a nutritional support agent with enhanced cardiac function, the active ingredients of which include L-carnitine, D-ribose, and coenzyme Q10, with the amounts of L-carnitine, D-ribose, and coenzyme Q10 being 10-25 parts, 20-60 parts, and 0.5-2 parts, respectively. The nutritional support agent provided by the present invention organically integrates and comprehensively supplements various important myocardial energy metabolism substrates and intermediates, maintains ATPase activity, increases ATP metabolic synthesis substrates, increases ATP synthesis, enhances cardiac energy production, improves cardiac function, and actively improves vascular endothelial function, comprehensively promoting the heart to restore healthy vitality; it can also indirectly increase NO biosynthesis, increase energy substrate metabolism for the heart, reduce cardiac energy consumption, improve vascular endothelial function, maintain vascular relaxation; prevent platelets from adhering to and aggregating in the vascular endothelium; inhibit vascular smooth muscle proliferation; prevent leukocytes from adhering to the vascular endothelium, and protect the vascular endothelium from harm. Although the nutritional support agent of this invention has the function of enhancing cardiac function, it does not disclose the anti-aging function. Summary of the Invention

[0005] The present invention provides an anti-aging nutritional support agent and its use. The core active ingredients of the nutritional support agent include L-carnitine, D-ribose, coenzyme Q10, glycine, taurine, and ascorbic acid. These ingredients work synergistically to significantly improve motor balance, coordination, endurance, and cognitive function in the elderly.

[0006] L-Carnitine promotes fatty acid metabolism, enhances muscle energy supply, and improves endurance and athletic ability.

[0007] D-ribose, as a precursor for ATP synthesis, quickly replenishes cellular energy, relieves fatigue, and improves athletic performance.

[0008] As a key component of the mitochondrial electron transport chain, Coenzyme Q10 improves cellular energy metabolism, reduces oxidative stress, and protects nerve and muscle cells.

[0009] Taurine has antioxidant, anti-inflammatory and neuroprotective effects, while regulating calcium ion balance, enhancing muscle contraction function and nerve conduction efficiency.

[0010] The technical solutions provided by the present invention are as follows:

[0011] A novel use of a nutritional support agent for enhancing cardiac function in anti-aging, wherein the nutritional support agent comprises L-carnitine, D-ribose, coenzyme Q10, glycine, taurine and ascorbic acid.

[0012] Preferably, the nutritional support agent comprises 1-6 parts of L-carnitine, 10-30 parts of D-ribose, 0.1-1 parts of coenzyme Q10, 5-15 parts of potassium glycinate, 3-10 parts of taurine, and 1-5 parts of ascorbic acid.

[0013] Preferably, the nutritional support agent further comprises auxiliary materials.

[0014] Preferably, the auxiliary materials include 10-30 parts of oligofructose, 1-5 parts of spices, 0.01-0.1 parts of sweeteners, 20-40 parts of crystalline cellulose, 1-5 parts of sucrose fatty acid esters, and 1-5 parts of wax-αD-6.

[0015] Preferably, the nutritional support agent is used to promote the improvement of motor coordination, balance ability, endurance and cognitive function of mammals.

[0016] Preferably, mammals include humans, non-human primates, and mice.

[0017] Preferably, the use is to promote motor coordination, balance, endurance and cognitive function improvement in aging mice.

[0018] The present invention also provides use of the nutritional support agent in the preparation of anti-aging drugs.

[0019] This invention utilizes a scientifically formulated combination of highly effective active ingredients to target multiple mechanisms of energy metabolism disorders, oxidative stress, and neuromuscular decline in the elderly. This nutritional support agent is highly effective, safe, and easily absorbed, significantly enhancing motor function and cognitive abilities in the elderly, providing a novel solution for improving their quality of life. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.

[0021] Figure 1 The motor balance ability of old mice and young mice in the preferred embodiment of the present invention;

[0022] Figure 2 The preferred embodiment of the present invention is the exercise endurance of old mice and young mice;

[0023] Figure 3 The cognitive abilities of old and young mice in the preferred embodiment of the present invention;

[0024] Figure 4 The motor balance ability of old mice and young mice after 3 weeks of administration in the preferred embodiment of the present invention;

[0025] Figure 5 This is the exercise endurance of old and young mice after 3 weeks of administration in a preferred embodiment of the present invention;

[0026] Figure 6 This is a preferred embodiment of the present invention, showing the cognitive abilities of old and young mice after 3 weeks of administration. DETAILED DESCRIPTION

[0027] Unless otherwise specified, the methods used in the following examples are all conventional methods.

[0028] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0029] To facilitate understanding of the present invention, the present invention will be described more fully below. The present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the present disclosure more thorough and comprehensive.

[0030] Example 1

[0031] A nutritional support agent, whose active ingredients (main ingredients) are prepared from the following ingredients in parts by weight: 5 parts of L-carnitine, 20 parts of D-ribose, 1 part of coenzyme Q10, 10 parts of magnesium glycinate, 5 parts of taurine, and 1 part of ascorbic acid.

[0032] In this embodiment, 20 parts of oligofructose, 2 parts of spices, 0.1 parts of sweetener, 33.9 parts of crystalline cellulose, 1 part of sucrose fatty acid ester, and 1 part of wax-αD-6 are used. Other types of auxiliary materials can also be selected, and the amount used is the conventional amount in the art.

[0033] The preparation method of the nutritional support agent in this embodiment is as follows:

[0034] 1. Grind the main ingredients and auxiliary materials into 80 mesh;

[0035] 2. Place the above raw materials and auxiliary materials in a mixing tank and mix thoroughly;

[0036] 3. Sterilize all raw and auxiliary materials with ultraviolet light for 30 seconds, then repackage them into 5mg / bag, and clean and disinfect the outer packaging with 75% alcohol.

[0037] Example 2

[0038] A nutritional support agent, wherein the active ingredients (main ingredients) are prepared from the following ingredients in parts by weight: 4.55 parts of L-carnitine, 20 parts of D-ribose, 1 part of coenzyme Q10, 9.1 parts of magnesium glycinate, 5 parts of taurine, and 1 part of ascorbic acid.

[0039] Auxiliary materials: 20 parts of oligofructose, 2 parts of spices, 0.06 parts of sweetener, 35.29 parts of crystalline cellulose, 1 part of sucrose fatty acid ester, and 1 part of wax-αD-6.

[0040] Example 3

[0041] A nutritional support agent, whose active ingredients (main ingredients) are prepared from the following ingredients in parts by weight: 3 parts of L-carnitine, 30 parts of D-ribose, 1 part of coenzyme Q10, 8 parts of magnesium glycinate, 5 parts of taurine, and 1 part of ascorbic acid.

[0042] Example 4

[0043] A nutritional support agent, whose active ingredients (main ingredients) are prepared from the following ingredients in parts by weight: 2 parts of L-carnitine, 20 parts of D-ribose, 0.8 parts of coenzyme Q10, 5 parts of magnesium glycinate, 5 parts of taurine, and 1 part of ascorbic acid.

[0044] Example 5

[0045] A nutritional support agent, wherein the active ingredients (main ingredients) are prepared from the following ingredients in parts by weight: 4.55 parts of L-carnitine, 20 parts of D-ribose, 1 part of coenzyme Q10, 9.1 parts of magnesium glycinate, and 5 parts of taurine.

[0046] Example 6

[0047] A nutritional support agent, wherein the active ingredients (main ingredients) are prepared from the following ingredients in parts by weight: 4.55 parts of L-carnitine, 20 parts of D-ribose, 1 part of coenzyme Q10, 9.1 parts of magnesium glycinate, and 5 parts of taurine.

[0048] Example 7

[0049] A nutritional support agent, whose active ingredients (main ingredients) are prepared from the following ingredients in parts by weight: 4.55 parts of L-carnitine, 20 parts of D-ribose, 1 part of coenzyme Q10, 5 parts of taurine, and 1 part of ascorbic acid.

[0050] Example 8

[0051] The nutritional support agent (5 mg / bag) prepared in Example 2 was administered to experimental animals to verify its function.

[0052] Aged mice (18 months) and young mice (2 months) were purchased from Sibeifu (Beijing) Biotechnology Co., Ltd. They were housed in a clean environment with a normal day and night cycle and free access to food.

[0053] Each bag of the nutritional support agent was dissolved in 50 mL of 0.5% sodium carboxymethylcellulose (CMC-Na) as the solvent, and the experimental group was given 0.2 mL each time daily.

[0054] Before the experiment began, the motor coordination and balance ability (balance beam), motor coordination and endurance (rotarod) and cognitive ability (novel object recognition) of the old and young mice were tested.

[0055] Balance beam: The balance beam device consists of a wooden beam 1 cm wide and 120 cm long suspended 50 cm above the ground and a dark box with a length, width and height of 25 cm. Due to the dark tendency of mice, when mice are placed on one side of the beam, they will run to the dark box at the other end. The time it takes for mice to cross the beam is recorded. The time it takes for older mice to cross the beam is significantly longer ( Figure 1 ).

[0056] Rotarod: To avoid falling, mice need to run in the opposite direction of the rotating rod, which requires coordinated movement of all four limbs. As the speed increases, the mice need to continuously increase their running speed. The continuous running time of mice on the rotating rod at each time point was recorded in seconds. The running time of old mice on the rotating rod was significantly shortened ( Figure 2 ).

[0057] New object recognition: 2 hours before the start of the experiment, the mice were transferred to the behavioral experiment room to adapt to the test environment. At the beginning of training, two identical objects A and B were placed at the left and right ends of one side of the field. The mice were placed in the field with their backs facing the two objects, and the distance between the tip of the mouse's nose and the two objects must be the same. Start the recording program immediately after the mouse is placed in, and record the contact between the mouse and the two objects within 10 minutes, including the number of times the nose or mouth touches the object and the time spent exploring within 2-3 cm from the object (forepaws resting on the object, nose sniffing the object, licking the object, etc. are all exploratory behaviors). After 10 minutes, immediately put the mouse back into the original cage and test it again 12 hours later (during this period, the mouse remained in the test room). When testing again, object B in the field was replaced with object C, and the precautions were the same as the first test. Start the recording program after the mouse is placed in the field, and observe the same indicators as above. The cognitive index of elderly mice decreased significantly ( Figure 3 ).

[0058] Three weeks after the drug was administered, the elderly mice were again tested on the balance beam, rotating rod, and novel object recognition test. Three weeks after the drug was administered, the motor coordination and balance abilities of the elderly mice were significantly improved ( Figure 4 ), sports coordination and endurance are significantly improved ( Figure 5 ), cognitive ability was significantly improved ( Figure 6 ). In the experimental result graph, * indicates that the significance is less than 0.05, ** indicates that the significance is less than 0.01, and *** indicates that the significance is less than 0.001.

[0059] In summary, the nutritional support agent provided by the present invention can promote the significant improvement of motor coordination and balance ability, motor coordination and endurance, and cognitive ability of elderly mice.

[0060] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. An anti-aging nutritional support agent, characterized in that: The nutritional support agent includes L-carnitine, D-ribose, coenzyme Q10, glycine, taurine and ascorbic acid.

2. The nutritional support agent according to claim 1, characterized in that The nutritional support agent comprises 1-6 parts of L-carnitine, 10-30 parts of D-ribose, 0.1-1 parts of coenzyme Q10, 5-15 parts of potassium glycinate, 3-10 parts of taurine and 1-5 parts of ascorbic acid.

3. The nutritional support agent according to claim 2, characterized in that The nutritional support agent also includes auxiliary materials.

4. The nutritional support agent according to claim 3, characterized in that The auxiliary materials include 10-30 parts of oligofructose, 1-5 parts of spices, 0.01-0.1 parts of sweeteners, 20-40 parts of crystalline cellulose, 1-5 parts of sucrose fatty acid esters, and 1-5 parts of wax-αD-6.

5. Use of the nutritional support agent according to claim 1 in promoting the improvement of motor coordination, balance ability, endurance and cognitive function in mammals.

6. The use according to claim 5, characterized in that The mammals include humans, non-human primates, and mice.

7. The use according to claim 6, characterized in that The use is to promote the improvement of motor coordination, balance ability, endurance and cognitive function of aging mice.

8. Use of the nutritional support agent according to claim 7 in the preparation of anti-aging drugs.

Images