Instant medicinal empty capsule and preparation method thereof

Abstract

The invention relates to the technical field of medicinal auxiliary materials, in particular to an instant medicinal empty capsule and a preparation method thereof. The instant medicinal empty capsule is prepared from the following raw materials in percentage by mass: 35 to 55 percent of hydroxypropyl methyl cellulose-starch complex, 1 to 2 percent of trehalose, 1 to 2 percent of surfactant, 4 to 8 percent of gel and the balance of water, and plasma activated starch is contained in the hydroxypropyl methyl cellulose-starch complex. According to the instant medicinal empty capsule, the hydroxypropyl cellulose-starch complex is used as a main raw material, trehalose, the surfactant and the gel are matched, and the instant medicinal empty capsule is prepared by adopting a high-temperature mixing and high-temperature drying process; the oral medicine can play a better curative effect, the safety of the oral medicine is improved, and meanwhile, the oral medicine has excellent dissolving property and antibacterial property.

Description

Technical Field

[0001] The present application relates to the technical field of pharmaceutical excipients, and more specifically, to a fast-dissolving medicinal hollow capsule and a preparation method thereof. Background Art

[0002] Medicinal hollow capsules are widely used in the pharmaceutical market and are a crucial component of drug packaging. They play a crucial role in improving drug stability, facilitating targeted drug release, and masking unpleasant drug tastes. Gelatin capsules are one of the most commonly used medicinal hollow capsules. They are typically made from gelatin, glycerin, and water, with gelatin being the primary ingredient. Derived from animal skin and bones, they are a natural protein with excellent plasticity and processability.

[0003] However, with the frequent occurrence of foot-and-mouth disease, mad cow disease, and avian influenza in recent years, people have increasingly questioned the safety of gelatin. Moreover, gelatin capsules dissolve extremely slowly in gastric juice, usually taking 15-30 minutes. Therefore, gelatin capsules still have certain shortcomings in scenarios where emergency treatment is required or drugs need to take effect quickly. Summary of the Invention

[0004] In order to improve the defects of gelatin capsules such as insufficient safety and poor solubility, the present application provides a fast-dissolving medicinal hollow capsule and a preparation method thereof.

[0005] In a first aspect, the present application provides a fast-dissolving medicinal hollow capsule, which adopts the following technical solution: A fast-dissolving medicinal hollow capsule comprises the following raw materials in percentage by mass: 35-55% of a hydroxypropyl methylcellulose-starch complex, 1-2% of trehalose, 1-2% of a surfactant, and 4-8% of a gelling agent, with the remainder being water. The hydroxypropyl methylcellulose-starch complex contains plasma-activated starch.

[0006] The hydroxypropyl methylcellulose-starch complex contains plasma-activated starch. When the starch is activated by plasma, the linear chains and side chains of the starch will be broken to varying degrees, thereby changing the structural characteristics of the starch, making its structure more orderly and obtaining better solubility. Compared with traditional capsules that take 20-30 minutes to dissolve in gastric juice, the fast-dissolving medicinal hollow capsules of the present application can be completely dissolved in only 3-5 minutes, effectively accelerating drug release.

[0007] Although starch acquires excellent solubility after plasma activation, its mechanical strength also deteriorates significantly, resulting in fast dissolution but poor storage of instant pharmaceutical capsules. Hydroxypropyl methylcellulose (HPMC) is a stable molecular structure with excellent film-forming properties that does not affect the filling of hollow capsules. The synergistic effect of trehalose on hydroxypropyl methylcellulose forms a composite network structure in the plasma-activated starch system, effectively compensating for the loss of mechanical strength caused by plasma activation of starch without affecting the solubility of the plasma-activated starch. This allows instant pharmaceutical capsules to dissolve quickly and be easily stored.

[0008] Preferably, the method for preparing the plasma-activated starch comprises the following steps: Deionized water is treated under atmospheric pressure plasma to obtain plasma-activated water; the atmospheric pressure plasma jet treatment time is 1-3 minutes, the power is 700-800W, and the height is 20-30mm; Bake the potato starch at 40-60°C until the moisture content is less than 5%; Plasma-activated water was added to the dried potato starch until the moisture content reached 20-30%, mixed evenly, and placed at room temperature for 10-14 hours, then transferred to an environment of 100-120°C for reaction for 10-14 hours, and finally cooled naturally and washed three times with deionized water, washed with ethanol in sequence, and finally dried and ground to obtain plasma-activated starch.

[0009] Preferably, the hydroxypropyl methylcellulose-starch complex contains tea polyphenol-chitosan-based hydroxypropyl methylcellulose.

[0010] Starch acquires extremely good water absorption properties after plasma activation, but it also makes it more susceptible to mildew. In this application, a tea polyphenol-chitosan complex is loaded on hydroxypropyl methylcellulose to inhibit bacterial growth and reproduction. When tea polyphenols and chitosan are compounded, they will have a broader antibacterial spectrum and a wider antibacterial coverage, achieving a synergistic effect.

[0011] Specifically, the antibacterial mechanism of chitosan lies in the fact that the chitosan molecular chain has a large number of amino groups, which carry a positive charge in an acidic environment, while the bacterial cell wall is usually negatively charged. The two are attracted to each other through electrostatic interaction. Chitosan adheres to the bacterial surface and then penetrates the cell membrane, destroying the integrity of the cell membrane, causing the leakage of intracellular substances and the death of the bacteria. For Gram-positive bacteria, the cationic charge in chitosan non-covalently bonds with the teichoic acid in the peptidoglycan layer, causing the peptidoglycan in the cell wall to be hydrolyzed, resulting in the leakage of intracellular components. For Gram-negative bacteria, chitosan may interact electrostatically with the anionic lipopolysaccharide in the outer membrane.

[0012] In addition, chitosan can also interact with biomacromolecules such as enzymes, proteins, and nucleic acids within bacterial cells, interfering with their normal functions and thus inhibiting bacterial growth and reproduction. For example, chitosan can penetrate into cells, bind to nucleic acid information, affect the cell's DNA expression, block bacterial metabolic processes, and inhibit its growth and reproduction.

[0013] The antibacterial mechanism of tea polyphenols lies in their ability to penetrate microbial cell membranes and disrupt their integrity. For example, tea polyphenols can gradually destroy the integrity of the Pseudomonas cell wall, allowing alkaline phosphatase to leak out, which in turn damages the cell membrane and forms channels in the cell membrane, accelerating the leakage of contents and disrupting bacterial metabolism, thus exerting an antibacterial effect.

[0014] In addition, tea polyphenols can inhibit the activity of some key enzymes in microorganisms, interfering with their normal metabolic processes and thus inhibiting their growth. For example, the phenolic hydroxyl groups in tea polyphenols can combine with the amino or carboxyl groups in the enzyme proteins in bacteria, occupying the active center of the enzyme or changing the spatial structure of the enzyme, causing the enzyme to lose its activity, thereby affecting the bacterial metabolism, respiration and other physiological processes.

[0015] Preferably, the tea polyphenol-chitosan-based hydroxypropyl methylcellulose comprises the following raw materials in parts by mass: 1-4 parts of hydroxypropyl methylcellulose, 1-4 parts of chitosan, 1-3 parts of glycerol and 0.2-0.6 parts of tea polyphenol.

[0016] Preferably, the preparation method of the tea polyphenol-chitosan-based hydroxypropyl methylcellulose is as follows: 1-4g chitosan and 1-4g hydroxypropyl methylcellulose are dissolved in 200ml of 1% acetic acid solution, 1-3g glycerol is added after stirring to dissolve, and the mixture is stirred at room temperature for 2-6h, and finally 0.2-0.6g tea polyphenol is added, and the mixture is mixed and stirred to obtain tea polyphenol-chitosan-based hydroxypropyl methylcellulose.

[0017] Preferably, the mass ratio of the tea polyphenol-chitosan-based hydroxypropyl methylcellulose to the plasma-active starch is (5-7): (2-3).

[0018] When the mass ratio of tea polyphenol-chitosan-based hydroxypropyl methylcellulose to plasma-active starch is (5-7): (2-3), the prepared fast-dissolving medicinal hollow capsules will have excellent solubility, storage performance and antibacterial properties.

[0019] Preferably, the surfactant is one of sodium lauryl sulfate and Tween-80.

[0020] Preferably, the gelling agent is one of sodium alginate, agar and carrageenan.

[0021] In a second aspect, the present application provides a method for preparing a fast-dissolving medicinal hollow capsule, which adopts the following technical solution: A method for preparing a quick-dissolving medicinal hollow capsule comprises the following steps: S1. Mixing tea polyphenol-chitosan-based hydroxypropyl methylcellulose and plasma-activated starch at a temperature of 30-40° C. to obtain a hydroxypropyl methylcellulose-starch complex; S2. Add hydroxypropyl methylcellulose-starch complex, trehalose, surfactant and gelling agent to water, continue stirring evenly, and then stand at 30-40° C. for 1-3 hours to obtain capsule preparation solution; S3. The capsule preparation liquid is fed into the capsule production line, and the capsules are dipped in glue, formed, and dried in sequence. The drying temperature is 30-50°C, the relative humidity is 20-30%, and the drying time is 3-4 hours. Finally, the capsules are demoulded and cut to obtain instant medicinal hollow capsules.

[0022] In summary, this application has the following beneficial effects: The fast-dissolving medicinal hollow capsules of the present application are made of hydroxypropyl cellulose-starch complex as the main raw material, combined with trehalose, surfactants and gelling agents, and are produced by high-temperature mixing and high-temperature drying processes. Plant-based raw materials are creatively used instead of animal-based raw materials to make capsules, allowing oral medications to exert better therapeutic effects and improve their safety.

[0023] The hydroxypropyl methylcellulose-starch complex contains plasma-activated starch. When the starch is activated by plasma, the linear chains and side chains of the starch will be broken to varying degrees, thereby changing the structural characteristics of the starch, making its structure more orderly and obtaining better solubility. Compared with traditional capsules that take 20-30 minutes to dissolve in gastric juice, the fast-dissolving medicinal hollow capsules of the present application can be completely dissolved in only 3-5 minutes, effectively accelerating drug release.

[0024] 3. Although starch obtains extremely excellent solubility after plasma activation, at the same time, the mechanical strength of starch will also deteriorate significantly, resulting in fast dissolution of instant medicinal capsules but difficulty in preservation. In this regard, the hydroxypropyl methylcellulose-starch complex also contains hydroxypropyl methylcellulose, and the molecular structure of hydroxypropyl methylcellulose is very stable and has excellent film-forming properties. While not affecting the filling of the hollow capsule, it can also form a composite network structure in the plasma-activated starch system under the synergistic effect of trehalose. While not affecting the solubility of the plasma-activated starch, it also effectively compensates for the loss of mechanical strength caused by the starch plasma activation, achieving the effect of instant dissolution and easy storage of instant medicinal capsules.

[0025] 4. Starch has excellent water absorption properties after plasma activation, but it also makes it more prone to mold. In this application, a tea polyphenol-chitosan complex is loaded on hydroxypropyl methylcellulose. Tea polyphenols have a significant inhibitory effect on both Gram-positive and Gram-negative bacteria, and chitosan hinders gas exchange inside and outside the cell by changing the permeability of the bacterial cell membrane, thereby inhibiting bacterial growth and reproduction. When the two are compounded, they will have a broader antibacterial spectrum, a wider antibacterial coverage, and a synergistic effect. DETAILED DESCRIPTION

[0026] The present application is further described in detail below in conjunction with Examples 1 to 6 and Comparative Examples 1 to 2.

[0027] raw material Potato starch CAS: 9005-25-8; Hydroxypropyl methylcellulose CAS: 9004-65-3; Chitosan (plant source) Xi'an Kangnuo Chemical; Glycerol CAS: 56-81-5; Tea Polyphenols CAS: 84650-60-2; Tween-80 CAS: 9005-65-6; Sodium Alginate CAS: 9005-38-3.

[0028] Example 1 A fast-dissolving medicinal hollow capsule comprises the following raw materials in percentage by mass: 45% hydroxypropyl methylcellulose-starch complex, 1.5% trehalose, 1.5% surfactant (Tween-80), 6% gelling agent (sodium alginate), and the balance is water.

[0029] The preparation method of the instant medicinal hollow capsule comprises the following steps: S1. Mixing tea polyphenol-chitosan-based hydroxypropyl methylcellulose and plasma-activated starch at a temperature of 35° C. to obtain a hydroxypropyl methylcellulose-starch complex; The mass ratio of tea polyphenol-chitosan-based hydroxypropyl methylcellulose to plasma-active starch is 6:2.5.

[0030] S2. Add hydroxypropyl methylcellulose-starch complex, trehalose, surfactant and gelling agent to water, continue stirring evenly, and then stand at 35° C. for 2 hours to obtain capsule preparation solution; S3. The capsule preparation liquid is fed into the capsule production line, and the capsules are dipped in glue, formed, and dried in sequence. The drying temperature is 40°C, the relative humidity is 25%, and the drying time is 4 hours. Finally, the capsules are demoulded and cut to obtain instant medicinal hollow capsules.

[0031] The tea polyphenol-chitosan-based hydroxypropyl methylcellulose includes the following raw materials: 4g hydroxypropyl methylcellulose, 2g chitosan, 2g glycerol and 0.4g tea polyphenol.

[0032] The preparation method of tea polyphenol-chitosan-based hydroxypropyl methylcellulose is as follows: 4g of chitosan and 2g of hydroxypropyl methylcellulose are dissolved in 200ml of 1% acetic acid solution, 2g of glycerol is added after stirring to dissolve, and the mixture is stirred at room temperature for 4h, and finally 0.4g of tea polyphenol is added, and the mixture is mixed and stirred to obtain tea polyphenol-chitosan-based hydroxypropyl methylcellulose.

[0033] The preparation method of plasma activated starch comprises the following steps: (1) Deionized water was treated under atmospheric pressure plasma to obtain plasma-activated water; the atmospheric pressure plasma jet treatment time was 2 min, the power was 750 W, and the height was 24 mm; (2) Dry the potato starch at 50°C until the moisture content is less than 5%; (3) Plasma-activated water was added to the dried potato starch until the moisture content reached 25%. After mixing evenly, the mixture was placed at room temperature for 12 h, and then transferred to a 110 °C environment for reaction for 12 h. Finally, the mixture was naturally cooled and washed three times with deionized water, and then washed with ethanol in sequence, and finally dried and ground to obtain plasma-activated starch.

[0034] Example 2-Example 3 The difference from Example 1 is that the mass ratio of tea polyphenol-chitosan-based hydroxypropyl methylcellulose to plasma-active starch is different, as shown in Table 1.

[0035] Table 1 Mass ratio of each component of hydroxypropyl methylcellulose-starch complex of Example 1 to Example 3 Example 1 Example 2 Example 3 Tea polyphenols-chitosan-based hydroxypropyl methylcellulose 6 5 7 Plasma-activated starch 2.5 3 2 Example 4 The difference from Example 1 is that the tea polyphenol-chitosan-based hydroxypropyl methylcellulose is replaced with the same added amount of chitosan-based hydroxypropyl methylcellulose.

[0036] Chitosan-based hydroxypropyl methylcellulose includes the following raw materials: 4g hydroxypropyl methylcellulose, 2g chitosan, and 2g glycerol.

[0037] The preparation method of chitosan-based hydroxypropyl methylcellulose is as follows: 4g chitosan and 2g hydroxypropyl methylcellulose are dissolved in 200ml 1% acetic acid solution, 2g glycerol is added after stirring to dissolve, and the mixture is stirred at room temperature for 4h to obtain chitosan-based hydroxypropyl methylcellulose.

[0038] Example 5 The difference from Example 1 is that the tea polyphenol-chitosan-based hydroxypropyl methylcellulose is replaced with the same added amount of tea polyphenol-based hydroxypropyl methylcellulose.

[0039] Chitosan-based hydroxypropyl methylcellulose includes the following raw materials: 4g hydroxypropyl methylcellulose, 0.4g tea polyphenols, and 2g glycerol.

[0040] The preparation method of tea polyphenol-based hydroxypropyl methylcellulose is as follows: dissolve 2g of hydroxypropyl methylcellulose in 200ml of 1% acetic acid solution, stir to dissolve, then add 2g of glycerol and 0.4g of tea polyphenols, stir at room temperature for 4h, and obtain tea polyphenol-based hydroxypropyl methylcellulose.

[0041] Example 6 The difference from Example 1 is that the tea polyphenol-chitosan-based hydroxypropyl methylcellulose is replaced with hydroxypropyl methylcellulose in the same amount.

[0042] Comparative Example 1 The difference from Example 1 is that the plasma-activated starch is replaced by potato starch with the same added amount.

[0043] Comparative Example 2 A gelatin capsule, purchased from Shandong Shengtai, GB1373.

[0044] Performance testing Dissolution time test Three samples were taken from each of Examples 1 to 3 and Comparative Examples 1 and 2, and then immersed in artificial gastric fluid (PHYGENE CAS: 59-104 PH1840) in sequence. The time required for complete dissolution was recorded and the average value was taken. The test data are shown in Table 2.

[0045] Table 2 Dissolution time test table of Example 1-Example 3 and Comparative Example 1-Comparative Example 2 Dissolution time Dissolution time Example 1 2′54″ Comparative Example 1 3′36″ Example 2 3′09″ Comparative Example 2 21′20″ Example 3 3′21″ 2. Antibacterial performance test Three samples were taken from each of Examples 1 and 4 to 6, and all samples were placed in a natural environment for 21 days with the humidity maintained at 40% and the temperature at 30°C. The antibacterial properties of all samples were then tested with reference to QB / T2591-2003, and the total colony count was determined with reference to GB / T4789.2-2003. The test data are shown in Table 3.

[0046] Table 3 Antibacterial performance test table of Example 1 and Example 4-Example 6 Antibacterial rate / % Antibacterial rate / % Example 1 99.8% Example 5 97.1% Example 4 98.4% Example 6 92.3% Referring to Examples 1 to 3, Comparative Examples 1 and 2 and in combination with Table 2, it can be seen that the dissolution time of Examples 1 to 3 and Comparative Example 1 is significantly reduced compared to Comparative Example 2. This shows that, compared to gelatin system capsules, the hydroxypropyl methylcellulose-starch system capsules of the present application have a better dissolution effect in gastric juice. In addition, the hydroxypropyl methylcellulose-starch system capsules of the present application also creatively use plant-based raw materials instead of animal-based raw materials to make capsules, allowing oral medications to exert better therapeutic effects and improve their safety.

[0047] With reference to Example 1 and Comparative Example 1 and in combination with Table 2, it can be seen that the dissolution time of Example 1 is further shortened compared with Comparative Example 1, which indicates that plasma activation of starch can further promote the dissolution performance of hollow capsules.

[0048] The reason may be that when starch plasma is activated, the linear chain and side chain of starch will be broken to varying degrees, thereby changing the structural properties of starch, making its structure more orderly, obtaining better solubility properties, and effectively accelerating drug release.

[0049] With reference to Examples 1 to 3 and in combination with Table 2, it can be seen that the dissolution time of Examples 2 to 3 is slightly improved compared with that of Example 1. This indicates that when the mass ratio of tea polyphenol-chitosan-based hydroxypropyl methylcellulose to plasma-active starch is 6:2.5, the prepared fast-dissolving medicinal hollow capsules will have excellent dissolution performance.

[0050] The reason may be that hydroxypropyl methylcellulose has strong water absorption and swelling properties. Therefore, when the tea polyphenol-chitosan-based hydroxypropyl methylcellulose and plasma-active starch adopt the above-mentioned mass ratio, the tea polyphenol-chitosan-based hydroxypropyl methylcellulose and plasma-active starch will have a synergistic effect, thereby obtaining a better dissolution effect.

[0051] In addition, although starch obtains extremely excellent solubility after plasma activation, at the same time, the mechanical strength of starch will also deteriorate significantly, resulting in fast dissolution of instant medicinal capsules but difficulty in preservation. In this regard, the hydroxypropyl methylcellulose-starch complex also contains hydroxypropyl methylcellulose, and the molecular structure of hydroxypropyl methylcellulose is very stable and has excellent film-forming properties. While not affecting the filling of the hollow capsule, it can also form a composite network structure in the plasma-activated starch system under the synergistic effect of trehalose. While not affecting the solubility of the plasma-activated starch, it also effectively compensates for the lack of mechanical strength caused by the starch plasma activation, thereby achieving the effect of instant dissolution and easy storage of instant medicinal capsules.

[0052] Referring to Example 1 and Examples 4-6 and in conjunction with Table 3, it can be seen that the antibacterial rates of Examples 1 and Examples 4-5 are significantly improved compared to Example 6, while the antibacterial rates of Examples 4-5 are relatively lower compared to Example 1. This shows that modifying hydroxypropyl methylcellulose with chitosan or tea polyphenols can effectively improve the antibacterial properties of hollow capsules, and when chitosan and tea polyphenols are used in combination, the prepared hollow capsules have even better antibacterial properties.

[0053] The reason is that starch acquires extremely good water absorption properties after plasma activation, but it also makes it more prone to mildew. In this application, a tea polyphenol-chitosan complex is loaded on hydroxypropyl methylcellulose. Tea polyphenols have a significant inhibitory effect on both Gram-positive and Gram-negative bacteria, and chitosan hinders gas exchange inside and outside the cell by changing the permeability of the bacterial cell membrane, thereby inhibiting bacterial growth and reproduction. When the two are compounded, they will have a broader antibacterial spectrum, a wider antibacterial coverage, and a synergistic effect.

[0054] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A fast-dissolving medicinal hollow capsule, characterized in that: The invention comprises the following raw materials in percentage by mass: 35-55% hydroxypropyl methylcellulose-starch complex, 1-2% trehalose, 1-2% surfactant and 4-8% gelling agent, and the balance is water. The hydroxypropyl methylcellulose-starch complex contains plasma-activated starch.

2. The instant medicinal hollow capsule according to claim 1, characterized in that The preparation method of the plasma activated starch comprises the following steps: (1) Treat deionized water under atmospheric pressure plasma to obtain plasma-activated water; the atmospheric pressure plasma jet treatment time is 1-3 minutes, the power is 700-800W, and the height is 20-30mm; (2) Dry the potato starch at 40-60°C until the moisture content is less than 5%; (3) Plasma-activated water was added to the dried potato starch until the moisture content reached 20-30%, mixed evenly, and placed at room temperature for 10-14 h, then transferred to an environment of 100-120 ° C for reaction for 10-14 h, and finally cooled naturally and washed three times with deionized water, washed with ethanol in sequence, and finally dried and ground to obtain plasma-activated starch.

3. The instant medicinal empty capsule according to claim 1, characterized in that: The hydroxypropyl methylcellulose-starch complex contains tea polyphenol-chitosan-based hydroxypropyl methylcellulose.

4. The instant medicinal empty capsule according to claim 3, characterized in that: The tea polyphenol-chitosan-based hydroxypropyl methylcellulose comprises the following raw materials in parts by mass: 1-4 parts of hydroxypropyl methylcellulose, 1-4 parts of chitosan, 1-3 parts of glycerol and 0.2-0.6 parts of tea polyphenol.

5. The instant medicinal empty capsule according to claim 4, characterized in that The preparation method of the tea polyphenol-chitosan-based hydroxypropyl methylcellulose is as follows: 1-4g of chitosan and 1-4g of hydroxypropyl methylcellulose are dissolved in 200ml of 1% acetic acid solution, 1-3g of glycerol is added after stirring to dissolve, and the mixture is stirred at room temperature for 2-6h. Finally, 0.2-0.6g of tea polyphenol is added, and the mixture is mixed and stirred to obtain tea polyphenol-chitosan-based hydroxypropyl methylcellulose.

6. The instant medicinal empty capsule according to claim 1, characterized in that: The mass ratio of the tea polyphenol-chitosan-based hydroxypropyl methylcellulose to the plasma-active starch is (5-7): (2-3).

7. The instant medicinal empty capsule according to claim 1, characterized in that: The surfactant is one of sodium lauryl sulfate and Tween-80.

8. The instant medicinal empty capsule according to claim 1, characterized in that: The gelling agent is one of sodium alginate, agar and carrageenan.

9. A method for preparing the fast-dissolving medicinal empty capsule according to any one of claims 1 to 8, characterized in that: The following steps are involved: S1. Mixing tea polyphenol-chitosan-based hydroxypropyl methylcellulose and plasma-activated starch at a temperature of 30-40° C. to obtain a hydroxypropyl methylcellulose-starch complex; S2. Add hydroxypropyl methylcellulose-starch complex, trehalose, surfactant and gelling agent to water, continue stirring evenly, and then stand at 30-40° C. for 1-3 hours to obtain capsule preparation solution; S3. The capsule preparation liquid is fed into the capsule production line, and the capsules are dipped in glue, formed, and dried in sequence. The drying temperature is 30-50°C, the relative humidity is 20-30%, and the drying time is 3-4 hours. Finally, the capsules are demoulded and cut to obtain instant medicinal hollow capsules.