Zanthoxylum bungeanum extract, trauma skin repairing ointment and preparation method of trauma skin repairing ointment

Abstract

The invention provides a Chinese prickly ash extract, a wound repair ointment and a preparation method thereof, and belongs to the technical field of Chinese prickly ash extraction. A preparation method of the zanthoxylum bungeanum extract comprises the following steps: providing zanthoxylum bungeanum peel, and crushing; the Chinese prickly ash powder is subjected to supercritical CO2 extraction, the extraction pressure is adjusted to be 15-20 MPa, the extraction temperature is adjusted to be 45-50 DEG C, and the conditions are kept for 25-35 min; the extraction pressure is increased to 30-35 MPa, the extraction temperature is 45-50 DEG C, the conditions are kept for 120-180 min, the pressure is reduced, and residues are obtained for standby application; adding propylene glycol or butanediol into the residues, and carrying out ultrasonic-assisted extraction to obtain a solvent extract; and combining the volatile oil, the extract and the solvent extract, adding pregelatinized starch, uniformly mixing, and sieving to obtain the pepper extract. The zanthoxylum bungeanum extract can promote microcirculation and enhance immunity, contains active ingredients for diminishing inflammation, relieving pain and the like, can quickly repair wounds, and has the effects of whitening, removing wrinkles, removing freckles and the like.

Description

Technical Field

[0001] The invention belongs to the technical field of Zanthoxylum bungeanum extraction, and particularly relates to a Zanthoxylum bungeanum extract, a wound repair ointment and a preparation method thereof. Background Art

[0002] Zanthoxylum bungeanum belongs to the Rutaceae family and is the ripe peel of the Sichuan or green pepper. Zanthoxylum bungeanum has a long history of medicinal use, with numerous records in historical herbal compendiums. The Shennong's Herbal Classic states: "Shu pepper is pungent and warming. It treats coughs and reversed reactions caused by pathogenic qi, warms the middle, removes dead skin and muscle tissue from joints, treats pain caused by cold and dampness, and relieves gas. Long-term use prevents graying of hair and promotes weight loss and longevity." The Dietary Materia Medica states that Zanthoxylum bungeanum "eliminates scars and promotes lactation." The Compendium of Materia Medica states that Zanthoxylum bungeanum "dispels cold and dampness...opens the three burners, warms the spleen and stomach, kills roundworms, and stops diarrhea." The Pharmacopoeia of the People's Republic of China states that Zanthoxylum bungeanum can "warm the middle, relieve pain, kill insects, and relieve itching." The medicinal value of Zanthoxylum bungeanum has long been recognized, and its unique bioactive components have become a hot topic of research in modern medicine.

[0003] Currently, pepper extracts mainly rely on supercritical CO2 extraction or organic solvent extraction methods, but the resulting product has complex components, containing dozens of compounds such as volatile oils, alkaloids, flavonoids, etc., and has problems such as complex active ingredients and impurity interference, making it difficult to meet the needs of precision medicine such as wound repair.

[0004] Skin trauma is primarily caused by damage to the skin caused by external forces or surgery. Current treatments for skin trauma primarily involve using alcohol to remove contaminants from the wound surface, applying hydrogen peroxide or iodine-containing disinfectants, applying Vaseline ointment, and then applying a proper bandage to prevent infection. The dressing is changed every one or two days, and most of the agents used are organic.

[0005] The main drawbacks of this traditional method are: large, deep wounds take a long time to heal, and they often leave uneven scars. During the skin's healing process, it can easily cause skin discomfort, particularly itching during sleep. This can lead to patients unconsciously scratching the wound, causing secondary damage. In addition to the pain and itching, patients are also restricted from sun exposure, and the healing process is slow.

[0006] In view of this, the present invention provides a Zanthoxylum bungeanum extract, a wound repair ointment and a preparation method thereof. Summary of the Invention

[0007] The technical problem to be solved by the present invention is to provide a Zanthoxylum bungeanum extract to enhance the anti-inflammatory and antioxidant effects, which is suitable for wound repair.

[0008] In order to solve the above technical problems, the technical solution adopted by the present invention is: a Zanthoxylum bungeanum extract, the preparation method of which comprises the following steps:

[0009] Step 1: Provide the peel of Sichuan pepper, crush it to obtain Sichuan pepper powder;

[0010] Step 2: Extract the pepper powder with supercritical CO2, with a CO2 flow rate of ≥140m 3 / h, the entrainer is 5% ethanol, first adjust the extraction pressure to 15-20MPa, the extraction temperature to 45-50℃, maintain for 25-35min, and collect the volatile oil; then increase the extraction pressure to 30-35MPa, the extraction temperature to 45-50℃, maintain for 120-180min, reduce the pressure, collect the extract, and the residue is set aside;

[0011] Step 3: Add propylene glycol or butylene glycol to the residue and perform ultrasonic-assisted extraction to obtain a solvent extract;

[0012] Step 4: Combine the volatile oil, extract and solvent extract, add pregelatinized starch, mix well, and sieve to obtain the Zanthoxylum bungeanum extract.

[0013] Optionally, the amount of entrainer used in step 2 is 4-5 mL / g.

[0014] Optionally, in step 3, 25-30 g of propylene glycol or butylene glycol is added per gram of the residue.

[0015] Optionally, the temperature of the ultrasonic-assisted extraction is 45-50° C., and the time is 35-45 minutes.

[0016] Optionally, the ratio of the added mass of the pregelatinized starch to the combined mass of the volatile oil, the extract and the solvent extract is 100:(30-40).

[0017] The present invention also provides a use of the Zanthoxylum bungeanum extract in a wound skin repair ointment to accelerate wound repair, reduce scar formation, and relieve discomfort symptoms.

[0018] The present invention also provides a wound skin repair ointment containing a Zanthoxylum bungeanum extract, wherein the mass percentage of the Zanthoxylum bungeanum extract in the wound skin repair ointment is 0.5-5%.

[0019] Optionally, the wound skin repair ointment comprises the following components in percentage by mass:

[0020]

[0021] Optionally, the wound skin repair ointment comprises the following components in percentage by mass:

[0022]

[0023]

[0024] Optionally, the preparation method of the trauma skin repair ointment includes the following steps: mixing Zanthoxylum bungeanum extract, Centella asiatica extract, Aloe vera extract, Dendrobium candidum extract, ginger extract, Lithospermum officinale extract, Chuanxiong extract, Rehmannia glutinosa extract, green tea extract and borneol, slowly adding the evenly mixed materials to the matrix while stirring, and continuing to stir until uniform after adding to obtain the ointment.

[0025] Optionally, the matrix includes the following components in percentage by weight:

[0026]

[0027] Optionally, the matrix is prepared by the following method:

[0028] Step 1: Mix carbomer, sodium hyaluronate and water evenly to obtain an aqueous phase;

[0029] Step 2: Heat and melt monoglyceride stearate, oil and lanolin, add methyl paraben and mix evenly to obtain an oil phase;

[0030] Step 3: Slowly add the oil phase into the water phase, add Tween-80 under stirring, and mix well to obtain the matrix.

[0031] Compared with the prior art, the present invention has the following beneficial effects:

[0032] Based on the above scheme, the present invention provides a Zanthoxylum bungeanum extract, which specifically obtains a mixture of multiple active ingredients such as volatile oils, ephedrine, flavonoids, polyphenols, etc. by combining segmented supercritical extraction and polar solvent-assisted extraction. Among them, volatile oils and ephedrine mainly enhance the anti-inflammatory effect, while flavonoids and polyphenols mainly enhance the antioxidant effect, so that the Zanthoxylum bungeanum extract can be accurately used for wound repair.

[0033] The present invention first extracts volatile oils and oleoresins through supercritical CO2 segmented extraction. Low-polarity volatile oils, such as limonene and aromatic alcohols, are extracted at an extraction pressure of 15-20 MPa and a temperature of 45-50°C. Larger oleoresin components, such as linalool and phytosterols, are extracted at an extraction pressure of 30-35 MPa and a temperature of 45-50°C for 120-180 minutes. The use of 5% ethanol as an entrainer improves extraction efficiency. Next, using propylene glycol or butylene glycol as a solvent, ultrasonically disrupts the cell walls, releasing active substances such as flavonoids and polyphenols. Residual solvent removal is unnecessary, enhancing skin penetration of the active ingredients. Finally, the extracts are combined and pregelatinized starch is used as a diluent to improve mixing uniformity and storage stability. The resulting Zanthoxylum bungeanum extract exhibits significant anti-inflammatory and antioxidant effects, meeting the needs of wound repair.

[0034] The present invention is based on Zanthoxylum bungeanum extract, and a wound repair ointment is obtained by combining ingredients. The ointment is based on the principle of removing blood stasis and promoting new blood, clearing heat and detoxifying, and promoting blood circulation and unblocking meridians. The ointment is prepared by combining Zanthoxylum bungeanum extract, Centella asiatica extract, Aloe vera extract, Dendrobium officinale extract, Ginger extract, Lithospermum officinale extract, Chuanxiong rhizome extract, Rehmannia glutinosa extract, Green tea extract and Borneol. Among them, Zanthoxylum bungeanum extract is the monarch drug, which is antibacterial and promotes repair; Centella asiatica extract, Lithospermum officinale extract, Dendrobium officinale extract, and Aloe vera extract are the ministerial drugs, which enhance repair, clear blood heat, moisturize and detoxify, and nourish yin and promote tissue regeneration; Chuanxiong rhizome extract, Rehmannia glutinosa extract, and Green tea extract are the adjuvant drugs, which promote blood circulation and unblock meridians, cool blood and nourish yin, and have antioxidant effects; Ginger extract and Borneol are the guiding drugs, ginger warms and unblocks the pores, and borneol carries the drug through the skin to enter the meridians, so that the drug reaches the affected area. Thus, the repair ointment of the present invention can achieve anti-inflammatory, antibacterial, antioxidant and moisturizing functions, while meeting the patient's demand for rapid healing of wound repair and reducing scar formation.

[0035] The present invention uses suitable matrix components as carriers to assist in achieving the needs of rapid wound repair and scar reduction. Among them, carbomer can form a gel matrix to prolong the action time of the active ingredients; sodium hyaluronate has a moisturizing effect, can maintain a moist environment on the wound surface, and promote wound repair; Tween-80 enhances the dispersion of fat-soluble components in the Zanthoxylum bungeanum extract and improves transdermal absorption; monoglycerol stearate, oil and lanolin are combined to form an oily matrix, which provides closed protection for the wound surface, reduces water loss from the wound surface, and reduces oxidation of the active ingredients; methyl parahydroxybenzoate is a preservative, which synergistically inhibits bacteria with the natural antibacterial components in the Zanthoxylum bungeanum extract; the essence can mask the odor of the Zanthoxylum bungeanum extract and improve patient compliance; water is used as a solvent and dispersion medium to adjust the consistency of the ointment and ensure uniform distribution of the various ingredients. DETAILED DESCRIPTION

[0036] In order to better understand the present invention, the content of the present invention is further clearly set forth below in conjunction with the examples, but the protection content of the present invention is not limited to the following examples. In the following description, a large number of specific details are provided in order to provide a more thorough understanding of the present invention. However, it is obvious to those skilled in the art that the present invention can be implemented without one or more of these details.

[0037] Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative work shall fall within the scope of protection of the present invention.

[0038] Unless otherwise specified, all raw materials are derived from commercially available products and do not contain other unspecified components except inevitable impurities.

[0039] In the following embodiments of the present invention, Centella asiatica extract, Aloe vera extract, Dendrobium officinale extract, Ginger extract, Lithospermum officinale extract, Chuanxiong extract, Rehmannia glutinosa extract, and Green Tea extract are all commercially available products. These extracts are all purchased in a 10:1 water-soluble powder form, and all have a particle size of less than or equal to 80 mesh.

[0040] Example 1 : A Zanthoxylum bungeanum extract, the preparation method of which comprises the following steps:

[0041] Step 1: Provide the peel of Zanthoxylum bungeanum and crush it into 80 mesh to obtain Zanthoxylum bungeanum powder;

[0042] Step 2: Extract the pepper powder with supercritical CO2, with a CO2 flow rate of 140m 3 / h, the entrainer is 5% ethanol, the dosage is 4.0mL / g, the extraction pressure is first adjusted to 18MPa, the extraction temperature is 48℃, maintained for 30min, and the volatile oil is collected; then the extraction pressure is increased to 32MPa, the extraction temperature is 48℃, maintained for 150min, the extract is collected under reduced pressure, and the residue is set aside;

[0043] Step 3: Add propylene glycol or butylene glycol to the residue and perform ultrasonic-assisted extraction for 40 minutes to obtain a solvent extract;

[0044] Step 4: Combine the volatile oil, extract and solvent extract, add pregelatinized starch, mix well, and sieve to obtain the Zanthoxylum bungeanum extract.

[0045] In step 3, 28 g of propylene glycol or butylene glycol is added per gram of residue.

[0046] The temperature of ultrasonic-assisted extraction was 48 °C and the power was 200W.

[0047] The ratio of the added mass of pregelatinized starch to the combined mass of volatile oil, extract and solvent extract was 100:35.

[0048] Example 2 : A Zanthoxylum bungeanum extract, the preparation method of which comprises the following steps:

[0049] Step 1: Provide the peel of Zanthoxylum bungeanum and crush it into 70 mesh to obtain Zanthoxylum bungeanum powder;

[0050] Step 2: Extract the pepper powder with supercritical CO2, with a CO2 flow rate of 150m 3 / h, the entrainer is 5% ethanol, the dosage is 4.5mL / g, the extraction pressure is first adjusted to 15MPa, the extraction temperature is 50℃, maintained for 35min, and the volatile oil is collected; then the extraction pressure is increased to 35MPa, the extraction temperature is 45℃, maintained for 180min, the extract is collected under reduced pressure, and the residue is set aside;

[0051] Step 3: Add propylene glycol or butylene glycol to the residue and perform ultrasonic-assisted extraction for 45 minutes to obtain a solvent extract;

[0052] Step 4: Combine the volatile oil, extract and solvent extract, add pregelatinized starch, mix well, and sieve to obtain the Zanthoxylum bungeanum extract.

[0053] In step 3, 30 g of propylene glycol or butylene glycol is added per gram of residue.

[0054] The temperature of ultrasonic-assisted extraction was 45 °C and the power was 200W.

[0055] The ratio of the added mass of pregelatinized starch to the combined mass of volatile oil, extract and solvent extract was 100:30.

[0056] Example 3 : A Zanthoxylum bungeanum extract, the preparation method of which comprises the following steps:

[0057] Step 1: Provide the peel of Zanthoxylum bungeanum and crush it into 90 mesh to obtain Zanthoxylum bungeanum powder;

[0058] Step 2: Extract the pepper powder with supercritical CO2, with a CO2 flow rate of 145m 3 / h, the entrainer is 5% ethanol, the dosage is 5.0mL / g, first adjust the extraction pressure to 20MPa, the extraction temperature to 45℃, maintain for 25min, collect the volatile oil; then increase the extraction pressure to 30MPa, the extraction temperature to 50℃, maintain for 120min, reduce the pressure to collect the extract, and the residue is set aside;

[0059] Step 3: Add propylene glycol or butylene glycol to the residue and perform ultrasonic-assisted extraction for 35 minutes to obtain a solvent extract;

[0060] Step 4: Combine the volatile oil, extract and solvent extract, add pregelatinized starch, mix well, and sieve to obtain the Zanthoxylum bungeanum extract.

[0061] In step 3, 25 g of propylene glycol or butylene glycol is added per gram of residue.

[0062] The temperature of ultrasonic-assisted extraction was 50 °C and the power was 200W.

[0063] The ratio of the added mass of pregelatinized starch to the combined mass of volatile oil, extract and solvent extract was 100:40.

[0064] Example 4 : A wound skin repair ointment, made from the following components in percentage by mass:

[0065]

[0066]

[0067] The preparation method of the above-mentioned trauma skin repair ointment comprises the following steps: mixing Zanthoxylum bungeanum extract, Centella asiatica extract, aloe vera extract, dendrobium extract, ginger extract, lithospermum officinale extract, Chuanxiong extract, Rehmannia glutinosa extract, green tea extract and borneol; slowly adding the evenly mixed materials into the matrix under stirring; and continuing to stir until uniform after the addition is completed to obtain the ointment.

[0068] This Example 4 uses the Zanthoxylum bungeanum extract prepared in Example 1.

[0069] Examples 5-8 : The only difference from Example 4 is that the ratio of the components in the trauma skin repair ointment is as shown in Table 1.

[0070] Table 1: Component ratios of Examples 5-8 (%)

[0071]

[0072]

[0073] Both Examples 5 and 6 use the Zanthoxylum bungeanum extract prepared in Example 2.

[0074] Both Examples 7 and 8 used the Zanthoxylum bungeanum extract prepared in Example 3.

[0075] The components of the matrix are shown in Table 2.

[0076] Table 2 Matrix composition (%)

[0077] Component / mass percentage Example 4 Example 5 Example 6 Example 7 Example 8 Twain-80 0.2 2 1 3 5 Monoglyceride Stearate 0.5 2 2 1 0 grease 0 0.5 2 3 5 Lanolin 3 1 0.5 0 2 Methylparaben 2 4 0.1 3 5 Carbomer 3 5 4 2 0.1 Sodium hyaluronate 4 0.1 5 2 1 essence 0 0.1 0.2 0.3 0 water margin margin margin margin margin

[0078] The preparation method of the above matrix comprises the following steps:

[0079] Step 1: Mix carbomer, sodium hyaluronate and water evenly to obtain an aqueous phase;

[0080] Step 2: Heat monoglyceride stearate, oil and lanolin to 70°C to melt, add methyl paraben and mix well to obtain the oil phase;

[0081] Step 3: Slowly add the oil phase into the water phase, add Tween-80 under stirring conditions of 40°C and 1000 rpm, and mix well to obtain the matrix.

[0082] Comparative Example 1 The only difference from Example 1 is that: step 2 of "first adjusting the extraction pressure to 18 MPa, the extraction temperature to 48° C., maintaining for 30 min, and collecting the volatile oil" is omitted, and the corresponding step 4 omits the volatile oil, and the remaining steps are the same.

[0083] Comparative Example 2: Prepare the Zanthoxylum bungeanum extract with reference to Example 1 of recording in patent document CN1220450C.

[0084] Comparative Example 3 The only difference from Example 1 is that step 3 is omitted and the solvent extract is omitted in the corresponding step 4, and the remaining steps are the same.

[0085] The Zanthoxylum bungeanum extracts prepared in Comparative Examples 1-3 were used to prepare ointments according to Example 4 for efficacy evaluation.

[0086] Efficacy evaluation:

[0087] 1. Experimental Preparation

[0088] Thirty-six SPF SD rats weighing 200-250 g, half male and half female, were selected; a blank control group, comparison group 1, comparison group 2, comparison group 3, experimental group 1 and experimental group 2 were set up, with 6 rats in each group, for a total of 6 groups.

[0089] Adaptive breeding: temperature: 22±2℃, humidity 50%-60%, 12-h light-dark cycle.

[0090] The patients were fasted for 12 hours before surgery and had free access to water.

[0091] 2. Establishment of skin defect model

[0092] 3% sodium pentobarbital was injected intraperitoneally at 40 mg / kg, and the rats were fixed on the operating table after the eyelash reflex disappeared.

[0093] The back hair was shaved to an area of approximately 4 cm × 4 cm, disinfected with iodine, and then deiodinated with alcohol.

[0094] Using an 8mm diameter sterile biopsy punch, apply vertical pressure and rotate it into the deep fascia to create a full-thickness skin defect. Create two wounds symmetrically on each side of the spine, with a spacing of ≥1.5cm. Irrigate the wound with normal saline and blot dry with sterile gauze.

[0095] Blank group: covered only with sterile vaseline gauze; Comparative group 1: applied with 0.1 g / cm2 of the ointment of comparative example 1 2 ; Comparison Group 2: Apply Comparative Example 2 ointment 0.1g / cm 2 ; Comparison Group 3: Apply Comparative Example 3 ointment 0.1g / cm 2 Experimental group 1: Apply ointment of Example 4 at 0.1 g / cm 2 Experimental group 2: Apply ointment of Example 5 at 0.1 g / cm 2 .

[0096] After application, cover with 3M breathable dressing and secure with elastic bandage.

[0097] 3. Postoperative management and observation indicators

[0098] 3.1 Daily care

[0099] Dressings were changed daily, and wound exudation and infection were recorded. Redness, swelling, and suppuration were considered infection and required removal. Butorphanol 0.05 mg / kg was administered subcutaneously within 24 hours after surgery for analgesia.

[0100] 3.2 Wound healing evaluation

[0101] (1) Calculation of healing rate: The wound surface was photographed on the 3rd, 7th, 10th, and 14th days after surgery. The remaining wound area was analyzed using ImageJ software, and the healing rate was calculated according to the following formula:

[0102]

[0103] (2) Scar scoring: On the 14th day, scar color, vascularity, thickness, and flexibility were scored according to the Vancouver Scar Scale, as shown in Table 3.

[0104] Table 3 Vancouver Scar Scale Scoring Criteria

[0105]

[0106] Scoring Method: Each assessment item is assigned a score based on the specific manifestations of the scar. The scores for all four items are summed to obtain a total score. The total score ranges from 0 to 14. A higher score indicates a more severe scar.

[0107] 4. Test results

[0108] 4.1 The healing rates of each group are shown in Table 4.

[0109] Table 4 Healing rate results of each group

[0110]

[0111] Note: Compared with the blank control group, * P<0.05.

[0112] As can be seen from the data in Table 4, the healing rates of the experimental group and the control group were improved compared with the blank control group, but the improvements in experimental group 1 and experimental group 2 were more obvious, indicating that the repair ointment of the present invention can significantly accelerate wound healing by shortening the inflammatory period through anti-inflammatory or angiogenesis-promoting.

[0113] 4.2 The scar scoring results of each group are shown in Table 5.

[0114] Table 5 Scar scoring results of each group

[0115]

[0116] Note: Compared with the blank control group, * P<0.05.

[0117] As can be seen from the data in Table 5, compared with the blank control group, the scars formed after wound healing in the experimental group and the comparison group were improved in color, vascular distribution, thickness and flexibility, but the improvements in experimental group 1 and experimental group 2 were more obvious, indicating that the repair ointment of the present invention improves the wound repair effect through anti-inflammatory, angiogenesis-promoting, antioxidant and other effects, reduces pigment deposition and reduces scar formation.

[0118] It can be seen that the wound repair ointment prepared by the present invention using the Zanthoxylum bungeanum extract extracted by a specific method has a significant effect on wound healing and repair.

[0119] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention and are not limiting. Other modifications or equivalent substitutions made to the technical solution of the present invention by ordinary technicians in this field should be included in the scope of the claims of the present invention as long as they do not depart from the spirit and scope of the technical solution of the present invention.

Claims

1. A Zanthoxylum bungeanum extract, characterized in that: The preparation method comprises the following steps: Step 1: Provide the peel of Sichuan pepper, crush it to obtain Sichuan pepper powder; Step 2: Extract the pepper powder with supercritical CO2, with a CO2 flow rate of ≥140m 3 / h, the entrainer is 5% ethanol, first adjust the extraction pressure to 15-20MPa, the extraction temperature to 45-50℃, maintain for 25-35min, and collect the volatile oil; then increase the extraction pressure to 30-35MPa, the extraction temperature to 45-50℃, maintain for 120-180min, reduce the pressure, collect the extract, and the residue is set aside; Step 3: Add propylene glycol or butylene glycol to the residue and perform ultrasonic-assisted extraction to obtain a solvent extract; Step 4: Combine the volatile oil, extract and solvent extract, add pregelatinized starch, mix well, and sieve to obtain the Zanthoxylum bungeanum extract.

2. The Zanthoxylum bungeanum extract according to claim 1, wherein: The amount of the entrainer in step 2 is 4-5 mL / g.

3. The Zanthoxylum bungeanum extract according to claim 1, wherein: In step 3, 25-30 g of propylene glycol or butylene glycol is added per gram of the residue; The temperature of the ultrasonic-assisted extraction is 45-50° C., and the time is 35-45 minutes.

4. The Zanthoxylum bungeanum extract according to claim 1, wherein: The ratio of the added mass of the pregelatinized starch to the combined mass of the volatile oil, the extract and the solvent extract is 100:(30-40).

5. Use of the Zanthoxylum bungeanum extract according to any one of claims 1 to 4 in a wound skin repair ointment.

6. A wound skin repair ointment, characterized in that: The invention comprises the Zanthoxylum bungeanum extract according to any one of claims 1 to 4, wherein the mass percentage of the Zanthoxylum bungeanum extract in the wound skin repair ointment is 0.5-5%.

7. A wound skin repair ointment as claimed in claim 6, characterized in that: The composition includes the following components in mass percentage:

8. The method for preparing a wound skin repair ointment according to claim 7, wherein: The following steps are involved: Mix Zanthoxylum bungeanum extract, Centella asiatica extract, Aloe vera extract, Dendrobium officinale extract, Ginger extract, Lithospermum officinale extract, Chuanxiong rhizome extract, Rehmannia root extract, Green tea extract and Borneol, slowly add the evenly mixed materials into the matrix while stirring, and continue stirring until evenly mixed after the addition is completed to obtain an ointment.

9. The method for preparing a wound skin repair ointment according to claim 7, wherein: The matrix includes the following components in percentage by weight:

10. The method for preparing a wound skin repair ointment according to claim 9, wherein: The matrix is prepared by the following method: Step 1: Mix carbomer, sodium hyaluronate and water evenly to obtain an aqueous phase; Step 2: Heat and melt monoglyceride stearate, oil and lanolin, add methyl paraben and mix evenly to obtain an oil phase; Step 3: Slowly add the oil phase into the water phase, add Tween-80 under stirring, and mix well to obtain the matrix.

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