Weixuekang granules and preparation method thereof

Abstract

The invention belongs to the technical field of medicines, and particularly relates to Weixuekang granules and a preparation method thereof. The preparation method of the Weixuekang granules comprises the following steps: (1) weighing prescription raw materials; (2) extracting volatile oil from fructus amomi and half amount of pericarpium citri reticulatae, and collecting medicine residues; mixing medicine residues with the remaining dried tangerine or orange peel and the remaining six medicines, decocting twice, and respectively filtering; respectively concentrating the filtrates decocted twice, mixing, and concentrating to obtain clear paste; and (3) adding ferrous sulfate into the clear paste, adding auxiliary materials, and granulating to obtain the Weixuekang granules. The extracting solution is directly concentrated, the relative density of the clear paste is adjusted, energy conservation and emission reduction are facilitated, the production efficiency is improved, meanwhile, specific auxiliary materials are added, it can be guaranteed that the stability, dissolution or release behavior of the preparation medicine is not affected, the absorption and utilization of the medicine are not obviously affected, and the method is suitable for large-scale popularization and application. And obvious changes of safety and effectiveness cannot be caused.

Description

Technical Field

[0001] The present invention belongs to the field of medical technology, and in particular relates to Weixuekang granules and a preparation method thereof. Background Art

[0002] Weixuekang is a Chinese and Western medicinal compound made from nine ingredients: Codonopsis pilosula, Rehmannia root, black beans, Chinese yam, dried tangerine peel, Amomum villosum, Polygonum multiflorum, ferrous sulfate, and hawthorn. It tonifies the kidneys and spleen, replenishes blood and nourishes yin. It is clinically indicated for patients with spleen and kidney deficiency, deficiency of essence and blood, sallow complexion, dizziness, tinnitus, weakness in the waist and knees, fatigue, emaciation, nutritional anemia, and iron deficiency anemia.

[0003] The traditional preparation method of Weixuekang granules is as follows: the above nine ingredients, except ferrous sulfate, and the volatile oil of Amomum villosum and half of the tangerine peel are extracted by steam distillation for 3 hours and set aside; the medicinal residues and the remaining tangerine peel and the other six ingredients, including Codonopsis pilosula, are decocted twice with 6 times the amount of water, each time for 2 hours, filtered, the filtrate is combined and concentrated, ethanol is added to make the alcohol content reach 60%, and the mixture is allowed to stand for 12 hours. The supernatant is taken, the ethanol is recovered, and the mixture is cooled to room temperature, filtered, and the filtrate is concentrated; ferrous sulfate is added, and the mixture is thoroughly stirred and mixed, and an appropriate amount of sucrose powder and dextrin are added and mixed to form granules; the mixture is dried, the granules are sprayed with volatile oil, sealed for 30 minutes, and 1000g is made and packaged.

[0004] During the practical production process, it was found that the existing method for preparing Weixuekang granules has the following problems: (1) The filtrates obtained from the two decoctions are combined and concentrated. During the concentration, the filtrate from the second decoction must be prepared and combined with the filtrate from the first decoction before concentration can begin. This takes a long time to produce, and the temperature of the filtrate obtained from the first decoction decreases during the waiting process, which requires more energy to be consumed during the subsequent concentration, which is not conducive to energy conservation and emission reduction. (2) After alcohol precipitation, the supernatant is taken to recover ethanol. The concentrated clear paste is too viscous in production and easily adheres to the pipeline, making it difficult to discharge the material, resulting in material waste, difficult to clean the equipment, and not conducive to the mixing of materials in the subsequent granulation step. (3) The auxiliary materials used are sucrose and dextrin, with the ratio of sucrose to dextrin being 3:1. The large amount of sucrose is not conducive to patients with high blood sugar, diabetes, obesity, etc. who are not suitable for sugar consumption. Summary of the Invention

[0005] In view of the above problems, the purpose of the present invention is to provide a Weixuekang granule and a preparation method thereof.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] A method for preparing Weixuekang granules comprises the following steps:

[0008] (1) Weigh the following ingredients: Codonopsis pilosula, Rehmannia root, black beans, Chinese yam, dried tangerine peel, Amomum villosum, Polygonum multiflorum, ferrous sulfate, and hawthorn;

[0009] (2) extracting volatile oil from Amomum villosum and half of dried tangerine peel by steam distillation, and collecting the residue; mixing the residue with the remaining dried tangerine peel, Codonopsis pilosula, Rehmannia root, black beans, Chinese yam, Polygonum multiflorum, and Crataegus pinnatifida, decocting twice, and filtering each; concentrating the filtrates of the two decoctions, mixing them, adding a solvent, standing, taking the supernatant, cooling to room temperature, filtering, and concentrating the filtrate to obtain a clear paste;

[0010] (3) Add ferrous sulfate to the clear paste, stir and mix, add stevioside, filler, and diluent, mix and mix, wet granulate, dry after wet granulation, spray volatile oil, mix and mix to obtain Weixuekang granules.

[0011] Preferably, the filler is maltodextrin and microcrystalline cellulose in a mass ratio of (2-3):1.

[0012] Preferably, the filler is maltodextrin and microcrystalline cellulose in a mass ratio of 2:1.

[0013] Preferably, the diluent is dextrin.

[0014] Preferably, the prescription raw materials are weighed according to the following mass parts: 100-200 parts of Codonopsis pilosula, 100-200 parts of Rehmannia root, 100-200 parts of black beans, 200-300 parts of yam, 200-300 parts of dried tangerine peel, 10-100 parts of Amomum villosum, 100-200 parts of Polygonum multiflorum, 10-50 parts of ferrous sulfate, and 50-150 parts of hawthorn.

[0015] Preferably, the prescription raw materials are weighed according to the following mass parts: 120 parts of Codonopsis pilosula, 160 parts of Rehmannia root, 160 parts of black beans, 240 parts of yam, 240 parts of dried tangerine peel, 20 parts of Amomum villosum, 138 parts of Polygonum multiflorum, 20 parts of ferrous sulfate, and 120 parts of hawthorn.

[0016] Preferably, the time for extracting the volatile oil by steam distillation in step (2) is 2-4 hours.

[0017] Preferably, the decoction is performed twice in step (2), each time for 1-3 hours.

[0018] Preferably, in step (2), the filtrates from the two decoctions are concentrated at 55-60° C. to a relative density of 1.10-1.15.

[0019] Preferably, the filtrate is concentrated at 55-60° C. to a relative density of 1.25-1.30 to obtain a clear paste.

[0020] Preferably, the drying method in step (3) is to use a vacuum suction horizontal boiling dryer for drying.

[0021] Preferably, the drying conditions are: bed temperature 70-75°C, and drying time 20-40 minutes per bed.

[0022] It should be noted that the steam distillation method used in the present invention is a conventional method in the art. The steam distillation method refers to an extraction method in which plant materials containing volatile components are co-distilled with water, the volatile components are distilled out together with the water vapor, and the volatile components are separated by condensation.

[0023] The second aspect of the present invention provides Weixuekang granules obtained by the preparation method.

[0024] Codonopsis pilosula is the dried root of Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula Nannf. var. modesta (Nannf.) LTShen, or Codonopsis tangshen Oliv. (all plants of the Campanulaceae family). It is harvested in autumn, washed, and sun-dried. The standard for Codonopsis pilosula is included in Part 1 of the 2020 edition of the Chinese Pharmacopoeia.

[0025] Rehmannia glutinosa is a processed product of raw Rehmannia glutinosa. The standard for Rehmannia glutinosa is included in the 2020 edition of the Chinese Pharmacopoeia.

[0026] Black beans are the dried, mature seeds of Glycine max (L.) Merr. (Leguminosae). The mature fruits are harvested in autumn, sun-dried, the seeds removed, and impurities removed. The standard for black beans as a medicinal material is included in Part 1 of the 2020 edition of the Chinese Pharmacopoeia.

[0027] Chinese yam is the dried rhizome of Dioscorea opposita Thunb., a plant of the Dioscoreaceae family. It is dug up in winter after the stems and leaves wither. The root is cut off, washed, and the outer skin and fibrous roots removed. This is commonly known as "hairy yam." Alternatively, the skin is removed and thick slices are cut while fresh, dried, and called "yam slices." Alternatively, plump, straight dried yams are selected, placed in clean water, soaked until the core is dry, and then steamed thoroughly. The ends are trimmed, rolled into a cylindrical shape using a wooden board, sun-dried, and polished. This is commonly known as "glossy yam." The standard for Chinese yam is included in Part 1 of the 2020 edition of the Chinese Pharmacopoeia.

[0028] Tangerine peel (Citrus reticulata Blanco) is the dried, mature peel of the Rutaceae plant and its cultivars. It is categorized as either "Citrus reticulata" or "Guangcheng tangerine peel" (Guangcheng tangerine peel). The ripe fruit is harvested, the peel removed, and then sun-dried or low-temperature dried. The standard for tangerine peel is included in Part 1 of the 2020 edition of the Chinese Pharmacopoeia.

[0029] Amomum villosum is the dried mature fruit of Amomum villosum Lour., Amomum villosum Lour. var. xanthioides TLWu et Senjen, or Amomum longiligulare TLWu, all of the Zingiberaceae family. The fruit is harvested in summer and autumn when ripe and then sun-dried or low-temperature dried. The standard for Amomum villosum is included in Volume 1 of the 2020 edition of the Chinese Pharmacopoeia.

[0030] Polygonum multiflorum is the dried root tuber of Polygonum multiflorum Thunb., a plant in the Polygonaceae family. It's harvested in autumn and winter when the leaves wither. The roots are trimmed of their ends, washed, and large ones cut into chunks and dried. The standard for Polygonum multiflorum is included in Volume 1 of the 2020 edition of the Chinese Pharmacopoeia.

[0031] Ferrous sulfate should contain 98.5%-104.0% FeSO4·7H2O. The standard for ferrous sulfate is included in Part II of the 2020 edition of the Chinese Pharmacopoeia.

[0032] Hawthorn is the dried mature fruit of Crataegus pinnatifida Bge. var. Major NEBr. or Crataegus pinnatifida Bge., a plant of the Rosaceae family. The fruit is harvested in autumn when ripe, sliced, and dried. The standard for hawthorn medicinal materials is included in Part 1 of the 2020 edition of the Chinese Pharmacopoeia.

[0033] Compared with the prior art, the advantages and beneficial effects of the present invention are:

[0034] (1) The present invention provides a method for preparing Weixuekang granules, which adopts a method in which the filtrate obtained from each extraction is directly concentrated and then mixed in a concentration tank after concentration. This method overcomes the shortcomings of high energy consumption and long time consumption before the change, is conducive to energy conservation and emission reduction, improves production efficiency, helps enterprises achieve low-carbon and environmental protection goals in the drug production process, and promotes the sustainable development of the traditional Chinese medicine industry. By simplifying the process and shortening the operation time, the new method significantly improves the output efficiency per unit time, which not only improves the equipment utilization rate, but also reduces labor and management costs, thereby reducing the production cost of Weixuekang granules as a whole and enhancing the market competitiveness of the product.

[0035] (2) Based on the existing technology, the present invention moderately reduces the relative density of the clear paste, effectively solving a series of practical problems caused by the excessive viscosity of the clear paste in the traditional preparation method. This improvement not only reduces the adhesion of the clear paste in the pipeline, improves the discharge efficiency, and reduces material waste, but also significantly improves the difficulty of equipment cleaning and improves the continuity and convenience of production operations. In addition, the reasonable control of the viscosity of the clear paste is also conducive to the uniform mixing of subsequent materials, improving the process stability of the preparation and the consistency of product quality.

[0036] (3) In the process of preparing Weixuekang granules, the present invention uses stevioside as an excipient, completely replacing the sucrose commonly used in traditional preparations, and successfully realizes the production of sucrose-free granules. This improvement not only retains the good taste of the preparation, but also fully considers the medication needs of people with diabetes, obesity, and other conditions who need to control their sugar intake, significantly improving the applicability and safety of the drug. This design conforms to the current development trend of the pharmaceutical market for healthy and functional preparations, further expands the target population and application range of Weixuekang granules, and has good social value and broad market prospects.

[0037] (4) The present invention adopts a new process of directly concentrating and mixing the filtrate obtained from each extraction to obtain a clear paste, and on the basis of optimizing the relative density of the clear paste, adds specific excipients and adopts a specific granulation method to obtain Weixuekang granules. The results of the accelerated stability test and the long-term stability test show that the prepared granules have no significant changes in key quality indicators such as properties and content, the product stability is good, and it has consistency and equivalence compared with the traditional process. This achievement not only verifies the scientific nature and feasibility of the new process, but also fully reflects its significant advantages in ensuring drug quality, improving production efficiency and adapting to industrial continuous production, laying a solid foundation for the large-scale and standardized production of Weixuekang granules.

[0038] (5) The preparation method of the Weixuekang granules provided by the present invention has been systematically verified in practical applications. The results show that its production process is scientific and reasonable, highly operable, and has good industrial feasibility. The prepared Weixuekang granules meet the current pharmaceutical standards and relevant regulations in all quality index tests, and the product quality is stable and controllable. Compared with the traditional preparation process, the products produced by the new process show a high degree of consistency and equivalence. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 These are the TLC spectra of dried tangerine peel after 0 month storage, 6-month accelerated storage, and 24-month long-term storage of the Weixuekang granules prepared in Example 17.

[0040] Figure 2These are the TLC spectra of emodin in the Weixuekang granules prepared in Example 17 after 0 month storage, 6-month accelerated test, and 24-month long-term storage.

[0041] Figure 3 These are the TLC spectra of 5-hydroxymethylfurfural of the Weixuekang granules prepared in Example 17 after 0 month storage, 6-month accelerated test, and 24-month long-term storage.

[0042] Figure 1-3 Middle, left picture: 0 months, middle picture: accelerated 6 months; right picture: long-term storage 24 months; the numbers on the picture represent: 1 is batch 1, 2 is batch 2, 3 is control medicinal material, and 4 is batch 3.

[0043] Figure 4 This is a spectrum showing the hesperidin content of the Weixuekang granules (batch 1) prepared in Example 17 after storage for 0 months.

[0044] Figure 5 This is the hesperidin content determination spectrum of the Weixuekang Granules (Batch 1) prepared in Example 17 after 6 months of acceleration.

[0045] Figure 6 This is the hesperidin content determination spectrum of the Weixuekang granules (batch 1) prepared in Example 17 after long-term storage for 24 months. DETAILED DESCRIPTION

[0046] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0047] The pharmaceutical excipients used in the following examples of the present invention are all commercially available products and comply with Part IV of the 2020 edition of the Chinese Pharmacopoeia:

[0048] Dextrin, Liaoning Dongyuan Pharmaceutical Co., Ltd.

[0049] Stevioside, Hunan Erkang Pharmaceutical Co., Ltd.

[0050] Maltodextrin, Xi'an Tianzheng Pharmaceutical Excipients Co., Ltd.

[0051] Microcrystalline cellulose, Xidian Pharmaceutical Technology Group Co., Ltd., model PH-102.

[0052] Hydroxypropyl cellulose (highly substituted hydroxypropyl cellulose), Xi'an Tianzheng Pharmaceutical Excipients Co., Ltd.

[0053] Example 1-6 provides a method for preparing Weixuekang granules, comprising the following steps:

[0054] (1) Weigh the following ingredients according to the formula: Codonopsis pilosula 120 g, Rehmannia root 160 g, black beans 160 g, Chinese yam 240 g, dried tangerine peel 240 g, Amomum villosum 20 g, Polygonum multiflorum 138 g, ferrous sulfate 20 g, and hawthorn 120 g;

[0055] (2) extracting volatile oil from Amomum villosum and half of dried tangerine peel by steam distillation for 3 hours, specifically: adding 1 / 2 of the total weight of Amomum villosum and half of dried tangerine peel to moisten for 30 minutes, then adding 3 times the total weight of Amomum villosum and half of dried tangerine peel to water, steam distilling for 3 hours, collecting volatile oil, and collecting the residue; mixing the residue with the remaining dried tangerine peel, Codonopsis pilosula, Rehmannia root, black bean, Chinese yam, Polygonum multiflorum, and Crataegus pinnatifida, adding 6 times the amount of water and decocting twice, each time for 2 hours, and filtering respectively; concentrating the filtrates of the two decoctions at 60° C. to a relative density of 1.12, mixing, adding ethanol to make the alcohol content reach 60%, standing for 12 hours, taking the supernatant, recovering ethanol, cooling to room temperature, filtering, and concentrating the filtrate at 60° C. to a relative density of 1.27 to obtain a clear paste;

[0056] (3) Add ferrous sulfate to the clear paste, stir and mix thoroughly, add dextrin; the amount of dextrin is shown in Table 1, mix thoroughly, and wet granulate. The wet granulation conditions are as follows: use a 95% ethanol aqueous solution as a wetting agent to adjust the dryness and humidity of the soft material so that the soft material can be grasped into a ball and then dispersed when pressed. Granulate using a 14-mesh galvanized iron screen double-drum swing granulator; then use a vacuum suction horizontal boiling dryer to dry. The drying conditions are: bed temperature 70°C, drying time 30 minutes / bed, spray volatile oil, mix thoroughly, and seal for 30 minutes to obtain Weixuekang granules. The results are shown in Table 1.

[0057] Table 1 Dextrin dosage and test results

[0058]

[0059] As shown in Table 1, the ratio of dextrin to clear paste affects the difficulty of granulation, and Examples 2-4 have better granulation effects.

[0060] The difference between Examples 7-12 and Example 3 is that, because the taste is poor and bitter when dextrin is used as a diluent, an appropriate amount of sweetener is added to correct the taste. Specifically, ferrous sulfate is added to the clear paste, stirred and mixed, and then dextrin and sweetener are added. The specific addition amounts are shown in Table 2.

[0061] Table 2 Results of flavoring agent investigation

[0062]

[0063]

[0064] As shown in Table 2, steviol glycosides have a good taste and their sweetness varies little. In contrast, aspartame has a slightly worse taste and poor stability to acid and heat. It can be decomposed into phenylalanine, aspartic acid, and methanol by human gastrointestinal enzymes, making it unsuitable for patients with phenylketonuria. Taking all factors into consideration, Example 11, which uses steviol glycosides as the sweetener for this product, has the best taste.

[0065] The difference between Examples 13-20 and Example 11 is that a filler is added. Specifically, ferrous sulfate is added to the clear paste and stirred to mix thoroughly. Dextrin, steviol glycosides, and the filler are added and mixed thoroughly. See Table 3 for details.

[0066] Table 3 Investigation results of fillers

[0067]

[0068]

[0069] Table 3 shows that the type of filler also affects the difficulty of granulation. Among them, maltodextrin and microcrystalline cellulose, and maltodextrin and hydroxypropyl cellulose, are easy to granulate.

[0070] Example 21

[0071] The difference between this comparative example and Example 17 is that the drying method is belt vacuum drying, and the conditions for belt vacuum drying are: the temperature of zone 1 is 110°C, the temperature of zone 2 is 115°C, the temperature of zone 3 is 80°C, the temperature of zone 4 is 40°C, the feed rate is 15Hz, and the vacuum degree is 110kPa.

[0072] Example 22

[0073] The difference between this embodiment and embodiment 17 is that the drying method is: spray drying: inlet air temperature is 150°C, outlet air temperature is 80°C, sweep air heating temperature is 60°C, atomization pressure is 0.2 MPa, and feed rate is 50 kg / h.

[0074] The performance of the Weixuekang granules prepared in Examples 11 and 17-22 and the Weixuekang granules prepared by a traditional method (Jiangxi Nanchang Sanghai Pharmaceutical Co., Ltd., batch number: 200404) was tested. The results are shown in Table 4. Each bag contained 10 g of the granules.

[0075] Table 4. Storage 0-month test results

[0076]

[0077]

[0078] It can be seen from Table 4 that the Weixuekang granules prepared in Examples 11 and 17-22 all meet the standards of Weixuekang granules without storage.

[0079] Stability performance test

[0080] The stability of the Weixuekang granules prepared in Examples 11 and 17-22 and the Weixuekang granules prepared by the traditional method (Jiangxi Nanchang Sanghai Pharmaceutical Co., Ltd., batch number: 200404) was tested.

[0081] (1) Accelerated test: The Weixuekang granules were placed in commercial packaging at a temperature of 40°C ± 2°C and a relative humidity of 75% ± 5% for 6 months. Samples were taken at the end of 6 months for testing to examine their stability. The results are shown in Table 5.

[0082] Table 5 Accelerated test results

[0083]

[0084]

[0085] As shown in Table 5, the type of filler used in the formulation has a significant impact on the accelerated stability of Weixuekang Granules. The accelerated stability of Weixuekang Granules prepared in Examples 17-19 met the standards. Example 20, which used maltodextrin and hydroxypropyl cellulose as fillers, did not meet the relevant index requirements after accelerated testing. Examples 21 and 22 used different drying methods, and the accelerated stability of Weixuekang Granules also decreased.

[0086] (2) Long-term test: The Weixuekang granules were placed in the commercial packaging at a temperature of 20°C ± 2°C and a relative humidity of 60% ± 10%. After 24 months, samples were taken for testing to examine their stability. The results are shown in Table 6.

[0087] Table 6 Long-term stability test results

[0088]

[0089]

[0090] As shown in Table 6, the type and ratio of fillers and the drying method all have a significant impact on the long-term stability test. The present invention, by using specific excipients and a specific drying method, helps improve the stability of Weixuekang granules after changing the process (extract concentration method and relative density after concentration). The stability of Weixuekang granules prepared by Example 17 is consistent with that of the traditional method, meeting the relevant index requirements.

[0091] Figure 1-3 The TLC spectra of dried tangerine peel, emodin and 5-hydroxymethylfurfural of the Weixuekang granules prepared in Example 17 were tested after 0 month storage, 6-month accelerated test and 24-month long-term storage, respectively. The spectra show that the Weixuekang granules prepared in Example 17 have excellent stability.

[0092] Trait testing

[0093] The properties of Example 17 and the Weixuekang granules prepared by the traditional method (Jiangxi Nanchang Sanghai Pharmaceutical Co., Ltd., batch number: 200404) were tested. The results are shown in Table 7.

[0094] Table 7 Test results of properties of Weixuekang granules

[0095]

[0096] The properties of Weixuekang Granules are specified as follows: brown to tan granules; fragrant aroma, sweet and slightly sour taste. Three batches of samples prepared by the present invention and traditional methods all met the requirements.

[0097] The Weixuekang granules of the present invention revise the traditional process of combining the extracts and then concentrating them into a process of directly concentrating the extracts, adjust the relative density of the clear paste, and add specific excipients to ensure that there is no effect on the stability, dissolution or release behavior of the prepared drugs, no significant effect on the absorption and utilization of the drugs, and no significant changes in safety and effectiveness.

[0098] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A method for preparing Weixuekang granules, characterized in that: The following steps are involved: (1) Weigh the following ingredients: Codonopsis pilosula, Rehmannia root, black beans, Chinese yam, dried tangerine peel, Amomum villosum, Polygonum multiflorum, ferrous sulfate, and hawthorn; (2) extracting volatile oil from Amomum villosum and half of dried tangerine peel by steam distillation, and collecting the residue; mixing the residue with the remaining dried tangerine peel, Codonopsis pilosula, Rehmannia root, black beans, Chinese yam, Polygonum multiflorum, and Crataegus pinnatifida, decocting twice, and filtering each; concentrating the filtrates of the two decoctions, mixing to obtain a mixed filtrate, adding a solvent to the mixed filtrate, letting it stand, taking the supernatant, filtering, and concentrating the filtrate to obtain a clear paste; (3) Add ferrous sulfate, stevioside, filler and diluent to the clear paste, mix well, granulate, dry, spray volatile oil, mix well, and obtain Weixuekang granules.

2. The method for preparing Weixuekang granules according to claim 1, characterized in that: The filler is maltodextrin and microcrystalline cellulose in a mass ratio of (2-3):

1.

3. The method for preparing Weixuekang granules according to claim 1, characterized in that: The diluent is dextrin.

4. The method for preparing Weixuekang granules according to claim 1, characterized in that: The prescription raw materials are weighed according to the following mass parts: 100-200 parts of Codonopsis pilosula, 100-200 parts of Rehmannia root, 100-200 parts of black beans, 200-300 parts of yam, 200-300 parts of dried tangerine peel, 10-100 parts of Amomum villosum, 100-200 parts of Polygonum multiflorum, 10-50 parts of ferrous sulfate, and 50-150 parts of hawthorn.

5. The method for preparing Weixuekang granules according to claim 1, characterized in that: In the step (2), the medicinal residue is mixed with the remaining dried tangerine peel, codonopsis pilosula, prepared rehmannia root, black beans, yam, polygonum multiflorum and hawthorn, and decocted twice, each time for 1-3 hours.

6. The method for preparing Weixuekang granules according to claim 1, characterized in that: In the step (2), the filtrates from the two decoctions are respectively concentrated to a relative density of 1.10-1.

15.

7. The method for preparing Weixuekang granules according to claim 1, characterized in that: In the step (2), the supernatant is taken, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 to obtain a clear paste.

8. The method for preparing Weixuekang granules according to claim 1, characterized in that: The drying method in step (3) is to use a vacuum suction horizontal boiling dryer for drying.

9. The method for preparing Weixuekang granules according to claim 8, characterized in that: The drying conditions are: bed temperature 70-75℃, drying time 20-40 minutes / bed.

10. Weixuekang granules prepared according to the preparation method according to any one of claims 1 to 9.

Images