Traditional Chinese medicine composition for treating kidney stone as well as preparation method and application thereof

Abstract

The invention relates to a traditional Chinese medicine composition for treating kidney stone and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition for treating kidney stone is prepared from the following raw materials: poria cocos, cinnamon, bighead atractylodes rhizome, endothelium corneum gigeriae galli, lysimachia christinae hance, spora lygodii, radix curcumae and talc. According to the traditional Chinese medicine composition for treating the kidney stone and the preparation method and application thereof, the traditional Chinese medicine composition can tonify and strengthen the kidney and remove the stone, is high in safety, free of toxic and side effects, good in curative effect on the kidney stone, low in cost, economical and practical, easy to accept by patients, not prone to relapse after the kidney stone is removed, capable of treating both symptoms and root causes and free of toxic and side effects. The curative effect on kidney stone is obvious.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating kidney stones, and a preparation method and application thereof. Background Art

[0002] Kidney stones refer to the abnormal accumulation of some crystals (such as oxalic acid, uric acid, cystine, etc.) and organic matter (matrix proteins and acidic mucopolysaccharides, etc.) in the kidneys. Most kidney stones are located in the renal pelvis, and the stones can move downward and stay in the ureter and bladder.

[0003] Kidney stones are often found during physical examinations and ultrasound examinations, and urine tests are negative or contain a small amount of red and white blood cells. During attacks of pain and hematuria, sand or small stones may be excreted in the urine. When the stones pass through the urethra, the urine flow is blocked and there is stinging pain in the urethra. The urine flow will immediately resume after the stones are expelled. Pyuria may occur when there is concurrent infection, and acute attacks may cause chills, fever, lower back pain, frequent urination, urgency, and pain when urinating. Obstruction caused by a kidney stone on one side can cause hydronephrosis and progressive renal insufficiency on that side. Bilateral kidney stones or a solitary kidney stone can cause obstruction, and worsening of the condition can lead to serious adverse consequences such as severe urinary tract infection, acute renal impairment, and uremia.

[0004] The causes of kidney stones are complex, mainly including: ① Hypercalciuria: Persistent hypercalciuria is the most common independent abnormal factor in patients with kidney stones. ② Hyperoxaluria: Oxalic acid is the second most important component of kidney stones besides calcium. Oxalic aciduria is more common in intestinal oxalic acid absorption abnormalities, accounting for 2% of patients with kidney stones. ③ Hyperuricuria: Hyperuricuria is the only biochemical abnormality in 10% to 20% of patients with calcium oxalate stones, and as an independent type of kidney stone, 40% of patients with hyperuricuria have both hypercalciuria and hypocitraturia. ④ Homocystinuria: Due to renal tubular transport disorders, a large amount of cystine is excreted in the urine. ⑤ Xanthinuria: Due to the lack of xanthine oxidase, the conversion of hypoxanthine to xanthine and xanthine to uric acid is blocked, resulting in increased urinary xanthine (13mmol / 24h) and decreased uric acid.

[0005] In addition, persistent or recurrent urinary tract infections can cause infectious stones. Bacteria such as Proteus, certain Klebsiella, Serratia, Enterobacter aerogenes, and Escherichia coli can decompose urea in urine to produce ammonia, which increases the pH of urine and causes magnesium ammonium phosphate and carbonate phosphate to become supersaturated. Pus and necrotic tissue during infection also cause crystals to accumulate on their surfaces to form stones. In some diseases with abnormal kidney structure, such as ectopic kidney, polycystic kidney, and horseshoe kidney, kidney stones can occur due to repeated infections and poor urine flow. Infection is also a complication of other types of kidney stones, and they are mutually causal. Other factors such as climate, water quality, genetics, gender, age, diet, and occupation that affect the formation of kidney stones need further study.

[0006] Treatment for kidney stones should be tailored to the patient's general condition, stone location, size, composition, presence of obstruction, infection, hydrops, degree of renal parenchymal damage, and recurrence. This includes increasing urine volume by drinking more water and reducing urine saturation, which contributes to stone formation. Dietary adjustments should be made, primarily by reducing intake of milk, dairy products, and animal protein, and consuming more foods rich in plant fiber. Thiazide diuretics: Thiazides directly stimulate calcium reabsorption in the distal convoluted tubule, promoting sodium excretion. Sodium cellulose phosphate, when taken orally, binds to calcium in the intestine, reducing intestinal calcium absorption. Increased urinary citrate levels can reduce calcium oxalate saturation, reducing calcium crystallization and stone formation. Patients with dietary oxalate and its precursors should avoid foods and medications rich in oxalate and its precursors. Vitamin B6 deficiency prevents the conversion of glyoxylate to glycine, which is converted to oxalate through oxidation. Low-dose vitamin B6 can be used to treat the resulting hyperoxaluria. Uric acid stones account for 50% to 60% of kidney stones, and the goal of treatment is to reduce the concentration of uric acid in the urine. Infectious stones account for approximately 2% to 20% of all stones. One type is stones formed by urinary tract infection, and the other is stones formed by secondary infection of stones of other components. The principle of treatment for infectious stones is to completely remove the stones and eradicate the urinary tract infection. Extracorporeal shock wave lithotripsy or surgical treatment, such as pyelolithotomy, nephrolithotomy, and percutaneous nephrolithotomy, can be used. Traditional Chinese Medicine treatment for kidney stones falls under the category of stranguria stones, and treatment methods focus on clearing dampness and heat, promoting stranguria and expelling stones, including Chinese patent medicines such as various stone-removing granules.

[0007] In summary, Chinese medicine treatment of kidney stones can avoid surgical damage to renal tissue, or can be used to treat residual stones after surgery, varying degrees of hydronephrosis after surgery, recurrence of kidney stones after surgery, and other symptoms. While removing stones, Chinese medicine can nourish and strengthen the kidneys, which has the advantage of treating both the symptoms and the root cause. Summary of the Invention

[0008] In order to solve the above technical problems, the purpose of the present invention is to provide a traditional Chinese medicine composition for treating kidney stones, and its preparation method and application. The traditional Chinese medicine composition of the present invention can nourish and strengthen the kidney, dissolve stones and expel stones, has high safety, no toxic side effects, has a good therapeutic effect on kidney stones, is low in cost, economical and affordable, is easily accepted by patients, is not prone to recurrence after kidney stones are expelled, treats both the symptoms and the root cause, and has a significant effect in treating kidney stones.

[0009] The technical solution of the present invention to solve the above technical problems is as follows:

[0010] The first object of the present invention is to provide a Chinese medicine composition for treating kidney stones, which is composed of the following raw materials: Poria cocos, cinnamon bark, Atractylodes macrocephala, chicken's gizzard lining, Lysimachia chinensis, Lysimachia ternata, Curcuma aromatica and talc.

[0011] Poria cocos: Sweet, light, and neutral in nature, it enters the Heart, Spleen, and Lung meridians. It has the effects of dispelling dampness, strengthening the spleen and replenishing the middle, calming the mind, promoting diuresis, and protecting the liver. It can treat diarrhea, insomnia, edema, palpitations, and cancer, as well as urinary problems and forgetfulness.

[0012] Cinnamon bark: Pungent and sweet, with a very warming nature, it enters the kidney, spleen, heart, and liver meridians. It has the effects of tonifying fire and supporting yang, guiding fire back to its source, dispersing cold and relieving pain, and warming and unblocking the meridians. It is commonly used to treat impotence, uterine coldness, cold pain in the waist and knees, asthma due to kidney deficiency, floating yang deficiency, dizziness and red eyes, cold pain in the heart and abdomen, vomiting and diarrhea due to deficiency-cold, hernia, abdominal pain, dysmenorrhea, and amenorrhea.

[0013] Atractylodes macrocephala: Sweet and bitter in flavor, warm in nature, it enters the spleen and stomach meridians. Its primary benefits include strengthening the spleen, replenishing qi, drying dampness, promoting diuresis, stopping sweating, and stabilizing pregnancy. Clinically, it is used to treat spleen deficiency-related symptoms such as poor appetite, diarrhea, abdominal distension, phlegm and fluid retention, dizziness, palpitations, and edema, spontaneous sweating, and fetal movement disorder.

[0014] Chicken Gizzard Stone: Sweet in flavor and neutral in nature, it enters the spleen, stomach, small intestine, and bladder meridians. It has the benefits of promoting digestion, strengthening the stomach, and astringing sperm to stop nocturnal emission. It is primarily used to treat indigestion, nocturnal emission, enuresis, stranguria with stones and pain, and biliary distension and flank pain.

[0015] Centella asiatica: Bitter and sour in flavor, slightly cold in nature. It clears heat and detoxifies, promotes urination and expelling stones, and promotes blood circulation and dissipates blood stasis. It is used for liver and gallstones, cholecystitis, icteric hepatitis, urinary tract stones, edema, traumatic injuries, snake bites, poisonous mushrooms, and drug poisoning; it can also be used externally to treat suppurative inflammation and burns.

[0016] Lycoris radiata (Lycoris radiata) has a sweet and salty flavor and a cold nature. It enters the bladder and small intestine meridians. It clears heat and dampness, relieves stranguria and relieves pain, and is commonly used to treat symptoms such as stranguria caused by heat, stranguria caused by sand, stranguria caused by stones, stranguria caused by blood, stranguria caused by grease, and urethral pain. Lycoris radiata also has diuretic and choleretic properties, treating edema and dysuria. It also promotes bile secretion, aiding in the treatment of gallstones, cholecystitis, and other conditions.

[0017] Curcuma: pungent, bitter, cold in nature, enters the heart, liver, and gallbladder meridians. Its efficacy is to promote blood circulation and relieve pain, promote qi and relieve depression, clear away heat and cool blood, clear the heart and open the orifices, and promote dampness and reduce jaundice. It is mainly used clinically for chest and flank pain, irregular menstruation, increased scabs and skin lumps, hematemesis, epistaxis, retrograde menstruation in women, coma caused by dampness, epilepsy caused by phlegm heat, and jaundice caused by dampness heat.

[0018] Talc: Sweet and bland in flavor, with a cold nature, it enters the Stomach and Bladder meridians. Its primary benefits are diuresis, relieving stranguria, and clearing away summer heat. It can clear dampness and heat, and is particularly effective at clearing heat accumulation in the bladder, unblocking the waterways, and treating stranguria caused by heat and stones. It is clinically used to treat acute urinary tract infections, urinary stones, and acute pyelonephritis.

[0019] The beneficial effects of the present invention are as follows: the Chinese medicine composition prepared by the present invention has an orderly compatibility of the main medicine, the auxiliary medicine and the adjuvant medicine, and the formula is reasonable. It has been verified by many years of clinical application that the therapeutic effect is significant, the medicinal properties are balanced, and there are no toxic side effects. The combination of Poria cocos, cinnamon bark, Atractylodes macrocephala, chicken's gizzard lining, Lysimachia chinensis, Lysimachia ternata, Curcuma aromatica, talc and other medicines has the effects of tonifying the kidney, strengthening the kidney, and dissolving stones and expelling stones.

[0020] On the basis of the above technical solution, the present invention can also be improved as follows.

[0021] Furthermore, the invention is composed of the following raw materials in parts by weight: 30-60 parts of Poria cocos, 20-40 parts of cinnamon bark, 40-60 parts of Atractylodes macrocephala, 40-60 parts of Gallus gallus domesticus, 40-60 parts of Lysimachia chinensis, 20-40 parts of Lysimachia ternata, 30-50 parts of Curcuma aromatica, and 30-50 parts of talc.

[0022] Furthermore, the invention is composed of the following raw materials in parts by weight: 35-55 parts of Poria cocos, 25-35 parts of cinnamon bark, 45-55 parts of Atractylodes macrocephala, 45-55 parts of Gallus gallus domesticus, 45-55 parts of Lysimachia chinensis, 25-35 parts of Lysimachia ternata, 35-45 parts of Curcuma aromatica, and 35-45 parts of talc.

[0023] Further, it is composed of the following raw materials in parts by weight:

[0024] 50 parts of Poria cocos, 30 parts of cinnamon bark, 50 parts of Atractylodes macrocephala, 50 parts of chicken's gizzard lining, 50 parts of Herba Lysimachiae, 30 parts of Lycopodiellae, 40 parts of Curcuma aromatica, and 40 parts of Talcum.

[0025] A second object of the present invention is to provide a method for preparing a Chinese medicine composition for treating kidney stones, comprising the following steps:

[0026] The following raw materials are weighed separately: Poria cocos, cinnamon bark, Atractylodes macrocephala, Gallus gallus domesticus, Lysimachia chinensis, Lysimachia ternata, Curcuma aromatica, and talc, and are crushed and sieved separately, and then mixed evenly to obtain the traditional Chinese medicine composition for treating kidney stones.

[0027] Furthermore, the traditional Chinese medicine composition for treating kidney stones is used to prepare medicine for treating kidney stones.

[0028] The third object of the present invention is to provide a medicine for treating kidney stones, which is prepared by adding one or more pharmaceutically acceptable excipients to the traditional Chinese medicine composition for treating kidney stones and preparing a decoction, ointment, pill, granule or capsule according to conventional processes.

[0029] Furthermore, the preparation method of the decoction comprises the following steps:

[0030] Take the Chinese medicinal composition for treating kidney stones according to claim 7, soak it in water, add water and boil it twice, combine the decoction each time to obtain a decoction.

[0031] Furthermore, the water is added and decocted twice, the first time water is added being 5 times the weight of the traditional Chinese medicine composition for treating kidney stones; the second time water is added being 3 times the weight of the traditional Chinese medicine composition for treating kidney stones.

[0032] Furthermore, the adding water and decocting the mixture twice, with the decocting time being 2 hours and 1.5 hours respectively.

[0033] The beneficial effects of the present invention are: the medicine prepared by the present invention is highly safe, has no toxic side effects, has a good therapeutic effect on kidney stones, is low in cost, is economical and affordable, is easily accepted by patients, is not prone to recurrence after kidney stones are discharged, treats both the symptoms and the root cause, and has a significant therapeutic effect on kidney stones. DETAILED DESCRIPTION

[0034] The principles and features of the present invention are described below. The examples are only used to explain the present invention and are not intended to limit the scope of the present invention. Where specific techniques or conditions are not specified in the examples, the techniques or conditions described in the literature in this field or the product instructions are used. Where the manufacturers of the reagents or instruments used are not specified, they are all conventional products that can be purchased through regular channels.

[0035] Example 1:

[0036] The preparation method of the Chinese medicine composition for treating kidney stones of this embodiment comprises the following steps:

[0037] The following raw materials were weighed separately: 50 g of Poria cocos, 30 g of cinnamon bark, 50 g of Atractylodes macrocephala, 50 g of Gallus gallus domesticus, 50 g of Lysimachia chinensis, 30 g of Lysimachia ternata, 40 g of Curcuma aromatica, and 40 g of talc, and were crushed through a 100-mesh sieve and then mixed uniformly to obtain a traditional Chinese medicine composition for treating kidney stones.

[0038] The drug for treating kidney stones of this embodiment is prepared by adding one or more pharmaceutically acceptable excipients to the above-mentioned traditional Chinese medicine composition and preparing the drug into a decoction, paste, pills, granules or capsules according to conventional processes.

[0039] The preparation method of the decoction is as follows:

[0040] The Chinese medicinal composition for treating kidney stones is soaked in water, decocted twice with water added, 5 times and 3 times the weight of water each time, and the decocting time each time is 2 hours and 1.5 hours respectively. The decoctions are combined to obtain a decoction.

[0041] Examples 2-3:

[0042] Examples 2 to 3 are the same as Example 1, and the only difference is the specific composition ratio of the Chinese medicine composition. The specific composition ratio of the Chinese medicine composition of Examples 2 to 3 is shown in Table 1:

[0043] Table 1 (unit: g)

[0044] Group Poria cocos Cinnamon Atractylodes macrocephala Chicken gizzard Moneywort Sea gold sand Turmeric talc Example 2 35 25 45 45 45 25 35 35 Example 3 55 35 55 55 55 35 45 45

[0045] Comparative Examples 1 to 4:

[0046] Comparative Examples 1 to 4 are the same as Example 1, the only difference being the specific composition ratios of the Chinese medicine compositions. The specific composition ratios of the Chinese medicine compositions of Comparative Examples 1 to 6 are shown in Table 2:

[0047] Table 2 (unit: g)

[0048] Group Poria cocos Cinnamon Atractylodes macrocephala Chicken gizzard Moneywort Sea gold sand Turmeric talc Comparative Example 1 0 30 50 50 50 30 40 40 Comparative Example 2 50 0 50 50 50 30 40 40 Comparative Example 3 50 30 0 50 50 30 40 40 Comparative Example 4 50 30 50 0 50 30 40 40 Comparative Example 5 50 30 50 50 0 0 40 40 Comparative Example 6 50 30 50 50 50 30 0 0

[0049] Test example:

[0050] 1.1 General Information

[0051] This study involved 400 patients with kidney stones admitted between November 2013 and November 2014. They were randomly divided into eight groups, experimental and control groups 1 to 7. Statistical analysis showed no statistically significant differences in the basic data between the experimental and control groups (P > 0.05).

[0052] 1.2 Treatment methods:

[0053] The experimental group took the traditional Chinese medicine prepared in Example 1 of the present invention, twice a day, a course of treatment of 3 days, and a total of 2 courses of treatment; the control groups 1 to 6 took the traditional Chinese medicine prepared in comparative examples 1 to 6, twice a day, a course of treatment of 3 days, and a total of 2 courses of treatment; the control group 7 chose Western medicine treatment, orally taking progesterone soft capsules, 2 times a day, 100 mg each time; orally taking furosemide tablets, once a day, 40 mg each time.

[0054] 1.3 Efficacy evaluation criteria

[0055] 1.3.1 Clinical efficacy

[0056] Markedly effective: All stones are expelled, clinical symptoms disappear completely, and no stones are found in ultrasound or X-ray examinations;

[0057] Effective: Some stones are expelled, clinical symptoms are significantly alleviated, and ultrasound and X-ray examinations show that the stones are smaller or reduced;

[0058] Ineffective: There is no significant change in clinical symptoms, and ultrasound or X-ray examinations reveal no significant change or aggravation of the stones.

[0059] Total effective rate = significant effective rate + improvement rate.

[0060] The test results are shown in Table 3:

[0061] Table 3

[0062]

[0063]

[0064] Table 3 shows that the total effective rate of experimental group 1 is higher than that of control groups 1 to 6, and slightly lower than that of the Western medicine treatment control group 7. The chi-square test showed that p < 0.01, indicating that there was a significant difference between the experimental group and the control groups 1 to 6, and the experimental group had better efficacy than the control group.

[0065] Typical cases:

[0066] (1) A 52-year-old male had three 4x5 mm stones in his renal pelvis. He took the Chinese medicine prepared by the present invention twice a day. After 4 days, the urinary frequency symptoms improved. After 12 days of taking the medicine, the stone fragments were excreted in the urine. He continued to take the medicine for 10 days and was cured without recurrence.

[0067] (2) A 48-year-old male suffered from kidney stones for more than a year. He had multiple kidney stones, the largest of which was 1.2×0.4 cm. He took the Chinese medicine prepared by the present invention twice a day. After taking it for 7 days, the number of kidney stones was significantly reduced. After taking it for 10 consecutive days, all the kidney stones were expelled.

[0068] (3) A 44-year-old female suffered from kidney stones for many years and had frequent lumbago. After examination, it was found that there were two stones in her kidney, one of which was 0.7×0.6 cm and the other was 0.4×0.8 cm. She took the Chinese medicine prepared by the present invention twice a day. After taking it for 4 days, her lumbago was significantly relieved. After taking it for 10 consecutive days, all the stones in her kidney were expelled.

[0069] Although the embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are illustrative and are not to be construed as limitations on the present invention. A person skilled in the art may change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A Chinese medicine composition for treating kidney stones, characterized in that: The invention is composed of the following raw materials: Poria cocos, cinnamon bark, Atractylodes macrocephala, chicken's gizzard lining, Centella asiatica, Lysimachia ternata, Curcuma aromatica and talc.

2. A Chinese medicine composition for treating kidney stones according to claim 1, characterized in that, The invention is composed of the following raw materials in parts by weight: 30-60 parts of Poria cocos, 20-40 parts of cinnamon bark, 40-60 parts of Atractylodes macrocephala, 40-60 parts of Gallus gallus domesticus, 40-60 parts of Lysimachia chinensis, 20-40 parts of Lysimachia ternata, 30-50 parts of Curcuma aromatica and 30-50 parts of talc.

3. A Chinese medicine composition for treating kidney stones according to claim 2, characterized in that, The invention is composed of the following raw materials in parts by weight: 35-55 parts of Poria cocos, 25-35 parts of cinnamon bark, 45-55 parts of Atractylodes macrocephala, 45-55 parts of chicken's gizzard lining, 45-55 parts of Lysimachia chinensis, 25-35 parts of Lysimachia ternata, 35-45 parts of Curcuma aromatica and 35-45 parts of talc.

4. A Chinese medicine composition for treating kidney stones according to claim 3, characterized in that, It is composed of the following raw materials in parts by weight: 50 parts of Poria cocos, 30 parts of cinnamon bark, 50 parts of Atractylodes macrocephala, 50 parts of chicken's gizzard lining, 50 parts of Herba Lysimachiae, 30 parts of Lycopodiellae, 40 parts of Curcuma aromatica, and 40 parts of Talcum.

5. A method for preparing a Chinese medicine composition for treating kidney stones according to any one of claims 1 to 4, characterized in that: The steps include: The following raw materials are weighed separately: Poria cocos, cinnamon bark, Atractylodes macrocephala, Gallus gallus domesticus, Lysimachia chinensis, Lysimachia ternata, Curcuma aromatica, and talc, and are crushed and sieved separately, and then mixed evenly to obtain the traditional Chinese medicine composition for treating kidney stones.

6. An application of a traditional Chinese medicine composition for treating kidney stones, characterized in that: The traditional Chinese medicine composition for treating kidney stones according to any one of claims 1 to 4 is used to prepare a medicine for treating kidney stones.

7. A medicine for treating kidney stones, characterized in that: Take the traditional Chinese medicine composition for treating kidney stones according to any one of claims 1 to 4, add one or more pharmaceutically acceptable excipients, and prepare it into a decoction, ointment, pills, granules or capsules according to conventional processes.

8. A medicine for treating kidney stones according to claim 7, characterized in that: The preparation method of the decoction comprises the following steps: Take the Chinese medicinal composition for treating kidney stones according to claim 7, soak it in water, add water and boil it twice, combine the decoction each time to obtain a decoction.

9. A medicine for treating kidney stones according to claim 8, characterized in that: The water is added and decocted twice, the first time water is added being 5 times the weight of the traditional Chinese medicine composition for treating kidney stones; the second time water is added being 3 times the weight of the traditional Chinese medicine composition for treating kidney stones.

10. The medicine for treating kidney stones according to claim 8, characterized in that: The water was added and decocted twice, with the decocting time being 2 hours and 1.5 hours respectively.

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