Blood sample analysis module

Abstract

The invention provides a blood sample analysis module which comprises a shell and an enclosing wall assembly, a cavity is formed in the shell, and a first through hole, a second through hole and a third through hole are formed in the shell; the enclosing wall assembly is arranged in the cavity and is in contact with the cavity to form a standard cavity and a contrast cavity, the first through hole and the second through hole are communicated with the standard cavity, and the third through hole is communicated with the contrast cavity; electrode assemblies are arranged on the cavity walls of the standard cavity and the contrast cavity; a first pipeline and a second pipeline are arranged on the peripheral side of the standard cavity and / or the contrast cavity of the enclosing wall assembly, the first pipeline is embedded into the first through hole, the second pipeline is embedded into the second through hole, and the first pipeline and the second pipeline are both communicated with the standard cavity. According to the blood sample analysis module provided by the embodiment of the invention, the enclosure wall assembly is arranged in the shell to form the standard cavity and the contrast cavity, and the first pipeline and the second pipeline which are communicated with the standard cavity are arranged on the enclosure wall assembly, so that external liquid of the blood sample analysis module can flow into and out of the standard cavity from the first pipeline and the second pipeline, and repeated measurement is realized.

Description

[0001] This application is a divisional application of the Chinese patent application submitted to the China Patent Office on May 9, 2022, with application number 202210501066.3 and patent name "Blood Sample Analysis Module". Technical Field

[0002] The present application relates to the field of medical device technology, and specifically to a blood sample analysis module. Background Art

[0003] In medical diagnosis, the measurement of some indicators of blood samples is very important in medical diagnosis and treatment, such as pH value, hematocrit, ion concentration (K+, Na+, Cl-, Ca2+), glucose, lactic acid, and O2, CO2 partial pressure, etc.

[0004] Blood gas and biochemistry test cards are widely used in the medical industry. These cards integrate biochemical test electrodes, which are cleaned with cleaning fluid and calibrated with calibration fluid before testing the test fluid (blood). Wastewater from the test process is stored on the card. However, due to the limited capacity of the card, it can typically only complete a single or very few rounds of measurements, limiting the number of measurements and hindering testing efficiency. Summary of the Invention

[0005] The present application aims to provide a blood sample analysis module to solve the defect that blood gas and biochemical test cards can generally only complete a single round or a very few rounds of measurement.

[0006] An embodiment of the present application provides a blood sample analysis module, which includes a shell and a wall assembly, wherein a cavity is provided in the shell and is provided with a first through hole, a second through hole, and a third through hole; the wall assembly is arranged in the cavity and contacts the cavity to form a standard cavity and a control cavity, the first through hole and the second through hole are connected to the standard cavity, and the third through hole is connected to the control cavity; the cavity walls of the standard cavity and the control cavity are both provided with an electrode assembly; wherein, a first pipe and a second pipe are provided on the peripheral side of the standard cavity and / or the control cavity of the wall assembly, the first pipe is embedded in the first through hole, the second pipe is embedded in the second through hole, and the first pipe and the second pipe are both connected to the standard cavity.

[0007] The blood sample analysis module provided in the embodiment of the present application is provided with a wall assembly in the cavity within the shell to form a standard chamber and a control chamber, and a first pipe and a second pipe are provided on the wall assembly to connect the standard chamber. The first pipe is embedded in the first through hole of the shell, and the second pipe is embedded in the second through hole of the shell to connect the inside and outside of the shell, so that the external liquid of the blood sample analysis module can flow into and out of the standard chamber through the first pipe and the second pipe, and the external liquid or the liquid pre-accommodated in the blood sample analysis module can flow into the control chamber through the third through hole. At the same time, the walls of the standard chamber and the control chamber are both provided with electrode assemblies to enable the blood sample analysis module to complete the corresponding measurement operation. After the measurement is completed, the liquid in the standard chamber will not be stored inside the blood sample analysis module, which can greatly reduce the volume of the blood sample analysis module. The liquid in the standard chamber can flow into and out of the blood sample analysis module through the first pipe and the second pipe respectively, so that the blood sample analysis module can perform multiple repeated measurements, greatly improving the number of measurements of the blood sample analysis module, eliminating the need for frequent replacement of the blood sample analysis module, and improving the testing efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] To more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For those skilled in the art, other drawings can be derived from these drawings without inventive effort.

[0009] Figure 1 is a schematic structural diagram of a blood sample analysis module in some embodiments of the present application;

[0010] Figure 2 yes Figure 1 Schematic diagram of the structure of the blood sample analysis module in the embodiment;

[0011] Figure 3 is a schematic diagram of the cross-sectional structure of a blood sample analysis module in some embodiments of the present application;

[0012] Figure 4 is a schematic structural diagram of a wall assembly in some embodiments of the present application;

[0013] Figure 5 yes Figure 4 A schematic diagram of the cross-sectional structure of the wall assembly along the AA direction in the embodiment;

[0014] Figure 6 is a schematic structural diagram of the first housing in some embodiments of the present application;

[0015] Figure 7 is another cross-sectional structural diagram of a blood sample analysis module in some embodiments of the present application;

[0016] Figure 8is a structural schematic diagram of the first shell in some other embodiments of the present application;

[0017] Figure 9 This is a partial structural diagram of a blood sample analysis module in some embodiments of the present application. DETAILED DESCRIPTION

[0018] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0019] References to "embodiments" herein mean that a particular feature, structure, or characteristic described in connection with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various places in the specification does not necessarily refer to the same embodiment, nor does it constitute an independent or alternative embodiment that is mutually exclusive of other embodiments. It is understood, both explicitly and implicitly, by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0020] The "blood sample analysis module" used herein may also be referred to as a "blood gas and biochemistry test card" or "test card." This blood sample analysis module can be used in conjunction with a blood gas analyzer to measure parameters such as pH, hematocrit, ion concentrations (K+, Na+, Cl-, Ca2+), glucose, lactate, and O2 and CO2 partial pressures in a blood sample. These parameters are typically measured using electrochemical or electrochemical impedance spectroscopy.

[0021] The term "blood gas analysis equipment," as used herein, may also be referred to as a "blood gas analyzer" or "blood gas biochemical analyzer," and utilizes blood gas analysis technology. Blood gas analysis technology refers to a technique used in blood gas analysis equipment to measure H+ concentration, dissolved gases (primarily CO2, O2, etc.) in a blood sample, and other parameters to understand a person's respiratory function and acid-base balance. It directly reflects lung ventilation function and its acid-base balance, and the specimen used is typically a blood sample.

[0022] See also Figure 1 , Figure 1 1 is a schematic structural diagram of a blood sample analysis module 100 in some embodiments of the present application. The blood sample analysis module 100 may generally include a shell 10 and a wall assembly 30 .

[0023] The housing 10 defines a cavity 101. The wall assembly 30 is disposed within the cavity 101 and contacts the cavity 101 to form a standard cavity 301 and a reference cavity 302. The housing 10 further defines a first through-hole 110, a second through-hole 120, and a third through-hole 130. The first through-hole 110 and the second through-hole 120 communicate with the standard cavity 301, while the third through-hole 130 communicates with the reference cavity 302.

[0024] Among them, the external liquid of the blood sample analysis module 100 can flow into and out of the standard cavity 301 through the first through hole 110 and the second through hole 120, and the external liquid or the liquid pre-accommodated in the blood sample analysis module 100 can flow into the control cavity 302 through the third through hole 130. Furthermore, the cavity walls of the standard cavity 301 and the control cavity 302 are both provided with an electrode assembly 50, so that the blood sample analysis module 100 can complete the corresponding measurement operation. It can be understood that the external liquid can be a cleaning liquid, a calibration liquid, a test liquid, etc., which flows from the outside of the blood sample analysis module 100 into the standard cavity 301 and can be used by the electrode assembly 50 to complete the corresponding cleaning, calibration, and testing operations. After the measurement is completed, the liquid in the standard cavity 301 can flow out of the blood sample analysis module 100 and will not be stored inside the blood sample analysis module 100, which can greatly reduce the volume of the blood sample analysis module 100. The liquid in the standard cavity 301 can flow into the blood sample analysis module 100, so that the blood sample analysis module 100 can achieve multiple repeated measurements, which greatly improves the number of measurements of the blood sample analysis module 100. There is no need to frequently replace the blood sample analysis module 100, and the measurement efficiency is high.

[0025] In one embodiment, the electrode assembly 50 generally includes a first test electrode group 51 exposed in the standard cavity 301 and a second test electrode group 52 exposed in the control cavity 302 .

[0026] In one embodiment, the housing 10 may further include a fourth through-hole 140 communicating with the cavity 101. The fourth through-hole 140 is not interconnected with the standard cavity 301 or the control cavity 302. The electrode assembly 50 may further include a third test electrode group 53 exposed in the fourth through-hole 140. Specifically, the third test electrode group 53 may be exposed to the exterior of the blood sample analysis module 100 via the fourth through-hole 140, thereby enabling the blood sample analysis module 100 to achieve signal connection with the blood gas analysis equipment via the third test electrode group 53 to transmit test-related signals. The first test electrode group 51 and the second test electrode group 52 are respectively signal-connected to the third test electrode group 53.

[0027] Furthermore, a first conduit 310 and a second conduit 320 are provided around the standard cavity 301 and / or the control cavity 302 of the wall assembly 30. The first conduit 310 is embedded in the first through-hole 110, and the second conduit 320 is embedded in the second through-hole 120. Both the first conduit 310 and the second conduit 320 communicate with the standard cavity 301, so that liquid outside the blood sample analysis module 100 can flow into and out of the standard cavity 301 through the first conduit 310 and the second conduit 320. Preferably, the first conduit 310 and the second conduit 320 are provided around the standard cavity 301 of the wall assembly 30.

[0028] It can be understood that in the embodiments of the present application, all directional indications (such as up, down, left, right, front, back, etc.) are only used to explain the relative position relationship, movement status, etc. between the various components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

[0029] See also Figure 2 , Figure 2 yes Figure 1 In the embodiment, the blood sample analysis module 100 is schematically disassembled. The housing 10 generally comprises a first housing 11 and a second housing 12 disposed on one side of the first housing 11. The first housing 11 can be connected to the second housing 12 by screwing, plugging, snapping, bonding, welding, or other connection methods, and together they form the cavity 101. Of course, in other embodiments, the first housing 11 and the second housing 12 can be integrally formed.

[0030] The first housing 11 can be made of a hard material such as plastic, resin, or polymer. For example, the first housing 11 can be made of materials such as ABS (Acrylonitrile Butadiene Styrene plastic), PDMS (Polydimethylsiloxane), PC (Polycarbonate), PMMA (Polymethyl methacrylate), PS (General purpose polystyrene), PP (Polypropylene), or COC (copolymers of cycloolefin), and can be manufactured by injection molding, CNC machining, or 3D printing.

[0031] The material of the second housing 12 can be the same as or different from that of the first housing 11. Preferably, the second housing 12 can be a circuit board with an electrode assembly 50, that is, the circuit board is provided with a first test electrode group 51, a second test electrode group 52, and a third test electrode group 53, wherein the first test electrode group 51 and the second test electrode group 52 are arranged on the same side of the circuit board, i.e., the second housing 12; the third test electrode group 53 and the first test electrode group 51 can be arranged on the same side of the circuit board, i.e., the second housing 12, or can be arranged on opposite sides of the second housing 12.

[0032] The first through hole 110 and the second through hole 120 respectively penetrate the second shell 12 to communicate with the standard cavity 301 , and the third through hole 130 penetrates the first shell 11 to communicate with the reference cavity 302 .

[0033] See also Figure 3 , Figure 3 : This is a schematic diagram of the cross-sectional structure of a blood sample analysis module 100 in some embodiments of the present application. A first receiving cavity 11a and a second receiving cavity 11b are respectively provided on opposite sides of the first shell 11. The second shell 12 is at least partially embedded in the first receiving cavity 11a and cooperates with the first shell 11 to enclose a cavity 101. In other words, the first receiving cavity 11a is provided on the side of the first shell 11 close to the second shell 12, and the second receiving cavity 11b is provided on the side of the first shell 11 away from the second shell 12. The wall assembly 30 is disposed between the first shell 11 and the second shell 12, and contacts the opposite sides of the cavity 101 to form a standard cavity 301 and a control cavity 302. That is, the opposite sides of the wall assembly 30 contact the first shell 11 and the second shell 12 to form the standard cavity 301 and the control cavity 302.

[0034] Preferably, the second shell 12 is embedded in the first receiving cavity 11a, and the outer periphery of the second shell 12 is adapted to the shape of the cavity wall of the first receiving cavity 11a. In one embodiment, the second shell 12 can be connected and fixed to the cavity wall of the first receiving cavity 11a by means of screwing, plugging, snapping, bonding, welding, etc. For example, at least one assembly structure (such as a positioning column, a positioning hole, etc.) is provided on the cavity wall of the first receiving cavity 11a, and a connecting structure (such as a positioning column, a positioning hole, etc.) adapted to the positioning structure is provided on the second shell 12. The assembly structure and the connecting structure cooperate to realize the assembly connection between the cavity wall of the first receiving cavity 11a and the second shell 12. Preferably, the assembly structure and the connecting structure can be arranged in a fool-proof manner to avoid the reverse installation phenomenon when the second shell 12 is assembled on the first shell 11.

[0035] The third through hole 130 extends through the wall of the second receiving chamber 11b, connecting the control chamber 302 and the second receiving chamber 11b via the third through hole 130. Preferably, the control chamber 302 is located on the wall of the second receiving chamber 11b adjacent to the first receiving chamber 11a, and the third through hole 130 extends through the wall of the second receiving chamber 11b adjacent to the first receiving chamber 11a, connecting the control chamber 302 and the second receiving chamber 11b. The fourth through hole 140 extends through the first housing 11 to connect to the first receiving chamber 11a, and is not connected to the standard chamber 301 or the control chamber 302.

[0036] Preferably, the shapes of the first through-hole 110, the second through-hole 120, the third through-hole 130, and the fourth through-hole 140 can be circular, rectangular, polygonal, or the like, without specific limitation. The first through-hole 110 and the second through-hole 120 are spaced apart and extend through the second housing 12. The axes of the first through-hole 110 and the second through-hole 120 are substantially parallel and spaced apart. The third through-hole 130 and the fourth through-hole 140 are spaced apart and extend through the wall of the first receiving cavity 11a and communicate with the first receiving cavity 11a. The axes of the third through-hole 130 and the fourth through-hole 140 are substantially parallel and spaced apart. Of course, in some embodiments, the axes of the first through-hole 110, the second through-hole 120, the third through-hole 130, and the fourth through-hole 140 are substantially parallel. It should be understood that the use of the terms "substantially" and "substantially" in this application with respect to numerical quantities or other quantifiable relationships (e.g., perpendicularity or parallelism) should be understood to indicate a quantity within ±10%. Thus, for example, lines that are substantially parallel to each other may be at an angle of between 0° and 10° to each other.

[0037] It should be noted that the terms "first," "second," etc., used herein are for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the technical features being referred to. Therefore, features designated as "first" or "second" may explicitly or implicitly include one or more of the aforementioned features.

[0038] See also Figure 4 and Figure 5 , Figure 4 is a schematic structural diagram of the wall assembly 30 in some embodiments of the present application, Figure 5 yes Figure 4 A schematic diagram of the cross-sectional structure of the wall assembly 30 along the AA line in the embodiment. The wall assembly 30 generally comprises a first wall 30a and a second wall 30b. The first wall 30a contacts two opposing surfaces of the cavity 101 to form a standard cavity 301, and the second wall 30b contacts the opposing surfaces of the cavity 101 to form a control cavity 302. The liquids in the standard cavity 301 and the control cavity 302 are not connected to each other.

[0039] Specifically, the first surrounding wall 30a has two opposing surfaces that contact the first and second housings 11 and 12, respectively, to form a standard cavity 301. The second surrounding wall 30b has two opposing surfaces that contact the first and second housings 11 and 12, respectively, to form a control cavity 302. A first conduit 310 and a second conduit 320 are provided around the first surrounding wall 30a. Preferably, the first conduit 310 and the second conduit 320 are provided on the side of the first surrounding wall 30a that contacts the second housing 12.

[0040] The first and second conduits 310, 320 are disposed at opposite ends of the first enclosure 30a and are both connected to the standard cavity 301, but are not connected to the reference cavity 302. The first and second enclosures 30a, 30b are disposed between the first and second housings 11, 12, such that the first and second housings 11, 12 cooperate to clamp the first and second enclosures 30a, 30b. The first and second enclosures 30a, 30b can be secured to the first and / or second housings 11, 12, by threading, plugging, snapping, welding, or bonding.

[0041] The first surrounding wall 30a is generally annular and is disposed around the periphery of the first test electrode group 51 so that the first test electrode group 51 is exposed to the standard cavity 301. The second surrounding wall 30b is generally annular and is disposed around the periphery of the second test electrode group 52 so that the second test electrode group 52 is exposed to the control cavity 302.

[0042] The first pipe 310 and the second pipe 320 are disposed on the same side of the first surrounding wall 30a and respectively penetrate the second housing 12. The first pipe 310 is inserted into the first through hole 110 and forms an interference fit with the inner wall of the first through hole 110 to achieve a seal; the second pipe 320 is inserted into the second through hole 120 and forms an interference fit with the inner wall of the second through hole 120 to achieve a seal.

[0043] In one embodiment, the wall assembly 30 can be made of a material with a certain degree of elasticity, such as rubber or silicone. For example, the wall assembly 30 can be made of silicone and can be formed using an integral molding process (e.g., injection molding) to form the first wall 30a, the second wall 30b, the first conduit 310, and the second conduit 320. Of course, in other embodiments, the first wall 30a, the second wall 30b, the first conduit 310, and the second conduit 320 can be separately molded and then assembled to form the wall assembly 30, which will not be described in detail.

[0044] Preferably, the wall assembly 30 is made of a material with a certain elasticity such as rubber or silicone, so that the first shell 11 and the second shell 12 can seal the standard cavity 301 and the reference cavity 302 respectively by interference fit when clamping the wall assembly 30.

[0045] In one embodiment, the first conduit 310 is formed with a liquid inlet 311, and the second conduit 320 is formed with a liquid outlet 321. The liquid inlet 311 and the liquid outlet 321 are respectively connected to the standard cavity 301. The liquid inlet 311 generally includes a first liquid inlet section 3111 and a second liquid inlet section 3112 that are connected. The first liquid inlet section 3111 is connected to the standard cavity 301, and the second liquid inlet section 3112 is located at the end of the first liquid inlet section 3111 that faces away from the standard cavity 301. The liquid outlet 321 generally includes a first liquid outlet section 3211 and a second liquid outlet section 3212 that are connected. The first liquid outlet section 3211 is connected to the standard cavity 301, and the second liquid outlet section 3212 is located at the end of the first liquid outlet section 3211 that faces away from the standard cavity 301. Preferably, the first liquid inlet hole segment 3111 has a substantially uniform diameter along its axis, while the second liquid inlet hole segment 3112 has a diameter that gradually increases in a direction away from the first liquid inlet hole segment 3111, i.e., the second liquid inlet hole segment 3112 is substantially trumpet-shaped. The first liquid outlet hole segment 3211 has a substantially uniform diameter along its axis, while the second liquid outlet hole segment 3212 has a diameter that gradually increases in a direction away from the first liquid outlet hole segment 3211, i.e., the second liquid outlet hole segment 3212 is substantially trumpet-shaped. It will be appreciated that the trumpet-shaped second liquid inlet hole segment 3112 facilitates docking with an external liquid pipeline.

[0046] See also Figure 6 , Figure 6 Schematic diagram of the structure of the first housing 11 in some embodiments of the present application. The enclosure assembly 30 generally comprises a first enclosure wall 30a and a second enclosure wall 30b. The first enclosure wall 30a abuts against two opposing sides of the cavity 101 to form a standard cavity 301, while the second enclosure wall 30b abuts against the opposing sides of the cavity 101 to form a control cavity 302. A retaining member 150 is provided on at least one of the opposing sides of the cavity 101. The enclosure assembly 30 is sleeved within the retaining member 150 to limit the position of the enclosure assembly 30.

[0047] In the example of a position-limiting member 150 disposed on the wall of the first receiving cavity 11a, the position-limiting member 150 can be a plurality of position-limiting posts protruding from the wall of the first receiving cavity 11a, with the first surrounding wall 30a and the second surrounding wall 30b being mounted on the plurality of position-limiting posts to achieve position limiting. Of course, in other embodiments, the position-limiting member 150 can be a position-limiting wall surrounding the standard cavity 301 and the reference cavity 302, with the position-limiting wall cooperating with the wall of the first receiving cavity 11a to form a position-limiting groove, with the first surrounding wall 30a and the second surrounding wall 30b being embedded in the position-limiting groove to achieve position limiting.

[0048] See also Figure 7 and Figure 8 , Figure 7is another cross-sectional structural diagram of the blood sample analysis module 100 in some embodiments of the present application. Figure 8 Schematic diagram of the structure of the first shell 11 in some other embodiments of the present application. The wall assembly 30 generally includes a first wall 30a and a second wall 30b. The first wall 30a contacts the two opposite sides of the cavity 101 to form a standard cavity 301, and the second wall 30b contacts the two opposite sides of the cavity 101 to form a control cavity 302. At least one of the two opposite sides of the cavity 101 is provided with a first receiving groove 1011 for limiting the first wall 30a, and a second receiving groove 1012 for limiting the second wall 30b. The first wall 30a is at least partially embedded in the first receiving groove 1011, and the second wall 30b is at least partially embedded in the second receiving groove 1012 to prevent the wall assembly 30 from being misaligned during assembly.

[0049] It should be understood that embedding at least a portion of the first and second surrounding walls 30a, 30b within the first and second receiving grooves 1011, 1012, respectively, not only prevents misalignment of the wall assembly 30 during assembly, but also enhances the airtightness of the standard and reference chambers 301, 302, and prevents leakage. The shape of the first receiving groove 1011 is adapted to the outer periphery of the first surrounding wall 30a, while the shape of the second receiving groove 1012 is adapted to the outer periphery of the second surrounding wall 30b.

[0050] In one embodiment, the first surrounding wall 30a and the second surrounding wall 30b are an integral structure, in which case the first receiving groove 1011 and the second receiving groove 1012 are connected. Of course, in other embodiments, the first surrounding wall 30a and the second surrounding wall 30b can be separate independent structures, in which case the first receiving groove 1011 and the second receiving groove 1012 are not connected to each other.

[0051] The first pipe 310 and the second pipe 320 are arranged on the side of the first surrounding wall 30a away from the first accommodating groove 1011 and are respectively connected to the first accommodating groove 1011, so that the first pipe 310 and the second pipe 320 can be connected to the standard cavity 301 through the first accommodating groove 1011.

[0052] Specifically, the bottom wall of the first accommodating tank 1011 is provided with a first fluid groove 1011a communicating with the liquid inlet 311 and a second fluid groove 1011b communicating with the liquid outlet 321. The first fluid groove 1011a is respectively connected to the liquid inlet 311 and the standard cavity 301, and the second fluid groove 1011b is respectively connected to the liquid outlet 321 and the standard cavity 301. In other words, the liquid inlet 311 can be connected to the standard cavity 301 via the first fluid groove 1011a, and the liquid outlet 321 can be connected to the standard cavity 301 via the second fluid groove 1011b. That is, the first pipe 310 can be connected to the standard cavity 301 via the first fluid groove 1011a, and the second pipe 320 can be connected to the standard cavity 301 via the second fluid groove 1011b.

[0053] The first and second surrounding walls 30a, 30b are arranged side by side on the walls of the first receiving cavity 11a. When the first and second shells 11, 12 cooperate to clamp the first and second surrounding walls 30a, the first and second shells 11, 12 cooperate to clamp the first surrounding wall 30a, so that the two opposing surfaces of the first surrounding wall 30a respectively interfere with the first and second shells 11, 12, achieving a sealing effect. The first and second shells 11, 12 cooperate to clamp the second surrounding wall 30b, so that the two opposing surfaces of the second surrounding wall 30b respectively interfere with the first and second shells 11, 12, achieving a sealing effect.

[0054] At the same time, the first pipe 310 and the standard cavity 301 are respectively connected to the first fluid tank 1011a, and the second pipe 320 and the standard cavity 301 are respectively connected to the second fluid tank 1011b, so that the liquid outside the blood sample analysis module 100 can flow into the first fluid tank 1011a through the first pipe 310, and then flow into the standard cavity 301 through the first fluid tank 1011a; and the liquid in the standard cavity 301 can flow into the second pipe 320 through the second fluid tank 1011b, and then flow to the outside of the blood sample analysis module 100 through the second pipe 320.

[0055] As previously mentioned, the third through-hole 130 extends through the wall of the second receiving chamber 11b. Furthermore, the third through-hole 130 extends through the bottom wall of the second receiving groove 1012, allowing the control chamber 302 to communicate with the second receiving chamber 11b via the third through-hole 130. This allows liquid in the second receiving chamber 11b to flow into the control chamber 302 via the third through-hole 130. Preferably, the second surrounding wall 30b surrounds the third through-hole 130 to enhance the sealing effect of the control chamber 302.

[0056] It is understood that when the blood sample analysis module 100 is used in conjunction with a blood gas analysis device, liquids such as test fluid, calibration fluid, and cleaning fluid can flow through the standard cavity 301 to complete the corresponding testing, calibration, and cleaning operations. It is also understood that the second housing 12 can be provided with at least one electrode for performing electrochemical analysis. The electrode can be distributed on the walls of the standard cavity 301 and the control cavity 302. Liquid flowing into the standard cavity 301 and the control cavity 302 covers the electrode, thereby enabling the measurement of parameters such as pH, hematocrit, ion concentration, lactate, and O2 and CO2 partial pressures via the electrical signals from the electrode.

[0057] The blood sample analysis module provided by the present application, before the test liquid measurement is performed, the cleaning liquid and the calibration liquid flow into the standard cavity respectively to complete the cleaning and calibration operations, and after the operation is completed, it flows out of the blood sample analysis module from the standard cavity, and will not be stored inside the blood sample analysis module. The test liquid flows into the standard cavity to complete the parameter measurement, and after the measurement is completed, it flows out of the blood sample analysis module from the standard cavity, and will not be stored inside the blood sample analysis module. The blood sample analysis module provided by the present application does not need to set up a waste liquid recovery container inside the blood sample analysis module, which can greatly reduce the volume of the blood sample analysis module and help to achieve the thinness of the blood sample analysis module. In addition, the test liquid, cleaning liquid and calibration liquid flow through the standard cavity respectively to complete the corresponding operations, and then flow out of the blood sample analysis module from the standard cavity, so that the blood sample analysis module can achieve multiple repeated measurements, which greatly increases the number of measurements of the blood sample analysis module. There is no need to frequently replace the blood sample analysis module, which can further improve the test efficiency.

[0058] See also Figure 9 , Figure 9 is a partial structural diagram of the blood sample analysis module 100 in some embodiments of the present application, wherein: Figure 9 The figure schematically illustrates the coordination of the enclosure assembly 30 and the second housing 12. The first enclosure wall 30a and the second enclosure wall 30b of the enclosure assembly 30 are arranged side by side on the second housing 12, and cooperate with the second housing 12 and the first housing 11 to form a reference cavity 302 for the standard cavity 301. As previously mentioned, the second housing 12 can be a circuit board, on which the first test electrode group 51, the second test electrode group 52, and the third test electrode group 53 are spaced apart.

[0059] The first test electrode group 51 is configured to measure electrochemical parameters of the liquid in the standard chamber 301 , and the second test electrode group 52 is configured to feed back the potential of the first test electrode group 51 to ensure the potential of the first test electrode group 51 is stable.

[0060] Specifically, the first test electrode group 51 may include at least one test electrode, which is exposed on the wall of the standard chamber 301 and is used to obtain electrochemical parameters of the liquid in the standard chamber 301. The second test electrode group 52 may include at least one reference electrode, which is exposed on the wall of the control chamber 302 and is used to obtain electrode potentials. The first test electrode group 51 and the second test electrode group 52 are respectively connected to the third test electrode group 53, so that the acquired signal data can be transmitted to the blood gas analysis equipment for further processing via the third test electrode group 53.

[0061] Based on this, the control cavity 302 is configured to accommodate liquids such as reference solutions, and there is no need to set up additional containers for accommodating liquids such as reference solutions. The overall structure is simple and easy to assemble. Among them, the second shell 12 is also provided with a salt bridge 54 that runs through the standard cavity 301 and the control cavity 302 to reduce the liquid junction potential. It can be understood that a salt bridge is inserted between the two solutions to replace the original direct contact between the two solutions, thereby reducing and stabilizing the liquid junction potential (when two electrolytes with different compositions or activities are in contact, the positive and negative charges are separated at the solution junction due to the different ion migration speeds of positive and negative ions diffusing through the interface and forming a double layer. The potential difference thus generated is called the liquid junction diffusion potential, or liquid junction potential for short), so that the liquid junction potential is minimized to the point of being nearly eliminated. That is, it prevents the ions in the standard cavity 301 from diffusing into the control cavity 302 to affect the potential of the reference electrode. For example, when the reference solution in the control cavity 302 is a saturated KCI solution, its concentration is generally as high as 4.2 mol / dm 3 When a salt bridge is inserted at the interface between two electrolyte solutions of low concentration, two junctions are created. The outward diffusion of K+ and Cl- from the salt bridge becomes the dominant ion diffusion at these two interfaces. Because the diffusion rates of K+ and Cl- are similar, the junction potential generated by the salt bridge in contact with the two solutions is very small and in opposite directions, thus canceling each other out and reducing it to 1-2 mV. The electrolyte in the salt bridge is selected based on high concentration, nearly equal positive and negative ion migration numbers, and no chemical reaction with the liquid in standard chamber 301. Saturated solutions of KCl, NH4NO3, and KNO3 are commonly used as reference solutions.

[0062] That is, by providing the salt bridge 54 through the standard cavity 301 and the reference cavity 302 , it is ensured that the liquids in the standard cavity 301 and the reference cavity 302 are immiscible, thereby reducing the influence on the potential of the reference electrode.

[0063] It is understandable that the second receiving chamber 11b is configured to accommodate a reference solution or a container containing a reference solution, and the reference solution in the second receiving chamber 11b can flow into the control chamber 302 through the third through hole 130, which can increase the number of uses of the blood sample analysis module.

[0064] The blood sample analysis module provided by the present application is formed by setting a wall assembly in the cavity within the shell to form a standard cavity and a control cavity, and by setting a first pipe and a second pipe connecting the standard cavity on the wall assembly, the first pipe is embedded in the first through hole of the shell, and the second pipe is embedded in the second through hole of the shell to connect the inside and outside of the shell, so that the external liquid of the blood sample analysis module can flow into and out of the standard cavity from the first pipe and the second pipe, and the external liquid or the liquid pre-accommodated in the blood sample analysis module can flow into the control cavity from the third through hole. At the same time, the cavity walls of the standard cavity and the control cavity are both provided with electrode assemblies, so that the blood sample analysis module can complete the corresponding measurement operation, and the liquid in the standard cavity will not be stored inside the blood sample analysis module after the measurement is completed, which can greatly reduce the volume of the blood sample analysis module. The liquid in the standard cavity can flow into and out of the blood sample analysis module through the first pipe and the second pipe respectively, so that the blood sample analysis module can achieve multiple repeated measurements, greatly improving the number of measurements of the blood sample analysis module, without the need to frequently replace the blood sample analysis module, and high testing efficiency.

[0065] It should be noted that the terms "include," "comprise," and "have," and any variations thereof, are intended to cover non-exclusive inclusions. For example, a process, method, system, product, or apparatus comprising a series of steps or units is not limited to the listed steps or units, but may optionally include steps or units not listed, or other steps or units inherent to the process, method, product, or apparatus.

[0066] The above descriptions are only some embodiments of the present application and do not limit the scope of protection of the present application. Any equivalent device or equivalent process transformation made using the contents of the description and drawings of this application, or directly or indirectly applied in other related technical fields, are also included in the scope of patent protection of this application.

Claims

1. A blood gas and biochemistry test card, characterized in that: include: a housing, wherein a cavity is provided in the housing; a wall assembly disposed in the cavity, the wall assembly comprising a first wall and a second wall, the first wall abutting against two opposite sides of the cavity to form a standard cavity, the second wall abutting against the two opposite sides of the cavity to form a control cavity, the liquids in the standard cavity and the control cavity being disconnected from each other, the control cavity being configured to accommodate a reference liquid, and the liquid in the standard cavity being able to flow out of the blood gas and biochemistry test card after the measurement is completed and not being stored inside the blood gas and biochemistry test card; An electrode assembly includes a first test electrode group exposed in the standard cavity and a second test electrode group exposed in the control cavity.

2. The blood gas and biochemistry test card according to claim 1, characterized in that: The shell includes a first shell and a second shell arranged on one side of the first shell, the first shell and the second shell cooperate to form the cavity, the first shell and the second shell cooperate to clamp the first surrounding wall and the second surrounding wall, the opposite two sides of the first surrounding wall respectively conflict with the first shell and the second shell to form the standard cavity, and the opposite two sides of the second surrounding wall respectively conflict with the first shell and the second shell to form the control cavity.

3. The blood gas and biochemistry test card according to claim 1, characterized in that: The first surrounding wall is annular and is disposed around the periphery of the first test electrode group so that the first test electrode group is exposed in the standard cavity; and / or, The second surrounding wall is annular and is disposed around the periphery of the second test electrode group so that the second test electrode group is exposed to the control cavity.

4. The blood gas and biochemistry test card according to claim 2, characterized in that: The wall assembly is made of rubber or silicone material, and the first shell and the second shell respectively seal the standard cavity and the reference cavity by interference fit when clamping the wall assembly.

5. The blood gas and biochemistry test card according to any one of claims 1 to 4, characterized in that: The first test electrode group is configured to measure electrochemical parameters of the liquid in the standard chamber, and the second test electrode group is configured to provide feedback on the potential of the first test electrode group to ensure that the potential of the first test electrode group is stable; The first test electrode group includes at least one test electrode, which is exposed on the wall of the standard chamber to obtain electrochemical parameters of the liquid in the standard chamber. The second test electrode group includes at least one reference electrode, which is exposed on the wall of the control chamber to obtain electrode potential.

6. The blood gas and biochemistry test card according to claim 5, characterized in that: The housing includes a first housing and a second housing provided on one side of the first housing, the second housing being a circuit board, the first test electrode group and the second test electrode group being provided on the circuit board at intervals, and the first test electrode group and the second test electrode group being provided on the same side of the circuit board; A third test electrode group is provided on the circuit board, and the third test electrode group and the first test electrode group are provided on the same side of the circuit board, or the third test electrode group and the first test electrode group are provided on opposite sides of the circuit board; The first test electrode group and the second test electrode group are respectively connected to the third test electrode group, so as to send the acquired signal data to the blood gas analysis device via the third test electrode group.

7. The blood gas and biochemistry test card according to any one of claims 1 to 4, characterized in that: The housing is provided with a first through hole and a second through hole, the first through hole and the second through hole are communicated with the standard cavity, and the external liquid of the blood gas and biochemistry test card can flow into and out of the standard cavity through the first through hole and the second through hole.

8. The blood gas and biochemistry test card according to claim 7, characterized in that: The housing is provided with a third through hole, which is communicated with the control cavity. External liquid or liquid pre-contained in the blood gas and biochemistry test card can flow into the control cavity from the third through hole.

9. The blood gas and biochemistry test card according to claim 1, characterized in that: The shell includes a first shell and a second shell provided on one side of the first shell, the first shell and the second shell cooperate to form the cavity, the second shell is a circuit board, the first test electrode group, the second test electrode group and the third test electrode group are arranged on the circuit board at intervals, the first test electrode group and the second test electrode group are provided on the same side of the circuit board, and the third test electrode group and the first test electrode group are provided on the same side of the circuit board; the first test electrode group is configured to measure the electrochemical parameters of the liquid in the standard cavity, and the second test electrode group is configured to feedback the potential of the first test electrode group to ensure the stability of the potential of the first test electrode group; the first test electrode group includes at least one test electrode, the at least one test electrode is exposed on the cavity wall of the standard cavity for obtaining the electrochemical parameters of the liquid in the standard cavity, and the second test electrode group includes at least one reference electrode, the at least one reference electrode is exposed on the cavity wall of the control cavity for obtaining the electrode potential; the first test electrode group and the second test electrode group are respectively connected to the third test electrode group, so as to send the obtained signal data to the blood gas analysis equipment through the third test electrode group; The first shell and the second shell cooperate to clamp the first and second surrounding walls, and opposite sides of the first surrounding wall respectively contact the first and second shells to form the standard cavity, and opposite sides of the second surrounding wall respectively contact the first and second shells to form the control cavity. The first surrounding wall is annular and is arranged around the periphery of the first test electrode group so that the first test electrode group is exposed to the standard cavity. The second surrounding wall is annular and is arranged around the periphery of the second test electrode group so that the second test electrode group is exposed to the control cavity. The wall assembly is made of rubber or silicone material. When the first and second shells clamp the wall assembly, they seal the standard cavity and the control cavity respectively by means of interference fit. The wall assembly is made of rubber or silicone material. When the first and second shells clamp the wall assembly, they seal the standard cavity and the control cavity respectively by means of interference fit. The first and second surrounding walls are an integral structure. The first and second surrounding walls are arranged side by side on the second shell. The second shell is also provided with a salt bridge that passes through the standard cavity and the control cavity. The shell is provided with a first through hole, a second through hole and a third through hole. The first through hole and the second through hole respectively penetrate the second shell to communicate with the standard cavity. External liquid of the blood gas and biochemistry test card can flow into and out of the standard cavity through the first through hole and the second through hole. The third through hole penetrates the first shell and communicates with the control cavity. External liquid or liquid pre-accommodated in the blood gas and biochemistry test card can flow into the control cavity through the third through hole.

10. A blood gas and biochemistry test card, characterized in that: A housing, the housing comprising a first housing and a second housing provided on one side of the first housing, the first housing and the second housing cooperating to form a cavity, the second housing being a circuit board provided with an electrode assembly; a wall assembly, the wall assembly being disposed in the cavity and in contact with the cavity to form a standard cavity and a control cavity, wherein the liquids in the standard cavity and the control cavity are not connected to each other, and the control cavity is configured to accommodate a reference liquid. After the measurement is completed, the liquid in the standard cavity can flow out of the blood gas and biochemistry test card and will not be stored inside the blood gas and biochemistry test card; The walls of the standard cavity and the control cavity are both provided with the electrode assembly, so that the blood gas and biochemistry test card can complete the measurement operation.

11. The blood gas and biochemistry test card according to claim 10, characterized in that: The enclosure assembly includes a first enclosure wall and a second enclosure wall, wherein the first enclosure wall and the second enclosure wall are an integrated structure; The first shell and the second shell cooperate to clamp the first surrounding wall and the second surrounding wall, the opposite sides of the first surrounding wall respectively conflict with the first shell and the second shell to form the standard cavity, and the opposite sides of the second surrounding wall respectively conflict with the first shell and the second shell to form the control cavity.

12. The blood gas and biochemistry test card according to claim 10 or 11, characterized in that: A first test electrode group, a second test electrode group, and a third test electrode group are arranged on the circuit board at intervals, and the first test electrode group and the second test electrode group are arranged on the same side of the circuit board; The third test electrode group and the first test electrode group are arranged on the same side of the circuit board, or the third test electrode group and the first test electrode group are arranged on opposite sides of the circuit board; The first test electrode group and the second test electrode group are respectively connected to the third test electrode group, so that the acquired signal data is sent to the blood gas analysis device for further processing via the third test electrode group.

13. The blood gas and biochemistry test card according to claim 11, characterized in that: The second shell is further provided with a salt bridge running through the standard cavity and the control cavity.

Images