Traditional Chinese medicine composition for treating benign prostatic hyperplasia

Abstract

The invention discloses a traditional Chinese medicine composition for treating benign prostatic hyperplasia, and belongs to the technical field of traditional Chinese medicines. The monarch drug in the traditional Chinese medicine composition is pokeberry root; minister drugs comprise mustard seeds and edible tulip; the adjuvant drugs comprise semen strychni, airpotato yam rhizome and fistular onion stalk; and the conductant drug is coix seed. The whole formula is coordinated by monarch, minister, assistant and guide, is rigorous in formula, and has the effects of tonifying qi and spleen, clearing heat and promoting diuresis, inducing diuresis to reduce edema, counteracting toxic substances and removing stasis. The composition disclosed by the invention is sufficient in medicine source, relatively low in cost, non-invasive, stable in curative effect, convenient to apply and capable of treating prostatic hyperplasia through external application, thereby having a relatively great popularization prospect.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating benign prostatic hyperplasia. Background Art

[0002] Benign prostatic hyperplasia is a common benign disease in middle-aged and elderly men, and its high incidence seriously affects the quality of life of the elderly. Benign prostatic hyperplasia mainly occurs in the transitional zone around the prostatic urethra. The hyperplastic gland causes the prostatic urethra to elongate, bend, be compressed and narrowed, increasing urethral resistance, resulting in difficult urination. In mild cases, there are frequent urination and urgency. When secondary infections occur, there may be painful urination, increased nocturia, shorter urine stream, bifurcation, interrupted urination, long waiting time for urination, incomplete urination, etc. In severe cases, it can lead to urinary incontinence, hydronephrosis, hematuria or acute urinary retention. Many patients may have sexual function decline and varying degrees of impaired renal function.

[0003] So far, the cause of benign prostatic hyperplasia is still unclear in modern medicine. The industry generally believes that the disease may be related to age and hormone levels. At present, the treatment methods for this disease are divided into drug conservative treatment and surgery. For drug conservative treatment, the commonly used drugs are α-receptor blockers, finasteride, and traditional Chinese patent medicines for promoting diuresis and relieving stranguria. Even if the condition of some patients is temporarily relieved, they still need to adhere to the use of drugs for a long time. Since most patients with benign prostatic hyperplasia are middle-aged and elderly men, many patients take multiple drugs simultaneously, such as hypoglycemic drugs, antihypertensive drugs, and lipid-lowering drugs. If new drugs are added to be taken daily, on the one hand, it will increase the economic burden of patients, and on the other hand, it is likely to cause damage to the liver and kidneys and other functions of the elderly. For surgical treatment, its advantage is that the curative effect is definite, but the disadvantages are high surgical cost and large trauma. Since many elderly patients have multiple chronic diseases, the implementation of surgery is often restricted. Therefore, developing new conservative treatment methods for benign prostatic hyperplasia has great practical value. Summary of the Invention

[0004] In view of the above-mentioned prior art, the object of the present invention is to provide a traditional Chinese medicine composition for treating benign prostatic hyperplasia.

[0005] Traditional Chinese medicine believes that benign prostatic hyperplasia belongs to the category of "retention of urine" in traditional Chinese medicine: "Retention of urine with slow and scanty urination" means difficult urination with small amounts of urine dripping, and the condition is relatively mild; "Retention of urine with complete urinary retention" means the inability to urinate at all, and the disease situation is more urgent and requires emergency treatment. The basic cause of this disease is the deficiency of the liver and kidneys, and the decline of the bladder's qi transformation and fixation functions. The basic pathogenesis is the mutual binding of phlegm and stasis, and the downward flow of damp-heat. The inventor believes that the general treatment principle is to clear heat and promote diuresis, resolve phlegm and disperse stasis; then, the inventor developed a traditional Chinese medicine composition for treating benign prostatic hyperplasia, which has the advantages of sufficient drug sources, low cost, no trauma, and convenient application. After clinical tests, the curative effect of this medicine is stable. Most patients' symptoms are alleviated after one week of taking the medicine, and after continuous application for two months, 80% of the clinical symptoms can disappear or be significantly improved.

[0006] To achieve the above object, the present invention adopts the following technical solutions:

[0007] The first aspect of the present invention provides a traditional Chinese medicine composition for treating benign prostatic hyperplasia, which comprises the following raw materials in parts by weight: 13-17 parts of pokeweed, 7-11 parts of mustard seeds, 4-8 parts of trillium, 1-5 parts of strychnine seeds, 8-12 parts of radix polygoni bulgurii, 40-60 parts of scallion whites and 18-22 parts of coix seeds.

[0008] The present invention is solved as follows:

[0009] Phytolacca is the monarch herb. Phytolacca is bitter, cold, and toxic. Its effects include diuresis, reduced swelling, and facilitating bowel movements. Externally, it can detoxify and resolve stagnation. This bitter and cold herb has a purging effect, promoting bowel movements and eliminating dampness. Therefore, it can treat edema, constipation, and dysuria. The ancients said, "Phytolacca moves water with the force of a mountain and an overturning sea." Externally, Phytolacca has excellent detoxifying and stagnation-relieving properties, earning it the monarch herb.

[0010] Mustard seeds and Trillium gracile are both adjuvants. Mustard seeds have a pungent and warm nature. Efficacy: Warms the lungs and dissipates phlegm, promotes qi and resolves stagnation, dredges the meridians and relieves pain. This herb is pungent, warm, and potent, with a dispersing nature. It can warm and dredge the meridians, effectively dispersing "phlegm trapped inside the skin and membranes," and can also reduce swelling, resolve stagnation, and relieve pain. "Pharmaceutical Chemistry" states: "White mustard...moves very quickly...passes very sharply, specifically dispersing phlegm, dissolving heat-related phlegm and dispersing cold-related phlegm. Phlegm trapped outside the skin and membranes cannot be reached without this herb." Trillium gracile has a sweet, slightly pungent, and cooling nature. Efficacy: Clears heat and detoxifies, resolves phlegm and resolves stagnation. This product is pungent and dispersing, cool and heat-clearing, so it has the effects of clearing away heat and detoxifying, resolving phlegm, eliminating carbuncle and dispersing nodules. In recent years, it has been widely used in the treatment of lumps and masses and various benign and malignant tumors, and has always achieved good results. Modern pharmacological research has confirmed that this product has the effects of anti-pathogenic microorganisms, anti-tumor, lowering blood pressure, activating tyrosinase, etc., and is used as a minister together with mustard.

[0011] Strychnos nux vomica, Dioscorea bulbifera, and scallion white are all adjuvants. Strychnos nux vomica has a pungent and warm nature and is highly toxic. It clears the meridians and relieves pain, dispersing stagnation and reducing swelling. This herb has a good circulation and analgesic properties, and is particularly effective for dribbling and painful urination. Its bitter flavor is laxative, dispersing stagnation and reducing swelling, and it has a strong anti-toxic effect, but care should be taken with the dosage and timing of use. Dioscorea bulbifera has a bitter and cold nature and is toxic. This herb has a bitter and cold laxative effect, clearing heat and resolving phlegm, softening and dispersing stagnation. Modern research has confirmed its strong inhibitory effect on tumors and proliferating cells. Its bitter and cold properties penetrate the blood, cooling blood, reducing fire and detoxifying, and treating sores, ulcers, and swelling. scallion white has a pungent and warm nature. It induces sweating, relieves exterior symptoms, dispels cold, and promotes yang. This herb has a pungent, dispersing, warming, and promoting the flow of yang energy, warming and dispersing cold, allowing yang energy to flow smoothly upward and downward, and allowing for smooth internal and external circulation. Crushed and applied externally to the navel, it can treat urinary obstruction caused by bladder qi deficiency, detoxify, disperse stagnation, and unclog the meridians. Its juice can also be used as an adhesive. Rich in capsaicinoids and other substances, it possesses a powerful antiseptic effect. It stimulates the sweat glands and prostate during sweating or urination, thereby sterilizing and enhancing excretion. It is used as an adjuvant alongside Nux vomica and Dioscorea bulbifera.

[0012] Coix seed is the guiding ingredient. Its medicinal properties are sweet, mild, and cooling. Its effects include promoting diuresis and dispelling dampness, strengthening the spleen and arresting diarrhea, dispelling numbness and pus, and detoxifying and dispersing nodules. This product, with its mild, diuretic, and sweet tonic properties, not only promotes diuresis and reduces swelling, but also strengthens the spleen and replenishes the middle qi, tonifying the middle qi while also providing a refreshing effect. The spleen is the foundation of acquired constitution and the source of qi and blood production. For elderly people with qi deficiency and kidney deficiency, this product can not only address both the symptoms and the root cause, but also balance the pungent, warm, and dry properties of other herbs. It can dispel dampness and numbness, clear heat and dampness, and detoxify and resolve nodules. It is used for proliferative diseases such as warts and cancer.

[0013] Furthermore, the Chinese medicine composition comprises the following raw materials in parts by weight: 15 parts of pokeweed, 9 parts of mustard seeds, 6 parts of trillium, 3 parts of strychnine seeds, 10 parts of dioscorea bulbifera, 50 parts of scallion whites and 20 parts of coix seeds.

[0014] The second aspect of the present invention provides the use of the traditional Chinese medicine composition in the preparation of a medicament for treating benign prostatic hyperplasia.

[0015] The third aspect of the present invention provides a drug for treating benign prostatic hyperplasia, wherein the drug uses the traditional Chinese medicine composition as an active ingredient.

[0016] Furthermore, the drug may also include pharmaceutically acceptable excipients.

[0017] Furthermore, the dosage form of the drug is powder, ointment or aqueous solution.

[0018] According to the raw material ratio of the traditional Chinese medicine composition, the medicines except the scallion white are taken and ground into fine powder to obtain the medicine powder; fresh scallions are taken, cleaned and roots are removed, the scallion white is selected and crushed, and the medicine powder is added according to the raw material ratio to obtain the medicine for treating benign prostatic hyperplasia.

[0019] Furthermore, the mixture is ground into a fine powder and then sieved through a sieve with a mesh size of 50-200.

[0020] Furthermore, the frequency of external application is 1-2 hours each time, 1-3 times a day.

[0021] Beneficial effects of the present invention:

[0022] 1. The present invention provides a traditional Chinese medicine composition for treating benign prostatic hyperplasia (BPH) based on the "monarch, minister, assistant, and envoy" compatibility method. The composition comprises Phytolacca scabra (Phytolacca sphaerocarpa) as the monarch ingredient; Mustard seeds and Psoralea corylifolia as the minister ingredients; Strychnos nux vomica (Strychnos nux vomica), Dioscorea bulbifera (Dioscorea bulbifera), and Scallion white (Scallion white) as the adjuvant ingredients; and Coix lachryma-jobi (Coix seed) as the envoy ingredient. The monarch, minister, assistant, and envoy ingredients work together in a rigorous formulation, achieving the effects of tonifying qi and strengthening the spleen, clearing heat and dampness, promoting diuresis and reducing swelling, and combating toxins and dispersing stagnation.

[0023] 2. Through repeated clinical research and verification, the present invention has summarized a complete use scheme for treating benign prostatic hyperplasia based on the above-mentioned traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the present invention is used in an external application manner, which is of great significance for the treatment of benign prostatic hyperplasia. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is the initial diagnosis report of patient 1 in our hospital.

[0025] Figure 2 This is the follow-up report for patient 1 in our hospital.

[0026] Figure 3 This is the initial diagnosis report of patient 2 in our hospital.

[0027] Figure 4 This is the follow-up report for patient 2 in our hospital.

[0028] Figure 5 Diagnosis report of patient 3 from Jinan Eighth People's Hospital.

[0029] Figure 6 This is the follow-up report for patient 3 in our hospital. DETAILED DESCRIPTION

[0030] It should be noted that the following detailed descriptions are illustrative and intended to provide further explanation of the present application. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which the present application belongs.

[0031] In order to enable those skilled in the art to more clearly understand the technical solution of the present application, the technical solution of the present application will be described in detail below with reference to specific embodiments.

[0032] The experimental materials used in the examples of the present invention but not specifically described are all conventional experimental materials in the art and can be purchased through commercial channels.

[0033] Example 1: Chinese medicine composition and its preparation and use method

[0034] 1. Composition of Chinese medicine composition

[0035] 15g of Phytolacca japonica, 9g of mustard seeds, 6g of Trillium gracile, 3g of Strychnos nux vomica, 10g of Dioscorea bulbifera, 50g of scallion white, and 20g of Coix seed.

[0036] 2. Preparation Method

[0037] According to the proportion, take all the medicines except the scallion white, grind them into fine powder, pass through a 100-mesh sieve, and set aside.

[0038] 3. Usage

[0039] Take fresh green onions, wash and remove the roots, select the white part of the green onion and mash it, add 10 ml of the pulp from the green onion leaves, add the powder prepared in step 2 according to the proportion of the raw materials in the composition of step 1, add room temperature boiled water according to the consistency, stir into a paste, divide it into two parts, spread it evenly on the medical mask, and apply it from the navel to the pubic symphysis for 1.5 hours each time, twice a day.

[0040] Example 2: Chinese medicine composition and its preparation and use method

[0041] 1. Composition of Chinese medicine composition

[0042] 17g of Phytolacca japonica, 11g of mustard seeds, 8g of Trillium gracile, 5g of Strychnos nux vomica, 12g of Dioscorea bulbifera, 60g of scallion white, and 22g of Coix seed.

[0043] 2. Preparation Method

[0044] The preparation method of the medicine is the same as that in Example 1.

[0045] 3. Usage

[0046] The method of using the medicine is the same as in Example 1.

[0047] Example 3: Chinese medicine composition and its preparation and use method

[0048] 1. Composition of Chinese medicine composition:

[0049] 13g of Phytolacca japonica, 7g of mustard seeds, 4g of Trillium, 1g of Strychnos nux vomica, 8g of Dioscorea bulbifera, 40g of scallion white, and 18g of Coix seed.

[0050] 2. Preparation Method

[0051] The preparation method of the medicine is the same as that in Example 1.

[0052] 3. Usage

[0053] The method of using the medicine is the same as in Example 1.

[0054] Example 4: Clinical Experimental Effect Verification

[0055] 1. Patient 1

[0056] Wang Moumou, male, 66 years old. Date of consultation: October 6, 2024. Chief complaint: dysuria for two weeks, aggravated for 3 days. Current medical history: The patient had dysuria two weeks ago without obvious cause, and the urine stream became shorter but was not treated. Past medical history: history of kidney stones. Physical examination: elderly male, normal development, good spirits, pale tongue with white fur, and slippery pulse. Color Doppler ultrasound showed: fatty liver (mild); bilateral kidney stones; prostate hyperplasia, prostate size is about 5.6×4.4×4.6cm. Examination report see Figure 1 .

[0057] Diagnosis: Urinary retention - syndrome of spleen deficiency and phlegm obstruction.

[0058] Treatment: The patient was treated with the Chinese medicine formula of Example 1 for one week, and the symptoms were significantly relieved. After two consecutive months of treatment, the patient was re-examined on December 29, 2024. The prostate size was about 5.0×3.8×3.9 cm, and the clinical symptoms disappeared. Figure 2 .

[0059] 2. Patient 2

[0060] Mr. Zhao, male, 83 years old. Chief complaint: frequent urination at night, difficulty urinating for more than 20 years, painful urination, and urinary incontinence for several weeks. Current medical history: The patient has progressively worsened frequent urination, difficulty defecation, frequent urination at night, bifurcated urine for more than 20 years, and urinary incontinence in the past three weeks. Provincial and municipal hospitals both recommended surgery, but due to his advanced age, his children and he did not agree. Past history: More than 20 years ago, an ultrasound examination at Laiwu Hospital of Xinkuang Group diagnosed prostate hyperplasia and calcification (the original report was lost), and a history of coronary heart disease for more than 10 years. Personal history: No bad habits, occasionally drinks a small amount of alcohol. The tongue is dark purple with petechiae, the tongue coating is white and greasy, and the pulse is thin and stringy. Color ultrasound shows: the bladder wall is rough, suspected cystitis; prostate hyperplasia, the prostate size is about 6.0×4.5×4.8cm. See the examination report Figure 3 .

[0061] Diagnosis: Urinary retention - syndrome of phlegm and blood stasis, and weak kidney qi.

[0062] Treatment: The patient was treated with the Chinese medicine formula of Example 1 for more than 10 days, and the symptoms were significantly alleviated. After 4 consecutive months of treatment, the patient was re-examined on November 13, 2024. The prostate size was about 5.5×4.6×4.4cm, and the clinical symptoms had basically disappeared. Figure 4 .

[0063] 3. Patient 3

[0064] Mr. Li, male, 58 years old. Chief complaint: urinary incontinence for more than a month, aggravated for 5 days. Current medical history: The patient had urinary incontinence and shorter urine stream without obvious cause one month ago and came for treatment. Past medical history: healthy. Pale tongue with white fur, deep and thin pulse. Provided color Doppler ultrasound examination of Jinan Eighth People's Hospital, the results showed: right kidney cyst, bilateral kidney stones, prostate hyperplasia, strong echo in the prostate, stones cannot be ruled out, prostate size is about 5.5×3.4×3.7cm. Examination report see Figure 5 .

[0065] Diagnosis: Urinary retention - liver and kidney deficiency syndrome.

[0066] Treatment: The patient was treated with the Chinese medicine formula of Example 1 for one week, and the symptoms were significantly relieved. After 5 consecutive months of treatment, the prostate size was about 4.5×3.2×3.0cm on September 24, 2024, and the clinical symptoms disappeared. Figure 6 .

[0067] The above description is merely a preferred embodiment of the present application and is not intended to limit the present application. Various modifications and variations are possible for those skilled in the art. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present application shall be included within the scope of protection of the present application.

Claims

1. A Chinese medicine composition for treating benign prostatic hyperplasia, characterized in that: The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 13-17 parts of pokeweed, 7-11 parts of mustard seeds, 4-8 parts of trillium, 1-5 parts of strychnine seeds, 8-12 parts of radix polygoni bulgurii, 40-60 parts of scallion whites and 18-22 parts of coix seeds.

2. The Chinese medicine composition according to claim 1, characterized in that The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15 parts of pokeweed, 9 parts of mustard seeds, 6 parts of trillium, 3 parts of strychnine seeds, 10 parts of radix polygoni bulgurii, 50 parts of scallion whites and 20 parts of coix seeds.

3. Use of the Chinese medicine composition according to claim 1 or 2 in the preparation of a medicament for treating benign prostatic hyperplasia.

4. A drug for treating benign prostatic hyperplasia, characterized in that: The medicine uses the traditional Chinese medicine composition according to claim 1 or 2 as an active ingredient.

5. The drug according to claim 4, characterized in that The drug may further include pharmaceutically acceptable excipients.

6. The drug according to claim 4, characterized in that The dosage form of the medicine is powder, ointment or aqueous solution.

7. The drug according to claim 6, characterized in that The preparation method of the drug comprises the following steps: According to the raw material ratio of the Chinese medicine composition of claim 1 or 2, take the medicine except the scallion white, grind them into fine powder, and obtain the medicine powder; take fresh scallion, wash and remove the roots, select the scallion white, crush it, and add the medicine powder according to the raw material ratio to obtain the medicine for treating prostate hyperplasia.

8. The drug according to claim 7, characterized in that Grind together into a fine powder and sieve it with a sieve size of 50-200 mesh.

9. The drug according to claim 7, characterized in that The frequency of external application is 1-2 hours each time, 1-3 times a day.

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