Traditional Chinese medicine water extract mixture for treating gout

Abstract

The invention relates to a medicine, in particular to a medicine for treating gout, and provides a traditional Chinese medicine aqueous extract mixture for treating gout in order to overcome the defects of the existing treatment means. In order to solve the technical problems, the technical scheme adopted by the invention is as follows: 12 traditional Chinese medicines such as salvia miltiorrhiza and the like are taken as main raw materials, an aqueous extract with the highest body utilization rate is mixed with algae-derived astaxanthin, and the vitality of cells and tissues, particularly the uric acid metabolism capability of the kidney, is enhanced by taking liver soothing, spleen strengthening and kidney strengthening as concepts, so that a solution is provided for gout from the source. The traditional Chinese medicine composition has the effective effects that the symptoms can be stabilized and the cascade reaction of inflammation can be obviously relieved when the traditional Chinese medicine composition is taken in an acute stage, and the symptoms basically disappear or are relieved in 3 days generally. And along with the prolonging of the taking time, the feeling of joint stabbing pain disappears, the discomfort of waist pain disappears, the urination is comfortable, the sleep quality becomes good, and the mental state becomes good.

Description

Technical field:

[0001] The present invention relates to a medicine, in particular to a medicine for treating gout. Background technology:

[0002] 1. Causes of gout

[0003] Gout is a severe inflammatory disease caused by hyperuricemia and involving the body's own immune cells.

[0004] Hyperuricemia generally consists of three types: excessive uric acid production, insufficient excretion, or a combination of both. Excretion disorders are the primary cause of hyperuricemia in Chinese patients, accounting for approximately 90% of all cases.

[0005] Traditional diagnosis and treatment focuses on reducing inflammation and relieving pain, clearing away heat and toxins, promoting blood circulation, or dispelling wind and dampness. This lack of consideration for the overall conditioning of the spleen, liver, and kidneys is a major problem. Treatments solely aimed at lowering uric acid levels can only treat the symptoms, not the root cause.

[0006] 2. Current treatment methods and their shortcomings

[0007] Inhibiting uric acid synthesis cannot promote excretion; while promoting excretion cannot inhibit synthesis, but it has no health-preserving effect on the spleen, liver, and kidneys. Summary of the invention:

[0008] In order to overcome the shortcomings of existing treatment methods, the present invention provides a mixture of traditional Chinese medicine water extracts for treating gout.

[0009] The technical solution adopted by the present invention to solve the technical problem is: to soothe the liver, strengthen the spleen, strengthen the kidneys, eliminate inflammation, protect the kidneys, and restore the metabolic function of uric acid.

[0010] Features of the present invention:

[0011] Starting from the root cause of gout, in order to regulate the metabolism of uric acid in the human body and restore the normal excretion function of the kidneys, and based on the latest modern scientific concepts, the unique effects of traditional Chinese medicine, human physiological characteristics, cytology, microbiology, pharmacological safety and other comprehensive considerations, through nearly three decades of experience and exploration, a relatively mature and completely curative formula has been developed. This is the feature, characteristic and specialty of this invention.

[0012] 1. Drug composition and ratio

[0013] 1. 100g of astaxanthin with a purity of 1%.

[0014] 2. 400g plantain.

[0015] 3. 300g of Euonymus fortunei.

[0016] 4. 300g of Eucommia ulmoides.

[0017] 5. 300g dried tangerine peel.

[0018] 6. Salvia miltiorrhiza 200g.

[0019] 7. 60g of Clematis chinensis.

[0020] 8. Ten major merits 60g.

[0021] 9. 60g of dandelion.

[0022] 10. Sheep’s hoof (rhubarb) 60g.

[0023] 11. Houttuynia cordata 60g.

[0024] 12. 60g of turmeric.

[0025] 13. 50g of wild yam.

[0026] 2. Preparation method and process flow

[0027] 1. Primary processing of Chinese medicine - weighing - soaking in water - boiling - decocting - filtering - concentration (drying) - crushing - mixing with astaxanthin - fully mixing - sealing (cool and away from light) - finished product

[0028] 2. Operation

[0029] Roughly process the above-mentioned Chinese herbs (all collected from the wild) (cut into short or small pieces) and place them in a stainless steel pot. Add tap water to cover the herbs, bring to a boil over high heat, then simmer for 20 minutes. Cool and collect the liquid. Concentrate at 100°C and completely dry at 60°C. Grind the dried material into a fine powder. Take 38g of the above-mentioned dried powder (water extract) and thoroughly mix it with astaxanthin.

[0030] 3. Usage and Dosage

[0031] Take 1g-2g daily, swallow twice a day in the morning and evening, and drink plenty of cold boiled water or light tea.

[0032] During an acute gout attack, the dosage can be increased appropriately. It's best to add baking soda to your diet after a meal (alcohol intake) or after a meal high in purine, fructose, or fat. Consume more vitamin C foods when you're overly tired, working up late, or feeling stressed. Soaking your feet in hot water every night before bed is also important.

[0033] 4. Pharmacology and Function

[0034] 1. Astaxanthin

[0035] L-trans astaxanthin from Haematococcus pluvialis is known as one of the most powerful natural antioxidants discovered to date and is easily available on the market.

[0036] Mitochondria are the body's "energy factories," and the process of producing energy also produces large numbers of free radicals. Furthermore, food additives, medications, environmental pollution, and unhealthy lifestyle habits can also generate large numbers of free radicals. When these free radicals exceed the body's ability to process them, they directly damage the mitochondria, starving them of energy, leading to decreased cell and tissue function and inflammation.

[0037] Cell apoptosis plus excessive oxygen free radicals will accelerate the oxidation of deoxyribonucleic acid, which will lead to a large increase in purine. This is why 80% of uric acid comes from endogenous sources.

[0038] In addition, mitochondrial dysfunction due to free radicals and oxidative stress can lead to damage of renal tubular epithelial cells, which are responsible for uric acid reabsorption and distribution of uric acid transporters, and are involved in the occurrence and development of kidney diseases.

[0039] Antioxidant, that is, anti-inflammatory. Compared with anthocyanins, it is a generation away from being better.

[0040] 2. Plantain

[0041] Efficacy: Clears heat, promotes diuresis, relieves stranguria, cools blood and detoxifies.

[0042] Modern pharmacological studies have shown that it can inhibit the activity of URAT1, mRAN, and xanthine oxidase.

[0043] Allopurinol and febuxostat can only selectively inhibit xanthine oxidase and have significant side effects. Although the latter is small, its toxic side effects on cardiovascular diseases, especially the heart, cannot be underestimated.

[0044] URAT1 (uric acid transporter 1) is still the most valuable target for lowering uric acid, and the representative drug benzbromarone also causes considerable damage to the liver.

[0045] The safety and advantages of traditional Chinese medicine are irreplaceable, especially for patients with hypertension, plantain is more like tailor-made.

[0046] 3. Fu Fang Teng

[0047] Efficacy: replenishes Qi and blood, nourishes the liver and kidneys, relaxes muscles and tendons, and has obvious sedative, analgesic and anticoagulant effects.

[0048] It is especially suitable for the acute stage of gout. It is also a rare Chinese medicine of the genus Eriobotrya that can nourish both the liver and kidneys, and has a good analgesic effect.

[0049] 4. Eucommia ulmoides

[0050] Efficacy: Nourishes the liver and kidneys, strengthens the bones and muscles.

[0051] The chlorogenic acid contained in it inhibits the NF-KB and JAK-STAT signaling pathways.

[0052] As a typical inflammatory pathway, NF-KB activation will continuously stimulate the expression of inflammatory cytokines TNF-a and IL-1β, causing an inflammatory response.

[0053] The JAK-STAT signaling pathway is a common pathway for the strong signaling of numerous cytokines. It may regulate the delivery of several important pro-inflammatory cytokines into cells. JAK1 inhibitors can potentially control acute gout attacks anytime, anywhere.

[0054] 5. Tangerine peel

[0055] Efficacy: Strengthens the spleen and appetite, dries dampness and resolves phlegm.

[0056] The potassium citrate it contains can alkaline urine, and the increase in pH value is conducive to the dissolution of uric acid in urine. Potassium supplementation can avoid or slow down the potassium excretion effect of plantain, houttuynia cordata, salvia miltiorrhiza, and sheep's foot.

[0057] 6. Salvia miltiorrhiza

[0058] Efficacy: Promote blood circulation and remove blood stasis, regulate menstruation and relieve pain, clear the heart and relieve restlessness, cool blood and eliminate carbuncle.

[0059] Modern pharmacological research shows that Danshen not only has anticoagulant effects, improves microcirculation, and increases renal cortical blood flow, but also regulates metabolism, immunity, and the nervous system. It promotes tissue repair and regeneration, scavenges free radicals, and promotes kidney function recovery and vitality. It also has beneficial effects on the heart, liver, kidneys, and lungs.

[0060] For gout, Danshen can clear immune complexes and intervene in inflammatory factors, and the cryptotanshinone it contains can target JAK-STAT.

[0061] Immune complexes, especially immunoglobulins, can trigger gout attacks even if uric acid is not high.

[0062] 7. Clematis

[0063] Efficacy: Relieve rheumatism, promote blood circulation and activate collaterals.

[0064] It is related to reducing the deposition of uric acid crystals and inflammatory cell infiltration in the renal tubulointerstitium and downregulating the expression of MCP-1.

[0065] MCP-1: monocyte chemoattractant factor.

[0066] 8. Ten major achievements

[0067] Efficacy: Clears away dryness and dampness, relieves heat and detoxifies.

[0068] Berberine is its main active ingredient, which inhibits the NF-KB signaling pathway, suppresses the production of inflammatory cytokines IL-1β, IL-6, and TNF-a, suppresses acute inflammatory responses, and reduces the polarization of pro-inflammatory M1 macrophages.

[0069] Berberine, chlorogenic acid and rhein can increase the number of lactobacilli.

[0070] Modern microbial research has found that lactobacilli can effectively metabolize uric acid and inhibit IL-1β, IL-6, TNF-a and NF-KB.

[0071] 9. Dandelion

[0072] Efficacy: Clears away heat and detoxifies, eliminates carbuncle and disperses nodules, promotes diuresis and relieves stranguria.

[0073] Dandelion protects against liver damage and enhances regeneration. A healthy liver means stronger kidneys.

[0074] 10. Sheep's Feet (Rhubarb)

[0075] Efficacy: Cooling blood and stopping bleeding, detoxifying and killing parasites, and purging.

[0076] It can detoxify and inhibit uric acid, and has a strong competitive inhibitory effect on xanthine oxidase, inhibiting glomerular sclerosis and renal fiber enhancement.

[0077] The rhein contained in it mediates the transformation of macrophages from pro-inflammatory M1 to anti-inflammatory M2 phenotype, reduces inflammatory factors such as IL-1β, IL-6, and TWT-a, and reduces the infiltration of macrophages in damaged cells.

[0078] Increase the production of Lactobacillus fermentation products to indirectly regulate intestinal purine metabolism and reduce uric acid levels.

[0079] 11. Houttuynia cordata

[0080] Efficacy: Clears away heat and detoxifies, eliminates carbuncle and discharges pus, and promotes diuresis and relieves stranguria.

[0081] It has a good diuretic effect, can speed up blood flow, promote the excretion of uric acid in the body, and relieve pain symptoms.

[0082] 12. Turmeric

[0083] Efficacy: Promotes blood circulation, qi circulation, menstruation regulation and pain relief.

[0084] It has the effects of lowering uric acid, inhibiting xanthine oxidase activity, and enhancing urinary uric acid excretion.

[0085] Its main active ingredient, curcumin, promotes dendritic cells (DC) to produce IL-10, induces the differentiation of CD4+CD 25+ forkhead transcription factor (FOX) P3+Treg, and regulates the balance of Th17.

[0086] Inhibit the production of reactive oxygen species and the release of tissue enzyme B, reduce caspase-1, IL-1β and the expression of apoptosis-associated protein (ASC), thereby inhibiting the activation of NLRP3 inflammasome.

[0087] Inhibit the NF-KB signaling pathway.

[0088] Inhibits the MCP-1 / CCR2 signaling pathway.

[0089] NLRP3 inflammasome is an important pathway for IL-1β to exert its effects, initiating and activating NF-KB.

[0090] The above mechanism indicates that it has a strong anti-inflammatory effect.

[0091] 13. Smilax glabra

[0092] Efficacy: An important medicine for clearing joints, detoxifying and removing dampness.

[0093] It inhibits xanthine oxidase and reabsorption of uric acid by the renal tubules, and its effect is even stronger than that of benzbromarone.

[0094] Inhibit NLRP3 activation and reduce the expression of downstream IL-1β, IL-6, and TNF to inhibit the inflammatory response.

[0095] 5. Comply with the scientific and safe use of medication.

[0096] Traditional Chinese medicine believes that gout is rooted in the spleen and kidneys. The spleen controls dampness, and the liver and kidneys have the same origin. As long as all three are strong, gout can be eradicated.

[0097] In the treatment of gout, the kidney's function of metabolizing and excreting uric acid is very important and particularly critical, because two-thirds of the body's uric acid is excreted through the kidneys, and only one-third is excreted through the intestines (the balance or health of the flora is also very important, which will not be elaborated here).

[0098] Any Chinese herbal remedies for kidney strengthening and nourishment must avoid those that enhance or restore the immune system, such as those that target aggressive T cells, natural killer (NK) cells, antibody-producing B cells, and the IL-2 that stimulates their function. Otherwise, they will only exacerbate and delay the onset of the disease, ultimately working in the opposite direction. Therefore, Eucommia ulmoides is an excellent choice for kidney strengthening and tonification in gout sufferers.

[0099] After all, Chinese medicine is still medicine, and a single Chinese herb is a large compound. Given the carcinogenicity, hepatotoxicity, and nephrotoxicity of some compounds, avoiding secondary harm to patients is a primary consideration in this invention. Here, the dosage of Clematis chinensis, Smilax glabra, and Rhizoma Clematidis, which are overly potent or questionable in nature and flavor, is limited, striving to achieve greater efficiency and safety.

[0100] 6. Conclusion

[0101] The use of the drugs of the present invention can achieve the effects of soothing the liver, strengthening the spleen and strengthening the kidneys. It can control excessive production and solve the problem of reduced excretion; it can eliminate inflammation and pain, and regulate the whole body, and restore and protect kidney function.

[0102] The effective effects of the present invention are: treating the symptoms in an emergency - reducing inflammation and relieving pain; treating the root cause in a slow manner - reducing uric acid, protecting the kidneys, and restoring their uric acid metabolism function.

[0103] Specific implementation methods: Further improve each node, strive for standardized operation, and ultimately form a mature drug to provide patients with more ideal services.

Claims

1. A mixture of Chinese herbal aqueous extracts for treating gout, comprising: Contains 1% astaxanthin, plantain, eucommia bark, tangerine peel, salvia miltiorrhiza, clematis root, mahonia, dandelion, rhubarb, houttuynia cordata, turmeric, and wild yam.

2. The astaxanthin with a content of 1% according to claim 1, wherein the astaxanthin used is 1% in a dosage of 100 g.

3. The plantain according to claim 1, used in an amount of 400g.

4. The Euonymus fortunei of claim 1, wherein the amount used is 300 g.

5. The Eucommia ulmoides according to claim 1, used in an amount of 300g.

6. dried orange peel according to claim 1, usage amount is 300g.

7. The salvia miltiorrhiza according to claim 1, used in an amount of 200g.

8. The Clematis chinensis according to claim 1, used in an amount of 60g.

9. The magnolia ternata according to claim 1, wherein the usage amount is 60g.

10. The dandelion according to claim 1, used in an amount of 60 g.

11. The Rhizoma Rhei (Rheum officinale) according to claim 1, used in an amount of 60g.

12. The herb Houttuynia cordata according to claim 1, used in an amount of 60 g.

13. The turmeric according to claim 1, used in an amount of 60 g. The Rhizoma Smilacis Glabrae according to claim 1 , used in an amount of 50 g.