Valve unit for chromatography system

Abstract

The invention relates to the technical field of separation and purification systems, in particular to a valve unit for a chromatographic system, which comprises a sample inlet and a sample outlet, the sample inlet and the sample outlet are connected through a pipeline, and a first chromatographic column and a second chromatographic column are arranged on the pipeline between the sample inlet and the sample outlet; the flow path guiding assembly is used for responding to a control signal so as to guide a sample to flow in the valve unit, and under the action of the flow path guiding assembly, when the sample needs to flow through the first chromatographic column and the second chromatographic column in an indefinite sequence mode, the flowing directions of the sample in the first chromatographic column and the second chromatographic column are the same. According to the method and the device, the operation convenience in the continuous chromatography execution process is improved, so that the execution efficiency of the continuous chromatography is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of separation and purification systems, in particular to a valve unit for a chromatography system. Background Art

[0002] Chromatography, also known as chromatography or chromatographic method, is a physical and chemical separation method that uses the solubility, adsorption and other properties of substances. Its separation principle is based on the difference in the interaction between the components of the mixture in two immiscible phases (called stationary phase and mobile phase).

[0003] In continuous chromatography, two or more identical chromatography columns are connected in a certain arrangement, and all chromatography columns can be run substantially simultaneously, but in different stages. This procedure can be repeated so that each chromatography column is loaded / filled, eluted, and regenerated several times during the process. Compared to conventional chromatography (where a single chromatography cycle is based on several consecutive steps, such as loading, washing, elution, and regeneration), in continuous chromatography based on multiple identical columns, all these steps are performed simultaneously, but on different chromatography columns.

[0004] However, in the existing execution process, the existing valve unit is generally unable to support the switching of forward and reverse flow between the two chromatography columns and the series use of the two chromatography columns, which makes the operation of the execution process more complicated and easily leads to low efficiency of the execution process. Summary of the Invention

[0005] In order to improve the operational convenience during the execution of continuous chromatography, thereby improving the execution efficiency of continuous chromatography, the present application provides a valve unit for a chromatography system.

[0006] The present application provides a valve unit for a chromatography system, which adopts the following technical solution: A valve unit for a chromatography system comprises a sample inlet and a sample outlet, wherein the sample inlet and the sample outlet are connected by a pipeline, and a first chromatography column and a second chromatography column are provided on the pipeline between the sample inlet and the sample outlet; and further comprises a flow path guiding component, wherein the flow path guiding component is used to respond to a control signal and thereby guide the flow of the sample in the valve unit, and under the action of the flow path guiding component, when the sample needs to flow through the first chromatography column and the second chromatography column in an unsequential manner, the flow direction of the sample in the first chromatography column and the second chromatography column is the same.

[0007] By adopting the above technical solution, the flow path guiding component is used to help guide the flow path of the sample inside the valve unit, thereby helping to guide the sample to flow through the first chromatographic column or the second chromatographic column or the first chromatographic column and the second chromatographic column according to the set flow path, helping to prevent the execution process of continuous chromatography from being interrupted, thereby helping to improve the continuity and convenience of operations during the execution process of continuous chromatography, and further helping to improve the execution efficiency of continuous chromatography.

[0008] In a specific embodiment, the first chromatographic column has a first proximal end and a first distal end, the first proximal end is an end of the first chromatographic column close to the sample inlet, the first distal end is an end of the first chromatographic column away from the sample inlet, and the direction from the first proximal end toward the first distal end is the forward direction, and the direction from the first distal end toward the first proximal end is the reverse direction; The second chromatographic column has a second proximal end and a distal end, and the second proximal end is an end of the second chromatographic column close to the sample inlet, and the second distal end is an end of the second chromatographic column away from the sample inlet, and the direction from the second proximal end toward the second distal end is the positive direction, and the direction from the second distal end toward the second proximal end is the reverse direction.

[0009] By adopting the above technical solution, the arrangement of the first proximal end, the first distal end, the second proximal end and the second distal end helps to cooperate with the flow path guiding component to guide the flow path of the sample, thereby helping to adjust the flow direction of the sample in the first chromatographic column and the second chromatographic column.

[0010] In a specific embodiment, when the flow guide assembly is configured to respond to a control signal corresponding to a first state, the sample flows into the sample inlet, flows through the first chromatographic column in a forward direction, and flows out of the sample outlet, and a control valve 1 and a control valve 2 are sequentially provided on the pipeline between the sample inlet and the first proximal end, and a control valve 3 is provided on the pipeline between the first distal end and the sample outlet; When the flow path guiding component is configured to respond to the control signal corresponding to the second state, the sample flows into the sample inlet, flows through the second chromatographic column in the forward direction, and flows out of the sample outlet, and control valve one and control valve four are sequentially arranged on the pipeline between the sample inlet and the second proximal end, and control valve five is arranged on the pipeline between the second distal end and the sample outlet.

[0011] By adopting the above technical solution, after responding to the first state of the control signal, the opening of control valves 1, 2, and 3 helps guide the sample to flow solely through the first chromatographic column, and the sample flows from the first proximal end to the first distal end within the first chromatographic column. After responding to the second state of the control signal, the opening of control valves 1, 4, and 5 helps guide the sample to flow solely through the second chromatographic column, and the sample flows from the second proximal end to the second distal end within the second chromatographic column.

[0012] In a specific embodiment, when the flow guide assembly is configured to respond to a control signal corresponding to the third state, the sample flows into the sample inlet, flows through the first chromatographic column in the reverse direction, and flows out of the sample outlet, and a control valve six and a control valve seven are sequentially provided on the pipeline between the sample inlet and the first distal end, and a control valve two and a control valve eight are sequentially provided on the pipeline between the first proximal end and the sample outlet; When the flow path guiding component is configured to respond to the control signal corresponding to the fourth state, the sample flows into the sample inlet, flows through the second chromatographic column in the reverse direction, and flows out of the sample outlet, and control valve six and control valve nine are sequentially arranged on the pipeline between the sample inlet and the second distal end, and control valve four and control valve eight are sequentially arranged on the pipeline between the second proximal end and the sample outlet.

[0013] By adopting the above technical solution, after responding to the third state of the control signal, the opening of control valves six, seven, two, and eight facilitates directing the sample to flow solely through the first chromatographic column, with the sample flowing from the first distal end toward the first proximal end within the first chromatographic column. After responding to the fourth state of the control signal, the opening of control valves six, nine, four, and eight facilitates directing the sample to flow solely through the second chromatographic column, with the sample flowing from the second distal end toward the second proximal end within the second chromatographic column.

[0014] In a specific embodiment, when the flow guide assembly is configured to respond to a control signal corresponding to a fifth state, the sample flows into the sample inlet, flows through the first chromatographic column in a forward direction, then flows through the second chromatographic column in a forward direction, and then flows out of the sample outlet, and control valve 1 and control valve 2 are sequentially provided on the pipeline between the sample inlet and the first proximal end, control valve 10 is provided on the pipeline between the first distal end and the second proximal end, and control valve 5 is provided on the pipeline between the second distal end and the sample outlet; When the flow path guiding component is configured to respond to the control signal corresponding to the sixth state, the sample flows into the sample inlet, flows through the second chromatographic column in the forward direction, and then flows through the first chromatographic column in the forward direction, and then flows out from the sample outlet, and control valve one and control valve four are sequentially arranged on the pipeline between the sample inlet and the second proximal end, control valve eleven is arranged on the pipeline between the second distal end and the first proximal end, and control valve three is arranged on the pipeline between the first distal end and the sample outlet.

[0015] By adopting the above technical solution, after responding to the fifth state of the control signal, the opening of control valves 1, 2, 10, and 5 helps guide the sample to flow sequentially through the first chromatographic column and the second chromatographic column, with the sample flowing from the first proximal end toward the first distal end in the first chromatographic column, and the sample flowing from the second proximal end toward the second distal end in the second chromatographic column. After responding to the sixth state of the control signal, the opening of control valves 1, 4, 11, and 3 helps guide the sample to flow sequentially through the second chromatographic column and the first chromatographic column, with the sample flowing from the second proximal end toward the second distal end in the second chromatographic column, and the sample flowing from the first proximal end toward the first distal end in the first chromatographic column.

[0016] In a specific embodiment, when the flow guide assembly is configured to respond to a control signal corresponding to the seventh state, the sample flows into the sample inlet, flows through the first chromatographic column in the reverse direction, then flows through the second chromatographic column in the reverse direction, and then flows out of the sample outlet, and a control valve six and a control valve seven are sequentially provided on the pipeline between the sample inlet and the first distal end, a control valve eleven is provided on the pipeline between the first proximal end and the second distal end, and a control valve four and a control valve eight are sequentially provided on the pipeline between the second proximal end and the sample outlet; When the flow path guiding component is configured to respond to the control signal corresponding to the eighth state, the sample flows into the sample inlet, flows through the second chromatographic column in the reverse direction, and then flows through the first chromatographic column in the reverse direction, and then flows out from the sample outlet, and control valve six and control valve nine are sequentially arranged on the pipeline between the sample inlet and the second distal end, control valve ten is arranged on the pipeline between the second proximal end and the first distal end, and control valve two and control valve eight are sequentially arranged on the pipeline between the first proximal end and the sample outlet.

[0017] By adopting the above technical solution, after responding to the seventh state of the control signal, the opening of control valves 6, 7, 4, and 8 helps guide the sample to flow sequentially through the first chromatographic column and the second chromatographic column, and the sample flows from the first distal end toward the first proximal end in the first chromatographic column, and the sample flows from the second distal end toward the second proximal end in the second chromatographic column. After responding to the eighth state of the control signal, the opening of control valves 6, 9, 10, 2, and 8 helps guide the sample to flow sequentially through the second chromatographic column and the first chromatographic column, and the sample flows from the second distal end toward the second proximal end in the second chromatographic column, and the sample flows from the first distal end toward the first proximal end in the first chromatographic column.

[0018] In a specific embodiment, when the flow path guiding component is configured to respond to the control signal corresponding to the ninth state, the sample flows into the sample inlet and flows out of the sample outlet, and a control valve twelve is provided on the pipeline between the sample inlet and the sample outlet.

[0019] By adopting the above technical solution, after responding to the ninth state of the control signal, the opening of the control valve 12 helps to guide the sample to flow directly from the sample inlet to the sample outlet.

[0020] In a specific possible implementation scheme, the valve unit also includes a waste liquid outlet for waste liquid to flow out. When the flow path guiding component is configured to respond to the control signal corresponding to the tenth state, the sample flows into the sample inlet and then flows out of the waste liquid outlet, and a control valve thirteen is provided on the pipeline between the sample inlet and the waste liquid outlet.

[0021] By adopting the above technical solution, after responding to the tenth state of the control signal, the opening of the control valve thirteen helps to guide the waste liquid to flow out from the waste liquid outlet.

[0022] In summary, this application includes at least one of the following beneficial technical effects: 1. The present application provides a flow path guiding assembly, which helps guide the flow path of the sample within the valve unit, thereby helping to guide the sample to flow through the first chromatographic column or the second chromatographic column or the first chromatographic column and the second chromatographic column according to the set flow path, helping to prevent the execution of continuous chromatography from being interrupted, thereby helping to improve the continuity and convenience of the operation during the execution of continuous chromatography, and further helping to improve the execution efficiency of continuous chromatography; 2. In the present application, the first proximal end, the first distal end, the second proximal end and the second distal end are arranged so that the first proximal end, the first distal end, the second proximal end and the second distal end help to cooperate with the flow guiding component to guide the flow path of the sample, thereby helping to adjust the flow direction of the sample in the first chromatographic column and the second chromatographic column, thereby helping to further improve the continuity and convenience of operations during the execution of continuous chromatography, and further improve the execution efficiency of continuous chromatography. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a schematic diagram of the flow path in response to the control signal corresponding to the first state in an embodiment of the present application.

[0024] Figure 2 This is a schematic diagram of the flow path in response to the control signal corresponding to the second state in an embodiment of the present application.

[0025] Figure 3 This is a schematic diagram of the flow path in response to the control signal corresponding to the third state in an embodiment of the present application.

[0026] Figure 4 This is a schematic diagram of the flow path in response to the control signal corresponding to the fourth state in an embodiment of the present application.

[0027] Figure 5 This is a schematic diagram of the flow path in response to the control signal corresponding to the fifth state in an embodiment of the present application.

[0028] Figure 6 This is a schematic diagram of the flow path in response to the control signal corresponding to the sixth state in an embodiment of the present application.

[0029] Figure 7 This is a schematic diagram of the flow path in response to the control signal corresponding to the seventh state in an embodiment of the present application.

[0030] Figure 8 This is a schematic diagram of the flow path when responding to the control signal corresponding to the eighth state in an embodiment of the present application.

[0031] Figure 9 This is a schematic diagram of the flow path in response to the control signal corresponding to the ninth state in an embodiment of the present application.

[0032] Figure 10 This is a schematic diagram of the flow path in response to the control signal corresponding to the tenth state in an embodiment of the present application.

[0033] Explanation of the accompanying drawings: 1. First chromatographic column; 2. Second chromatographic column; 3. Waste liquid outlet; 4. First proximal end; 5. First distal end; 6. Control valve 12; 7. Second proximal end; 8. Second distal end; 9. Sample inlet; 10. Sample outlet; 11. Control valve 13; 12. Control valve 1; 13. Control valve 2; 14. Control valve 3; 15. Control valve 4; 16. Control valve 5; 17. Control valve 6; 18. Control valve 7; 19. Control valve 8; 20. Control valve 9; 21. Control valve 10; 22. Control valve 11. DETAILED DESCRIPTION

[0034] The present application is further described in detail below with reference to the accompanying drawings.

[0035] The present application embodiment discloses a valve unit for a chromatography system, referring to Figure 1 The valve unit includes a sample inlet 9, a sample outlet 10 and a waste liquid outlet 3. The sample inlet 9, the sample outlet 10 and the waste liquid outlet 3 are connected by pipelines. The sample inlet 9 is configured to flow in the sample, the sample outlet 10 is configured to flow out the sample, and the waste liquid outlet 3 is configured to flow out the waste liquid.

[0036] Reference Figure 1 A first chromatographic column 1 and a second chromatographic column 2 are installed on the pipeline between the sample inlet 9 and the sample outlet 10, and the first chromatographic column 1 has a first proximal end 4 and a first distal end 5, the first proximal end 4 is the end of the first chromatographic column 1 close to the sample inlet 9, and the first distal end 5 is the end of the first chromatographic column 1 away from the sample inlet 9, and the direction of the first proximal end 4 toward the first distal end 5 is the positive direction, and the direction of the first distal end 5 toward the first proximal end 4 is the reverse direction; the second chromatographic column 2 has a second proximal end 7 and a second distal end 8, the second proximal end 7 is the end of the second chromatographic column 2 close to the sample inlet 9, and the second distal end 8 is the end of the second chromatographic column 2 away from the sample inlet 9, and the direction of the second proximal end 7 toward the second distal end 8 is the positive direction, and the direction of the second distal end 8 toward the second proximal end 7 is the reverse direction, and the positive direction in the first chromatographic column 1 and the positive direction in the second chromatographic column 2 are the same.

[0037] Reference Figure 1 The valve unit also includes a flow path guiding assembly, which includes control valve 1 12, control valve 2 13, control valve 3 14, control valve 4 15, control valve 5 16, control valve 6 17, control valve 7 18, control valve 8 19, control valve 9 20, control valve 10 21, control valve 11 22, control valve 12 6, and control valve 13 11, installed on the pipeline between the sample inlet 9, the sample outlet 10, and the waste liquid outlet 3. The valve unit also includes a control system, which includes a memory and a processor, and the memory stores control signals for multiple states executed by the processor.

[0038] Reference Figure 1When the processor executes the first state of the control signal, the control valve 12 and the control valve 2 13 arranged in sequence on the pipeline between the sample inlet 9 and the first proximal end 4, and the control valve 3 14 arranged on the pipeline between the first distal end 5 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows into the sample inlet 9, flows through the first chromatographic column 1 in a forward direction, and then flows out from the sample outlet 10.

[0039] Reference Figure 2 When the processor executes the second state of the control signal, the control valve 12 and the control valve 4 15 arranged in sequence on the pipeline between the sample inlet 9 and the second proximal end 7, and the control valve 5 16 arranged on the pipeline between the second distal end 8 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows into the sample inlet 9, flows through the second chromatographic column 2 in the forward direction, and then flows out from the sample outlet 10.

[0040] Reference Figure 3 When the processor executes the third state of the control signal, the control valve six 17 and the control valve seven 18 arranged in sequence on the pipeline between the sample inlet 9 and the first distal end 5, and the control valve two 13 and the control valve eight 19 arranged in sequence on the pipeline between the first proximal end 4 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows into the sample inlet 9, flows in the reverse direction through the first chromatographic column 1, and then flows out from the sample outlet 10.

[0041] Reference Figure 4 When the processor executes the fourth state of the control signal, the control valve six 17 and the control valve nine 20 arranged in sequence on the pipeline between the sample inlet 9 and the second distal end 8, and the control valve four 15 and the control valve eight 19 arranged in sequence on the pipeline between the second proximal end 7 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows in from the sample inlet 9, flows through the second chromatographic column 2 in the reverse direction, and then flows out from the sample outlet 10.

[0042] Reference Figure 5 When the processor executes the fifth state of the control signal, the control valve 12 and the control valve 2 13 arranged in sequence on the pipeline between the sample inlet 9 and the first proximal end 4, the control valve 10 21 arranged on the pipeline between the first distal end 5 and the second proximal end 7, and the control valve 5 16 arranged on the pipeline between the second distal end 8 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows in from the sample inlet 9, flows through the first chromatographic column 1 in the forward direction, then flows through the second chromatographic column 2 in the forward direction, and then flows out from the sample outlet 10.

[0043] Reference Figure 6When the processor executes the sixth state of the control signal, the control valve 12 and the control valve 4 15 arranged in sequence on the pipeline between the sample inlet 9 and the second proximal end 7, the control valve 11 22 arranged on the pipeline between the second distal end 8 and the first proximal end 4, and the control valve 3 14 arranged on the pipeline between the first distal end 5 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows in from the sample inlet 9, flows through the second chromatographic column 2 in the forward direction, then flows through the first chromatographic column 1 in the forward direction, and then flows out from the sample outlet 10.

[0044] Reference Figure 7 When the processor executes the seventh state of the control signal, the control valve six 17 and the control valve seven 18 arranged in sequence on the pipeline between the sample inlet 9 and the first distal end 5, the control valve eleven 22 arranged in sequence on the pipeline between the first proximal end 4 and the second distal end 8, and the control valve four 15 and the control valve eight 19 arranged in sequence on the pipeline between the second proximal end 7 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows in from the sample inlet 9, flows through the first chromatographic column 1 in the reverse direction, then flows through the second chromatographic column 2 in the reverse direction, and then flows out from the sample outlet 10.

[0045] Reference Figure 8 When the processor executes the eighth state of the control signal, the control valve six 17 and the control valve nine 20 arranged in sequence on the pipeline between the sample inlet 9 and the second distal end 8, the control valve ten 21 arranged in sequence on the pipeline between the second proximal end 7 and the first distal end 5, and the control valve two 13 and the control valve eight 19 arranged in sequence on the pipeline between the first proximal end 4 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows in from the sample inlet 9, flows through the second chromatographic column 2 in the reverse direction, then flows through the first chromatographic column 1 in the reverse direction, and then flows out from the sample outlet 10.

[0046] Reference Figure 9 When the processor executes the ninth state of the control signal, the control valve 12 6 arranged on the pipeline between the sample inlet 9 and the sample outlet 10 changes from a closed state to an open state, so that the sample flows into the sample inlet 9 and flows out of the sample outlet 10.

[0047] Reference Figure 10 When the processor executes the tenth state of the control signal, the control valve thirteen 11 arranged on the pipeline between the sample inlet 9 and the waste liquid outlet 3 changes from a closed state to an open state, so that the sample flows into the sample inlet 9 and flows out of the waste liquid outlet 3.

[0048] The implementation principle of the embodiment of the present application is: the first state of the control signal is executed, and the control valve 12 and the control valve 2 13 arranged in sequence on the pipeline between the sample inlet 9 and the first proximal end 4, and the control valve 3 14 arranged on the pipeline between the first distal end 5 and the sample outlet 10 are all changed from a closed state to an open state, so that after the sample flows into the sample inlet 9, it flows through the first chromatographic column 1 in the forward direction, and then flows out from the sample outlet 10.

[0049] The second state of the control signal is executed, and the control valve 12 and the control valve 4 15 arranged in sequence on the pipeline between the sample inlet 9 and the second proximal end 7, and the control valve 5 16 arranged on the pipeline between the second distal end 8 and the sample outlet 10 are all changed from a closed state to an open state, so that after the sample flows into the sample inlet 9, it flows through the second chromatographic column 2 in the forward direction, and then flows out from the sample outlet 10.

[0050] When the third state of the control signal is executed, the control valve six 17 and the control valve seven 18 arranged in sequence on the pipeline between the sample inlet 9 and the first distal end 5, and the control valve two 13 and the control valve eight 19 arranged in sequence on the pipeline between the first proximal end 4 and the sample outlet 10 are all changed from a closed state to an open state, so that after the sample flows into the sample inlet 9, it flows in the reverse direction through the first chromatographic column 1 and then flows out from the sample outlet 10.

[0051] When the fourth state of the control signal is executed, the control valve six 17 and the control valve nine 20 arranged in sequence on the pipeline between the sample inlet 9 and the second distal end 8, and the control valve four 15 and the control valve eight 19 arranged in sequence on the pipeline between the second proximal end 7 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows in from the sample inlet 9, flows through the second chromatographic column 2 in the reverse direction, and then flows out from the sample outlet 10.

[0052] When the fifth state of the control signal is executed, the control valve one 12 and the control valve two 13 arranged in sequence on the pipeline between the sample inlet 9 and the first proximal end 4, the control valve ten 21 arranged on the pipeline between the first distal end 5 and the second proximal end 7, and the control valve five 16 arranged on the pipeline between the second distal end 8 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows in from the sample inlet 9, flows through the first chromatographic column 1 in the forward direction, and then flows through the second chromatographic column 2 in the forward direction, and then flows out from the sample outlet 10.

[0053] When the sixth state of the control signal is executed, the control valve one 12 and the control valve four 15 arranged in sequence on the pipeline between the sample inlet 9 and the second proximal end 7, the control valve eleven 22 arranged on the pipeline between the second distal end 8 and the first proximal end 4, and the control valve three 14 arranged on the pipeline between the first distal end 5 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows in from the sample inlet 9, flows through the second chromatographic column 2 in the forward direction, and then flows through the first chromatographic column 1 in the forward direction, and then flows out from the sample outlet 10.

[0054] When the seventh state of the control signal is executed, the control valve six 17 and the control valve seven 18 arranged in sequence on the pipeline between the sample inlet 9 and the first distal end 5, the control valve eleven 22 arranged in sequence on the pipeline between the first proximal end 4 and the second distal end 8, and the control valve four 15 and the control valve eight 19 arranged in sequence on the pipeline between the second proximal end 7 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows in from the sample inlet 9, flows through the first chromatographic column 1 in the reverse direction, and then flows through the second chromatographic column 2 in the reverse direction, and then flows out from the sample outlet 10.

[0055] When the eighth state of the control signal is executed, the control valve six 17 and the control valve nine 20 arranged in sequence on the pipeline between the sample inlet 9 and the second distal end 8, the control valve ten 21 arranged in sequence on the pipeline between the second proximal end 7 and the first distal end 5, and the control valve two 13 and the control valve eight 19 arranged in sequence on the pipeline between the first proximal end 4 and the sample outlet 10 are all changed from a closed state to an open state, so that the sample flows in from the sample inlet 9, flows through the second chromatographic column 2 in the reverse direction, and then flows through the first chromatographic column 1 in the reverse direction, and then flows out from the sample outlet 10.

[0056] When the ninth state of the control signal is executed, the control valve 12 6 arranged on the pipeline between the sample inlet 9 and the sample outlet 10 changes from a closed state to an open state, so that the sample flows into the sample inlet 9 and flows out of the sample outlet 10 .

[0057] Execute the tenth state of the control signal. When the processor executes the control signal ten, the control valve thirteen 11 arranged on the pipeline between the sample inlet 9 and the waste liquid outlet 3 changes from a closed state to an open state, so that the sample flows into the sample inlet 9 and flows out of the waste liquid outlet 3.

[0058] The above are all preferred embodiments of the present application, and are not intended to limit the scope of protection of the present application. Therefore, any equivalent changes made based on the structure, shape, and principle of the present application should be included in the scope of protection of the present application.

Claims

1. A valve unit for a chromatography system, characterized in that: The invention comprises a sample inlet (9) and a sample outlet (10), wherein the sample inlet (9) and the sample outlet (10) are connected via a pipeline, and a first chromatographic column (1) and a second chromatographic column (2) are arranged on the pipeline between the sample inlet (9) and the sample outlet (10); and further comprises a flow path guiding component, wherein the flow path guiding component is used to respond to a control signal and thereby guide the flow of the sample in the valve unit, and under the action of the flow path guiding component, when the sample needs to flow through the first chromatographic column (1) and the second chromatographic column (2) in an unsequential manner, the flow direction of the sample in the first chromatographic column (1) and the second chromatographic column (2) is the same.

2. A valve unit for a chromatography system according to claim 1, characterized in that: The first chromatographic column (1) has a first proximal end (4) and a first distal end (5), wherein the first proximal end (4) is an end of the first chromatographic column (1) close to the sample inlet (9), and the first distal end (5) is an end of the first chromatographic column (1) away from the sample inlet (9), and the direction from the first proximal end (4) toward the first distal end (5) is a positive direction, and the direction from the first distal end (5) toward the first proximal end (4) is a negative direction; The second chromatographic column (2) has a second proximal end (7) and a second distal end (8), wherein the second proximal end (7) is the end of the second chromatographic column (2) close to the sample inlet (9), and the second distal end (8) is the end of the second chromatographic column (2) away from the sample inlet (9), and the direction from the second proximal end (7) toward the second distal end (8) is the positive direction, and the direction from the second distal end (8) toward the second proximal end (7) is the reverse direction.

3. The valve unit for a chromatography system according to claim 2, characterized in that: When the flow path guiding component is configured to respond to a control signal corresponding to a first state, a sample flows in from the sample inlet (9), flows through the first chromatographic column (1) in a forward direction, and flows out from the sample outlet (10), and a control valve 1 (12) and a control valve 2 (13) are sequentially provided on the pipeline between the sample inlet (9) and the first proximal end (4), and a control valve 3 (14) is provided on the pipeline between the first distal end (5) and the sample outlet (10); When the flow path guiding component is configured to respond to the control signal corresponding to the second state, the sample flows in from the sample inlet (9), flows through the second chromatographic column (2) in the forward direction, and flows out from the sample outlet (10), and a control valve one (12) and a control valve four (15) are sequentially arranged on the pipeline between the sample inlet (9) and the second proximal end (7), and a control valve five (16) is arranged on the pipeline between the second distal end (8) and the sample outlet (10).

4. The valve unit for a chromatography system according to claim 2, characterized in that: When the flow path guiding component is configured to respond to the control signal corresponding to the third state, the sample flows in from the sample inlet (9), flows through the first chromatographic column (1) in the reverse direction, and flows out from the sample outlet (10), and a control valve six (17) and a control valve seven (18) are sequentially provided on the pipeline between the sample inlet (9) and the first distal end (5), and a control valve two (13) and a control valve eight (19) are sequentially provided on the pipeline between the first proximal end (4) and the sample outlet (10); When the flow path guiding component is configured to respond to the control signal corresponding to the fourth state, the sample flows in from the sample inlet (9), flows through the second chromatographic column (2) in the reverse direction, and flows out from the sample outlet (10), and a control valve six (17) and a control valve nine (20) are sequentially provided on the pipeline between the sample inlet (9) and the second distal end (8), and a control valve four (15) and a control valve eight (19) are sequentially provided on the pipeline between the second proximal end (7) and the sample outlet (10).

5. The valve unit for a chromatography system according to claim 2, characterized in that: When the flow path guiding component is configured to respond to the control signal corresponding to the fifth state, the sample flows in from the sample inlet (9), flows through the first chromatographic column (1) in the forward direction, then flows through the second chromatographic column (2) in the forward direction, and then flows out from the sample outlet (10), and a control valve 1 (12) and a control valve 2 (13) are sequentially provided on the pipeline between the sample inlet (9) and the first proximal end (4), a control valve 10 (21) is provided on the pipeline between the first distal end (5) and the second proximal end (7), and a control valve 5 (16) is provided on the pipeline between the second distal end (8) and the sample outlet (10); When the flow path guiding component is configured to respond to the control signal corresponding to the sixth state, the sample flows in from the sample inlet (9), flows through the second chromatographic column (2) in the forward direction, and then flows through the first chromatographic column (1) in the forward direction, and then flows out from the sample outlet (10), and a control valve one (12) and a control valve four (15) are sequentially arranged on the pipeline between the sample inlet (9) and the second proximal end (7), a control valve eleven (22) is arranged on the pipeline between the second distal end (8) and the first proximal end (4), and a control valve three (14) is arranged on the pipeline between the first distal end (5) and the sample outlet (10).

6. The valve unit for a chromatography system according to claim 2, characterized in that: When the flow path guiding component is configured to respond to the control signal corresponding to the seventh state, the sample flows in from the sample inlet (9), flows through the first chromatographic column (1) in the reverse direction, then flows through the second chromatographic column (2) in the reverse direction, and then flows out from the sample outlet (10), and a control valve six (17) and a control valve seven (18) are sequentially provided on the pipeline between the sample inlet (9) and the first distal end (5), a control valve eleven (22) is provided on the pipeline between the first proximal end (4) and the second distal end (8), and a control valve four (15) and a control valve eight (19) are sequentially provided on the pipeline between the second proximal end (7) and the sample outlet (10); When the flow path guiding component is configured to respond to the control signal corresponding to the eighth state, the sample flows in from the sample inlet (9), flows through the second chromatographic column (2) in the reverse direction, and then flows through the first chromatographic column (1) in the reverse direction, and then flows out from the sample outlet (10), and control valve six (17) and control valve nine (20) are sequentially provided on the pipeline between the sample inlet (9) and the second distal end (8), control valve ten (21) is provided on the pipeline between the second proximal end (7) and the first distal end (5), and control valve two (13) and control valve eight (19) are sequentially provided on the pipeline between the first proximal end (4) and the sample outlet (10).

7. The valve unit for a chromatography system according to claim 1, characterized in that: When the flow path guiding component is configured to respond to the control signal corresponding to the ninth state, the sample flows into the sample inlet (9) and then flows out of the sample outlet (10), and a control valve twelve (6) is provided on the pipeline between the sample inlet (9) and the sample outlet (10).

8. The valve unit for a chromatography system according to claim 1, characterized in that: The valve unit also includes a waste liquid outlet (3) for waste liquid to flow out. When the flow path guiding component is configured to respond to the control signal corresponding to the tenth state, the sample flows into the sample inlet (9) and then flows out of the waste liquid outlet (3), and a control valve thirteen (11) is provided on the pipeline between the sample inlet (9) and the waste liquid outlet (3).

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