Wireless powering device and method for a neurostimulator

Abstract

The application provides a wireless energy supply device and method for a neural stimulator. The wireless energy supply device comprises a transmitter for transmitting energy supply electromagnetic waves to the neural stimulator and increasing the transmission power of the energy supply electromagnetic waves; an impedance calculation unit electrically connected to the transmitter, the impedance calculation unit is used for monitoring the corresponding reflected impedance of the neural stimulator according to the input current and input voltage of the transmitter, and in the case of identifying an initial impedance mutation point, maintaining the transmitter constant at the transmission power corresponding to the initial impedance mutation point, determining the pre-obtained boot voltage of the neural stimulator as the working voltage estimate value of the neural stimulator, performing parameter configuration, and calculating the state estimate value of the neural stimulator according to the reflected impedance monitoring sequence corresponding to the parameter configuration execution stage of the neural stimulator, and controlling the transmission power of the energy supply electromagnetic waves according to the state estimate value.

Description

Technical Field

[0001] The present application relates to the technical field of stimulators, and in particular to a wireless power supply device and a wireless power supply method for a neurostimulator. Background Art

[0002] A neurostimulator is a device used to deliver electrical signals to specific nerve regions. Its primary goal is to achieve therapeutic effects by modulating the electrical activity of neurons. Because a neurostimulator is surgically implanted into human tissue and electrically stimulates muscle or nerve tissue as needed for the patient's condition, it must be as small as possible to minimize surgical risks. To reduce the size of the neurostimulator, wireless power supply and wireless communication are implemented to simplify the energy storage and communication units within the neurostimulator.

[0003] However, this solution also brings new technical problems. That is, in the case of wireless power supply, the neurostimulator needs to be equipped with a state sampling circuit and a wireless communication circuit to feed back the current working status of the neurostimulator to the external power supply device. The circuit area of ​​the state sampling circuit and the wireless communication circuit is large, which causes the size of the neurostimulator to increase. In addition, the feedback on the working status requires back-and-forth communication encoding and decoding, and the feedback is poor in real time and low in efficiency. Summary of the Invention

[0004] In view of this, the present application provides a wireless power supply device and a wireless power supply method for a neurostimulator.

[0005] Specifically, this application is implemented through the following technical solutions:

[0006] According to a first aspect of an embodiment of the present specification, a wireless power supply device for a neurostimulator is provided, comprising: a transmitter for transmitting power supply electromagnetic waves to the neurostimulator and increasing the transmission power of the power supply electromagnetic waves; an impedance calculation unit, the impedance calculation unit being electrically connected to the transmitter, for calculating the reflected impedance corresponding to the neurostimulator according to the input current and input voltage of the transmitter, and maintaining the transmission power of the transmitter constant at the corresponding initial impedance mutation point when an initial impedance mutation point is identified, and determining the pre-acquired power-on voltage of the neurostimulator as the estimated working voltage of the neurostimulator, and executing parameter configuration and calculating the state estimation value of the neurostimulator according to the reflected impedance monitoring sequence corresponding to the neurostimulator in the parameter configuration execution stage, and controlling the transmission power of the power supply electromagnetic wave according to the state estimation value.

[0007] According to the second aspect of the embodiments of this specification, a wireless power supply method for a neurostimulator is provided, which is applied to the wireless power supply device of the first aspect of this specification, including: transmitting power supply electromagnetic waves to the neurostimulator through a transmitter and increasing the transmission power of the power supply electromagnetic waves; monitoring the reflected impedance corresponding to the neurostimulator according to the input current and input voltage of the transmitter and identifying the impedance mutation point; when the initial impedance mutation point is identified, maintaining the transmission power of the transmitter constant at the corresponding initial impedance mutation point and determining the pre-acquired power-on voltage of the neurostimulator as the estimated working voltage of the neurostimulator; and executing parameter configuration and calculating the state estimation value of the neurostimulator according to the reflected impedance monitoring sequence corresponding to the neurostimulator in the parameter configuration execution stage; and controlling the transmission power of the power supply electromagnetic wave according to the state estimation value.

[0008] According to a third aspect of the embodiments of this specification, an electronic device is provided, comprising a processor and a memory for storing processor-executable instructions; wherein the processor is configured to implement the wireless power supply method of the second aspect of the embodiments of this specification.

[0009] According to a fourth aspect of the embodiments of this specification, a computer-readable storage medium is provided, on which a computer program is stored. When the computer program is executed by a processor, the wireless power supply method of the second aspect of the embodiments of this specification is implemented.

[0010] According to a fifth aspect of the embodiments of this specification, a computer program product is provided, comprising a computer program / instruction, which, when executed by a processor, implements the wireless power supply method of the second aspect of the embodiments of this specification.

[0011] In the technical solution of the present application, the transmitter of the wireless energy supply device gradually increases the transmission power of the energy supply electromagnetic wave. In the process of increasing the transmission power of the energy supply electromagnetic wave, the impedance calculation unit continuously monitors the reflected impedance corresponding to the neurostimulator and identifies the impedance mutation point. Since the reflected impedance corresponding to the power-on voltage before and after the neurostimulator is mutated, it is possible to determine that the neurostimulator is in the power-on voltage state based on the transmission power corresponding to the initial impedance mutation point. The neurostimulator being in the power-on voltage state indicates that the neurostimulator has entered the normal working mode and starts to execute parameter configuration under the circumstances. Since the reflected impedance monitoring sequence corresponding to the parameter configuration execution phase can reflect the neurostimulation The output pulse waveform of the neurostimulator can be obtained by the wireless energy supply device, so the actual working parameters of the neurostimulator can be predicted according to the monitored reflected impedance monitoring sequence, without the need for the neurostimulator to feed back the state value of the working parameters to the wireless functional device. As a result, the neurostimulator does not need to be configured with a sampling circuit and a special wireless communication circuit, which helps to achieve the miniaturization design of the neurostimulator; and the state estimation value of the neurostimulator is calculated in real time by the wireless energy supply device according to the reflected impedance monitoring sequence, which does not require end-to-end wireless transmission or encoding and decoding, and therefore has the characteristic of short response time, which enables the wireless energy supply device to supply energy quickly and improve the efficiency of wireless energy supply.

[0012] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present disclosure. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the specification and, together with the description, serve to explain the principles of the specification.

[0014] Figure 1 is a circuit diagram of a wireless power supply system according to an exemplary embodiment of this specification;

[0015] Figure 2 yes Figure 1 The equivalent circuit diagram of the wireless power supply system shown;

[0016] Figure 3 This is a constant current control principle diagram according to an exemplary embodiment of the present specification;

[0017] Figure 4 This is a constant voltage control principle diagram according to an exemplary embodiment of the present specification;

[0018] Figure 5 This is a schematic structural diagram of a wireless energy supply device according to an exemplary embodiment of this specification;

[0019] Figure 6is a schematic diagram showing a comparison between an output pulse waveform, a reflected impedance waveform, and a load impedance waveform during a configuration parameter execution phase according to an exemplary embodiment of this specification;

[0020] Figure 7 This is a flow chart of a wireless energy supply process according to an exemplary embodiment of this specification;

[0021] Figure 8 is a flow chart of a method for wireless power supply of a neurostimulator according to an exemplary embodiment of this specification;

[0022] Figure 9 is a schematic diagram of an electronic device according to an exemplary embodiment of this specification;

[0023] Figure 10 This is a block diagram of a wireless power supply device for a neurostimulator according to an exemplary embodiment of the present specification. DETAILED DESCRIPTION

[0024] Exemplary embodiments will be described in detail herein, with examples illustrated in the accompanying drawings. In the following description, when referring to the drawings, identical numbers in different figures represent identical or similar elements, unless otherwise indicated. The embodiments described in the following exemplary embodiments are not intended to represent all possible implementations consistent with one or more embodiments of the present application. Rather, they are merely examples of apparatuses and methods consistent with certain aspects of one or more embodiments of the present application, as detailed in the appended claims.

[0025] It should be noted that in other embodiments, the steps of the corresponding method are not necessarily performed in the order shown and described in this application. In some other embodiments, the method may include more or fewer steps than those described in this application. In addition, a single step described in this application may be broken down into multiple steps for description in other embodiments; and multiple steps described in this application may be combined into a single step for description in other embodiments.

[0026] An implantable neurostimulation system usually consists of an external wireless power supply device and a neurostimulator. The neurostimulator is surgically implanted in human tissue and includes electrodes and a pulse generator. The electrodes are placed near the target nerves. Under the control of the pulse generator, the electrodes output pulses through the electrode contacts to achieve electrical stimulation of the target nerves. The external wireless power supply device includes but is not limited to providing electrical energy to the neurostimulator, controlling the parameter configuration and adjustment of the neurostimulator, and transmitting data with the neurostimulator. The external wireless power supply device can generally refer to any electronic device with the above functions. Neurostimulators include but are not limited to spinal cord stimulators (SCS), peripheral nerve stimulators (PNS), and tibial nerve stimulators (TNS).

[0027] In the relevant scheme, when the neurostimulator starts working, the wireless power supply device sends the pre-set stimulation parameters to the neurostimulator through wireless communication technology. The pulse generator of the neurostimulator controls the electrode contacts to output pulses according to the received stimulation parameters. In the process of outputting pulses, the neurostimulator needs to calculate its own working parameter state value through the state sampling circuit, and send the calculated working parameter state value to the wireless power supply device through the wireless communication module, so that the wireless power supply device can adjust the transmission power of the transmitting coil based on the working parameter state value, or perform parameter control of the neurostimulator based on the working parameter state value.

[0028] It can be seen that the relevant technical solutions require the neurostimulator to be equipped with a state sampling circuit and a wireless communication circuit. The required sampling circuit and wireless communication circuit increase the size of the neurostimulator, which is contrary to the miniaturization requirement of the neurostimulator; and the working parameter state value needs to be encoded and decoded when sending and receiving, resulting in poor real-time feedback of the working parameter state value.

[0029] In response to the above problems, the embodiments of the present application improve the circuit structure of the wireless power supply device and design a corresponding wireless power supply strategy. The improved wireless power supply device predicts the real-time working status of the neurostimulator, and the neurostimulator does not need to feedback the real-time status value to the wireless power supply device. Therefore, the neurostimulator itself does not need to be configured with a state sampling circuit and a dedicated wireless communication circuit, which helps to achieve the miniaturization of the neurostimulator.

[0030] To facilitate understanding of the following embodiments of this specification, the relevant technology is first described in detail.

[0031] The neurostimulator is equipped with a receiving coil, and the wireless power supply device is equipped with a transmitting coil. When the wireless power supply device wirelessly supplies power to the neurostimulator, the wireless power supply device continuously transmits power supply electromagnetic waves through the transmitting coil, and the receiving coil couples and receives the power supply electromagnetic waves to supply power to the neurostimulator. As a result, the neurostimulator and the wireless power supply device form a wireless power supply system based on magnetic coupling. In some embodiments, the receiving coil and the transmitting coil also have a wireless communication function. The wireless power supply device of this embodiment can send stimulation parameter configuration values ​​to the neurostimulator through the wireless communication function of the coil, so that the pulse generator of the neurostimulator generates pulses according to the stimulation parameter configuration values, and outputs pulses through the electrode contacts.

[0032] like Figure 1 As shown, the wireless power supply system based on magnetic coupling can be simplified as Figure 1 The circuit structure shown in the figure shows that the wireless power supply system includes a transmitter and a receiver. The transmitter is the wireless power supply device, the receiver is the nerve stimulator, V is the AC energy source of the transmitter, and the AC frequency is the operating frequency of the wireless function.f , Cp is the resonant capacitance of the transmitting end, Cs is the resonant capacitance of the receiving end, Lp is the inductance of the transmitting coil, Ls is the inductance of the receiving coil, M is the mutual inductance coefficient between the receiving coil and the transmitting coil, and RL is the estimated value of the load impedance of the receiving end.

[0033] Figure 1 The wireless power supply system shown can be further simplified as Figure 2 The circuit shown in Figure 1 is shown in Figure 12, where Zr is the reflection impedance from the receiving end to the reflecting end. The reflection impedance can be calculated using formula (1):

[0034] (1)

[0035] In formula (1), , is the angular frequency of the RF signal, f is the RF operating frequency.

[0036] When the transmitter is equipped with a current sampling circuit and a voltage sampling circuit, the sampling current It of the transmitter can be obtained through the current sampling circuit. x , the sampling voltage Ut of the transmitter can be obtained through the voltage sampling circuit x , so that the sampling current It at the transmitter can also be x And the sampling voltage Ut of the transmitter x Calculate the reflected impedance value Zr:

[0037] (2)

[0038] It is worth noting that in actual circuits, both the transmitting coil and the receiving coil have their own internal resistance. Therefore, considering the internal resistance of the coil itself, the reflected impedance Zr should be:

[0039] (3)

[0040] Combining the above formula (1) and formula (3), the load impedance estimation value RL corresponding to the receiving end can be calculated by the following formula (4):

[0041] (4)

[0042] In formula (3) and formula (4), Rp is the internal resistance of the transmitting coil, and Rs is the internal resistance of the receiving coil. The values ​​of these two internal resistances can be measured during the research and development stage.

[0043] The pulse generator of the neurostimulator generates pulses in constant voltage mode or constant current mode. Figure 3The constant current source control method shown controls the impedance value of the variable resistor Rx. Under the current voltage, Vs / (Rx+Rcd)=Iset, where Rcd is the estimated load impedance of the electrode contact, Iset is the configured value of the pulse amplitude parameter, and Vs is the estimated current operating voltage of the neurostimulator. When the operating voltage of the neurostimulator is insufficient, the pulse generator drives the variable resistor Rx to a minimum value. Since the resistance of Rx is small and negligible, the estimated equivalent resistance of the pulse generator RI=Rcd. It is worth noting that when the operating voltage of the neurostimulator is insufficient, even if the variable resistor Rx reaches the minimum value, the pulse amplitude generated by the pulse generator cannot reach Iset. At this time, the wireless energy supply device can increase the transmission power to ensure that the operating voltage of the neurostimulator is sufficient. When the operating voltage of the neurostimulator is sufficient, the estimated equivalent resistance of the pulse generator is RI = Vs / Iset. Since Rcd can be calculated when the operating voltage is insufficient, the wireless power supply device can obtain the estimated operating voltage Vs of the neurostimulator at each stage according to the configured wireless power supply strategy, and can calculate RL by formula (4). Since the parallel impedance value of the standby load impedance RL0 of the neurostimulator and RI is equal to the estimated load impedance of the neurostimulator RL = RL0 / / RI, where RL0 = V0 / I0, V0 and I0 are the power-on voltage and standby current of the neurostimulator, respectively, and their values ​​can be measured in the research and development stage, the wireless power supply device can thus predict the pulse amplitude Iout output by the electrode contact in real time.

[0044] The pulse generator operates in constant voltage mode. Figure 4 The linear voltage regulation control method shown generates pulses. The pulse generator adjusts the variable resistor Rx to make the load voltage of the electrode contact the set value Vset. When Vset is less than the start-up voltage V0 of the neurostimulator, the voltage value driven by the pulse generator to Rx is Vset. At this time, the equivalent resistance of the pulse generator is For wireless energy supply devices, RI, RL0, Vs, and Vset in this formula are all known values, so the wireless energy supply device can predict the load impedance Rcd of the electrode contacts. When Vset is greater than the neurostimulator's startup voltage V0, the voltage driven by the pulse generator to Rx is the minimum value that can be ignored, and Vs falls entirely on Rcd. Therefore, the equivalent resistance value of the pulse generator, RI = Rcd, is a constant value. At this time, the wireless energy supply device can increase the transmission power and continuously monitor RI. When RI changes significantly (such as a change of 5%), it indicates that the operating voltage of the neurostimulator is sufficient. The wireless energy supply device maintains the transmission power of the energy supply electromagnetic wave at the transmission power corresponding to the impedance mutation point and can calculate the current operating voltage estimate of the neurostimulator, Vs = RI * (Vset / Rcd).

[0045] Next, the embodiments of this specification are described in detail.

[0046] An embodiment of the present application provides a wireless power supply device for a neurostimulator. Figure 5 A schematic diagram of the structure of a wireless energy supply device is shown. Figure 5 As shown, in this embodiment, the wireless energy supply device includes a transmitter 510 and an impedance calculation unit 520;

[0047] The transmitter 510 is used to transmit energy supply electromagnetic waves to the neurostimulator and gradually increase the transmission power of the energy supply electromagnetic waves;

[0048] The impedance calculation unit 520 is electrically connected to the transmitter 510, and is used to monitor the reflected impedance corresponding to the neurostimulator according to the input current and input voltage of the transmitter, and when an initial impedance mutation point is identified, maintain the transmitter constant at the transmission power corresponding to the initial impedance mutation point and perform parameter configuration, calculate the state estimation value of the neurostimulator according to the reflected impedance monitoring sequence corresponding to the neurostimulator in the parameter configuration execution stage, and control the transmission power of the power supply electromagnetic wave according to the state estimation value.

[0049] The main difference between a neurostimulator's stimulation parameters and state estimates is that the former are typically set by the user, while the latter are parameter estimates reflecting the neurostimulator's operating state and must be acquired through computational or information-collection methods. Stimulation parameters include at least the frequency of the stimulation pulse, unit stimulation time, and stimulation current amplitude (also known as current intensity or pulse amplitude). State estimates include pulse state estimates, operating voltage estimates, and electrode contact load impedance estimates. Pulse state estimates include at least one of the following: output pulse frequency estimates, output pulse width estimates, output pulse interval estimates, and output pulse amplitude estimates.

[0050] The “maintaining the transmission power of the transmitter constant at the transmission power corresponding to the initial impedance mutation point” means that when no control command of the impedance calculation unit is received, the transmission power of the power supply electromagnetic wave is maintained at the transmission power corresponding to the initial impedance mutation point; when a control command of the impedance calculation unit is received, the current radiation power is continued to be maintained or the transmission power is increased according to the control command.

[0051] In related technologies, when providing electromagnetic energy waves to a neurostimulator, a wireless energy supply device is directly turned on to a preset initial power to provide the required operating voltage for the neurostimulator. Unlike related art, this embodiment slowly and gradually increases the transmission power of the energy supply electromagnetic wave. Since the load impedance before and after the neurostimulator is turned on is abrupt, the corresponding reflected impedance of the neurostimulator is also abrupt. During the slowly and gradually increasing process of the energy supply electromagnetic wave, the corresponding reflected impedance of the neurostimulator is monitored at a set frequency. When an initial impedance mutation point is identified, for example, when a reflected impedance change of more than 5% is identified, the transmission power is maintained at the transmission power corresponding to the initial impedance mutation point to keep the neurostimulator operating at the startup voltage. When the neurostimulator operates at the startup voltage, the neurostimulator begins to enter a normal operating mode, at which time parameter configuration can be performed. For example, a stimulation parameter configuration strategy is determined based on the neurostimulator's pulse control mode (constant current mode or constant voltage mode). When the neurostimulator generates pulses in a constant current mode, the stimulation parameters are configured in a multi-stage increment. When the neurostimulator generates pulses in a constant voltage mode, if the target configuration value of the stimulation current amplitude is greater than the startup voltage, the stimulation parameters are configured in a multi-stage increment. If the target configuration value of the stimulation current amplitude is not greater than the startup voltage, the stimulation parameters are directly configured to the target configuration value. After the impedance calculation unit 520 determines the configuration value of the stimulation parameter according to the parameter configuration strategy, it sends the configuration value to the neurostimulator through the transmitting coil. After receiving the configuration value, the neurostimulator enters the parameter configuration execution stage. In the parameter configuration execution stage, the pulse generator generates corresponding pulses according to the configuration value and stimulates the target nerve area through the electrode contacts, such as Figure 6 As shown, in the parameter configuration execution stage, when the neurostimulator does not output a pulse, the load impedance estimation value of the neurostimulator is RL0. During the output pulse period, the load impedance estimation value of the neurostimulator is RL=RL0 / / RI, and the corresponding reflection impedance of the neurostimulator also changes accordingly. Therefore, the state estimation value of the neurostimulator can be calculated based on the waveform data of the reflection impedance monitoring sequence in the parameter configuration execution stage.

[0052] refer to Figure 5It can be seen from the wireless energy supply device shown that the transmitter of the wireless energy supply device of this embodiment gradually increases the transmission power of the energy supply electromagnetic wave. In the process of increasing the transmission power of the energy supply electromagnetic wave, the impedance calculation unit continuously monitors the reflection impedance corresponding to the neurostimulator and identifies the impedance mutation point. Since the reflection impedance corresponding to the power-on voltage of the neurostimulator is a mutation, it can be determined that the neurostimulator is in the power-on voltage state based on the transmission power corresponding to the initial impedance mutation point. The neurostimulator being in the power-on voltage state indicates that the neurostimulator has entered the normal working mode and starts to execute parameter configuration under this condition. Since the reflection impedance monitoring sequence corresponding to the parameter configuration execution stage can reflect The output pulse waveform of the neurostimulator, so the wireless power supply device can predict the actual working parameters of the neurostimulator based on the monitored reflected impedance monitoring sequence, without the need for the neurostimulator to feedback the status value of the working parameters to the wireless functional device, so the neurostimulator does not need to be configured with a sampling circuit and a special wireless communication circuit, which helps to achieve the miniaturization design of the neurostimulator; and the state estimation value of the neurostimulator is calculated in real time by the wireless power supply device based on the reflected impedance monitoring sequence, without the need for end-to-end wireless transmission or encoding and decoding, so it has the characteristics of short response time, enabling the wireless power supply device to quickly supply energy and improve the efficiency of wireless power supply.

[0053] In an illustrated embodiment, the impedance calculation unit 520 is further configured to calculate the mutual inductance between the wireless power supply device and the neural stimulator according to the reflected impedance corresponding to the initial impedance mutation point when the initial impedance mutation point is identified.

[0054] When the initial impedance mutation point is identified, the reflected impedance Zr0 corresponding to the initial impedance mutation point can be obtained, and the mutual inductance coefficient M can be calculated by referring to the following formula (5):

[0055] (5)

[0056] After obtaining the mutual inductance coefficient M, the load impedance estimation value RL of the neurostimulator can be calculated according to the above formula (4), so as to calculate the relevant state estimation value of the neurostimulator through RL.

[0057] In an illustrated embodiment, the transmitter 510 is used to increase the transmission power according to a phased strategy, wherein the phased strategy includes at least two power increase stages, each stage corresponds to a preset power value and a preset duration, the preset power value corresponding to the next stage is higher than the preset power value corresponding to the previous stage, the transmitter automatically enters the initial stage and automatically switches to the next stage after completing the previous stage, and performs stage switching or maintenance based on the control of the impedance calculation unit.

[0058] When the wireless power supply device begins to supply power to the neurostimulator, the transmitter 510 automatically enters the initial stage, and enters the second stage after reaching the preset duration of the initial stage, and automatically switches between stages in this manner. During the automatic switching of stages, if a control command is received from the impedance calculation unit, the control command may include, for example, a power maintenance command and a power increase command. When the power maintenance command is received, the current stage is maintained until a new control command is received; when the power increase command is received, the current stage is directly entered (without maintaining the preset duration) to the next stage, and automatically enters the next stage after reaching the preset duration according to the automatic switching method until a new control command is received. In actual applications, the preset power value corresponding to the next stage can be set according to the set power step. For example, the sum of the preset power value corresponding to the previous stage and the set power step is used as the preset power value corresponding to the next stage. The power step and the preset duration can be flexibly set.

[0059] In an illustrated embodiment, the wireless power supply device also includes a current sampling circuit 530 and a voltage sampling circuit 540. The current sampling circuit 530 is electrically connected between the transmitter 510 and the impedance calculation unit 520, and is used to continuously sample the input current of the transmitter 510 and send the sampled current value to the impedance calculation unit 520; the voltage sampling circuit 540 is electrically connected between the transmitter 510 and the impedance calculation unit 520, and is used to continuously sample the input voltage of the transmitter 510 and send the sampled voltage value to the impedance calculation unit 520.

[0060] Continue to refer Figure 5The wireless energy supply device includes a DC power supply 550, an inverter module 560, a current sampling circuit 530, a transmitter 510, a voltage sampling circuit 540, and an impedance calculation unit 520. The transmitter 510 includes a transmitting coil 511 and a power control module 512. The transmitting coil 511 is used to transmit electromagnetic energy waves to the neurostimulator, and the power control module 512 is used to increase the transmission power of the electromagnetic energy waves in stages. The first end of the current sampling circuit 530 is electrically connected to the inverter module 560, which is electrically connected to the DC power supply 550. The second end of the current sampling circuit 530 is electrically connected to the impedance calculation unit 520, and the third end of the current sampling circuit 530 is electrically connected to the transmitting coil 511. The first end of the voltage sampling circuit 540 is electrically connected to the transmitting coil 511, and the second end of the voltage sampling circuit 540 is electrically connected to the impedance calculation unit 520. The impedance calculation unit 520 is used to send a control signal to the voltage sampling circuit 540 and the current sampling circuit 530 to control the sampling process, such as configuring the sampling frequencies of the two sampling circuits to achieve time-synchronized sampling of the sampling current and the sampling voltage. The impedance calculation unit 520 is also used to receive the sampling current value and the sampling voltage value to continuously monitor the reflection impedance value corresponding to the nerve stimulator according to the time-synchronized sampling current value and the sampling voltage value and identify the impedance mutation point.

[0061] It is worth noting that the DC power supply 550, inverter module 560, voltage sampling circuit 540 and impedance calculation unit 520 in this embodiment have the same purpose as the corresponding circuits in the related art, and can all adopt the circuit design of the related art, which will not be repeated in this specification.

[0062] The pulse control methods of neurostimulators are different, and wireless energy supply devices require different parameter configuration strategies. When the pulse generator generates pulses in a constant current mode, the wireless energy supply device performs a multi-stage incremental configuration; when the pulse generator generates pulses in a constant voltage mode, it is necessary to further determine whether the target configuration value of the pulse amplitude parameter in the stimulation parameters is greater than the power-on voltage V0. If it is greater than the power-on voltage V0, the pulse amplitude parameter is first configured to a value less than V0 to calculate the load impedance estimate of the electrode contact, and then the stimulation current amplitude is configured to the target configuration value. The operating voltage estimate of the neurostimulator is calculated based on the load impedance estimate of the electrode contact and other relevant parameter values; if the target configuration value of the stimulation current amplitude is not greater than the power-on voltage V0, the stimulation current amplitude can be directly configured to the target configuration value.

[0063] In an illustrated embodiment, the impedance calculation unit 520 is further configured to determine a parameter configuration strategy based on the pulse control mode of the neurostimulator, wherein the parameter configuration strategy includes a multi-stage incremental configuration and a direct configuration, wherein:

[0064] The multi-level incremental configuration includes configuring the stimulation current amplitude in the stimulation parameters in multiple levels, wherein the configuration value of the next level is greater than the configuration value of the previous level, and when it is determined that the neurostimulator is operating at each level of parameter configuration value, executing the next level of incremental configuration until it is determined that the neurostimulator is operating at the target configuration value of the stimulation parameter;

[0065] The direct configuration includes directly configuring each stimulation parameter to a corresponding target configuration value.

[0066] Next, the wireless energy supply strategies of the impedance calculation unit in the above three scenarios are respectively described.

[0067] (1) In scenarios where the neurostimulator generates pulses at a constant current.

[0068] The impedance calculation unit 520 is also used to perform multi-level incremental configuration of the stimulation parameters of the neurostimulator. After each level of parameter configuration, the state estimation value of the neurostimulator at each level of parameter execution stage is calculated according to the reflection impedance monitoring sequence corresponding to the neurostimulator at each level of parameter execution stage, and the neurostimulator is determined to operate at each level of parameter configuration value based on the state estimation value.

[0069] When the neurostimulator operates at the power-on voltage V0, it indicates that the neurostimulator can enter the normal working mode. At this time, the wireless power supply device starts to configure the stimulation parameters and sends the parameter configuration values ​​to the neurostimulator. After receiving the parameter configuration values, the neurostimulator's pulse generator drives the RX value in a constant current manner according to the parameter configuration values ​​to generate pulses that meet the constraints of the stimulation parameter configuration values.

[0070] As mentioned above, the stimulation parameters include the frequency of the stimulation pulse, the unit stimulation time, and the stimulation current amplitude. In this scenario, the frequency and unit stimulation time parameters are not affected by the operating voltage of the neurostimulator. Therefore, in actual applications, the frequency and unit stimulation time can be directly set to the target value. The current amplitude generated by the pulse generator is related to the operating voltage of the neurostimulator. When the operating voltage is sufficient, the current amplitude generated by the pulse generator can reach the configured value. When the operating voltage is insufficient, the current amplitude generated by the pulse generator cannot reach the configured value. It is necessary to increase the transmission power of the electromagnetic wave to make the operating voltage of the neurostimulator reach its required value. Therefore, the stimulation current amplitude needs to be configured in multiple levels.

[0071] refer to Figure 6It can be seen that the reflected impedance monitoring sequence corresponding to each parameter execution stage presents a periodically alternating high impedance state and low impedance state. Therefore, the impedance calculation unit 520 can calculate at least one of the output pulse frequency estimate, output pulse width estimate and output pulse interval estimate of each parameter execution stage according to the impedance change of the reflected impedance monitoring sequence corresponding to each parameter execution stage; calculate the load impedance estimate corresponding to the neural stimulation according to the reflected impedance and mutual inductance corresponding to the high impedance state in the reflected impedance monitoring sequence corresponding to each parameter execution stage, and calculate the output pulse amplitude estimate of the neural stimulator according to the working voltage estimate, the load impedance estimate and the pre-obtained standby load impedance, wherein the mutual inductance is calculated based on the reflected impedance corresponding to the initial impedance mutation point.

[0072] The high impedance state in this embodiment can be understood as the stage where the impedance value in the reflected impedance waveform increases significantly, corresponding to the stimulation state when the neurostimulator outputs a pulse; the low impedance state can be understood as the stage where the impedance value in the reflected impedance waveform drops back, corresponding to the idle state when the neurostimulator does not output a pulse. The impedance calculation unit 520 can calculate the output pulse frequency estimate based on the fluctuation period of the high impedance state and the low impedance state, calculate the output pulse width estimate based on the duration of the high impedance state in each fluctuation period, and calculate the output pulse interval estimate based on the duration of the low impedance state in each fluctuation period. Figure 6 Taking the parameter configuration execution stage shown in FIG. 5 as an example, the fluctuation period T, the duration t1 of the high impedance state, and the duration t2 of the low impedance state can be obtained based on the reflected impedance waveform in this stage. The inverse of the fluctuation period T is used as the output pulse frequency estimate, t1 is used as the output pulse width estimate, and t2 is used as the output pulse interval estimate. Since the operating voltage estimate Vs of the neurostimulator is known to the impedance calculation unit 520 at each parameter configuration stage, the real-time load impedance estimate RL of the neurostimulator can also be calculated using formula (4). Since RL = RL0 / / RI, the impedance calculation unit 520 can obtain the real-time RI value. According to Iout = Vs / RI, the output pulse amplitude estimate Iout can be calculated.

[0073] After the impedance calculation unit 520 calculates the above-mentioned pulse state estimation value, it compares the pulse state estimation value with the allowable error range of the configuration value of the corresponding stimulation parameter. If each pulse state estimation value is within the allowable error range of the corresponding stimulation parameter configuration value, it is determined that the neurostimulator is operating at each level of parameter configuration value.

[0074] If at least one of the pulse state estimation values ​​is outside the permissible error range of the corresponding stimulation parameter configuration value, the neurostimulator is determined to be not operating at each level of the parameter configuration value. If the state estimation value outside the permissible error range of the corresponding stimulation parameter configuration value is not the output pulse amplitude estimation value, for example, if the output pulse frequency estimation value is outside the permissible error range of the stimulation frequency, or if the output pulse width estimation value is outside the permissible error range of the unit stimulation time, the neurostimulator is determined to be operating abnormally, and the impedance calculation unit 520 controls the transmitter to stop transmitting the energy supply electromagnetic wave and issues an alarm. If the other state estimation values ​​are within the error allowable range of the corresponding stimulation parameter configuration value, and only the output pulse amplitude estimation value is outside the error allowable range of the stimulation current amplitude configuration value, and the output pulse amplitude estimation value is greater than the upper limit of the error allowable range, then it is determined that the neurostimulator is working abnormally, and the impedance calculation unit 520 controls the transmitter to stop sending the power supply electromagnetic wave and issues an alarm; if the output pulse amplitude estimation value is less than the lower limit of the error allowable range, then the impedance calculation unit 520 determines that the current working voltage of the neurostimulator is insufficient, and at this time, the load impedance estimation value Rcd of the electrode contact can be calculated based on the load impedance estimation value RL of the neurostimulation and the pre-obtained standby load impedance RL0, and the control unit 520 can control the load impedance Rcd of the electrode contact to stop sending the power supply electromagnetic wave and issue an alarm; The transmitter increases the transmission power of the energy supply electromagnetic wave and monitors the reflected impedance monitoring sequence after the transmission power is increased. When an impedance mutation point is identified, it determines that the neurostimulator is operating at each level of parameter configuration value, maintains the transmitter constant at the transmission power corresponding to the impedance mutation point and updates the working voltage estimate; wherein, the impedance calculation unit 520 can calculate the equivalent impedance estimate of the output pulse of the neurostimulator based on the load impedance estimate of the neurostimulation corresponding to the impedance mutation point and the pre-obtained standby load impedance; and calculates the updated working voltage estimate based on the stimulation current amplitude configuration value and the equivalent impedance estimate corresponding to each parameter execution stage.

[0075] refer to Figure 3As shown, when the calculated output pulse amplitude estimate is less than the corresponding configured stimulation current amplitude value, the neurostimulator's operating voltage is insufficient, and the pulse generator drives RX to its minimum value. The calculated RI is the estimated load impedance Rcd of the electrode contact. When the neurostimulator's operating voltage is insufficient, the impedance calculation unit 520 also sends a power-up control command to the transmitter 510. Transmitter 510 enters the next stage in response to the power-up control command and automatically enters the next stage after a preset duration until receiving a new control command from the impedance calculation unit 520. During the process of increasing the transmit power, the operating voltage of the neurostimulator changes accordingly. When the operating voltage of the neurostimulator is sufficient, the neurostimulator's load impedance estimate RL will change significantly, and accordingly, the corresponding reflected impedance of the neurostimulator will also change significantly. For example, if the impedance change exceeds 5%, the impedance calculation unit 520 can identify the impedance mutation point (i.e., the time series corresponding to the 5% change). At this time, the impedance calculation unit 520 can send a power maintenance control command to the transmitter 510. In accordance with the power maintenance control command, the transmitter 510 maintains the transmitter's transmit power constant at the transmit power corresponding to the impedance mutation point until it receives a new control command from the impedance calculation unit 520. When the impedance mutation point is identified, it indicates that the operating voltage of the neurostimulator is sufficient. At this time, the estimated output pulse amplitude of the neurostimulator should be within the error range of the configured stimulation current amplitude value. The impedance calculation unit 520 can calculate a new operating voltage estimate Vs according to Vs = RI * Iset.

[0076] Next, combine Figure 7 The complete process of wireless energy supply in this scenario is illustrated as follows. Figure 7 As shown in FIG, in a scenario where the neurostimulator generates pulses in a constant current manner, the complete energy supply process of the wireless energy supply device includes the following steps:

[0077] Step S701 , obtaining initialization data for wireless power supply, wherein the initialization data includes a power-on voltage V0 , a standby current I0 , a standby load impedance RL0 , and target configuration values ​​of stimulation parameters of the neurostimulator.

[0078] In this embodiment, the target configuration values ​​of the stimulation parameters are frequency 50 Hz, unit stimulation time 200 us, and stimulation current amplitude 2 mA. In the initial configuration stage, the frequency and unit stimulation time can be directly configured to the target configuration values ​​50 Hz and 200 us, but the configuration value of the stimulation current amplitude needs to be gradually increased from 0 mA, for example, by 0.1 mA per second. The specific increase step can be flexibly set according to actual needs.

[0079] In step S702, the transmitter increases the transmission power in stages according to the staged strategy and identifies the power-on operating point of the neurostimulator.

[0080] During the initial phase of wireless power supply, the transmitter automatically enters the initial phase and, after a preset duration, the second phase, until it receives a control command from the impedance calculation unit. As the transmit power increases, the current sampling circuit and the voltage sampling circuit synchronously sample the transmitter's input current and input voltage. The impedance calculation unit calculates the real-time reflected impedance of the neurostimulator based on the sampled current and voltage values. If a change in the reflected impedance exceeds 5%, the moment of the sudden change in the reflected impedance is used as the neurostimulator's power-on operating point. At this point, the impedance calculation unit uses the power-on voltage V0 as the estimated operating voltage Vs of the neurostimulator.

[0081] Step S703 , calculating the mutual inductance according to the reflected impedance value corresponding to the power-on operating point and maintaining the transmitter's transmission power constant at the initial impedance mutation point.

[0082] When the neurostimulator is in the power-on voltage state, the neurostimulator enters the normal working mode. At this time, the transmitting coil and the receiving coil are already in the coupled state. Referring to formula (5), it can be seen that according to the reflected impedance Zr corresponding to the power-on working point, the standby load impedance RL0, the receiving coil internal resistance Rs and the RF signal angular frequency Calculate the mutual inductance M.

[0083] Step S704: setting a configuration strategy for stimulation parameters, and sending parameter configuration values ​​to the neurostimulator according to the configuration strategy for stimulation parameters.

[0084] In one example, the configuration strategy includes directly setting the frequency to the target frequency configuration value, setting the unit stimulation time to the target stimulation time configuration value, and setting the stimulation current amplitude to increase from 0 mA to the target configuration value in steps of 0.1 mA. Therefore, the initial configuration values ​​for the stimulation frequency and unit stimulation time are the respective target values, and the initial configuration value for the stimulation current amplitude is 0.1 mA. These initial configuration values ​​of the stimulation parameters are transmitted to the neurostimulator via the communication function of the transmitting coil, causing the neurostimulator's pulse generator to generate pulses according to the initial configuration values.

[0085] Step S705: Calculate the pulse state estimation value of the neurostimulator according to the reflected impedance monitoring sequence.

[0086] The reflected impedance monitoring sequence corresponding to the parameter configuration execution phase can reflect the output pulse waveform of the neurostimulator, so the estimated value of each pulse state can be calculated based on the reflected impedance monitoring sequence.

[0087] Step S706, determining whether each pulse state estimation value is within the error allowable range of the corresponding configuration value, if each pulse state estimation value is within the error allowable range of the corresponding configuration value, executing step S707, otherwise executing step S708.

[0088] Step S707: If the configuration value of the stimulation current amplitude is already the target configuration value, the current working state is kept unchanged; otherwise, the process returns to step S704 to update the configuration value of the stimulation current amplitude.

[0089] Step S708, determine whether the pulse state estimation value outside the allowable error range is the output pulse amplitude estimation value, and whether the output pulse amplitude estimation value is less than the lower limit of the allowable error range of the configuration value of the stimulation current amplitude. If the pulse state estimation value outside the allowable error range is the output pulse amplitude estimation value, and the output pulse amplitude estimation value is less than the lower limit of the allowable error range of the configuration value of the stimulation current amplitude, execute step S709, otherwise execute step S710.

[0090] Step S709: Increase the transmit power and monitor the reflected impedance after the power increase. When the impedance mutation point is re-identified, maintain the transmitter constant at the transmit power corresponding to the new impedance mutation point, and return to step S706 after updating the estimated working voltage.

[0091] Step S710: Determine that the neurostimulator is abnormal, stop powering it, and issue an alarm.

[0092] (2) In a scenario where the neurostimulator generates pulses in a constant voltage manner and the target configuration value of the stimulation current amplitude is not greater than the power-on voltage.

[0093] The impedance calculation unit 520 is also used to directly configure the stimulation parameters of the neurostimulator, and after the parameters are configured, obtain the reflection impedance monitoring sequence corresponding to the neurostimulator in the parameter configuration execution stage, and calculate the state estimation value of the neurostimulator in the parameter execution stage according to the reflection impedance monitoring sequence.

[0094] In this scenario, since the target configuration value Vset ≤ V0 of the stimulation current amplitude, after the neurostimulator enters the normal working mode, the pulse intensity generated by the pulse generator can reach Vset. Therefore, this embodiment can directly configure each stimulation parameter to its target configuration value without the need for a multi-stage incremental configuration.

[0095] In one example, the reflected impedance monitoring sequence presents a periodically alternating high impedance state and a low impedance state, and the impedance calculation unit 520 is used to calculate at least one of the output pulse frequency estimate, the output pulse width estimate, and the output pulse interval estimate of the neural stimulator according to the impedance change of the reflected impedance monitoring sequence. The specific calculation process can refer to the calculation scheme of the relevant embodiment in the scenario, and this embodiment will not be repeated here; and, according to the reflected impedance Zr and the mutual inductance coefficient M corresponding to the high impedance state in the reflected impedance monitoring sequence, the load impedance estimate RL corresponding to the neural stimulation is calculated, and according to the load impedance estimate RL, the pre-obtained standby load impedance RL0, the power-on voltage V0 and the target configuration value Vset of the stimulation current amplitude, that is, according to the formula The load impedance estimation value Rcd of the electrode contact of the neurostimulator is calculated.

[0096] (3) In a scenario where the neurostimulator generates pulses in a constant voltage manner and the target configuration value of the stimulation current amplitude is greater than the power-on voltage.

[0097] The impedance calculation unit 520 is also used to perform multi-stage incremental configuration on the stimulation parameters of the neurostimulator, and after the primary configuration of the stimulation parameters of the neurostimulator, the primary configuration value of the stimulation current amplitude is not greater than the power-on voltage of the neurostimulator, obtain the reflection impedance monitoring sequence corresponding to the neurostimulator in the primary configuration execution stage and calculate the load impedance estimation value of the electrode contact of the neurostimulator according to the reflection impedance monitoring sequence; after calculating the load impedance estimation value of the electrode contact of the neurostimulator, configure the stimulation parameters to the target configuration value, control the transmitter to increase the transmission power of the power supply electromagnetic wave and monitor the reflection impedance monitoring sequence after the transmission power is increased, and when an impedance mutation point is identified, determine that the neurostimulator is operating at the target configuration value of the stimulation parameter, maintain the transmitter constant at the transmission power corresponding to the impedance mutation point and update the working voltage estimation value.

[0098] As previously described, upon identifying the initial impedance mutation point, the wireless energy supply device determines that the operating voltage of the neurostimulator is the power-on voltage. At this point, the wireless energy supply device stops increasing the transmit power to maintain the neurostimulator at the power-on voltage. When the pulse generator generates pulses in a constant voltage manner, the target configuration value Vset for the stimulation current amplitude is greater than V0, so the pulse intensity generated by the pulse generator cannot reach Vset. Therefore, this embodiment requires a multi-stage incremental configuration for the stimulation current amplitude.

[0099] In this scenario, the multi-level incremental configuration may include a primary configuration and a final configuration, wherein the frequency parameter and the unit stimulation time parameter in the stimulation parameters can be directly configured as their respective target configuration values, while the stimulation current amplitude needs to go through the primary configuration and the final configuration, wherein the primary configuration value of the stimulation current amplitude is not greater than the power-on voltage V0 of the neurostimulator, for example, it can be set to 0.5V0, and the final configuration is the target configuration value Vset. Among them, the calculation scheme of the load impedance estimation value Rcd under the primary configuration can refer to the calculation scheme of Rcd in Scenario 2, and this embodiment will not be repeated here. After the impedance calculation unit 520 calculates the load impedance estimate Rcd, it configures the stimulation current amplitude to Vset. At this time, the pulse generator drives RX to the minimum value so that the operating voltage of the neurostimulator (i.e., the power-on voltage V0) is approximately equal to the load resistance acting entirely on the electrode contacts. Since the current operating voltage of the neurostimulator is lower than Vset, the neurostimulator is not operating at the parameter configuration value. In this case, the impedance calculation unit 520 controls the transmitter 510 to increase the transmission power. During the transmission power increase process, if the operating voltage of the neurostimulator is sufficient, the corresponding reflected impedance of the neurostimulator will change significantly, and the impedance calculation unit 520 can identify the impedance mutation point. When the impedance mutation point is identified, the impedance calculation unit 520 controls the transmitter 510 to stop increasing the transmission power and controls the transmitter to keep the transmission power constant at the transmission power corresponding to the impedance mutation point. At this time, the operating voltage estimate of the neurostimulator Vs = RI * Iset, Iset = Vset / Rcd can be calculated.

[0100] The present application provides a wireless power supply device with a state prediction function through the above-mentioned embodiments. The wireless power supply device monitors the reflected impedance monitoring sequence of the neurostimulator in the parameter configuration execution stage through a current sampling circuit, a voltage sampling circuit and an impedance calculation unit. Since the reflected impedance monitoring sequence can reflect the output pulse waveform of the neurostimulator, the wireless power supply device can calculate the state estimation value of the actual working parameter of the neurostimulator according to the reflected impedance monitoring sequence, without the need for the neurostimulator to feedback the state value of the working parameter to the wireless functional device in real time, so that the neurostimulator does not need to be configured with a sampling circuit and a special wireless communication circuit, which helps to achieve a miniaturized design of the neurostimulator; and the neurostimulator state estimation value is obtained by the wireless power supply device in real time according to the reflected impedance monitoring sequence, and does not require end-to-end wireless transmission or encoding and decoding. Therefore, it has the characteristic of short response time, so that the wireless power supply device can quickly supply energy and improve the efficiency of wireless power supply.

[0101] An embodiment of the present application also provides a wireless power supply method for a neurostimulator, which is applied to the wireless power supply device described in any of the above embodiments. Figure 8This is a flow chart of a wireless energy supply method for a neurostimulator according to an exemplary embodiment of the present specification. Figure 8 As shown, the wireless energy supply method includes the following steps:

[0102] Step S810, transmitting energy supply electromagnetic waves to the neurostimulator through the transmitter and increasing the transmission power of the energy supply electromagnetic waves;

[0103] Step S820, continuously monitoring the reflected impedance corresponding to the neurostimulator according to the input current and input voltage of the transmitter and identifying an impedance mutation point;

[0104] Step S830, when an initial impedance mutation point is identified, maintaining the transmitter's transmission power constant at the corresponding initial impedance mutation point and determining the previously obtained power-on voltage of the neurostimulator as the estimated operating voltage of the neurostimulator; and executing parameter configuration and calculating the estimated state value of the neurostimulator according to the reflected impedance monitoring sequence corresponding to the neurostimulator during the parameter configuration execution phase;

[0105] Step S840: Control the transmission power of the energy supply electromagnetic wave according to the state estimation value.

[0106] In an illustrated embodiment, when the initial impedance mutation point is identified, the method 800 further includes: determining a parameter configuration strategy based on a pulse control method of the neurostimulator, wherein the parameter configuration strategy includes a multi-stage incremental configuration and a direct configuration, wherein:

[0107] The multi-level incremental configuration includes performing multi-level configuration of the stimulation current amplitude in the stimulation parameter, wherein the configuration value of the next level is greater than the configuration value of the previous level, and when it is determined that the neurostimulator is operating at each level parameter configuration value, performing the next level incremental configuration until it is determined that the neurostimulator is operating at the target configuration value of the stimulation parameter;

[0108] The direct configuration includes directly configuring each stimulation parameter to a corresponding target configuration value.

[0109] In an illustrated embodiment, when the neurostimulator generates pulses in a constant current manner, parameter configuration is performed in step S830 and a state estimation value of the neurostimulator is calculated according to a reflection impedance monitoring sequence corresponding to the neurostimulator in the parameter configuration execution stage, including: performing multi-level incremental configuration on the stimulation parameters of the neurostimulator, and after each level of parameter configuration, calculating the state estimation value of the neurostimulator in each level of parameter execution stage according to the reflection impedance monitoring sequence corresponding to the neurostimulator in each level of parameter configuration execution stage, and determining that the neurostimulator is operating at each level of parameter configuration value based on the state estimation value.

[0110] In an illustrated embodiment, the reflected impedance monitoring sequence corresponding to each parameter execution stage presents a periodically alternating high impedance state and low impedance state, and the state estimation value includes a pulse state estimation value. The state estimation value of the neurostimulator at each parameter execution stage is calculated according to the reflected impedance monitoring sequence corresponding to each parameter configuration execution stage, including: calculating at least one of the output pulse frequency estimation value, the output pulse width estimation value and the output pulse interval estimation value at each parameter configuration execution stage according to the impedance change of the reflected impedance monitoring sequence corresponding to each parameter configuration execution stage; calculating the load impedance estimation value corresponding to the neurostimulation according to the reflected impedance and mutual inductance corresponding to the high impedance state in the reflected impedance monitoring sequence corresponding to each parameter configuration execution stage, and calculating the output pulse amplitude estimation value of the neurostimulator according to the working voltage estimation value, the load impedance estimation value and the pre-obtained standby load impedance, wherein the mutual inductance coefficient is calculated based on the reflected impedance corresponding to the initial impedance mutation point.

[0111] In an illustrated embodiment, the state estimation value also includes a load impedance estimation value of the electrode contact, and method 800 also includes: when the output pulse amplitude estimation value in each level parameter configuration execution stage is less than the lower limit of the error allowable range of the configuration value of the corresponding stimulation current amplitude, the load impedance estimation value of the electrode contact is calculated based on the load impedance estimation value of the neural stimulation and the pre-obtained standby load impedance, the transmitter is controlled to increase the transmission power of the power supply electromagnetic wave and the reflected impedance monitoring sequence after the transmission power is increased, and when an impedance mutation point is identified, the neural stimulator is determined to operate at each level parameter configuration value, the transmitter is maintained constant at the transmission power corresponding to the impedance mutation point and the operating voltage estimation value is updated.

[0112] In an illustrated embodiment, the updating of the estimated working voltage includes: calculating the equivalent impedance estimated value of the output pulse of the neural stimulator based on the load impedance estimated value of the neural stimulation corresponding to the impedance mutation point and the pre-obtained standby load impedance; and calculating the updated estimated working voltage value based on the stimulation current amplitude configuration value and the equivalent impedance estimated value corresponding to each parameter execution stage.

[0113] In an illustrated embodiment, when the neurostimulator generates pulses in a constant voltage manner and the target configuration value of the stimulation current amplitude in the stimulation parameters is not greater than the power-on voltage of the neurostimulator, parameter configuration is performed in step S830 and a state estimation value of the neurostimulator is calculated according to the reflection impedance monitoring sequence corresponding to the neurostimulator in the parameter configuration execution stage, including: directly configuring the stimulation parameters of the neurostimulator, and obtaining the reflection impedance monitoring sequence corresponding to the neurostimulator in the parameter configuration execution stage after the parameter configuration, the reflection impedance monitoring sequence presenting a periodically alternating high impedance state and a low impedance state, calculating at least one of the output pulse frequency estimation value, the output pulse width estimation value and the output pulse interval estimation value of the neurostimulator according to the impedance change of the reflection impedance monitoring sequence; calculating the load impedance estimation value corresponding to the neurostimulation according to the reflection impedance corresponding to the high impedance state in the reflection impedance monitoring sequence and the mutual inductance coefficient, and calculating the load impedance estimation value of the electrode contact of the neurostimulator according to the load impedance estimation value, the pre-obtained standby load impedance, the power-on voltage and the target configuration value of the stimulation current amplitude, wherein the mutual inductance coefficient is calculated according to the reflection impedance corresponding to the initial impedance mutation point.

[0114] In an illustrated embodiment, when the neurostimulator generates pulses in a constant voltage manner and the target configuration value of the stimulation current amplitude in the stimulation parameters is greater than the power-on voltage of the neurostimulator, parameter configuration is performed in step S830 and a state estimation value of the neurostimulator is calculated based on a reflection impedance monitoring sequence corresponding to the neurostimulator during the parameter configuration execution phase, including: performing multi-stage incremental configuration on the stimulation parameters of the neurostimulator, and after the primary configuration of the stimulation parameters of the neurostimulator is performed, the primary configuration value of the stimulation current amplitude is not greater than the power-on voltage of the neurostimulator, obtaining a reflection impedance monitoring sequence corresponding to the neurostimulator during the primary configuration execution phase and calculating a load impedance estimation value of the electrode contact of the neurostimulator based on the reflection impedance monitoring sequence; configuring the stimulation parameters to target configuration values, controlling the transmitter to increase the transmission power of the energy supply electromagnetic wave and monitoring the reflection impedance monitoring sequence after the transmission power is increased, and when an impedance mutation point is identified, determining that the neurostimulator is operating at the target configuration value of the stimulation parameters, maintaining the transmission power of the transmitter constant at the impedance mutation point and updating the working voltage estimation value.

[0115] In an illustrated embodiment, in step S810, power supply electromagnetic waves are transmitted to the neurostimulator through the transmitter and the transmission power of the power supply electromagnetic waves is increased, including: increasing the transmission power according to a phased strategy, the phased strategy includes at least two power increase stages, each stage corresponds to a preset power value and a preset duration, the preset power value corresponding to the next stage is higher than the preset power value corresponding to the previous stage, the transmitter automatically enters the initial stage and automatically switches to the next stage after completing the previous stage, and performs stage switching or maintenance based on the control of the impedance calculation unit.

[0116] Figure 9 This is a schematic diagram of an electronic device according to an exemplary embodiment of this specification. Figure 9 At the hardware level, the device includes a processor 902, an internal bus 904, a network interface 906, a memory 908, a hardware acceleration device 910, and a non-volatile memory 912. Of course, it may also include hardware required for other functions. One or more embodiments of the present application can be implemented based on software, such as the processor 902 reading the corresponding computer program from the non-volatile memory 912 into the memory 908 and then running it. Of course, in addition to software implementation, one or more embodiments of the present application do not exclude other implementation methods, such as logic devices or a combination of software and hardware, etc., that is, the execution subject of the above-mentioned processing flow is not limited to each logic unit, but can also be hardware or logic devices.

[0117] Corresponding to the above-mentioned embodiment of the wireless power supply method, this application also provides a corresponding device embodiment. Figure 10 The wireless energy supply device can be applied to the wireless energy supply equipment as described in any of the above embodiments. Figure 9 When the electronic device shown is the above-mentioned wireless power supply device, the wireless power supply device can be specifically applied to the following: Figure 9 The electronic device shown in the figure is used to implement the technical solution of the present application. The wireless energy supply device may include a power control unit 1001, a first calculation unit 1002 and a second calculation unit 1003, wherein:

[0118] A power control unit 1001 is configured to transmit energy supply electromagnetic waves to the neurostimulator via a transmitter and to increase the transmission power of the energy supply electromagnetic waves;

[0119] A first calculation unit 1002 is configured to continuously monitor the reflected impedance corresponding to the neurostimulator according to the input current and input voltage of the transmitter and identify an impedance mutation point;

[0120] The second calculation unit 1003 is used to maintain the transmission power of the transmitter constant at the corresponding initial impedance mutation point and determine the pre-acquired power-on voltage of the neurostimulator as the estimated working voltage of the neurostimulator when the initial impedance mutation point is identified; and to execute parameter configuration and calculate the state estimation value of the neurostimulator according to the corresponding reflection impedance monitoring sequence of the neurostimulator in the parameter configuration execution stage, and control the transmission power of the power supply electromagnetic wave according to the state estimation value.

[0121] For the device embodiments, since they basically correspond to the method embodiments, the relevant parts can be referred to the partial description of the method embodiments. The device embodiments described above are merely schematic, wherein the units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they may be located in one place, or they may be distributed on multiple network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the present application scheme. A person of ordinary skill in the art can understand and implement it without paying any creative work.

[0122] Accordingly, the present application also provides a computer-readable storage medium on which a computer program is stored. When the computer program is executed by a processor, the method described in any of the above embodiments is implemented.

[0123] Accordingly, an embodiment of the present application further provides a computer program product, which is configured to execute the method described in any of the above embodiments.

[0124] The systems, devices, modules, or units described in the above embodiments may be implemented by computer chips or entities, or by products having certain functions. A typical implementation device is a computer, which may be in the form of a personal computer, laptop computer, cellular phone, camera phone, smartphone, personal digital assistant, media player, navigation device, email transceiver, game console, tablet computer, wearable device, or any combination of these devices.

[0125] In a typical configuration, a computer includes one or more processors (CPU), input / output interfaces, network interfaces, and memory.

[0126] Memory may include non-permanent storage in a computer-readable medium, in the form of random access memory (RAM) and / or non-volatile memory, such as read-only memory (ROM) or flash RAM. Memory is an example of a computer-readable medium.

[0127] Computer-readable media include permanent and non-permanent, removable and non-removable media that can be implemented by any method or technology to store information. Information can be computer-readable instructions, data structures, program modules, or other data. Examples of computer storage media include, but are not limited to, phase change memory (PRAM), static random access memory (SRAM), dynamic random access memory (DRAM), other types of random access memory (RAM), read-only memory (ROM), electrically erasable programmable read-only memory (EEPROM), flash memory or other memory technologies, compact disc read-only memory (CD-ROM), digital versatile disc (DVD) or other optical storage, magnetic cassettes, magnetic disk storage, quantum memory, graphene-based storage media or other magnetic storage devices, or any other non-transmission media that can be used to store information that can be accessed by a computing device. As defined herein, computer-readable media does not include transitory computer-readable media such as modulated data signals and carrier waves.

[0128] It should also be noted that the terms "comprises," "includes," or any other variations thereof are intended to encompass non-exclusive inclusion, such that a process, method, commodity, or apparatus that includes a series of elements includes not only those elements but also other elements not explicitly listed, or includes elements inherent to such process, method, commodity, or apparatus. In the absence of further limitations, an element defined by the phrase "comprises a ..." does not exclude the presence of other identical elements in the process, method, commodity, or apparatus that includes the element.

[0129] The foregoing description describes specific embodiments of the present application. Other embodiments are within the scope of the appended claims. In some cases, the actions or steps recited in the claims can be performed in an order different from that described in the embodiments and still achieve the desired results. Furthermore, the processes depicted in the accompanying drawings do not necessarily require the specific order shown or the sequential order to achieve the desired results. In certain embodiments, multitasking and parallel processing are also possible or may be advantageous.

Claims

1. A wireless energy supply device for a neurostimulator, characterized in that: include: A transmitter, configured to transmit energy supply electromagnetic waves to the neurostimulator and increase the transmission power of the energy supply electromagnetic waves; an impedance calculation unit, the impedance calculation unit being electrically connected to the transmitter, and configured to monitor the reflected impedance corresponding to the neurostimulator based on the input current and input voltage of the transmitter, and, upon identifying an initial impedance mutation point, maintain the transmitter at a constant transmission power corresponding to the initial impedance mutation point, and determine the pre-acquired power-on voltage of the neurostimulator as an estimated working voltage of the neurostimulator, and execute parameter configuration and calculate a state estimation value of the neurostimulator based on a reflected impedance monitoring sequence corresponding to the neurostimulator during a parameter configuration execution phase, and control the transmission power of the energy supply electromagnetic wave based on the state estimation value; The state estimation value includes a pulse state estimation value, an operating voltage estimation value, and a load impedance estimation value of an electrode contact, wherein the pulse state estimation value includes at least one of an output pulse frequency estimation value, an output pulse width estimation value, an output pulse interval estimation value, and an output pulse amplitude estimation value.

2. The wireless energy supply device according to claim 1, characterized in that: The impedance calculation unit is further configured to determine a parameter configuration strategy according to a pulse control mode of the neurostimulator, wherein the parameter configuration strategy includes a multi-stage incremental configuration and a direct configuration, wherein: The direct configuration includes directly configuring each stimulation parameter to a corresponding target configuration value; The multi-level incremental configuration includes multi-level configuration of the stimulation current amplitude in the stimulation parameters, and the next level configuration value is greater than the previous level configuration value. When it is determined that the neurostimulator is operating at each level parameter configuration value, the next level incremental configuration is executed until it is determined that the neurostimulator is operating at the target configuration value of each stimulation parameter.

3. The wireless energy supply device according to claim 2, characterized in that: When the neurostimulator generates pulses in a constant current manner, the impedance calculation unit is further configured to: The stimulation parameters of the neurostimulator are configured in multiple levels of increments. After each level of parameter configuration, the state estimation value of the neurostimulator at each level of parameter execution stage is calculated according to the reflection impedance monitoring sequence corresponding to the neurostimulator at each level of parameter configuration execution stage, and the neurostimulator is determined to operate at each level of parameter configuration value based on the state estimation value.

4. The wireless energy supply device according to claim 3, characterized in that: The reflected impedance monitoring sequence corresponding to each parameter execution stage presents a periodically alternating high impedance state and low impedance state, and the impedance calculation unit is further used to: Calculating at least one of an output pulse frequency estimation value, an output pulse width estimation value, and an output pulse interval estimation value in each parameter configuration execution stage according to an impedance change of a reflected impedance monitoring sequence corresponding to each parameter configuration execution stage; The load impedance estimate corresponding to the neural stimulation is calculated based on the reflected impedance and mutual inductance corresponding to the high impedance state in the reflected impedance monitoring sequence corresponding to each level of parameter configuration execution phase, and the output pulse amplitude estimate of the neural stimulator is calculated based on the working voltage estimate, the load impedance estimate and the pre-obtained standby load impedance, wherein the mutual inductance is calculated based on the reflected impedance corresponding to the initial impedance mutation point.

5. The wireless energy supply device according to claim 4, characterized in that: The impedance calculation unit is further configured to: When the output pulse amplitude estimate value in each level parameter configuration execution stage is less than the lower limit of the error allowable range of the corresponding stimulation current amplitude configuration value, the load impedance estimate value of the electrode contact is calculated based on the load impedance estimate value of the neural stimulation and the pre-obtained standby load impedance, the transmitter is controlled to increase the transmission power of the power supply electromagnetic wave and the reflected impedance monitoring sequence after the transmission power is increased is monitored, and when the impedance mutation point is identified, the neural stimulator is determined to operate at each level parameter configuration value, the transmitter is maintained constant at the transmission power corresponding to the impedance mutation point and the operating voltage estimate is updated.

6. The wireless energy supply device according to claim 5, characterized in that: The impedance calculation unit is further configured to: Calculating an equivalent impedance estimate of the neurostimulator during output pulses based on the load impedance estimate of the neurostimulation corresponding to the impedance mutation point and a pre-obtained standby load impedance; The updated estimated working voltage value is calculated according to the stimulation current amplitude configuration value and the equivalent impedance estimated value corresponding to each parameter execution stage.

7. The wireless energy supply device according to claim 2, characterized in that: When the neurostimulator generates pulses in a constant voltage manner and a target configuration value of the stimulation current amplitude in the stimulation parameters is not greater than a power-on voltage of the neurostimulator, the impedance calculation unit is further configured to: directly configuring stimulation parameters of the neurostimulator, and after the parameter configuration, obtaining a reflection impedance monitoring sequence corresponding to the neurostimulator during the parameter configuration execution phase, wherein the reflection impedance monitoring sequence presents a periodically alternating high impedance state and low impedance state, and calculating at least one of an output pulse frequency estimate, an output pulse width estimate, and an output pulse interval estimate of the neurostimulator based on impedance changes in the reflection impedance monitoring sequence; The load impedance estimation value corresponding to the neural stimulation is calculated based on the reflected impedance and mutual inductance coefficient corresponding to the high impedance state in the reflected impedance monitoring sequence, and the load impedance estimation value of the electrode contact of the neural stimulator is calculated based on the load impedance estimation value, the pre-obtained standby load impedance, the power-on voltage and the target configuration value of the stimulation current amplitude, wherein the mutual inductance coefficient is calculated based on the reflected impedance corresponding to the initial impedance mutation point.

8. The wireless energy supply device according to claim 2, characterized in that: When the neurostimulator generates pulses in a constant voltage manner and a target configuration value of the stimulation current amplitude in the stimulation parameters is greater than a power-on voltage of the neurostimulator, the impedance calculation unit is further configured to: Performing multi-stage incremental configuration on the stimulation parameters of the neurostimulator, and after the primary configuration of the stimulation parameters of the neurostimulator, the primary configuration value of the stimulation current amplitude is not greater than the power-on voltage of the neurostimulator, obtaining a reflection impedance monitoring sequence corresponding to the neurostimulator during the primary configuration execution phase, and calculating a load impedance estimation value of the electrode contact of the neurostimulator based on the reflection impedance monitoring sequence; The stimulation parameters are configured as target configuration values, the transmitter is controlled to increase the transmission power of the power supply electromagnetic wave and the reflected impedance monitoring sequence after the transmission power is increased is monitored. When an impedance mutation point is identified, the neurostimulator is determined to operate at the target configuration value of the stimulation parameters, the transmission power of the transmitter is maintained constant at the transmission power corresponding to the impedance mutation point and the operating voltage estimation value is updated.

9. The wireless energy supply device according to claim 1, characterized in that: The transmitter is used to: The transmission power is increased according to a phased strategy, the phased strategy includes at least two power increase stages, each stage corresponds to a preset power value and a preset duration, the preset power value corresponding to the next stage is higher than the preset power value corresponding to the previous stage, the transmitter automatically enters the initial stage and automatically switches to the next stage after completing the previous stage, and the stage switching or maintenance is performed based on the control of the impedance calculation unit.

10. The wireless energy supply device according to any one of claims 1 to 9, characterized in that: Also includes: a current sampling circuit, electrically connected between the transmitter and the impedance calculation unit, for continuously sampling the input current of the transmitter and sending the sampled current value to the impedance calculation unit; The voltage sampling circuit is electrically connected between the transmitter and the impedance calculation unit, and is used for continuously sampling the input voltage of the transmitter and sending the sampled voltage value to the impedance calculation unit.

11. A wireless energy supply method for a neurostimulator, characterized in that: Applied to the wireless energy supply device according to any one of claims 1 to 10, the method comprises: transmitting energy supply electromagnetic waves to the neurostimulator through a transmitter and increasing the transmission power of the energy supply electromagnetic waves; monitoring the reflected impedance corresponding to the neurostimulator according to the input current and input voltage of the transmitter and identifying the impedance mutation point; When an initial impedance mutation point is identified, maintaining the transmitter constant at a transmission power corresponding to the initial impedance mutation point and determining the previously obtained power-on voltage of the neurostimulator as an estimated operating voltage of the neurostimulator; and executing parameter configuration and calculating a state estimate of the neurostimulator according to a reflected impedance monitoring sequence corresponding to the neurostimulator during the parameter configuration execution phase. The transmission power of the energy supply electromagnetic wave is controlled according to the state estimation value.

12. An electronic device, characterized in that: include: processor; a memory for storing processor-executable instructions; The processor is configured to implement the method as claimed in claim 11.

13. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the method according to claim 11 is implemented.

14. A computer program product comprising a computer program / instructions, characterized in that When the computer program / instructions are executed by a processor, the method according to claim 11 is implemented.

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