A POCT microfluidic detection cartridge automatic assembly production line and production process method

Abstract

The present invention discloses an automatic assembly production line and production process for a POCT microfluidic test cartridge, comprising a circulating conveyor line for conveying materials in the X-direction, a carrier for circulating on the circulating conveyor line, a base and chamber bonding unit, a base film thermal bonding unit, a valve body assembly station, a chamber film bonding unit, a microsphere pre-embedding and cartridge top cover bonding unit, a reagent pre-embedding unit, a top cover film bonding unit, a filter element assembly unit, and a cover closing and unloading unit. The present invention enables the automatic bonding and assembly of the test cartridge base, chamber, and top cover, the automatic thermal bonding of the functional membrane on the test cartridge, and the pre-embedding production and intelligent detection of reagents and microspheres, greatly improving production efficiency.

Description

Technical Field

[0001] The present invention belongs to the technical field of automation equipment, and in particular relates to an automatic assembly production line and a production process method for a POCT microfluidic detection cartridge. Background Art

[0002] With the development of fields such as biochemistry and medical diagnostics, the requirements for the precision, speed, and efficiency of sample processing and analysis are becoming increasingly stringent. As an emerging platform for sample processing and analysis, microfluidic chip technology has attracted widespread attention due to its advantages such as small size, low sample consumption, fast reaction speed, parallel processing, and disposable design.

[0003] However, there are still many deficiencies in the production methods of microfluidic detection boxes in the prior art. For example, patent 202410966827.1 discloses a detection box, which includes a base, a warehouse body and a top cover, and is equipped with a valve assembly under the base. However, there is currently no complete automated production line that can achieve efficient automatic assembly of the detection box product. The existing production methods mostly rely on manual operation or semi-automatic processing of some processes, resulting in low production efficiency and difficulty in ensuring product consistency and quality stability. In addition, the assembly process of the detection box involves multiple complex processes, including bonding the base and the warehouse body, precise pasting of the membrane material, pre-embedding of microspheres and reagents, bonding and film application of the top cover, assembly of the filter element and the final covering operation. These processes have extremely high requirements for positioning accuracy and operational consistency, and traditional production methods are difficult to meet these requirements. Therefore, there is an urgent need for a new POCT microfluidic detection box automatic assembly production line and production process method to solve the above technical problems.

[0004] The present invention provides automated transfer and precise positioning for the assembly of test cassettes by providing a circulating conveyor line in conjunction with a carrier structure. Along the conveyor line, a base and chamber bonding unit, a base film thermal bonding unit, a valve body assembly station, a chamber film bonding unit, a microsphere pre-embedding and top cover bonding unit, a reagent pre-embedding unit, a top cover film bonding unit, a filter element assembly unit, and a cover closing and unloading unit are sequentially arranged. This enables a series of operations such as automated feeding, assembly, bonding, film bonding, reagent pre-embedding, and intelligent detection of each component of the test cassette, significantly improving production efficiency. Furthermore, the present invention is highly flexible and versatile, and its functions can be adjusted according to the specific product structure to meet the production needs of different products, thereby achieving intelligent and flexible production. Summary of the Invention

[0005] This paper addresses the low production efficiency and insufficient automation of existing POCT microfluidic test cartridges by proposing a highly efficient, intelligent, and flexible automated assembly line and production process. By incorporating a circulating conveyor line and a carrier structure, the production line combines multiple functional units to achieve automated assembly and intelligent testing of test cartridges.

[0006] The present invention achieves the above-mentioned object through the following technical solution: an automatic assembly production line for POCT microfluidic detection cartridges, comprising a circulating conveyor line and a carrier conveyed on the circulating conveyor line; along the circulating conveyor line are sequentially arranged:

[0007] A base-to-bin bonding unit bonds the base and the bin together to form a first assembly, and includes a bin feeding mechanism and a base feeding mechanism, a first handling robot for handling the bin and the base, a first turntable within the working range of the first handling robot, and a first bonding mechanism and a first handling mechanism disposed around the first turntable;

[0008] A base film laminating and thermal bonding unit, which adheres the first film material to the base and includes a first film material supply mechanism, a first film laminating mechanism, and a thermal bonding mechanism located above the circulating conveyor line;

[0009] The valve body assembly station manually assembles the valve body assembly onto the first assembly to obtain a second assembly;

[0010] a bin body film pasting unit for pasting the second film material and / or the third film material on the bin body;

[0011] A microsphere pre-embedded and cartridge top cover bonding unit is configured to place microspheres in the bin body and bond the top cover to the top of the bin body to obtain a third assembly; the unit includes a microsphere feeding mechanism and a microsphere transport mechanism, a top cover feeding mechanism and a second turntable, a second transport robot for transporting materials between the top cover feeding mechanism, the carrier, and the second turntable, a second bonding mechanism disposed adjacent to the second turntable, and a second transport mechanism for removing the third assembly from the second turntable and placing it in the carrier.

[0012] A reagent pre-embedding unit for pre-embedding reagents in a set area within the bin;

[0013] a top cover film pasting unit for pasting a fourth film material on the top cover;

[0014] A filter element assembly unit, which inserts the filter element into the designated hole of the top cover and includes a filter element feeding mechanism and a filter element transport mechanism;

[0015] The cover closing and unloading unit converts the top cover in the open state into the closed state to obtain the detection box, and takes the detection box out of the carrier for unloading. The unit includes a cover pressing station, a cover closing guide that guides and constrains the top cover to the closed state when the carrier moves to the cover pressing station, a cover pressing mechanism arranged above the cover pressing station, and a third transport mechanism that takes the detection box out of the carrier at the cover pressing station.

[0016] Furthermore, the carrier is provided with a first carrying slot and a second carrying slot, the first handling robot clamps the warehouse body and places it in an upside-down state in the first carrying slot, then clamps the base and assembles it on the warehouse body in the first carrying slot, and then clamps the base and the warehouse body together and places them in the first turntable; the first handling mechanism takes out the first assembly from the first turntable and places it in an upside-down state in the first carrying slot; at the valve body assembly station, the second assembly obtained after the valve body assembly is manually assembled is placed back in the second carrying slot in a front state.

[0017] Furthermore, a first camera is provided within the working range of the first transport robot, and the first transport robot clamps the base to the top of the first camera for positioning and then assembles it to the warehouse body located in the carrier; a second camera is provided within the working range of the first transport mechanism, and the first transport mechanism clamps the first combination formed by bonding the base and the warehouse body to the top of the second camera for bonding quality inspection, and then puts the first combination back into the carrier located on the circulating conveyor line.

[0018] Furthermore, the movable end of the first handling robot is provided with a first clamping claw assembly for clamping the warehouse body and the first combination and a first adsorption plate for adsorbing the base; a plurality of jigs for carrying the first combination are provided at equal angles on the first turntable.

[0019] Furthermore, a third camera is provided within the working range of the first film-laminating mechanism, and the first film-laminating mechanism absorbs the first film material and moves it above the third camera for positioning before pasting it to the designated position of the base; the first film-laminating mechanism includes a first YZ transfer module and a second adsorption plate provided at the movable end of the first YZ transfer module; the thermal bonding mechanism includes a third cylinder and a hot pressing plate driven by the third cylinder to move up and down.

[0020] Furthermore, the warehouse film pasting unit includes a second film material supply mechanism and a third film material supply mechanism, a second film pasting mechanism that absorbs the film material at the output ends of the second film material supply mechanism and the third film material supply mechanism and pastes it to a designated position on the warehouse body, and a fourth camera arranged within the working range of the second film pasting mechanism.

[0021] Furthermore, the second film-laminating mechanism includes a first XYZ transfer module, a first support plate arranged at the movable end of the first XYZ transfer module, a first driving member fixed on the first support plate, a first rotating plate driven by the first driving member to rotate around the Z axis, and a third adsorption plate elastically floating up and down on the first rotating plate.

[0022] Furthermore, the microsphere pre-embedding and card box top cover bonding unit includes a microsphere placing station, a top cover assembly station and a top cover bonding station arranged along the circulating conveying line; the microsphere feeding mechanism and the microsphere transporting mechanism are arranged at the microsphere placing station; the second turntable, the second bonding mechanism and the second transporting mechanism are arranged at the top cover bonding station; the top cover feeding mechanism and the second transport robot are arranged at the top cover assembly station; the movable end of the second transport robot is provided with a second clamping claw assembly for clamping the top cover and a third clamping claw assembly for clamping the top cover and the second combination; a fifth camera is provided within the working range of the second transport robot, and after the second transport robot clamps the top cover, it moves to the top of the fifth camera for positioning and then assembles it to the top of the warehouse body in the second combination.

[0023] Furthermore, the microsphere pre-embedded and card box top cover bonding unit also includes an airtight detection mechanism, which is arranged above the circulating conveyor line and downstream of the top cover bonding station; the airtight detection mechanism includes a lifting module that lifts the carrier upward from the circulating conveyor line, an airtight plate located directly above the lifting module, a fourth cylinder that drives the airtight plate to move up and down, and an airtight detection system connected to the air path of the airtight plate.

[0024] Furthermore, the top cover film pasting unit includes a fourth film material supply mechanism, a third film pasting mechanism that absorbs the film material at the output end of the fourth film material supply mechanism and pastes it to a designated position on the top cover, and a sixth camera arranged within the working range of the third film pasting mechanism;

[0025] The third film pasting mechanism includes a second XYZ transfer module, a third support plate arranged at the movable end of the second XYZ transfer module, and a first film pasting assembly fixed on the third support plate; the first film pasting assembly includes a third driving member fixed on the third support plate, a second rotating plate driven by the third driving member to rotate around the Z axis, and a fifth adsorption plate elastically floating up and down on the second rotating plate.

[0026] Furthermore, the top cover film pasting unit also includes a fifth film material supply mechanism arranged side by side with the fourth film material supply mechanism; a second film pasting assembly is also arranged on the third support plate; the second film pasting assembly includes a fifth cylinder fixed on the third support plate, a fourth support plate moved up and down by the fifth cylinder, a sixth cylinder fixed on the fourth support plate, and a sixth adsorption plate driven by the sixth cylinder to flip around the X-axis.

[0027] Furthermore, a seventh camera is provided above the circulating conveyor line and downstream of the third film pasting mechanism to detect whether the film material position on the top cover is pasted correctly.

[0028] Furthermore, the filter element assembly unit includes a filter element feeding mechanism and a filter element transporting mechanism that sucks the filter element from the filter element feeding mechanism and inserts it into the designated hole of the top cover; the filter element transporting mechanism includes a third XYZ transfer module and a suction nozzle arranged at the movable end of the third XYZ transfer module.

[0029] Furthermore, the top cover includes a first top cover body and a second top cover body, the first top cover body is fixed on the top of the warehouse body, and the second top cover body is rotatably connected to the first top cover body; the covering guide is a rib structure and has a head end A and a tail end B, the tail end B extends to the covering station, and a flat plate limiting part is provided at the tail end B; in the initial state, the second top cover body is in an open state; the head end A is located on the rear side of the warehouse body, and the flat plate limiting part is located above the top cover; in the process of the carrier moving to the covering station, the guide ribs between the head end A and the tail end B gradually constrain the second top cover body from the open state to the covering state, and at the covering station, the second top cover body is restricted to the covering state by the flat plate limiting part; the covering mechanism includes a seventh cylinder and a covering rod driven by the seventh cylinder to move up and down, and the flat plate limiting part is provided with an avoidance through-hole for the covering rod to pass through.

[0030] Another object of the present invention is to provide a method for automatically assembling a test cartridge, which is based on the above-mentioned POCT microfluidic test cartridge automatic assembly production line and includes the following steps:

[0031] S1. Provide a warehouse body and place it in a carrier on the circulating conveyor line in an upside-down state;

[0032] S2. Provide a base and assemble the base onto the compartment body in the vehicle;

[0033] S3, carrying the assembly of the base and the chamber body to the first bonding mechanism, and bonding the base and the chamber body together through the first bonding mechanism to form a first assembly;

[0034] S4. Place the first assembly back into the carrier and place it upside down;

[0035] S5. The circulating conveyor drives the carrier to move the first assembly to the base film thermal bonding unit; a PP film is provided, the PP film is adhered to the designated position on the base, and heat-sealed to achieve sealing and fixation;

[0036] S6. The circulating conveyor line drives the carrier to move the first assembly to the valve body assembly station; the valve body assembly is installed on the base to obtain the second assembly, and then the second assembly is returned to the carrier and placed in the front;

[0037] S7. The circulating conveyor drives the carrier with the second assembly to the film-sticking unit of the warehouse body; a pressure-sensitive membrane and a first waterproof breathable membrane are provided, and the pressure-sensitive membrane and the first waterproof breathable membrane are attached to the designated position on the warehouse body;

[0038] S8. The circulating conveyor line drives the carrier to move the second assembly to the microsphere pre-embedded and card box top cover bonding unit; provides the microspheres and places the microspheres into the designated compartment of the warehouse body;

[0039] S9, the circulating conveyor line drives the carrier to move the second assembly to the next station, provides the top cover, moves the top cover to the carrier and assembles it on the top of the warehouse body;

[0040] S10, carrying the top cover and the second assembly to the second bonding mechanism, bonding the top cover to the top of the chamber body through the second bonding mechanism to obtain a third assembly; then placing the third assembly back into the carrier and placing it face up;

[0041] S11. The circulating conveyor drives the carrier with the third assembly to move to the next station to perform an airtight test on the bonding seal between the silo body and the top cover;

[0042] S12, the circulating conveyor line drives the carrier with the third assembly to move to the reagent pre-embedding unit, and pre-embeds the liquid reagent into the set compartment of the warehouse through the reagent pre-embedding unit;

[0043] S13. The circulating conveyor line drives the carrier carrying the third assembly to the top cover film laminating unit, provides a second waterproof breathable membrane, and affixes the second waterproof breathable membrane to the first top cover body of the top cover through the top cover film laminating unit, thereby sealing each compartment of the warehouse body.

[0044] S14, the circulating conveyor line drives the carrier to move the third assembly to the filter element assembly unit, provides the filter element, and inserts the filter element into the designated hole of the top cover through the filter element assembly unit;

[0045] S15. The circulating conveyor line drives the carrier to move the third assembly to the cover closing and unloading unit. During the movement, the top cover is guided to the cover closing state by the cover closing guide member, and the top cover is completely buckled by the cover pressing mechanism to obtain the test box, and then the test box is taken out from the carrier to realize unloading.

[0046] The present invention discloses an automatic assembly production line and production process method for a POCT microfluidic detection cartridge. By setting a circulating conveyor line in conjunction with a carrier structure, automatic transfer and structural positioning are provided for the assembly of the detection cartridge. A base and chamber bonding unit, a base film thermal bonding unit, a valve body assembly station, a chamber film bonding unit, a microsphere pre-embedding and cartridge top cover bonding unit, a reagent pre-embedding unit, a top cover film bonding unit, a filter element assembly unit, and a cover closing and unloading unit are sequentially arranged along the circulating conveyor line. Automatic feeding of the base, chamber, and top cover, automatic bonding and assembly of the base and chamber, automatic pasting of the PP film on the base, automatic pasting of the first waterproof and breathable film on the chamber and the pressure-sensitive film, automatic placement of microspheres in the chamber, and automatic filling of liquid reagents are achieved. A series of automated operations, including pre-embedding, automatic feeding of the top cover, automatic bonding and assembly of the top cover and the bin body, automatic pasting of the second waterproof and breathable membrane on the top cover and the label on the outer surface of the bin body, automatic assembly of the filter element in the top cover and automatic closing of the top cover, have realized the automatic production of the test box and greatly improved production efficiency. Moreover, this production line can flexibly configure its functions according to the specific structure of the product. For example, if the film material pasting position changes, the number of microspheres or the placement position of the chamber changes, the number of film material pasted changes, the type of pre-embedded reagents or the number and dosage of reagent pre-embedded areas changes, this production line can realize automatic adjustment, and it only needs to adjust the control program. It has high overall flexibility and versatility, and realizes intelligent and flexible production.

[0047] Compared with the prior art, the present invention has the following advantages:

[0048] (1) The production line adopts a circulating conveyor line with a multi-station functional unit to achieve the fully automatic assembly of the test box from the base, the chamber to the top cover, which significantly improves the production efficiency;

[0049] (2) The production line uses visual cameras and high-precision manipulators to achieve precise positioning and manipulation of materials, ensuring consistency in product quality;

[0050] (3) The production line can flexibly adjust functional modules according to the specific structure of the product, adapt to various production needs, and has high versatility and flexible production capacity;

[0051] (4) The production line can adapt to the production needs of different products by adjusting the control program, which reduces the cost of equipment modification and improves the level of intelligence.

[0052] In summary, the present invention provides an efficient, intelligent, and flexible POCT microfluidic detection cartridge automatic assembly production line and production process method, which solves the problem of low production efficiency in the prior art and has significant technological progress and application value. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] Figure 1 Schematic diagram of the structure of the detection box in an embodiment of the present invention;

[0054] Figure 2 Schematic diagram of a top view of the structure of an embodiment of the present invention;

[0055] Figure 3 A schematic structural diagram of a carrier according to an embodiment of the present invention;

[0056] Figure 4 Schematic diagram of the top view of the base chamber bonding unit in an embodiment of the present invention;

[0057] Figure 5 2 is a schematic structural diagram of the movable end of the first handling robot in an embodiment of the present invention;

[0058] Figure 6 Schematic diagram of the structure of the first turntable in an embodiment of the present invention;

[0059] Figure 7 This is a schematic top view of the structure of the base film thermal bonding unit and the valve body assembly station in an embodiment of the present invention;

[0060] Figure 8 Schematic diagram of the three-dimensional structure of the base film thermal bonding unit in an embodiment of the present invention;

[0061] Figure 9 Schematic diagram of the three-dimensional structure of the film-applying unit of the bin body in an embodiment of the present invention;

[0062] Figure 10 Schematic diagram of the top view of the bonding unit between the microsphere pre-embedded and the card box top cover in an embodiment of the present invention;

[0063] Figure 11 Schematic diagram of the structure of the microsphere feeding mechanism and the microsphere transport mechanism in an embodiment of the present invention;

[0064] Figure 12 2 is a schematic structural diagram of the movable end of the second handling robot in an embodiment of the present invention;

[0065] Figure 13 Schematic diagram of the three-dimensional structure of the airtightness detection mechanism in an embodiment of the present invention;

[0066] Figure 14 Schematic diagram of the top view of the reagent pre-embedded unit and the top cover film sticking unit in an embodiment of the present invention;

[0067] Figure 15 Schematic diagram of the three-dimensional structure of the reagent pre-embedded unit in an embodiment of the present invention;

[0068] Figure 16 Schematic diagram of the three-dimensional structure of the top cover film unit in an embodiment of the present invention;

[0069] Figure 17 Schematic diagram of the structure of the first film-sticking assembly and the second film-sticking assembly in an embodiment of the present invention;

[0070] Figure 18 Schematic diagram of the top view of the filter element assembly unit and the box cover blanking unit in an embodiment of the present invention;

[0071] Figure 19 Schematic diagram of the three-dimensional structure of the filter element assembly unit in an embodiment of the present invention;

[0072] Figure 20 Schematic diagram of the structure of the covering guide and the cover pressing mechanism in an embodiment of the present invention;

[0073] Figure 21 Schematic diagram of the structure of the third transport mechanism and the unloading conveyor line in an embodiment of the present invention;

[0074] The numbers in the figure represent:

[0075] 100-POCT microfluidic test cartridge automatic assembly production line;

[0076] 200-test box, 201-base, 202-storage body, 203-top cover, 2031-first top cover body, 2032-second top cover body, 204-valve body assembly;

[0077] 1-Circular conveyor line;

[0078] 2-carrier, 21-first carrying slot, 22-second carrying slot;

[0079] 3-base and chamber bonding unit, 31-chassis feeding mechanism, 32-base feeding mechanism, 33-first handling robot, 331-first gripper assembly, 332-first adsorption plate, 34-first camera, 35-first turntable, 351-jig, 3511-bottom plate, 3512-carrying plate, 3513-connecting rod, 352-bottom support assembly, 3521-first cylinder, 3522-support pad, 353-angle positioning assembly, 3531-second cylinder, 3532-anti-rotation lock block, 354-anti-rotation slot, 36-first bonding mechanism, 37-first handling mechanism, 38-second camera;

[0080] 4-base film laminating and thermal bonding unit, 41-first film material supply mechanism, 42-first film laminating mechanism, 421-first YZ transfer module, 422-second adsorption plate, 43-third camera, 44-thermal bonding mechanism, 441-third cylinder, 442-hot pressing plate;

[0081] 5-valve body assembly station;

[0082] 6 - chamber film laminating unit, 61 - second film material supply mechanism, 62 - third film material supply mechanism, 63 - second film laminating mechanism, 631 - first XYZ transfer module, 632 - first support plate, 633 - first driving member, 634 - first rotating plate, 635 - third adsorption plate, 64 - fourth camera;

[0083] 7-Microsphere pre-embedded and card box top cover bonding unit, 71-Microsphere feeding mechanism, 72-Microsphere transporting mechanism, 721-Second YZ transfer module, 722-Fourth adsorption plate, 73-Second turntable, 74-Second bonding mechanism, 75-Second transporting mechanism, 76-Top cover feeding mechanism, 77-Second transport robot, 771-Second clamping jaw assembly, 772-Third clamping jaw assembly, 78-Airtight detection mechanism, 781-Jumping module, 782-Airtight plate, 783-Fourth cylinder;

[0084] 8-reagent pre-embedded unit, 81-second driving member, 82-second support plate, 83-filling needle, 84-liquid feeding module, 85-pump module;

[0085] 9 - top cover film laminating unit, 91 - fourth film material supply mechanism, 92 - fifth film material supply mechanism, 93 - third film laminating mechanism, 931 - second XYZ transfer module, 932 - third support plate, 933 - first film laminating assembly, 9331 - third driving member, 9332 - second rotating plate, 9333 - fifth adsorption plate, 934 - second film laminating assembly, 9341 - fifth cylinder, 9342 - fourth support plate, 9343 - sixth cylinder, 9344 - sixth adsorption plate, 94 - sixth camera, 95 - seventh camera;

[0086] 10-filter element assembly unit, 101-filter element feeding mechanism, 1011-first feeding tray, 1012-second feeding tray, 1013-synchronous belt, 102-filter element transport mechanism, 1021-third XYZ transfer module, 1022-suction nozzle;

[0087] 30-covering and unloading unit, 301-covering guide, 3011-flat plate limiting part, 30111-avoidance perforation, 3012-guide rib, 302-covering mechanism, 3021-seventh cylinder, 3022-covering rod, 303-unloading conveyor line, 304-third transport mechanism, 3041-fourth XYZ transfer module, 3042-fourth clamping jaw assembly. DETAILED DESCRIPTION

[0088] Example 1:

[0089] Please refer to Figures 1-21 This embodiment is an automated assembly line 100 for POCT microfluidic test cartridges. It includes a circulating conveyor line 1 that transports materials along the X-direction, a carrier 2 that circulates along this line, a base and chamber bonding unit 3, a base film thermal bonding unit 4, a valve assembly station 5, a chamber film bonding unit 6, a microsphere pre-embedding and cartridge top cover bonding unit 7, a reagent pre-embedding unit 8, a top cover film bonding unit 9, a filter element assembly unit 10, and a cover closing and unloading unit 30. These functional units work together to complete the assembly process of the test cartridge 200.

[0090] In this embodiment, an automatic assembly production line 100 for a POCT microfluidic test cartridge is used to produce a test cartridge 200. The test cartridge 200 includes a base 201, a housing 202 located on the base 201, a top cover 203 disposed on the housing 202, and a valve assembly 204 assembled at the bottom of the base 201. A PP film is adhered to a designated position on the lower surface of the base 201, a pressure-sensitive membrane and a first waterproof and breathable membrane are adhered to designated positions on the housing 202, freeze-dried pellets are contained in some compartments of the housing 202, and liquid medicine is filled in some other compartments. The top cover 203 includes a first top cover body 2031 and a second top cover body 2032. The first top cover body 2031 is fixed to the top of the housing 202, and the second top cover body 2032 can be opened and closed to cover the first top cover body 2031. A second waterproof and breathable membrane is adhered to a designated position on the first top cover body 2031, and a filter element is placed in a designated hole.

[0091] The circulating conveying line 1 includes an upper conveying line (not marked in the figure) and a lower conveying line (not marked in the figure) distributed up and down, and a lifting conveying line (not marked in the figure) arranged at both ends to connect the upper conveying line and the lower conveying line, thereby realizing the circulating conveying of materials at different heights.

[0092] The carrier 2 is provided with a first loading groove 21 and a second loading groove 22. The first loading groove 21 is used to carry the inverted hopper body 202. The hopper body 202 and the base 201 are assembled and the PP film is attached to the base 201 in the first loading groove 21. After the hopper body 202 and the base 201 are bonded together, before the valve body assembly 204 is assembled, the bonded assembly of the hopper body 202 and the base 201 is placed upside down in the first loading groove 21. The second loading groove 22 is used to carry the bonded assembly of the hopper body 202 and the base 201 in an upright position for subsequent operations such as film application, filling, microsphere placement, and filter element placement.

[0093] The base-bin bonding unit 3 includes a bin feeding mechanism 31 and a base feeding mechanism 32, a first transport robot 33 for transporting the bin 202 and the base 201, a first camera 34 and a first turntable 35 located within the working range of the first transport robot 33, a first bonding mechanism 36 and a first transport mechanism 37 arranged around the first turntable 35, and a second camera 38 arranged within the working range of the first transport mechanism 37.

[0094] The warehouse body feeding mechanism 31 and the base feeding mechanism 32 supply the warehouse body 202 and the base 201 respectively; the first handling robot 33 picks up the warehouse body 202 from the warehouse body feeding mechanism 31 and places it in the first carrying slot 21 of the carrier 2, then picks up the base 201 from the base feeding mechanism 32 and takes a picture above the first camera 34, and then accurately places it on the warehouse body 202 in the carrier 2, so as to assemble the warehouse body 202 and the base 201, and then takes the warehouse body 202 and the base 201 out of the carrier 2 together and places them on the first turntable 35; the first turntable 35 carries the warehouse body 202 and The base 201 rotates to the first bonding mechanism 36, which uses ultrasonic welding technology to bond the chamber 202 and the base 201 together to form a first assembly. The first turntable 35 carries the assembly and rotates it to the first transport mechanism 37. The first transport mechanism 37 removes the first assembly from the first turntable 35 and moves it above the second camera 38 to take a picture and check whether the bonding is qualified. The first assembly is then placed back into the first loading slot 21 of the carrier 2 in an upside-down position, completing the assembly and loading of the chamber 202 and the base 201. The first assembly is placed upside-down in the first loading slot 21, with the lower surface of the base 201 facing upward, so that the PP film can be attached to the lower surface of the base 201.

[0095] In this embodiment, the bin feeding mechanism 31 and the base feeding mechanism 32 are arranged side by side and use a tray to feed the material, and the feeding end extends into the working range of the first handling robot 37. In other embodiments, the bin feeding mechanism 31 and the base feeding mechanism 32 can also use other feeding methods, such as a vibrating tray.

[0096] The movable end of the first handling robot 33 is provided with a first clamping claw assembly 331 for clamping the warehouse body 202 , the first assembly, and a first adsorption plate 332 of the adsorption base 201 .

[0097] Several jigs 351 are set at equal angles on the first turntable 35. The jigs 351 are set on the first turntable 35 so as to move up and down as a whole and include a base plate 3511 located below the first turntable 35, a carrier plate 3512 located above the first turntable 35, and a connecting rod 3513 connecting the base plate 3511 and the carrier plate 3512 and passing through the first turntable 35.

[0098] A bottom support assembly 352 is provided below the first turntable 35, corresponding to the working position of the first bonding mechanism 36, to lift the jig 351 upward and provide bottom support for the jig 351. The bottom support assembly 352 includes a first cylinder 3521 and a support pad 3522, which is driven by the first cylinder 3521 to move horizontally to the bottom of the jig 351 and lift the jig 351 upward. When the hopper body 202 is bonded to the base 201, the support pad 3522 extends, and the jig 351 as a whole sits on the support pad 3522, providing bottom support for the jig 351. This not only ensures the stable position of the material in the jig 351, but also prevents excessive bonding pressure from damaging the first turntable 355.

[0099] To further ensure the stability of the material's position during the bonding process, an angle positioning assembly 353 is installed next to the first turntable 35. This assembly includes a second cylinder 3531 and a locking block 3532, which is driven horizontally by the second cylinder 3531. A locking groove 354 is provided on the circumference of the first turntable 35, which engages with the locking block 3532. When the first turntable 35 rotates to a set angle and needs to stop, the locking block 3532 extends into the locking groove 354, effectively positioning the first turntable 35, preventing it from shaking and ensuring the precise and stable positioning of the material.

[0100] The base film laminating and thermal bonding unit 4 includes a first film material supply mechanism 41, a first film laminating mechanism 42 that suction-bonds the PP film discharged by the first film material supply mechanism 41 to a designated location on the lower surface of the base 201, a third camera 43 positioned within the operating range of the first film laminating mechanism 42, and a thermal bonding mechanism 44 positioned above the circulating conveyor line 1 and heat-sealing the PP film to the base 201. The first film material supply mechanism 41 automatically supplies the PP film. The first film material supply mechanism 41 suctions the PP film above the third camera 43 to capture its position on the first film material supply mechanism 41. The film is then precisely affixed to a designated location on the assembly within the carrier 2. The thermal bonding mechanism 44 then heat-compresses and seals the PP film, completing the PP film laminating operation.

[0101] The first film material supply mechanism 41 adopts a feeder mechanism in the prior art to realize automatic feeding of PP film.

[0102] The first film attaching mechanism 42 includes a first YZ transfer module 421 and a second adsorption plate 422 provided at a movable end of the first YZ transfer module 421. The second adsorption plate 422 is used to adsorb the PP film.

[0103] The thermal bonding mechanism 44 includes a third cylinder 441 and a hot pressing plate 442 driven by the third cylinder 441 to move up and down.

[0104] Valve body assembly station 5 is primarily a manual operation station. The operator installs the valve body assembly 204 onto the lower surface of the base 201 to obtain a second assembly. The second assembly is then placed face-up into the second loading slot 22 of the carrier 2. The second assembly is placed in the second loading slot 22 with the top of the chamber 202 facing upward, facilitating subsequent operations such as pre-embedding liquid reagents, placing freeze-dried pellets, applying film, and assembling the top cover 203.

[0105] The warehouse film pasting unit 6 includes a second film material supply mechanism 61 and a third film material supply mechanism 62, a second film pasting mechanism 63 that absorbs the film material at the output ends of the second film material supply mechanism 61 and the third film material supply mechanism 62 and pastes it to the specified position of the warehouse body 202, and a fourth camera 64 arranged in the working range of the second film pasting mechanism 63.

[0106] The second film material supply mechanism 61 and the third film material supply mechanism 62 are arranged side by side to supply the pressure sensitive film and the first waterproof breathable film respectively. The second film material supply mechanism 61 and the third film material supply mechanism 62 adopt the feeder mechanism in the prior art.

[0107] The second film-applying mechanism 63 comprises a first XYZ transfer module 631, a first support plate 632 disposed at the movable end of the first XYZ transfer module 631, a first driver 633 fixed to the first support plate 632, a first rotating plate 634 driven by the first driver 633 to rotate about the Z-axis, and a third suction plate 635 elastically floatingly disposed on the first rotating plate 634. The operating range of the first XYZ transfer module 631 covers the second film supply mechanism 61, the third film supply mechanism 62, the fourth camera 64, and the carrier 2 moved to the film-applying unit 6 of the chamber body. This allows the third suction plate 635 to absorb the corresponding film from the second and third film supply mechanisms 61, 62, and apply it to the material in the carrier 2. The first driver 633, in conjunction with the fourth camera 64, allows the angle of the film on the third suction plate 635 to be adjusted, ensuring precise application of the film to the desired location, improving film application accuracy and ensuring the sealing of the flow channel within the detection box 200.

[0108] In other embodiments, the bin film pasting unit 6 may also be configured with two film material supply mechanisms, two film pasting mechanisms, and two visual cameras to respectively complete the feeding, adsorption and conveying, and pasting operations of the pressure-sensitive film and the first waterproof and breathable film.

[0109] The microsphere pre-embedding and card box top cover bonding unit 7 includes a microsphere placing station, a top cover assembly station and a top cover bonding station arranged along the circulating conveyor line 1; the microsphere placing station is provided with a microsphere feeding mechanism 71 and a microsphere transporting mechanism 72 that absorbs microspheres from the microsphere feeding mechanism 71 and places them into the warehouse body 202; the top cover bonding station is provided with a second turntable 73, a second bonding mechanism 74 and a second transporting mechanism 75, the second bonding mechanism 74 is provided next to the second turntable 73, and the second transporting mechanism 75 is used to transport the bonded material on the second turntable 73 to the carrier 2 on the circulating conveyor line 1; the top cover assembly station is provided with a top cover feeding mechanism 76 and a second transporting robot 77; the second transporting robot 77 transports the top cover 203 on the top cover feeding mechanism 76 to the carrier 2 and assembles it with the warehouse body 202, and then transports the top cover 203 and the warehouse body 202 together to the second turntable 73.

[0110] The microsphere feeding mechanism 71 delivers one lyophilized microsphere at a time to a preset location. It then draws up the lyophilized microspheres at the preset location and transports them above the carrier 2, where they are placed into a designated chamber within the chamber 202. The microsphere feeding mechanism 71 can utilize conventional air blowing to achieve feeding. The microsphere transport mechanism 72 includes a second YZ transfer module 721 and a fourth adsorption plate 722 disposed at the movable end of the second YZ transfer module 721.

[0111] The top cover feeding mechanism 76 supplies the top cover 203 in a tray feeding manner, and the top cover 203 is in an open state when it is fed.

[0112] The movable end of the second handling robot 77 is provided with a second clamping claw assembly 771 for clamping the top cover 203 and a third clamping claw assembly 772 for clamping the top cover 203 and the second assembly. The second clamping claw assembly 771 specifically clamps the first top cover body 2031 of the top cover 203.

[0113] A fifth camera (not shown) is provided within the working range of the second handling robot 77 to locate the position of the top cover 203 on the second clamping jaw assembly 771 to ensure that the top cover 203 can be accurately assembled with the top of the warehouse body 202 in the second assembly.

[0114] The second turntable 73 is used to receive the assembly of the top cover 203 and the second assembly on the second handling robot 77, and then rotate to the second bonding mechanism 74, and bond the top cover 203 and the warehouse body 202 in the second assembly together through the second bonding mechanism 74 to form a third assembly; the second turntable 73 rotates with the third assembly to the unloading position, and the second handling mechanism 75 takes the third assembly out of the second turntable 73 at the unloading position and places it on the carrier 2 on the circulating conveyor line 1.

[0115] The microsphere pre-embedding and cartridge top cover bonding unit 7 also includes an airtightness detection mechanism 78, located downstream of the top cover bonding station, for detecting whether the top cover 203 and the chamber body 202 are bonded properly. The airtightness detection mechanism 78 is located above the circulating conveyor line 1 and includes a lifting module 781 that lifts the carrier 2 upward from the circulating conveyor line 1, an airtight plate 782 located directly above the lifting module 781, a fourth cylinder 783 that drives the airtight plate 782 up and down, and an airtightness detection system (not shown) in air communication with the airtight plate 782.

[0116] The reagent pre-embedded unit 8 includes a second driving member 81, a second support plate 82 driven by the second driving member 81 to move up and down, a plurality of filling needles 83 arranged on the second support plate 82, a liquid medicine supply module 84 connected to the filling needles 83 through pipelines, and a pump module 85 that quantitatively pumps the liquid medicine from the liquid medicine supply module 84 to the end of the filling needles 83.

[0117] The top cover film-applying unit 9 is primarily used to apply a second waterproof, breathable film to a designated location on the first top cover body 2031. Depending on product requirements, a label may also need to be applied to the outer surface of the chamber body 202. To achieve this function, this embodiment integrates label application on the chamber body 202 into the top cover film-applying unit 9. Therefore, in this embodiment, the top cover film-applying unit 9 includes a fourth film material supply mechanism 91 and a fifth film material supply mechanism 92; a third film-applying mechanism 93, which absorbs film material at the output ends of the fourth and fifth film material supply mechanisms 91 and 92 and applies it to a designated location; and a sixth camera 94, which is positioned within the operating range of the third film-applying mechanism 93.

[0118] The fourth film material supply mechanism 91 and the fifth film material supply mechanism 92 are arranged side by side to supply the second waterproof breathable film and the bin body label respectively. The fourth film material supply mechanism 91 and the fifth film material supply mechanism 92 adopt the feeder mechanism in the prior art.

[0119] The third film-applying mechanism 93 includes a second XYZ transfer module 931, a third support plate 932 mounted at the movable end of the second XYZ transfer module 931, and a first film-applying assembly 933 and a second film-applying assembly 934 secured to the third support plate 932. The first film-applying assembly 933 is used to apply the second waterproof and breathable film, while the second film-applying assembly 934 is used to apply the label to the container. The first film-applying assembly 933 includes a third driving member 9331 secured to the third support plate 932, a second rotating plate 9332 driven by the third driving member 9331 to rotate about the Z-axis, and a fifth suction plate 9333 elastically mounted on the second rotating plate 9332 to float vertically. The second film-applying assembly 934 includes a fifth cylinder 9341 secured to the third support plate 932, a fourth support plate 9342 driven up and down by the fifth cylinder 9341, a sixth cylinder 9343 secured to the fourth support plate 9342, and a sixth suction plate 9344 driven by the sixth cylinder 9343 to rotate about the X-axis. Driven by the sixth cylinder 9343, the sixth adsorption plate 9344 switches between vertical and horizontal states. In the vertical state, it adsorbs the warehouse label from the fifth film material supply mechanism 92, and in the horizontal state, it sticks the warehouse label to the outer surface of the warehouse body 202.

[0120] After absorbing the second waterproof and breathable film and the warehouse label, the third film-sticking mechanism 93 moves to the top of the sixth camera 94 for positioning, and then sticks them to the designated position accurately.

[0121] A seventh camera 95 is provided above the circulating conveyor line 1 and downstream of the third film-sticking mechanism 93 to detect whether the second waterproof and breathable film on the top cover 203 is correctly pasted, thereby ensuring the quality of the product flowing to the next workstation.

[0122] The filter element assembly unit 10 is mainly used to assemble the filter element into the designated hole on the top cover 203, and includes a filter element feeding mechanism 101 and a filter element transporting mechanism 102 that absorbs the filter element from the filter element feeding mechanism 101 and places it into the product designated hole on the carrier 2.

[0123] The filter element feeding mechanism 101 utilizes a tray feed mechanism, comprising a first feed tray 1011 and a second feed tray 1012, arranged in layers above and below, and a fourth drive member (not shown) that drives the first and second feed trays 1011, 1012 to alternately move between the feeding and replenishment positions. The first and second feed trays 1011, 1012 are staggered in height to ensure their horizontal movement does not interfere with each other. The fourth driving member drives the synchronous belt 1013 for circular conveying. The first feeding tray 1011 is fixedly connected to the upper belt body of the synchronous belt 1013, and the second feeding tray 1012 is fixedly connected to the lower belt body of the synchronous belt 1013. Therefore, when the fourth driving member 1 drives the synchronous belt 1013 for circular transmission, the first feeding tray 1011 and the second feeding tray 1012 move horizontally in opposite directions, and can alternately appear at the feeding position and the replenishment position. At the feeding position, the fully loaded tray is fed. At the replenishment position, the operator takes out the empty tray and then puts the fully loaded tray to realize material replenishment. The two trays feed alternately to realize continuous feeding of materials.

[0124] The filter element transport mechanism 102 includes a third XYZ transfer module 1021 and a suction nozzle 1022 disposed at a movable end of the third XYZ transfer module 1021 .

[0125] The capping and unloading unit 30 is mainly used to cap the second top cover body 2032 of the top cover 203 on the first top cover body 2031 to obtain the test box 200, and then remove the test box 200 from the carrier 2 for unloading. The capping and unloading unit 30 includes a capping station, a capping guide 301 that guides and constrains the second top cover body 2032 to the capping state as the carrier 2 moves from the filter element assembly unit 10 to the capping station, a capping mechanism 302 arranged above the capping station, an unloading conveyor line 303 located next to the capping station, and a third conveying mechanism 304 that removes the test box 200 from the carrier 2 at the capping station and places it on the unloading conveyor line 303.

[0126] In this embodiment, the capping guide 301 is a rib structure with a head end A and a tail end B. The head end A extends to the filter element assembly station, while the tail end B extends to the capping station. A flat plate stopper 3011 is provided at the tail end B. At the filter element assembly station, the second top cover body 2032 is in the open position. The head end A is located at the rear of the chamber 202, and the flat plate stopper 3011 is located above the top cover 203. During the process of the carrier 2 moving from the filter element assembly station to the capping station, the guide rib 3012 between the head end A and the tail end B gradually constrains the second top cover body 2032 from the open state to the closed state, and at the capping station, the flat plate limiting portion 3011 is arranged above the top cover 203 to limit the second top cover body 2032 to the closed state, but the second top cover body 2032 and the first top cover body 2031 may not be fully engaged. Therefore, the second top cover body 2032 is pressed down by the capping mechanism 302 to fully engage the second top cover body 2032 with the first top cover body 2031 to realize the top cover closing operation.

[0127] The cover pressing mechanism 302 includes a seventh cylinder 3021 and a cover pressing rod 3022 driven by the seventh cylinder 3021 to move up and down. The flat plate limiting portion 3011 is provided with an avoidance through-hole 30111 for the cover pressing rod 3022 to pass through, so that the cover pressing rod 3022 can pass through the flat plate limiting portion 3011 and directly apply downward pressure on the second top cover body 2032.

[0128] In this embodiment, the test box 200 is received by a conveyor line, which can then be directly connected to a packaging line for packaging, or a conveying mechanism can be used to transport multiple test boxes at a time and place them on a support tray for receiving. In other embodiments, a packaging tray can be used directly instead of the unloading conveyor line 303 for receiving.

[0129] The third transport mechanism 304 includes a fourth XYZ transfer module 3041 and a fourth clamping jaw assembly 3042 disposed at a movable end of the fourth XYZ transfer module 3041 .

[0130] In this embodiment, the first bonding mechanism 36 and the second bonding mechanism 74 are both ultrasonic welding mechanisms.

[0131] This embodiment also provides a method for automatically assembling a test cartridge, which is implemented based on the above-mentioned POCT microfluidic test cartridge automatic assembly production line 100 and includes the following steps:

[0132] S1. Provide a silo 202 and place it in an upside-down position on a carrier 2 on a circulating conveyor line 1.

[0133] S2. Provide a base 201 and assemble the base 201 onto the compartment 202 in the carrier 2;

[0134] S3, transporting the assembly of the base 201 and the chamber body 202 to the first bonding mechanism 36, and bonding the base 201 and the chamber body 202 together through the first bonding mechanism 36 to form a first assembly;

[0135] S4, placing the first assembly back into the carrier 2 and placing it in an upside-down position;

[0136] S5. The circulating conveyor line 1 drives the carrier 2 to move the first assembly to the base film thermal bonding unit 4; a PP film is provided, and the PP film is attached to the designated position on the base 201 and heat-sealed to achieve sealing and fixation;

[0137] S6. The circulating conveyor line 1 drives the carrier 2 to move the first assembly to the valve body assembly station 5; the valve body assembly 204 is installed on the base 201 to obtain the second assembly, and then the second assembly is returned to the carrier 2 and placed in the front;

[0138] S7: The circulating conveyor line 1 drives the carrier 2 to move the second assembly to the warehouse film-sticking unit 6; the pressure-sensitive film and the first waterproof breathable film are provided and attached to the designated position on the warehouse body 202;

[0139] S8. The circulating conveyor line 1 drives the carrier 2 with the second assembly to the microsphere pre-embedded and cartridge top cover bonding unit 7; provides microspheres (such as freeze-dried microspheres) and places them into a designated compartment of the bin body 202;

[0140] S9, the circulating conveyor line 1 drives the carrier 2 to move the second assembly to the next station, provides the top cover 203, moves the top cover 203 to the carrier 2 and assembles it on the top of the warehouse body 202;

[0141] S10. Move the top cover 203 and the second assembly to the second bonding mechanism 74. Bond the top cover 203 to the top of the chamber body 202 via the second bonding mechanism 74 to obtain a third assembly. Place the third assembly back into the carrier 2 and position it facing forward.

[0142] S11, the circulating conveyor line 1 drives the carrier 2 to move the third assembly to the next station to perform an airtightness test on the bonding seal between the silo 202 and the top cover 203;

[0143] S12, the circulating conveyor line 1 drives the carrier 2 with the third assembly to move to the reagent pre-embedding unit 8, and pre-embeds the liquid reagent into the set chamber of the warehouse body 202 through the reagent pre-embedding unit 8;

[0144] S13: The circulating conveyor line 1 drives the carrier 2 with the third assembly to the top cover film-sticking unit 9, provides a second waterproof and breathable membrane, and the top cover film-sticking unit 9 sticks the second waterproof and breathable membrane to the first top cover body 2031 of the top cover 203, thereby sealing the various compartments of the chamber body 202 to prevent the drug solution from leaking.

[0145] S14, the circulating conveyor line 1 drives the carrier 2 to move the third assembly to the filter element assembly unit 10, provides the filter element, and inserts the filter element into the designated hole of the top cover 203 through the filter element assembly unit 10;

[0146] S15. The circulating conveyor line 1 drives the carrier 2 to move with the third assembly to the cover closing and unloading unit 30. During the movement, the second top cover body 2032 of the top cover 203 is guided from the open state to the closed state by the cover guide 301, and the second top cover body 2032 is completely fastened on the first top cover body 2031 by the cover pressing mechanism 302 to obtain the detection box 200, and then the detection box 200 is taken out from the carrier 2 to realize unloading; the empty carrier 2 flows back to the base bin bonding unit 3 through the circulating conveyor line 1 to carry out the next cycle of production operation.

[0147] The present embodiment provides a POCT microfluidic detection cartridge automatic assembly production line 100, which can flexibly configure its functions according to the specific structure of the product. For example, changes in the film material pasting position, the number of microspheres or the placement chamber position, the number of film materials pasted, the type of liquid reagent pre-embedded or the number and dosage of reagent pre-embedded areas, etc. can all be automatically adjusted by adjusting the control program. It has high overall flexibility and versatility, and realizes intelligent and flexible production.

[0148] The above are only some embodiments of the present invention. For those skilled in the art, several modifications and improvements can be made without departing from the inventive concept of the present invention, which all fall within the scope of protection of the present invention.

Claims

1. A POCT microfluidic detection cartridge automatic assembly production line, characterized by: It includes a circulating conveyor line and a carrier transported on the circulating conveyor line; along the circulating conveyor line are arranged in sequence: A base-to-bin bonding unit bonds the base and the bin together to form a first assembly, and includes a bin feeding mechanism and a base feeding mechanism, a first handling robot for handling the bin and the base, a first turntable within the working range of the first handling robot, and a first bonding mechanism and a first handling mechanism disposed around the first turntable; A base film laminating and thermal bonding unit, which adheres the first film material to the base and includes a first film material supply mechanism, a first film laminating mechanism, and a thermal bonding mechanism located above the circulating conveyor line; The valve body assembly station manually assembles the valve body assembly onto the first assembly to obtain a second assembly; a bin body film pasting unit for pasting the second film material and / or the third film material on the bin body; A microsphere pre-embedded and cartridge top cover bonding unit is configured to place microspheres in the bin body and bond the top cover to the top of the bin body to obtain a third assembly; the unit includes a microsphere feeding mechanism and a microsphere transport mechanism, a top cover feeding mechanism and a second turntable, a second transport robot for transporting materials between the top cover feeding mechanism, the carrier, and the second turntable, a second bonding mechanism disposed adjacent to the second turntable, and a second transport mechanism for removing the third assembly from the second turntable and placing it in the carrier. A reagent pre-embedding unit for pre-embedding reagents in a set area within the bin; a top cover film pasting unit for pasting a fourth film material on the top cover; A filter element assembly unit, which inserts the filter element into the designated hole of the top cover and includes a filter element feeding mechanism and a filter element transport mechanism; The cover closing and unloading unit converts the top cover in the open state into the closed state to obtain the detection box, and takes the detection box out of the carrier for unloading. The unit includes a cover pressing station, a cover closing guide that guides and constrains the top cover to the closed state when the carrier moves to the cover pressing station, a cover pressing mechanism arranged above the cover pressing station, and a third transport mechanism that takes the detection box out of the carrier at the cover pressing station.

2. The automatic assembly production line for POCT microfluidic detection cartridges according to claim 1, characterized in that: The carrier is provided with a first carrying slot and a second carrying slot, the first handling robot clamps the warehouse body and places it in an upside-down state in the first carrying slot, then clamps the base and assembles it on the warehouse body in the first carrying slot, and then clamps the base and the warehouse body together and places them in the first turntable; the first handling mechanism takes out the first assembly from the first turntable and places it in an upside-down state in the first carrying slot; at the valve body assembly station, the second assembly obtained after the valve body assembly is manually assembled is placed back in the second carrying slot in a front state.

3. The automatic assembly production line for POCT microfluidic detection cartridges according to claim 1, characterized in that: A first camera is set within the working range of the first transport robot, and the first transport robot clamps the base to the top of the first camera for positioning and then assembles it to the warehouse body located in the carrier; a second camera is set within the working range of the first transport mechanism, and the first transport mechanism clamps the first combination formed by bonding the base and the warehouse body to the top of the second camera for bonding quality inspection, and then puts the first combination back into the carrier located on the circulating conveyor line.

4. The automatic assembly line for POCT microfluidic detection cartridges according to claim 1, characterized in that: The movable end of the first handling robot is provided with a first clamping claw assembly for clamping the warehouse body and the first combination and a first adsorption plate for adsorbing the base; a plurality of jigs for carrying the first combination are provided at equal angles on the first turntable.

5. The automatic assembly production line for POCT microfluidic detection cartridges according to claim 1, characterized in that: A third camera is arranged within the working range of the first film-laminating mechanism. The first film-laminating mechanism absorbs the first film material and moves it above the third camera for positioning before pasting it to the designated position of the base. The first film-laminating mechanism includes a first YZ transfer module and a second adsorption plate arranged at the movable end of the first YZ transfer module. The thermal bonding mechanism includes a third cylinder and a hot pressing plate driven by the third cylinder to move up and down.

6. The automatic assembly production line for POCT microfluidic detection cartridges according to claim 1, characterized in that: The warehouse film pasting unit includes a second film material supply mechanism and a third film material supply mechanism, a second film pasting mechanism that absorbs the film material at the output ends of the second film material supply mechanism and the third film material supply mechanism and pastes it to a designated position of the warehouse body, and a fourth camera arranged within the working range of the second film pasting mechanism.

7. The automatic assembly line for POCT microfluidic detection cartridges according to claim 6, characterized in that: The second film-laminating mechanism includes a first XYZ transfer module, a first support plate arranged at the movable end of the first XYZ transfer module, a first driving member fixed on the first support plate, a first rotating plate driven by the first driving member to rotate around the Z axis, and a third adsorption plate elastically floating up and down on the first rotating plate.

8. The automatic assembly production line for POCT microfluidic detection cartridges according to claim 1, characterized in that: The microsphere pre-embedding and card box top cover bonding unit includes a microsphere placing station, a top cover assembly station and a top cover bonding station arranged along the circulating conveying line; the microsphere feeding mechanism and the microsphere transporting mechanism are arranged at the microsphere placing station; the second turntable, the second bonding mechanism and the second transporting mechanism are arranged at the top cover bonding station; the top cover feeding mechanism and the second transport robot are arranged at the top cover assembly station; the movable end of the second transport robot is provided with a second clamping claw assembly for clamping the top cover and a third clamping claw assembly for clamping the top cover and the second combination; a fifth camera is provided within the working range of the second transport robot, and after the second transport robot clamps the top cover, it moves to the top of the fifth camera for positioning and then assembles it to the top of the warehouse body in the second combination.

9. The automatic assembly production line for POCT microfluidic detection cartridges according to claim 8, characterized in that: The microsphere pre-embedded and card box top cover bonding unit also includes an airtight detection mechanism, which is arranged above the circulating conveyor line and downstream of the top cover bonding station; the airtight detection mechanism includes a lifting module that lifts the carrier upward from the circulating conveyor line, an airtight plate located directly above the lifting module, a fourth cylinder that drives the airtight plate to move up and down, and an airtight detection system connected to the air path of the airtight plate.

10. The automatic assembly production line for POCT microfluidic detection cartridges according to claim 1, characterized in that: The top cover film pasting unit includes a fourth film material supply mechanism, a third film pasting mechanism that absorbs the film material at the output end of the fourth film material supply mechanism and pastes it to a designated position on the top cover, and a sixth camera arranged within the working range of the third film pasting mechanism; The third film pasting mechanism includes a second XYZ transfer module, a third support plate arranged at the movable end of the second XYZ transfer module, and a first film pasting assembly fixed on the third support plate; the first film pasting assembly includes a third driving member fixed on the third support plate, a second rotating plate driven by the third driving member to rotate around the Z axis, and a fifth adsorption plate elastically floating up and down on the second rotating plate.

11. The automatic assembly production line for POCT microfluidic detection cartridges according to claim 10, characterized in that: The top cover film pasting unit also includes a fifth film material supply mechanism arranged side by side with the fourth film material supply mechanism; a second film pasting assembly is also arranged on the third support plate; the second film pasting assembly includes a fifth cylinder fixed on the third support plate, a fourth support plate moved up and down by the fifth cylinder, a sixth cylinder fixed on the fourth support plate, and a sixth adsorption plate driven by the sixth cylinder to flip around the X-axis.

12. The automatic assembly production line for POCT microfluidic detection cartridges according to claim 10, characterized in that: A seventh camera is provided above the circulating conveying line and downstream of the third film pasting mechanism to detect whether the film material position on the top cover is pasted correctly.

13. The automatic assembly production line for POCT microfluidic detection cartridges according to claim 1, characterized in that: The filter element assembly unit includes a filter element feeding mechanism and a filter element transporting mechanism that sucks the filter element from the filter element feeding mechanism and inserts it into the designated hole of the top cover; the filter element transporting mechanism includes a third XYZ transfer module and a suction nozzle arranged at the movable end of the third XYZ transfer module.

14. The automatic assembly production line for POCT microfluidic detection cartridges according to claim 1, wherein: The top cover includes a first top cover body and a second top cover body, the first top cover body is fixed on the top of the warehouse body, and the second top cover body is rotatably connected to the first top cover body; the covering guide is a rib structure and has a head end A and a tail end B, the tail end B extends to the covering station, and a flat plate limiting part is provided at the tail end B; in the initial state, the second top cover body is in an open state; the head end A is located on the rear side of the warehouse body, and the flat plate limiting part is located above the top cover; in the process of the carrier moving to the covering station, the guide ribs between the head end A and the tail end B gradually constrain the second top cover body from the open state to the covering state, and at the covering station, the second top cover body is restricted to the covering state by the flat plate limiting part; the covering mechanism includes a seventh cylinder and a covering rod driven by the seventh cylinder to move up and down, and the flat plate limiting part is provided with an avoidance through-hole for the covering rod to pass through.

15. A method for automatically assembling a test kit, characterized by: The automatic assembly production line of the POCT microfluidic detection cartridge according to claim 1 is implemented and includes the following steps: S1. Provide a warehouse body and place it in a carrier on the circulating conveyor line in an upside-down state; S2. Provide a base and assemble the base onto the compartment body in the vehicle; S3, carrying the assembly of the base and the chamber body to the first bonding mechanism, and bonding the base and the chamber body together through the first bonding mechanism to form a first assembly; S4. Place the first assembly back into the carrier and place it upside down; S5. The circulating conveyor line drives the carrier to move the first assembly to the base film thermal bonding unit; a PP film is provided, the PP film is adhered to the designated position on the base, and heat-sealed to achieve sealing and fixation; S6. The circulating conveyor line drives the carrier to move the first assembly to the valve body assembly station; the valve body assembly is installed on the base to obtain the second assembly, and then the second assembly is returned to the carrier and placed in the front; S7. The circulating conveyor drives the carrier with the second assembly to the film-sticking unit of the warehouse body; a pressure-sensitive membrane and a first waterproof breathable membrane are provided, and the pressure-sensitive membrane and the first waterproof breathable membrane are attached to the designated position on the warehouse body; S8. The circulating conveyor line drives the carrier to move the second assembly to the microsphere pre-embedded and card box top cover bonding unit; provides the microspheres and places the microspheres into the designated compartment of the warehouse body; S9, the circulating conveyor line drives the carrier to move the second assembly to the next station, provides the top cover, moves the top cover to the carrier and assembles it on the top of the warehouse body; S10, carrying the top cover and the second assembly to the second bonding mechanism, bonding the top cover to the top of the chamber body through the second bonding mechanism to obtain a third assembly; then placing the third assembly back into the carrier and placing it face up; S11. The circulating conveyor drives the carrier with the third assembly to move to the next station to perform an airtight test on the bonding seal between the silo body and the top cover; S12, the circulating conveyor line drives the carrier with the third assembly to move to the reagent pre-embedding unit, and pre-embeds the liquid reagent into the set compartment of the warehouse through the reagent pre-embedding unit; S13. The circulating conveyor line drives the carrier carrying the third assembly to the top cover film laminating unit, provides a second waterproof breathable membrane, and affixes the second waterproof breathable membrane to the first top cover body of the top cover through the top cover film laminating unit, thereby sealing each compartment of the warehouse body. S14, the circulating conveyor line drives the carrier to move the third assembly to the filter element assembly unit, provides the filter element, and inserts the filter element into the designated hole of the top cover through the filter element assembly unit; S15. The circulating conveyor line drives the carrier to move the third assembly to the cover closing and unloading unit. During the movement, the top cover is guided to the cover closing state by the cover closing guide member, and the top cover is completely buckled by the cover pressing mechanism to obtain the test box, and then the test box is taken out from the carrier to realize unloading.

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