Mongolian medicine composition for treating stomach treasure daily disease as well as powder and granules of Mongolian medicine composition

Abstract

The invention provides a Mongolian medicine composition for treating stomach treasure daily diseases and powder and granules thereof, and belongs to the technical field of Mongolian medicines. The Mongolian medicine composition provided by the invention consists of the following raw materials: black borneol, calcined gypsum rubrum and bear gall powder in a mass ratio of (10-20): (5-15): 1. By adopting the Mongolian medicine composition with a specific ratio provided by the invention, the optimal effect of treating the stomach treasure daily disease can be realized, and the effect is better than that of a single component. The black borneol, the calcined gypsum rubrum and the bear gall powder have a synergistic effect in the aspect of treating the stomach treasure daily disease, and the treatment advantage is relatively strong. On the basis of the Mongolian medicine theory of conditioning three roots, the stomach function is improved from pathogenesis, and the recurrence rate is remarkably reduced.

Description

Technical Field

[0001] The invention belongs to the technical field of Mongolian medicine, and in particular relates to a Mongolian medicine composition for treating stomach thrush and a powder and granule thereof. Background Art

[0002] Weibaori disease (Weibaori Bing) is a common digestive disease in Mongolian medicine, characterized by symptoms such as epigastric pain, hiccups, acid reflux, nausea, and vomiting. Mucosal bleeding can lead to vomiting blood and melena, resulting in decreased digestive function. Severe cases can result in anemia, weight loss, fatigue, and occult blood in the stool. Patients may experience rhythmic, dull pain in the epigastric region, as well as shooting pain beneath the xiphoid process and in the back, which can be intermittent or continuous. Some patients experience worsening pain after consuming cold foods or exposure to cold in the abdomen; the pain gradually subsides after eating. The pulse is strong and firm, and the tongue coating is thick and yellow. Mongolian medicine considers Weibaori Bing a condition related to gastric dysfunction. A detailed interview with the patient is required to understand their dietary habits, analyze potential predisposing factors such as emotional imbalance and external pathogenic factors, and assess the course of the disease. The patient's condition is analyzed through abdominal palpation, tongue examination, and pulse diagnosis. Treatment is then based on a comprehensive assessment of the patient's constitution and a differentiated diagnosis. It is advisable to regulate the three roots, attack and dispel Baori toxic heat, clear Baori heat evil, and eliminate the heat evil covering the Bada Gan, and treat according to the symptoms. Regional climate factors also play a significant role in the occurrence and development of Baori disease. It is necessary to analyze the regional climate characteristics and physical condition of the patient's residence, clearly distinguish between the heat and cold symptoms of Baori disease, accurately control the cause, and then accurately treat and better control the disease.

[0003] The Mongolian medicine Weibaori disease is similar to Western medicine diseases such as chronic erosive gastritis and gastric ulcer. In recent years, the incidence of chronic erosive gastritis has been on the rise, which is closely related to factors such as the accelerated pace of life of modern people, increased social pressure, and poor eating habits. It is necessary to actively improve its prevention and control level, reduce its incidence, and improve the prognosis of patients. Chronic erosive gastritis has a chronic course, and patients are prone to repeated attacks and the disease is prolonged. Western medicine treatment is mainly based on acid-suppressing drugs, gastric mucosal protective agents and other drugs, but the efficacy is limited, and the recurrence rate of patients is high. It is urgent to optimize the treatment plan. It is particularly important to develop a method based on Mongolian medicine theory to treat Weibaori disease (chronic erosive gastritis). Summary of the Invention

[0004] In view of this, the present invention aims to provide a Mongolian medicine composition for treating Weibaori disease, and its powder and granule formulations. Based on Mongolian medicine theory, the present invention uses black borneol, calcined hanshui stone, and bear bile powder as raw materials to obtain a Mongolian medicine composition that can effectively treat Weibaori disease, thereby solving the problems of limited efficacy and high recurrence rate of Weibaori disease in the prior art.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0006] The invention provides a Mongolian medicine composition for treating stomach thrush. The composition is composed of the following raw materials in a mass ratio: black borneol: calcined hanshui stone: bear bile powder = 10-20:5-15:1.

[0007] Preferably, the composition is composed of the following raw materials in the following mass ratio: black borneol: calcined calcite: bear bile powder = 12-18:8-12:1.

[0008] Preferably, the raw materials are composed of the following mass ratio: black borneol: calcined calcite: bear bile powder = 15:10:1.

[0009] The invention provides a preparation method of the Mongolian medicine composition. Black borneol, calcined calcite and bear bile powder are crushed separately and then mixed to obtain the Mongolian medicine composition.

[0010] Preferably, the crushed particles have a diameter of 150 μm to 180 μm.

[0011] The present invention provides the use of the Mongolian medicine composition or the Mongolian medicine composition obtained according to the preparation method in preparing a medicine for treating gastric thrush.

[0012] Preferably, the dosage form of the drug is powder or granules.

[0013] The present invention also provides a powder for treating stomach ulcer, and the preparation method is as follows:

[0014] (8.1) Grind black borneol, calcined calcite, and bear bile powder separately to obtain fine powders of black borneol, calcined calcite, and bear bile powder;

[0015] (8.2) According to the proportion of the Mongolian medicine composition, mix the black borneol, calcined calcite and bear bile powder to obtain a powder.

[0016] Preferably, the particle size of the powder is 150 μm to 180 μm.

[0017] The present invention also provides a granule for treating gastric dysentery, and the preparation method is as follows:

[0018] (10.1) Grind black borneol, calcined calcite, and bear bile powder separately to obtain fine powders of black borneol, calcined calcite, and bear bile powder;

[0019] (10.2) According to the proportion of the Mongolian medicine composition, black borneol, calcined calcite and bear bile powder are mixed and granulated to obtain granules.

[0020] Compared with the prior art, the present invention has the following beneficial effects: the present invention uses black borneol, calcined hanshui stone, and bear bile powder as main raw materials to successfully develop a Mongolian medicine powder for treating gastric dysmenorrhea. The Mongolian medicine composition with a specific ratio provided by the present invention can achieve the best effect of treating gastric dysmenorrhea, which is better than the effect of the individual components. Black borneol, calcined hanshui stone, and bear bile powder have a synergistic effect in treating gastric dysmenorrhea, with a strong therapeutic advantage. The combination of black borneol and calcined hanshui stone can play a role in eliminating stagnation and relieving stagnation, and regulating cold and heat. It can improve patients' symptoms of mixed cold and heat, insufficient gastric motility, promote gastric function recovery, improve the state of gastric stagnation, and achieve the effect of treating gastric dysmenorrhea. On this basis, combined with the treatment of bear bile powder, it can enhance the choleretic effect, comprehensively regulate Heyi, Xieri and Bada Gan, reduce the irritation of bile reflux on the gastric mucosa, and exert anti-inflammatory and antibacterial effects, promote the repair of gastric mucosal damage, help repair gastric mucosal erosion lesions, and promote patient recovery. The present invention is based on the Mongolian medicine theory of "regulating three roots" to improve gastric function from the cause of the disease and significantly reduce the recurrence rate. DETAILED DESCRIPTION

[0021] The invention provides a Mongolian medicine composition for treating stomach thrush. The composition is composed of the following raw materials in a mass ratio: black borneol: calcined hanshui stone: bear bile powder = 10-20:5-15:1.

[0022] In the present invention, the mass ratio of the black borneol, calcined calcite and bear bile powder is preferably 12-18:8-12:1, and more preferably 15:10:1.

[0023] In the present invention, black borneol is a characteristic medicinal material of Mongolian medicine, which has the effects of digesting food and eliminating accumulation, guiding stagnation and breaking up accumulation, and promoting bile secretion. It is widely used in the treatment of Baori disease, improves the symptoms of epigastric distension and gastrointestinal stagnation, has a reliable therapeutic effect on the indigestion associated with gastric Baori disease, and helps to regulate liver and gallbladder diseases. It has a significant effect on improving the function of the digestive system and is an important drug for the treatment of Baori disease.

[0024] Calcined Hanshui Stone is a commonly used medicine in Mongolian medicine. It has the effect of clearing heat and purging fire. It is mainly used to treat chronic gastritis. It can improve patients' symptoms such as fullness after meals, epigastric pain, and belching. It is an important treatment for gastric disease and can relieve the inflammatory response caused by gastric mucosal lesions. After being processed, calcined Hanshui Stone strengthens its warming and stomach-regulating effects and reduces its coldness. It can play a role in clearing heat and reducing fire, regulating the stomach, promoting the repair of mucosal damage, lowering the pH value in the stomach, and helping to improve the stomach pain and inflammation associated with erosive gastritis.

[0025] Bear bile powder is a commonly used medicine for digestive system diseases. It has the effects of clearing heat, antibacterial and anti-inflammatory, and choleretic and analgesic. It can improve bile reflux symptoms, improve gastric mucosal inflammatory reactions, and help eliminate the cause of chronic gastritis. In addition, the antibacterial and anti-inflammatory effects of bear bile can enhance the anti-inflammatory effects of other ingredients, helping to improve the inflammatory reactions associated with gastric dysentery. The present invention combines black borneol with calcined northern cold water stone to play the role of eliminating stagnation and relieving stagnation, and harmonizing cold and heat. It can improve the patient's symptoms of mixed cold and heat, insufficient gastric motility, promote the recovery of gastric function, improve the state of gastric stagnation, and achieve the effect of treating gastric dysentery. On this basis, combined with bear bile treatment, it can enhance the choleretic effect, comprehensively adjust Heyi, Xieri and Bada Gan, reduce the irritation of bile reflux to the gastric mucosa, and play anti-inflammatory and antibacterial effects, promote the repair of gastric mucosal damage, help repair gastric mucosal erosion lesions, and promote patient recovery. The present invention has no special restrictions on the source of raw materials, and conventional commercially available products can be used.

[0026] The invention provides a preparation method of the Mongolian medicine composition. Black borneol, calcined calcite and bear bile powder are crushed separately and then mixed to obtain the Mongolian medicine composition.

[0027] In the present invention, there is no particular limitation on the pulverization method, and conventional pulverization methods can be used. The particle size of the pulverized particles is 150 μm to 180 μm.

[0028] The present invention provides the use of the Mongolian medicine composition or the Mongolian medicine composition obtained according to the preparation method in preparing a medicine for treating gastric thrush.

[0029] In the present invention, the dosage form of the drug is powder or granules.

[0030] The present invention also provides a powder for treating stomach ulcer, and the preparation method is as follows:

[0031] (8.1) Grind black borneol, calcined calcite, and bear bile powder separately to obtain fine powders of black borneol, calcined calcite, and bear bile powder;

[0032] (8.2) According to the proportion of the Mongolian medicine composition, mix the black borneol, calcined calcite and bear bile powder to obtain a powder.

[0033] In the present invention, the particle size of the powder is 150 μm to 180 μm.

[0034] The present invention also provides a granule for treating gastric dysentery, and the preparation method is as follows:

[0035] (10.1) Grind black borneol, calcined calcite, and bear bile powder separately to obtain fine powders of black borneol, calcined calcite, and bear bile powder;

[0036] (10.2) According to the proportion of the Mongolian medicine composition, black borneol, calcined calcite and bear bile powder are mixed and granulated to obtain granules.

[0037] In the present invention, the particle size of the fine powder is 150 μm to 180 μm.

[0038] The technical solutions provided by the present invention are described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0039] Example 1

[0040] Use a grinder to grind black borneol (purchased from Hebei Jiaheng Lengbei Pharmaceutical Co., Ltd.), calcined hanshui stone (purchased from Anguo Juyaotang Pharmaceutical Co., Ltd.) and bear bile powder (purchased from Dujiangyan Zhongshan Pharmaceutical Factory) separately, pass through a 100-mesh sieve, collect the undersize components, and obtain black borneol fine powder, calcined hanshui stone fine powder and bear bile powder fine powder. Mix the black borneol fine powder, calcined hanshui stone fine powder and bear bile powder fine powder in a mass ratio of 15:10:1 to obtain a powder for treating gastric disease.

[0041] Example 2

[0042] Use a grinder to grind black borneol (purchased from Hebei Jiaheng Lengbei Pharmaceutical Co., Ltd.), calcined hanshui stone (purchased from Anguo Juyaotang Pharmaceutical Co., Ltd.) and bear bile powder (purchased from Dujiangyan Zhongshan Pharmaceutical Factory) separately, pass through a 100-mesh sieve, collect the undersize components, and obtain black borneol fine powder, calcined hanshui stone fine powder and bear bile powder fine powder. Mix the black borneol fine powder, calcined hanshui stone fine powder and bear bile powder fine powder in a mass ratio of 10:5:1 to obtain a powder for treating gastric disease.

[0043] Example 3

[0044] Use a grinder to grind black borneol (purchased from Hebei Jiaheng Lengbei Pharmaceutical Co., Ltd.), calcined hanshui stone (purchased from Anguo Juyaotang Pharmaceutical Co., Ltd.) and bear bile powder (purchased from Dujiangyan Zhongshan Pharmaceutical Factory) separately, pass through a 100-mesh sieve, collect the undersize components, and obtain black borneol fine powder, calcined hanshui stone fine powder and bear bile powder fine powder. Mix the black borneol fine powder, calcined hanshui stone fine powder and bear bile powder fine powder in a mass ratio of 20:15:1 to obtain a powder for treating gastric disease.

[0045] Example 4

[0046] Use a grinder to grind black borneol (purchased from Hebei Jiaheng Lengbei Pharmaceutical Co., Ltd.), calcined hanshui stone (purchased from Anguo Juyaotang Pharmaceutical Co., Ltd.) and bear bile powder (purchased from Dujiangyan Zhongshan Pharmaceutical Factory) separately, pass through a 100-mesh sieve, collect the undersize components, and obtain black borneol fine powder, calcined hanshui stone fine powder and bear bile powder fine powder. Mix the black borneol fine powder, calcined hanshui stone fine powder and bear bile powder in a mass ratio of 15:10:1, and granulate to obtain granules for treating gastric disease.

[0047] Comparative Example 1

[0048] The powder for treating Weibao disease was prepared by the method of embodiment 1, except that the mass ratio was modified from 15:10:1 to 5:2:1.

[0049] Comparative Example 2

[0050] The powder for treating Weibao disease was prepared by the method of embodiment 1, except that the mass ratio was modified from 15:10:1 to 25:20:1.

[0051] Experimental Example 1: Verification of synergistic effect

[0052] GES-1 cells (purchased from Wuhan Punosai Life Science Co., Ltd.) were cultured in high-glucose DMEM (containing 10% bovine serum, 1% penicillin, and 1% streptomycin) in a 37°C 5% CO2 incubator, and cells in the logarithmic growth phase were used for the experiment.

[0053] GES-1 cells in the logarithmic growth phase were cultured at a volume of 100 μL and 2 × 10 6Cells were seeded at a density of 100 cells / mL in a 96-well plate and cultured for 24 h. The cells were divided into a normal group, a model group, an Example 1 group, a comparative example 1 group (D1), a comparative example 2 group (D2), a black borneol group (D3), a calcined nephrite group (D4), a bear bile powder group (D5), a black borneol + calcined nephrite group (D6, black borneol: calcined nephrite = 3:2), a black borneol + bear bile powder group (D7, black borneol: bear bile powder = 15:1), and a calcined nephrite + bear bile powder group (D8, calcined nephrite: bear bile powder = 10:1), with 5 replicate wells in each group. After attachment, the GES-1 cells in the normal group were added to high-glucose DMEM medium, the model group was added to medium containing 0.1% acetic acid, the Example 1 group was added to medium containing 5 μg / mL of the powder obtained in Example 1 and 0.1% acetic acid, D1 was added to medium containing 5 μg / mL of the powder obtained in Comparative Example 1 and 0.1% acetic acid, D2 was added to medium containing 5 μg / mL of the powder obtained in Comparative Example 2 and 0.1% acetic acid, D3 was added to medium containing 5 μg / mL of black borneol powder and 0.1% acetic acid, and D4 was added to medium containing 5 μg / mL calcined halite powder and 0.1% acetic acid were added to the culture medium. D5 was added to the culture medium containing 5 μg / mL bear bile powder and 0.1% acetic acid. D6 was added to the culture medium containing 5 μg / mL black borneol and calcined halite powder and 0.1% acetic acid. D7 was added to the culture medium containing 5 μg / mL black borneol and bear bile powder and 0.1% acetic acid. D8 was added to the culture medium containing 5 μg / mL calcined halite and bear bile powder and 0.1% acetic acid. 100 μL of the culture medium was incubated in a 37°C, 5% CO2 incubator for 4 h. GES-1 cell activity was determined using the MTT assay, and cell survival rate was calculated. The results are shown in Table 1.

[0054] Table 1 Effect of different treatment groups on the survival rate of GES-1 cells

[0055] Group Cell survival rate (%) Group Cell survival rate (%) Normal group 100.00 D4 78.44 Example 1 101.36 D5 79.24 Model Group 17.37 D6 91.89 D1 85.74 D7 90.33 D2 86.79 D8 91.64 D3 79.94

[0056] As shown in Table 1, when GES-1 cells were incubated with 0.1% acetic acid for 4 hours, the cell survival rate was only 17.37%, indicating that a GES-1 cell injury model can be successfully constructed using a 0.1% acetic acid culture medium. Compared with the model group, the use of black borneol, calcined calcite and bear bile powder alone or in pairs can improve the survival rate of GES-1 cells. Comparing the experimental results of the two-by-two ratio with those of Example 1, it can be seen that there is a synergistic effect between the three raw materials, and compared with the comparative example, it can be seen that when the ratio is appropriate, the effect of the two-by-two ratio is better than that of the three-way ratio, indicating that although the three have a synergistic effect, when the ratio changes, it will seriously affect the effect.

[0057] Experimental Example 2

[0058] Case source: 60 patients who visited the outpatient clinic of Erdun Bilige, deputy chief physician, the outpatient clinic of the Department of Gastroenterology, and the ward from May 2024 to May 2025 and met the CEG criteria.

[0059] Identification of CEG patients: Refer to the diagnostic criteria for chronic gastritis in the "Chinese Consensus on Chronic Gastritis" and the "Trial Opinions on Endoscopic Classification and Treatment of Chronic Gastritis" formulated by the Gastroenterology Branch of the Chinese Medical Association in Shanghai in 2017.

[0060] Inclusion criteria: (1) those who met the above CEG Western medicine and Mongolian medicine diagnostic criteria;

[0061] (2) consistent with the endoscopic diagnostic criteria for chronic gastritis with erosion;

[0062] (3) Age: 18 to 75 years old (inclusive), gender is not limited;

[0063] (4) The subjects carefully read and signed the informed consent form for participating in this trial.

[0064] Treatment group (30 cases): The powder obtained in Example 1 was taken orally once a day, 5 g each time, half an hour after a meal, for 1 to 2 months (during this period, if the patient is cured, the drug is no longer taken).

[0065] The control group (30 cases) was treated with esomeprazole magnesium enteric-coated tablets (20 mg * 28 tablets / box, Jiangxi Shanxiang Pharmaceutical (domestic)), 1 tablet each time, once a day, orally half an hour before meals; and aluminum carbonate magnesium chewable tablets (0.5 g * 24 tablets / box, Guangdong China Resources Shunfeng Pharmaceutical Co., Ltd. (domestic)), 2 tablets each time, three times a day, chewed orally 1 to 2 hours after meals; 2 courses of treatment, each course of treatment was 3 weeks, and 1 week of rest was allowed after each course of treatment (during this period, if the patient was cured, he would no longer take the medicine).

[0066] Efficacy evaluation criteria:

[0067] Cure: Disease symptoms and signs are significantly weakened or disappear, and the symptom score is reduced by more than 95%;

[0068] Markedly effective: symptoms and signs improved, with the symptom score reduced by more than 70% but less than 95%;

[0069] Effective: symptoms and signs are alleviated, and the syndrome score decreases by at least 30% but less than 70%;

[0070] Ineffective: Symptoms and signs are not significantly improved, or may even worsen, with the syndrome score decreasing by less than 30%.

[0071] Management of adverse reactions: Safety indicators should be monitored before and after treatment. If a patient experiences any adverse reaction, effective protective measures must be implemented immediately. Cases where the decision to terminate the study should be recorded in detail in the adverse event statistics table and continued follow-up should be conducted.

[0072] The results of different treatment methods are shown in Table 2.

[0073] Cure rate (%) = cure + marked effect + effectiveness / 30 * 100%.

[0074] Table 2 Cure rates of treatment group and control group

[0075] Group Heal (a person) Significantly effective (people) Effective (person) Invalid (person) Cure rate (%) Treatment group 3 19 7 1 96.67％ control group 1 11 16 3 93.33％

[0076] As shown in Table 2, compared with the prior art, the preparation of the present invention is also effective in treating chronic erosive gastritis. Furthermore, because the raw materials used in the preparation of the present invention are all natural medicines, through the compatibility of the drugs and the overall conditioning, it has the advantages of minimal side effects and stable efficacy. Based on the Mongolian medicine theory of "conditioning the three roots," the present invention improves gastric function based on the etiology, significantly reduces recurrence rates, and does not cause drug resistance with long-term use.

[0077] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A Mongolian medicine composition for treating stomach ulcer, characterized in that: The invention is composed of the following raw materials in the following mass ratio: black borneol: calcined calcite: bear bile powder = 10-20:5-15:

1.

2. Mongolian medicine composition according to claim 1, is characterized in that, The invention is composed of the following raw materials in the following mass ratio: black borneol: calcined calcite: bear bile powder = 12-18:8-12:

1.

3. The Mongolian medicine composition according to claim 1 or 2, wherein The product is composed of the following raw materials in the following mass ratio: black borneol: calcined calcite: bear bile powder = 15:10:

1.

4. The method for preparing the Mongolian medicine composition according to any one of claims 1 to 3, characterized in that: Black borneol, calcined hanshui stone and bear bile powder are crushed separately and then mixed to obtain a Mongolian medicine composition.

5. The preparation method according to claim 4, characterized in that The crushed particles have a diameter of 150 μm to 180 μm.

6. Use of the Mongolian medicine composition according to any one of claims 1 to 3 or the Mongolian medicine composition obtained according to the preparation method according to claim 4 or 5 in the preparation of a medicine for treating gastric thrush.

7. The use according to claim 6, characterized in that: The dosage form of the medicine is powder or granule.

8. A powder for treating stomach ulcer, characterized in that: The preparation method is as follows: (8.1) Grind black borneol, calcined calcite, and bear bile powder separately to obtain fine powders of black borneol, calcined calcite, and bear bile powder; (8.2) Mix black borneol, calcined calcite and bear bile powder in the proportions of the Mongolian medicine composition according to any one of claims 1 to 3 to obtain a powder.

9. The powder according to claim 8, characterized in that The particle size of the powder is 150 μm to 180 μm.

10. A granule for treating gastric disease, characterized in that: The preparation method is as follows: (10.1) Grind black borneol, calcined calcite, and bear bile powder separately to obtain fine powders of black borneol, calcined calcite, and bear bile powder; (10.2) According to the proportion of the Mongolian medicine composition described in any one of claims 1 to 3, black borneol, calcined calcite and bear bile powder are mixed and granulated to obtain granules.