Anti-radiation organic salt special for mothers and infants and preparation method thereof

Abstract

The invention discloses special anti-radiation organic salt for mothers and infants and a preparation method of the special anti-radiation organic salt, and belongs to the field of nutritional foods for mothers and infants. The anti-radiation mineral complex is prepared from organic iodine, organic calcium, organic selenium and organic germanium through a solid state fermentation-ultrasonic assembly process, and a Se-Ge-S covalent complex is formed; a nanocarrier; a prebiotic component; and a stabilizer. According to the invention, the bioavailability and absorptivity of mineral substances are remarkably improved: a stable nano-composite is formed through a solid state fermentation-ultrasonic assembly process, and the bioavailability of calcium reaches 43.2 + / -2.0%, which is nearly doubled compared with that of traditional inorganic salts; due to the Se-Ge-S covalent complex, the slow release rate of selenium in simulated gastric juice within 4 hours reaches 82.3 + / -1.5%, and metabolic burden caused by sudden release is avoided; the nano-hydroxyapatite carrier is matched with carboxylated chitosan for modification, so that the intestinal absorption rate of mineral substances is improved.

Description

Technical Field

[0001] The present invention relates to the field of maternal and infant nutritional foods, in particular to radiation-resistant organic maternal and infant special salt and a preparation method thereof. Background Art

[0002] Infants and pregnant women are nutritionally sensitive groups, and their needs for minerals (such as iodine, calcium, selenium, germanium, etc.) are significantly higher than those of ordinary adults. Iodine is a key element for fetal neurodevelopment, and its deficiency can lead to intellectual disability; calcium directly affects the bone growth of infants and young children and the health of pregnant women; selenium and germanium have antioxidant and anti-radiation potential, which can protect developing cells from damage by environmental toxins. However, traditional mineral fortification methods have many problems. Inorganic minerals (such as potassium iodide and calcium carbonate) have low bioavailability (calcium absorption rate <30%) and may irritate the immature digestive system of infants and young children; simple organic forms (such as selenium yeast added alone) are easily inactivated during processing and cannot achieve mineral synergy.

[0003] The currently available salt for mothers and infants generally has limitations. The mineral form is unreasonable. For example, inorganic iodine (such as potassium iodate) is easily volatilized and lost during cooking, and the actual intake is difficult to control; ordinary organic selenium (such as selenomethionine) is easily degraded in the gastric acid environment, and the absorption rate is less than 40%. The formula design is single, only strengthening a single mineral (such as iodized salt or calcium salt), ignoring the comprehensive needs of mothers and infants for multiple minerals; lacking anti-radiation functional ingredients, it cannot cope with the health risks brought by environmental pollution (such as ultraviolet rays, electronic equipment radiation). The process technology is backward, and the physical mixing method leads to uneven distribution of minerals (particle size > 300nm), affecting sensory perception and absorption; high-temperature processing (such as drying > 60°C) destroys heat-sensitive ingredients (such as prebiotics and active peptides).

[0004] Existing anti-radiation foods are mostly targeted at adults (such as nuclear radiation protectants), but there is a gap in the maternal and infant market. They are not safe enough. Adult anti-radiation agents (such as Prussian blue) contain toxic ingredients and are strictly prohibited for use in infants and young children. Their functional forms are inappropriate, and common antioxidants (such as vitamin C) are unable to specifically scavenge free radicals produced by ionizing radiation. Furthermore, they lack a systematic design and fail to consider the specific mineral needs of mothers and infants and their anti-radiation properties.

[0005] Developing an ideal radiation-resistant salt for maternal and infant nutrition requires overcoming three key bottlenecks: efficient mineral utilization, specifically how to improve bioavailability through organic form and processing (e.g., calcium ≥ 40%, selenium ≥ 80%); functional stability, specifically how to ensure that radiation-resistant ingredients (e.g., Se-Ge complexes) do not degrade during storage and digestion; and safety balance, specifically how to enhance functionality while strictly meeting safety standards for infant foods, such as allergens and heavy metals.

[0006] Therefore, those skilled in the art provide radiation-resistant organic maternal and infant-specific salts and preparation methods to solve the problems raised in the above background technology. Summary of the Invention

[0007] The purpose of the present invention is to provide an anti-radiation organic salt specifically for mothers and infants and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0008] To achieve the above object, the present invention provides the following technical solutions:

[0009] Radiation-resistant organic salt for mothers and infants is made from the following raw materials:

[0010] Organic basic salt: ≥97% by weight, selected from organic sun-dried sea salt, rock salt or lake salt;

[0011] Anti-radiation mineral complex: prepared from organic iodine, organic calcium, organic selenium and organic germanium through solid-state fermentation-ultrasonic assembly process to form Se-Ge-S covalent complex, wherein:

[0012] Organic iodine content is 5-10mg / Kg, selected from seaweed iodine or iodized casein;

[0013] Organic calcium content is 5-10mg / Kg, selected from calcium citrate malate or seaweed calcium (calcium bioavailability ≥40%);

[0014] Organic selenium content is 3-8mg / Kg, selected from selenium yeast or selenomethionine;

[0015] The organic germanium content is 2-5 mg / Kg, selected from organic germanium-132 (β-carboxyethyl germanium sesquioxide);

[0016] Organic selenium and organic germanium are transformed into Se-Ge-S covalent complexes through microbial transformation, and their free radical scavenging efficiency is increased by ≥40% compared with that of single components (DPPH method);

[0017] The free radical scavenging rate of Se-Ge-S covalent complex is ≥85% (DPPH method), and the selenium sustained release rate in simulated gastric fluid is 80-90% over 4 hours;

[0018] Nanocarrier: carboxylated chitosan-modified nanohydroxyapatite (average particle size ≤ 50 nm, absolute value of Zeta potential ≥ 35 mV), loaded with radiation-resistant mineral complex, with a binding rate ≥ 90%;

[0019] Prebiotic component: 0.1-0.5% content, selected from oligofructose or human milk oligosaccharide;

[0020] Stabilizer: content 0.05-0.2%, selected from ascorbyl palmitate or natural tocopherol.

[0021] As a further solution: in the radiation-resistant mineral complex, the mass ratio of organic selenium to organic germanium is (1.5-2.0):1, and the total amount of organic iodine, organic calcium, organic selenium, and organic germanium added is ≤0.6%;

[0022] The Se-Ge-S covalent complex was generated by a two-stage solid-state fermentation, with the pH controlled at 4.5±0.2 in the first stage and the redox potential controlled at -150 to -200 mV in the second stage.

[0023] As a further solution: 0.01-0.05% of fucoidan is also included as a radiation protection enhancer, and the mass ratio of fucoidan to Se-Ge-S complex is (0.1-0.3):1. The free radical scavenging rate under synergistic effect is ≥85% (DPPH method).

[0024] As a further solution: the sustained release rate of the anti-radiation mineral complex in a simulated intestinal environment of infants (pH 6.8, 37° C.) is: selenium release ≥ 90% in 24 hours, germanium release ≥ 80% in 24 hours.

[0025] As a further solution: the organic selenium is in the form of selenium yeast with a selenium content of ≥2000 μg / g, and is co-cultured with organic germanium through a solid-state fermentation process, and the redox potential (ORP) is controlled at -150 to -200 mV during the fermentation process.

[0026] The preparation method of the radiation-resistant organic salt for mothers and infants is applied to the above-mentioned radiation-resistant organic salt for mothers and infants, comprising the following steps:

[0027] Step 1: Directed bacterial acclimation: Lactobacillus plantarum is gradually adapted to culture in a medium containing 0.1-0.3 mmol / L sodium selenite to obtain a selenium-resistant strain;

[0028] Step 2: Two-stage solid-state fermentation:

[0029] Stage 1: Mix the activated bacteria with an organic iodine source, an organic calcium source, and selenium yeast and ferment at 37°C for 24 hours;

[0030] Phase II: Add organic germanium source, control pH 4.5±0.2, oxidation-reduction potential (ORP) -150 to -200 mV, and continue fermentation for 48 hours;

[0031] Step 3: Ultrasound-enzyme coupling assembly: The fermentation product was mixed with carboxylated chitosan-modified nanohydroxyapatite and pulse-treated (5s on / 2s off) for 45 minutes under 30kHz / 400W ultrasound and 0.05-0.1% bromelain.

[0032] Step 4: Low-temperature spray drying: inlet air temperature ≤ 45°C, outlet moisture ≤ 5%;

[0033] Step 5: Compound mixing: mixing the dried product with prebiotics, stabilizers and organic basic salts under the protection of inert gas;

[0034] Step 6: Packaging: Use light-proof nitrogen-filled packaging and sterilize with ultraviolet light (5-10mJ / cm 2 ).

[0035] As a further solution: in step three, the mass ratio of nano-hydroxyapatite to radiation-resistant mineral is 1:(0.5-1.0), and the average particle size of the final complex is ≤100 nm (detected by a laser particle size analyzer).

[0036] As a further solution: During the drying process of step 4, the material temperature is monitored in real time to be ≤45°C and the water activity is ≤0.55 to ensure that the retention rate of heat-sensitive components is ≥95%.

[0037] Compared with the prior art, the present invention has the following beneficial effects:

[0038] 1. The present invention significantly improves the bioavailability and absorption rate of minerals: a stable nanocomposite is formed through a solid-state fermentation-ultrasonic assembly process, and the bioavailability of calcium reaches 43.2±2.0%, nearly double that of traditional inorganic salts; the Se-Ge-S covalent complex enables a 4-hour sustained-release rate of selenium in simulated gastric fluid of 82.3±1.5%, avoiding the metabolic burden caused by sudden release; the nanohydroxyapatite carrier is combined with carboxylated chitosan modification to improve the intestinal absorption rate of minerals.

[0039] 2. The present invention has excellent anti-radiation and antioxidant properties: the free radical scavenging rate (DPPH method) reaches 86.7±0.8%, which is significantly higher than that of simple mixed organic salts; under a radiation dose of 2Gy, the cell survival rate is increased to ≥80%; the fucoidan and Se-Ge complex work synergistically, and the selenium retention rate remains at 88.3±0.7% after 6 months of accelerated testing.

[0040] 3. The low-temperature process and inert gas protection of the present invention ensure that the retention rate of heat-sensitive ingredients (such as vitamin D3) is ≥95%; allergen detection (ELISA method) shows that common allergens are not detected; the gastric mucosal irritation score is low, and the safety is better than traditional inorganic salts. The special formula for pregnant women reduces the incidence of cramps during pregnancy and improves the blood calcium compliance rate; the fast-absorbing formula is adapted to the digestive characteristics of infants and young children; and the low-sodium formula effectively controls the risk of pregnancy-induced hypertension.

[0041] 4. The two-stage fermentation process and real-time ORP control in the present invention stabilize the Se-Ge-S bond formation rate at ≥85%; pulsed ultrasound combined with enzymatic hydrolysis technology ensures that the RSD of particle size between batches is ≤3.5%; the entire process is produced in a GMP clean workshop, with excellent microbial indicators, and the combination of prebiotics and minerals improves iron absorption rate; small molecule peptide encapsulation technology improves the retention rate of peptides under the action of pepsin; and the vitamin D3 microencapsulation process ensures that the activity retention rate during storage is ≥95%. DETAILED DESCRIPTION

[0042] Example 1: Basic radiation-resistant maternal and infant salt (seaweed-derived formula)

[0043] 1) Formulation:

[0044] Organic sun-dried sea salt (As ≤ 0.3 mg / kg): 99.40%

[0045] Selenium yeast (selenium content 2000μg / g): 6.5mg / kg

[0046] Organic germanium-132 (β-carboxyethyl germanium sesquioxide): 4.0 mg / kg

[0047] Seaweed calcium (calcium content 32.1%): 8.0 mg / kg

[0048] Marine collagen oligopeptide (450Da): 6.0mg / kg

[0049] Carboxylated chitosan-modified nanohydroxyapatite: 0.1%

[0050] 2'-fucosyllactose (HMO): 0.25%

[0051] Ascorbyl palmitate: 0.08%

[0052] 2) Preparation method:

[0053] Step 1: Strain domestication: Lactobacillus plantarum was gradually adapted to culture in MRS medium containing 0.2 mmol / L sodium selenite to obtain a selenium-tolerant strain (selenium tolerance increased 5-fold);

[0054] Step 2: Two-stage fermentation:

[0055] Phase 1: Selenium-resistant bacteria are mixed with selenium yeast and seaweed calcium and fermented at 37°C and pH 4.8 for 24 hours;

[0056] The second stage: add organic germanium-132, control ORP-180mV, and continue fermentation for 48h;

[0057] Step 3, ultrasound-enzymatic assembly: the fermentation product, nanohydroxyapatite, and bromelain (0.05%) were treated with ultrasound pulses at 35 kHz / 400 W (5 s on / 2 s off) for 45 min;

[0058] Step 4: Low-temperature spray drying: inlet air temperature 45°C, outlet moisture ≤ 5%;

[0059] Step 5: Final mixing: Mix with organic sea salt, HMO, etc. under nitrogen protection for 25 minutes;

[0060] Step 6. Packaging: Light-proof aluminum foil bag filled with nitrogen and sealed, sterilized by ultraviolet light (8mJ / cm 2 ).

[0061] 3) Experimental conditions:

[0062] Fermentation system: Dissolved oxygen ≥30%; ultrasonic equipment: Sonics VCX750, ±1℃ water bath temperature control; testing environment: 25±2℃, humidity 50±5%.

[0063] 4) Experimental data:

[0064] Test items result Testing standards Se-Ge-S bond formation rate 87.5±1.2% (HPLC) GB5009.93 Average particle size 48±3nm ISO22412 Calcium bioavailability (rat) 43.2±2.0％ GB5009.92 4h selenium sustained release rate (simulated gastric fluid) 82.3±1.5％ USP<711> Free radical scavenging rate (DPPH) 86.7±0.8％ GB5009.268

[0065] Example 2: Plant fermentation type radiation-resistant salt (soybean peptide carrier)

[0066] 1) Formulation:

[0067] Organic rock salt: 99.35%

[0068] Soy peptide-selenium chelate (selenium content 5.2%): 7.0 mg / kg

[0069] Yeast β-glucan germanium (germanium content 3.8%): 5.5 mg / kg

[0070] Germinated brown rice peptide (380Da): 6.5mg / kg

[0071] Nanohydroxyapatite (unmodified): 0.08%

[0072] Galacto-oligosaccharides: 0.3%

[0073] Natural tocopherols: 0.1%

[0074] 2) Preparation method:

[0075] Step 1: Fermentation optimization: Co-fermentation with Aspergillus oryzae and Lactobacillus plantarum (3:1), pre-fermentation at 30°C for 24 hours, then adding selenium / germanium source, and fermentation at 38°C for 60 hours;

[0076] Step 2, nanoloading: fermentation products and nanohydroxyapatite were continuously treated under 40kHz / 350W ultrasound for 30min;

[0077] Step 3: Low temperature drying: vacuum drying at 40°C (-0.08MPa) until the moisture content is ≤5%;

[0078] Final mixing and packaging are the same as in Example 1.

[0079] 3) Experimental conditions:

[0080] Fermentation system: BIOTECH-2005JS parallel fermenter (pH automatic control ±0.1);

[0081] Ultrasonic equipment: NanoDeBee ultrasonic cell disruptor (40 kHz / 350 W, ±2°C water bath);

[0082] Testing environment: 25±1℃, humidity 50±3%, cleanliness level 100,000;

[0083] Key parameters: Fermentation ORP was controlled at -160 to -200 mV (real-time monitoring); ultrasonic mode was continuous, and the defoamer addition amount was 0.03%.

[0084] 4) Experimental data:

[0085] Test items result Remark Selenium-germanium complex conversion rate 90.1±0.9% (HPLC) Compared with single selenium fermentation +85.2% Allergens (gluten / dairy) Not detected (ELISA) Detection limit <0.5μg / g 6-month selenium retention rate (40℃) 88.3±0.7％ Accelerated testing

[0086] Example 3: High Peptide Content Radiation-Resistant Salt (Lactoferrin Peptide)

[0087] 1) Formulation:

[0088] Organic lake salt: 99.32%

[0089] Selenolactoferrin peptide (selenium 3.5%): 8.0 mg / kg

[0090] Casein phosphopeptide-germanium (germanium 2.5%): 6.0 mg / kg

[0091] Hydrolyzed lactoferrin peptide (280Da): 10.0 mg / kg

[0092] Lactose-N-neotetraose (LNnT): 0.4%

[0093] Lecithin: 0.15%

[0094] 2) Key processes:

[0095] Ultrasound-enzyme coupling: 30kHz / 300W pulsed ultrasound + trypsin (0.1%) simultaneous treatment for 60min;

[0096] Antibacterial treatment: Oxford cup method verification before packaging (Escherichia coli inhibition zone 8.2±0.5mm).

[0097] 3) Experimental conditions:

[0098] Enzymatic hydrolysis system: pH 7.0 ± 0.1 automatic control reaction tank (equipped with trypsin activity ≥ 500 U / mg);

[0099] Antibacterial verification: Oxford cup method (37℃ / 24h), the strain is Escherichia coli ATCC25922;

[0100] Drying process: Freeze drying (Christ Alpha 2-4 LD plus, -40 ° C pre-freezing, vacuum degree 0.05 mbar). 4) Experimental data:

[0101] Test items result Standard requirements Peptide retention (pepsin) 91.5±1.0％ ≥85％ Peak time (rat plasma) 2.8±0.3h Ordinary selenium salt 4.5h

[0102] Example 4: Anti-radiation low-sodium salt for pregnant women

[0103] 1) Formula composition:

[0104] Low sodium rock salt (NaCl 70%, KCl 30%): 99.28%

[0105] Fucoidan-selenium complex (selenium 6.0%): 7.5 mg / kg

[0106] Seaweed germanium (germanium 4.2%): 5.0 mg / kg

[0107] Vitamin D3 microcapsules (100,000 IU / g): 0.1%

[0108] HMO mixture (2'-FL+LNnT): 0.35%

[0109] 2) Key processes:

[0110] Microencapsulation process: W / O / W double emulsification method (IKAT25 homogenizer, 12000rpm×3min); packaging sterilization: UV dose 10mJ / cm 2 (UV-340A calibration).

[0111] 3) Clinical effect (double-blind trial, n=50):

[0112] index experimental group Control group (ordinary low sodium salt) P-value Incidence of pregnancy-induced hypertension 5％ 19％ ＜0.01 Blood calcium standard rate (late pregnancy) 94％ 68％ ＜0.001

[0113] Control Example 1: Inorganic salt control formula

[0114] 1) Recipe:

[0115] Refined table salt (GB2721): 99.7%;

[0116] Sodium selenite: 6.0 mg / kg;

[0117] Calcium carbonate: 8.0 mg / kg;

[0118] Maltodextrin: 0.3%.

[0119] 2) Preparation: Dry mixing, without controlling temperature and humidity (measured RH 60%).

[0120] 3) Experimental conditions:

[0121] Mixing equipment: V-type mixer (speed 20 rpm, room temperature 25°C);

[0122] Packaging: Ordinary PE bag (humidity not controlled, measured RH45-65%);

[0123] Detection method: Same as Example 1 (GB5009. series).

[0124] 4) Data comparison:

[0125] index Example 1 Comparative Example 1 Improvement effect Calcium absorption rate 43.2％ 22.5％ +92％ Gastric mucosal injury score (0-4) 0.5 2.3 78% reduction

[0126] Control Example 2: Simple Mixture of Organic Salts

[0127] 1) Formulation: Same as Example 1, except that the fermentation and ultrasonic steps were omitted.

[0128] 2) Preparation: three-dimensional mixer (30°C x 40 min, not nitrogen-filled).

[0129] 3) Data comparison:

[0130] index Example 1 Comparative Example 2 Reasons for the difference Average particle size 48nm 320nm Lack of nanoassembly technology 6-month selenium retention rate 89.2％ 71.5％ Se-Ge-S bond not formed

[0131] The data comparison table of Examples 1-4, Comparative Examples 1-2 and industry standards is as follows:

[0132] Example 1-4 data:

[0133]

[0134] Comparative Example 1-2 data:

[0135] Core indicators Comparative Example 1 Comparative Example 2 Industry Standard (Infant and Young Children's Food) Mineral bioavailability (calcium) 22.5±3.0％ 35.1±2.5％ ≥30% (calcium) Free radical scavenging rate (DPPH method) 45.0±2.5％ 62.0±2.0％ No requirements Allergen detection (ELISA method) 7.8±1.2μg / g 3.5±0.8μg / g <1 μg / g Inter-batch RSD (particle size) 8.5±1.5％ 6.2±1.0％ ≤10％ 6-month selenium retention rate 65.0±3.0％ 71.5±2.5％ No requirements Gastric mucosal irritation score (0-4) 2.3±0.3 1.8±0.2 ≤1.0 (recommended)

[0136] From the above data comparison table, it can be seen that the embodiments of the present invention have the following advantages: 1) high bioavailability and efficient absorption:

[0137] Calcium absorption rate is significantly improved: The calcium bioavailability of Examples 1-4 exceeds 40%, nearly double that of traditional inorganic salts, and better than that of simple mixed organic salts;

[0138] Excellent sustained-release performance of minerals: the sustained-release rate of selenium in simulated gastric fluid is 82.3±1.5% in 4 hours (Example 1), and the intestinal release rate is ≥90% in 24 hours, avoiding the metabolic burden caused by sudden release and significantly improving the absorption efficiency.

[0139] 2) Excellent anti-radiation and anti-oxidation capabilities:

[0140] High free radical scavenging rate: The free radical scavenging rate (DPPH method) of Examples 1-4 was stable at 85%-88%, which was approximately 93% and 40% higher than that of inorganic salts (45.0±2.5%) and simple mixed organic salts (62.0±2.0%), respectively;

[0141] Synergistic effect of Se-Ge-S complex: The conversion rate of the selenium-germanium complex of Example 2 reaches 90.1±0.9%, which is significantly higher than that of a single component (85.2%), ensuring long-term anti-radiation function.

[0142] 3) Industry-leading stability and security

[0143] Strong long-term stability: After 6 months of accelerated testing, the selenium retention rate remained at 88.3±0.7%-90.1±0.6% (Examples 2-3), far exceeding the control (65.0±3.0%-71.5±2.5%)

[0144] Safety standards are fully met: no allergens were detected in all examples (ELISA method, detection limit <0.5μg / g), the gastric mucosal irritation score was only 0.4-0.6 (industry recommended value ≤1.0), and the microbial index was ≤15CFU / g, far exceeding the industry standard.

[0145] 4) Accurately adapt to the special needs of mothers and babies

[0146] Formula for pregnant women: Clinical data from Example 4 showed that the incidence of pregnancy-induced hypertension was reduced to 5% (19% in the control group) and the blood calcium compliance rate was increased to 94% (68% in the control group);

[0147] Designed for infants and young children: The time it takes for the mineral to reach its peak is shortened to 2.8±0.3h (Example 3), which is significantly better than that of ordinary selenium salts (4.5h), and is in line with the rapid absorption characteristics of infants and young children.

[0148] 5) The process is stable and controllable:

[0149] High batch consistency: The RSD of particle size between batches of Examples 1-4 is ≤3.5% (such as Example 3 is only ≤3.0%), which is much lower than the industry standard (≤10%), ensuring product uniformity.

[0150] Low temperature activity retention: The retention rate of heat-sensitive ingredients (such as vitamin D3 and active peptides) is ≥91.5%, and the spray drying temperature is ≤45°C to avoid degradation.

[0151] Through Se-Ge-S complex generation, nanocarrier loading and low-temperature process, it is superior to the control example in all aspects and meets the special requirements of maternal and infant food.

[0152] This invention significantly enhances the mineral bioavailability and radiation protection of maternal and infant salts through the microbial synthesis of Se-Ge-S covalent complexes, targeted nanocarrier loading, and a two-stage fermentation-ultrasound assembly process. Furthermore, its hypoallergenic formulation and low-temperature processing ensure its safety for both mothers and infants. Experimental data demonstrates that this product boasts a free radical scavenging rate of ≥85%, calcium bioavailability of ≥40%, no detectable allergens, and excellent batch-to-batch stability, fully meeting the specific nutritional and health needs of mothers and infants.

[0153] The above description is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solution and inventive concept of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. Radiation-resistant organic salt for mothers and infants, characterized by: The raw materials include the following components: Organic basic salt: ≥97% by weight, selected from organic sun-dried sea salt, rock salt or lake salt; Anti-radiation mineral complex: prepared from organic iodine, organic calcium, organic selenium and organic germanium through solid-state fermentation-ultrasonic assembly process to form Se-Ge-S covalent complex, wherein: Organic iodine content is 5-10mg / Kg, selected from seaweed iodine or iodized casein; Organic calcium content is 5-10mg / Kg, selected from calcium citrate malate or seaweed calcium; Organic selenium content is 3-8mg / Kg, selected from selenium yeast or selenomethionine; Organic germanium content is 2-5 mg / Kg, selected from organic germanium-132; The free radical scavenging rate of the Se-Ge-S covalent complex is ≥85%, and the selenium sustained release rate in simulated gastric fluid over 4 hours is 80-90%; Nanocarrier: carboxylated chitosan-modified nanohydroxyapatite, with an average particle size of ≤50 nm and a zeta potential absolute value of ≥35 mV, loaded with the radiation-resistant mineral complex, with a binding rate of ≥90%; Prebiotic component: 0.1-0.5% content, selected from oligofructose or human milk oligosaccharide; Stabilizer: content 0.05-0.2%, selected from ascorbyl palmitate or natural tocopherol.

2. The radiation-resistant organic salt for mothers and infants according to claim 1, characterized in that: In the radiation-resistant mineral complex, the mass ratio of organic selenium to organic germanium is (1.5-2.0):1, and the total amount of organic iodine, organic calcium, organic selenium, and organic germanium added is ≤0.6%; The Se-Ge-S covalent complex is produced by two-stage solid-state fermentation, wherein the pH is controlled at 4.5±0.2 in the first stage and the redox potential is controlled at -150 to -200 mV in the second stage.

3. The radiation-resistant organic salt for mothers and infants according to claim 1, characterized in that: The invention also includes 0.01-0.05% of fucoidan as a radiation protection enhancer, and the mass ratio of fucoidan to Se-Ge-S complex is (0.1-0.3):

1. The free radical scavenging rate under synergistic effect is ≥85%.

4. The radiation-resistant organic salt for mothers and infants according to claim 1, characterized in that: The sustained-release rate of the anti-radiation mineral complex in a simulated infant intestinal environment (pH 6.8, 37° C.) is: selenium release ≥ 90% in 24 hours, and germanium release ≥ 80% in 24 hours.

5. The radiation-resistant organic salt for mothers and infants according to claim 1, characterized in that: The organic selenium is in the form of selenium yeast, with a selenium content of ≥2000 μg / g, and is co-cultured with organic germanium through a solid-state fermentation process, and the redox potential is controlled to be -150 to -200 mV during the fermentation process.

6. A method for preparing a radiation-resistant organic salt specifically for mothers and infants, which is applied to the radiation-resistant organic salt specifically for mothers and infants as claimed in any one of claims 1 to 5, characterized in that: The following steps are involved: Step 1: Directed bacterial acclimation: Lactobacillus plantarum is gradually adapted to culture in a medium containing 0.1-0.3 mmol / L sodium selenite to obtain a selenium-resistant strain; Step 2: Two-stage solid-state fermentation: Stage 1: Mix the activated bacteria with an organic iodine source, an organic calcium source, and selenium yeast and ferment at 37°C for 24 hours; Phase II: Add organic germanium source, control pH 4.5±0.2, redox potential -150 to -200 mV, and continue fermentation for 48 hours; Step 3: Ultrasound-enzyme coupling assembly: The fermentation product was mixed with carboxylated chitosan-modified nanohydroxyapatite and pulse-treated for 45 minutes under 30kHz / 400W ultrasound and 0.05-0.1% bromelain; Step 4: Low-temperature spray drying: inlet air temperature ≤ 45°C, outlet moisture ≤ 5%; Step 5: Compound mixing: mixing the dried product with prebiotics, stabilizers and organic basic salts under the protection of inert gas; Step 6. Packaging: Use light-proof nitrogen-filled packaging and sterilize with ultraviolet light.

7. The method for preparing the radiation-resistant organic salt for mothers and infants according to claim 6, characterized in that: In the step 3, the mass ratio of nano-hydroxyapatite to radiation-resistant mineral is 1:(0.5-1.0), and the average particle size of the final composite is ≤100 nm.

8. The method for preparing the radiation-resistant organic salt for mothers and infants according to claim 6, characterized in that: During the drying process of step 4, the material temperature is monitored in real time to be ≤45° C. and the water activity is monitored to be ≤0.55 to ensure that the retention rate of heat-sensitive components is ≥95%.

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