Gel ointment with anti-inflammatory and analgesic activity and preparation method thereof

Abstract

The invention relates to a gel ointment with anti-inflammatory and analgesic activity and a preparation method thereof. The gel ointment is prepared from the following components in parts by mass: 15-25 parts of a lycopodium clavatum extract, 5-10 parts of clove oil, 2-5 parts of glucosamine, 2-4 parts of an auxiliary agent and 60-80 parts of cassava and montmorillonite composite gel, the montmorillonite composite gel is prepared from carboxymethyl cellulose, hydroxyethyl cellulose, modified montmorillonite, tannic acid and filler. The ointment has the effect of improving the oxidation resistance and the antibacterial performance of the ointment.

Description

Technical Field

[0001] The present application relates to the field of ointments, and in particular to a gel ointment with anti-inflammatory and analgesic activity and a preparation method thereof. Background Art

[0002] People often exercise or participate in sports and other activities in their lives, which not only increases the joy of life, but also helps to strengthen the body. However, if you do not warm up sufficiently before exercise or participate in activities with high intensity, the body is prone to acute soft tissue injuries when bumped by external forces, local bleeding and inactivated cells will occur, which will cause an inflammatory reaction.

[0003] Gel ointments, when applied to injured areas, can effectively heal them, and therefore hold great promise for promoting wound healing. However, gels are often exposed to air during use, and prolonged contact with oxygen can easily lead to oxidation, inactivating their components and compromising their effectiveness. Summary of the Invention

[0004] In order to improve the above problems, the present application provides a gel ointment with anti-inflammatory and analgesic activity and a preparation method thereof.

[0005] In the first aspect, the present application provides a gel ointment with anti-inflammatory and analgesic activity, which adopts the following technical solution: a gel ointment with anti-inflammatory and analgesic activity, comprising the following components in parts by weight: 15-25 parts of eloquentia extract, 5-10 parts of clove oil, 2-5 parts of glucosamine, 2-4 parts of auxiliary agent, and 60-80 parts of cassava and montmorillonite composite gel; The montmorillonite composite gel comprises carboxymethyl cellulose, hydroxyethyl cellulose, modified montmorillonite, tannic acid and filler.

[0006] By adopting the above technical solution, carboxymethyl cellulose is an important derivative of cellulose with good biocompatibility and safety. The introduction of hydroxyethyl cellulose can effectively improve the cross-linking performance and water absorption performance of carboxymethyl cellulose. Modified montmorillonite is also added to the gel. Montmorillonite is a natural clay mineral rich in silicon, aluminum and other elements. It also has good biocompatibility and can improve the performance of the hydrogel. At the same time, tannic acid is added to further enhance the overall antioxidant properties of the gel, and fillers are added to effectively enhance the mechanical strength of the gel system, thereby improving the stability of the prepared gel ointment.

[0007] Preferably, the modified montmorillonite raw material includes montmorillonite, calcium oxide and acrylic acid.

[0008] By adopting the above technical solution, acrylic acid-modified calcium-based montmorillonite is prepared by reacting calcium oxide and montmorillonite, which can effectively increase the specific surface area of ​​montmorillonite, thereby making the gel system have a good network system and dispersion performance. The double bond of acrylic acid is then introduced into the montmorillonite, which improves the dispersion performance of the montmorillonite and further improves the overall stability of the gel system.

[0009] Preferably, the modified montmorillonite is prepared by the following method: Montmorillonite and calcium oxide are mixed, added into water and stirred evenly, reacted after heating, filtered, washed, and dried to obtain calcium-based montmorillonite; the calcium-based montmorillonite is dispersed in cyclohexane, heated and stirred to obtain a montmorillonite dispersion, acrylic acid and anhydrous ethanol are added to the montmorillonite dispersion, stirred, filtered, washed, and dried to obtain modified montmorillonite.

[0010] By adopting the above technical solution, the specific surface area of ​​montmorillonite is reduced through the semi-dry method of calcium oxide, but the pore size is increased, and the double bonds of acrylic acid are introduced into montmorillonite by ion exchange, thereby improving the dispersion performance of montmorillonite in the gel system and further improving the compatibility and binding performance of montmorillonite, thereby improving the connection stability between the systems and further improving the stability of the gel ointment.

[0011] Preferably, the mass ratio of the montmorillonite, calcium oxide and acrylic acid is 1:(0.4-0.6):1.4.

[0012] By adopting the above technical solution, the mass ratio of montmorillonite, calcium oxide and acrylic acid is preferably within the above range, which can further improve the overall stability of the prepared modified montmorillonite.

[0013] Preferably, the montmorillonite composite gel is prepared by the following method: Carboxymethyl cellulose is mixed with water, hydroxyethyl cellulose is added, and modified montmorillonite is added after stirring. After uniform mixing, filler is added and stirred. Ammonium acrylate, potassium persulfate and N,N'-methylenebisacrylamide are added for reaction. After defoaming, the mixture is poured into a mold, heated for reaction, and washed to obtain a prefabricated gel. Tannic acid is mixed with water to obtain a tannic acid dispersion. The prefabricated gel is immersed in the tannic acid dispersion and washed to obtain a montmorillonite composite gel.

[0014] By adopting the above technical solution, a precursor is prepared by modifying montmorillonite, carboxymethyl cellulose, hydroxyethyl cellulose and filler. Montmorillonite can further improve the compatibility of the gel system and can serve as a cross-linking agent to improve the overall mechanical properties of the gel system. At the same time, fillers are added to reinforce the gel system, further improving the overall stability and mechanical strength of the gel system. Finally, tannic acid is introduced to prevent the gel groups from being restricted by the phenol groups of tannic acid in the binding of free radicals, and to improve the overall antioxidant and antibacterial properties of the gel system.

[0015] Preferably, the filler raw materials include silver nitrate, glucose and polyvinyl pyrrolidone.

[0016] By adopting the above technical solution, modified nanosilver particles are prepared using silver nitrate, glucose and polyvinyl pyrrolidone as raw materials. The nanosilver has good chemical stability and good mechanical strength, and can further reinforce the gel system, thereby improving the overall mechanical strength of the gel system. In addition, the prepared nanosilver particles have good antibacterial properties and can synergistically inhibit bacteriostasis with tannic acid, thereby further improving the overall antibacterial properties of the gel ointment.

[0017] Preferably, the filler is prepared by the following method: Silver nitrate is mixed with water to obtain a silver nitrate solution; glucose, polyvinyl pyrrolidone and water are mixed to obtain a glucose dispersion, the glucose dispersion is heated and stirred, the silver nitrate solution is added to the glucose dispersion for reaction, the supernatant is removed after centrifugation, and the filler is washed and dried.

[0018] By adopting the above technical solution, silver nitrate is used as a precursor, glucose as a reducing agent, and polyvinyl pyrrolidone as a modifier, and a liquid phase reduction method is used in an aqueous phase system to prepare nanosilver powder, which is a filler. The prepared filler has a uniform particle size and good dispersibility, and can be more stable in the system, thereby further improving the overall stability and mechanical strength of the gel ointment, and further improving the overall antibacterial performance of the system.

[0019] Preferably, the mass ratio of the silver nitrate to the polyvinyl pyrrolidone is 1:(0.08-0.12).

[0020] By adopting the above technical solution, preferably the mass ratio between silver nitrate and polyvinyl pyrrolidone is within the above range, which can further improve the stability of the prepared filler.

[0021] Preferably, the mass ratio of the modified montmorillonite, carboxymethyl cellulose and tannic acid is 1:(0.4-0.5):0.2.

[0022] By adopting the above technical solution, the mass ratio of modified montmorillonite, carboxymethyl cellulose and tannin is preferably within the above range, which can further improve the overall stability of the prepared gel system.

[0023] In a second aspect, the present application provides a method for preparing a gel ointment having anti-inflammatory and analgesic activity, using the following technical solution: A method for preparing a gel ointment having salt-resistant analgesic activity comprises the following steps: The montmorillonite composite gel, eugenol extract, clove oil, glucosamine, adjuvant and water are mixed, and the mixture is heated and stirred to obtain a gel ointment with anti-inflammatory and analgesic activities.

[0024] In summary, this application includes at least one of the following beneficial technical effects: 1. Carboxymethyl cellulose is used as the matrix. After the introduction of hydroxyethyl cellulose, the compatibility of carboxymethyl cellulose can be effectively improved, and the cross-linking performance of carboxymethyl cellulose can be enhanced, thereby improving the overall stability of the prepared gel ointment. At the same time, modified montmorillonite is also added. Montmorillonite is a natural clay mineral that is rich in silicon, aluminum and other elements and also has good biocompatibility to enhance the performance of the gel. Fillers are also added to fill the gel, thereby improving the overall stability of the gel system. Tannic acid is also added. Tannic acid has good antioxidant and antibacterial properties, which can further enhance the overall comprehensive performance of the system. 2. The calcium oxide semi-dry process reduces the specific surface area of ​​the montmorillonite and increases the pore size. The double bonds of acrylic acid are introduced into the montmorillonite through ion exchange, thereby enhancing the overall dispersion performance of the montmorillonite and further improving the compatibility of the montmorillonite, thereby increasing the stability of the gel ointment. 3. Using silver nitrate as a precursor, glucose as a reducing agent, and polyvinyl pyrrolidone as a modifier, nanosilver powder was prepared by liquid phase reduction method in an aqueous phase system. It was added to the gel system as a filler. The particle size is uniform and it has good non-bacterial performance. At the same time, it can synergistically improve the overall antibacterial performance of the system with tannic acid. DETAILED DESCRIPTION

[0025] The present application is further described in detail below with reference to the embodiments: Raw materials: All raw materials in the examples are commercially available; the auxiliary agent is sorbitol (CAS No.: 50-70-4), a humectant.

[0026] Example 1 Preparation of modified montmorillonite: 50 g of montmorillonite (CAS No.: 1318-93-0) was mixed with 20 g of calcium oxide, added to 800 g of deionized water and stirred evenly, then reacted in an oven at 60 ° C for 12 h, ground after the reaction, filtered, and the excess calcium oxide was washed, and dried in an oven at 60 ° C for 6 h to obtain calcium-based montmorillonite; the calcium-based montmorillonite was dispersed in 300 g of cyclohexane (CAS No.: 110-82-7), stirred at 79 ° C and 600 rpm for 10 min to obtain a montmorillonite dispersion, 70 g of acrylic acid (CAS No.: 79-10-7) and 80 g of anhydrous ethanol were added to the montmorillonite dispersion, stirred for 3 h, filtered, washed with ethanol, and then dried in an oven at 60 ° C for 8 h to obtain modified montmorillonite.

[0027] Prepare the filler: 56.3 g of silver nitrate was mixed with 200 g of deionized water to obtain a silver nitrate solution; 40 g of glucose (CAS number: 58367-01-4) and 3.7 g of polyvinyl pyrrolidone (CAS number: 9003-39-8) were mixed with 200 g of deionized water, and the pH value of the system was adjusted to 9 with sodium hydroxide to obtain a glucose dispersion. The glucose dispersion was heated to 90° C. and kept at a constant temperature for 30 minutes, and then the silver nitrate solution was added to the glucose dispersion for reaction. After the reaction, the mixture was centrifuged, the supernatant was removed, and the mixture was centrifuged and washed with ethanol. After washing, the mixture was dried in an oven, ground, and dried in an oven at 80° C. for 12 hours to obtain a filler.

[0028] Preparation of montmorillonite composite gel: 62.5 g of carboxymethyl cellulose (CAS No.: 9000-11-7) was mixed with 500 g of deionized water, and then 19.8 g of hydroxyethyl cellulose (CAS No.: 9004-62-0) was added and stirred at 300 rpm. 25 g of modified montmorillonite was added and stirred. After that, 12.5 g of filler was added. After stirring, 180 g of ammonium acrylate (CAS No.: 10604-69-0) was added, and finally 240 g of potassium persulfate (CAS No.: 7727-21- 1) reacting with 120 g of N,N'-methylenebisacrylamide (CAS No.: 110-26-9), followed by vacuum defoaming, pouring into a mold, reacting in an oven at 65°C under nitrogen protection for 12 hours, and washing with deionized water to obtain a prefabricated gel; mixing tannic acid (CAS No.: 1401-55-4) with deionized water to obtain a tannic acid dispersion with a mass fraction of 30%, immersing the prefabricated gel in the tannic acid dispersion for 48 hours, and then washing with deionized water to obtain a montmorillonite composite gel.

[0029] Preparation of gel ointment with anti-inflammatory and analgesic activity: 60 g of montmorillonite composite gel, 15 g of clematis extract, 5 g of clove oil (CAS No.: 8000-34-8), 2 g of glucosamine (CAS No.: 3416-24-8), 2 g of auxiliary agent and 20 g of purified water were mixed, heated to 60°C, and stirred at a stirring speed of 300 rpm for 3 hours to obtain a gel ointment with anti-inflammatory and analgesic activity.

[0030] Example 2 Preparation of modified montmorillonite: 50 g of montmorillonite was mixed with 30 g of calcium oxide, added to 800 g of deionized water and stirred evenly, then reacted in an oven at 60°C for 12 h, ground after the reaction, filtered, and the excess calcium oxide was washed, and dried in an oven at 60°C for 6 h to obtain calcium-based montmorillonite; the calcium-based montmorillonite was dispersed in 300 g of cyclohexane, stirred at 79°C and 600 rpm for 10 min to obtain a montmorillonite dispersion, 70 g of acrylic acid and 80 g of anhydrous ethanol were added to the montmorillonite dispersion, stirred for 3 h, filtered, washed with ethanol, and then dried in an oven at 60°C for 8 h to obtain a modified montmorillonite.

[0031] Prepare the filler: 44.64 g of silver nitrate was mixed with 200 g of deionized water to obtain a silver nitrate solution; 40 g of glucose, 5.36 g of polyvinyl pyrrolidone and 200 g of deionized water were mixed, and the pH value of the system was adjusted to 10 with sodium hydroxide to obtain a glucose dispersion. The glucose dispersion was heated to 90° C. and kept at a constant temperature for 30 minutes. Then, the silver nitrate solution was added to the glucose dispersion for reaction. After the reaction, the mixture was centrifuged, the supernatant was removed, and the mixture was centrifuged and washed with ethanol. After washing, the mixture was dried in an oven, ground, and dried in an oven at 80° C. for 12 hours to obtain a filler.

[0032] Preparation of montmorillonite composite gel: 58.82 g of carboxymethyl cellulose was mixed with 500 g of deionized water, and then 19.8 g of hydroxyethyl cellulose was added and stirred at a speed of 300 rpm. 29.42 g of modified montmorillonite was added and stirred evenly. 11.76 g of filler was added and stirred, and then 180 g of ammonium acrylate was added. Finally, 240 g of potassium persulfate and 120 g of N,N'-methylenebisacrylamide were added for reaction, and then vacuum defoaming was carried out. After pouring into a mold, the mixture was reacted in an oven at 65°C under nitrogen protection for 12 hours, and washed with deionized water to obtain a prefabricated gel. Tannic acid was mixed with deionized water to obtain a tannic acid dispersion with a mass fraction of 30%. The prefabricated gel was immersed in the tannic acid dispersion and soaked for 48 hours. Then, it was washed with deionized water to obtain a montmorillonite composite gel.

[0033] Preparation of gel ointment with anti-inflammatory and analgesic activity: 80 g of montmorillonite composite gel, 25 g of clematis extract, 10 g of clove oil, 5 g of glucosamine, 4 g of auxiliary agent and 30 g of purified water were mixed, heated to 60°C, and stirred at a stirring speed of 300 rpm for 3 h to obtain a gel ointment with anti-inflammatory and analgesic activity.

[0034] Example 3 Preparation of modified montmorillonite: 50 g of montmorillonite was mixed with 25 g of calcium oxide, added to 800 g of deionized water and stirred evenly, then reacted in an oven at 60°C for 12 h, ground after the reaction, filtered, and the excess calcium oxide was washed, and dried in an oven at 60°C for 6 h to obtain calcium-based montmorillonite; the calcium-based montmorillonite was dispersed in 300 g of cyclohexane, stirred at 79°C and 600 rpm for 10 min to obtain a montmorillonite dispersion, 70 g of acrylic acid and 80 g of anhydrous ethanol were added to the montmorillonite dispersion, stirred for 3 h, filtered, washed with ethanol, and then dried in an oven at 60°C for 8 h to obtain a modified montmorillonite.

[0035] Prepare the filler: 45.45 g of silver nitrate was mixed with 200 g of deionized water to obtain a silver nitrate solution; 40 g of glucose, 4.55 g of polyvinyl pyrrolidone and 200 g of deionized water were mixed, and the pH value of the system was adjusted to 9.5 using sodium hydroxide to obtain a glucose dispersion. The glucose dispersion was heated to 90° C. and kept at a constant temperature for 30 minutes. Then, the silver nitrate solution was added to the glucose dispersion for reaction. After the reaction, the dispersion was centrifuged, and the supernatant was removed. The dispersion was washed by centrifugation with ethanol, dried in an oven after washing, ground, and dried in an oven at 80° C. for 12 hours to obtain a filler.

[0036] Preparation of montmorillonite composite gel: 60.61 g of carboxymethyl cellulose was mixed with 500 g of deionized water, and then 19.8 g of hydroxyethyl cellulose was added and stirred at a speed of 300 rpm. 27.27 g of modified montmorillonite was added and stirred evenly. 12.12 g of filler was added and stirred. 180 g of ammonium acrylate was added, and finally 240 g of potassium persulfate and 120 g of N,N'-methylenebisacrylamide were added for reaction. The mixture was then vacuum defoamed and poured into a mold. The mixture was reacted in an oven at 65°C under nitrogen protection for 12 hours. The mixture was washed with deionized water to obtain a prefabricated gel. Tannic acid was mixed with deionized water to obtain a tannic acid dispersion with a mass fraction of 30%. The prefabricated gel was immersed in the tannic acid dispersion and soaked for 48 hours. The mixture was then washed with deionized water to obtain a montmorillonite composite gel.

[0037] Preparation of gel ointment with anti-inflammatory and analgesic activity: 70 g of montmorillonite composite gel, 20 g of clematis extract, 7 g of clove oil, 4 g of glucosamine, 3 g of auxiliary agent and 25 g of purified water were mixed, heated to 60°C, and stirred at a stirring speed of 300 rpm for 3 h to obtain a gel ointment with anti-inflammatory and analgesic activity.

[0038] Example 4 Example 4 is based on Example 3. In Example 4, 15 g of calcium chloride is used in preparing the modified montmorillonite.

[0039] Example 5 Example 5 is based on Example 3. In Example 5, 35 g of calcium chloride is used to prepare the modified montmorillonite.

[0040] Example 6 Example 6 is based on Example 3. In Example 6, 47.17 g of silver nitrate and 2.83 g of polyvinyl pyrrolidone are used in preparing the filler.

[0041] Example 7 Example 7 is based on Example 3. In Example 7, 43.86 g of silver nitrate and 6.14 g of polyvinyl pyrrolidone are used in preparing the filler.

[0042] Example 8 Example 8 is based on Example 3, and the filler in Example 8 is ordinary unmodified nano silver oxide.

[0043] Example 9 Example 9 is based on Example 3. In Example 9, when preparing the montmorillonite composite gel, 66.67 g of carboxymethyl cellulose, 20 g of modified montmorillonite, and 13.33 g of filler are used.

[0044] Example 10 Example 10 is based on Example 3. In Example 10, when preparing the montmorillonite composite gel, 55.56 g of carboxymethyl cellulose, 33.33 g of modified montmorillonite, and 11.11 g of filler are used.

[0045] Example 11 Example 11 is based on Example 3. In Example 11, when preparing the montmorillonite composite gel, the tannic acid dispersion is added after the filler is added.

[0046] Example 12 Example 12 is based on Example 3. In Example 12, when preparing the montmorillonite composite gel, the prefabricated gel is not added to the tannic acid dispersion for immersion.

[0047] Comparative Example 1 Comparative Example 1 is based on Example 3. In Comparative Example 1, when preparing the montmorillonite composite gel, the modified montmorillonite is replaced by ordinary montmorillonite.

[0048] Comparative Example 2 Comparative Example 2 is based on Example 3. In Comparative Example 2, no filler is added when preparing the montmorillonite composite gel.

[0049] Performance testing The samples of Examples 1-12 and Comparative Examples 1-2 were sampled and subjected to the following performance tests: (1) Antioxidant properties Accurately weigh 0.039 g of DPPH, use 95% ethanol to make up to 50 mL, and then dilute 10 times to obtain 0.6 mmol / L DPPH. Take 10 mL and add it to the facial mask. Incubate in the dark for 30 min, take 2 mL and measure the optical density at 517 nm. Use deionized water instead of the facial mask as the negative control group. DPPH free radical scavenging efficiency (%) = [1-(optical density value of the experimental group / optical density value of the control group)] × 100%; each sample is tested 3 times, the average value is taken, and the test results are filled in Table 1.

[0050] (2) Antibacterial properties The antibacterial properties of the samples were tested, each sample was tested 3 times, the average value was taken, and the test results were filled in Table 1.

[0051] Table 1 Performance test results of Examples 1-12 and Comparative Examples 1-2 Combined with Table 1, it can be seen that the DPPH free radical scavenging efficiency of Examples 1-3 is 94.5% or above, indicating that the gel prepared in the present application has good antioxidant properties. The antibacterial rates of Escherichia coli in Examples 1-3 are all 99.4% or above, and the antibacterial rates of Staphylococcus aureus are all 99.6% or above, indicating that the gel ointment prepared in the present application has good antibacterial properties.

[0052] In Examples 4 and 5, when preparing modified montmorillonite, the mass ratio of calcium chloride to montmorillonite was not within the range specified in the present application. When the calcium chloride content was too low, it was difficult to further modify the surface of the montmorillonite and introduce the double bonds of acrylic acid. The reactivity of the montmorillonite decreased, and the compatibility was also affected, resulting in a decrease in the stability of the prepared montmorillonite composite gel. When the calcium chloride content was too high, the pore size of the montmorillonite was too large, resulting in a decrease in the overall stability of the montmorillonite. Therefore, the stability of the prepared montmorillonite composite gel was affected, affecting the overall stability of the system.

[0053] In Examples 6 and 7, when preparing the filler, the mass ratio of silver nitrate to polyvinyl pyrrolidone was not within the range specified in the present application. When the content of polyvinyl pyrrolidone was too low, the modification effect on the nanosilver particles was difficult to further improve, the particle size of the nanosilver particles was too small, and agglomeration occurred in the system, affecting the overall stability of the system. When the amount of polyvinyl pyrrolidone used was too high, the particle size of the generated nanosilver particles was different, affecting the overall stability of the system. Therefore, the performance of Examples 6 and 7 was reduced.

[0054] The filler in Example 8 is unmodified nanosilver particles. The dispersion performance of ordinary nanosilver ions in the system is difficult to improve, and agglomeration occurs in the system, affecting the overall stability of the system. Therefore, the performance of Example 8 is reduced.

[0055] In Examples 9 and 10, when preparing the montmorillonite composite gel, the mass ratios of carboxymethyl cellulose, modified montmorillonite and filler are not within the range specified in this application. When the content of modified montmorillonite is too little or too much, the swelling equilibrium performance of the gel system is reduced, affecting the overall stability of the system. When the filler is reduced, it is difficult to further improve the overall stability of the gel system. When there is too much filler, it is difficult to disperse evenly in the system, which will also affect the overall stability of the system. Therefore, the performance of Examples 9 and 10 is reduced.

[0056] In Example 11, when preparing the montmorillonite composite gel, the tannic acid dispersion was added to the system when preparing the prefabricated gel. The phenol groups in the tannic acid restricted the free radical polymerization of the gel, and the stability of the system decreased, so the performance of Example 11 decreased.

[0057] In Example 12, when preparing the montmorillonite composite gel, the prefabricated gel was not added to the tannic acid dispersion for immersion. As a result, the adhesion, antioxidant and antibacterial properties of the gel system were difficult to improve, and the overall stability of the system was affected. Therefore, the performance of Example 12 was reduced.

[0058] In Comparative Example 1, when preparing the montmorillonite composite gel, the modified montmorillonite was replaced with ordinary unmodified montmorillonite. The pore size of the unmodified montmorillonite was difficult to further improve, and the swelling performance of the system decreased, and the compatibility also decreased, affecting the overall stability of the system.

[0059] In Comparative Example 2, no filler was added when preparing the montmorillonite composite gel. The stability of the gel system without filler was difficult to further improve. At the same time, without the addition of nanosilver particles, it was difficult to combine with tannic acid to improve the overall antibacterial performance of the system. Therefore, the performance of Comparative Example 2 decreased.

[0060] This specific embodiment is merely an explanation of the present application and does not limit the present application. Based on the above description, relevant personnel can make various changes and modifications without departing from the technical scope of the present application. The technical scope of the present application is not limited to the contents of the specification and must be determined according to the scope of the claims.

Claims

1. A gel ointment with anti-inflammatory and analgesic activity, characterized in that: The composition includes the following components in parts by mass: 15-25 parts of eloneur lycopersicum extract, 5-10 parts of clove oil, 2-5 parts of glucosamine, 2-4 parts of auxiliary agent, and 60-80 parts of cassava and montmorillonite composite gel; The montmorillonite composite gel comprises carboxymethyl cellulose, hydroxyethyl cellulose, modified montmorillonite, tannic acid and filler.

2. The gel ointment having anti-inflammatory and analgesic activity according to claim 1, wherein: The modified montmorillonite raw materials include montmorillonite, calcium oxide and acrylic acid.

3. The gel ointment having anti-inflammatory and analgesic activity according to claim 2, characterized in that: The modified montmorillonite is prepared by the following method: Montmorillonite and calcium oxide are mixed, added into water and stirred evenly, reacted after heating, filtered, washed, and dried to obtain calcium-based montmorillonite; the calcium-based montmorillonite is dispersed in cyclohexane, heated and stirred to obtain a montmorillonite dispersion, acrylic acid and anhydrous ethanol are added to the montmorillonite dispersion, stirred, filtered, washed, and dried to obtain modified montmorillonite.

4. The gel ointment having anti-inflammatory and analgesic activity according to claim 3, characterized in that: The mass ratio of the montmorillonite, calcium oxide and acrylic acid is 1:(0.4-0.6):1.

4.

5. The gel ointment with anti-inflammatory and analgesic activity according to claim 1, characterized in that: The montmorillonite composite gel is prepared by the following method: Carboxymethyl cellulose is mixed with water, hydroxyethyl cellulose is added, and modified montmorillonite is added after stirring. After uniform mixing, filler is added and stirred. Ammonium acrylate, potassium persulfate and N,N'-methylenebisacrylamide are added for reaction. After defoaming, the mixture is poured into a mold, heated for reaction, and washed to obtain a prefabricated gel. Tannic acid is mixed with water to obtain a tannic acid dispersion. The prefabricated gel is immersed in the tannic acid dispersion and washed to obtain a montmorillonite composite gel.

6. The gel ointment having anti-inflammatory and analgesic activity according to claim 5, characterized in that: The filler raw materials include silver nitrate, glucose and polyvinyl pyrrolidone.

7. The gel ointment having anti-inflammatory and analgesic activity according to claim 6, characterized in that: The filler is prepared by the following method: Silver nitrate is mixed with water to obtain a silver nitrate solution; glucose, polyvinyl pyrrolidone and water are mixed to obtain a glucose dispersion, the glucose dispersion is heated and stirred, the silver nitrate solution is added to the glucose dispersion for reaction, the supernatant is removed after centrifugation, and the filler is washed and dried.

8. The gel ointment with anti-inflammatory and analgesic activity according to claim 7, characterized in that: The mass ratio between the silver nitrate and polyvinyl pyrrolidone is 1:(0.08-0.12).

9. The gel ointment with anti-inflammatory and analgesic activity according to claim 6, characterized in that: The mass ratio of the modified montmorillonite, carboxymethyl cellulose and tannic acid is 1:(0.4-0.5):0.

2.

10. A method for preparing the gel ointment having anti-inflammatory and analgesic activity according to any one of claims 1 to 9, characterized in that: The steps include: The montmorillonite composite gel, eugenol extract, clove oil, glucosamine, adjuvant and water are mixed, and the mixture is heated and stirred to obtain a gel ointment with anti-inflammatory and analgesic activities.

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