Oral care composition and application thereof

Abstract

The invention relates to an oral care composition and application thereof. The composition is prepared from the following components in parts by weight: 0.005 to 1 part of fructus forsythiae extract, 0.05 to 1 part of radix scutellariae extract and 0.05 to 0.5 part of pearl layer powder. The composition provided by the invention has a mild mucous membrane repairing function, and also has the effects of inhibiting oral bacteria and diminishing inflammation and swelling.

Description

Technical Field

[0001] The present invention relates to the technical field of medicine and health care, and more particularly to an oral care composition and application thereof. Background Art

[0002] Oral diseases are pathological phenomena that originate in the oral cavity. Their primary causes include physical and chemical damage, pathogen infection, abnormalities in dental and maxillofacial development, and systemic diseases. Oral pathogens are the primary cause of oral diseases. Effective therapeutic and preventative measures are crucial for bacterial infections and oral inflammation. While antibiotics such as penicillin, erythromycin, tetracycline, and spiramycin have some preventative and therapeutic effects, long-term use can cause oral and intestinal flora imbalances, leading to other diseases.

[0003] Oral ulcers are a common clinical disease of the oral mucosa. They are characterized by lesions in non-keratinized areas of the oral mucosa, such as the tongue, lips, cheeks, and gums. When they develop, they present as a distinct wound, sunken in the center and surrounded by a red halo, covered by a white membrane. The wounds are usually oval or round, approximately 1-5 mm in diameter. Sometimes there is a single wound, sometimes multiple. Patients often experience a burning sensation. Oral ulcers are characterized by recurrence, self-healing, and self-limiting characteristics. Oral ulcers cannot be cured, and local treatment is the primary treatment.

[0004] In view of this, finding safe and effective oral antibacterial drugs and anti-inflammatory and detumescent drugs has become the focus of research on oral disease prevention and treatment and daily oral health and hygiene care. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide an oral care composition which is less irritating, clears away heat and fire, detoxifies and relieves pain, can prevent oral ulcers, and has the function of repairing mucosa.

[0006] In order to solve the above technical problems, the technical solution adopted by the present invention is:

[0007] The first object of the present invention is to provide an oral care composition, which comprises, by weight,:

[0008] Forsythia suspensa extract 0.005-1 part

[0009] Scutellaria baicalensis extract 0.05-1 part

[0010] 0.05-0.5 parts of pearl layer powder.

[0011] Preferably, the composition further comprises 0.005-0.5 parts of jasmine extract;

[0012] And / or, the composition further comprises 0.1-3 parts of peppermint extract;

[0013] And / or, the composition further comprises 0-0.1 parts of artificial bezoar.

[0014] Preferably, the composition comprises, by weight,

[0015]

[0016] The second object of the present invention is to provide a use of any of the above-mentioned compositions in the preparation of oral care products with mucosal repair, anti-inflammatory and detumescent effects.

[0017] The third object of the present invention is to provide a mild oral care product with mucosal repair function, which comprises any of the above-mentioned compositions and excipients.

[0018] Preferably, the product comprises a toothpaste, a mouth rinse, an oral spray or an oral patch.

[0019] Preferably, the auxiliary materials include moisturizers, preservatives, foaming agents, thickeners, abrasives, flavoring agents, sweeteners, cooling agents, appearance improvers, and cleaning aids;

[0020] Preferably, the product is toothpaste, and the humectant is selected from one or more of sorbitol, glycerin, polyethylene glycol-400, propylene glycol and polypropylene glycol;

[0021] The preservative is selected from one or more of paraben, sodium benzoate, sorbic acid and DMDMH;

[0022] The foaming agent is selected from one or more of cocamidopropyl betaine, sodium methyl cocoyl taurate, lauryl glucoside, glycolipids and lauric acid;

[0023] The thickener is selected from one or more of cellulose gum, xanthan gum, carrageenan and hydroxyethyl cellulose;

[0024] The friction agent is selected from one or more of calcium carbonate, calcium bicarbonate, calcium pyrophosphate, sodium metaphosphate and hydrated silica;

[0025] The flavoring agent is selected from one or more combinations of edible flavors, spearmint flavors, fruit flavors, and cardamom flavors;

[0026] The sweetener is selected from one or more of saccharin sodium, xylitol and erythritol;

[0027] The cooling agent is selected from one or more of menthol, menthol, WS-10 and wintergreen mint essence;

[0028] The appearance improver is selected from one or more of synthetic fluorphlogopite, mica, CI 77891, CI 19140, CI 74160 and CI16255;

[0029] The cleaning aid is selected from sodium chloride.

[0030] Preferably, the product comprises the following components in parts by weight per 100 parts:

[0031]

[0032]

[0033] Preferably, the product comprises the following components in parts by weight per 100 parts:

[0034]

[0035]

[0036] Due to the adoption of the above technical solution, the present invention has the following beneficial effects:

[0037] The present invention provides a composition containing forsythia extract, scutellaria baicalensis extract and nacre powder as effective ingredients, which has the following advantages: scientific formula, good product quality, low irritation, mildness, and the ability to reduce tooth stains and soft plaque, freshen breath, reduce bad breath, and provide a refreshing taste. At the same time, it has the effects of maintaining tooth and periodontal health and preventing oral ulcers, and is suitable for people who are prone to and frequently suffer from oral ulcers. DETAILED DESCRIPTION

[0038] To make the technical solutions and beneficial effects of the present invention more clearly understood, the following is a detailed description by listing specific embodiments. Unless otherwise defined, the technical and scientific terms used herein have the same meanings as those in the technical field to which this application belongs.

[0039] After extensive and intensive research, screening, and testing, the present inventors have developed an oral care composition with mucosal repair, anti-inflammatory, and detumescent properties. The inventors unexpectedly discovered that forsythia extract, scutellaria baicalensis extract, and nacre powder exhibit significant synergistic effects in oral care, such as anti-inflammatory, oral mucosal repair, and oral bacterial inhibition. These findings suggest that these active ingredients are highly suitable for use in the preparation of oral care products with mucosal repair, anti-inflammatory, and detumescent properties. Furthermore, the present inventors have developed oral care products, such as toothpastes and mouthwashes, containing these active ingredients. This work led to the completion of the present invention.

[0040] the term

[0041] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0042] As used herein, the terms "comprising" or "including" may be open, semi-closed, or closed. In other words, the terms also include "consisting essentially of" or "consisting of."

[0043] As used herein, when used in reference to a specific recited value, the term "about" means that the value may vary by no more than 1% from the recited value. For example, as used herein, the expression "about 100" includes all values ​​between 99 and 101 (e.g., 99.1, 99.2, 99.3, 99.4, etc.).

[0044] The first object of the present invention is to provide an oral care composition, which comprises, by weight,:

[0045] Forsythia suspensa extract 0.005-1 part

[0046] Scutellaria baicalensis extract 0.05-1 part

[0047] 0.05-0.5 parts of pearl layer powder.

[0048] The present invention first discovered that the combined use of Forsythia suspensa extract, Scutellaria baicalensis extract and nacre powder has a significant synergistic effect on oral care aspects such as anti-inflammation, oral mucosal repair and inhibition of oral bacteria, thereby providing a composition with the three as main active ingredients.

[0049] In one embodiment, the content of the Forsythia suspensa extract is 0.01, 0.015, 0.02, 0.025, 0.03, 0.035, 0.04, 0.045, 0.05, 0.055, 0.06, 0.065, 0.07, 0.075, 0.08, 0.085, 0.09, 0.095, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95, or 1 part, etc.

[0050] In one embodiment, the content of the Scutellaria baicalensis extract is 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, 0.55 part, 0.6 part, 0.65 part, 0.7 part, 0.75 part, 0.8 part, 0.85 part, 0.9 part, 0.95 part, or 1 part, etc.

[0051] In one embodiment, the content of the pearl layer powder is 0.05 parts, 0.055 parts, 0.06 parts, 0.065 parts, 0.07 parts, 0.075 parts, 0.08 parts, 0.085 parts, 0.09 parts, 0.095 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, 0.4 parts, 0.45 parts, or 0.5 parts.

[0052] The combination of active ingredients of the present invention as a whole can be used alone or in combination with other active ingredients, such as active ingredients for treating oral diseases such as anti-inflammatory, oral mucosal repair, and oral bacteria inhibition.

[0053] In one embodiment, the composition further comprises 0.005-0.5 parts (e.g., 0.006 parts, 0.007 parts, 0.009 parts, 0.01 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, 0.4 parts, 0.45 parts, etc.) of jasmine extract.

[0054] In one embodiment, the composition further comprises 0.1-3 parts (e.g., 0.1 parts, 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, etc.) of peppermint extract.

[0055] In one embodiment, the composition further comprises 0-0.1 parts (e.g., 0 parts, 0.01 parts, 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, 0.09 parts, 0.1 parts, etc.) of artificial bezoar.

[0056] In one embodiment, the composition comprises, by weight,

[0057]

[0058]

[0059] The active ingredient combination of the present invention can be used in a medicament or oral care composition as an active ingredient with mucosal repair, anti-inflammatory and detumescent effects, and antibacterial properties, and can be used to prevent or treat oral diseases (such as oral ulcers). The active ingredient combination or composition of the present invention can be used to prevent and / or treat an oral condition selected from the group consisting of tooth stains, plaque, bad breath, periodontitis, oral ulcers, or a combination thereof.

[0060] The second object of the present invention is to provide a use of any of the above-mentioned compositions in the preparation of oral care products having mucosal repair, anti-inflammatory, and / or detumescent effects.

[0061] The third object of the present invention is to provide an oral care product with mucosal repair function, which comprises any of the above-mentioned compositions and excipients.

[0062] In one embodiment, the product comprises a toothpaste, a mouth rinse, an oral spray, or an oral patch.

[0063] In one embodiment, the auxiliary materials include moisturizers, preservatives, foaming agents, thickeners, abrasives, flavoring agents, sweeteners, cooling agents, appearance improvers, and cleaning aids.

[0064] In one embodiment, the product is a toothpaste, and the humectant is selected from one or more of sorbitol, glycerin, polyethylene glycol-400, propylene glycol and polypropylene glycol;

[0065] The preservative is selected from one or more of paraben, sodium benzoate, sorbic acid and DMDMH;

[0066] The foaming agent is selected from one or more of cocamidopropyl betaine, sodium methyl cocoyl taurate, lauryl glucoside, glycolipids and lauric acid;

[0067] The thickener is selected from one or more of cellulose gum, xanthan gum, carrageenan and hydroxyethyl cellulose;

[0068] The friction agent is selected from one or more of calcium carbonate, calcium bicarbonate, calcium pyrophosphate, sodium metaphosphate and hydrated silica;

[0069] The flavoring agent is selected from one or more combinations of edible flavors, spearmint flavors, fruit flavors, and cardamom flavors;

[0070] The sweetener is selected from one or more of saccharin sodium, xylitol and erythritol;

[0071] The cooling agent is selected from one or more of menthol, menthol, WS-10 and wintergreen mint essence;

[0072] The appearance improver is selected from one or more of synthetic fluorphlogopite, mica, CI 77891, CI 19140, CI 74160 and CI 16255;

[0073] The cleaning aid is selected from sodium chloride.

[0074] In one embodiment, the product comprises the following components in parts by weight based on 100 parts:

[0075]

[0076]

[0077] In one embodiment, the content of CI 77891 is 0.01-0.05 parts.

[0078] In one embodiment, the product comprises the following components in parts by weight based on 100 parts:

[0079]

[0080]

[0081] In this application, unless otherwise specified, various raw materials and reagents are commercially available or synthesized according to known methods. In one embodiment, the scutellaria baicalensis extract, forsythia suspensa extract, etc. are extracted according to the extraction method (water extraction method) recorded in the Chinese Pharmacopoeia (2020 edition Part I).

[0082] The present invention will be further described below in conjunction with specific implementation. It should be understood that these examples are intended to illustrate the present invention only and are not intended to limit the scope of the present invention. The experimental methods in the following examples, for which specific conditions are not specified, are generally based on conventional conditions or the conditions recommended by the manufacturer. Unless otherwise stated, percentages and parts are calculated by weight.

[0083] Example 1

[0084] This embodiment provides a toothpaste, the constituent materials and the weight percentage of each material are shown in Table 1, and the balance is water.

[0085] Table 1 Test Examples 1-4 Toothpaste Composition Raw Materials and Weight Percentages

[0086]

[0087]

[0088] The toothpaste of this embodiment is prepared as known to those skilled in the art and is produced according to conventional preparation processes in the art.

[0089] The toothpastes of Examples 2-5 were prepared by referring to the method of Example 1. The constituent raw materials and the weight percentage of each raw material involved in Examples 2-5 are shown in Table 1.

[0090] The toothpastes of Comparative Examples 1-7 were prepared by referring to the method of Example 1. The constituent raw materials and the weight percentage of each raw material involved in Comparative Examples 1-7 are shown in Table 2.

[0091] Table 2 Comparative Examples 1-7 Toothpaste Composition Raw Materials and Weight Percentages

[0092]

[0093] Performance testing:

[0094] Test Example 1: Antibacterial Performance Test of Toothpastes of Examples 1-5 and Comparative Examples 1-7

[0095] The antibacterial properties of the product of the present invention were tested with reference to Article 7.9 of QB / T 2738-2023 "Evaluation Method for Antibacterial and Antibacterial Effects of Daily Chemical Products"; the test bacteria used were Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 25922, Candida albicans ATC 10231, and Pseudomonas aeruginosa ATC15442. The specific testing steps were as follows:

[0096] (1) Dilute the experimental bacterial suspension with PBS buffer to the required concentration: take 0.1 mL and drop it into 5.0 mL of the control sample solution (PBS buffer), and the number of recovered bacteria is 1×10 4 ~9×10 4 CFU / m;

[0097] (2) 10 g of each toothpaste sample of Examples 1-5 and Comparative Examples 1-7 were added to 100 mL of normal saline and mixed thoroughly to prepare the stock solution as the sample solution;

[0098] (3) Place 5 ml of the test sample stock solution or its dilution into a sterile dish and place in a (20 ± 1) °C water bath for 5 min. Use sterile tweezers to take the infected carrier and immerse it completely in the antibacterial sample. Time for 3 min.

[0099] (4) After the reaction is complete, take the infected carrier and add it to a test tube containing 5 ml of PBS and mix well;

[0100] (5) Place the plate on a vortex shaker and oscillate for 1 minute. Remove the test bacteria and draw 1 ml of the sample solution into a sterile plate. Inoculate two sterile plates with each sample solution or dilution. Pour 15-20 ml of nutrient agar (bacteria) or Sabouraud agar (Candida albicans) cooled to 40-45°C. Rotate the plate to make it fully uniform. After the agar solidifies, turn the plate over. After incubation at (36±1)°C for 48 hours (bacteria) or 72 hours (Candida albicans), count the viable colonies.

[0101] (6) Substitute PBS for the test sample and follow the above steps as the control sample.

[0102] (7) Repeat the experiment three times and calculate the arithmetic mean.

[0103] (8) The formula for calculating the antibacterial rate is: Antibacterial rate (%) = (Ⅰ-Ⅱ) / Ⅰ*100

[0104] Where, I is the average colony count of the control sample, and the unit is colony-forming unit per piece (CFU / piece);

[0105] Ⅱ is the average colony count of the test sample; the unit is colony forming unit per piece (CFU / piece);

[0106] The antibacterial performance test results are shown in Table 3.

[0107] Table 3 Antibacterial performance test results of toothpaste of the present invention

[0108]

[0109] Experimental Conclusion: The Examples and Comparative Examples 3 and 7 of the present application all had strong antibacterial effects against Staphylococcus aureus, Escherichia coli, Candida albicans, and Pseudomonas aeruginosa (inhibition rate > 90%). Comparative Examples 1, 2, and 6 had certain antibacterial effects against the above-mentioned bacterial groups (inhibition rate < 90% < 50%), but the effects were inferior to those of Examples 1-5 and Comparative Examples 3 and 7. Comparative Examples 4-5 had no antibacterial effect (inhibition rate < 50%) because they did not contain Forsythia suspensa extract or Scutellaria baicalensis extract.

[0110] Test Example 2: Anti-inflammatory Performance Test of Toothpastes of Examples 1-5 and Comparative Examples 1-7

[0111] Animal Model: 140 male Kunming mice weighing 25-30 g were selected after fasting for 12 hours and divided equally into 14 groups (blank group, model group, Example 1-5 groups, and Comparative Example 1-7 groups), with 10 mice in each group. Before the experiment, the blank group mice were given 50 μl / mouse normal saline on the front and back of the right ear. The right ears of the mice in the other groups were coated with xylene (50 μl / mouse per side) on the front and back to cause swelling and inflammation. The left ears were left untreated as a blank control.

[0112] After xylene was infused for 30 minutes, the blank group and the model group were given 50 μL of normal saline. The experimental groups (Example 1-5 groups and Comparative Example 1-7 groups) were thinly coated with an appropriate amount of toothpaste on both the inside and outside of the right ear. One hour later, the mice were killed by cervical dislocation. The two ears were cut along the baseline of the auricle, overlapped, and ear pieces of the same area were taken out with a blind puncher (diameter 7 mm) and weighed.

[0113] The formula for calculating the swelling inhibition rate of mice is:

[0114] Swelling inhibition rate (%) = [(average swelling degree of the control group - average swelling degree of the experimental group) / average swelling degree of the control group] × 100%.

[0115] The experimental results are expressed as mean ± standard deviation, and the significance test of the differences between the groups was performed using One-Way ANOVA analysis with SPSS 19.0 software. The anti-inflammatory performance test results of the toothpaste of the present invention are shown in Table 4. Compared with the model group, *P < 0.05, **P < 0.01.

[0116] Table 4 Anti-inflammatory performance test results of toothpaste of the present invention

[0117]

[0118] The experimental results show that the toothpastes prepared in Examples 1-5 and Comparative Example 7 have strong anti-inflammatory effects, with Comparative Example 7 having the strongest anti-inflammatory effect, followed by Example 4, and comparable to Examples 1-3. Comparative Examples 1, 2, and 6 also have good anti-inflammatory effects but are not as strong as Examples 1-5 and Comparative Example 7. Comparative Examples 3 and 4 have the worst anti-inflammatory effects. This shows that the Forsythia suspensa extract, Scutellaria baicalensis extract, and pearl layer powder in appropriate content ratios in Examples 1-5 have a synergistic effect when used together in the oral care composition of the present invention.

[0119] Test Example 3: Toothpaste Trial Evaluation

[0120] In order to verify the oral ulcer care effect and usage experience of the present invention, the present invention conducted a systematic human usage evaluation. Without the use of drugs for treatment, the anti-oral ulcer effect of the present invention, the onset of oral ulcers during use, the texture, taste, and foam richness of the product were evaluated.

[0121] Recruitment conditions for the trial population: Applicable subjects are those diagnosed with recurrent oral ulcers (mild oral ulcers or stomatitis oral ulcers) by Western medicine; those diagnosed with recurrent oral ulcers (mild oral ulcers and stomatitis oral ulcers) by Traditional Chinese Medicine with syndrome of heat accumulation in the heart and spleen, with symptoms of oral ulcers, pain, accompanied by irritability, hot and dry mouth, reddish and dry, yellow or greasy tongue, and thin and stringy pulse.

[0122] 120 trial subjects who met the above conditions were divided into 12 groups, with 10 subjects in each group, and were respectively tested with the compositions of Examples 1-5 and Comparative Examples 1-7; the usage and dosage were once in the morning and evening each day, with 1 cm of the paste used each time, for 3-7 days.

[0123] The evaluation indicators are:

[0124] The evaluation criteria for the paste condition (color, texture, taste) were: 1 point - very dissatisfied, 2 points - dissatisfied, 3 points - average, 4 points - satisfied, 5 points - satisfied; the average score of each group was calculated.

[0125] Oral hygiene evaluation criteria: 1 point - very dissatisfied, 2 points - dissatisfied, 3 points - average, 4 points - satisfied, 5 points - satisfied; calculate the average score of each group

[0126] The evaluation criteria for oral freshness after brushing were: 1 point - very dissatisfied, 2 points - dissatisfied, 3 points - average, 4 points - satisfied, and 5 points - satisfied; the average score of each group was calculated.

[0127] During the trial period, the speed of relief of oral ulcer pain was as follows: significantly faster (relieved within 1-3 days), slightly improved, no significant difference, and delayed relief;

[0128] The evaluation criteria for oral ulcer irritation pain during the trial period were: severe pain, severe pain, moderate pain, and mild pain.

[0129] The results of the toothpaste status, oral cleaning effect and freshness of the toothpaste trial group are shown in Table 5, the evaluation results of the oral ulcer relief speed of the toothpaste trial group are shown in Table 6, and the evaluation results of the oral ulcer irritation and pain during the trial period are shown in Table 7.

[0130] Table 5 Toothpaste trial evaluation results

[0131] Trial Products Number of trial users Paste state Oral cleaning effect Oral freshness after brushing Example 1 Toothpaste 10 3.2 3.3 2.5 Example 2 Toothpaste 10 3.4 3.6 3.8 Example 3 Toothpaste 10 3.7 4.3 4.2 Example 4 Toothpaste 10 4.2 3.8 4.5 Example 5 Toothpaste 10 3.3 3.6 2.8 Comparative Example 1 Toothpaste 10 3.4 4.1 3.3 Comparative Example 2 toothpaste 10 3.3 2.8 3.8 Comparative Example 3 toothpaste 10 3.4 3.4 4.8 Comparative Example 4 toothpaste 10 3.2 2.9 3.1 Comparative Example 5 Toothpaste 10 3.2 3.4 2.9 Comparative Example 6 Toothpaste 10 3.7 3.5 3.2 Comparative Example 7 Toothpaste 10 3.8 2.6 2.4

[0132] Judging from the results of the human trial evaluation, the scores of the paste state (taste, smell, color, texture, etc.) between the examples and the comparative examples are relatively similar. This is because, except for the differences in the content of artificial bezoar, scutellaria extract, and forsythia extract in comparative examples 1-7, the formula of other auxiliary agents is consistent with that of example 1 or 2, so the comprehensive average scores of the paste appearance are similar.

[0133] Table 6 Evaluation results of the speed of relief of oral ulcers in toothpaste trials

[0134]

[0135] From the results of the human trial experience, it can be seen that the trial users' oral ulcers were relieved faster during the use of the toothpaste products of Examples 1-5 and Comparative Examples 6-7. Comparative Examples 1-4 also had some relief, but the relief was not as good as that of Examples 1-5.

[0136] Table 7 Evaluation results of oral ulcer pain stimulation in toothpaste trials

[0137]

[0138] As shown in Table 7, during the trial, the users experienced mild or moderate pain in the oral ulcers with the toothpastes of Examples 1-5. This is because the toothpaste itself has a certain irritation to the oral ulcer wound surface, but the pain level of the toothpaste of Comparative Example 7 is more severe. It is speculated that this is because the concentration of the extract components therein is relatively high, which has a greater irritation to the oral ulcer wound surface. Correspondingly, according to the results of Table 6, the toothpaste of Comparative Example 7 also relieves oral ulcers relatively faster.

[0139] Based on the performance test results of various toothpastes and the population test results, the toothpastes of Examples 1-5 are more responsive to the trial preferences of the population.

[0140] Test Example 4: Toothpaste Quality Evaluation

[0141] The toothpaste products of Examples 1-5 of the present invention were placed at a temperature of 25°C ± 2°C and a relative humidity of 60% ± 10% for 3 months. Samples were taken at the end of the 3rd month and tested in accordance with the GBT8372-2017 "Toothpaste" standard to check whether the pH meets the requirements, whether it overflows from the tube, whether the flavor and color are normal, and whether the paste has hardened. The results are shown in Table 8.

[0142] Table 8 Quality evaluation of toothpaste of Examples 1-5

[0143] product pH Is there overflow? Fragrance and color Whether hardened Is the liquid separated? Example 1 Toothpaste Meet the requirements no normal no no Example 2 Toothpaste Meet the requirements no normal no no Example 3 Toothpaste Meet the requirements no normal no no Example 4 Toothpaste Meet the requirements no normal no no Example 5 Toothpaste Meet the requirements no normal no no

[0144] The stability test shows that the toothpaste provided by the present invention has stable quality.

[0145] It should be understood that the above embodiments are exemplary and are not intended to encompass all possible implementations of the claims. Various modifications and variations may be made to the above embodiments without departing from the scope of this disclosure. Similarly, the various technical features of the above embodiments may be arbitrarily combined to form additional embodiments of the present invention that may not be explicitly described. Therefore, the above embodiments merely illustrate several implementations of the present invention and do not limit the scope of protection of the patent of this invention.

Claims

1. An oral care composition, characterized in that According to the weight of the composition, the composition comprises: Forsythia suspensa extract 0.005-1 part Scutellaria baicalensis extract 0.05-1 part 0.05-0.5 parts of pearl layer powder.

2. The composition according to claim 1, characterized in that The composition further comprises 0.005-0.5 parts of jasmine flower extract; And / or, the composition further comprises 0.1-3 parts of peppermint extract; And / or, the composition further comprises 0-0.1 parts of artificial bezoar.

3. The composition according to claim 1 or 2, characterized in that According to the weight of the composition, the composition comprises:

4. Use of the composition according to any one of claims 1 to 3 in the preparation of an oral care product having mucosal repair, anti-inflammatory, and / or detumescent effects.

5. An oral care product with mucosal repair function, characterized in that: The product comprises the composition according to any one of claims 1 to 3 and auxiliary materials.

6. The product according to claim 5, characterized in that The products include toothpaste, mouthwash, oral spray, and oral patches.

7. The product according to claim 5 or 6, characterized in that The auxiliary materials include moisturizing agents, preservatives, foaming agents, thickeners, friction agents, flavoring agents, sweeteners, cooling agents, appearance improvers, and cleaning aids.

8. The product according to claim 7, characterized in that The product is toothpaste; Preferably, the moisturizing agent is selected from one or more of sorbitol, glycerin, polyethylene glycol-400, propylene glycol and polypropylene glycol; The preservative is selected from one or more of paraben, sodium benzoate, sorbic acid and DMDMH; The foaming agent is selected from one or more of cocamidopropyl betaine, sodium methyl cocoyl taurate, lauryl glucoside, glycolipids and lauric acid; The thickener is selected from one or more of cellulose gum, xanthan gum, carrageenan and hydroxyethyl cellulose; The friction agent is selected from one or more of calcium carbonate, calcium bicarbonate, calcium pyrophosphate, sodium metaphosphate and hydrated silica; The flavoring agent is selected from one or more of edible flavors, spearmint flavors, fruit flavors and cardamom flavors; The sweetener is selected from one or more of saccharin sodium, xylitol and erythritol; The cooling agent is selected from one or more of menthol, menthol, WS-10 and wintergreen mint essence; The appearance improver is selected from one or more of synthetic fluorphlogopite, mica, CI 77891, CI 19140, CI 74160 and CI 16255; The cleaning aid is selected from sodium chloride.

9. The product according to claim 8, characterized in that Based on 100 parts, the product includes the following components in parts by weight:

10. The product according to claim 9, characterized in that Based on 100 parts, the product includes the following components in parts by weight:

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