Biopsy specimen collecting device for digestive endoscopy

By designing a biopsy specimen collection device for digestive endoscopy and adjusting the immersion depth of the sample placement tube, the problem of tissue damage when removing specimens from the fixative was solved, and stable and efficient specimen removal was achieved.

CN120651579AInactive Publication Date: 2025-09-16QIANXINAN BUYEI & MIAO AUTONOMOUS PREFECTURE PEOPLES HOSPITAL
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Patent Information

Application Number
CN202510990825.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-18
Publication Date
2025-09-16
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

In the prior art, when biopsy specimens for digestive endoscopy are removed from the fixative, tissue damage is easily caused by multiple clamping. In addition, the surface tension and viscosity of the fixative increase the difficulty of clamping and the risk of tissue damage.

Method used

A biopsy specimen collection device for digestive endoscopy is designed, which includes a housing, a fixative storage tube, and a sample placement tube. The immersion depth of the sample placement tube can be adjusted by a height adjustment component to reduce the effects of liquid surface tension and viscosity on clamping and lower the risk of tissue damage.

Benefits of technology

It effectively reduces the difficulty of clamping and fixing specimens, reduces tissue damage, and improves the stability and safety of the specimen removal process.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention provides a digestive endoscopy biopsy specimen collecting device which comprises a machine shell, a sample containing cylinder, stationary liquid storage tubes and a height adjusting assembly, a plurality of through holes are formed in the top of the machine shell in the vertical direction, and the stationary liquid storage tubes are arranged in the through holes in a penetrating mode; the sample placing cylinders are arranged in the stationary liquid storage pipes, the tops of the sample placing cylinders are open, the bottoms of the sample placing cylinders are sealed, a plurality of liquid inlet holes are formed in the side walls of the sample placing cylinders, the top walls of the sample placing cylinders are connected with fixing parts, and the fixing parts are in sliding connection with the inner wall of the machine shell in the vertical direction; the height adjusting assembly is connected with the fixing part and used for enabling the fixing part to slide upwards or downwards by changing the height of the height adjusting assembly, and then the immersion depth of the sample containing barrel in the stationary liquid storage pipe is changed. According to the invention, the fixed specimen can be conveniently taken out, and the problem of tissue damage caused by repeatedly clamping the fixed specimen is avoided.
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Description

Technical Field

[0001] The invention relates to the technical field of digestive endoscopy equipment, in particular to a digestive endoscopy biopsy specimen collection device. Background Art

[0002] A digestive endoscopy biopsy specimen is a tissue sample removed from a diseased area of ​​the digestive tract during an endoscopic examination. These samples are typically small pieces of tissue that can be used for pathological analysis to assess tissue health, diagnose disease, or determine the nature of the lesion. Biopsy specimens can originate from the esophagus, stomach, small intestine, colon, and other areas and are typically used to detect cancer, inflammation, or other abnormalities.

[0003] The sample removed cannot be used directly as a biopsy specimen for examination. The sample needs to be placed in 10% neutral buffered formalin (NBF) fixative for fixation. After the fixed tissue is removed, it is dehydrated using a gradient of alcohol of different concentrations. The dehydrated tissue is treated with xylene or other transparent reagents to make it transparent for subsequent embedding. After embedding, the tissue is sliced, adhered, stained, and sealed to prepare a specimen that can be used for observation. In the above series of treatments, sample fixation is particularly important because fixing the tissue with the fixative can prevent tissue degradation and maintain the morphology of cells and tissues. This is the key to ensuring the accuracy of subsequent observation results.

[0004] Because the biopsy specimen preparation process is cumbersome, it's difficult to prepare individual specimens individually. Instead, multiple specimens collected during the same time period are pooled together for preparation. Different specimen types and sizes require different fixation times. The fixative is 10% neutral buffered formalin (NBF), which contains volatile formaldehyde. Placing all specimens in a single container reduces the formaldehyde concentration in the NBF, impacting sample processing efficiency. Therefore, currently, most specimens are processed using a single container of fixative per specimen. Typically, multiple test tubes containing fixative are individually sealed and held in a sealed container. However, because the test tubes are slender and small in diameter, and the fixed tissue is deep within the tubes, removing it from the tubes with tweezers after a certain fixation period for subsequent dehydration often requires multiple attempts to remove it, potentially leading to tissue damage. Therefore, designing a biopsy specimen collection device for digestive endoscopy that facilitates tissue removal from the fixative is crucial. Summary of the Invention

[0005] In view of the shortcomings of the existing technology, the purpose of the present invention is to provide a digestive endoscopy biopsy specimen collection device, which is convenient for removing fixed specimens and avoids the occurrence of tissue damage caused by repeated clamping of fixed specimens.

[0006] In order to solve the above technical problems, the present invention provides a digestive endoscopy biopsy specimen collection device, which includes:

[0007] The casing has an open top and a horizontal plate inside, and a plurality of through slots are vertically opened on the upper edge of the horizontal plate;

[0008] The fixing liquid storage tube is arranged longitudinally through each through groove;

[0009] A sample placement cylinder is disposed in each fixative storage tube, with the top of the sample placement cylinder being open and the bottom of the sample placement cylinder being sealed. The side wall of the sample placement cylinder is provided with a plurality of liquid inlet holes, and the top wall of the sample placement cylinder is connected to a fixing member, which is vertically slidably connected to the inner wall of the housing;

[0010] The height adjustment component is connected to the fixing piece and is used to change the height of the height adjustment component so that the fixing piece slides upward or downward, thereby changing the immersion depth of the sample placement cylinder in the fixing liquid storage tube.

[0011] Preferably, a supporting plate is provided in the horizontal direction inside the sample placement tube, and the supporting plate is connected to the sample placement tube in a vertical sliding manner. A plurality of first through holes are provided on the supporting plate, and a limit block is provided on the inner wall of the sample placement tube above the supporting plate. The bottom of the supporting plate is connected to the bottom wall of the sample placement tube through a plurality of springs.

[0012] Preferably, a plurality of drainage holes are provided on the bottom wall of the sample placement tube, and a one-way valve is provided in each of the plurality of liquid inlet holes and the plurality of liquid drainage holes. The one-way valves in the plurality of liquid inlet holes are used to limit the fixative liquid from entering the fixative liquid storage tube into the sample placement tube, and the one-way valves in the plurality of liquid drainage holes are used to limit the fixative liquid from entering the fixative liquid storage tube from the sample placement tube.

[0013] Preferably, the spring outer sleeve is provided with a guide cylinder, the top end of the guide cylinder is connected to the bottom wall of the sample placement cylinder, and the bottom end of the guide cylinder is connected to the bottom wall of the fixative storage tube.

[0014] Preferably, an elastic membrane is provided in the sample placement tube in a horizontal direction for sealing, and a plurality of second through holes are provided on the elastic membrane.

[0015] Preferably, a guide plate is obliquely provided on the sample placement tube.

[0016] Preferably, the diameter of the drainage hole gradually increases from top to bottom.

[0017] Preferably, the housing is provided with a sealing cover, which is buckled with the top of the housing, and each of the fixative storage tubes is provided with a matching sealing plug, and the height of the sample placement tube is less than one-third of the height of the fixative storage tube.

[0018] Preferably, the fixing liquid storage tube is clamped in each through groove, and the bottom of the fixing liquid storage tube is also clamped with the bottom wall of the casing.

[0019] Preferably, the side wall of the housing is provided with a plurality of slots in the vertical direction, and the distances from the plurality of fixing liquid storage tubes to the center of the housing are equal, and the height adjustment assembly comprises:

[0020] A first rack is vertically arranged on the casing and is slidably connected to the inner wall of the casing;

[0021] A pressing plate extends through the slots in a horizontal direction and is connected to the first rack;

[0022] a gear, rotatably connected to the housing, the gear meshing with the first rack;

[0023] The second rack is vertically arranged on the fixing liquid storage tube and is slidably connected to the wall of the fixing liquid storage tube. The second rack is meshed with the gear, and the top of the second rack is connected to the fixing piece.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] The present invention causes the height adjustment component to extend, and the height adjustment component drives the fixing part to slide upward along the inner wall of the casing, so that the sample placement tube gradually moves toward the tube mouth of the fixative storage tube. Since the liquid height of the fixative is two-thirds of the height of the fixative storage tube, the depth of the sample placement tube immersed in the fixative storage tube after rising is reduced, thereby reducing the problem of increased adhesion between the specimen and the tweezers caused by the surface tension and viscosity of the fixative liquid, reducing the difficulty of clamping. In addition, the depth of the tweezers inserted into the liquid is reduced, and the hidden danger of liquid movement affecting the stability of the specimen is reduced. Therefore, when the tweezers are used to clamp the fixed tissue, it is easy to clamp it out and it is not easy to cause tissue damage. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is a schematic diagram of the overall structure of a digestive endoscopy biopsy specimen collection device of the present invention. Figure 1 .

[0027] Figure 2 This is a schematic diagram of the overall structure of a digestive endoscopy biopsy specimen collection device of the present invention. Figure 2 .

[0028] Figure 3 This is a schematic diagram of the overall structure of a digestive endoscopy biopsy specimen collection device of the present invention. Figure 3 .

[0029] Figure 4This is a schematic diagram of the overall structure of a digestive endoscopy biopsy specimen collection device of the present invention. Figure 4 ;

[0030] Figure 5 This is a schematic diagram of the overall structure of a digestive endoscopy biopsy specimen collection device of the present invention. Figure 5 ;

[0031] Figure 6 This is a schematic diagram of the overall structure of a digestive endoscopy biopsy specimen collection device of the present invention. Figure 6 .

[0032] Description of reference numerals:

[0033] 1. Casing, 2. Fixative storage tube, 3. Sample placement tube, 4. Liquid inlet, 5. Fixing part, 6. Height adjustment assembly, 6-1. First rack, 6-2. Pressing plate, 6-3. Gear, 6-4. Second rack, 7. Loading plate, 8. Limit block, 9. Spring, 10. Drain hole, 11. Guide tube, 12. Elastic membrane, 13. Guide plate, 14. Slot. DETAILED DESCRIPTION

[0034] In order to make the above-mentioned purposes, features and advantages of the embodiments of the present invention more obvious and easy to understand, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts shall fall within the scope of protection of the present invention.

[0035] The inventors found that because the test tube is slender and small in diameter, and the fixed tissue is at the bottom of the test tube, when it is fixed for a certain period of time and then removed from the test tube with tweezers for subsequent dehydration, it often takes multiple clamping operations to remove it, which may cause tissue damage. This is because the fixation process usually causes the cells and fibers in the tissue to cross-link. Although it enhances the overall stability, it may also cause the connection between cells to become fragile. When using tweezers to reach into the test tube to clamp and fix the specimen, the mechanical stress on the tissue may increase due to improper operation angle of the tweezers. In addition, the inventors also found that the liquid in the test tube will interfere with the clamping of the fixed specimen. The surface tension and viscosity of the liquid may increase the adhesion between the specimen and the tweezers, making clamping difficult. In addition, the movement of the liquid may also affect the stability of the specimen and increase the risk of damage. Therefore, try to avoid clamping directly in the liquid, or gently shake it when clamping to reduce liquid interference. Only in this way can the fixed tissue be less likely to be damaged during clamping.

[0036] In view of this, the present invention provides a digestive endoscopy biopsy specimen collection device, which facilitates the removal of fixed specimens and avoids the occurrence of tissue damage caused by repeated clamping of fixed specimens.

[0037] like Figures 1 to 6 As shown, the present invention provides a digestive endoscopy biopsy specimen collection device, which includes: a housing 1, a fixative storage tube 2, a sample placement tube 3 and a height adjustment component 6, wherein:

[0038] The top of the housing 1 is open, and a horizontal plate is provided inside the housing 1, and a plurality of through slots are vertically provided on the upper edge of the horizontal plate;

[0039] The fixing liquid storage tube 2 is disposed longitudinally through each through groove. Here, the fixing liquid storage tube 2 can be fixedly connected to the inner wall of the through hole, or can be detachably connected to the inner wall of the through hole. The detachable connection method can be a snap connection or a threaded connection. Any structure that can prevent the fixing liquid storage tube 2 from tilting is acceptable.

[0040] A sample placement tube 3 is disposed within each fixative storage tube 2, and the top of the sample placement tube 3 is open, while the bottom of the sample placement tube 3 is sealed. A plurality of liquid inlet holes 4 are provided on the side walls of the sample placement tube 3. The fixative in the fixative storage tube 2 will enter the sample placement tube 3 through the plurality of liquid inlet holes 4, thereby increasing the weight of the sample placement tube 3 and enabling the sample placement tube 3 to be quickly immersed in the fixative in the fixative storage tube 2. A fixing member 5 is connected to the top wall of the sample placement tube 3, and the fixing member 5 is vertically slidably connected to the inner wall of the housing 1. The fixing member 5 here is an L-shaped fixing plate, and the vertical end of the L-shaped fixing plate is connected to the top wall of the sample placement tube 3, while the horizontal end of the L-shaped fixing plate is vertically slidably connected to the inner wall of the housing 1.

[0041] The height adjustment component 6 is connected to the fixing part 5, and is used to change the height of the height adjustment component 6 so that the fixing part 5 slides upward or downward, thereby changing the immersion depth of the sample placement tube 3 in the fixative storage tube 2. The height adjustment component 6 given here can be an electric push rod, a screw rod, or any other structural component that can change the height.

[0042] During use, by extending the height of the height adjustment component 6, the height adjustment component 6 will drive the fixing part 5 to slide upward along the inner wall of the casing 1, so that the sample placement tube 3 gradually moves toward the tube mouth of the fixative liquid storage tube 2. Since the liquid height of the fixative is two-thirds of the height of the fixative liquid storage tube 2, the depth of the sample placement tube 3 immersed in the fixative liquid storage tube 2 after rising will be reduced, thereby reducing the problem of increased adhesion between the specimen and the tweezers caused by the surface tension and viscosity of the fixative liquid, reducing the difficulty of clamping. In addition, the depth of the tweezers inserted into the liquid is reduced, and the hidden danger of liquid movement affecting the stability of the specimen is reduced. Therefore, when using tweezers to clamp the fixed tissue, it is easy to clamp it out and it is not easy to cause tissue damage.

[0043] Specifically, in order to minimize the depth of the sample immersed in the fixative during sampling, a supporting plate 7 is provided in the horizontal direction inside the sample placement tube 3. The supporting plate 7 is connected to the sample placement tube 3 in a vertical sliding manner. A plurality of first through holes are provided on the supporting plate 7. A limit block 8 is provided on the inner wall of the sample placement tube 3 above the supporting plate 7. The bottom of the supporting plate 7 is connected to the bottom wall of the sample placement tube 3 through a plurality of springs 9.

[0044] When in use, the sample is placed on the carrier plate 7, and the fixative in the fixative storage tube 2 enters the sample placement cylinder 3 through the multiple liquid inlet holes 4, thereby increasing the weight of the sample placement cylinder 3, enabling the sample placement cylinder 3 to be quickly immersed in the fixative in the fixative storage tube 2, and the fixative entering the sample placement cylinder 3 is also sent into the fixative storage tube 2 located below the carrier plate 7 through the multiple first through holes. At this time, the carrier plate 7 is not only subject to buoyancy but also to the weight of the sample and the weight of the liquid immersed in the fixative. The buoyancy is less than the weight of the sample and the weight of the liquid immersed in the fixative, so the carrier plate 7 is not subject to buoyancy. The plate 7 will move downward, and at the same time, the multiple springs 9 below the supporting plate 7 will be compressed. When the height of the height adjustment component 6 is extended, the height adjustment component 6 will drive the fixing member 5 to slide upward along the inner wall of the housing 1, thereby causing the sample placement tube 3 to gradually move toward the nozzle of the fixative storage tube 2. Since the liquid height of the fixative is two-thirds of the height of the fixative storage tube 2, the depth of the sample placement tube 3 immersed in the fixative storage tube 2 will decrease after the rise. At this time, the multiple springs 9 at the bottom of the supporting plate 7 will recover their deformation, and then the height of the supporting plate 7 will increase, thereby reducing the liquid level height immersed in the fixative. The problem of increased adhesion between the specimen and the tweezers caused by the surface tension and viscosity of the fixative liquid is reduced, and the difficulty of clamping is reduced. In addition, the depth of the tweezers inserted into the liquid is reduced, and the hidden danger of the liquid movement affecting the stability of the specimen is reduced. Therefore, when using the tweezers to clamp the fixed tissue, it is easy to clamp it out and it is not easy to cause tissue damage.

[0045] Specifically, a plurality of drainage holes 10 are provided on the bottom wall of the sample placement tube 3, and a one-way valve is provided in each of the plurality of liquid inlet holes 4 and the plurality of drainage holes 10. The one-way valve in the plurality of liquid inlet holes 4 is used to limit the fixing liquid from entering the fixing liquid storage tube 2 into the sample placement tube 3, and the one-way valve in the plurality of drainage holes 10 is used to limit the fixing liquid from entering the fixing liquid storage tube 2 from the sample placement tube 3.

[0046] In order to increase the deformation force of the multiple springs 9, the supporting plate 7 can be brought as close to the bottom wall of the sample placement tube 3 as possible during use. Therefore, the fixative entering the sample placement tube 3 through the through hole and the liquid inlet hole will squeeze the supporting plate 7 downward, and part of the fixative will be discharged from the multiple drainage holes 10 when the supporting plate 7 moves downward. When the height of the height adjustment component 6 is extended, the height adjustment component 6 will drive the fixing part 5 to slide upward along the inner wall of the casing 1, so that the sample placement tube 3 gradually moves toward the tube mouth of the fixative storage tube 2. Since the liquid height of the fixative is two-thirds of the height of the fixative storage tube 2, the depth of immersion of the sample placement tube 3 in the fixative storage tube 2 after rising will be reduced. At this time, the multiple springs 9 at the bottom of the supporting plate 7 will restore their deformation. Due to the large deformation force, they can be as far away from the liquid surface of the fixative as possible, reducing the problem of increased adhesion between the specimen and the tweezers caused by the surface tension and viscosity of the fixative, thereby reducing the difficulty of clamping.

[0047] Specifically, a guide cylinder 11 is provided on the outer sleeve of the spring 9, the top end of the guide cylinder 11 is connected to the bottom wall of the sample placement cylinder 3, and the bottom end of the guide cylinder 11 is connected to the bottom wall of the fixative storage tube 2, for ensuring that the spring 9 moves vertically.

[0048] Specifically, in order to minimize the depth of the sample immersed in the fixative during sampling, a structure that can quickly lift the fixed sample is provided herein. An elastic membrane 12 is sealed in the horizontal direction inside the sample placement tube 3, and a plurality of second through holes are provided on the elastic membrane 12.

[0049] The elastic deformation of the elastic membrane 12 is used to ensure whether the sample is immersed below the liquid surface of the fixative or away from the fixative.

[0050] When in use, the upper surface of the elastic membrane 12 is affected by the gravity of the sample and the gravity of the fixative liquid, while the lower surface of the elastic membrane 12 is affected by the buoyancy of the fixative liquid. The force acting on the upper surface of the elastic membrane 12 is greater than the force acting on the lower surface of the elastic membrane 12, so the elastic membrane 12 bends downward and deforms. When the height adjustment component 6 drives the fixing part 5 to slide upward along the inner wall of the casing 1, the sample placement tube 3 gradually moves toward the tube mouth of the fixative storage tube 2. Since the liquid height of the fixative is two-thirds of the height of the fixative storage tube 2, the depth of the sample placement tube 3 immersed in the fixative storage tube 2 after rising will be reduced. At this time, the elastic membrane 12 will restore its deformation, which will reduce the problem of increased adhesion between the specimen and the tweezers caused by the surface tension and viscosity of the fixative liquid, thereby reducing the difficulty of clamping.

[0051] Specifically, the sample placement tube 3 is provided with an inclined guide plate 13, which can quickly gather the liquid to the drainage hole 10, so that the drainage hole 10 quickly discharges the fixing liquid, thereby allowing the elastic membrane 12 or the spring 9 to quickly recover its deformation.

[0052] Specifically, the diameter of the drainage holes 10 gradually increases from top to bottom, reducing the drainage rate. This design causes the fluid to gradually diffuse during discharge, reducing the flow rate and potentially increasing pressure recovery, thereby reducing the overall flow rate. This prevents vibration of the elastic membrane or support plate caused by the rapid recovery of elastic forces due to excessive flow, thereby protecting the fixed specimen.

[0053] Specifically, the housing 1 is provided with a sealing cover, which is buckled with the top of the housing 1 , and each of the fixative storage tubes 2 is provided with a matching sealing plug, and the height of the sample placement tube 3 is less than one-third of the height of the fixative storage tube 2 .

[0054] Since the liquid height of the fixative is two-thirds of the height of the fixative storage tube, when the height of the sample placement tube needs to be less than one-third of the height of the fixative storage tube, the raised sample placement tube will be located above the liquid surface of the fixative, thereby completely avoiding the problem of increased adhesion between the specimen and the tweezers caused by the surface tension and viscosity of the fixative, and completely avoiding the problem that liquid movement may also affect the stability of the specimen.

[0055] Specifically, the fixing liquid storage tube 2 is clamped in each through groove, and the bottom of the fixing liquid storage tube 2 is also clamped with the bottom wall of the casing 1 to ensure that the fixing liquid storage tube 2 is easy to take out and replace the fixing liquid.

[0056] Specifically, in order to reduce costs, improve convenience, and reduce dependence on electricity, the side wall of the housing 1 is vertically provided with a plurality of slots 14, and the distances from the plurality of fixing liquid storage tubes 2 to the center of the housing 1 are equal in length. The height adjustment assembly 6 includes:

[0057] The first rack 6-1 is vertically arranged on the housing 1 and is slidably connected to the inner wall of the housing 1;

[0058] The pressing plate 6-2 passes through the slots 14 in the horizontal direction and is connected to the first rack 6-1;

[0059] Gear 6-3 is rotatably connected to the housing 1, and the gear 6-3 is meshed with the first rack 6-1;

[0060] The second rack 6-2 is vertically arranged on the fixed liquid storage tube 2 and is slidingly connected to the wall of the fixed liquid storage tube 2. The second rack 6-2 is meshed with the gear 6-3, and the top of the second rack 6-2 is connected to the fixing member 5.

[0061] Obviously, those skilled in the art may make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims and their equivalents, the present invention is intended to include such modifications and variations.

Claims

1. A digestive endoscopy biopsy specimen collection device, characterized in that: The collecting device comprises: The housing (1) has an open top and is provided with a horizontal plate inside, and a plurality of through slots are vertically formed on the upper edge of the horizontal plate; A fixing liquid storage tube (2) is provided in each through groove along the longitudinal direction; A sample placement tube (3) is provided in each fixing liquid storage tube (2), and the top of the sample placement tube (3) is open, the bottom of the sample placement tube (3) is sealed, a plurality of liquid inlet holes (4) are provided on the side wall of the sample placement tube (3), and a fixing member (5) is connected to the top wall of the sample placement tube (3), and the fixing member (5) is vertically slidably connected to the inner wall of the housing (1); The height adjustment component (6) is connected to the fixing component (5) and is used to change the height of the height adjustment component (6) so as to make the fixing component (5) slide upward or downward, thereby changing the immersion depth of the sample placement cylinder (3) in the fixing liquid storage tube (2).

2. A digestive endoscopy biopsy specimen collection device according to claim 1, characterized in that: A supporting plate (7) is provided in the sample placement tube (3) along the horizontal direction. The supporting plate (7) is connected to the sample placement tube (3) in a vertical sliding manner. A plurality of first through holes are provided on the supporting plate (7). A limiting block (8) is provided on the inner wall of the sample placement tube (3) above the supporting plate (7). The bottom of the supporting plate (7) is connected to the bottom wall of the sample placement tube (3) via a plurality of springs (9).

3. A digestive endoscopy biopsy specimen collection device according to claim 2, characterized in that: A plurality of drainage holes (10) are provided on the bottom wall of the sample placement tube (3), and a plurality of the liquid inlet holes (4) and the plurality of the drainage holes (10) are both provided with one-way valves. The one-way valves in the plurality of the liquid inlet holes (4) are used to restrict the fixative liquid from entering the fixative liquid storage tube (2) into the sample placement tube (3), and the one-way valves in the plurality of the drainage holes (10) are used to restrict the fixative liquid from entering the fixative liquid storage tube (2) from the sample placement tube (3).

4. A digestive endoscopy biopsy specimen collection device according to claim 2, characterized in that: The outer sleeve of the spring (9) is provided with a guide cylinder (11), the top end of the guide cylinder (11) is connected to the bottom wall of the sample placement cylinder (3), and the bottom end of the guide cylinder (11) is connected to the bottom wall of the fixative storage tube (2).

5. A digestive endoscopy biopsy specimen collection device according to claim 1 or 3, characterized in that: An elastic membrane (12) is provided in a horizontally sealed manner inside the sample placement tube (3), and a plurality of second through holes are provided on the elastic membrane (12).

6. The digestive endoscopy biopsy specimen collection device according to claim 1, characterized in that: A guide plate (13) is obliquely provided on the sample placement tube (3).

7. The digestive endoscopy biopsy specimen collection device according to claim 3, characterized in that: The diameter of the drainage hole (10) gradually increases from top to bottom.

8. The digestive endoscopy biopsy specimen collection device according to claim 1, characterized in that: The housing (1) is provided with a sealing cover, which is buckled with the top of the housing (1). Each of the fixative storage tubes (2) is provided with a sealing plug that matches it. The height of the sample placement cylinder (3) is less than one-third of the height of the fixative storage tube (2).

9. The digestive endoscopy biopsy specimen collection device according to claim 1, characterized in that: The fixing liquid storage tube (2) is clamped in each through groove, and the bottom of the fixing liquid storage tube (2) is also clamped with the bottom wall of the casing (1).

10. The digestive endoscopy biopsy specimen collection device according to claim 1, characterized in that: The side wall of the housing (1) is provided with a plurality of slots (14) in the vertical direction, and the distances between the plurality of fixing liquid storage tubes (2) and the center of the housing (1) are equal in length. The height adjustment component (6) comprises: A first rack (6-1) is vertically arranged on the housing (1) and is slidably connected to the inner wall of the housing (1); A pressing plate (6-2) passes through each slot (14) in a horizontal direction and is connected to the first rack (6-1); A gear (6-3) is rotatably connected to the housing (1), and the gear (6-3) is meshed with the first rack (6-1); The second rack (6-2) is vertically arranged on the fixed liquid storage tube (2) and is slidably connected to the wall of the fixed liquid storage tube (2). The second rack (6-2) is meshed with the gear (6-3), and the top of the second rack (6-2) is connected to the fixing member (5).