Crawling pest control method

Abstract

The present invention relates to a method for controlling creeping pests, in which a control composition containing a pyrethroid compound volatilizes, characterized in that the control composition volatilizes into a space, thereby controlling the creeping pests. The concentration of the pyrethroid compound in the gas in the space is maintained within the range of 1 [mu] g / m3 to 100 [mu] g / m3, and creeping pests are prevented from staying in the space.

Description

Technical Field

[0001] The present invention relates to a method for controlling creeping pests. Background Art

[0002] Conventionally, various preparations such as aerosols, fumigants, and poison baits have been used to control creeping pests such as cockroaches.

[0003] For example, aerosols are widely used that repel creeping pests by directly spraying an active ingredient onto them.

[0004] Fumigants are also known as preparations that repel crawling pests by causing active ingredients diffused in a space by heating to come into contact with the crawling pests or by causing the crawling pests to inhale the active ingredients.

[0005] However, these preparations may cause crawling insect carcasses to enter the user's field of vision during repelling, causing discomfort. Furthermore, repelling insects using aerosols or fumigants can sometimes cause the active ingredients in the insects to excite the nerves, causing them to move about or flash out (flying out from hiding), causing discomfort to the user. Furthermore, because fumigants diffuse their active ingredients into indoor spaces, users must exit the space during handling, and fire alarms, etc., must be covered. Excessive use of these preparations to repel crawling insects can also contribute to the development of insecticide resistance.

[0006] In response to this, research is underway to develop cockroach repellents for repelling cockroaches, a type of creeping pest. For example, Patent Document 1 discloses a cockroach repellent comprising an extract obtained by soaking at least one plant piece selected from the group consisting of dill, celery, caraway, cumin, cinnamon, nutmeg, and chili pepper in a solvent.

[0007] Prior art literature

[0008] Patent Literature

[0009] Patent Document 1: Japanese Patent Application Laid-Open No. 2006-056867 Summary of the Invention

[0010] Problems to be solved by the invention

[0011] The cockroach repellent described in Patent Document 1 is applied by spreading or coating it in drawers, cabinets, and other areas in the kitchen where cockroaches are present. Thus, conventional repellents are often applied directly in relatively narrow, enclosed spaces where no one enters or exits. There are few methods for achieving long-term, stable control of crawling pests in large, human-accessible spaces such as entire indoor spaces.

[0012] Therefore, an object of the present invention is to provide a method for controlling crawling pests that can stably provide a comfortable space without crawling pests for a long time without causing the crawling pests to become nervous or leaving their bodies in the space.

[0013] In addition, the present invention also aims to provide a method for suppressing the activities of crawling pests in a space.

[0014] Means for solving problems

[0015] The present inventors have conducted extensive research to address the above-mentioned issues and have discovered that, if creeping insects are lurking and breeding within a space or invading from outside, migrating them from within the space to the outside can prevent them from settling in the space, thereby creating a comfortable space. Further research has revealed that by using a specific active ingredient and maintaining the concentration of the active ingredient in the air within the space within a certain range, these creeping insects can be prevented from settling in the space, thus completing the present invention.

[0016] That is, the present invention relates to the following [1] and [2].

[0017] [1] A method for controlling creeping pests, wherein a control composition containing a pyrethroid compound is volatilized, characterized in that:

[0018] By volatilizing the control composition into the space, the concentration of the pyrethroid compound in the air in the space is maintained at 1 μg / m 3 ~100 μg / m 3 within the scope of the above space to prevent creeping pests from settling in it.

[0019] [2] A method for controlling creeping pests, comprising heating and evaporating a control composition containing a pyrethroid compound, wherein:

[0020] By heating and evaporating the control composition into the space, the concentration of the pyrethroid compound in the gas in the space is maintained at 1 μg / m 3 ~100 μg / m 3 within the scope of the above space to prevent creeping pests from settling in it.

[0021] Effects of the Invention

[0022] The crawling insect control method of the present invention can prevent crawling insects from settling in a room, thereby providing a comfortable and stable space for a long period of time without causing the crawling insects to become nervous or leaving their bodies in the room. Furthermore, even if crawling insects invade the room from outside, the crawling insects can be urged to move back out, preventing them from settling in the room.

[0023] Furthermore, by applying the control composition in the crawling pest control method of the present invention to a closed space, the activities of the crawling pests in the closed space can also be suppressed. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a schematic diagram for explaining the test method for preventing creeping insects from settling.

[0025] Figure 2 This is a schematic diagram for explaining the test method for the activity inhibition effect, feeding inhibition effect, and proliferation inhibition effect on cockroaches.

[0026] Figure 3 It is a graph showing the temporal changes in the number of survival cells in the proliferation inhibition evaluation.

[0027] Figure 4 It is a graph showing the temporal change of the egg fertilization rate in the growth inhibition evaluation.

[0028] Figure 5 It is a graph showing the temporal change in the number of eggs laid in the growth inhibition evaluation. DETAILED DESCRIPTION

[0029] <Crawling Pest Control Methods>

[0030] The creeping insect control method of this embodiment (hereinafter sometimes referred to as "control method") volatilizes a control composition containing a pyrethroid compound. By volatilizing the control composition into the air, the concentration of the pyrethroid compound in the air in the air is maintained at 1 μg / m 3 ~100 μg / m 3 Thus, crawling pests can be prevented from settling in the space, and the crawling pests can be prevented and controlled.

[0031] The control method of this embodiment can prevent creeping pests from settling in a space. Preventing creeping pests from settling in a space means, unlike repelling pests that inhibit their intrusion into a space, that creeping pests are encouraged to move outward even if they are lurking and breeding in the space or have invaded from outside.

[0032] In the control method of this embodiment, a pyrethroid compound is used as an active ingredient and the concentration of the pyrethroid compound in the air in the space is maintained at 1 μg / m 3 ~100 μg / m 3 Within the range of , the above-mentioned stopping prevention effect can be achieved.

[0033] The concentration of the pyrethroid compound in the air can be adjusted by the material and size of the carrier such as the wick or pad described below, the heating temperature, the composition of the control composition, the concentration of the pyrethroid compound as the active ingredient in the control composition, etc.

[0034] By maintaining the concentration of pyrethroid compounds in the air at 1μg / m 3 The above concentration in the gas is preferably 1.5 μg / m 3 More preferably, 3 μg / m 3 above.

[0035] On the other hand, from the perspective of safety to the human body and prevention of the death or knockdown of creeping pests that may cause discomfort to the user, and the prevention of flashbacks due to nervous excitement, the concentration of pyrethroid compounds in the air is set to 100 μg / m 3 Below, preferably 90 μg / m 3 Below, more preferably 80 μg / m 3 the following.

[0036] The concentration of the aforementioned gases is preferably constant throughout the space where the control composition is volatilized. This prevents creeping pests from locating the space itself, regardless of their location within the space, further enhancing their deterrent effect. The volatilization method, temperature, duration, composition, and concentration of the control composition can be appropriately adjusted based on the size of the space.

[0037] It should be noted that the concentration of gas in the entire space must be within ±10 μg / m when measuring the concentration of gas at any height between 10 cm and 150 cm in the space. 3 the following.

[0038] For volatilization of the control composition into a space, examples include natural evaporators, fan-type formulations, piezoelectric automatic spray formulations, and heated evaporators. Of these, natural evaporators, fan-type formulations, and heated evaporators are preferred from the perspective of maintaining a constant concentration of the pyrethroid compound in the gas throughout the space, regardless of the volatility of the volatilized pyrethroid compound contained in the control composition. Heated evaporators are more preferred from the perspective of further minimizing the impact of the environment in the space where the control composition is volatilized. It should be noted that the aforementioned environment refers to temperature, ventilation conditions, the presence and intensity of wind flow, and the like.

[0039] That is, the creeping pest control method of the present embodiment is more preferably to maintain the gaseous concentration of the pyrethroid compound in the space within a predetermined range by heating and evaporating the control composition into the space.

[0040] A natural evaporating agent refers to a substance that allows the control composition to evaporate naturally by being carried on a carrier without the use of artificial means such as ventilation or heating. Examples of carriers include paper, thread (such as twisted yarn), non-woven fabrics, wood, pulp, inorganic polymers, inorganic porous materials (such as silicates, silica, and zeolites), organic polymers (such as cellulose, polyethylene, polypropylene, and polyvinyl alcohol), sublimable substances (such as adamantane, cyclododecane, paradichlorobenzene, naphthalene, and camphor), resin plates, evaporative sheets, and oil-absorbing polymers. Combinations of one or more of these may be used. The method of carrying the composition is not particularly limited, and examples include dropwise addition, impregnation, and kneading.

[0041] A fan-type formulation is a formulation in which the control composition is carried on a carrier and evaporated by the use of a fan. The carrier is used to impregnate and carry the liquid control composition and is made of a material that does not hinder the diffusion of the control composition. Examples of carriers include porous materials with air permeability such as organic polymers, non-woven fabrics, cotton, sponges, and foams with interconnected cells. The method of carrying the composition is not particularly limited and examples include dropwise addition, impregnation, and mixing.

[0042] A piezoelectric automatic spray formulation is one in which a carrier attached to a bottle filled with a control composition contacts the back of a metal plate to supply the control composition. Ultrasonic vibrations of the piezoelectric element cause the control composition to evaporate. When using a wick as a carrier, a rod-shaped core material such as felt, sponge, cotton, or a porous material can be used.

[0043] The heating evaporative agent refers to a preparation that stably evaporates the control composition supported on a carrier by heating.

[0044] The heating temperature during heating and evaporation also varies depending on the type of pyrethroid compound used, but is preferably 120°C to 160°C, for example. To ensure sufficient evaporation of the pyrethroid compound, the heating temperature is preferably 120°C or higher, more preferably 125°C or higher, and even more preferably 130°C or higher. On the other hand, to prevent thermal decomposition of the pyrethroid compound, the heating temperature is preferably 160°C or lower, more preferably 155°C or lower, and even more preferably 150°C or lower. The heating temperature in this specification refers to the surface temperature of the heater in the heating evaporator, as measured by a temperature sensor (503E-TC1-ASP, manufactured by Anritsu Keiki Co., Ltd.).

[0045] In the control method of this embodiment, the concentration of the pyrethroid compound in the gas is maintained at 1 μg / m 3 ~100 μg / m 3 The time within the range of is, for example, preferably 2 to 24 hours per day, or 2 to 12 hours. Here, the above-mentioned maintenance time per day is preferably more than 2 hours, more preferably more than 4 hours, and even more preferably more than 6 hours. As mentioned above, by setting the maintenance time to be more than a certain value, it is possible to further promote the movement of crawling pests from the treated space treated with the control composition to the untreated untreated space, thereby obtaining a better stopping prevention effect. On the other hand, the above-mentioned maintenance time per day can be 24 hours, i.e., one day, but since a sufficient stopping prevention effect can be obtained by maintaining it for 12 hours per day, the maintenance time can be less than 12 hours.

[0046] The above-mentioned range of maintenance time may be satisfied by continuously volatilizing the control composition, or by intermittently volatilizing the control composition and satisfying the above-mentioned range of maintenance time by the combined effect of these.

[0047] In the control method of this embodiment, from the perspective of continuously preventing creeping pests from settling in a space, for example, when the above-mentioned maintenance period is set to 24 hours per day, it is preferably applied for one day or more, more preferably for three consecutive days or more, and particularly preferably for seven consecutive days or more. When the above-mentioned maintenance period is set to 12 hours per day, it is preferably applied for one day or more, more preferably for three consecutive days or more, and particularly preferably for seven consecutive days or more.

[0048] In the control method of this embodiment, the ventilation condition of the space where the control composition is volatilized is preferably 0.1 times / hour to 20 times / hour. Here, from the perspective of safety for the human body and the airtightness of the building, the ventilation condition of the above-mentioned space is preferably 0.1 times / hour or more, more preferably 0.2 times / hour or more, and even more preferably 0.3 times / hour or more. In addition, from the perspective of appropriately obtaining the effect of preventing crawling pests from settling in the space, the ventilation condition of the space is preferably 20 times / hour or less, more preferably 15 times / hour or less, and even more preferably 12 times / hour or less. It should be noted that the ventilation condition of the space in this specification is a technical term that indicates how many times the air in the space is replaced in 1 hour, and can be calculated by supplying carbon dioxide to the indoor space and measuring the decrease in its concentration caused by ventilation.

[0049] Specifically, the following description will be based on the test method of "Sanitary Testing Methods: Annotations 2000, edited by the Pharmaceutical Society of Japan, published in 2000."

[0050] Towards the measured indoor space (V R :Capacity of indoor space m 3 ) After supplying an appropriate amount of carbon dioxide, the air in the room is stirred to make the carbon dioxide concentration uniform, and the average concentration of carbon dioxide in the room is measured. Then, after a certain time t, the air is stirred again and the average concentration of carbon dioxide in the room is measured. t In addition, the carbon dioxide concentration C0 contained in the air entering from outside the indoor space is measured.

[0051] Ventilation volume V(m 3 / hour) or the ventilation condition E can be calculated by the following calculation formula.

[0052] [Calculation formula]

[0053] V=2.303×(V R ÷t)×log{(C1-C0)÷(C t -C0)}

[0054] E=V÷V R

[0055] The ventilation condition in this embodiment refers to the ventilation condition E calculated by the above-mentioned test method.

[0056] As long as the above-mentioned ventilation conditions are met, the prevention and control method of this embodiment can allow people to enter and exit the treatment space, windows or doors to be opened, air conditioning to be operated, etc. There are no special restrictions as long as the temperature or humidity of the treatment space is within the range assumed as the indoor environment of a home.

[0057] The control method of this embodiment can be applied to a certain size of space in a house or indoors. The volume of the space used is preferably 1m 3 ~93.3m 3 Here, the volume of the above space is preferably 1m 3 More than 15.6m 3 (Equivalent to 4 tatami: area 6.5m 2 × height 2.4m) or more, more preferably 23.3m 3 (Equivalent to 6 tatami: area 9.7m 2 In addition, from the viewpoint of maintaining a constant concentration of the pyrethroid compound in the gas in the space, the volume of the space used is preferably 93.3 m 3 (Equivalent to 24 tatami: area 38.9m 2 ×Height 2.4m or less).

[0058] The size of the space to be used is preferably 0.5 m or more on one side, more preferably 1.8 m or more, further preferably 2.5 m or more, and preferably 8 m or less. The height of the space to be used can be, for example, 1.8 m or more, 2 m or more, or 10 m or less, or 6 m or less.

[0059] Enclosed spaces such as closets and cabinets within the treatment area can be opened to prevent creeping pests from settling in. Similarly, bathrooms and toilets can be separated by doors that open to prevent creeping pests from settling in adjacent spaces.

[0060] Examples of creeping pests targeted by the control method of this embodiment include cockroaches, bedbugs, centipedes, millipedes, tumbleworms, ants, spiders, stink bugs, and mites. Of these, cockroaches, ants, centipedes, and mites are preferred, with cockroaches being more preferred. Examples of cockroaches include Periplaneta fuliginosa, German cockroaches, American cockroaches, Periplaneta japonica, and Periplaneta fusca. Examples of mites include house dust mites, Dermatophagoides farinae, Dermatophagoides farinae, Flour mites, and Carnivorous mites.

[0061] Examples of pyrethroid compounds include metofluthrin, transfluthrin, fenthrin, profluthrin, transfluthrin, prallethrin, allethrin, cyfluthrin, phenothrin, permethrin, fenvalerate, cypermethrin, pyrethrin, bifenthrin, cypermethrin, cyfluthrin, cypermethrin, and etofenprox. Among them, preferably, a compound having a vapor pressure of 1.0×10 -4Pyrethroid compounds volatile at room temperature of Pa or higher preferably include, for example, metofluthrin, transfluthrin, lindrin, profluthrin, transfluthrin, prallethrin, allethrin, and cypermethrin. From the perspective of diffusibility and more effective prevention of insect stagnation, metofluthrin and transfluthrin are even more preferably included. These pyrethroid compounds may be used alone or in combination of two or more.

[0062] The content of the pyrethroid compound in the control composition or the amount retained in the carrier is not particularly limited as long as the concentration of the pyrethroid compound in the air during volatilization can be maintained within the above range. For example, when the volatilization method is heating evaporation, it is preferably 0.2 w / v% to 16 w / v% (mass volume percentage). Here, it is easy to quickly adjust the concentration of the pyrethroid compound in the air during heating evaporation to 1 μg / m 3 From the above viewpoints, the above content is preferably 0.2 w / v% (mass volume percentage) or more, more preferably 0.4 w / v% or more, and even more preferably 0.8 w / v% or more. In addition, it is easy to adjust the concentration of the pyrethroid compound in the gas to 100 μg / m 3 From the viewpoints of preventing clogging of the liquid-absorbing wick and achieving excellent formulation stability, the content is preferably 16 w / v% or less, more preferably 14 w / v% or less, and even more preferably 12 w / v% or less.

[0063] In addition, when two or more pyrethroid compounds are contained, it is preferable that the total content thereof is within the above range.

[0064] When the volatilization method is a natural evaporation agent or a fan-type preparation, the above-mentioned content or retention amount is preferably, for example, 0.01 g / g to 1 g / g.

[0065] The particle size of the control composition is not particularly limited, as long as the concentration of the pyrethroid compound in the air during volatilization of the control composition is maintained within the above-mentioned range. For example, it may be 0.01 μm to 15 μm. From the perspective of improving diffusibility into air, the particle size is preferably 15 μm or less, more preferably 13 μm or less, and even more preferably 11 μm or less. The lower limit of the particle size is not particularly limited, but for example, it is 0.01 μm or greater.

[0066] In this specification, the particle size of the control composition refers to the mass median diameter of the control composition volatilized in the space. Specifically, the control composition can be volatilized in a closed 6-tatami space (area 9.7m) at about 25°C. 2The particles were volatilized in a room (height 2.4 m) and collected for 6 hours using a particle size analyzer (Andersen low-pressure cascade impactor) installed in the room. The mass distribution of each particle size was measured and the mass median diameter was calculated.

[0067] The control composition only needs to contain a pyrethroid compound, and other components are optional.

[0068] Other components include, in addition to the solvent, additives such as emulsifiers, binders, dispersants, stabilizers, volatility regulators, antioxidants, bactericides, mildew inhibitors, deodorants, fragrances, and colorants, and conventionally known additives may be used.

[0069] The solvent is not particularly limited, and examples thereof include: water; aliphatic hydrocarbons (paraffinic hydrocarbons and unsaturated aliphatic hydrocarbons) with a boiling point of 150°C to 350°C, such as hexane, kerosene, kerosene, normal paraffins, isoparaffins, and cycloparaffins; aromatic hydrocarbons such as benzene, toluene, and xylene; halogenated hydrocarbons such as dichloroethane and carbon tetrachloride; alcohols such as ethanol, isopropanol, ethylene glycol, and hexyl glycol; ketones such as acetone, methyl ethyl ketone, and cyclohexanone; ethers such as tetrahydrofuran, dimethoxyethane, and diethyl ether; esters such as ethyl acetate and hexyl laurate; nitriles such as acetonitrile; amides such as dimethylformamide, etc.

[0070] From the viewpoint of stably and continuously volatilizing the control composition for a long period of time, the solvent is preferably an aliphatic hydrocarbon (paraffinic hydrocarbons and unsaturated aliphatic hydrocarbons).

[0071] The emulsifier, binder, and dispersant are not particularly limited, and examples thereof include surfactants such as soaps, polyoxyethylene alkyl allyl ethers, polyoxyethylene fatty acid esters, glycerol fatty acid esters, sorbitan fatty acid esters, higher alcohol sulfates, and alkyl allyl sulfonates.

[0072] The stabilizer is not particularly limited, and examples thereof include butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), 3,5-di-tert-butyl-4-hydroxyanisole, mercaptobenzimidazole, dilaurylthiodipropionate, 2,2'-methylenebis-(6-tert-butyl-4-methylphenol), 2,2'-methylenebis-(6-tert-butyl-4-ethylphenol), 4,4'-methylenebis-(2,6-di-tert-butylphenol), 4,4'-butylenebis-(6-tert-butyl -3-methylphenol), 4,4'-thiobis-(6-tert-butyl-3-methylphenol), 1,1-bis-(4-hydroxyphenyl)cyclohexane, 1,3,5-trimethyl-2,4,6-tris(3,5-di-tert-butyl-4-hydroxybenzyl)benzene, tris(2-methyl-4-hydroxy-5-tert-butylphenyl)butane, tetrakis[methylene(3,5-di-tert-butyl-4-hydroxyhydrocinnamate)]methane, octadecyl-3,5-di-tert-butyl-4-hydroxyhydrocinnamate, etc.

[0073] The volatility modifier is not particularly limited, and examples thereof include tricyclodecane, cyclododecane, 2,4,6-triisopropyl-1,3,5-trioxane, and trimethylene norbornene.

[0074] The antioxidant is not particularly limited, and examples thereof include butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), ascorbic acid, diethyl (3,5-di-tert-butyl-4-hydroxybenzyl) phosphonate, and vitamins.

[0075] Bactericides and mildew inhibitors are not particularly limited, and examples thereof include isopropylmethylphenol, parachloro-m-xylenol, triclosan, 3-iodomethyl-2-propenylbutylcarbamate, 2-(4-thiazolyl)benzimidazole, cetylpyridinium chloride, 4,4-dimethyl-1,3-oxazolidine, polyhexamethylene biguanide hydrochloride, hinokitiol, and essential oils such as oregano oil, cinnamon oil, lemongrass oil, peppermint oil, and eucalyptus oil.

[0076] The deodorant or deodorant is not particularly limited, and examples thereof include lauryl methacrylate, geranyl crotonate, catechin, and polyphenol.

[0077] The aromatic agent can be any of natural or synthetic spices, or a blended spice. In addition, the type of the spice can also be any of animal or plant spices.

[0078] Natural fragrances are not particularly limited, and examples thereof include animal fragrances such as musk, civet, and ambergris; and plant fragrances such as rose oil, lavender oil, rosemary oil, peppermint oil, lemon oil, pine needle oil, celery oil, almond oil, angelica root oil, basil oil, bergamot oil, birch oil, rosewood oil, melaleuca oil, ylang-ylang oil, chili oil, caraway oil, cardamom oil, quassia oil, celery oil, cinnamon oil, citronella oil, konjac oil, coriander oil, cubeb oil, garlic oil, ginger oil, grapefruit oil, hop oil, juniper berry oil, bay leaf oil, lemongrass oil, lovage oil, mace oil, nutmeg oil, orange oil, tangerine oil, mustard oil, neroli oil, onion oil, pepper oil, orange oil, sage oil, star anise oil, turpentine oil, wormwood oil, and vanilla oil.

[0079] There are no particular limitations on synthetic fragrances or blended fragrances, and examples include: hydrocarbons such as pinene and limonene; alcohols such as linalool, geraniol, citronellol, menthol, borneol, benzyl alcohol, and anise alcohol; phenols such as anethole and eugenol; aldehydes such as n-butyraldehyde, isobutyraldehyde, citral, citronellal, benzaldehyde, cinnamaldehyde, and vanillin; ketones such as carvone, menthone, and camphor; lactones or oxides such as amyl butyrolactone, ethyl methylphenyl glycidate, γ-nonyl lactone, coumarin, and cineole; esters such as isopropyl isobutyrate, geranyl isovalerate, ethyl myristate, ethyl benzoate, benzyl benzoate, cinnamyl cinnamate, and methyl salicylate.

[0080] The coloring material is not particularly limited, and examples thereof include Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 223, Red No. 225, Orange No. 201, Orange No. 206, Yellow No. 204, Green No. 202, Red No. 505, Orange No. 401, Orange No. 403, Yellow No. 401, Yellow No. 402, Yellow No. 404, Yellow No. 405, Blue No. 403, and Violet No. 201.

[0081] The control composition in this embodiment is preferably a liquid in order to be absorbed into a carrier such as a liquid absorbent wick or a pad, and preferably has a boiling point in the range of 130°C to 350°C.

[0082] It should be noted that, in this specification, liquid refers to a substance that flows and can change shape according to the shape of a container.

[0083] The raw material of the carrier is not particularly limited, and various raw materials such as inorganic raw materials and organic raw materials can be used.

[0084] When a wick is used as a carrier, examples of the inorganic material include clay, talc, kaolin, acid clay, diatomaceous earth, activated clay, gypsum, perlite, bentonite, alumina, silica, titanium, asbestos, and ceramics.

[0085] When using a liquid absorbent wick as a carrier, examples of the organic material include wood flour, cellulose, pulp, polymer resins such as polyester resins and acrylic resins. Of these, at least one selected from polyester resins and acrylic resins is preferred. When forming a liquid absorbent wick, a synthetic fiber wick formed by aggregating these fibers is more preferred, and the porosity is even more preferably 20% to 80%.

[0086] When a pad is used as a carrier, examples of inorganic materials include paper obtained from inorganic fibers such as glass and asbestos, non-woven fabrics, graphite, CaCO3, SiO2, Al2O3, perlite, kaolin, talc, sepiolite, bentonite and other inorganic powders; sintered metals, etc.

[0087] When a mat is used as a carrier, examples of the organic material include natural fibers such as cotton linter and pulp; animal and plant fibers such as wool, cotton, and silk; regenerated fibers such as rayon; synthetic fibers such as acrylic and polyester; and plastic foams such as polyethylene and polyvinylidene fluoride.

[0088] The form of the carrier is not particularly limited. For example, in the case of a liquid-absorbing wick, the carrier may be in the form of a strip, a tube, or a rod.

[0089] The volatilization in this embodiment can be performed by a conventionally known method.

[0090] For example, when using a wick to absorb liquid, the wick is mounted on a bottle filled with the control composition of this embodiment, so that the control composition and the wick come into contact with each other, thereby forming a wick containing the control composition. Alternatively, when using a pad to absorb liquid, the control composition of this embodiment is impregnated into the pad. The wick or pad containing the control composition is then placed in each device for volatilization, and volatilized using a method consistent with the dosage form. For example, when volatilization is performed by heating and evaporation, heating by energizing the pad can be used.

[0091] When the wick is used for volatilization, the control composition absorbed by the wick volatilizes, thereby releasing the pyrethroid compound into the gas. At this time, by maintaining the concentration of the pyrethroid compound in the air at 1 μg / m 3 ~100 μg / m 3 Within the range, it can prevent crawling pests from staying in the space.

[0092] The present invention also relates to a creeping pest control agent comprising the above control composition.

[0093] The creeping insect pest control agent is used to prevent creeping insects from settling in a space, and comprises a control composition containing a pyrethroid compound as an active ingredient.

[0094] The creeping pest control agent can volatilize the active ingredients into the space, so that the concentration of the active ingredients in the gas in the space is 1μg / m 3 ~100 μg / m 3 This prevents crawling pests from settling in the space. One form of the crawling pest control agent includes one that uses thermal evaporation as a volatilization method, i.e., a heated evaporation agent that includes a heated evaporation device. However, this is not limited to the above form. For example, a natural evaporation agent, a fan-type agent, or a piezoelectric automatic spray agent may also be used.

[0095] In addition to preventing creeping pests from settling in a space, the control method of this embodiment also has the effect of inhibiting the activity, feeding, and proliferation of creeping pests.

[0096] By inhibiting the activity and feeding of creeping pests, the chances of contact between creeping pests and residents or food kept by residents are reduced, thereby suppressing the spread of pathogens.

[0097] By exerting a proliferation inhibition effect, the reproduction of pests in the treatment space can be suppressed, and long-term pest control in the treatment space can be achieved.

[0098] That is, the present invention also relates to a method for inhibiting the activity of creeping pests, which comprises volatilizing a control composition containing a pyrethroid compound, wherein the concentration of the pyrethroid compound in the air in the space is maintained at 1 μg / m 3 ~100 μg / m 3 within the range.

[0099] In the method for suppressing the activity of creeping insect pests of this embodiment, for example, when the creeping insect pests are cockroaches, the concentration of the pyrethroid compound in the air in the space is maintained at 1 μg / m 3 ~100 μg / m 3 Within the range, it will not cause the increase in activity rate associated with neural excitement, but can inhibit wandering behavior and reproductive behavior in space.

[0100] The maintenance time is preferably 2 hours or longer, more preferably 4 hours or longer, and even more preferably 6 hours or longer.

[0101] In the method for suppressing the activity of creeping insect pests of this embodiment, for example, when the creeping insect pests are mites, the concentration of the pyrethroid compound in the air in the space is maintained at 1 μg / m 3 ~100 μg / m 3 Within the range, it will not cause the increase in activity rate associated with neural excitement, but can inhibit wandering behavior and reproductive behavior in space.

[0102] The maintenance time is preferably 3 days or longer, more preferably 5 days or longer, and even more preferably 7 days or longer.

[0103] In addition, the present invention also relates to a method for inhibiting the feeding of creeping pests, which comprises volatilizing a control composition containing a pyrethroid compound, wherein the concentration of the pyrethroid compound in the gas in the space is maintained at 1 μg / m by volatilizing the control composition into the space. 3 ~100 μg / m 3 within the range.

[0104] In the method for suppressing feeding of creeping insect pests of this embodiment, for example, when the creeping insect pests are cockroaches, the concentration of the pyrethroid compound in the air in the space is maintained at 1 μg / m 3 ~100 μg / m 3 Within the range, it can reduce the cockroach's appetite and inhibit eating.

[0105] The maintenance time is preferably 2 hours or longer, more preferably 4 hours or longer, and even more preferably 6 hours or longer.

[0106] In the method for inhibiting feeding of creeping insect pests of this embodiment, for example, when the creeping insect pests are mites, the concentration of the pyrethroid compound in the air in the space is maintained at 1 μg / m 3 ~100 μg / m 3 Within this range, it can reduce the appetite of mites and inhibit eating.

[0107] The maintenance time is preferably 3 days or longer, more preferably 5 days or longer, and even more preferably 7 days or longer.

[0108] In addition, the present invention also relates to a method for inhibiting the proliferation of creeping pests, which comprises volatilizing a control composition containing a pyrethroid compound, wherein the concentration of the pyrethroid compound in the gas in the space is maintained at 1 μg / m by volatilizing the control composition into the space. 3 ~100 μg / m 3 within the range.

[0109] In the method for suppressing the proliferation of creeping insect pests of the present embodiment, the period for maintaining the concentration in the gas is appropriately set according to the egg-laying pattern of the creeping insect pests.

[0110] For example, when the creeping pest is German cockroach, it starts to lay eggs about 1 to 2 weeks after the German cockroach emerges. Therefore, by maintaining the concentration of pyrethroid compounds in the air at 1 μg / m 3 ~100 μg / m 3 The period within the range of preferably 1 week or more, more preferably 2 weeks or more, can appropriately suppress the proliferation of cockroaches such as German cockroaches. In addition, when the crawling pests are mites, it is also preferred to maintain the concentration of the pyrethroid compound in the air at 1 μg / m 3 ~100 μg / m 3 The period within the range of 1 week or more, more preferably 2 weeks or more. For other creeping insect pests, it is also possible to consider the periods from emergence or hatching to egg gestation, and appropriately set the concentration of pyrethroid compounds in the air in the space to be maintained at 1 μg / m 3 ~100 μg / m 3 period within the scope of .

[0111] The growth inhibitory effect refers to an effect of inhibiting at least one selected from the group consisting of female egg laying, female egg incubation, and larvae emergence or hatching from eggs or oothecae, preferably inhibiting two or more of the above-mentioned effects, and more preferably inhibiting all of them.

[0112] In the aforementioned methods for inhibiting activity, inhibiting feeding, and inhibiting growth, the method for volatilizing the control composition is not particularly limited, and suitable examples include natural vaporizers, fan-type formulations, piezoelectric automatic spray formulations, and heated vaporizers. When these methods are used in conjunction with the aforementioned method for controlling creeping pests, a heated vaporizer is preferably used as the formulation from the perspective of maintaining a constant concentration in the gas throughout the entire space.

[0113] Example

[0114] Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples.

[0115] Stop and Stop Evaluation 1

[0116] [Preparation of Samples 1 to 7]

[0117] The ingredients were mixed according to the formulation shown in Table 1 to prepare samples 1 to 7 as control compositions.

[0118] [Table 1]

[0119] Table 1 (unit: w / v%)

[0120] Mixing ingredients Sample 1 Sample 2 Sample 3 Sample 4 Sample 5 Sample 6 Sample 7 Metofluthrin 0.4 1.2 4.8 9.6 － 0.1 17 Paraffinic hydrocarbon solvents The rest Remaining The rest The rest The rest The rest Remaining total 100mL 100mL 100mL 100mL 100mL 100mL 100mL

[0121] [Manufacturing of Heating Evaporative Agent]

[0122] 50 mL PET (polyethylene terephthalate) containers were filled with 45 mL of each of Samples 1 to 7 and sealed with an inner stopper equipped with a wick (approximately 7.2 mm diameter x approximately 73.5 mm length). These containers were then attached to a heating evaporator (Earth No-mat, manufactured by As Pharmaceutical Co., Ltd.) to produce the heating evaporant. The heating temperature of the heating evaporator was 140°C.

[0123] [Examples 1 to 4 and Comparative Examples 1 to 3]

[0124] Using the heating evaporants of samples 1 to 7, creeping insect pest stop prevention and knockdown tests were conducted by the following methods (1) to (7). The results are shown in Table 2. In Table 2, "-" means not tested.

[0125] (1) A partition 10 is installed in a 12-tatami test room (length 3.6m × width 5.4m × height 2.4m). Figure 1 As shown, the test chamber is divided into a 4-tatami test space A and an 8-tatami test space B. A 1.5 cm high opening 20 is provided in the lower center of the partition 10 to allow the specimen insects to move back and forth between test space A and test space B. The test chamber is maintained at a temperature of 25±5°C, a humidity of 50-70% RH, and ventilation conditions of 0.5 times / hour.

[0126] (2) A shelter 12, water 13, and solid bait 14 are provided in the test space B.

[0127] (3) 20 male and female adult Periplaneta fuliginosa or 25 male and female German cockroaches were released as sample insects for acclimation in test space A. It should be noted that during the acclimation period, the opening 20 of the partition 10 was closed to prevent the sample insects from moving from test space A to test space B.

[0128] (4) In the test space B, the heating evaporators 11 using the samples 1 to 7 obtained above were set as heating evaporators.

[0129] (5) Open the closed opening 20 to allow the sample insects to move freely. Simultaneously with the opening, start energizing the heating evaporator and continue energizing for 12 hours. Then, the number of sample insects present in test space A and test space B 12 hours after the start of energization is measured as the number of settled insects. It should be noted that sample insects that are killed or knocked down are measured as the number of knocked down insects and are not included in the above-mentioned number of settled insects.

[0130] (6) As a control, the number of standing still in the test space B when no heating evaporator using a sample is provided is measured. This corresponds to the "case of untreated sample" in the following formula (I).

[0131] (7) Using the following formula (I) and formula (I)', the stop prevention rate (%) was calculated from the number of stops, and the knockdown rate (%) was calculated from the number of knockdowns. Note that the test was performed twice, and the average value was used as the stop prevention rate.

[0132] Formula (I): Stoppage prevention rate (%) = {1-(number of stops in test space B when the sample is treated / number of stops in test space B when the sample is not treated)} × 100

[0133] Formula (I): Knockdown rate (%) = (number of knockdowns) / (number of sample insects) × 100

[0134] [Measurement of gas concentration]

[0135] In the foot-stopping effectiveness test of Examples 1 to 4 and Comparative Examples 1 to 3 using the above-mentioned samples 1 to 7, the concentration of metofluthrin in the gas in the test space B was measured by the following methods (1) to (3). The results are shown in Table 2.

[0136] (1) Each heated evaporator 11 using samples 1 to 7 was placed in test space B. (2) After the heated evaporator 11 was energized for at least 4 hours to stabilize the concentration of metofluthrin in the test space B, the air in the test space B was aspirated at a rate of 10 L / min for 2 hours. The metofluthrin was captured using the silica gel trap described below. The aspiration was performed while the open end of the silica gel trap was fixed at a distance of 100 cm from the wall of the test space B facing the partition 10 and at a height of 20 cm from the ground.

[0137] ·Silica gel trap

[0138] One end of a glass tube (18 mm inner diameter, 100 mm length) was filled with absorbent cotton and filled with about 4 g of silica gel (Wakogel C-100; Wako Pure Chemical Industries, Ltd.) and the other end was sealed with new absorbent cotton to obtain a silica gel trap.

[0139] (3) Metofluthrin was washed out with acetone and quantitatively analyzed by gas chromatography (Shimadzu Corporation, Model GC-2014). The concentration of metofluthrin in the gas in the test space B (μg / m 3 It should be noted that the test was carried out twice, and the average value was used as the concentration of metofluthrin in the gas in the test space B.

[0140] Formula (II): Concentration in gas (μg / m 3 )=R(μg)×1000(L / m 3 ) / S(L)

[0141] In the above formula (II), R is the quantitative value of metofluthrin (μg), and S is the amount of air sucked (L).

[0142] [Table 2]

[0143] Table 2

[0144]

[0145] As shown in the results of Table 2, the concentration of metofluthrin in the gas used as the active ingredient of the control composition was 1 μg / m 3 ~100 μg / m 3 In Examples 1 to 4 of Samples 1 to 4, although the sample insects sometimes temporarily intruded into the test space B having the shelter 12, water 13, and solid bait 14, no settling was observed. On the other hand, the concentration of metofluthrin in the gas was less than 1 μg / m 3 In Comparative Examples 1 and 2 of Samples 5 and 6, the phenomenon of sample insects settling in the test space B was observed. In addition, the concentration of metofluthrin in the gas exceeded 100 μg / m 3 In Comparative Example 3 of Sample 7, the specimen insects were observed to be neurologically excited, unable to adopt normal behavior and, as a result, unable to move outside of test space B, confirming a reduction in the stopping effect. Furthermore, in Comparative Example 3, many specimen insects were observed to have been killed or knocked down, resulting in the remains of crawling insects in both test spaces A and B.

[0146] The results show that the concentration of the pyrethroid compound in the gas, which is an active ingredient of the control composition, is maintained at 1 μg / m 3 ~100 μg / m 3 The space will not cause nervous excitement to crawling pests or leave corpses in the space, and a high stopping effect of the black cockroach and the German cockroach in the space is exerted.

[0147] The above test was conducted using common German cockroaches, also known as susceptible German cockroaches, as sample insects. However, similar evaluations were performed using insecticide-resistant German cockroaches instead of susceptible German cockroaches, and the same stopping-preventing effect was confirmed.

[0148] [Stop and prevent evaluation (on the ground)]

[0149] Use of restaurant (floor area 45m 2The effectiveness of the cockroach control composition in preventing cockroaches from settling in a kitchen (2.7 m x 2.7 m in height) was evaluated. Specifically, a heated vaporizer using Sample 2 and a cockroach sticky trap were placed in the kitchen. The heated vaporizer was energized for 12 hours, allowing the control composition in Sample 2 to evaporate into the kitchen. The number of German cockroaches captured by the cockroach sticky trap was used as an indicator to evaluate the effectiveness of the control composition in preventing cockroaches from settling in the kitchen. The evaluation was based on the number of German cockroaches captured by the cockroach sticky trap when only the cockroach sticky trap was installed, without the heated vaporizer.

[0150] The results showed that the use of the heated evaporator using Sample 2 significantly reduced the number of German cockroaches captured. Furthermore, no fatalities or knockdowns of German cockroaches were observed during the use of the heated evaporator. Therefore, it is believed that German cockroaches migrated from the kitchen to the outside, preventing them from settling inside.

[0151] The results show that the device can also achieve a high stopping effect in actual use environments where cockroaches live in large numbers and there are obstacles such as sinks and refrigerators.

[0152] Stop and Stop Review 2

[0153] [Preparation of Samples 8 and 9]

[0154] Samples 8 and 9 were prepared as control compositions by mixing the ingredients according to the formulation shown in Table 3. Note that Sample 5 in Table 3 is the same as Sample 5 in "Standing Prevention Evaluation 1".

[0155] [Table 3]

[0156] Table 3 (unit: w / v%)

[0157] Mixing ingredients Sample 8 Sample 9 Sample 5 Transfluthrin 1.0 4.0 － Paraffinic hydrocarbon solvents The rest The rest The rest total 100mL 100mL 100mL

[0158] [Manufacturing of Heating Evaporative Agent]

[0159] 50 mL PET (polyethylene terephthalate) containers were filled with 45 mL of each of Samples 8 and 9 and sealed with an inner stopper equipped with a wick (approximately 7.2 mm diameter x approximately 73.5 mm length). These containers were then attached to a heating evaporator (Earth No-mat, manufactured by As Pharmaceutical Co., Ltd.) to produce a heating evaporant. The heating temperature of the heating evaporator was 140°C.

[0160] [Examples 5, 6 and Comparative Example 1]

[0161] Using the heated evaporative agents of Samples 8 and 9, creeping insect pest stationing deterrent and knockdown tests were conducted in the same manner as in Examples 1-4 and Comparative Examples 1-3. Only 20 male and female adult Periplaneta fuliginosa were used as the sample insects. The results are shown in Table 4. For comparison, the results of Comparative Example 1, which used the heated evaporative agent of Sample 5, are also shown.

[0162] In the standstill prevention efficacy tests of Examples 5 and 6 using Samples 8 and 9, the concentration of transfluthrin in the gas in test space B was measured using the same method except that the metofluthrin in the "Measurement of Gas Concentration" was replaced with transfluthrin. The results are shown in Table 4. For comparison, the results of Comparative Example 1, which used the heated evaporator consisting of Sample 5, are also shown.

[0163] [Table 4]

[0164] Table 4

[0165]

[0166] As shown in the results in Table 4, it was shown that, by maintaining the concentration of not only metofluthrin but also transfluthrin in the gas as the active ingredient of the control composition within a specific range, a high effect of preventing Periplaneta fuliginosa from settling in the space was exerted.

[0167] Stop and Stop Review 3

[0168] [Preparation of Sample 10]

[0169] The ingredients were mixed according to the formulation shown in Table 5 to prepare Sample 10 as a control composition. It should be noted that Samples 5 and 7 in Table 5 are the same as Samples 5 and 7 in "Standing Prevention Evaluation 1", respectively.

[0170] [Table 5]

[0171] Table 5 (unit: w / v%)

[0172] Mixing ingredients Sample 10 Sample 5 Sample 7 Metofluthrin 2.4 － 17 Paraffinic hydrocarbon solvents Remaining Remaining Remaining total 100mL 100mL 100mL

[0173] [Manufacturing of Heating Evaporative Agent]

[0174] 50 mL PET (polyethylene terephthalate) containers were filled with 45 mL of Sample 10 and sealed with an inner stopper equipped with a wick (approximately 7.2 mm in diameter and approximately 73.5 mm in length). These containers were attached to a heating evaporator (Earth No-mat, manufactured by As Pharmaceutical Co., Ltd.) to produce a heating evaporant. The heating temperature of the heating evaporator was 140°C. The heating evaporant used in Samples 5 and 7 was the same as that used in Samples 5 and 7 in "Standstilling Prevention Evaluation 1."

[0175] [Example 7 and Comparative Examples 4 and 5]

[0176] Using the heated evaporants using Samples 10, 5, and 7, respectively, creeping insect pest deterrent and knockdown tests were conducted in the same manner as in Examples 1-4 and Comparative Examples 1-3. Twenty leafcutter ants (Ceratotherium striata) were used as the sample insects. The results are shown in Table 6.

[0177] For the standstill deterrent efficacy tests of Example 7, Comparative Examples 4, and Comparative Examples 5 using Samples 10, 5, and 7, the gaseous concentration of metofluthrin in test space B was measured using the same method as described in [Measurement of Gas Concentration] above. The results are shown in Table 6.

[0178] [Table 6]

[0179] Table 6

[0180]

[0181] As shown in Table 6, the results show that, for creeping insects such as the leafcutter ant, the effective ingredient of the control composition is maintained in a specific range in the air, without causing nerve excitement or leaving carcasses in the air, and a high stopping effect is exerted in the space. On the other hand, when the concentration of metofluthrin in the air exceeds 100 μg / m 3 In Comparative Example 5 of Sample 7, a large number of deaths or knockdowns were observed, resulting in a large number of corpses of creeping pests such as the leaf-cutter ants remaining in the air.

[0182] Stop and Stop Review 4

[0183] [Example 8 and Comparative Example 6]

[0184] A test of the stopping effect of the creeping pest, Scolopendra harveyi, was conducted using the heating evaporators using Sample 2 in Example 2 and Sample 7 in Comparative Example 3. The stopping effect test was conducted by the following methods (1) to (7).

[0185] (1) A 12-tatami test chamber (3.6 m long × 5.4 m wide × 2.4 m high) was divided into a 4-tatami test chamber A and an 8-tatami test chamber B by installing a partition. A 1.5 cm high opening was provided in the center of the lower portion of the partition to allow the specimen insects to move back and forth between test chambers A and B. The test chamber was maintained at a temperature of 25 ± 5°C, a humidity of 50-70% RH, and ventilation conditions of 0.5 times / hour.

[0186] (2) A shelter is set up in the test space B. The shelter is moistened with water so that the specimen insect, the Scolopendra harzianus, can easily land there.

[0187] (3) A single centipede was released as a sample insect into test space A and acclimated. During the acclimation period, the opening of the partition was closed so that the sample insect could not move from test space A to test space B.

[0188] (4) The heating evaporator using the sample 2 or the sample 7 obtained above was set in the test space B as the heating evaporator.

[0189] (5) After the heated evaporator is energized and the concentration of the metofluthrin gas in the test space B is confirmed to be stable, the closed opening is opened to allow the specimen insects to move freely back and forth. The test is marked as the start of the test. The average residence time of the specimen insects in the shelter within the test space B is measured by visual observation 3 minutes after the start of the test. In addition, the resting places of the specimen insects are observed 12 hours after the start of the test.

[0190] (6) As a control, the test space B was set to an untreated state in which no heating evaporator was used for the sample. Similarly, the test started when the sample insects first invaded the test space B. The average residence time in the shelter in the test space B was measured by visual observation 3 minutes after the start of the test. In addition, the residence places of the sample insects were observed 12 hours after the start of the test.

[0191] (7) The above test was conducted twice. It should be noted that the purpose of using one centipede as a sample insect and conducting the test twice was to prevent cannibalism among the centipedes that would result from using multiple centipedes at once.

[0192] The results are shown in Table 7.

[0193] [Table 7]

[0194] Table 7

[0195]

[0196] As shown in the results in Table 7, the Habitatus harris prefers to reside in dark, humid places such as shelters due to its habitual habit. However, the results of the above test showed that in Example 8, the average residence time of the specimen insects in the shelter within test space B was 0.4 minutes three minutes after the start of the test. In contrast, in the control, which did not use a heated evaporator containing a sample, the average residence time of the specimen insects in the shelter within test space B was 3 minutes.

[0197] Furthermore, 12 hours after the start of the test, the sample insects in Example 8 stayed in the test space A twice, whereas in the control, they stayed in the shelter in the test space B twice.

[0198] On the other hand, as shown in Comparative Example 6, although the concentration in the gas was as high as more than 100 μg / m 3 , but the result is not that it stops in the test space A where no heating evaporant is set, but that it stops in the test space B where the heating evaporant is set.

[0199] In Comparative Example 6, approximately one hour after the start of the test, the specimen insects were observed moving back and forth between test spaces A and B and grooming in the corners of test space B. Furthermore, 12 hours after the start of the test, specimen insects were observed to be knocked down in test space B. This is believed to be due to the specimen insects being exposed to the control composition in test space B, which prolonged their grooming time in the corners of test space B, resulting in an increased probability of knocking down in test space B. Furthermore, prior to the knockdown, the specimen insects, Scolopendra harzianus, were observed to be experiencing neurological excitement.

[0200] Thus, it was confirmed that if the concentration in the gas exceeds 100 μg / m 3 , which is accompanied by the nerve excitement of the Hartspathi centipede, causing discomfort and fear to the residents, and increasing the risk of bite injuries and the possibility of corpses remaining in the space.

[0201] As shown in the above results, it is shown that even for the creeping pest Scolopendra harzianum, by maintaining the concentration of the active ingredient in the gas of the control composition within a specific range in the space, it does not cause nerve excitement or leave corpses in the space, and a high stopping prevention effect is exerted in the space.

[0202] Stop and Stop Review 5

[0203] [Preparation of Samples 11 and 12]

[0204] The components were mixed according to the formulation shown in Table 8 to prepare samples 11 and 12 as control compositions.

[0205] [Table 8]

[0206] Table 8 (unit: w / w%)

[0207] Mixing ingredients Sample 11 Sample 12 Metofluthrin 70 － Paraffinic hydrocarbon solvents The rest The rest total 100g 100g

[0208] [Manufacturing of natural evaporating agents]

[0209] A PET (polyethylene terephthalate) mesh carrier (14 cm long x 27 cm wide, 15% open area) was fixed to a plastic frame (17.5 cm long x 31.5 cm wide), and 1500 mg of sample 11 or sample 12 was dripped onto the mesh carrier to impregnate it, thereby producing a natural evaporator.

[0210] [Example 9 and Comparative Example 7]

[0211] Using the natural vaporizers using samples 11 and 12, a settling prevention efficacy test and a knockdown test on creeping insects were conducted.

[0212] Specifically, the aforementioned natural evaporator was used instead of the heated evaporator. The natural evaporator was placed near the center of test space B, in a well-ventilated area 120 cm above the ground with a wind speed of approximately 0.1 m / s. The test was conducted under the same conditions as those in the "Standstillness Prevention Evaluation 1" for the standstill prevention effectiveness test and knockdown test. The results are shown in Table 9.

[0213] [Table 9]

[0214] Table 9

[0215]

[0216] As shown in the results of Table 9, even when using a natural evaporator, the concentration of metofluthrin in the gas was 1 μg / m 3 ~100 μg / m 3 In Example 9 of Sample 11, although the sample insects sometimes temporarily invaded the test space B, no phenomenon of staying there was observed.

[0217] The results show that the concentration of the pyrethroid compound in the gas as the active ingredient of the control composition was maintained at 1 μg / m by using a natural evaporator. 3 ~100 μg / m 3 The space will not cause nervous excitement to crawling pests or leave corpses in the space, and a high stopping effect will be exerted in the space.

[0218] Stop and Stop Review 6

[0219] [Preparation of Samples 13 and 14]

[0220] The components were mixed according to the formulation shown in Table 10 to prepare samples 13 and 14 as control compositions.

[0221] [Table 10]

[0222] Table 10 (Unit: w / w%)

[0223] Mixing ingredients Sample 13 Sample 14 Transfluthrin 80 － Ester solvents Remaining The rest total 100g 100g

[0224] [Manufacturing of fan-type preparations]

[0225] On a mesh carrier (14 cm) made of PET (polyethylene terephthalate) 2 ) was coated with 150 mg of sample 13 or sample 14 and fixed in a drug volatilization device (Osoto de Nomat, manufactured by As Pharmaceutical Co., Ltd.) to produce a fan-type preparation. The fan of the fan-type preparation had a diameter of 6 cm and a wind speed of 0.5 m / s.

[0226] [Example 10 and Comparative Example 8]

[0227] Using the fan-type formulations using samples 13 and 14, a settling prevention efficacy test and a knockdown test on creeping insects were conducted.

[0228] Specifically, the same conditions as those for the "Standstill Prevention Efficacy Test and Knockdown Test" in "Standstill Prevention Evaluation 1" were used, except that the fan of the aforementioned fan-type formulation was used instead of the heated vaporizer. The fan of the fan-type formulation was positioned so that air flowed toward the opening 20 of the partition 10 in the test chamber. The results are shown in Table 11.

[0229] [Table 11]

[0230] Table 11

[0231]

[0232] As shown in the results of Table 11, even when the fan-type preparation was used, the concentration of transfluthrin in the gas was 1 μg / m 3 ~100 μg / m 3 In Example 10 of Sample 13, although the sample insects sometimes temporarily invaded the test space B, no phenomenon of staying there was observed.

[0233] The results show that the concentration of the pyrethroid compound as the active ingredient of the control composition in the air was maintained at 1 μg / m 3 ~100 μg / m 3 space, and exert a high stopping effect on crawling pests in the space.

[0234] It should be noted that the concentration of transfluthrin in the gas is 0 μg / m 3 In Comparative Example 8, the stopping rate was 10.7%. This is probably because the wind generated by the fan-type preparation reached the vicinity of the opening 20 between the test space A and the test space B, hindering the movement of the sample insects to the test space B.

[0235] Activity inhibition evaluation 1

[0236] The activity-inhibiting effect on cockroaches was evaluated by the following methods (1) to (3). The results are shown in Table 12.

[0237] (1) Regarding Samples 2 and 5 shown in Table 12, heating evaporants using Samples 2 and 5 were prepared in the same manner as described above.

[0238] (2) In an 8-tatami test room (3.6m long x 3.6m wide x 2.4m high), if Figure 2 As shown, heating evaporators using samples 2 and 5 were set, and five male and female adult Periplaneta fuliginosa were released as sample insects.

[0239] (3) Each heating evaporator was energized for 4 hours to heat and evaporate the control composition into the test chamber. After energization, the presence of the sample insects was visually confirmed for 1 minute, and the activity rate (%) was calculated using the following formula (III). It should be noted that the concentration of metofluthrin in the gas during heating and evaporation using the heating evaporator of sample 2 was 10 μg / m 3 .

[0240] In this specification, wandering of a specimen insect refers to the behavior of moving a certain distance in search of food or water. Furthermore, the "number of specimen insects observed wandering in 1 minute" in the following formula (III) refers to the number of specimen insects that moved 10 cm or more during the 1-minute visual observation period.

[0241] Formula (III): Activity rate (%) = (number of sample insects observed wandering in 1 minute / number of surviving insects) × 100

[0242] [Table 12]

[0243] Table 12 (unit: w / v%)

[0244] Mixing ingredients Sample 2 Sample 5 Metofluthrin 1.2 － Paraffinic hydrocarbon solvents Remaining Remaining total 100mL 100mL Activity rate (%) 0 70

[0245] From the above results, it was confirmed that the activity of cockroaches was significantly reduced by using the heated evaporator using Sample 2. In addition, no cockroaches were killed or knocked down.

[0246] By maintaining the concentration of the pyrethroid compound in the air within a specific range, the activity of creeping pests can be reduced without causing nerve excitement, knockdown, or death due to the pyrethroid compound.

[0247] Activity Inhibition Evaluation 2

[0248] The inhibitory effect on mite activity was evaluated by the following methods (1) to (6). The results are shown in Table 14.

[0249] (1) Samples 15 and 5 were prepared as control compositions by mixing the components according to the formulation shown in Table 13. Heat evaporants using Samples 15 and 5 were prepared in the same manner as above.

[0250] (2) A humidity control tank (43.4 cm long × 31 cm wide × 14.3 cm high) was installed approximately 40 cm diagonally from a corner of a 4-tatami test room (1.8 m long × 3.6 m wide × 2.4 m high). A 4-cm-diameter petri dish containing approximately 500 dust mites as a sample was placed in the humidity control tank. The temperature and humidity in the test room were set at 26±2°C and 60-80% RH, and the temperature and humidity in the humidity control tank were set at 25°C and 75% RH.

[0251] (3) Each heating evaporator was energized to start heating and evaporating the control composition into the test chamber, and the culture dish was collected after 7 days. The ventilation frequency was set to 0.5 times / hour. In addition, the concentration of transfluthrin in the gas during heating and evaporation using the heating evaporator of sample 15 was set to 14 μg / m 3 .

[0252] (4) As a control, a 4 cm diameter Petri dish containing approximately 500 dust mites as a sample was placed in the humidity control tank without the use of a heated evaporator for the sample, i.e., as a non-treated area. Similarly, the Petri dish was collected after 7 days. The ventilation rate was set at 0.5 times / hour.

[0253] (5) Ten dust mites were placed in a 1 cm square area from the recovered culture dish and a 30-second video was recorded using a microscope (manufactured by KEYENCE Co., Ltd.). The four squares were made with vaseline. The recorded video was analyzed using tracking software (TPro, Pudith Sirigrivatanawong et al. Sensors 2017, 17(1), 96).

[0254] (6) Repeat (5) above three times to evaluate the activity of 18 to 30 dust mites that can be tracked. Then, the average mobility of each dust mite per minute is calculated. Furthermore, the ratio (mobility ratio) of the average mobility of the samples 15 and 5 treated with the heated evaporative agent to the average mobility of the untreated control is calculated.

[0255] [Table 13]

[0256] Table 13 (Unit: w / v%)

[0257] Mixing ingredients Sample 15 Sample 5 Transfluthrin 2.0 － Paraffinic hydrocarbon solvents Remaining Remaining total 100mL 100mL

[0258] [Table 14]

[0259] Table 14

[0260] sample Sample 15 Sample 5 No treatment area Average moving average 317.6 455.4 486.7 Mobile ratio 0.65 0.94 －

[0261] From the above results, it was confirmed that the activity of mites was significantly reduced by using the heated evaporative agent using Sample 15. In addition, no mortality or knockdown of mites was observed.

[0262] By maintaining the gaseous concentration of pyrethroid compounds in the space within a specific range, the movement, ie, activity, of crawling pests can be reduced without causing nerve excitement, knockdown, or death due to pyrethroid compounds.

[0263] Feeding Suppression Evaluation 1

[0264] The cockroach feeding inhibitory effect was evaluated by the following methods (1) to (3). The results are shown in Table 15.

[0265] (1) In an 8-tatami test room (3.6m long x 3.6m wide x 2.4m high), 50 adult male German cockroaches were released as test insects. Figure 2 As shown, a heating evaporant was installed in the test chamber using sample 2. The test chamber in which the heating evaporant was installed was used as a treatment zone, and for comparison, a test chamber in which no heating evaporant was installed was also prepared as a non-treatment zone.

[0266] (2) After acclimating German cockroaches overnight in the treated and untreated areas, water 13 and solid food 14 were placed in the test chamber. Note that, to correct for weight changes due to moisture absorption, a blank solid food (hereinafter referred to as blank, not shown) was placed in a location where the specimen insects could not feed.

[0267] (3) In the treatment area, the heating evaporator was energized for 12 hours to heat and evaporate the control composition. The weight of the solid bait 14 was measured 12 hours later, and the amount of food consumed (g) was calculated using the following formula (IV). The concentration of metofluthrin in the gas in the treatment area was 10 μg / m 3 For the untreated group, the weight of the solid food 14 was measured 12 hours after the start of the test, and the food intake was calculated using the following formula (IV). It should be noted that the test was carried out twice, and the average value was used as the food intake.

[0268] Formula (IV): Food intake (g) = (weight of blank after 12 hours / initial weight of blank) × initial weight of solid food - weight of solid food after 12 hours

[0269] [Table 15]

[0270] Table 15

[0271] Processing Area No treatment area Food intake after 12 hours (g) 0.07 0.13

[0272] The above results show that the use of the heated evaporator using Sample 2 resulted in a feeding amount of approximately 1 / 2 of that in the untreated group, indicating that a feeding inhibitory effect on cockroaches was observed.

[0273] Food Intake Suppression Review 2

[0274] The feeding inhibitory effect on mites was evaluated by the following methods (1) to (6). The results are shown in Table 16.

[0275] (1) As in (1) of "Inhibitory Activity Evaluation 2", the components were mixed according to the formulation shown in Table 13 to prepare samples 15 and 5 as control compositions. Heat evaporators using samples 15 and 5 were prepared in the same manner as above.

[0276] (2) A humidity control tank was set up at a position about 40 cm diagonally from the corner of a 4-tatami test room (length 1.8 m × width 3.6 m × height 2.4 m). A petri dish with a diameter of 4 cm was placed in the humidity control tank and provided with about 500 dust mites as a sample.

[0277] (3) Each heating evaporator was energized to start heating and evaporating the control composition into the test chamber, and the culture dish was collected after 5 days. The ventilation frequency was set to 0.5 times / hour. In addition, the concentration of transfluthrin in the gas during heating and evaporation using the heating evaporator of sample 15 was set to 14 μg / m 3 .

[0278] (4) As a control, a 4 cm diameter Petri dish containing approximately 500 dust mites as a sample was placed in the humidity control tank without the use of a heated evaporator for the sample, i.e., as a non-treated area. Similarly, the Petri dish was collected after 5 days. The ventilation rate was set at 0.5 times / hour.

[0279] (5) Quantification of allergen levels was performed using a high-sensitivity ELISA kit for mite allergens (Derf1) (manufactured by ITEA Co., Ltd.). Derf1 is an allergen derived from the feces of dust mites. First, the inner wall of the culture dish was cleaned with 3 mL of the phosphate buffer provided with the kit. The cleaning solution was filtered through gauze to remove impurities such as mite fragments, and the resulting solution was used as a test stock solution. This test stock solution was used to perform an ELISA to quantify the allergen levels.

[0280] (6) The total allergen concentration (ng / mL) obtained and the total number of mites tested were used to calculate the allergen concentration per 100 mites (ng / mL). This calculation was based on the assumption that the mites fed and excreted an equal amount and that all mites excreted equally. The feeding inhibition rate was calculated from the allergen concentration per 100 mites using the following formula (V).

[0281] Formula (V): Feeding suppression rate (%) = {1-(excretion amount after 5 days / excretion amount after 5 days in control test)}×100

[0282] ={1-(increase in allergens after 5 days / increase in allergens after 5 days in the control test)}×100

[0283] Here, when calculating the feeding inhibition rate (%), it would be preferable to directly measure the amount of food consumed. However, the amount of food consumed by mites is very small, making direct measurement extremely difficult. Therefore, excretion is used as an indicator of food intake. However, this excretion is also very small, making direct measurement extremely difficult. Therefore, as an alternative, the amount of allergen is measured using an antigen-antibody reaction to indirectly assess the feeding inhibition rate.

[0284] [Table 16]

[0285] Table 16

[0286]

[0287] 《Proliferation Inhibition Evaluation 1》

[0288] The growth inhibitory effect on cockroaches was evaluated by the following methods (1) to (3).

[0289] (1) As in the feeding inhibition evaluation, 40 German cockroach last-instar larvae were released as test insects in an 8-tatami test room (3.6 m long × 3.6 m wide × 2.4 m high). It should be noted that the male-female ratio of the emerged adults was similar in the untreated area and the treated area. Figure 2 As shown, a heating evaporant was installed in the test chamber using sample 2. The test chamber in which the heating evaporant was installed was used as a treatment zone, and for comparison, a test chamber in which no heating evaporant was installed was also prepared as a non-treatment zone.

[0290] (2) For German cockroaches, after acclimation overnight, water 13 and solid bait 14 were set in the test room.

[0291] (3) In the treatment area, the heating evaporator was energized continuously for 24 hours a day for 47 days, and the number of sample insects surviving was measured over time. In addition, the egg-laying rate and number of eggs laid by the sample insects were measured from the time of energization to the 20th day. The concentration of metofluthrin in the gas in the treatment area was 10 μg / m 3 In the untreated area, the number of surviving insects was measured over time from the start of the test for 47 days, and the egg-laying rate and number of eggs laid were measured until the 20th day.

[0292] The egg-carrying rate refers to the ratio of female adults carrying eggs to all surviving female adults. The number of eggs laid refers to the number of oothecae laid in the test room.

[0293] Figure 3 The time-dependent changes in the number of survivors are shown in Figure 4 The temporal changes in egg fertilization rate are shown in FIG. Figure 5 The temporal changes in the number of eggs laid are shown in FIG.

[0294] Depend on Figure 4 、 5 It can be seen that compared with the untreated area, the egg-laying rate in the treated area was lower and no egg laying was observed. Figure 5 Although it is difficult to see the results of the treatment area, it shows that the number of eggs laid was 0 during the entire 20 days of the experiment. Figure 3 As shown, in the untreated area, the number of larvae hatching from the laid eggs increased, while in the treated area, the number of individuals in the next generation did not increase.

[0295] The results confirmed that the use of the heated evaporator using Sample 2 suppressed cockroach proliferation. This is believed to be due to the suppressed cockroach activity, resulting in reduced feeding, increased natural mortality, and a lack of energy for egg laying and fertilization. Furthermore, the reduced egg fertilization rate suggests that not only is energy for egg fertilization lacking, but cockroach reproductive activity (mating, courtship, etc.) is also suppressed.

[0296] 《Proliferation Inhibition Evaluation 2》

[0297] The efficacy of inhibiting the proliferation of mites was evaluated by the following methods (1) to (6). The results are shown in Table 17.

[0298] (1) Samples 15 and 5 were prepared as control compositions by mixing the components according to the formulation shown in Table 13. Heat evaporants using Samples 15 and 5 were prepared in the same manner as above.

[0299] (2) A humidity control tank was set up at a position about 40 cm diagonally from the corner of a 4-tatami test room (length 1.8 m × width 3.6 m × height 2.4 m). A culture dish with a diameter of 4 cm was set up in the humidity control tank and provided with 30 female adult dust mites as samples.

[0300] (3) Each heating evaporator was energized to start heating and evaporating the control composition into the test chamber, and the culture dish was collected after 14 days. The ventilation frequency was set to 0.5 times / hour. In addition, the concentration of transfluthrin in the gas during heating and evaporation using the heating evaporator of sample 15 was set to 14 μg / m 3 .

[0301] (4) As a control, a 4 cm diameter Petri dish containing 30 adult female Dermatophagoides farinae was placed in the humidity control tank without the use of a heated evaporator for the sample, i.e., as a non-treatment zone. The Petri dish was collected after 14 days. The ventilation rate was set at 0.5 times / hour.

[0302] (5) The collected petri dishes were washed, and the number of larvae and eggs of the dust mite was counted using a stereo microscope (manufactured by Olympus Corporation). The total number of eggs laid was defined as the total number of eggs laid.

[0303] (6) Repeat the above (2) to (5) twice and calculate the average number of total eggs laid. Also calculate the average number of total eggs laid after 14 days in the untreated control group and calculate the egg laying inhibition rate using the following formula (VI).

[0304] Formula (VI): Egg laying inhibition rate (%) = [{(average of total egg laying in the untreated area) - (average of total egg laying when the heating evaporator is set)} / (average of total egg laying in the untreated area)] × 100

[0305] [Table 17]

[0306] Table 17

[0307]

[0308] The above results confirm that the egg laying, or proliferation, of mites is significantly suppressed by using the heated evaporator using Sample 15. Thus, by maintaining the concentration of the pyrethroid compound in the air within a specific range, the proliferation of creeping pests can be suppressed.

[0309] In addition to the above, the same evaluation of stopping and preventing the creeping pests, Dermatophagoides farinae, as that of cockroaches was conducted, and it was confirmed that the stopping and preventing effect was achieved.

[0310] The present invention is described in detail with reference to specific embodiments, but it is obvious to those skilled in the art that various changes and modifications can be made without departing from the spirit and scope of the present invention. This application is based on Japanese patent applications (Japanese Patent Application No. 2023-013304) filed on January 31, 2023 and Japanese patent applications (Japanese Patent Application No. 2023-078173) filed on May 10, 2023, and their contents are incorporated herein by reference.

[0311] Description of Reference Numerals

[0312] 10 partition

[0313] 11 Heating Evaporative Agent

[0314] 12 Shelter

[0315] 13 Water

[0316] 14 solid bait

[0317] 20 opening

Claims

1. A method for controlling creeping pests, which comprises volatilizing a control composition containing a pyrethroid compound, wherein: By volatilizing the control composition into the space, the concentration of the pyrethroid compound in the air in the space is maintained at 1 μg / m 3 ~100 μg / m 3 within a range of , preventing creeping pests from settling in the space.

2. A method for controlling creeping pests, which comprises heating and evaporating a control composition containing a pyrethroid compound, characterized in that: The control composition is heated and evaporated into the space, and the concentration of the pyrethroid compound in the gas in the space is maintained at 1 μg / m 3 ~100 μg / m 3 within a range of , preventing creeping pests from settling in the space.

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