Ejector with improved piercing tip

Abstract

The present invention relates to various types of dispensers wherein these dispensers are each configured to apply a fluid (F) at the nasal cavity of a patient wherein the dispensers are filled with the fluid (F) wherein the fluid comprises lipid nanoparticles. The invention further relates to a method of assembling such a dispenser and to the use of such a dispenser.

Description

Technical Field

[0001] The present disclosure relates to an emitter for discharging a predetermined amount of fluid and a discharge system comprising such an emitter, as well as a corresponding method of using such an emitter. The present disclosure further relates to the use of the emitter and the discharge system for discharging a fluid comprising at least one pharmaceutical, dental or veterinary agent. Background Art

[0002] Dispensers such as disposable syringes for use in the medical, dental or veterinary fields are generally known and comprise one or more compartments in which a medical, dental or veterinary agent or a liquid comprising a medical, dental or veterinary agent is contained prior to use. The compartments are typically sealed with various types of shielding foils to isolate their contents from the environment.

[0003] Typically, these dispensers are used to treat a patient's symptoms. Summary of the Invention

[0004] The object of the present invention is to provide a dispenser with the help of which not only symptoms can be treated, but also infections can be avoided and preferably prevented by using the dispenser.

[0005] A further object of the present invention is to provide a dispenser which is low in cost and simple to use.

[0006] These objects are met by an emitter having the features of the respective independent claim.

[0007] The emitter is configured to apply a fluid at and / or in a nasal cavity of a patient, wherein the emitter is filled with the fluid, wherein the fluid includes lipid nanoparticles.

[0008] The present invention further relates to the use of a drain configured to apply a fluid at a nasal cavity of a patient, wherein the drain is filled with the fluid, wherein the fluid comprises lipid nanoparticles, and the fluid is applied at and / or in the nasal cavity.

[0009] By using such a dispenser, a fundamental improvement in the prophylactic and therapeutic protection against human infections, such as due to influenza (flu) or cold viruses, is provided.

[0010] This makes possible a first-in-class, potent immunotherapy based on optimized antibodies contained in newly developed lipid nanoparticles (LNPs) and delivered to the nasal cavity, leading to a reduction in the number of infections with viral pathogens.

[0011] Such an emitter comprises a dispensing element and a housing having a static piston connected to the dispensing element in at least a fluid-conducting manner, and wherein the static piston is arranged within the housing; the emitter further comprises a container containing a fluid, the container being movable relative to the static piston and the housing, wherein the static piston comprises a piercing tip adapted to pierce a membrane or a seal of the container when the container is moved toward the housing, wherein the static piston further comprises at least one sealing element arranged in the region of the piercing tip, wherein when the movable container is moved relative to the housing into a position in which the membrane or the seal is pierced and in which the at least one sealing element engages an inner surface of the container, the at least one sealing element provides a seal between the piercing tip and the inner surface to prevent fluid from passing between the at least one sealing element and the inner surface and into a portion of the housing.

[0012] The at least one sealing element thereby provides a direct seal between the static piston and the container, thereby ensuring that no fluid can pass between the at least one sealing element and the inner surface of the container, and thereby preferably preventing fluid from leaking from the container into a portion of the housing that is not configured to receive fluid.

[0013] In contrast to designs in which the housing is sealed against the outside, the present invention therefore seals directly between the parts of the ejector that are most likely to leak and that are movable relative to each other.

[0014] Furthermore, by providing a seal engaging the inner wall of the container, the container is more accurately aligned relative to the housing and hence relative to the discharger, as the seal acts as an additional guide for the container. Thus, such an assembly can also advantageously compensate for incorrect installation of the container at the discharger.

[0015] Preferably, the at least one sealing element is arranged at the end of the puncture tip that is remote from the other end of the puncture tip comprising the inlet of the dispensing element. When the container is brought towards the static piston, the membrane or seal of the container then comes into contact with the end of the puncture tip comprising the inlet, so that the fluid is first dispensed from the container via the dispensing element.

[0016] Advantageously, the membrane or seal is configured to be pierced by the other end of the piercing tip comprising the inlet. Preferably, the membrane or seal is then first pierced in the region of the inlet so that the fluid stored in the container, which is then pressurized, can pass directly into the inlet and thereby into the dispensing element.

[0017] Particularly preferably, the at least one sealing element is a sealing lip. A sealing lip is simple and cost-effective to produce and ensures a good seal between two components that are movable relative to one another.

[0018] Preferably, first, second and preferably third sealing lips are provided, all of which are configured to engage the inner surface to prevent fluid from passing into said portion of the housing. Advantageously, the first, second and preferably third sealing lips are arranged successively parallel to each other along the longitudinal axis of the discharger.

[0019] The provision of at least two sealing lips arranged to engage the inner surface on the one hand increases the sealing action in this area of ​​the discharger. On the other hand, this double sealing arrangement arranged one after the other and parallel to one another further improves the guidance of the container relative to the housing, thereby further correcting any initially existing misalignment between the housing and the container.

[0020] Preferably, the diameter of the first sealing element is smaller than the diameter of the second sealing element, and if a third sealing element is provided, the diameter of the first sealing element is smaller than the diameter of the third sealing element, wherein the second and third sealing elements preferably have at least substantially the same diameter. Forming the first sealing element such that its diameter is smaller than the diameter of the second or even third sealing element means that the first sealing element can be pushed into the compartment and towards the inner surface after the membrane or seal has been pierced, clearing the way for the subsequent sealing element which then fully engages the inner surface of the container.

[0021] In this regard, it is advantageous if the outer diameter of the first sealing element is smaller than or equal to the inner diameter of the container, and the outer diameter of the second sealing element and optionally the third sealing element is larger than the inner diameter of the container. This facilitates the introduction of the static piston into the container during the discharge process and ensures an improved seal between the inner surface of the container and the second and third sealing elements.

[0022] Preferably, the diameter of the puncture tip decreases from the at least one sealing element to the other end of the puncture tip, which includes the inlet. On the one hand, if the container is misaligned relative to the housing, the shape of the puncture tip allows for correction of this misalignment. On the other hand, the shape of the puncture tip allows for the application of preferably uniform pressure on the membrane or seal, causing it to be pierced, preferably centrally, by the puncture tip. Central puncture of the membrane or seal ensures that the seal is pierced in the region of the inlet. This further prevents fluid from flowing down the puncture tip and toward the at least one sealing element.

[0023] In this connection, it should be noted that the compartment advantageously comprises an end (in particular a puncture tip receiving end) which is arranged opposite the membrane or the seal and is configured to complement or at least substantially complement the shape of the puncture tip. This ensures that as much as possible of the volume of fluid stored in the compartment has been discharged by the dispensing element in the post-discharge state of the discharger, once the puncture tip has completely passed through the space of the compartment and has reached the end of the compartment.

[0024] Preferably, the container comprises a compartment in its interior in which the fluid is initially stored before the membrane or seal is pierced, and wherein the inner surface is present at the wall of the compartment. In this way, the at least one sealing element provides a direct seal in the region of the parts of the ejector that are movable relative to each other and therefore susceptible to leakage.

[0025] Advantageously, the container further comprises an outer wall arranged parallel to the wall of the compartment and a guide groove present between the outer wall and the wall of the compartment, wherein the guide groove receives at least a portion of the housing. This preferably annular groove ensures that the container can be correctly aligned relative to the housing when assembling the discharger, thereby avoiding misalignment of these parts when assembling the discharger.

[0026] Preferably, the ejector comprises a child safety lock, in particular wherein the child safety lock is formed between the container and the housing. Such a child safety lock prevents accidental activation of the ejector.

[0027] Advantageously, in the discharger's storage state, the at least one sealing element does not contact the housing, and in the discharge or post-discharge state of the discharger, the at least one sealing element contacts only the inner surface of the container. In this manner, an discharger is formed in which, in the discharger's storage state, no forces act on the at least one sealing element. Such forces could cause the at least one sealing element to degrade over time, thereby reducing the sealing effect in this area during use of the discharger.

[0028] Preferably, the inner surface of the cylindrical wall of the housing includes a further inwardly projecting sealing lip configured to engage a surface of the container that is different from the inner surface. If fluid does pass between the at least one sealing element and the inner surface of the compartment into a portion of the housing, the further sealing element can prevent the fluid from escaping between the housing and the container if the user places their hand against the further sealing element during discharge. This means that, at least during discharge, the user does not come into direct contact with the fluid present in the discharger.

[0029] Advantageously, the emitter is filled with a fluid selected from the group consisting of topical medications, medical fluids, cosmetic and / or skin care formulations, dental fluids, veterinary fluids, adhesive fluids, disinfectant fluids, and combinations thereof.

[0030] In this way, for example, tooth whiteners, tooth fluorides, disinfectants, adhesives, wound adhesives, local anesthetics, sunscreens, after-sun repairs, skin moisturizers, or other pharmaceuticals and cosmetics can be stored in the dispenser and administered using the dispenser. Such fluids can be, for example, the aforementioned Frontline, eye drops, and nasal drops, which are used, for example, to relieve blocked eyes and noses in patients suffering from allergies, colds, or the flu.

[0031] In a further aspect, the present invention relates to a static piston for an ejector, wherein the static piston is preferably configured for use with the ejector discussed above, wherein the static piston comprises a piercing tip having an inlet formed at an end thereof and a passage starting from the inlet and passing through the piercing tip and through the static piston to an outlet, wherein the static piston comprises at least one sealing element formed at an end of the piercing tip remote from the inlet.

[0032] The advantages associated with the discharger according to the invention also apply to the static piston described herein.

[0033] In yet another aspect, the present invention relates to a method of discharging a fluid from an emitter, in particular an emitter according to the foregoing discussion, the method comprising the steps of:

[0034] - guiding the container in a direction along the longitudinal axis of the ejector towards a piercing tip of a static piston housed in the housing of the ejector,

[0035] - piercing, preferably uniformly piercing, a membrane or a seal present at the container by means of the piercing tip, thereby causing the membrane or the seal to be pierced, in particular initially in the center of the membrane or the seal,

[0036] - further directing the container toward the static piston and engaging an inner surface of the container with at least one sealing element arranged at the piercing tip of the static piston to prevent fluid from passing between the at least one sealing element and the inner surface and thereby into a portion of the housing, and

[0037] - Discharge the fluid via the outlet of the drain.

[0038] The advantages associated with the emitter according to the invention also apply to the method described herein.

[0039] Such a container for a manually operated discharger comprises a compartment for a fluid, and a longitudinal axis, wherein the compartment is constructed to be: on the one hand sealed and isolated by at least one wall of the compartment, the at least one wall extending peripherally around the longitudinal axis at least regionally; and on the other hand sealed and isolated by a seal at the front end of the container, wherein the container is a double-walled container, which, in addition to the walls of the compartment, further comprises an outer wall extending around the walls of the compartment, wherein a groove is formed between the outer wall and the walls of the compartment, and wherein at least one connecting web preferably fixedly connects the outer wall to the wall of the compartment.

[0040] The grooves are provided on the double-walled container as installation guides. This prevents the container from being installed skewed on the drain housing. Furthermore, during use of the drain, the grooves function as guide grooves. This is because, when the container is installed on the drain, the drain housing can be guided relative to the container in the grooves. This ensures that the container is reliably guided relative to the puncture tip disposed therein. Specifically, it has been found that if the container is guided as evenly as possible relative to the drain housing, leakage of liquid from the container into a portion of the drain housing or outside the drain housing can be significantly reduced, and possibly even prevented.

[0041] By providing an outer wall surrounding the wall of the compartment and connecting the two walls by means of at least one connecting web, such a double-walled container is provided in a cost-effective manner.

[0042] The seal of the container is preferably configured to be pierced during use of the container. Forming the seal so that it can be pierced provides a predefined outlet to the container via which the fluid stored in the compartment can be removed from the container.

[0043] Preferably, the walls of the compartment and the outer wall of the preferably cylindrical container are injection molded in one piece from the same material. The use of an injection molding process provides a reproducible and cost-effective manufacturing method for the plastic parts. Since the connecting web is preferably also formed during the injection molding process, it is automatically formed integrally with the walls of the compartment and the outer wall of the container and is thus fixedly connected to the walls of the compartment and the outer wall of the container.

[0044] Advantageously, the length of the groove is at least 50%, preferably 70% to 95% of the length of the outer wall in the direction of the longitudinal axis of the container. In this way, the groove of the container is configured to receive the majority of the housing, thereby ensuring guidance of the container relative to the majority of the housing.

[0045] It should be noted that the groove is open at the front end. In this way, the components of the container that are configured to interact with the housing are arranged at one side of the container.

[0046] Preferably, the front end coincides with a plane comprising at least one of the ends of the compartment walls, the ends of the outer walls, the seal and the opening of the groove. This means that the components of the container forming the front end are all arranged at substantially the same height of the container.

[0047] Advantageously, the rear end of the container includes a recess formed therein, preferably wherein the recess is configured for placing a user's finger or thumb. Thus, the rear end is configured to improve placement of a user's thumb or finger using a dispenser having such a container.

[0048] Preferably, the end of the compartment located opposite the front end is formed by a further wall of the compartment, wherein the further wall converges from the walls of the compartment to a common point forming the end of the compartment, said common point preferably coinciding with the longitudinal axis.

[0049] The end of the compartment is formed so that it converges to a common point, which means that it is configured to complement or at least substantially complement the shape of the piercing tip of the drain. When the drain is in use, the piercing tip passes completely through the space of the compartment and, when it reaches the end of the compartment, ensures that as much of the volume of fluid stored in the compartment as possible has been drained from the drain.

[0050] Advantageously, the end of the compartment is set back from the rear end of the container by at least 20%, in particular 25% to 45% of the length of the outer wall. This design has advantages in terms of manufacturing tolerances when injection molding the container, because fewer delicate parts need to be provided at the rear end of the container than at the front end of the container.

[0051] Preferably, an additional web is provided, extending parallel to the outer wall between the end of the compartment and the rear end of the container, wherein the additional web particularly forms the base of the recess. By means of the additional web, when the container is mounted on the housing of the discharger, pressure exerted on the rear end of the container can be converted into a movement in the direction of the longitudinal axis of the container. In this regard, it should be noted that, when the container is mounted on the housing of the discharger, the longitudinal axis of the container coincides with the longitudinal axis of the discharger.

[0052] Advantageously, the walls of the compartment extend parallel to the outer wall beyond the end of the compartment.This design has advantages in terms of manufacturing tolerances when injection moulding the container, as fewer delicate parts need to be provided at the rear end of the container.

[0053] Preferably, at least one slot is formed in the outer wall, wherein the slot extends from the recess to the outer surface of the outer wall.If the discharger cooperating with the housing comprises a pin or the like, the guidance of the container relative to the housing can be further improved by means of such a complementary part.

[0054] Advantageously, the at least one groove comprises two longitudinal sections which are parallel to each other and offset relative to the longitudinal axis and which are connected to each other via a connecting section. This design can then be used, for example, to form a childproof lock and / or to clearly define the storage state of a drainer comprising such a container relative to its discharge or post-discharge state.

[0055] In a preferred embodiment, the container is filled with a fluid. In this case, a substance (such as frontline) can be easily stored in the container. In this regard, it should be noted that the container is advantageously sealed by a seal, preferably configured as a membrane. A membrane is an advantageous type of seal that, after puncture, allows the container to interact correctly with the ejector.

[0056] The container is preferably filled with a fluid selected from the group consisting of topical medications, medical fluids, cosmetic and / or skin care formulations, dental fluids, veterinary fluids, adhesive fluids, disinfectant fluids, and combinations of the foregoing.

[0057] In this way, for example, tooth whiteners, tooth fluorides, disinfectants, adhesives, wound adhesives, local anesthetics, sunscreens, after-sun repairs, skin moisturizers, or other pharmaceuticals and cosmetics can be stored in the dispenser and administered using the dispenser. Such fluids can be, for example, the aforementioned Frontline, eye drops, and nasal drops, which are used, for example, to relieve blocked eyes and noses in patients suffering from allergies, colds, or the flu.

[0058] In a further aspect, the present invention relates to an ejector comprising a container as described herein. The ejector further comprises a housing and a static piston, wherein the container is configured to move relative to the housing and the static piston between a storage state, a discharge state, and a post-discharge state, wherein at least some portion of the housing is received in the recess in the storage state, the discharge state, and the post-discharge state, and wherein the recess is preferably configured to receive a cylindrical wall of the housing and permit movement of the cylindrical wall therein to guide the container relative to the housing, and in particular wherein the recess is configured to receive the housing to a greater extent in the discharge state than in the storage state, and in particular to receive the housing to a greater extent in the post-discharge state than in the discharge state.

[0059] The advantages described in connection with the container also apply with respect to the discharger described in this document.

[0060] Improved guidance is brought about in particular by forming the width of the guide groove slightly wider than the thickness of the shell in such a way that the shell can be movably received in the guide groove with sufficient clearance for movement, but the clearance is not so great that there is a clearance between the shell and the container, allowing these components to become deflected relative to each other.

[0061] Preferably, the static piston includes at least one sealing element configured to engage an inner surface of the compartment when the discharger is in one of the discharge state and the post-discharge state.

[0062] The at least one sealing element thereby provides a direct seal between the static piston and the compartment of the container, thereby ensuring that no fluid can pass between the at least one sealing element and the inner surface of the compartment, and thereby preferably preventing fluid from leaking from the container into a portion of the housing that is not configured to receive fluid during either the discharge or post-discharge state.

[0063] Advantageously, the housing includes a sealing element at an inner surface thereof, the sealing element being configured to engage an outer surface of the compartment when the discharger is in one of the discharge state and the post-discharge state.

[0064] If fluid does pass between the at least one sealing element and the inner surface of the compartment into a portion of the housing, the further sealing element can prevent the fluid from escaping between the housing and the container where the user places his / her hand during discharge. This means that, at least during discharge, the user does not come into direct contact with the fluid present in the discharger.

[0065] In a further aspect, the present invention relates to a method of assembling an emitter as described herein, the method comprising the steps of:

[0066] - introducing at least a portion of the housing into the recess of the container, and

[0067] - Axially displacing the container relative to the housing in the direction of the longitudinal axis.The advantages associated with the discharger according to the invention also apply to the method described herein.

[0068] Advantageously, the method comprises the further steps of: subsequently rotating the container; and activating a childproof lock when the container is rotated to reach the storage position of the ejector. Such a childproof lock prevents accidental activation of the ejector.

[0069] Such an ejector comprises a dispensing element and a housing having a static piston which is connected at least in a fluid-conducting manner to the dispensing element, wherein the static piston has a piercing tip and is arranged in the housing; the ejector is configured to receive at least a portion of a container for containing a fluid, wherein the container is then movable relative to the static piston and the housing in a longitudinal direction of the ejector, wherein the housing comprises a sealing element which is arranged at an inner surface of the housing, wherein the sealing element protrudes from the inner surface of the housing in the direction of the longitudinal direction of the ejector.

[0070] During use of the discharger, a sealing element disposed on the inner surface of the housing is configured to engage the surface of the container, particularly when the discharger is in one of the discharge and post-discharge states. This sealing element is provided to prevent fluid from escaping between the housing and the container. This is the area of ​​the discharger where the user places their hand during discharge. This means that, at least during discharge, the user does not come into direct contact with the fluid in the discharger, as leakage in this area is prevented by the sealing element located on the inner surface of the housing.

[0071] Thus, the present invention seals directly between the parts of the emitter that are most likely to leak and that are movable relative to each other. This is achieved in a cost-effective manner by providing the seal at the inner surface of the housing.

[0072] Preferably, the housing has a cylindrical wall with an inner surface, and the sealing element is arranged to extend circumferentially around the inner surface of the cylindrical wall. Cylindrical housings are simple to manufacture, for example in an injection molding process. Providing a sealing element that extends around the entire inner surface of such a housing means that an effective seal is formed without interruption.

[0073] Furthermore, the round portions can be aligned accurately relative to one another, thereby permitting simple mounting of the container at the housing of the discharger.Thus, this design of the housing can also advantageously facilitate mounting of the container at the discharger.

[0074] Preferably, the sealing element is arranged on the inner surface of the housing in the region of the puncture tip. When the ejector is in use, the forces arising during the puncture action of the seal cause the fluid stored in the container to leak out in the region of the puncture tip. Therefore, providing the sealing element in the region of the puncture element means that it is placed near the portion of the housing where leakage is most likely to occur.

[0075] Particularly preferably, the sealing element is an inwardly protruding sealing lip. The sealing lip is simple and cost-effective to produce and ensures a good seal between two components that are movable relative to each other.

[0076] Advantageously, the sealing element projects in the direction of the puncture tip arranged along the longitudinal direction. In this way, the sealing element is arranged in the direct vicinity of the portion of the housing where leakage is most likely to occur.

[0077] Preferably, the sealing element is arranged in a plane perpendicular to the longitudinal direction, wherein the plane further comprises at least one of the puncture tip, the end of the puncture tip and the inlet of the puncture tip.It has been found that such a design produces particularly good sealing results.

[0078] Preferably, the sealing element is either integrally formed on the inner surface of the cylindrical wall or contacts the inner surface of the cylindrical wall. An integrally formed sealing element is simple to manufacture, for example during the injection molding process, and ensures close contact of the sealing element on the housing. A separate sealing element, such as an O-ring, can also be used in a simple and cost-effective manner.

[0079] Advantageously, the discharger further includes a container, wherein the sealing element contacts or is connected to the housing only in the storage state of the discharger, i.e., the container does not contact the sealing element in the storage state; and wherein the sealing element is configured to engage the container in at least one of the discharge state and the post-discharge state of the discharger, in addition to being in contact or connected to the housing in both the discharge state and the post-discharge state of the discharger. In this manner, a discharger is formed in which forces only act on the sealing element when the discharger has been displaced from the storage state to one of the discharge state and the post-discharge state of the discharger. Such forces may cause the at least one sealing element to degrade over time, thereby reducing the sealing effect in this area when the discharger is in one of the discharge state and the post-discharge state.

[0080] Preferably, the container comprises a seal, wherein the piercing tip is configured to pierce the seal of the container when the container is removed from the storage state and moved towards the housing, and in particular wherein the sealing element is configured to engage the container, preferably a surface of the container, as soon as the seal of the container comes into contact with the piercing tip.

[0081] When a seal is used, the container can be used to store fluid. By allowing the seal to open only upon activation of the drain, the fluid stored therein is not exposed to the surrounding atmosphere prior to activation of the drain. Furthermore, by positioning the sealing element within the housing so that it contacts the container only upon puncture of the seal, no force is exerted on the sealing element prior to activation of the drain, thereby ensuring that the sealing element does not degrade during storage of the drain.

[0082] Advantageously, the static piston comprises at least one further sealing element arranged at the piercing tip.Such an additional sealing element further improves the tightness of the discharger.

[0083] Preferably, the at least one further sealing element provides a seal between the piercing tip and an inner surface of the container when the movable container is moved relative to the housing into a position in which the seal is pierced, wherein the inner surface is different from a surface of the container.

[0084] The at least one further sealing element of the static piston thereby provides a direct seal between the static piston and the container, thereby ensuring that no fluid can pass between the at least one sealing element and the inner surface of the container, and thereby preferably preventing fluid from leaking from the container into a portion of the housing that is not configured to receive fluid during either the discharge or post-discharge state.

[0085] In this connection it should be noted that the at least one further sealing element can also be a sealing lip. A sealing lip is simple and cost-effective to produce and ensures a good seal between two components that are movable relative to one another.

[0086] Preferably, the container comprises a compartment in its interior in which the fluid is initially stored before the seal is pierced, and wherein the surface engaged by the sealing element of the housing is an outer surface of a wall of the compartment.

[0087] Advantageously, the container further comprises an outer wall arranged parallel to the wall of the compartment and a guide groove present between the outer wall and the wall of the compartment, wherein the guide groove is configured to receive at least a certain portion of the housing.

[0088] The guide grooves are provided on the double-walled container as installation guides. This prevents the container from being installed crookedly on the discharger housing. Furthermore, during use of the discharger, the grooves function as guide grooves. This is because when the container is installed on the discharger, the housing can be guided relative to the container in the grooves.

[0089] Preferably, the drain includes a child safety lock. Such a child safety lock prevents accidental activation of the drain.

[0090] Preferably, in the storage state of the discharger, the fluid is stored in the container. In this case, substances (such as Frontline) can be easily stored in the container. In this regard, it should be noted that the container is advantageously sealed and isolated by a seal, which is preferably configured as a membrane. A membrane is an advantageous type of seal that, after puncture, allows the container to interact correctly with the discharger.

[0091] Advantageously, the emitter is filled with a fluid selected from the group consisting of topical medications, medical fluids, cosmetic and / or skin care formulations, dental fluids, veterinary fluids, adhesive fluids, disinfectant fluids, and combinations thereof.

[0092] In this way, for example, tooth whiteners, tooth fluorides, disinfectants, adhesives, wound adhesives, local anesthetics, sunscreens, after-sun repairs, skin moisturizers, or other pharmaceuticals and cosmetics can be stored in the dispenser and administered using the dispenser. Such fluids can be, for example, the aforementioned Frontline, eye drops, and nasal drops, which are used, for example, to relieve blocked eyes and noses in patients suffering from allergies, colds, or the flu.

[0093] In a further aspect, the present invention relates to a method of discharging a fluid from an emitter, in particular an emitter as discussed above, the method comprising the steps of:

[0094] - guiding the container in the longitudinal direction of the ejector towards the piercing tip of a static piston housed in the housing of the ejector,

[0095] - piercing a membrane or a seal present at the container by means of a piercing tip, thereby causing the seal to be pierced, in particular initially in the center of the seal,

[0096] - engaging an outer surface of the container with at least one sealing element arranged at the inner surface of the housing to prevent the passage of fluid between the at least one sealing element and the outer surface, and preferably

[0097] - guiding the container further towards the static piston to discharge the fluid via the outlet of the discharger.

[0098] The advantages associated with the emitter according to the invention also apply to the method described herein.

[0099] According to the present invention, a discharger for discharging a predetermined amount of fluid comprises:

[0100] - a housing defining a longitudinal first axis and having a proximal end and a distal end,

[0101] a discharge section having a discharge passage for the fluid extending between an inlet opening and an outlet opening of the discharge section,

[0102] a bracket cooperating with the proximal region of the housing such that the bracket is movable relative to the housing along a first axis, the bracket comprising a receiving space for the fluid, and

[0103] a piercing tip, which is separate from the carrier and has a flow channel for establishing a flow connection for the fluid from the receiving space of the carrier to the inlet opening of the discharge section, the piercing tip defining a centrally extending second longitudinal axis and having a shell surface, wherein the shell surface of the piercing tip has a substantially convexly curved configuration, in particular a dome-shaped configuration.

[0104] Generally speaking, the discharger may be suitable for use in the medical, dental, or veterinary fields, or in the healthcare industry. The fluid to be discharged is, in particular, a liquid comprising at least one medical, dental, or veterinary agent. However, the present disclosure is not limited to the medical, dental, or veterinary industries, but may be used in other apparatuses where it is desired to discharge a predetermined amount of fluid in a reliable and uniform manner.

[0105] The present disclosure is not limited to the discharge of fluids, such as liquids. Rather, the discharger as disclosed herein may alternatively be adapted or used to discharge viscous or gel-like materials.

[0106] In a preferred embodiment, the flow channel is centrally located within the piercing tip and extends along a longitudinal second axis defined by the piercing tip, thereby establishing a flow connection to the inlet opening of the discharge section.

[0107] The flow channel can also be located at an offset position relative to the second longitudinal axis. In this case, the flow channel can, for example, extend obliquely relative to the second axis. The flow channel can also be divided into different axially and radially extending sections. For example, the flow channel can be divided into a first axial section that extends offset from the second axis and merges into a radial section, which in turn merges into a second axial section that extends offset from or along the second axis, thereby establishing a flow connection to the inlet opening.

[0108] The flow channel can be cylindrical and preferably has a diameter between 1 / 20 and 1 / 5, more preferably between 1 / 15 and 1 / 7, and particularly between 1 / 11 and 1 / 9 of the diameter of the puncture tip at its widest point. Generally, this widest point corresponds to the point where the puncture tip begins to taper. However, the flow channel can also have an oval, triangular, or rectangular cross-section, for example.

[0109] The flow channel is defined by an orifice at the shell surface of the puncture tip, i.e., the orifice represents an interruption of the shell surface. Unless otherwise stated, the orifice should not be considered in detail within the scope of the following discussion of the configuration or shape of the puncture tip. This means that, unless otherwise stated, the discussion should generally be based on an imaginary closed shell surface of the puncture tip.

[0110] According to the present invention, the outer surface of the puncture tip is convexly curved or arched relative to the exterior. In other words, the shell surface of the puncture tip includes at least an outer surface section having a convexly curved configuration. This means that the puncture tip may also include at least one surface section that is not convexly curved but, for example, conical or frustoconical. However, according to the present invention, the shell surface of the puncture tip has a substantially convexly curved configuration. More preferably, the puncture tip has a substantially dome-shaped configuration. In this context, the term "substantially" means that the main configuration of the puncture tip (i.e., the main portion of the shell surface of the puncture tip) is convexly curved or dome-shaped, respectively, but there may be small areas (particularly in the area where the orifice of the flow channel is located) where the configuration may slightly deviate from a convexly curved or dome-shaped configuration. Of course, it is also possible that the shell surface of the puncture tip has a completely convexly curved or dome-shaped configuration.

[0111] In a preferred embodiment, the puncture tip is substantially rotationally symmetrical about a centrally extending second longitudinal axis defined by the puncture tip. In this context, it is particularly preferred that the second longitudinal axis corresponds to a first longitudinal axis defined by the housing of the ejector, i.e., the puncture tip is also preferably substantially rotationally symmetrical about the first longitudinal axis. In this context, the term "substantially" also implies that the puncture tip (particularly in the region where the orifice of the flow channel is located) may deviate slightly from a rotationally symmetrical configuration.

[0112] Surprisingly, the results show that puncture tips with a convexly curved outer surface, in particular those that are essentially rotationally symmetrical, are particularly well-suited not only for reliably piercing a wide variety of shielding foils, but also for a consistent and uniform discharge process. The reason for this is that the puncture tip according to the present invention combines two features. On the one hand, only a relatively moderate and user-friendly puncture force is required to initially pierce the foil. On the other hand, particularly due to its convexly curved configuration, the force that must be applied during the displacement of the puncture tip (i.e., during the discharge process) remains essentially constant over a wide distance. This ensures a highly uniform discharge, as the user only needs to apply a substantially constant and moderate force during the discharge process.

[0113] The shape of the substantially rotationally symmetrical puncture tip may be defined by two surface lines of a longitudinal section along the second axis. The point where the two surface lines intersect may be referred to as the apex or tip of the puncture tip.

[0114] In an embodiment having a substantially rotationally symmetrical puncture tip, the two surface lines are substantially axially symmetrical with respect to the longitudinal second axis. In this case, the configuration of the two surface lines is substantially independent of the relative position of the longitudinal sections along the second axis. This means that the two surface lines obtained from a first longitudinal section along the second axis have substantially the same configuration as the two surface lines obtained from a second longitudinal section along the second axis that is rotated, for example, 90° relative to the first longitudinal section. As mentioned above, the term "substantially" implies that the surface lines (particularly in the region where the orifice of the flow channel is located) may deviate slightly from an axially symmetrical configuration.

[0115] In embodiments having a flow channel centrally located along the longitudinal second axis, the apex of the puncture tip may be an imaginary point located where two surface lines would intersect if they were not interrupted by the flow channel.

[0116] Generally speaking, each of the two surface lines can be divided into two or more different segments with different characteristics. For example, the surface line can be divided into a linear segment and a curved segment, where the curved segment can be a segment of a circle, an ellipse, or a parabola. The curved segment of the surface line corresponds to the convexly curved outer surface segment of the puncture tip. According to another example, the surface line can be divided into a segment that is a segment of a circle and a segment that is a segment of a parabola or an ellipse. According to yet another example, the surface line can be divided into different segments, where each segment represents a segment of a circle with a different diameter.

[0117] In an embodiment, the two surface lines of the longitudinal section along the second axis intersect at an angle of between 70° and 110°, preferably between 80° and 100°, more preferably between 85° and 95°, in particular approximately 90°.

[0118] According to this embodiment, each of the two surface lines can be divided into at least two different segments: a linear segment forming the apex of the puncture tip and at least one further curved segment representing the convexly curved outer surface segment of the puncture tip. This means that the outer surface segment of the puncture tip is divided into a conical segment forming the apex and at least one further convexly curved surface segment. Preferably, the conical segment is considerably smaller than the convexly curved surface segment.

[0119] In a further embodiment, the shape of the puncture tip in a longitudinal cross-section along the second axis is defined by two surface lines, each surface line having at least one segment defined by a radius of curvature greater than the diameter of the puncture tip at its widest point. According to this embodiment, each of the two surface lines includes at least one segment that is a segment of a circle having a radius greater than the diameter of the puncture tip at its widest point.

[0120] Advantageously, this section represents the largest part of the surface line, wherein it is particularly preferred that the surface line comprises only one further section, preferably with a radius of curvature of smaller diameter.

[0121] The radius of curvature that is greater than the diameter of the puncture tip at its widest point may have a length between 1.01 and 1.50 times, preferably between 1.05 and 1.40 times, more preferably between 1.10 and 1.30 times, in particular approximately 1.20 times the diameter of the puncture tip at its widest point.

[0122] In yet another embodiment, the puncture tip is defined by two surface lines in a longitudinal section along the second axis, each surface line having at least two segments with different radii of curvature. According to this embodiment, each of the two surface lines includes at least two segments, each segment being a section of a circle with a different radius.

[0123] Preferably, the radius of curvature of the first section (i.e., the section starting at the point where the puncture tip begins to taper) is smaller than the radius of curvature of the second section (i.e., the section following the first section). The length of the radius of curvature of the first section is preferably in the range of between one-tenth and one-half the radius of curvature of the second section.

[0124] The piercing tip according to another embodiment of the ejector may comprise a ridge at its apex, wherein the ridge is preferably perpendicular to the longitudinal second axis. However, the ridge may also be inclined or skewed relative to the longitudinal second axis.

[0125] The length of the ridge is preferably between 0.05 and 0.4 times, preferably between 0.1 and 0.35 times, more preferably between 0.15 and 0.3 times the diameter of the piercing tip at its widest point.

[0126] Even without taking the flow channel into account, the shape of the puncture tip having a ridge at its apex deviates at least slightly from a rotationally symmetrical configuration. This becomes particularly apparent when considering a first longitudinal section along the second axis and along the ridge, and a second longitudinal section rotated 90° relative to the first longitudinal section.

[0127] The properties of the surface line defining the puncture tip in the first section are largely the same as outlined above for the substantially rotationally symmetrical embodiment. However, instead of a vertex, the puncture tip has a ridge-like elevation, which is preferably located at an imaginary vertex of the puncture tip. This imaginary vertex is located at the point where the two surface lines would intersect if they were not interrupted by the ridge.

[0128] With respect to a second longitudinal section rotated 90° relative to the first longitudinal section, i.e., the plane of the second section is perpendicular to the spine, the shape of the puncture tip can preferably be described by two surface lines that intersect at an angle of between 70° and 110°, preferably between 80° and 100°, more preferably between 85° and 95°, in particular approximately 90°. This means that each of the two surface lines is divided into a linear segment corresponding to the lateral edge of the spine and at least one curved segment that can have the properties as previously outlined.

[0129] Advantageously, the ridge is interrupted by the flow channel so that two protrusions are formed adjacent to the flow channel. In other words, the flow channel divides the ridge into two separate ridge-like protrusions, which preferably have more or less the same size.

[0130] Advantageously, these protrusions reduce the piercing force that must initially be applied in order to pierce the shielding foil. In this way, a wide variety of shielding foils can be reliably pierced, and the ejector according to the invention can be applied substantially independently of the type of shielding foil used.

[0131] Advantageously, the ridges or protrusions adjacent to the flow channel are deformable, particularly when pressed against a counter-component, which preferably represents an end section of the receiving space. Due to their deformability, these protrusions are compressed when the puncture tip is pushed against the counter-component. This minimizes the space available for the fluid to be discharged between the puncture tip and the counter-component, which in turn reduces the amount of fluid residue at the end of the discharge process. This compression of the protrusions is achieved in such a way that the flow channel is not blocked by displaced material, fundamentally due to the shape and position of the protrusions.

[0132] The puncture tip is preferably at least partially positioned inside the housing so as to project into the receiving space of the bracket when the bracket moves toward the distal end of the housing. By means of the flow channel, the puncture tip thereby establishes a flow connection for the fluid to the inlet opening of the discharge section.

[0133] By providing a tray with a receiving space for the fluid, either a separate container suitable for loading into the receiving space and containing a predetermined amount of fluid can be loaded into the tray, or the predetermined amount of fluid to be discharged can be stored directly inside the receiving space. The amount of fluid contained either in the container or in the tray itself can be, for example, in the range of between 0.1 ml and 10 ml, preferably between 0.5 ml and 5 ml.

[0134] Advantageously, the fluid inside the receiving space or container is protected from environmental influences by a rupturable seal, in particular a shielding foil.

[0135] Preferably, a separate container is used to avoid storing the fluid directly within the receiving space of the tray. In this way, the tray can be reusable because it generally does not come into contact with the fluid to be discharged. Even if the tray or the entire drainer is a disposable product, providing a separate container containing the fluid can reduce storage costs for the drainer because the drainer and container can be stored independently.

[0136] In a preferred embodiment, the inner contour of the receiving space or the inner contour of the container is substantially complementary in shape to the puncture tip. In this context, the expression "substantially" implies that the shape of the inner contour in the region in which the orifice of the flow channel is located and (where applicable) in the region in which the protrusion is located can deviate from the exact complementary shape of the puncture tip.

[0137] This design allows for nearly complete drainage of the fluid, as the available space for the fluid can be completely filled by the piercing tip, resulting in nearly complete drainage of the fluid.

[0138] In this context, a substantially rotationally symmetrical piercing tip is particularly advantageous, since a specific orientation of the piercing tip relative to the complementary-shaped and therefore also rotationally symmetrical inner contour of the receiving space or container is not necessary to establish a positive connection. This also facilitates assembly of the ejector, since neither the piercing tip nor the complementary-shaped receiving space or container need adopt a preferred orientation.

[0139] In this regard, it should be noted that a piercing tip comprising two deformable protrusions can establish a form-fitting connection to the inner contour of a receiving space or a container, even if this inner contour is rotationally symmetrical and not specifically adapted to the protrusions. Due to the deformability of the protrusions, a piercing tip comprising deformable protrusions can adapt to the rotationally symmetrical inner contour of a receiving space or a container when a force is applied.

[0140] In this way, the advantages of a reduced initial force for piercing the shielding foil due to the protrusion at the piercing tip and a virtually residue-free discharge can be combined.

[0141] In a further embodiment, the puncture tip is formed integrally with the housing and / or the discharge section. In other words, it is preferred that the puncture tip and the housing and / or the discharge section are formed as one piece.

[0142] However, it may also be preferred that the piercing tip is formed as a one-piece separate piece, which can be linked to the housing and / or the discharge section, for example, by a plug connection.

[0143] Advantageously, the piercing tip is formed by injection moulding and preferably consists of an elastically deformable polymer selected from the group comprising polypropylene, cycloolefin polymers, polyethylene, polyamide, polybutylene terephthalate and polymethyl methacrylate.

[0144] Generally speaking, the discharger and / or container can be made of any suitable material. In one embodiment, the material is plastic, wherein the same polymers as named above are suitable. Alternatively, the material can be glass, metal or alloy.

[0145] In an embodiment, the drainer further comprises fixing means adapted to prevent the carriage from being unintentionally moved from the starting position along the longitudinal first axis.The fixing means facilitate handling of the drainer by avoiding unintentional manipulation of the carriage.

[0146] In particular, the securing device may include a pin / slot arrangement having at least one pin formed on the bracket and at least one slot formed in the wall of the housing. The pin is guided by the slot. The slot may include a first portion extending in a circumferential direction and merging into an axial slot portion extending along a first longitudinal axis of the discharger. This securing device requires the user to rotate the bracket relative to the housing before the bracket can be pushed into the housing and into its final discharge position.

[0147] Devices such as wing-like protrusions may be formed on the outside of the housing so that the ejector can be used like a conventional syringe, i.e., by placing one finger on each protrusion and the thumb on the proximal end of the holder or container loaded into the holder to hold the ejector, thereby providing comfortable one-handed operation of the ejector.

[0148] Another aspect of the present invention relates to a drain system comprising a drain as disclosed herein and at least one container containing a quantity of fluid to be drained, wherein the container is adapted to be loaded into a receiving space of a bracket of the drain.

[0149] A further aspect of the invention relates to the use of a drain as disclosed herein or a drain system as disclosed herein for draining a liquid comprising at least one pharmaceutical, dental or veterinary agent, wherein, in particular, the amount of liquid is in the range of 0.1 ml to 10 ml, preferably in the range of 0.5 ml to 5 ml.

[0150] With regard to a common classification for applications in the medical, dental or veterinary fields or in the healthcare industry, drains and drain systems as provided by the present disclosure belong to the group consisting of systems without protective caps.

[0151] Thus, one aspect of the present disclosure relates to a drain, comprising a housing defining a longitudinal axis and having a proximal end and a distal end, the drain comprising a drain device at least partially arranged inside the housing and having an inlet opening and an outlet opening located inside the housing, the drain device further defining a drain passage for a fluid extending between the inlet opening and the outlet opening, the drain comprising a carriage received in a proximal region of the housing and movable relative to the housing along the longitudinal axis between a starting position and a final drain position, wherein, in the starting position, the carriage protrudes from the proximal end of the housing so as to be pushable by a user further into the housing and toward the final drain position, and wherein the carriage defines a receiving space adapted to be loaded with a separate container containing a quantity of fluid to be drained, and the drain comprises activation means for establishing a flow connection for the fluid from within the receiving space of the carriage to the inlet opening of the drain device, the activation means being inoperative when the carriage is in the starting position and adapted to establish the flow connection when the carriage is in or moving toward the final drain position.

[0152] According to another aspect of the present disclosure, there is provided a container comprising a predetermined amount of fluid to be discharged by the discharger. According to a further aspect of the present disclosure, there is provided a discharge system comprising the discharger as disclosed herein and a container loaded or adapted to be loaded into a carriage of the discharger.

[0153] The discharger may be suitable for use in the medical, dental or veterinary fields or in the healthcare industry, wherein the fluid contained in the container is in particular a liquid comprising at least one medical, dental or veterinary agent. However, the present disclosure is not limited to the medical, dental or veterinary industries and may be used in other appliances where it is desired to discharge a predetermined amount of fluid in an easy and reliable manner and the fluid is well protected from environmental influences.

[0154] The present disclosure is not limited to the discharge of fluids, such as liquids. Rather, the discharger as disclosed herein may alternatively be adapted or used to discharge viscous materials.

[0155] The concept of the present disclosure avoids storing fluid directly within the drain itself. This achieves a virtually unlimited storage life for the drain. By providing a carrier with a receiving space, individual containers can be loaded into the drain. This concept allows for simple yet reliable, one-handed operation of the drain, as the drain's activation mechanism automatically establishes a fluid connection from a container loaded into the carrier's receiving space to the drain's inlet opening.

[0156] The amount of fluid included in the container may range between 0.2 ml and 2 ml. In an embodiment, the amount of fluid included in the container is 0.5 ml.

[0157] In one embodiment, the activation device establishes a fluid connection when the carriage is midway between the starting position and the final discharge position, allowing fluid to begin flowing through the discharge passageway before the carriage reaches its final discharge position. In alternative embodiments, the activation device may require the user to perform additional steps to actually establish the fluid connection. However, in a particularly comfortable yet reliable embodiment, the fluid connection is automatically established by moving the carriage toward the final discharge position.

[0158] As already mentioned before, in one embodiment, the flow connection is established before the carriage reaches the final discharge position. In an alternative embodiment, the carriage must be in its final discharge position to establish the flow connection either automatically or by an additional operating step to be performed by the user.

[0159] In an embodiment, the activation device is positioned inside the housing so as to project into the receiving space when the carriage moves from the starting position toward the final discharge position. By projecting into the receiving space, the activation device can interact with a container loaded into the receiving space, for example by breaking a seal of the container.

[0160] The activation means may be provided with means for rupturing the seal. In particular, these means are adapted to provide a piercing, penetration, puncturing and / or perforating action against the seal.

[0161] This embodiment has the advantage that the containers loaded into the receiving space can be automatically activated in a simple and reliable manner simply by pushing the carrier comprising the containers into the housing of the ejector.

[0162] Means such as wing-like protrusions may be formed on the outside of the housing so that the ejector can be used like a conventional syringe, i.e., by placing a finger on each protrusion and a thumb on the proximal end of the holder or a container loaded into the holder to hold the ejector, thereby providing comfortable one-handed operation of the ejector.

[0163] The discharge device, including an inlet opening, an outlet opening, and a fluid passage extending between these openings, can be at least partially integrally formed with the housing of the discharger. In an embodiment, the discharge device can include a portion integrally formed with the housing and one or more separate portions connected to the integral portion. In such an embodiment, the activation device can be formed by a portion integral with the housing, by a separate component of the discharge device, or by both.

[0164] The discharge device may have a proximal portion substantially facing the receiving space, the activation means, and an inlet opening formed at or integrated into the proximal region.The proximal region may be at least partially formed integrally with the housing.

[0165] To facilitate loading a container into the carrier, the carrier may have a proximal end with an insertion opening, through which the receiving space is accessible, wherein the carrier is adapted to be loaded with the container by sliding the container through the insertion opening into the receiving space. The receiving space may be adapted or matched to the container such that, when the container is loaded into the carrier, the proximal end face of the container is flush with the proximal end of the carrier. In this way, the carrier and the loaded container form a common proximal end face, which the user acts on like a button.

[0166] In another embodiment, the discharge device is adapted to guide the carriage along the longitudinal axis when the carriage moves from the starting position toward the final discharge position. In this embodiment, guiding the carriage is an additional function given to the discharge device. By guiding the carriage, the stability and reliability of the discharge machine are improved.

[0167] The drain device may have a proximal portion including an inlet opening, and the carrier may have a distal opening, wherein the drain device may extend with its proximal portion through the distal opening into the carrier. In this embodiment, by extending into the carrier, the drain device may be used to guide axial movement of the carrier and, at the same time, may interact with a container loaded into the carrier to establish a flow connection for the fluid in the container.

[0168] In particular, the proximal portion of the discharge device is sealingly mounted in the bracket to prevent leakage of fluid through the distal opening of the bracket. Mounting the proximal portion of the discharge device in the bracket eliminates the need for a separate sealing element, thereby providing a simple and effective concept for ensuring that fluid from the container flows at least substantially only into the inlet opening and through the discharge passage of the discharge device.

[0169] In an embodiment, the outer diameter of the proximal portion of the discharge device is smaller than the inner diameter of the carrier in the region of the sealed space. This creates a receiving space for a wall portion of the container, which is arranged around the proximal portion of the discharge device when the carrier is moved toward the final discharge position. Furthermore, this concept allows for efficient use of the available space within the housing, minimizing the outer dimensions of the housing and, therefore, the discharger as a whole.

[0170] In an embodiment, the carrier generally has a multi-cylindrical shape, comprising at least a proximal cylindrical portion and a distal cylindrical portion. While the proximal cylindrical portion may define a receiving space for the container, the distal cylindrical portion may be used to guide the carrier within the housing or at least to assist in guiding the carrier while receiving the proximal portion of the discharge device.

[0171] The outer diameter of the proximal cylindrical portion of the bracket may be greater than the outer diameter of the distal cylindrical portion of the bracket.

[0172] In further embodiments, the inner diameter of the proximal cylindrical portion of the bracket is greater than the inner diameter of the distal cylindrical portion of the bracket.

[0173] The different inner diameters of the cylindrical portion of the bracket can be used to provide additional functionality to the bracket. In particular, a transition portion can be provided within the bracket between the proximal and distal cylindrical portions. This transition portion can define the distal end of the receiving space and serve as a stop for a container loaded into the receiving space.

[0174] In an embodiment, the drainer further comprises fixing means adapted to prevent the carriage from being unintentionally moved from the starting position along the longitudinal axis. These fixing means facilitate handling of the drainer by avoiding unintentional manipulation of the carriage.

[0175] In particular, the securing device may include a pin / slot arrangement having at least one pin formed on the bracket and at least one slot formed in the wall of the housing, the pin being guided by the slot. The slot may include a first portion extending in a circumferential direction and merging into an axial slot portion extending along the longitudinal axis of the discharger. Such securing devices require the user to rotate the bracket relative to the housing before the bracket can be pushed into the housing and into the final discharge position.

[0176] Typically, the volume for the fluid in the container can be dimensioned as needed according to the respective intended use.For different volumes and therefore for different fluid amounts included in the container, the outer shape and outer dimensions of the container can be the same.

[0177] Against this background, the present disclosure also relates to a set of a plurality of containers having at least substantially the same outer shape and outer dimensions, but differing from one another with respect to the volume or amount of fluid contained.

[0178] The outer shape of the container may be generally cylindrical.

[0179] In an embodiment, the fluid inside the container is protected from the environment by a rupturable seal.

[0180] The container may have a distal face, at least a portion of which is formed by a rupturable seal.

[0181] The seal may be formed by a portion of the outer wall of the container, the thickness of the sealed portion being less than the thickness of the remaining portion of the wall. In an alternative embodiment, the outer wall of the container defines an opening that is closed by a separate sealing element after the fluid is filled into the container. The sealing element may be in the form of a foil or a film.

[0182] The drainer of the present disclosure can be provided with a set of different brackets, each differing in the size and / or shape of its receiving space. This allows the drainer to be loaded with a variety of containers, thereby increasing the drainer's range of uses. Alternatively, a set of inserts can be provided, each compatible with a specific container type, allowing the drainer to be adapted to a specific container type by inserting the insert into the bracket. In other words, a single bracket can be adapted to different containers using a specific adapter that is inserted into the bracket.

[0183] In another embodiment, the discharge device of the discharger has a proximal portion including an inlet opening, and when the carriage is moved toward the final discharge position, the proximal portion sealingly fits into the container to at least substantially prevent fluid from leaking out of the container past the discharge device. Fitting the proximal portion into the container also assists in guiding the carriage, and thus the container, as the carriage is pushed into the housing.

[0184] The container may have a cylindrical wall portion having a thickness that is at least approximately the same as the difference between the inner diameters of the proximal and distal cylindrical portions of the carrier. In this embodiment, when the container is loaded into the carrier, the distal cylindrical portion of the carrier and the container together may define a cylindrical space having a constant inner diameter, which may be at least substantially the same as the outer diameter of the proximal portion of the discharge device. Thus, when the carrier including the loaded container is pushed into the housing, the proximal portion of the discharge device enters the container starting from the distal cylindrical portion of the carrier, thereby permanently guiding the carrier into its final discharge position.

[0185] In an embodiment, the discharge device has a proximal portion including an inlet opening, and the container has an inner wall that bounds a fluid space of the container, wherein the inner wall includes a proximal section, and wherein the proximal portion of the discharge device and the proximal section of the inner wall are shaped to be at least approximately complementary to each other. In this embodiment, the fluid space of the container is more or less completely filled by the discharge device, so that when the carrier is in its final discharge position, the amount of residual fluid contained in the fluid space is minimized.

[0186] In another aspect, the present disclosure also relates to the use of a drain as disclosed herein or a drain system as disclosed herein for draining a liquid comprising at least one pharmaceutical, dental or veterinary agent, wherein, in particular, the amount of liquid is in the range of 0.2 ml to 2 ml and preferably approximately 0.5 ml.

[0187] According to the present invention, a syringe is provided, comprising a hollow body, a piston, and an intermediate piece. The hollow body has an enclosed hollow body surface and a passageway formed therein. An axis is formed along the axial longitudinal direction of the hollow body. The passageway has a rear body opening and a front body opening arranged opposite each other in the longitudinal direction. A first needle seat is formed at the front body opening, and a needle cannula is disposed in the needle seat and is movable relative to the needle seat along the axis. A piston is disposed in the hollow body and is movable along the axis in the passageway, wherein the piston includes a front piston opening, a rear piston end, and an enclosed intermediate wall. The intermediate wall is disposed between the front piston opening and the rear piston end and forms a receiving chamber for receiving at least one fluid. The intermediate piece is disposed in the receiving chamber and is movable along the axis, wherein a first sealing area that seals the receiving chamber in the storage position acts between the intermediate wall and the intermediate piece. A second needle seat and a supply space are formed in the intermediate piece, wherein the supply space is particularly formed as a passageway or in the manner of a passageway, wherein the second needle seat and the supply space are in fluid communication with each other. The piston, the hollow body and the intermediate piece can be moved into a release position by means of a coaxial relative movement starting from a storage position. In the storage position, a seal is provided between the supply space and the receiving chamber, which can be released by the coaxial relative movement so that the receiving chamber and the supply space are in flow communication in the release position.

[0188] The syringe can be, for example, a single-use disposable syringe. Plastic (particularly PP or COC) can be used to manufacture the syringe. Possible materials include PE, PA, PBT, and PMMA. However, the material can also be glass, a metal alloy, or a metal. Advantageously, the material can be a pressure-resistant material.

[0189] The hollow body can be a tubular hollow body, preferably, but not necessarily, having a circular, elliptical, or polygonal base surface. The hollow body has a surrounding hollow body surface, which forms a passageway therein. The axis is formed along the axial longitudinal direction of the hollow body, preferably passing through the center of mass of the two base surfaces of the hollow body. The hollow body can be configured as a primarily hollow cylindrical tube, wherein the passageway has a rear body opening and a front body opening arranged opposite each other in the longitudinal direction.

[0190] The first needle seat is formed at the front body opening, wherein the needle cannula is arranged in the first needle seat, and the needle cannula is movable along the axis. For example, the front body opening can have a nozzle shape. The first needle seat can be configured in a tubular form in the hollow body and have a needle seat opening. The first needle seat can preferably but not necessarily have a circular, elliptical or polygonal base surface. The first needle seat can be aligned along the axis. The fluid can flow out of the receiving chamber in the needle cannula, in particular the first fluid and the second fluid can flow out of the receiving chamber one after another. In the storage position, the needle cannula can be arranged in the first needle seat so that the needle cannula is completely moved into the hollow body. In the release position, the needle cannula can be moved out of the first needle seat (i.e., moved out of the hollow body), wherein the needle cannula can be retained in the middle piece. In the retracted (drawn in) position, the needle cannula can be completely moved into the hollow body and can no longer be arranged in the first needle seat.

[0191] The piston is arranged in the hollow body, particularly in the passage, and is movable along the axis. The piston includes a front piston opening arranged in the direction of the front body opening and a rear (particularly closed) piston end. The front piston opening and the rear piston end are arranged relative to each other in the longitudinal direction. The piston can be moved from a storage position to a release position, and vice versa. Additionally, the piston can be moved in particular into a flush position and a retracted position, wherein the flush position is located between the release position and the retracted position. For example, as with conventional syringes, the piston can be moved from the storage position to the release position by pressing on the rear piston end (which can be configured as a button, for example). To prevent the piston from being pressed further into the hollow body in the release position, the rear piston end can be configured as a support device, for example, as a protrusion. In the storage position, the piston can be held in the hollow body by means of a retaining device, that is, the piston can be prevented from moving, and in practice, the piston can only move if a specific force is applied from the rear piston opening. The retaining device can, for example, include a recess in the piston and a groove in the hollow body, or vice versa. For example, the dimple may be latched in the groove.The piston may also be guided in the axial direction by means of a guide element in the passage.

[0192] The piston also includes an enclosing intermediate wall, which is arranged between the front piston opening and the rear piston end and forms a receiving chamber for receiving fluids (particularly the first fluid and the second fluid). The receiving chamber can be configured as a U-shaped tube, wherein the base surface of the receiving chamber can have a circular, oval or polygonal base surface. The receiving chamber can particularly have a volume of 0.1 ml to 100 ml, preferably a volume of 0.5 ml to 2 ml.

[0193] The second needle hub is formed in an intermediate piece, which is arranged in the receiving chamber and is movable along the axis, wherein the needle cannula is arranged in the second needle hub and is movable along the axis. However, the needle cannula can also be retained in the intermediate piece, in particular in the inner element or in the second needle hub, so that the needle cannula cannot be coaxially moved independently of the intermediate piece. The second needle hub can be aligned along the axis. In the storage position, the needle cannula can be arranged in the first needle hub and the second needle hub, so that the needle cannula can be at least approximately completely moved into the hollow body. In the release position, the needle cannula can be removed from the hollow body, wherein the needle cannula is securely held in the axial direction, for example by means of a needle holder in the intermediate piece, in particular by means of a needle holder in the second needle hub. The needle cannula can, for example, be latched to the needle holder or can be coupled or clamped into the needle holder. By means of force transmission from the piston to the intermediate piece, the intermediate piece can be moved in the passage along the axis.

[0194] According to the present invention, a supply space is formed in the middle piece, and the supply space is in flow communication with the second needle seat. The supply space can be provided in the form of one or more holes in the middle piece. The hole can, for example, have a maximum diameter of 3 mm and can, for example, be cylindrical. The cross-sectional shape of the hole perpendicular to the axis or parallel to the axis can, for example, be rectangular or roughly polygonal. The supply space can be arranged at an angle of, for example, 50 to 90 degrees to the longitudinal axis, preferably at an angle of at least approximately 90 degrees to the axis. Flow communication will be understood in particular as allowing fluid to flow or stream from the supply space into the second needle seat and into the needle cannula.

[0195] The piston, hollow body, and intermediate piece are movable relative to one another into a release position by coaxial movement starting from a storage position. In the storage position, the receiving chamber is sealed relative to the supply space. The storage position is specifically understood to mean that the piston can be pulled out of the hollow body, so that the front piston opening is located adjacent to the rear body opening, and the seal prevents fluid from flowing from the receiving chamber into the intermediate piece and from there into the needle cannula. The release position is understood to mean that the piston has been moved into the hollow body by coaxial movement, for example by pressing on the rear piston end, and the seal is thereby released, allowing fluid to flow from the receiving chamber into the intermediate piece and from there into the needle cannula. In this regard, starting from the storage position, the needle cannula can first be removed, with the seal still activated. During the transition to the release position, the seal is deactivated. In the subsequent retracted position, when the piston is retracted again, the needle cannula can also be pulled into the hollow body.

[0196] The syringe according to the present invention has the advantage that it serves as a functional primary packaging device, and the active ingredient is already present in the syringe without having to be retracted first, thereby eliminating, for example, contamination risks. Furthermore, since the complicated insertion or tightening of the needle cannula is eliminated, the syringe is easier to operate, for example, with one hand. The optionally provided retracted position has the advantage that the risk of injury or infection caused by the needle cannula can be eliminated after use of the syringe.

[0197] In a possible embodiment of the present invention, the intermediate element comprises an outer element and an inner element. In this regard, the inner element comprises a second needle hub and a seat for the outer element. The inner element and the seat are specifically arranged so that axial movement of the inner element relative to the outer element in the direction of the rear body end is limited by the seat. The supply space may have a conical design. A seal may be formed between the inner and outer elements.

[0198] The middle piece can be in one part or in multiple parts. The middle piece can include an outer element and an inner element, wherein the second needle seat can be arranged either at the outer element or at the inner element. The inner element can be partially or completely arranged in the outer element. The inner element can particularly be arranged in a hole that can have a circular or polygonal cross-section. The supply space can be arranged at the inner element or at the outer element. The inner element further includes a support for the outer element. The support can, for example, be constructed as a peripheral edge (in the form of one or more webs) or a step. In the storage position, a first sealing area can be formed between the middle wall and the outer element of the middle piece, and a second sealing area can be formed between the inner element and the outer element. The first sealing area can be formed as a seal, for example, as a groove at the middle wall of the receiving chamber and a pit at the middle piece (particularly at the outer element), or vice versa. The second sealing area can also be formed as a seal, for example, as a groove at the outer element and a pit at the inner element. The first sealing area and / or the second sealing area can alternatively be formed as an O-ring seal. The first sealing area and / or the second sealing area may comprise one or more seals.Thus, the active ingredient may advantageously already be stored in the syringe and a simplified release principle of the active ingredient may be achieved.

[0199] In a possible embodiment of the present invention, the receiving chamber is divided into a first chamber and a second chamber by means of a separating element. In the flush position, the second chamber and the supply space can be in flow communication. In the storage position, a sealing area is formed and arranged between the intermediate wall and the separating element so that the second chamber and the supply space are not in flow communication. The separating element can be constructed as a membrane or a plug, which is movably arranged in the receiving chamber along an axis. With regard to a multi-part embodiment of the middle piece (for example, an inner element of the middle piece), the middle piece can be formed as a mandrel in the direction of the rear body end to break the separating element.

[0200] The receiving chamber can be divided into exactly two chambers, namely a first chamber and a second chamber, by means of a separation element. However, the receiving chamber can also be divided into more than two chambers, each of which is separated by means of multiple separation elements and can receive more than two fluids in total. Each separation element can be configured as a membrane or a plug.

[0201] Generally speaking, the or each separation element can be formed from a plastic or metal material. The separation elements are arranged in the receiving chamber so that the respective chambers are separated in a fluid-tight manner. If a first chamber and a second chamber are provided, they can receive two fluids, wherein the first fluid can be arranged in the first chamber and the second fluid can be arranged in the second chamber. In addition, in the storage position or in the release position, a sealing area can be formed and arranged between the intermediate wall and the separation element so that there is no flow connection between the second chamber and the supply space, and between the second chamber and the first chamber. This sealing area can be configured as a seal, for example, as a groove in the intermediate wall and a complementary recess in the separation element, or vice versa. However, the sealing area can also be an O-ring. The sealing area can include one or more seals. A flush position is understood to mean that the second chamber and the supply space are in flow connection with each other. The separation element or its position can be mechanically changed to establish this flow connection. For example, the membrane can be pierced by a mandrel or the sealing area between the separation element and the intermediate wall can be deactivated so that the second chamber and the supply space are in flow connection. In contrast, in the storage position and / or in the release position, the separating element separates the second chamber from the first chamber and the second chamber from the supply space, so that they are not in fluid communication. In this regard, the first fluid can be, for example, a medicament to be dispensed, and the second fluid can be a flushing solution. Advantageously, the first and second fluids, but also more than two fluids, can be functionally separated. In addition, since the active ingredient is already contained in the syringe and no longer needs to be drawn into the syringe, the handling and operation of the syringe are much simpler.

[0202] In a possible embodiment of the present invention, the inner element of the middle piece is constructed as another hollow body, wherein the piston is movably arranged in the other hollow body. The other hollow body can be a tubular hollow body, preferably but not necessarily having a circular, oval or polygonal base surface. The shape of the other hollow body can correspond to the shape of the hollow body, wherein the other hollow body can be arranged in the passage of the hollow body. The other hollow body can include another passage and extend along the axis. The other hollow body can be constructed as a hollow cylindrical tube. In addition, the piston can be arranged in the other hollow body. The coaxial movement of the piston can be carried out along the axis in the other hollow body, and the other hollow body then moves along the axis in the hollow body. Therefore, better support and guiding stability of the middle piece is advantageously established.

[0203] In a possible embodiment of the invention, a spring is arranged in the passage, and when the restoring force of the spring is overcome, the piston can be moved in the direction of the front body opening of the hollow body. Advantageously, the needle cannula can be pulled more easily into the hollow body with the aid of the spring, i.e., the spring can ensure that the syringe moves into the retracted position or can assist in the transition to the retracted position.

[0204] In a further possible embodiment of the invention, means are provided for automatically pivoting or deflecting the intermediate piece laterally in the end position and / or in the retracted position. These means act in particular between the rear end of the receiving chamber and the rear end of the intermediate piece and in particular comprise an inclined surface. By means of such means, a pivoting or deflecting force can act on the needle cannula via the intermediate piece and the second needle seat, which pivoting or deflecting force attempts to move the needle cannula from a working alignment parallel to the longitudinal axis of the hollow body into a safety alignment inclined relative to the longitudinal axis. As soon as the needle cannula is disengaged from the first needle seat, which is formed at the front body opening and also ensures that the needle cannula is in working alignment against the action of the pivoting or deflecting forces.

[0205] The present invention further relates to a syringe as described herein, wherein the receiving chamber already contains at least one fluid, in particular a liquid containing at least one medicament to be dispensed, wherein, in particular, the receiving chamber contains the liquid containing at least one medicament to be dispensed in a first chamber of the receiving chamber and a flushing solution in a second chamber of the receiving chamber.

[0206] Furthermore, the present invention relates to the use of a syringe as described herein for discharging a fluid already contained in a receiving chamber without aspirating the fluid, in particular for injecting a liquid containing at least one medicament to be dispensed (administered), wherein, in a first phase, the liquid containing at least one medicament to be dispensed is discharged from a first chamber of the receiving chamber and subsequently, in a second phase, a flushing solution is discharged from a second chamber of the receiving chamber.

[0207] According to the present invention, a dispenser, preferably a non-reusable syringe, for discharging a predetermined amount of fluid (preferably from a separate container), in particular a liquid comprising at least one pharmaceutical, dental, or veterinary agent, comprises a discharge section defining a longitudinal axis and having a proximal end and a distal end, and a discharge passage for the fluid extending between an inlet opening and an outlet opening of the discharge section. The dispenser further comprises an intermediate section comprising a distal portion cooperating with the proximal end of the discharge section and a proximal portion defining a receiving space suitable for receiving a separate container containing a quantity of fluid to be discharged (preferably to be discharged by the dispenser). The distal portion and the proximal portion are formed in one piece and interconnected by a rupturable section.

[0208] The present disclosure is not limited to the medical, dental, or veterinary industries and may be used in other appliances where it is desired to discharge a predetermined amount of fluid in a reliable and uniform manner. The present disclosure is also not limited to the discharge of fluids (such as liquids). The discharger as disclosed herein may alternatively be suitable for or used to discharge viscous or gel-like or even powdered or fine-grained materials.

[0209] The rupturable section of the intermediate section may preferably comprise a predetermined rupture area or rupture point adapted to rupture upon application of an axial force to the intermediate section, in particular along the longitudinal axis, in particular towards the distal end of the discharge section.

[0210] Advantageously, the force at which the predetermined rupture area or point is intended to rupture may be approximately within the range of forces that an adult can apply by pressing the thumb and index and / or middle finger together.

[0211] It is also contemplated that the predetermined rupture area or point may be adapted to rupture upon application of a rotational motion to the proximal portion of the intermediate section relative to the distal portion of the intermediate section, or vice versa.

[0212] The rupturable section can preferably have the shape of a lip, a web, an edge, a shoulder, a membrane, etc. Advantageously, the rupturable section can comprise a tearable membrane, in particular made of the same material as the distal portion and / or the proximal portion of the intermediate section. When a force is applied, the tearable membrane can stretch to a limited extent until it eventually ruptures.

[0213] The intermediate section may be formed by injection moulding and may preferably consist of an elastically deformable polymer selected from the group comprising polypropylene, cycloolefin polymers, polyethylene, polyamide, polybutylene terephthalate and polymethyl methacrylate.

[0214] It may be preferred that the rupture zone may comprise or be made of a different material than the distal and / or proximal portions of the middle section. By selecting a suitable material for the rupture zone, the predetermined rupture area or point may be adjusted and adapted to the type of use of the ejector.

[0215] In a preferred embodiment, after the rupture section ruptures, the proximal portion of the intermediate section can be movable relative to the distal portion of the intermediate section along the longitudinal axis between a starting position and a final discharge position. The movement direction of the proximal portion can preferably be along the longitudinal axis toward the distal end of the discharge section.

[0216] The position of the proximal portion of the intermediate section before the rupture of the rupturable section can be referred to as the "initial position". The "starting position" can be defined as the position reached by the proximal portion of the intermediate section immediately after the rupture of the rupturable section, i.e., when the proximal portion of the intermediate section is movable relative to the distal portion. The "final discharge position" can be defined as a position of the proximal portion of the intermediate section such that—once reached by the initial movement of the proximal portion of the intermediate section—the proximal portion cannot move further in its initial direction.

[0217] In this context, the rupturable section can advantageously also function to facilitate child safety, as it can prevent the proximal portion of the intermediate section from inadvertently moving along the longitudinal axis in a manner that would allow discharge of fluid. The provided discharger can therefore be considered child-resistant, at least with respect to young children.

[0218] However, the ejector may further comprise fixing means, which may be adapted to prevent the proximal portion of the intermediate section from being unintentionally moved along the longitudinal axis from the starting position.

[0219] Preferably, in the starting position, the proximal part of the intermediate section can at least partially protrude from the distal part of the intermediate section and can preferably receive the distal part to be guided through the proximal part when the proximal part moves towards the distal end of the discharge section and towards the final discharge position.

[0220] According to this embodiment, the outer diameter of the distal portion of the intermediate section can preferably be substantially equal to or slightly larger than the inner diameter of the proximal portion of the intermediate section so that the distal portion can be guided through the proximal portion after the rupture section ruptures. For example, the outer diameter of the distal portion can be between 3mm and 15mm, preferably between 6mm and 7mm. The inner diameter of the proximal portion can be as little as 0.1mm or 0.2mm than the outer diameter of the distal portion. The inner diameter of the separate container can be equal to the inner diameter of the proximal portion or the inner diameter of a part of the proximal portion. The inner diameter of the receiving space of the proximal portion can be equal to the outer diameter of the separate container, which can be, for example, in the range of 5mm to 20mm and preferably between 8mm and 9mm.

[0221] Advantageously, in the initial position of the proximal portion of the intermediate section, ie before the rupture of the rupturable section, the distal portion of the intermediate section may be at least partially enclosed by the proximal portion. However, the distal portion may also be completely enclosed by the proximal portion.

[0222] After the rupture of the rupture section, the distal portion and / or the proximal portion preferably retains its structure. In other words, the rupture of the rupture section advantageously "breaks" only the rupture section itself, but does not change the form or structure of the distal portion and the proximal portion. The rupture section can have a shape (preferably circular or rounded) around the longitudinal axis.

[0223] If the structure of the distal portion and / or the proximal portion is maintained, the distal portion may continue to cooperate with the proximal end of the discharge section after the ruptureable section has ruptured.

[0224] In an embodiment of the discharger, the distal portion of the intermediate section and the proximal end of the discharge section can cooperate by means of a plug connection. The proximal end of the discharge section can preferably be simply inserted into an opening at the receiving end of the distal section and can be held in place, in particular, in a force-locking manner. However, additional interconnection (such as gluing or welding, in particular laser welding) is not necessarily required but can be performed.

[0225] The cooperation between the proximal end of the discharge segment and the distal portion of the intermediate segment can also be based on a snap-on connection. In this context, for example, a locking element (such as a locking pin, etc.) can be provided at the distal portion, and a corresponding locking element can be provided at the proximal end. The proximal end of the discharge segment can then slide over the locking element at the distal portion when inserted through the opening into the distal portion of the intermediate segment. This locking element, in conjunction with the corresponding locking element provided at the proximal end, can prevent the discharge segment from slipping or falling out. Additional interconnection methods, such as welding or gluing, can be omitted.

[0226] Another possible type of cooperation between the distal part of the intermediate section and the proximal end of the discharge section may be a screw connection, wherein the distal part of the intermediate section may preferably be provided with an internal thread and the proximal end of the discharge section may preferably be provided with an external thread.

[0227] Preferably, the distal portion of the intermediate section may further include a stopper portion that serves as a stopper for the proximal end of the discharge section when the proximal end of the discharge section is inserted into the distal portion. In other words, the stopper portion may limit the extent to which the distal end of the discharge section can be inserted into the proximal portion of the intermediate section.

[0228] It is particularly preferred that only between one-tenth and one-twentieth of the total length of the discharge segment be accommodated in the distal portion of the intermediate section. In this way, the size of the distal portion of the intermediate section can be reduced to the minimum necessary to secure the proximal end of the discharge segment in place. Thus, material consumption can be kept to a minimum.

[0229] In a further embodiment of the discharger, the distal part of the intermediate section may comprise activation means for establishing a flow connection for the fluid from within the receiving space of the proximal part of the intermediate section to the inlet opening of the discharge section.

[0230] One concept of the present disclosure is to avoid storing fluid directly within the discharger itself. By providing an intermediate section comprising a proximal portion with a receiving space, a separate container containing a predetermined amount of fluid to be discharged can be loaded into the discharger. This allows for a virtually unlimited storage life of the discharger itself. Furthermore, this concept allows for easy and reliable operation of the discharger, as activation means can automatically establish a fluid connection from the container loaded into the receiving space of the proximal portion of the intermediate section to the inlet opening of the discharge device.

[0231] Advantageously, after rupturing the rupturable section, the flow connection may be automatically established by moving the proximal portion of the intermediate section relative to the distal portion of the intermediate section along the longitudinal axis from a starting position towards the distal end of the discharge section and towards the final discharge position.

[0232] In the initial position, ie before the rupture of the rupturable section, and / or in the starting position of the proximal part of the intermediate section, the activation means may preferably be inoperable, which means that no connection to the fluid to be discharged may be established.

[0233] Advantageously, when the proximal portion of the intermediate section is halfway between the starting position and the final discharge position, the activation means may establish a flow connection such that fluid may start flowing through the discharge passage of the discharge section before the proximal portion may reach the final discharge position.

[0234] In another embodiment, the activation means may establish the flow connection when the proximal portion of the intermediate section is brought from its initial position to its starting position, ie the fluid connection may be established during rupture of the rupturable section.

[0235] It is also conceivable that the activation means may require the user to perform additional operating steps in order to actually establish the flow connection. However, it is particularly preferred that the flow connection can be automatically established by moving the proximal part of the intermediate section towards the final discharge position.

[0236] In yet another embodiment, the activation device can be at least partially positioned within the proximal portion of the intermediate section so as to protrude into and beyond the receiving space when the proximal portion moves from the starting position toward the final discharge position. By protruding into and beyond the receiving space defined by the proximal portion (i.e., beyond the receiving end of the proximal portion), the activation device can be capable of interacting with a container loaded into the receiving space, for example, by rupturing a seal of the container.

[0237] In this context, it is preferred that the activation means can be provided with means for rupturing the seal, in particular for piercing, penetrating, puncturing and / or perforating the seal.

[0238] The activation device may preferably include a puncture tip having a flow channel for establishing a fluid flow connection from the receiving space to the inlet opening of the discharge section. Advantageously, the outer surface of the puncture tip may have a convexly curved configuration, particularly a dome-shaped configuration, and may preferably be rotationally symmetrical. The flow channel may preferably be centrally located within the puncture tip, particularly along the rotational axis of the puncture tip. However, the flow channel may also be located at an offset position relative to the rotational axis of the puncture tip. It is particularly preferred that the puncture tip be rotationally symmetrical about the longitudinal axis defined by the discharge section.

[0239] According to another embodiment, the puncture tip may include a ridge at its apex, wherein the ridge may preferably be perpendicular to the longitudinal axis. However, the ridge may also be inclined or skewed relative to the longitudinal axis. Advantageously, the ridge may be interrupted by the flow channel, forming two protrusions adjacent to the flow channel. In other words, the flow channel may divide the ridge into two separate ridge-like protrusions, which may preferably have approximately the same size.

[0240] In an embodiment, the activation means may be sealingly mounted within the proximal portion of the intermediate section so as to at least substantially prevent leakage of fluid through the receiving end of the distal portion of the intermediate section. In this context, it is particularly preferred that the activation means or the distal portion of the intermediate section may include a sealing lip or the like that provides a seal against the inner wall of the proximal portion of the intermediate section.

[0241] Advantageously, the distal portion is adapted to advance into the interior of the proximal portion (i.e., into the proximal portion) after the rupturable section ruptures, wherein a sealed connection is created between the distal portion and the proximal portion. When advanced into the interior of the proximal portion (after the rupturable section ruptures), the distal portion can act as a piston that displaces fluid stored in a separate container. Due to this sealed connection, undesirable leakage of the container and / or the proximal portion is prevented.

[0242] Advantageously, a sealing lip, a sealing connection, or the like can be provided at the activation means, in particular at the puncture tip, preferably at the outer surface region before the puncture tip begins to taper. The sealing lip can be formed integrally with the activation means, which advantageously eliminates the need for a separate sealing element (such as a gasket or O-ring). Thus, an efficient concept is provided that ensures that fluid from the container flows at least substantially exclusively into the inlet opening and through the discharge passage of the discharge device.

[0243] In a preferred embodiment, the distal portion of the intermediate section may consist of a first substantially cylindrical portion protruding from the proximal portion of the intermediate section and a second portion serving as the activation means. According to this embodiment, the activation means may preferably be completely enclosed by the proximal portion of the intermediate section. Furthermore, the first cylindrical portion protruding from the proximal portion may include a sealing lip. According to this embodiment, the rupturable portion may preferably have the shape of a web and may be located at the distal end of the receiving space facing away from the proximal portion, where the first cylindrical portion of the distal portion begins to protrude.

[0244] In a further embodiment, the activation means may be shaped to be at least approximately complementary to an inner wall portion of a container suitable for loading into the receiving space, so as to minimize the amount of residual fluid contained in the container when the proximal portion of the intermediate section is in its final discharge position. In other words, the shape of the inner contour of the container may be substantially complementary to the activation means, which are preferably in the shape of a puncture tip.

[0245] In this context, the expression "substantially" implies that the shape of the inner wall portion of the container may deviate from the exact complementary shape of the activation means, especially in areas where the activation means may comprise ridges or ridge-like protrusions, if applicable.

[0246] This design allows for an almost complete drainage of the fluid, as the available space for the fluid can be completely filled by the activation device, resulting in an almost complete drainage of the fluid.

[0247] The proximal portion of the intermediate section may preferably have a receiving end with an insertion opening, wherein the receiving space is accessible through the insertion opening. Furthermore, the proximal portion may preferably be adapted to be loaded with a container by sliding the container through the insertion opening into the receiving space. The receiving space may preferably be sized such that the container at least partially protrudes from the proximal portion.

[0248] By keeping the portion of the container inserted into the receiving space as small as possible, the use of material can be kept to a minimum, since according to the invention, the container does not require further boxing. In this context, preferably only one third, more preferably only one quarter, in particular only one tenth of the total length of the container can be received in the receiving space defined by the proximal portion of the middle section.

[0249] Advantageously, inside the proximal portion of the intermediate section, a transition portion can be provided, which serves as a stop for the container loaded into the receiving space. This transition portion can be in the shape of a shoulder or a seat and can determine the length of the container received in the receiving space.

[0250] The container can preferably cooperate with the receiving space of the proximal part of the intermediate section by means of a plug connection or a snap-in connection, as has been previously described with respect to the discharge section cooperating with the distal part of the intermediate section.

[0251] In an embodiment, the discharger may further comprise a container, in particular in the form of a cartridge or a capsule, wherein the container may comprise a predetermined amount of fluid to be discharged by the discharger.

[0252] The outer shape of the container may be generally cylindrical, and the fluid to be discharged may preferably be contained in a fluid reservoir within the container.

[0253] Advantageously, the fluid inside the container may be protected from the environment by the rupturable seal, in particular the shielding foil.The container may have a distal face, at least a portion of which is formed by the rupturable seal.

[0254] The seal may be formed by a portion of the outer wall of the container, wherein, preferably, the thickness of the sealed portion may be less than the thickness of the remaining portion of the wall. Alternatively, the outer wall of the container may define an opening that can be closed by a separate sealing element after the fluid is filled into the container. The sealing element may be in the form of a foil or a film.

[0255] In an embodiment, the discharge section may comprise protrusions such as finger flanges, finger rests or finger grips, in particular these protrusions are moulded on or formed integrally with the discharge section.

[0256] Thus, the discharger can be used like a conventional syringe, i.e., by placing one finger on each protrusion and a thumb on the proximal end of the container loaded into the receiving space of the proximal portion of the intermediate section to hold the discharger, thereby providing comfortable one-handed operation of the discharger. In this way, the container can be activated like a button, with the user pressing the container with his or her thumb while counteracting this pressing actuation by holding the discharge section with two fingers behind the protrusions.

[0257] In this way, an axial force toward the distal end of the discharge section can be applied to the proximal portion of the intermediate section. Consequently, the rupturable section can be ruptured, and the proximal portion can be shifted to its starting position. By further applying the axial force, the proximal portion, together with the container loaded into the receiving space of the proximal portion, can be moved further toward the distal end of the discharge section. Thus, the activation device of the distal portion of the intermediate section can establish a flow connection for the fluid from the receiving space to the inlet opening of the discharge section, preferably by rupturing a seal located at the distal end face of the container. When the activation device enters the fluid reservoir of the container, the fluid can be pushed out of the discharge container through the discharge passage of the discharge section.

[0258] By providing the protrusion directly on the discharge section, the need for an additional housing portion can be omitted. Consequently, material consumption during production is correspondingly low. Furthermore, since the discharge section can be pressed against the distal portion of the intermediate section, and the container can be pressed against the proximal portion of the intermediate section, during operation of the discharger, the individual components named above—discharge section, intermediate section, and container—do not necessarily require a slip-tight connection. This significantly facilitates on-site assembly and handling of the discharger.

[0259] In other embodiments, the discharge section may include a distal portion defining an outlet opening. Preferably, the distal portion may be integrally formed or may be manufactured as a separate component, such as a spray head, needle, brush, sponge, or pipette, that can be connected to the distal end of the discharge section. For example, a spray head or sponge may be advantageous for large-area applications, while selective applications may require a needle or a small-diameter evacuated tube.

[0260] In another aspect, the present disclosure also relates to the use of a drain as disclosed herein for draining a liquid comprising at least one pharmaceutical, dental or veterinary agent, wherein, in particular, the amount of liquid may be in the range of 0.1 ml to 5 ml and preferably may be approximately 0.5 ml.

[0261] Generally speaking, the volume for fluid in the container can be dimensioned as needed according to the respective intended use.For different volumes and therefore for different fluid amounts included in the container, the outer shape and outer dimensions of the container can be the same.

[0262] This applicator for nasal decolonization using a fluid includes: an applicator tip suitable for insertion into the nasal cavity, the applicator tip being configured to store and release the fluid; and a support member to which the applicator tip is connected, wherein the applicator tip is formed from at least one of the following: open-cell foam, plastic, flocking (a material having fibers and often interwoven), cotton, polyester, rayon, calcium alginate, foam, knitted polyester, medical-grade plastic, thermoplastic elastomer, low-density polyethylene, acrylonitrile butadiene styrene, polypropylene, polyethylene, polycarbonate, polyurethane, polyetheretherketone, and polyvinyl alcohol.

[0263] In this regard it should be noted that the application tip must be shaped to complement the shape of the nasal cavity so that when the application tip is inserted into the nasal cavity, the nasal tissue is not damaged simply due to a poorly shaped design of the application tip, which could lead to further unwanted infections.

[0264] It should be further noted that the application tip is configured to store and release said fluid. This means that the application tip must have the ability to be wetted in order to transfer the fluid from, for example, the container to the nasal cavity and then be able to release the fluid inside the nasal cavity.

[0265] In this regard it should be noted that the application tip may have a 2 Up to 30mm 2 In the range, especially in the range of 15mm 2 Up to 26mm 2 The surface absorptivity is selected within the range.

[0266] This absorption allows the fluid to be stored at the application tip in such a way that the application tip acts as a foam.

[0267] It should further be noted that at least a portion of the application tip has an ethanol penetration time in the range of 10 seconds to 200 seconds and a maximum diameter of 50 μm or greater within a cross-section of 1.0 mm x 1.0 mm. In particular, the application tip comprises a polyurethane elastomer containing 20 or more pores of 300 μm or less, and in particular, the pores of the continuous-pore elastomer have a substantially circular or elliptical cross-sectional shape. Such penetration times permit release of fluid stored at the application tip. Furthermore, these penetration times are preferably achieved using a polyurethane elastomer having the properties mentioned above.

[0268] The measurement of alcohol permeability is defined in ASTM F739 and EN 374. Additionally, the water vapor transmission rate and water vapor permeability of materials are defined in the following standards: ASTM International (2016) ASTM E96 / E96M-16 - Standard Test Method for Water Vapor Transmission Rate of Materials. ASTM International, West Conshohocken, Pennsylvania; and DIN 53122 for water vapor permeability; European Standard EN 1015-19:1998 / A1:2004.

[0269] Similarly, ASTM D570 – Standard test method for water absorption of plastics, as well as ISO 62:2008 – Plastics – Determination of water absorption. ISO 175:2010 (en) Plastics – Standard test method for determining the effects of immersion in liquid chemicals.

[0270] In this regard, it should be noted that when the application tip is in a cylindrical or at least approximately cylindrical shape and has certain dimensions (which are selected to have a diameter of 3 mm and a length of 5 mm), the material of the application tip can absorb between 6 mg and 16 mg of fluid, in particular between 8 mg and 12 mg of fluid, depending on the viscosity of the fluid, wherein the fluid is optionally selected from the group consisting of nail polish remover, water, oil, alcohol (e.g. ethanol) and saline and / or the fluid has a viscosity selected in the range of 0.5 mPa to 200,000 mPa at 20°C.

[0271] In this regard, it should be further noted that with 135mm 2 and an application tip having a surface area selected within the range of 28 mN / m to 35 mN / m at 20°C can absorb between 9 mg and 35 mg of fluid, wherein the fluid is optionally selected from the group consisting of nail polish remover, water, oil, alcohol (e.g., ethanol) and saline and / or the fluid has a viscosity selected within the range of 0.5 mPa to 200,000 mPa at 20°C.

[0272] In this regard, it should be further noted that with 135mm 2 and an application tip having a surface area of ​​28 mN / m to 35 mN / m at 20° C. and a surface tension selected in the range of 28 mN / m to 35 mN / m at 20° C. can release between 6 mg and 13 mg of the fluid, wherein the fluid is optionally selected from the group consisting of nail polish remover, water, oil, alcohol (e.g., ethanol) and saline and / or the fluid has a viscosity selected in the range of 0.5 mPa to 200,000 mPa at 20° C.

[0273] In this regard, it should be further noted that with 57mm 2 and an application tip having a surface area selected in the range of 28 mN / m to 35 mN / m at 20°C can absorb between 2 mg and 35 mg of fluid, wherein the fluid is optionally selected from the group consisting of nail polish remover, water, oil, alcohol (e.g., ethanol) and saline and / or the fluid has a viscosity selected in the range of 0.5 mPa to 200,000 mPa at 20°C.

[0274] In this regard, it should be further noted that with 57mm 2 and an application tip having a surface area of ​​28 mN / m to 35 mN / m at 20° C. and a surface tension selected in the range of 28 mN / m to 35 mN / m can release between 0.3 mg and 22 mg of the fluid, wherein the fluid is optionally selected from the group consisting of nail polish remover, water, oil, alcohol (e.g., ethanol) and saline and / or the fluid has a viscosity selected in the range of 0.5 mPa to 200,000 mPa at 20° C.

[0275] This material can be successfully used to provide an applicator that avoids causing damage to the nasal cavity.

[0276] In this regard, it should be noted that the use of, for example, open-cell foam provides a foam composed primarily of interconnected pores that share some of their structure with other pores. This type of foam is softer and more flexible than closed-cell foam and allows gases and vapors to move freely through the pores and absorb liquids when immersed therein.

[0277] Other types of plastics that can be used for the applicator tip, such as HDPE and PP, provide a medical grade plastic as the applicator tip that is known to be safe for use with such an applicator and that also provides an applicator tip with the desired softness and flexibility to avoid damage to the nasal cavity.

[0278] In this regard it should be noted that the application tip can have an average value of Young's modulus selected to be 0.5 kPa to 500 kPa, preferably in the range of 1 kPa to 300 kPa, in particular in the range of 5 kPa to 250 kPa, in particular in the range of 8 kPa to 10 kPa and most preferably 9.3 kPa.

[0279] Methods for measuring the softness of plastics, such as, for example, open-cell polyurethane foams, are well known and defined in ISO 527-1:2019 (en) Plastics - Determination of tensile properties.

[0280] The material hardness of the application tip may be selected in the range of 25 to 95, in particular in the range of 40 to 60, measured according to the Shore hardness scale A (eg for thermoplastic elastomers).

[0281] The material hardness of the application tip may be selected in the range of 35 to 50, in particular in the range of 40 to 48, in particular in the range of 44 to 46, measured according to the Shore hardness scale D of, for example, LDPE.

[0282] The end of the application tip may at least partially have at least one of the following shapes: a conical outer shape, an at least substantially conical outer shape, a truncated conical shape, an at least substantially truncated conical shape, a circular shape, an at least substantially circular shape, a spherical shape, an at least substantially spherical shape, an oval shape, an at least substantially oval shape, a rounded edge and a combination of the foregoing, i.e. a shape that increases in size between the end and the middle part of the application tip.

[0283] By means of such a shape, an application tip can be provided which is formed complementary to the shape of the nasal cavity and thus reduces the risk of causing damage to the nasal cavity.

[0284] The applicator may be a 2K applicator, wherein the application tip is formed from a first material and the support is formed from a second material, optionally wherein the application tip is formed directly on the support in a two-step manufacturing process. In this way, the support can be formed to be harder than the application tip, wherein the application tip is optionally formed integrally on the support.

[0285] The application tip may be formed from high-density polyethylene, optionally sintered and having a porous volume selected in the range of 40% to 60%, preferably in the range of 45% to 55%, with a pore size in the range of 80 μm to 300 μm, in particular in the range of 100 μm to 250 μm. This sintered porous plastic material can reliably store and release fluids and is soft enough to avoid damage to the nasal cavity.

[0286] Applicator can further comprise the container that is filled with fluid (such as, liquid), wherein, application tip is configured to moisten with the liquid stored in the container, preferably, container is configured to store the fluid between 0.2ml and 200ml.In this way, the fluid to be applied can be stored in the container that is preferably sealed about environment, to provide and can store longer time period and avoid the applicator of fluid stored therein overflowing and pollution.In addition, container provides the volume that can be filled with high precision. Nasal application needs the fluid between 0.2ml and 10ml to carry out effective treatment usually, therefore providing the single use container with the filling volume of 0.2ml to 10ml is desirable, because this realizes that distributing the liquid of this amount is useful.Similarly, for the application of multiple use, it is desirable to provide the container with the filling volume selected in the range of 10ml to 200ml.

[0287] The hydrophilic properties may be taken into account during the production of the applicator foam. In this regard, the application tip may include a hydrophilic foam having a hydrophilicity ranging from 30 kg / m 3 Up to 150kg / m 3 The foam has a density of 100 μm and a porosity ranging from 60 ppi to 150 ppi. The foam is suitable for use in treating nasal decolonization.

[0288] The application tip may include a polyurethane elastomeric body containing 20 or more pores of 300 μm or less.Such foams can be used to reliably store and release fluids therefrom.

[0289] The applicator may further comprise a dispenser, wherein the support is a rod comprising a passage, and the passage is connected to or integrally formed with an outlet of the dispenser for dispensing liquid from a container of the dispenser to the application tip, so as to supply the fluid to the application tip. Providing the dispenser at the applicator enables a predetermined amount of fluid to be dispensed via the application tip in a well-defined manner.

[0290] The dispenser may include: a housing defining a longitudinal axis and having a proximal end and a distal end; a discharge device at least partially disposed within the housing and having an inlet opening within the housing and an application tip, the discharge device further defining a discharge path for the fluid extending between the inlet opening and the application tip; a holder as a container received in a proximal region of the housing and movable relative to the housing along the longitudinal axis between a starting position and a final discharge position, wherein the holder defines a receiving space adapted to be loaded with a separate container containing a quantity of fluid to be discharged; and activation means for establishing a flow connection for the fluid from the receiving space of the holder to the inlet opening of the discharge device, wherein the activation means are adapted to establish the flow connection when the holder is in or moving toward the final discharge position. Such a dispenser can be used to dispense fluids stored in separate containers in a simple and sterile manner. Furthermore, the container, which can be inserted into the holder, provides a volume that can be filled with high precision. The dispenser allows for the one-time dispensing of the predefined volume, making it possible to dispense a predefined amount of material at one time, particularly when the dispenser is of a single-use design.

[0291] In the starting position, the tray may protrude from the proximal end of the housing so as to be pushable by a user further into the housing and towards the final discharge position, and / or wherein the activation means is inoperative when the tray is in the starting position.

[0292] The flow connection can be established automatically by moving the carriage towards the final discharge position and / or before the carriage reaches the final discharge position. In this way, a dispenser that is simple to handle and use can be achieved.

[0293] The dispenser may be a syringe. Such a dispenser is simple to implement, cost-effective to manufacture and easy to handle.

[0294] The syringe may comprise a plunger and a barrel in which a fluid may be stored, wherein the plunger acts on the fluid during dispensing of the fluid from the barrel via the application tip.Such a design of the syringe is simple and easy to use.

[0295] The dispenser may be an applicator device comprising: a carrier body provided with an application tip at one end and a pin at an opposite end; a transverse channel penetrating the pin; an axial channel branching off from the transverse channel and leading to the applicator device; and a reservoir device having an annular edge seal sealingly engaging the pin, whereby the applicator device is activated by displacing the reservoir device on the pin toward the applicator device to open a flow connection between the reservoir device and the transverse channel, the reservoir device having a receptacle segment that is elastically deformable in at least a plurality of portions, such that when the applicator device is activated and a flow connection exists between the transverse channel and the receptacle segment, the fluid is discharged through the application tip by manually compressing the resiliently deformable area of ​​the receptacle segment. Providing the dispenser with an elastically deformable portion that can be used to extrude the fluid from the dispenser avoids fluid overflow and permits dispensing of a predefined amount of fluid.

[0296] The rod may be a solid rod and the solid rod may be connected to the handle of the applicator.Thereby, a versatile and simple to use applicator may be provided which utilizes a well known and therefore simple to manufacture closure.

[0297] The applicator may further comprise a container, optionally filled with said fluid, wherein the application tip is stored in the container and optionally in said fluid before use of the application tip. In this way, the fluid can be stored with the applicator in a safe and reliable manner.

[0298] The handle is optionally part of a closure for the container, and the application tip and rod may be insertable into or removable from the container. Thus, a versatile and easy-to-use applicator may be provided which utilizes a well-known and therefore simple-to-manufacture closure.

[0299] The handle may be releasably screwed to the container.Thereby, a versatile and simple to use applicator may be provided which utilizes a closure which is well known and therefore simple to manufacture.

[0300] The handle may be part of the support.This simplistic design is simple to manufacture and results in a cost-effective applicator.

[0301] The container may comprise a membrane, wherein the fluid is stored directly adjacent to the membrane and the application tip is stored at the other side of the membrane.

[0302] The support may include one or more seals configured to seal against an inner surface of the container.Such seals may prevent contaminants from entering the applicator and / or may prevent fluid from leaving the applicator.

[0303] The container can be a multi-part container having an inner container arranged within an outer container. The material stored in such a container can be protected from external contamination, resulting in an extended shelf life and sterile packaging of the applicator.

[0304] This applicator for nasal decolonization using a fluid includes: an applicator tip suitable for insertion into the nasal cavity, the applicator tip being configured to store and release the fluid; and a support member to which the applicator tip is connected, wherein the applicator tip is formed from at least one of the following: open-cell foam, plastic, flocking (a material having fibers and often interwoven), cotton, polyester, rayon, calcium alginate, foam, knitted polyester, medical-grade plastic, thermoplastic elastomer, low-density polyethylene, acrylonitrile butadiene styrene, polypropylene, polyethylene, polycarbonate, polyurethane, polyetheretherketone, and polyvinyl alcohol.

[0305] In this regard, it should be noted that the application tip must be shaped to complement the shape of the nasal cavity so that when the application tip is inserted into the nasal cavity, the nasal tissue is not damaged simply due to a poorly shaped design of the application tip, which could lead to further unwanted infections.

[0306] It should be further noted that the application tip is configured to store and release said fluid. This means that the application tip must have the ability to be wetted in order to transfer the fluid from, for example, a container to the nasal cavity and then be able to release the fluid into the nasal cavity.

[0307] In this regard it should be noted that the application tip may have a 2 Up to 30mm 2 In the range, especially in the range of 15mm 2 Up to 26mm 2 The surface absorptivity is selected within the range.

[0308] This absorption allows the fluid to be stored at the application tip in such a way that the application tip acts as a foam.

[0309] It should further be noted that at least a portion of the application tip has an ethanol penetration time in the range of 10 seconds to 200 seconds and a maximum diameter of 50 μm or greater within a cross-section of 1.0 mm x 1.0 mm. In particular, the application tip comprises a polyurethane elastomer containing 20 or more pores of 300 μm or less, and in particular, the pores of the continuous-pore elastomer have a substantially circular or elliptical cross-sectional shape. Such penetration times permit release of fluid stored at the application tip. Furthermore, these penetration times are preferably achieved using a polyurethane elastomer having the properties mentioned above.

[0310] The measurement of alcohol permeability is defined in ASTM F739 and EN 374. Additionally, the water vapor transmission rate and water vapor permeability of materials are defined in the following standards: ASTM International (2016) ASTM E96 / E96M-16 - Standard Test Method for Water Vapor Transmission Rate of Materials. ASTM International, West Conshohocken, Pennsylvania; and DIN 53122 for water vapor permeability; European Standard EN 1015-19:1998 / A1:2004.

[0311] Similarly, ASTM D570 – Standard test method for water absorption of plastics, as well as ISO 62:2008 – Plastics – Determination of water absorption. ISO 175:2010 (en) Plastics – Standard test method for determining the effects of immersion in liquid chemicals.

[0312] In this regard, it should be noted that when the application tip is in a cylindrical or at least approximately cylindrical shape and has certain dimensions (which are selected to have a diameter of 3 mm and a length of 5 mm), the material of the application tip can absorb between 6 mg and 16 mg of fluid, in particular between 8 mg and 12 mg of fluid, depending on the viscosity of the fluid, wherein the fluid is optionally selected from the group consisting of nail polish remover, water, oil, alcohol (e.g. ethanol) and saline and / or the fluid has a viscosity selected in the range of 0.5 mPa to 200,000 mPa at 20°C.

[0313] In this regard, it should be further noted that with 135mm 2 and an application tip having a surface area selected within the range of 28 mN / m to 35 mN / m at 20°C can absorb between 9 mg and 35 mg of fluid, wherein the fluid is optionally selected from the group consisting of nail polish remover, water, oil, alcohol (e.g., ethanol) and saline and / or the fluid has a viscosity selected within the range of 0.5 mPa to 200,000 mPa at 20°C.

[0314] In this regard, it should be further noted that with 135mm 2 and an application tip having a surface area of ​​28 mN / m to 35 mN / m at 20° C. and a surface tension selected in the range of 28 mN / m to 35 mN / m at 20° C. can release between 6 mg and 13 mg of the fluid, wherein the fluid is optionally selected from the group consisting of nail polish remover, water, oil, alcohol (e.g., ethanol) and saline and / or the fluid has a viscosity selected in the range of 0.5 mPa to 200,000 mPa at 20° C.

[0315] In this regard, it should be further noted that with 57mm 2and an application tip having a surface area selected in the range of 28 mN / m to 35 mN / m at 20°C can absorb between 2 mg and 35 mg of fluid, wherein the fluid is optionally selected from the group consisting of nail polish remover, water, oil, alcohol (e.g., ethanol) and saline and / or the fluid has a viscosity selected in the range of 0.5 mPa to 200,000 mPa at 20°C.

[0316] In this regard, it should be further noted that with 57mm 2 and an application tip having a surface area of ​​28 mN / m to 35 mN / m at 20° C. and a surface tension selected in the range of 28 mN / m to 35 mN / m can release between 0.3 mg and 22 mg of the fluid, wherein the fluid is optionally selected from the group consisting of nail polish remover, water, oil, alcohol (e.g., ethanol) and saline and / or the fluid has a viscosity selected in the range of 0.5 mPa to 200,000 mPa at 20° C.

[0317] This material can be successfully used to provide an applicator that avoids trauma to the nasal cavity.

[0318] In this regard, it should be noted that the use of, for example, open-cell foam provides a foam composed primarily of interconnected pores that share some of their structure with other pores. This type of foam is softer and more flexible than closed-cell foam and allows gases and vapors to move freely through the pores and absorb liquids when immersed therein.

[0319] Other types of plastics that can be used for the applicator tip, such as HDPE and PP, provide a medical grade plastic as the applicator tip that is known to be safe for use with such applicators and that also provides an applicator tip with the desired softness and flexibility to avoid damage to the nasal cavity.

[0320] In this regard it should be noted that the application tip can have an average value of Young's modulus selected to be 0.5 kPa to 500 kPa, preferably in the range of 1 kPa to 300 kPa, in particular in the range of 5 kPa to 250 kPa, in particular in the range of 8 kPa to 10 kPa and most preferably 9.3 kPa.

[0321] Methods for measuring the softness of plastics, such as, for example, open-cell polyurethane foams, are well known and defined in ISO 527-1:2019 (en) Plastics - Determination of tensile properties.

[0322] The material hardness of the application tip may be selected in the range of 25 to 95, in particular in the range of 40 to 60, measured according to the Shore hardness scale A (eg for thermoplastic elastomers).

[0323] The material hardness of the application tip may be selected in the range of 35 to 50, in particular in the range of 40 to 48, in particular in the range of 44 to 46, measured according to the Shore hardness scale D of, for example, LDPE.

[0324] The end of the application tip may at least partially have at least one of the following shapes: a conical outer shape, an at least substantially conical outer shape, a truncated conical shape, an at least substantially truncated conical shape, a circular shape, an at least substantially circular shape, a spherical shape, an at least substantially spherical shape, an oval shape, an at least substantially oval shape, a rounded edge and a combination of the foregoing, i.e. a shape that increases in size between the end and the middle part of the application tip.

[0325] By means of such a shape, it is possible to provide an application tip which is formed complementary to the shape of the nasal cavity and thus reduces the risk of damage to the nasal cavity.

[0326] The applicator may be a 2K applicator, wherein the application tip is formed from a first material and the support is formed from a second material, optionally wherein the application tip is formed directly on the support in a two-step manufacturing process. In this way, the support can be formed to be harder than the application tip, wherein the application tip is optionally formed integrally on the support.

[0327] The application tip may be formed from high-density polyethylene, optionally sintered and having a porous volume selected in the range of 40% to 60%, preferably in the range of 45% to 55%, with a pore size in the range of 80 μm to 300 μm, in particular in the range of 100 μm to 250 μm. This sintered porous plastic material can reliably store and release fluids and is soft enough to avoid damage to the nasal cavity.

[0328] Applicator can further comprise the container that is filled with fluid (such as, liquid), wherein, application tip is configured to moisten with the liquid stored in the container, preferably, container is configured to store the fluid between 0.2ml and 200ml.In this way, the fluid to be applied can be stored in the container that is preferably sealed about environment, to provide and can store longer time period and avoid the applicator of fluid stored therein overflowing and pollution.In addition, container provides the volume that can be filled with high precision. Nasal application needs the fluid between 0.2ml and 10ml to carry out effective treatment usually, therefore providing the single use container with the filling volume of 0.2ml to 10ml is desirable, because this realizes that distributing the liquid of this amount is useful.Similarly, for the application of multiple use, it is desirable to provide the container with the filling volume selected in the range of 10ml to 200ml.

[0329] The hydrophilic properties may be taken into account during the production of the applicator foam. In this regard, the application tip may include a hydrophilic foam having a hydrophilicity ranging from 30 kg / m 3 Up to 150kg / m 3 The foam has a density of 100 μm and a porosity ranging from 60 ppi to 150 ppi. The foam is suitable for use in treating nasal decolonization.

[0330] The application tip may include a polyurethane elastomeric body containing 20 or more pores of 300 μm or less.Such foams can be used to reliably store and release fluids therefrom.

[0331] The applicator may further comprise a dispenser, wherein the support is a rod comprising a passage, and the passage is connected to or integrally formed with an outlet of the dispenser for dispensing liquid from a container of the dispenser to the application tip, so as to supply the fluid to the application tip. Providing a dispenser at the applicator enables a predetermined amount of fluid to be dispensed via the application tip in a well-defined manner.

[0332] The dispenser may include: a housing defining a longitudinal axis and having a proximal end and a distal end; a discharge device at least partially disposed within the housing and having an inlet opening within the housing and an application tip, the discharge device further defining a discharge path for the fluid extending between the inlet opening and the application tip; a holder as a container received in a proximal region of the housing and movable relative to the housing along the longitudinal axis between a starting position and a final discharge position, wherein the holder defines a receiving space adapted to be loaded with a separate container containing a quantity of fluid to be discharged; and activation means for establishing a flow connection for the fluid from the receiving space of the holder to the inlet opening of the discharge device, wherein the activation means are adapted to establish the flow connection when the holder is in or moving toward the final discharge position. Such a dispenser can be used to dispense fluids stored in separate containers in a simple and sterile manner. Furthermore, the container insertable into the holder provides a volume that can be filled with high precision. The dispenser allows for the one-time dispensing of the predefined volume, making it possible to dispense a predefined amount of material at one time, particularly when the dispenser is of a single-use design.

[0333] In the starting position, the tray may protrude from the proximal end of the housing so as to be pushable by a user further into the housing and towards the final discharge position, and / or wherein the activation means is inoperative when the tray is in the starting position.

[0334] The flow connection can be established automatically by moving the carriage towards the final discharge position and / or before the carriage reaches the final discharge position. In this way, a dispenser that is simple to handle and use can be achieved.

[0335] The dispenser may be a syringe. Such a dispenser is simple to implement, cost-effective to manufacture and easy to handle.

[0336] The syringe may comprise a plunger and a barrel in which a fluid may be stored, wherein the plunger acts on the fluid during dispensing of the fluid from the barrel via the application tip.Such a design of the syringe is simple and easy to use.

[0337] The dispenser may be an applicator device comprising: a carrier body provided with an application tip at one end and a pin at an opposite end; a transverse channel penetrating the pin; an axial channel branching off from the transverse channel and leading to the applicator device; and a reservoir device having an annular edge seal sealingly engaging the pin, whereby the applicator device is activated by displacing the reservoir device on the pin toward the applicator device to open a flow connection between the reservoir device and the transverse channel, the reservoir device having a receptacle segment that is elastically deformable in at least a plurality of portions, such that when the applicator device is activated and a flow connection exists between the transverse channel and the receptacle segment, the fluid is discharged through the application tip by manually compressing the resiliently deformable area of ​​the receptacle segment. Providing the dispenser with an elastically deformable portion that can be used to extrude the fluid from the dispenser avoids fluid overflow and permits dispensing of a predefined amount of fluid.

[0338] The rod may be a solid rod and the solid rod may be connected to the handle of the applicator.Thereby, a versatile and simple to use applicator may be provided which utilizes a well known and therefore simple to manufacture closure.

[0339] The applicator may further comprise a container, optionally filled with said fluid, wherein the application tip is stored in the container and optionally in said fluid before use of the application tip. In this way, the fluid can be stored with the applicator in a safe and secure manner.

[0340] The handle is optionally part of a closure for the container, and the application tip and rod may be insertable into or removable from the container. Thus, a versatile and easy-to-use applicator may be provided which utilizes a well-known and therefore simple-to-manufacture closure.

[0341] The handle may be releasably screwed to the container.Thereby, a versatile and simple to use applicator may be provided which utilizes a closure which is well known and therefore simple to manufacture.

[0342] The handle may be part of the support.This simplistic design is simple to manufacture and results in a cost-effective applicator.

[0343] The container may comprise a membrane, wherein the fluid is stored directly adjacent to the membrane and the application tip is stored at the other side of the membrane.

[0344] The support may include one or more seals configured to seal against an inner surface of the container.Such seals may prevent contaminants from entering the applicator and / or may prevent fluid from leaving the applicator.

[0345] The container may be a multi-part container having an inner container disposed within an outer container. The material stored in such a container may be protected from external contamination, resulting in an extended shelf life and sterile packaging of the applicator.

[0346] The fluid can be stored in the applicator and include at least one of the following substances: medical fluid, dental fluid, veterinary fluid, antiseptic substance, antihistamine, glucocorticoid, epinephrine, mast cell stabilizer, anti-leukotriene agent, povidone iodine, mupirocin, alcohol, jojoba oil, water, orange oil, lauric acid, benzalkonium chloride, vitamin E, hypothiocyanate, lactoferrin, N-chlorotaurine, interferon-alpha, povidone iodine, quaternary ammonium compound, alcohol-based nasal antiseptic, hydroxychloroquine, golden lily flower, luffa scoparia, saba, and combinations thereof.

[0347] Fluids containing such substances may be successfully used in applications for treating the nose of a human or animal, and particularly in connection with nasal decolonization. BRIEF DESCRIPTION OF THE DRAWINGS

[0348] The following drawings illustrate various embodiments of the disclosure, and together with the description serve to explain the principles and operations of the claimed subject matter:

[0349] Figure 1 is a perspective view of the discharger in a stored state;

[0350] Figure 2 In the post-discharge state Figure 1 A perspective view of an emitter;

[0351] Figure 3 is in Figure 1 A partial cross-sectional view of the discharger in a state of

[0352] Figure 4 is in Figure 2 A partial cross-sectional view of the discharger in a state of

[0353] Figure 5 It is a cross-sectional view of another type of static piston of the discharger;

[0354] Figures 6 to 8 An exhaust system including an exhauster according to the present disclosure is shown in different states of use;

[0355] Figure 9 Shown Figure 6A partial cross-section of the exhaust system along a first longitudinal axis;

[0356] Figure 10 Shown Figure 9 The enlarged part;

[0357] Figure 11 Shown Figure 8 a partial cross-section of a proximal portion of the exhaust system along a first longitudinal axis;

[0358] Figures 12 to 14 A first cross section of the puncture tip according to the present invention and a side view of the puncture tip after being rotated 90° are respectively shown;

[0359] Figure 15 A perspective view of a puncture tip having ridges is shown;

[0360] Figures 16 to 18 An exhaust system including an exhauster and a container according to the present disclosure is shown in different states of use;

[0361] Figure 19 Shown Figure 16 A cross-sectional view of the exhaust system along the longitudinal axis;

[0362] Figure 20 Shown Figure 19 The enlarged part;

[0363] Figure 21 Shown Figure 18 a cross-sectional view of a proximal portion of the exhaust system along the longitudinal axis;

[0364] Figure 22 is a schematic representation of a first embodiment of a syringe according to the present invention in a storage position;

[0365] Figure 23 is a schematic representation of the first embodiment in a released position;

[0366] Figure 24 is a schematic representation of the first embodiment in an end position after discharging the first fluid and the second fluid;

[0367] Figure 25 is a schematic representation of the first embodiment in a retracted position;

[0368] Figure 26 is a schematic representation of the second embodiment in a storage position;

[0369] Figure 27 is a schematic representation of the third embodiment in a storage position;

[0370] Figure 28is a schematic representation of the fourth embodiment in a storage position;

[0371] Figure 29 is a schematic representation of the fifth embodiment in a storage position;

[0372] Figure 30 shows a perspective view of a discharger including a container according to the present disclosure;

[0373] Figure 31 Shown Figure 1 A cross-sectional view of the discharger along the longitudinal axis;

[0374] Figure 32 Shown Figure 31 An ejector wherein the proximal portion of the intermediate section is in a final ejection position.

[0375] Figure 33 A first exemplary embodiment of a dispensing device according to the invention is shown in a perspective view;

[0376] Figure 34 Shown Figure 33 Magnified details;

[0377] Figure 35 Shown in assembled condition Figure 34 Mixing and spraying heads;

[0378] Figure 36 Shown according to Figure 35 The section along line IV-IV in

[0379] Figure 36A Shown Figure 36 Detailed view of an embodiment variant of a mixing and spraying element with a compressed air inlet,

[0380] Figure 37 Shown according to Figure 36 The section of line VV in

[0381] Figure 38 Shown according to Figure 36 The section of line VI-VI in

[0382] Figure 39 Shown according to Figure 38 The section along line VII-VII in

[0383] Figure 40 A second exemplary embodiment of a dispensing device according to the invention is shown in a perspective view,

[0384] Figure 41 Shown through Figure 40 Cross-section of the assembled mixing and spraying head,

[0385] Figure 42 Shown according to Figure 41 The section of line XX in ;

[0386] Figures 43 to 45 An applicator is shown in different states of use, formed as a discharge system comprising a dispenser and a container;

[0387] Figure 46 Shown Figure 43 A cross-sectional view of the exhaust system along the longitudinal axis;

[0388] Figure 47 Shown Figure 46 The enlarged part;

[0389] Figure 48 Shown Figure 45 a cross-sectional view of a proximal portion of the exhaust system along the longitudinal axis;

[0390] Figure 49 is a longitudinal section through a first embodiment of an applicator device as an applicator for a single-component system in a deactivated position;

[0391] Figure 50 Shown in the activated position Figure 49 The applicator device shown in FIG.

[0392] Figure 51 is a longitudinal section through a second embodiment of an applicator device as an applicator for a single-component system in a deactivated position;

[0393] Figure 52 Shown in the activated position Figure 51 The application position shown in FIG;

[0394] Figure 53 A syringe with an application tip is shown;

[0395] Figure 54 Another type of applicator is shown;

[0396] Figure 55 Yet another type of applicator is shown;

[0397] Figure 56 Still another perspective view showing another type of emitter;

[0398] Figure 57 Shown along the section line A:A through Figure 56 A schematic cross-sectional view of an emitter;

[0399] Figure 58 Shown Figure 59 A detailed view of the second end of the outer housing member of the discharger shown in FIG.

[0400] Figure 59 Shown Figure 56 Detailed view of the first end of the outer housing component of the emitter shown in .

[0401] In the following description of the drawings, further embodiments of the present invention are described. The invention will be explained in detail below by means of embodiments and with reference to the accompanying drawings, in which:

[0402] Hereinafter, the same reference numerals will be used for parts having the same or equivalent functions. Any statements made about the orientation of components are made relative to the positions shown in the drawings and may naturally vary in actual positions of application. DETAILED DESCRIPTION

[0403] The various devices described below can each be filled with a fluid F. Fluid F is a medical fluid, particularly one containing lipid nanoparticles. This fluid F is typically applied to or in the nasal cavity to protect against viral infections that are ingested by the human body. As a result, the mucous membrane is covered with a protective layer that degrades over time and provides protection from one or more viral infections to the person receiving the medical fluid treatment for the time period.

[0404] In this regard, it should be noted that the size of the lipid nanoparticles is typically selected within the range of 10 nm to 400 nm, particularly within the range of 15 nm to 200 nm. Such lipid nanoparticles can be constructed as discussed in the article "Lipid Nanoparticles Potentiate CpG-Oligodeoxynucleotide-Based Vaccine for Influenza Virus" published on January 9, 2020 in Front. Immunol. (Sec. Vaccines and Molecular Therapeutics Volume 10-2019 | https: / / doi.org / 10.3389 / fimmu.2019.03018).

[0405] It should be further noted that the lipid nanoparticles are present in a solution comprising polyethylene glycol (PEG), the concentration of which can be selected depending on the desired antibody and the desired duration of application.

[0406] It should be further noted that the lipid nanoparticles are constructed to contain antibodies against one or more viral infections, such as cold and / or flu antibodies. The composition may also include one or more antibodies against other viral infections.

[0407] Figure 1 The discharger 1 is shown in a storage state. The discharger 1 comprises a dispensing element 2, a housing 3 and a container 4. The dispensing element 2 extends between a distal end 5 and a proximal end 6 and thereby defines a longitudinal axis A of the discharger 1, wherein an outlet 7 of the discharger 1 is configured at the distal end 5. The outlet 7 can be either a simple nozzle (not shown) or a specially designed nozzle (also not shown) that enables a specific spraying action to be performed with the discharger 1.

[0408] The housing 3 has a distal region 8 and a proximal region 9, wherein the distal region 8 of the housing 3 adjoins the proximal end 6 of the dispensing element 2. The housing 3 comprises a static piston 10 arranged therein (see e.g. Figure 3 and Figure 4 ) and has wing-shaped protrusions 11 which protrude from the substantially cylindrical housing 3 in the distal region 8 of the housing 3 .

[0409] The housing 3 further comprises a cutout 15 in the distal region 8. Furthermore, a nose 34 cooperating with the cutout can be seen. The cutout 15 and the nose 34 form part of a snap-in connection, as will be explained below.

[0410] The container 4 is arranged at the proximal region 9 of the housing 3. The container 4 comprises a compartment 12 in which a fluid F is stored and which is sealed by means of a seal 13 configured as a membrane 13 (see Figure 3 ) is sealed and isolated relative to the static piston 10.

[0411] In this example, the outer wall 14 of the container 4 comprises a groove 16 having two longitudinal sections 17, 17' which are parallel to each other and offset parallel to the longitudinal axis A and connected to each other via a connecting section 18. Figure 1 In the storage state of the discharger 1 shown in FIG, a pin 19 protruding from the proximal region 9 of the housing 3 is present in the connecting section 18 .

[0412] In this example, the pin 19 is placed in the connecting section 18 of the groove 16. By placing the pin 19 in the connecting section 18 that does not extend in the direction of the longitudinal axis A, it is possible to prevent an unintentional linear displacement of the container 4 relative to the housing 3 and thereby prevent either an unintentional removal of the container 4 from the housing 3 or an unintentional movement of the container 4 toward the wing-shaped projection 11. In this way, the ejector 1 includes a child safety lock formed between the container 4 and the housing 3.

[0413] When it is desired to activate the dispenser 1, the container 4 is rotated in the direction of arrow B, so that the pin 19 is then guided into the longitudinal section 17. Once the pin 19 is in the longitudinal section 17, the container 4 can be pressed toward the wing-shaped projections 11 in the direction of the longitudinal axis A. The user can perform this pressing of the container 4 toward the wing-shaped projections 11 by placing a thumb or a different finger at the end 21 of the housing and two additional fingers at each of the wing-shaped projections 11, and then moving these fingers and / or thumbs toward each other in a clamp-like manner. The end 21 has a recess 22 formed therein to improve the placement of the fingers / thumbs at the end 21 of the container 4.

[0414] Figure 2 The container 4 is shown in a post-discharge state (ie, a state in which the user has pressed the container 4 from the proximal region 9 of the housing 3 up to the wing-shaped protrusion 11 formed at the housing 3). Figure 1 In the post-discharge state of the discharger 1, the fluid F stored in the compartment 12 has been discharged through the outlet 7 (see Figure 4 ) is discharged from the discharger 1.

[0415] Figure 3 Shown is shown as being in Figure 1 1 is a partial sectional view of the discharger 1 in the state shown in . This view shows how the static piston 10 is arranged in the housing 3 of the discharger 1. The static piston 10 is connected to the distribution element 2 in a fluid-conducting manner.

[0416] For this purpose, the static piston 10 has an inlet 23 leading to a passage (not shown) which connects the inlet 23 with the outlet 7 of the dispensing element 2. The passage thus extends through the static piston 10 and the dispensing element 2.

[0417] The ejector 1 is preferably designed so that the only way the fluid present in the container 4 can pass to the outside via the distal region 8 is via the inlet 23 and the passage, the housing 3 otherwise comprising sealing elements 25', 26', 27', 29' to seal the housing 3 towards the outside.

[0418] The static piston 10 includes a piercing tip 24 having an inlet 23 formed at one end 24″ of the piercing tip 24. The other end 24′ of the piercing tip 24 includes a first sealing lip 25 as a first sealing element 25′. A second sealing lip 26 and a third sealing lip 27 are also formed on the static piston 10 as a second sealing element 26′ and a third sealing element 27′. The first sealing lip 25, the second sealing lip 26, and the third sealing lip 27 are arranged successively and parallel to each other in the direction of the longitudinal axis A of the discharger 1. Figure 3In the storage state of the discharger 1 shown in FIG, the first sealing lip 25 , the second sealing lip 26 and the third sealing lip 27 do not contact the cylindrical wall 28 of the housing 3 .

[0419] The cylindrical wall 28 of the housing 3 comprises a sealing element 29'. In this case, the sealing element 29' is a sealing lip 29 which extends circumferentially around the inner surface 30 of the cylindrical wall 28 in the proximal region 9 of the housing 3. Figure 3 In the storage state shown in FIG, the sealing lip 29 is an inwardly protruding sealing lip 29. The sealing lip 29 protrudes in the direction of the piercing tip 24 arranged about the longitudinal axis A, and protrudes into the interior of the housing 3 without engaging any other components. This means that the sealing lip 29 faces the longitudinal axis A of the drain 1, preferably so that in the storage state of the drain 1 it neither contacts nor is connected to any other components other than the housing 3.

[0420] It should be noted that the plane including the piercing tip 24 , the inlet 23 and the end 24 ″ also includes the sealing element 29 ′. This plane is arranged perpendicular to the longitudinal axis A.

[0421] Figure 3 Also shown is a section through the container 4 of the discharger 1 in a plane perpendicular to the longitudinal axis A. Figure 1 As mentioned, the container 4 comprises a compartment 12 for containing a fluid F in a storage state. In a direction towards the end 21 of the container 4 comprising the recess 22, the compartment 12 extends from the seal formed by the membrane 13 to a puncture tip receiving end 31 (also referred to as end 31 ′ of the compartment 12).

[0422] The end 31 ' of the compartment 12, which is arranged opposite the membrane 13, is formed by the wall 41 of the compartment 12. The wall 41 converges from the wall 32 to a common point 31 '' at the end 31 ', which common point coincides with the longitudinal axis A to form the end 31 ' of the compartment 12. This means that the diameter of the compartment 12 decreases along the wall 41 from the wall 32 to the longitudinal axis A.

[0423] As also shown, end 31' of compartment 12 is set back approximately 30% of the length of outer wall 14 from rear end 21 of container 4. In this regard, it should be noted that end 31' may be set back from rear end 21 by at least 20%, in particular 25% to 45%, of the length of outer wall 14.

[0424] A further web 42 is provided in the region of the rear end 21 of the container. The further web 42 extends parallel to the outer wall 14 between the end 31 'of the compartment 12 and the rear end 21 of the container 4. This further web 42 forms a base 43 of the recess 22 at the rear end 21 and thus forms a base 43 on which a finger or thumb can advantageously rest.

[0425] The dimensions of compartment 12 define the volume of fluid F that can be stored in container 4. This means that if a smaller volume of fluid F is to be stored in compartment 12, the length L of compartment 12 can be chosen to be shorter. Consequently, if a larger volume of fluid F is to be stored in container 4, the length L of compartment 12 can be chosen to be longer than in the present case. Thus, the volume of fluid F stored in container 4 corresponds to the space of container 4.

[0426] In this connection it should be noted that a typical filling volume of the compartment 12 of the container 4 is 0.1 ml to 10 ml, preferably 0.2 ml to 5 ml.

[0427] It should be further noted that the thickness of the wall 32 of the compartment 12 is typically selected within the range of 0.7 mm to 1.5 mm, preferably within the range of 0.9 mm to 1.1 mm, and in particular is approximately 1 mm. Similarly, the thickness of the outer wall 14 of the container 4 is typically selected within the range of 0.7 mm to 1.5 mm, preferably within the range of 0.9 mm to 1.1 mm, and in particular is approximately 1 mm.

[0428] In this connection, it should be noted that the thickness of the wall 28 of the housing 3 is typically selected within the range of 0.7 mm to 1.5 mm, preferably within the range of 0.9 mm to 1.1 mm, and is in particular approximately 1 mm.

[0429] In this regard it should be noted that if a compartment 12 of greater volume is chosen, the length of the static piston 10 may also be increased in order to ensure that as much as possible of the fluid F initially stored in the compartment 12 is discharged from the discharger 1 .

[0430] In the previously described embodiment, the compartment 12 is formed integrally with the container 4, i.e., the container is a single-part container 4. In a further embodiment, a separate compartment in the form of a carrier with a predefined volume (not shown) can be used to form a two-part or multi-part container (also not shown). The sealing elements 25', 26', 27' are then configured to interact with the inner surface of the multi-part container (i.e., with the inner surface of the carrier).

[0431] It should further be noted that the length L of the compartment 12 is defined as the distance between the membrane 13 and the puncture tip receiving end 31 .

[0432] The shape of the piercing tip receiving end 31 is selected to be complementary to the shape of the piercing tip 24. This is because, when discharging the fluid F stored in the compartment 12 of the container 4, it is desirable that the residue of the fluid F is as small as possible, preferably so that once the discharger is in Figure 4 In the post-discharge state shown in FIG, all the fluid F stored in the container 4 is discharged.

[0433] like Figure 3As also shown in FIG, the container 4 is a double-walled container comprising an inner wall 32 and an outer wall 14 separated by a preferably annular guide groove 33. The inner wall 32 forms the wall of the compartment 12. The guide groove 33 can also be referred to as an annular gap formed between the inner wall 32 and the outer wall 14 of the double-walled container. In this regard, it should be noted that the at least one groove 16 extends from the guide groove 33 to the outer surface 14″ of the outer wall 14. Preferably, the inner wall 32 and the outer wall 14 are injection molded as one piece during the manufacture of the container 4, wherein a connecting web 40 is also formed during the injection molding process, which connects the inner wall 32 to the outer wall 14 at the end 40 ′ of the guide groove 33.

[0434] In this connection it should be noted that the length or depth of the guide groove 33 on the longitudinal axis A of the discharger 1 is Figure 3 Approximately 90% of the length of the outer wall 14 of the discharger 1. It should further be noted that the length of the guide groove 33 can be selected to correspond to 50% to 95% of the length of the outer wall 14.

[0435] In the present example, the membrane 13 also forms the front end 13'' of the compartment 12 and thus the front end 13'' of the inner wall 32. The membrane 13 not only forms the front end of the compartment 12, but also defines the front end of the double-barreled container 4, since the plane 13' including the membrane 13 defines said front end. Thus, in addition to the membrane 13, the plane 13' also includes the end 14' of the outer wall 14 and the end 32' of the wall 32. The double-barreled container 4 thus extends from the membrane 13 to the end 21 (i.e. the rear end 21), which has the recess 22 formed therein.

[0436] In this regard it is noted that the opening 33 ′ of the groove is arranged at the front end 13 ″′ of the container, ie the groove 33 is open towards the housing 3 in order to receive the cylindrical wall 28 at the front end 13 ″′ of the container.

[0437] exist Figure 3 In the storage state of the ejector 1 shown in FIG, the front end of the compartment 12 is received in the housing 3, while the outer wall 14 of the double-barreled container 4 surrounds the cylindrical wall 28 of the housing in the proximal region 9 of the housing 3. This means that the front end of the container 4 is configured to receive at least the proximal region 9 of the housing 3.

[0438] Figure 3 The section through the container 4 also shows the presence of a second pin 19 ′ at the other side of the housing 3 . This second pin 19 ′ also cooperates with a second slot (not shown) similar to the slot 16 present in the double-walled container 4 .

[0439] In the present case, the first pin 19 and the second pin 19' are arranged at 180° relative to each other at the outer surface 28' of the housing 3. In practice, such dispensers are possible, i.e., they utilize only one pin and slot arrangement or also utilize more than two pin and slot arrangements. It is also conceivable that the pins are not arranged at 180° relative to each other at the outer surface 28' of the housing 3, but are arranged at different angles, thereby ensuring the correct alignment of the container 4 relative to the housing 3. As can be seen from Figure 3 It can further be seen that the pins 19 , 19 ′ are set back from the end 39 of the housing 3 located in the proximal region 9 .

[0440] When assembling the ejector 1, the different components are connected to each other. In this regard, it should be noted that in the preferred design of the ejector 1, the static piston 10 and the dispensing element 2 are preferably injection-molded as one piece in a common mold. Alternatively, an overmolding process can also be used.

[0441] Alternatively, the individual components of the ejector 1 (e.g., the dispensing element 2, the housing 3, the container 4, the static piston 10) can also be formed separately and then assembled, e.g., the static piston 10 and the dispensing element 2 can be connected to each other via a Luer lock connection (in this regard, see e.g., Figure 5 ).

[0442] In this regard it should be noted that the components of the emitter may be formed from polymeric materials such as PE (polyethylene), PP (polypropylene) and COC (cyclic olefin copolymer).

[0443] For example, the container 4 may be formed from a polymer material such as COC.

[0444] In this connection it should also be noted that, like the assembly comprising the static piston 10 and the dispensing element 2 , the housing 3 and the container 4 can also be formed as separate parts in a specially designed mold (not shown) in an injection molding process.

[0445] The assembly comprising the static piston 10 and the dispensing element 2 is then inserted into the housing 3 via the distal region of the housing 3. The assembly comprising the static piston 10 and the dispensing element 2 is fixed to the inner surface 30 of the housing 3 via a snap-in connection, which in this respect is formed by a nose 34 which engages with the cutout 15 present in the cut-away section of the housing 3 (see FIG. Figure 1 ) There is also a second snap-in connection on the other side of the housing 3 , which cannot be seen in the depicted section.

[0446] On the other hand, the assembly comprising the static piston 10 and the dispensing element 2 is fixed to the inner surface 30 of the housing 3 by means of a press fit. For this purpose, three rings 35 are provided at the assembly comprising the static piston 10 and the dispensing element 2. In addition to ensuring the press fit, these three rings 35 also ensure the correct parallel orientation of the static piston 10 within the housing 3, i.e. the static piston 10 is not inserted into the housing 3 at an oblique angle.

[0447] In this connection it should be noted that the three rings 35 which provide for the correct orientation of the static piston 10 relative to the housing 3 can also be formed by only one or two larger rings (not shown).

[0448] When the container 4 is assembled at the housing 3, the cylindrical wall 28 of the proximal region 9 of the housing 3 is inserted into the groove 33 of the container 4. By aligning the pin 19 of the housing 3 with the longitudinal section 17' of the container 4, the guidance of the container 4 relative to the housing 3 is further improved.

[0449] The container 4 is then first moved in the direction of the longitudinal axis A in the direction of the wing-shaped projections 11 by guiding the cylindrical wall 28 of the proximal region 9 of the housing 3 in a linear manner in the groove 33. As soon as the pins 19, 19' have reached the end of the respective longitudinal section 17', they are moved in the direction of the arrow B (see Figure 1 ) so that the pin 19 is received in the connecting section 18 and stored there, i.e. the child safety lock of the drain 1 is activated. This means that after the drain 1 has been rotated, the child lock is activated by means of radial displacement and the drain 1 reaches its storage state.

[0450] After the discharger 1 shifts to the discharge state and then reaches Figure 4 13 (post-discharge state), the piercing tip 24 exerts a substantially uniform pressure on the membrane 13, causing the membrane to initially deflect and then be uniformly pierced starting from the center of the membrane 13 radially outwards, and then allowing the fluid F stored in the compartment 12 to directly reach the inlet 23 present in the piercing tip 24 located in the area where the piercing of the membrane 13 begins. Due to the pressure increase in the compartment 12 when the container 4 is pressed towards the wing-shaped projection 11, the fluid F is discharged from the dispensing element 2 via the inlet 23, the passage and the outlet 7.

[0451] When the container 4 moves towards the wing-shaped projection 11 in the direction of the longitudinal axis A, the container 4 is linearly guided relative to the housing 3. This guidance is brought about by the interaction between the cylindrical wall 28, the guide groove 33 and the inner wall 32 and the outer wall 14 of the container 4.

[0452] Furthermore, after piercing the membrane 13 and during further guidance of the cylindrical wall 28 towards the wing-shaped projection 11 relative to the guide groove 33 and the inner wall 32 and outer wall 14 of the container 4, the sealing lip 29 present at the inner surface 30 of the housing 3 is brought into engagement with the outer surface 36 of the inner wall 32 of the double-walled container 4. By means of the engagement of the sealing lip 29 at the outer surface 36, a seal is formed between the proximal region 9 of the housing and the container 4. This seal thus forms a barrier to fluid F escaping from the housing 3 in the proximal region 9 (i.e., via the guide groove 33 and the groove 16).

[0453] The sealing lip 29 is thus configured to engage only the outer surface 36 of the inner wall 32 once the piercing tip 24 contacts the membrane 13. The sealing lip 29 remains in contact with the outer surface 36 of the inner wall 32 even after the piercing tip 14 has moved past the initial position of the membrane 13 toward the piercing tip receiving end 31.

[0454] In order to ensure that the sealing element 29 ′ of the housing 3 engages the wall 32 of the container 4 , a portion of the container 4 , preferably a portion of the wall 32 of the container 4 , is received within the housing 3 .

[0455] As the container 4 moves further in the direction of the longitudinal axis A, the inner surface 37 of the compartment 12 of the double-walled container 4 is initially brought into contact with the first sealing lip 25. As the container 4 moves further in the direction of the longitudinal axis A, the inner surface 37 comes into contact with the second sealing lip 26 and then with the third sealing lip 27. The sealing lips 25, 26, 27 thus provide a seal between the static mixer 10 and the inner wall 32 of the compartment 12 of the container 4. This seal prevents the fluid F from reaching the space 38 provided between the piercing tip 24 and the first of the three rings 35 and thereby passing into a portion of the housing 3 at the distal region 8 of the housing 3.

[0456] A side effect of the pressure increase of the fluid F before discharge is that, in particular with respect to viscous fluids such as Fluorine, the fluid F can leak between the inlet 23 and the membrane 13, causing it to flow along the puncture tip 24 and towards the distal region 8 of the housing 3. By providing sealing elements 25', 26', 27' between the puncture tip 24 and the inner surface 37 of the compartment, this movement of the fluid F into the distal region 8 of the housing 3 is avoided.

[0457] As from Figure 4 As can be seen from the partial cross-sectional view, the first sealing lip 25, the second sealing lip 26 and the third sealing lip 27 are in contact with the inner surface 37 of the compartment 12, thereby ensuring that no fluid F can be transferred from the compartment 12 via the puncture tip 24 and the first sealing lip 25, the second sealing lip 26 and the third sealing lip 27.

[0458] Figure 5A section through another type of static piston 10 is shown with a piercing tip 24. In this section, it can be seen that the diameter of the first sealing element 25' is smaller than the diameters of the second sealing element 26' and the third sealing element 27'. The diameters of the second sealing element 26' and the third sealing element 27' are at least substantially the same.

[0459] In this regard, it should be noted that the outer diameter of the second sealing element 26' and the third sealing element 27' is greater than the inner diameter of the compartment 12. By way of example, the outer diameter of the second sealing element 26' and the third sealing element 27' is selected to be 0.01 mm to 0.2 mm greater than the inner diameter of the compartment 12 of the container 4, preferably, the outer diameter of the second sealing element 26' and the third sealing element 27' is selected to be 0.05 mm to 0.15 mm greater than the inner diameter of the compartment 12 of the container 4.

[0460] It should be further noted that the outer diameter of the first sealing element 25' is smaller than or equal to the inner diameter of the compartment 12. For example, the outer diameter of the first sealing element 25' is selected to be 0.00 mm to 0.2 mm smaller than the inner diameter of the compartment 12 of the container 4, and preferably, the outer diameter of the first sealing element 25' is selected to be 0.02 mm to 0.10 mm smaller than the inner diameter of the compartment 12 of the container 4.

[0461] During use of the static piston 10, the first sealing element 25' then pushes the pierced membrane 13 into the compartment 12 and initially creates a seal between the membrane 13 and the first sealing element 25'. In this way, the first sealing element clears the way for the second sealing element 26' and the third sealing element 27' in order to ensure the best possible seal between the inner surface 37 of the wall 32 of the compartment 12 and the piercing tip 24.

[0462] By forming the second sealing element 26' and the third sealing element 27' slightly larger than the inner diameter of the compartment 12, the second sealing element 26' and the third sealing element 27' are compressed when introduced into the compartment 12 so as to ensure the best possible seal between the inner surface 37 of the wall 32 of the compartment 12 and the puncture tip 24.

[0463] The axial distance (gap) between the second sealing element 26 ′ and the third sealing element 27 ′ is selected to be in the range of 0.7 mm to 2 mm, and in the present example the axial distance amounts to 1 mm.

[0464] exist Figure 5 The cross section of the second sealing element 26 ′ and the third sealing element 27 ′ in the plane of the section shown in FIG shows that these are formed as circumferentially extending sealing lips 26 , 27 in a substantially triangular configuration protruding from the central section 10 ′ of the static piston 10 . The central section 10 ′ extends around the longitudinal axis A.

[0465] In contrast thereto, the first sealing element 25 ′ is formed as a circumferentially extending sealing lip 25 at an end 24 ′ of the piercing tip 24 , which is remote from the end 24 ″ comprising the inlet 23 . The end 24 ′ tapers from the sealing lip 25 towards the central section 10 ′.

[0466] A Luer lock-type connection 20 is formed at the end 23' of the static piston 10 remote from the inlet 23. This Luer lock-type connection 20 can be used to connect dispensing elements 2 of various kinds (not shown) to the static piston 10 in a simple manner.

[0467] In this connection it should be noted that the connection between the dispensing element 2 and the static piston 10 can also be formed using different types of connection pieces other than a Luer cone, such as Figure 5 Luer lock, or as discussed above Figure 3 and Figure 4 For example, a bayonet-type connection or a simple threaded connection can also be provided as various forms of connection between the dispensing element 2 and the static piston 10.

[0468] It should further be noted that the dispensing element 2 may be formed from various components, such as Figure 3 and Figure 4 a syringe-type dispensing element, such as a needle; a dropper-type dispensing element, such as a simple tube (not shown) having an orifice formed at its distal end, the orifice optionally being surrounded by a thickened portion to, for example, prevent suturing; and the like can be used as the dispensing element 2.

[0469] In combination Figure 3 and 4 The static piston 10 shown and discussed can naturally be combined with Figure 5 The dimensions, sizes and shapes of the first sealing element 25 ′, the second sealing element 26 ′ and the third sealing element 27 ′ are discussed.

[0470] In this regard, it should be noted that the first sealing lip 25, the second sealing lip 26 and the third sealing lip 27 are various forms of sealing elements 25', 26', 27', and different types of sealing elements 25', 26', 27' other than the first sealing lip 25, the second sealing lip 26 and the third sealing lip 27 can also be used as long as they provide the desired sealing function in this area of ​​the discharger 1.

[0471] As from Figure 4It can further be seen that the fourth sealing lip 29, which is designed to engage the outer surface 36 of the inner wall 32 of the double-walled container 4 in order to form a seal against the fluid F in this region, is compressed to such an extent that it is no longer visible. On the one hand, this degree of compression is necessary to ensure a seal in this region, and on the other hand, this degree of compression enables the cylindrical wall 28 to be reliably guided within the groove 33. The fourth sealing lip 29 is provided in order to ensure that if the fluid F were to pass through the first sealing lip 25, the second sealing lip 26 and the third sealing lip 27, no fluid could escape from the discharger 1 between the housing 3 and the container 4.

[0472] The guide groove 33 is provided at the double-walled container 4 so as to receive at least a portion of the housing 3, preferably a portion of the cylindrical wall 28 of the housing 3. In this way, it is possible to ensure that the container 4 is reliably guided relative to the housing 3 (and more specifically, relative to the puncture tip 24) so ​​as to guarantee that the various sealing elements 25', 26', 27', 29' (e.g., the sealing lips 25, 26, 27 and 29, etc.) engage in a uniform manner, thereby preventing liquid from leaking from the container 4 into a portion of the housing 3 or to the outside in an undesirable manner.

[0473] In this regard, it should be noted that the sealing elements 25', 26', 27', 29' can either be formed integrally and / or fixedly connected to the corresponding parts of the housing 3. Alternatively, they can be formed by separate sealing elements (not shown), such as O-rings, which are then arranged at the corresponding positions (for example, in specially provided grooves (also not shown)).

[0474] Improved guidance is achieved by forming the width of the guide groove 33 slightly wider than the thickness of the cylindrical wall 28 of the housing 3 in such a way that the cylindrical wall 28 is movably received in the guide groove 33 with enough clearance for movement, but the clearance is not so great that there is a clearance between the housing 3 and the container 4 allowing these components to become deflected relative to each other.

[0475] It should be noted in this connection that the gap between the guide groove 33 and the cylindrical wall of the housing 3 is preferably selected to be 0.1 mm on both sides of the cylindrical wall 28 of the housing 3 .

[0476] However, the gap may be chosen to be 0 mm on one side of the cylindrical wall 28 of the housing 3 and 0.1 mm on the other side of the cylindrical wall 28. This varying gap at both sides of the cylindrical wall may be due to the material choice for the cylindrical wall 28 of the housing 3 or for one of the walls 32, 14 of the container 4 that interacts with the cylindrical wall 28 of the housing 3.

[0477] In the example shown, the length of the guide groove 33 corresponds to the length of the cylindrical wall 28 from the wing-shaped projection 11 to the end 39 in the proximal region 9 of the housing 3. Furthermore, the length of the guide groove 33 corresponds approximately to the length of the inner wall 32 of the container 4. The outer wall 14 of the container 4 is longer than the inner wall 32.

[0478] The length L of the compartment 12 formed in the inner wall 32 is shorter than the length of the inner wall 32. The depth of the puncture tip receiving end 31 of the compartment 12 corresponds to approximately 20% to 30% of the length L of the compartment 12.

[0479] like Figure 4 As also shown in FIG, the wing-shaped projections 11 of the housing 3 do not contact the outer wall 14 of the container 4. This is because the wing-shaped projections 11 are arranged at a height of the housing 3 relative to the longitudinal axis A such that the static piston 10 can come to rest at the end of the compartment 12 of the container 4, and therefore the point of interaction between the static piston 10 and the piercing tip receiving end 31 defines the stop for the container 4 and not the wing-shaped projections 11.

[0480] Generally speaking, the dispenser 1 and container 4 described herein are manually operable dispensers and containers that are held in the user's hand. They are generally designed to store and / or administer a single dose of a fluid F, such as a medicine, a drug, or other type of preparation for the care of humans or animals. The single dose can be administered in one, two, or several steps, for example, if the fluid F is to be administered into the eyes or nostrils of a patient or animal.

[0481] Figure 6 The ejector 110 is shown and includes a housing 112, a bracket 126, and a discharge section 118. The housing 112 defines a longitudinal first axis A1 and is provided with opposing wing-like projections 144, similar to conventional disposable syringes. The bracket 126 is received in the proximal region 114 of the housing 112. The bracket 126 defines a receiving space 128 into which a container 134 has been loaded through an opening 35 of the bracket 126. The ejector 110 and the container 134 form a discharge system and are generally designed as disposable items intended for single use only.

[0482] The discharge section 118 of the discharger 110 includes a discharge passage 120 and extends from within the housing 112 through the tapered distal end 116 toward a thickened distal portion 117. The distal portion 117 can be integrally formed with the discharge passage 120 or can be made as a separate component that is connected to the discharge passage 120 in a suitable manner. In addition, the distal portion 117 defines an outlet opening 124.

[0483] In general, the distal portion 117 can be adapted to the type and site of application and can be in the form of or include a spray tip, a needle (cannula), a brush, a sponge, or a pipette. For large area applications, for example, a spray tip or sponge may be advantageous, while selective applications may require a needle or a small diameter evacuated tube.

[0484] The discharger 110 has a fixing means 148 comprising a slot 147 formed in the housing 112 and cooperating with a pin 146 formed at the bracket 126. The slot 147 is divided into a circumferential portion 149a and a longitudinal portion 149b extending parallel to the first axis A1.

[0485] Figure 6 The ejector 110 in FIG. 1 is shown in an initial use state, wherein the pin 146 is located at the end of the circumferential portion 149a of the slot 147. In this initial use state, the bracket 126 is prevented from moving along the longitudinal axis A1 toward the distal end 116.

[0486] Figure 7 The ejector 110 is shown in a starting position, wherein the pin 146 is located at the intersection of the circumferential portion 149a and the longitudinal portion 149b of the slot 147. In this state, the bracket 126 is movable toward the distal end 116 along the longitudinal axis A1.

[0487] Figure 8 The discharger 110 is shown in a final discharge position, wherein the pin 146 is located at the end of the longitudinal portion 149b of the slot 147. In this state, the bracket 126 is completely located inside the housing 112.

[0488] Figure 9 The partial section along the longitudinal first axis A1 shows Figure 6 However, the discharge section 118 is not shown in cross section.

[0489] Figure 9 The container 134 is shown inside the receiving space 128 of the bracket 126. The container 134 is made as a capsule having a cylindrical outer shape and is filled with the fluid 111 to be discharged. The fluid 111 inside the container 134 is located in a fluid reservoir 141 which is protected from the environment by a breakable seal 142 in the form of a foil. Figure 9 This becomes even more apparent in the enlarged portion of FIG. 141. The amount of fluid 111 inside the fluid reservoir 141 is approximately 0.5 ml. When the container 134 is loaded into the receiving space 128 of the bracket 126, the circumferential shoulder 129 of the bracket 126 acts as an axial stop for the container.

[0490] also, Figure 9The cannula portion 113 is shown as being integrally formed with the housing 112. The discharge passage 120 fits into the cannula portion 113. The proximal end portion 115 of the cannula portion 113 fits into the distal cylindrical portion 121 of the bracket 126 through the distal opening of the bracket. The housing 112 generally has a cylindrical outer shape with a constant inner diameter. In order to conform the distal cylindrical portion 121 (which has an outer diameter smaller than the inner diameter of the housing 112) to the inner diameter of the housing 112, a flange 127 is integrally formed with the distal cylindrical portion 121.

[0491] The proximal end portion 115 of the cannula portion 113 includes a piercing tip 130 having a flow channel 132 connected to the inlet opening 122 of the exhaust passage 120. The piercing tip 130 is integrally formed with the cannula portion 113 of the housing 112 and defines a centrally extending longitudinal second axis A2, which in this embodiment corresponds to the first axis A1.

[0492] from Figure 5 It becomes apparent that the flow channel 132 extends along the longitudinal first axis A1 or the longitudinal second axis A2. Furthermore, the configuration of the puncture tip 130 becomes clear. The puncture tip 130 has a convexly curved outer surface 131 and further comprises two protrusions 140, each adjacent to the flow channel 132. The protrusions originate from a ridge 139 that has been interrupted by the flow channel 132 during the manufacturing process (see FIG. Figure 15 ).

[0493] Figure 10 It is further revealed that the fluid reservoir 141 has a rotationally symmetrical inner contour 138. With the exception of the protrusion 140, the inner contour 138 is complementary to the outer shape of the piercing tip 130.

[0494] Figure 11 The discharger 110 is shown in its final discharge position, i.e., the bracket 126 has been completely moved into the housing 112 towards the distal end 116. In this position, the piercing tip 130 and at least the proximal portion 115 of the cannula portion 113 are located in the fluid reservoir 141 of the container 134. The seal 142 has been pierced and the fluid 111 has been discharged. The protrusion 140 has been compressed, so that the piercing tip 130 and the inner contour 138 of the fluid reservoir 141 establish a positive connection.

[0495] Figure 12 Shown Figures 9 to 11Detailed view of the puncture tip 130. The upper pane contains cross-sections along the longitudinal second axis A2 and along the two protrusions 140. The two protrusions 140 are positioned adjacent to the proximal entry opening of the centrally located flow channel 132. The shape of the puncture tip 130 is defined by two axially symmetrical surface lines 133a, 133b. Each surface line 133a, 133b consists of three segments S1, S2, S3, wherein each segment S1, S2, S3 is defined by a radius of curvature R1, R2, R3. This means that each segment S1, S2, S3 is a segment of a circle. The lengths of the radii of curvature R1, R2, R3 are indicated by the corresponding arrows. The radius R1 of the first segment S1 is roughly one-fifth of the radius R2 of the second segment S2. The length of the radius R2 of the second segment S2 exceeds the diameter D of the puncture tip 130 at its widest point. W The third segment S3 specifically defines the shape of the protrusion 140. The length of the corresponding radius R3 is approximately half of the radius R1. Therefore, the convex shape of the puncture tip 130 is mainly defined by the segments S1 and S2.

[0496] Figure 12 The lower panel shows a side view of the puncture tip 130 shown in the upper panel, rotated 90°. Segments S1, S2, and S3 are indicated by straight lines perpendicular to the second axis A2. It is clearly visible that the surface lines defining segment S3 extend linearly in this view and intersect at an angle α of approximately 90°. Consequently, the protrusion 140 has a triangular outline in this view.

[0497] Figure 15 It also shows a clear indication according to Figures 4 to 7 A perspective view of the convex shape of the outer surface of the puncture tip 130.

[0498] Figure 13 In the upper panel, a cross section along the longitudinal second axis A2 of another embodiment of a puncture tip 130 according to the present invention is shown. Each surface line 133a, 133b consists of two segments S1, S2, each of which is a segment of a circle with a corresponding radius R1, R2. With respect to the length of the radii R1, R2, the following applies: Figure 12 Same description as .

[0499] Flow channel 132 is not centrally located within piercing tip 130, but rather is positioned offset relative to second axis A2. This means that piercing tip 130 deviates slightly from a rotationally symmetrical configuration. Due to this arrangement, piercing tip 130 includes a spike 143, which, however, is no longer visible in the side view after a 90° rotation, as depicted in the lower panel of FIG. 62 . This configuration reduces the initial piercing force required to pierce seal 142, however, the piercing force does not reach the same level as in the embodiment including two spikes 140.

[0500] Figure 14 The upper panel shows a cross section along the second longitudinal axis A2 of another embodiment of a puncture tip 130 according to the present invention. The puncture tip 130 is rotationally symmetrical about the second axis A2, because the flow channel 132 is centrally located within the puncture tip 130. Each surface line 133a, 133b consists of two segments S1, S2, each of which is a segment of a circle with a corresponding radius R1, R2. With respect to the length of the radii R1, R2, the same as with respect to the length of the puncture tip 130 is applicable. Figure 12 and Figure 13 Same description as .

[0501] Two representations ( Figure 14 The cross-section in the upper panel and the side view after rotation by 90° in the lower panel (both indicate that the puncture tip 130 is slightly cut due to the arrangement of the flow channel 132. Therefore, the vertex of the puncture tip 130 is the imaginary point at which the two surface lines 133a, 133b would intersect if they were not interrupted by the flow channel 132.

[0502] according to Figures 12 to 13 Any of the three puncture tips can initially puncture the foil with a moderate and user-friendly puncture force, wherein the puncture tip comprising two protrusions 140 has shown the best results in this respect. However, the convex curved configuration is primarily responsible for the fact that the force that needs to be applied during the movement or displacement of the puncture tip remains substantially constant over a wide distance. This constant force distribution is caused by the Figures 12 to 14 All three puncture tips are shown and can therefore be considered independent of the shape in a relatively small area of ​​the puncture tip apex. Particularly advantageously, it is thus possible to ensure a highly homogeneous discharge by simply adapting the shape in the apex area of ​​the puncture tip to the properties of the applied foil.

[0503] In order to operate the ejector 110 (i.e., to discharge the fluid 111 inside the container 134 from the outlet opening 124 through the discharge passage 120), the bracket 126 including the container 134 needs to be pushed into the housing 112 toward the distal end 116. However, the fixing device 148 prevents the bracket 126 from being accidentally pushed into the housing 112 when the ejector is in the initial use state. Figure 6 、 Figure 9 and Figure 10 In this initial use state shown in FIG, the piercing tip 130 is still positioned spaced apart from the seal 142 of the container 134 , ie, the piercing tip 130 does not yet protrude into the fluid reservoir 141 of the container 134 .

[0504] To discharge fluid 111, the user must first intentionally rotate bracket 126 counterclockwise relative to housing 112 until pin 146 aligns with axial portion 149b of slot 147. To facilitate rotation of bracket 126, the outer surface of bracket 126 may be roughened or provided with longitudinal grooves to provide a no-slip surface.

[0505] The carriage 126, now in its starting position, can be moved along the longitudinal axis A1. From this starting position, the carriage 126 and container 134 can be actuated together like a button. The user can press the carriage and container with their thumb while counteracting this actuation by gripping the housing 112 with two fingers behind the protrusion 144. Therefore, to discharge the fluid 111, the user must then intentionally push the carriage 126 toward the distal end 116. As the carriage 126 moves toward the distal end 116, the puncture tip 130 initially punctures and then penetrates the seal 142. The puncture tip 130 enters the fluid reservoir 141 of the container 134, thereby forcing the fluid 111 out of the container 134 through the flow channel 132 connected to the discharge passage 120. The complementary shapes of the puncture tip 130 and the inner contour 138 of the fluid reservoir 141 ensure that substantially no residual amount of fluid 111 remains within the container 134.

[0506] Since relevant regulations in many countries prohibit simply throwing away medical, dental or veterinary substances, the absence of large residual fluid quantities as provided by the drain system as described herein simplifies the disposal of used containers and drains in accordance with the respective national regulations.

[0507] exist Figures 16 to 21 In the embodiment shown in , the discharge system comprises a discharger 210 into which a separate container 225 having a generally cylindrical outer shape can be loaded.

[0508] Although other devices are possible, in the embodiment shown, the drain 210 is intended for use in the medical, dental or veterinary fields and is used, in practice, to drain a predetermined amount of fluid 227 ( Figure 19 ). The fluid to be discharged is a liquid comprising one or more medical, dental or veterinary agents.

[0509] The drain and container are designed as disposable items intended for single use only.

[0510] The container 225 is made into a capsule having a generally cylindrical outer shape. The container 225 includes a wall portion 241 ( Figure 20 ), the wall portion having an integral proximal portion providing a proximal face and an opening at the distal end, the opening being closed by a rupturable seal 231 in the form of a foil. The wall portion 241 and the seal 231 define a fluid space of the container, which is at least partially filled with a fluid 227. The amount of fluid is, for example, 0.5 ml.

[0511] In such Figure 16 In the ready-to-use state shown in FIG, the container 225 has been loaded into the bracket 221 of the ejector 210. In order to be loaded into the bracket 225, the container 225 is slid through the proximal insertion opening 233 of the bracket 221.

[0512] The bracket 221 is received in the proximal region of the housing 211, which is provided with wing-shaped protrusions 227 extending in opposite directions, as in a conventional disposable syringe. In addition, a groove 243b is formed in the housing 211, which cooperates with a pin 243a formed at the bracket 221 to form a fixing means, which will be explained in more detail later.

[0513] The discharger 210 further includes a discharge device 215, Figures 16 to 18 The pipe 253 from the discharge device is shown ( Figure 19 ), which extends from the inside of the housing 211 toward the thickened distal portion 255 ( Figure 19 The end portion 255 may be integral with the tube 253 or be made as a separate component connected to the tube 253 in a suitable manner.

[0514] The drainer 210 is adapted to drain the fluid 227 inside the container 225 through the drain device 215 simply by pushing the bracket 221 including the container 225 into the housing 211. This process is incorporated elsewhere Figures 4 to 6 Described.

[0515] The fixing means 243a, 243b prevent the bracket 221 from being pushed into the housing 211 unintentionally. Figure 16In the initial condition shown in FIG, the pin 243a of the bracket 221 is located at the end of the circumferential portion of the slot 243b ( Figure 17 This condition prohibits the bracket 221 from moving along the longitudinal axis 213 of the discharger 210 ( Figure 20 )move.

[0516] To discharge the fluid, the user must intentionally rotate the bracket 221 relative to the housing 211 to align the pin 243a with the axial portion of the slot 243b ( Figure 17 In order to facilitate the rotation of the bracket 221 , a longitudinal groove 222 is provided on the outer wall of the bracket 221 .

[0517] exist Figure 17 , the bracket 221 is in a starting position and is ready to be pushed into the housing 211 .

[0518] Figure 18 The tray 221 is shown in a final discharge position in which the tray 221 and thus the loaded container 225 are completely received within the shell 211 , with the proximal surfaces of the tray 221 and the container 225 flush with the proximal surface of the shell 211 .

[0519] from Figures 16 to 18 It can be seen that the tray 221 and container 225 together can be actuated like a button, with the user pressing the tray and container with his or her thumb while counteracting the push by gripping the housing with two fingers behind the protrusion 247.

[0520] like Figure 19 As shown in FIG, the discharge device 215 includes a sleeve portion 257 formed integrally with the housing 211 and arranged inside the housing 211. Further, the discharge device 215 includes the above-mentioned pipe 253 fitted into the sleeve portion 257.

[0521] The proximal portion 235 of the discharge device 215 ( Figure 20 ) is assembled into the distal cylindrical portion 221b of the bracket through the distal opening 237 of the bracket 221. The proximal portion 235 includes an inlet opening 217 at the proximal end of the tube 253, an inlet passage 218 formed at the proximal end of the sleeve portion 257, and a tip 251 ( Figure 20 ) of the activation device 229 ( Figure 19 ), the tip being formed by a correspondingly tapered portion of the proximal end of the cannula portion 257. Figure 19 In the initial condition shown in the figure, the tip 251 is still positioned to be spaced apart from the seal 231 of the container 225, that is, the activation device 229 including the tip 251 has not yet protruded into the proximal cylindrical portion 221a of the bracket 221, which defines the receiving space 223 of the bracket 221 for the container 225.

[0522] An axial portion of the inlet passage 218 extends offset from the longitudinal axis 213 and opens into a radial portion of the inlet passage 218 that opens into the inlet opening 217 of the tube 253 .

[0523] A discharge passage extending through the tube 253 connects the inlet opening 217 with an outlet opening 219 ( Figure 19 )connect.

[0524] As especially in Figure 19 and Figure 21 As can be seen in FIG, the housing 211 generally has a cylindrical outer shape with a constant inner diameter that is equal to the outer diameter of the proximal cylindrical portion 221a of the bracket 221. In order to also conform the distal cylindrical portion 221b (which has an outer diameter smaller than that of the proximal cylindrical portion 221a) to the inner diameter of the housing 211, a flange 249 is formed integrally with the distal cylindrical portion 221b.

[0525] Furthermore, the thickness of the wall portion 241 of the container 225 corresponds to the difference between the inner diameters of the cylindrical portions 221a, 221b of the holder 221. Thus, the container 225 reduces the inner diameter of the proximal cylindrical portion 221a to the inner diameter of the distal cylindrical portion 221b, thereby establishing an inner space of the holder 221 having a constant inner diameter that corresponds to the outer diameter of the proximal end portion 235 of the discharge device 215.

[0526] This dimensioning of the various components of the discharge system ensures a mechanically reliable mutual guidance of the various components when the carrier 221, including the container 225, is inserted into the housing. Specifically, the carrier 221 is guided by the inner wall of the housing 211 through its flange 249 and its proximal cylindrical portion 221a. Furthermore, the carrier 221 is guided by the discharge device 215.

[0527] Furthermore, the design of the various components as explained above minimizes the required outer dimensions of the discharger 210, in particular the outer diameter of the housing 211. Figure 21 As can be seen in FIG, there is no unused space inside the housing 211. When the rack 221 including the container 225 is in the final discharge position, all components are concentrically packed within the housing 211.

[0528] The transition portion 221 c of the carrier 221 between the proximal cylindrical portion 221 a and the distal cylindrical portion 221 b is formed as a circumferential shoulder that serves as an axial stop for the container 225 when the container is loaded into the carrier 221. The axial distance between the proximal end surface of the proximal cylindrical portion 221 a and the transition portion 221 c corresponds to the axial length of the container 225.

[0529] The outer shape of the tapered proximal end of the discharge device 215 corresponds to the proximal section 245 of the inner wall of the container 225, so that when the bracket 221 including the container 225 is in its final post-discharge position, almost no free space is left inside the container 225, as shown in FIG. Figure 21 Thus, the complementary shapes of the discharge device 215 and the container 225 ensure that almost no residual amount of fluid is left in the container 225.

[0530] Since relevant regulations in many countries prohibit simply throwing away medical, dental or veterinary substances, the absence of large residual fluid quantities as provided by the drain system as described herein simplifies the disposal of used containers and drains in accordance with the respective national regulations.

[0531] In operation, Figure 16 In the initial state shown in FIG, the fixing means 243 a, 243 b prevent the bracket 221 from being accidentally pushed into the housing 211.

[0532] In order to discharge the fluid contained in the container 225 (which has been previously loaded into the bracket 221), the user must rotate the bracket 221 so that the pin 243a is aligned with the axial portion of the slot 243b ( Figure 17 ).

[0533] The carrier 221 including the container 225 can now be pushed into the housing 211 and in effect removed from the housing. Figure 17 Push in the starting position shown in Figure 18 in the final discharge position shown in .

[0534] As the carriage 221 moves into the housing 211 along the longitudinal axis 213, the seal 231 of the container 225 is ruptured by the tip 251 of the activation means 229 provided at the proximal end of the discharge device 215. As the carriage 221 continues its movement into the housing 211, the proximal portion 235 of the discharge device 215 enters the fluid space of the container 225, thereby forcing the fluid 227 out of the container 225. Since the proximal portion 235 sealingly fits into the distal cylindrical portion 221 b of the carriage 221, the fluid can only escape through the inlet passage 218 and, therefore, through the discharge passage of the tube 253 of the discharge device 215.

[0535] Thus, while the carriage 221 is still on its way into the final discharge position, fluid begins to flow through the inlet passage 218 and the inlet opening 217 and through the discharge passage to be ejected from the outlet opening 219 .

[0536] Since the proximal portion 235 of the discharge device 215 is also sealingly fitted into the fluid space of the container 225, leakage of fluid past the discharge device 215 is prohibited at any time.

[0537] Typically, the discharger and / or container can be made of any suitable material. In one embodiment, the material is plastic. The material can be selected from the group consisting of PP, COC, PE, PA, PBT, and PMMA. Alternatively, the material can be glass, metal, or an alloy.

[0538] From the above description, the skilled person will readily appreciate that the discharge system as described herein ensures simple and reliable one-handed operation for discharging a predetermined amount of fluid (such as a liquid containing at least one pharmaceutical, dental, or veterinary agent). Furthermore, the discharge system allows for long-term storage, as the use of a separate fluid container eliminates the need to store the fluid within the discharger itself. Instead, the fluid can be stored for an extended period of time within the container, which can be sealed by a rupturable seal in a manner that allows the fluid to be well protected from environmental influences.

[0539] With regard to a common classification for applications in the medical, dental or veterinary fields or in the healthcare industry, drains and drain systems as provided by the present disclosure belong to the group consisting of systems without protective caps.

[0540] Figure 22 A schematic representation of a first embodiment of a syringe 301 according to the present invention is shown in a storage position. The syringe 301 comprises a hollow body 302, a piston 303, and an intermediate piece 304. The hollow body has a surrounding hollow body surface 321 and a passage 322 therein. The hollow body 321 has a circular base surface and forms a cylindrical passage 322. Axis A is formed along the axial longitudinal direction of the hollow body 302. Furthermore, the passage 322 has a rear body opening 323 and a front body opening 324, which are arranged opposite each other in the longitudinal direction.

[0541] A first tubular hub 325 is formed at the front body opening 324 such that the front body opening 324 is closed except for the hub opening in the first hub 325. A needle cannula 326 is disposed in the first hub 325 and is movable along axis A relative to the first hub 325.

[0542] The piston 303 is arranged in the hollow body 302 and is movable in the passage 322 along the axis A. The piston 303 further comprises a front piston opening 331 arranged in the direction of the front body opening 324, and a rear closed piston end 332. The front piston opening 331 and the rear piston end 332 are arranged opposite each other along the axis A in the longitudinal direction.

[0543] An enclosing intermediate wall 333 is arranged between the front piston opening 331 and the rear piston end 332, forming a receiving chamber 334 for receiving a fluid. The receiving chamber 334 is divided into a first chamber 336 and a second chamber 337 by means of a separating element 335. The separating element 335 is formed as a membrane. Each of the chambers 336 and 337 can receive a fluid, with the first fluid being disposed in the first chamber 336 and the second fluid being disposed in the second chamber 337. In the storage position, the membrane separates the second chamber 337 from the first chamber 336 and, therefore, from the supply space 342 formed in the intermediate piece 304, preventing any flow connection between the two chambers.

[0544] In this regard, the first fluid may be, for example, a medicament to be dispensed, and the second fluid may be a flushing solution.

[0545] The middle piece 304 is movably arranged in the passage 322 along the axis A. A second needle hub 341 is formed in the middle piece 304, wherein the needle cannula 326 is securely held in the second needle hub 341. The middle piece 304 is in two parts and includes an outer element 345 and an inner element 344, wherein the second needle hub 341 is formed at the inner element 344. The inner element 344 further includes a support 346 for the outer element 345, which is formed as a peripheral shoulder. The support 346 is arranged in the direction of the front body opening 324 and acts as a stop for the outer element 345, thereby preventing the outer element 345 from moving. In addition, the inner element 344 is formed as a mandrel 348 in the direction of the rear body opening 323 to break the separation element 335. In addition, the middle piece 304 has a supply space 342, which is formed in the middle piece 304 and can particularly have a conical design. The second needle hub 341 and the supply space 342 are in flow communication, such that the first fluid and the second fluid can flow into the needle cannula 326 via the supply space 342 when the seal active in the storage position is deactivated.

[0546] The piston 303, the hollow body 302, and the intermediate piece 304 can be moved into the release position by means of a coaxial relative movement starting from the stored position. In the stored position shown in FIG. 301 (not shown), a first sealing area 343 is formed between the intermediate wall 333 and the outer element 345 of the intermediate piece 304, and a second sealing area, forming additional seals 347, 347a, is formed between the inner element 344 and the outer element 345. As viewed in the axial direction, the seal 347 is arranged in front of the supply space 342, and the seal 347a is arranged behind the supply space 342. The first sealing area 343 comprises a groove in the intermediate wall 333 of the receiving chamber 334 and a recess in the intermediate piece 304 or in the outer element 345. The second sealing areas 347, 347a each comprise an additional groove in the outer element 345 and a recess in the inner element 344.

[0547] The first sealing area 343 prevents the fluid from flowing out of the receiving chamber 334 and into the passage 322 of the hollow body 302. The second sealing area, on the one hand, prevents the fluid from flowing into the supply space 342 by means of the seal 347 in the storage position, and on the other hand, prevents the fluid from flowing between the inner element 344 and the outer element 345 and into the passage 322 of the hollow body 302 by means of the seal 347a. Therefore, the receiving chamber 334 and the supply space 342 are not in fluid communication in the storage position. Therefore, neither the first fluid nor the second fluid flows from the receiving chamber 334 into the supply space 342.

[0548] The receiving chamber 334 is delimited at the rear end by an inclined surface 355 which cooperates with the rear end of the intermediate piece 304 and will be described in conjunction with the following. Figure 24 and Figure 25 Let's look at this inclined surface in more detail.

[0549] Figure 23 1 shows a schematic representation of the first embodiment in the release position. The release position corresponds to the activated position, i.e. the piston 303 has been moved in the passage 322 along the axis A in the direction of the front body opening 324 by means of coaxial movement by means of force transmission (e.g. by pressing onto the rear piston end 332). In this respect, retaining means 27 are provided in the form of peripheral, inwardly projecting ribs, which retain the piston 303 at the hollow body surface 321 due to the generation of friction forces that must be overcome by means of force transmission.

[0550] In the release position, the inner element 344 has been moved along axis A in the direction of the front body opening 324 and is positioned on the first needle seat 325. In this respect, the inner element 344 is located on the first needle seat 325, and the first needle seat 325 and the second needle seat 341 together form a substantially continuous needle seat. In this respect, the needle cannula 326, which in the storage position is completely positioned within the first needle seat 325 and the second needle seat 341 and within the hollow body 302, has been moved along axis A through the front body opening 324 out of the hollow body 302 and is partially positioned outside the hollow body 302. The outer element 345 has also been moved along axis A in the direction of the front body opening 324 and is positioned on the abutment 346, thereby deactivating the sealing effect of the seal 347 of the second sealing area. As a result, in the release position, the first chamber 336 of the receiving chamber 334 and the supply space 342 are in fluid communication.

[0551] In the released position, the first fluid may flow from the first chamber 336 through the supply space 342 into the inner element 344 or into the hub opening formed therein, and may then flow into the needle cannula 326 .

[0552] During the subsequent transition to the flush position (not shown) after emptying the first chamber 336, the spindle 348 pierces the membrane, whereupon the second chamber 337 and the supply space 342 are in flow communication, and a flushing procedure can be performed by discharging the second fluid (i.e., by emptying the second chamber 337 through the needle cannula 326).

[0553] Figure 24 3. A schematic representation of the first embodiment after the discharge of the first and second fluids is shown. In this end position, the piston 303 contacts the intermediate piece 304, wherein the ramp 355 is formed at the rear end of the receiving chamber 334, while the pierced membrane 335 is inserted. The piston 303 is arranged almost completely in the passage 322 of the hollow body 302, wherein further movement of the piston 303 along the axis A in the direction of the front body opening 324 is prevented. The separating element 335 has been broken open by means of the spindle 348, and the second fluid has been discharged from the second chamber 337 ( Figure 23 ) flows into the needle cannula 326 via the supply space 342. Towards the rear beyond the ramp 355 in the axial direction, a recess into which the spindle 348 protrudes is provided.

[0554] The ramp 355 attempts to position the intermediate piece 304 together with the inner element 344 and the needle cannula 326 in a tilted position, however, this is not possible according to Figure 24 326 is not possible since the needle cannula 326 is still located in the first needle hub 325 and therefore cannot deflect or pivot.

[0555] Figure 25A schematic representation of the first embodiment is shown in a retracted position. In this retracted position, the piston 303 has been almost completely withdrawn from the passage 322 of the hollow body 302, with the front piston opening 331 disposed in the passage 322. The needle cannula 326 is securely held in the intermediate piece 304 via the inner element 344 at the second needle seat 341, so that when the piston 303 moves backward, the needle cannula 326 is pulled along with it. In this manner, the needle cannula 326 is completely drawn into the passage 322 and out of the first needle seat 325, thereby being released. This release of the needle cannula 326 allows the intermediate piece 304 (which is pre-biased into a corresponding tilted position due to the ramp 355) to assume an inclined position and, thus, position the needle cannula 326 in a skewed position, preventing it from accidentally or randomly reentering the first needle seat 325 and, thus, being trapped in the hollow body 302. Therefore, the needle cannula 326 or the syringe 301 cannot be reused without risk of injury.

[0556] Figure 26 A schematic representation of a second embodiment of a syringe according to the invention is shown in a storage position. In this respect, the design of the syringe 301 is similar to that of the syringe 301 from Figures 22 to 25 The syringes 301 have several common features so that the differences will generally be focused on.

[0557] Similar to Figures 22 to 25 The intermediate piece 304 is movably arranged in the passage 322 along the axis A. A second needle seat 341 is formed in the intermediate piece 304, wherein the needle cannula 326 is securely held in the second needle seat 341. Figures 22 to 25 Unlike the embodiment of the present invention, the middle piece 304 is in one part. The single-part middle piece 304 has a supply space 342 formed in the middle piece 304. Figure 26 In the storage position shown in FIG, a first sealing area 343a is formed between the intermediate wall 333 and the intermediate member 304, forming a first seal at the rear side of the supply space 342. A second sealing member 343b is arranged at the front side of the supply space 342. The seal formed by the first sealing area 343a includes a groove located in the intermediate wall 333 of the receiving chamber 334 and a recess located in the intermediate member 304. The first sealing area 343a prevents fluid from flowing into the supply space 342 in the storage position, while the second sealing member 343b prevents fluid from flowing from the supply space 342 into the passageway 322 of the hollow body 302. Therefore, the receiving chamber 334 and the supply space 342 are not in fluid communication in the storage position; that is, neither the first fluid nor the second fluid flows from the receiving chamber 334 into the supply space 342.

[0558] In the storage position, the piston 303 is held by the retaining device 27 and can only be moved by force transmission. In the active position (not shown), the piston 303 is held by the activation device 28 and can only be moved into the release position by force transmission. The needle cannula 326 is moved out in the active position. The separating element 335, which is only schematically shown here, is broken open in this second embodiment by means of a sharp peripheral edge 349 of the intermediate piece 304. Figures 22 to 25 The ramp may be provided in an alternative embodiment, or another device may be provided to pivot or deflect the needle cannula 326.

[0559] Figure 27 A schematic representation of a third embodiment of a syringe according to the invention is shown in a storage position. In this respect, the design of the syringe 301 is similar to that of the syringe from Figures 22 to 25 The syringes 301 have several common features, so that the differences will be primarily focused on. The two-part intermediate piece 304 is movably arranged in the passage 322 along the axis A. A second needle seat 341 is formed in the intermediate piece 304, wherein the needle cannula 326 is securely held in the second needle seat 341. A sharp peripheral edge 349 for breaking the separating element 335 is formed on the outer piece 345 in the direction of the rear piston end 332. The edge 349 does not have a peripherally constant height, but defines a plane 355 which is inclined relative to the axis A and similar to the Figures 22 to 25 In the embodiment of FIG. 3 , the inclined surface 355 ensures a skewed position of the needle cannula 326 in the retracted position.

[0560] Figure 28 A schematic representation of a fourth embodiment of a syringe according to the invention is shown in a storage position. The design of the syringe 301 corresponds substantially to that of Figures 22 to 25 The syringe 301 of FIG. 3 will be described below, so that the differences will be primarily focused on. The intermediate piece 304 is constructed in two parts, with the inner element 344 being configured such that the second needle hub 341 is hollow and cylindrical and has two different outer diameters, thereby forming a seat 346 for the outer element 345. Furthermore, the inner element 344 is formed as a further hollow body 305 in which the piston 303 is arranged. The inner element 344, constructed entirely in one piece, thus comprises the needle hub 341, which is arranged radially inward, and an outer part defining the hollow body 305, which is arranged concentrically with the needle hub 341 and receives the piston 303. The inner element 344 does not have a spindle 348.

[0561] The further hollow body 305 is arranged in the passage 322 of the hollow body 302. Thus, the coaxial relative movement of the piston 303 takes place along the axis A in the further hollow body 305 of the inner element 344, which in turn moves along the axis A in the hollow body 302.

[0562] The separating element 335 is designed as a plug and is arranged in the receiving chamber 334 so as to be movable along the axis A. The separating element 335 can be displaced by means of the outer element 345 of the intermediate piece 304 in order to empty the second chamber 337. Alternatively, it can be provided that the separating element 335, which is formed as a membrane, for example, is broken open by means of the outer element 345, in particular by means of a sharp edge formed on the outer element 345.

[0563] Furthermore, a sealing area 351, which is active in the storage position or the release position, is constructed and arranged between the intermediate wall 333 and the separating element 335 so that there is no flow connection between the second chamber 337 and the supply space 342, just as there is no flow connection between the second chamber 337 and the first chamber 336. The sealing area 351 comprises a groove in the intermediate wall 333 and a complementary recess in the separating element 335. In the flush position, the sealing area 351 is deactivated, and the second chamber 337 and the supply space 342 are in flow connection.

[0564] Figure 29 A schematic representation of a fifth embodiment of a syringe 301 according to the invention is shown in a storage position. The design of the syringe 301 corresponds substantially to that of Figures 22 to 25 The differences in syringe 301 will be primarily addressed. To ensure that needle cannula 326 is fully retracted into passageway 322 during the transition to the retracted position, a spring 352 is disposed within passageway 322. To overcome the restoring force of this spring, piston 303 must be pressed forward from the stored position. Thus, spring 352 facilitates or assists the transition to the retracted position, depending on the correct use of syringe 301.

[0565] Figure 30 An ejector 410 is shown including an ejector defining a longitudinal axis A. L The discharge section 412, the middle section 424 and the container 450 are provided. The discharge section 412 has a proximal end 414 and a distal end 416 and is provided with a wing-shaped protrusion 444, which is approximately located in the middle between the proximal end 414 and the distal end 416. The protrusion 444 is in the shape of a finger-like flange and is formed integrally with the discharge section 412, for example, by injection molding. The discharge section 412 includes a distal portion 446 at its distal end 416 that defines the outlet opening 422. The distal portion 446 can be, for example, a separate part fixed (for example, welded) to the discharge section 412, or it can be formed integrally with the discharge section 412, for example, by injection molding. In this embodiment, the distal portion 446 is designed as a spray head, preferably for large-area applications. However, the distal portion 446 can adapt to the type and location of the application and can also include a needle (cannula), a brush, a sponge, a pipette, etc.

[0566] The intermediate section 424 includes a proximal portion 428 and a distal portion 426, which are formed as one piece and interconnected by a rupturable section 432. The rupturable section 432 is located at the distal end 429 of the proximal portion 428 and has the shape of a tearable membrane or web. The rupturable section 432 is made of the same material as the proximal portion 428 and the distal portion 426.

[0567] The distal portion 426 of the intermediate section 424 has a receiving end 448 with an opening 449 for receiving the proximal end 414 of the discharge section 412. The proximal end 414 is simply inserted into the distal portion 426 without further securing the connection by welding or gluing.

[0568] The proximal portion 428 of the intermediate section 424 also has a receiving end 438 with an insertion opening 440 and defines a receiving space 430 adapted to be loaded with a separate container 450. The container has a proximal end 457 and is inserted into the receiving space 430 by sliding the container 450 through the insertion opening 440.

[0569] Generally speaking, the discharger 410 is composed of three separate parts, namely the discharge section 412, the middle section 424 and the container 450. Generally speaking, the distal section 446 can also be an additional separate part.

[0570] The distal portion 426 of the intermediate section 424 includes a sealing lip 425 disposed circumferentially around the distal portion 426. The sealing lip 425 is defined by a circumferential region of the distal portion 426 that has a larger diameter than the remainder of the distal portion 426.

[0571] Figure 31 A cross-sectional view of the discharger 410 is shown wherein the distal end 416 and the distal portion 446 of the discharge section 412 have been omitted for purposes of improved visualization.

[0572] Figure 31 It is revealed that the distal portion 426 of the intermediate section 424 further comprises an activation means 434 enclosed by the proximal portion 428 of the intermediate section 424. The activation means 434 is in the shape of a piercing tip having a dome-shaped profile 435 that is substantially complementary to the inner wall portion 456 of the container 450. The activation means 434 further comprises a flow channel 436 that provides a flow connection to the inlet opening 420 of the discharge passage 418, which is arranged along the longitudinal axis A. L The flow channel 436 extends centrally within the discharge section 412. The flow channel 436 is centrally located within the dome-shaped activation device 434 and further includes two separate deformable ridges 437 positioned adjacent to the inlet opening of the flow channel 436. The flow channel 436 extends along the longitudinal axis A. Lextend.

[0573] also, Figure 31 The container 450 is disclosed as comprising a fluid reservoir 451 containing a quantity of fluid 452 to be discharged. The container 450 further comprises a distal face 458 formed by a rupturable seal 454. An inner wall portion 456 of an inner wall 459 of the container 450 is rotationally symmetrical and approximately complementary to the dome-shaped profile 435 of the activation device 434.

[0574] Furthermore, it can be seen that the receiving space 430 is defined by the area between the receiving end 438 and the transition portion 442, which serves as a stop for the container 450 when it is loaded into the receiving space 430. Only roughly one-seventh of the total length of the container 450 is received in the receiving space 430. The remainder of the container 450 protrudes from the receiving end 438 of the proximal portion 428.

[0575] Figure 32 The discharger 410 is shown with the proximal portion 428 in its final discharge position, ie, the proximal portion 428 has been moved toward the distal end 416 of the discharge section 412 (see FIG. Figure 30 ) is fully moved into position. In this position, the rupturable section 432 (see Figure 1 and Figure 2 ) is ruptured and the distal portion 426 of the intermediate section 424 is located in the fluid reservoir 451 of the container 450. The seal 454 has been pierced and the fluid 452 has been expelled through the activation device 434. The deformable ridge 437 (see Figure 31 ) has been compressed so that the activation device 434 and the inner wall portion 456 of the container 450 establish a form-fitting connection.

[0576] It can further be seen that the sealing lip 425 of the distal portion 426 fits tightly against the inner wall 459 of the container 450, thereby preventing fluid from leaking out of the container 450 beyond the receiving end 448 of the distal portion 426. The complementary shapes of the inner wall portion 456 of the container 450 and the profile 435 of the activation device 434 ensure that there is virtually no residual amount of fluid 452 within the container 450.

[0577] To operate the ejector 410 (ie, to eject the fluid 452 inside the container 450 from the outlet opening 422 through the ejection passage 418 ), the proximal portion 428 is pushed toward the distal end 416 with the container 450 protruding from the receiving end 438 .

[0578] When the proximal portion 428 is in the Figure 1 and Figure 2, the rupturable section 432 is still intact and the activation device 434 is still positioned spaced apart from the seal 454 of the container 450. In other words, the activation device 434 has not yet protruded into the fluid reservoir 451 of the container 450.

[0579] When an axial force is applied to the proximal portion 428 of the intermediate section 424 by actuating the button-like proximal end 457 of the container 450 (the user can push the proximal end with his thumb while counteracting the actuation by holding the protrusion 444 with two fingers behind the protrusion 444), in a first step, the rupturable section 432 ruptures and the proximal portion 428 is transferred to its starting position. In the starting position, the proximal portion 428 is positioned along the longitudinal axis A. L The container 450 is movable relative to the distal portion 426 toward the distal end 416 of the discharge section 412. In a second step, in order to discharge the fluid 452, the user must intentionally push the container 450 toward the distal end 416.

[0580] Generally speaking, the movement of the proximal portion 428 between the initial position and the starting position and further toward the final discharge position may preferably be adapted to be a flowing movement such that the fluid may be discharged uniformly.

[0581] As the proximal portion 428 moves toward the distal end 416 along with the container 450, the deformable ridge 437 initially pierces the seal 454, while the dome-shaped activation member 434 then pierces the seal 454. The activation member 434 enters the fluid reservoir 451 of the container 450, thereby forcing fluid 452 out of the container 450 through the flow channel 436 connected to the exhaust passage 418. Due to the complementary shapes of the activation member 434 and the inner wall portion 456 of the container 450, the fluid 452 can only escape through the flow channel 436. Since the distal portion 426 is sealingly fitted into the fluid reservoir 451 by means of the sealing lip 425, leakage of the fluid past the distal portion 426 is prohibited at all times.

[0582] In general, the discharger 410 can be made of any suitable material. Preferably, the material can be plastic. The material can be selected from the group consisting of polypropylene, cycloolefin polymer, polyethylene, polyamide, polybutylene terephthalate, and polymethyl methacrylate. Alternatively, the material can be glass, metal, or an alloy.

[0583] It is particularly preferred that the discharger 410 (ie each of the container 450 , the intermediate section 424 and the discharge section 412 ) can be manufactured as an injection-molded part by injection molding.

[0584] With regard to a common classification for applications in the medical, dental or veterinary fields or in the healthcare industry, the emitter as provided by the present disclosure belongs to the group consisting of systems without a protruding cap.

[0585] according to Figure 33 The dispensing device 501 comprises a dual syringe 502 and a mixing and spraying head 503 attachable thereto. In a known manner, the dual syringe comprises two storage containers 504 and 505, each having equal volume or equal cross-sectional area or a cross-sectional area ratio different from 1:1. The two components are dispensed by means of a dual plunger 506.

[0586] The mixing and spraying head 503 (hereinafter referred to as the "head" for simplicity) basically consists of three parts, namely the transfer housing 507 and the mixing and spraying part 4508, which can be connected to the transfer housing by snap-fit ​​devices, welding, gluing, screw connection or by means of bayonet connection.

[0587] Basically, the head can be connected to the dispensing device in different ways, for example by means of a bayonet coupling or by means of a screw connection. Advantageously, however, the head can simply be inserted into the dispensing device and can be easily removed therefrom by means of a connection, as described in Swiss patent application No. 00453 / 06 in the name of the applicant of the present invention. To this end, the fastening area 509 on the outlet side of the dispensing device has an outlet flange 510 on which two separate outlets 511 and 512 are arranged. Each outlet 511 and 512 has a ridge 513 or 514, which is arranged essentially along the diameter and points outwards and which tapers gradually from the outlet flange 510 towards the outlet. Each ridge has a saddle-shaped portion 515 or 516 which ends at a certain distance from the outlet flange and is followed by a snap-on nose 517 or 518 which engages in recesses 519 and 520 in the transfer housing 7 (see Figure 36 ).

[0588] The two saddles 515, 516 have the same configuration, but saddle 515 has an end portion 521 on the outlet side, while saddle 516 does not. The presence or absence of end portion 521 constitutes a coding device, ensuring that the head can only be attached in a specific orientation. In addition, both outlets are provided with clamping guides 522 on both sides of their connection plane. In addition, the outlet flange 510 has a visual coding nose 523, which serves as an orientation aid for the head, which has a corresponding orientation nose 524.

[0589] exist Figure 34, a two-part head 503 is shown, wherein the mixing and spraying element 508 is fastened to a transfer housing 507, the end of which forms the rear chamber bottom wall 544 of the mixing and vortex chamber. The transfer housing 507 has a distributor socket 525 at its outlet-side end, in which four distributor outlets 526 and two positioning grooves 527 are arranged. In the corrugated area 528, the housing is compressible to disengage the snap-on noses 517 and 518 from the recesses 519 and 520, thereby allowing the head to be withdrawn.

[0590] As according to Figure 36 It turns out that two longitudinal holes 529 and 530 are arranged in the dispenser socket, which communicate with transverse holes 530 and 532, which lead to the dispenser outlet 526. The coding and orientation nose allows the head to be plugged onto the dispenser in such a way that the longitudinal holes 529 and 530 coincide with the outlets 511 and 512 of the dispenser.

[0591] As appears in Figure 354, a longitudinal feed passage 533 extends from the end 526 of the transverse hole. Figure 36 , the coupling portion 534 of the mixing and spraying element 4508 is shown to have a circumferential groove 535 for receiving a corresponding collar 535A on the transfer housing. The housing portion 534 further includes two positioning cams 536 that engage in corresponding positioning grooves 527. The closing element 537 of the mixing and spraying element 508 has four longitudinal channels 538 leading to an annular mixing chamber 539, from which four feed passages 540 lead to a concentric vortex chamber 541, from which a spray outlet 542 leads to the exterior.

[0592] exist Figure 36A In FIG, a variant embodiment is shown in which the compressed air inlet 560 is arranged on the end plate 450 of the mixing and spraying member 561 in order to achieve a better spraying action in certain circumstances. The rest of the head is the same.

[0593] exist Figure 38 What can be seen in Figure 5 is that feed passage 540 and feed conduit 543 do not form the same angle with respect to mixing chamber but are offset from each other.In addition, feed passage, feed conduit, and vortex chamber and mixing chamber need not be arranged in the same plane with respect to the longitudinal axis of head respectively.

[0594] exist Figure 39 It is evident that the bottom wall 544 of the mixing chamber is plane, while at the top (i.e. in the closure 537) there are arranged sawtooth mixing elements 45 which create turbulence in order to mix the two components before they reach the vortex chamber from which they are sprayed through the spray outlet.

[0595] As mentioned in the introduction, the present invention essentially aims at providing a mixing assembly in front of the spraying assembly, more particularly in front of the vortex chamber, in order to achieve an efficient mixing of the components before the actual spraying process. Instead of providing an annular concentric mixing chamber with sawtooth-shaped mixing elements, according to Figures 40 to 42 It is also possible to provide a mixing assembly comprising static mixing elements known per se. Figure 40 The dispensing device 546 includes the same dispensing device 502 and the same fastening area as in the previous example. The fastening area of ​​the transfer housing 547 is the same as in the previous exemplary embodiment, while the mixer socket 548 is configured to receive the mixing assembly 549 in its interior and the fastening means 450, 551 on its exterior in order to attach the mixing and spraying member 558 to the transfer housing 5547, thereby forming a mixing and spraying head 555.

[0596] The mixing assembly 549 with the mixing element 552 is fastened inside the closure 553 of the mixing and spraying element 558 and forms a unit with the latter. The fastening means 550, 551 for attaching the mixing and spraying element to the transfer housing 547 can be snap-fit, bayonet or screw connections, or it can be fastened by ultrasonic welding or gluing.

[0597] As according to Figure 42 It turns out that the closure 553 of the head has feed passages 554 arranged therein, for example three feed passages, which in the same way as in the previous examples lead to a swirl chamber 556 from which a spray outlet 557 leads to the outside.

[0598] Based on the two exemplary embodiments of the mixing chamber or mixing assembly, respectively, a person skilled in the art can design other possibilities for mixing assemblies, according to which the components (the number of which may also be greater than two) are efficiently mixed just before entering the vortex chamber before being sprayed through the vortex chamber and the spray outlet.

[0599] Figures 43 to 55 A corresponding applicator 1100 for nasal decolonization using a fluid F is shown. The applicator 1100 comprises an application tip 1019 adapted to be inserted into the nasal cavity. The application tip 1019 is configured to store and release the fluid F. The applicator 1100 further comprises a support 1101 to which the application tip 1019 is connected or at which it is integrally formed.

[0600] The application tip 1019 is formed from at least one of: open cell foam, plastic, flocked fibers (which may have a diffused polymer such as polyester), cotton, polyester, rayon, calcium alginate, foam, knitted polyester, medical grade plastic, thermoplastic elastomer, low density polyethylene (LDPE), acrylonitrile butadiene styrene (ABS), polypropylene (PP), polyethylene (PE), high density polyethylene (HDPE), polycarbonate (PC), polyurethane (PU), polyetheretherketone (PEEK) and polyvinyl alcohol (PVA).

[0601] The end 1102 of the application tip 1019 at least partially has at least one of the following shapes: a conical outer shape, an at least substantially conical outer shape, a truncated cone shape, an at least substantially truncated cone shape, a circular shape, an at least substantially circular shape, a spherical shape, an at least substantially spherical shape, an oval shape, an at least substantially oval shape, a rounded edge and a combination of the foregoing, i.e., a shape that increases in size between the end 1102 and the middle part of the application tip 1019.

[0602] Figures 43 to 48 The discharge system is shown as an applicator 1100 comprising a dispenser 1010 into which a separate container 1025 having a generally cylindrical outer shape can be loaded.

[0603] Although other applications are possible, in the embodiment shown, the dispenser 1010 is intended for use in the medical, dental or veterinary fields and is used, in practice, to discharge a predetermined amount of fluid 1027 ( Figure 46 ). The fluid to be discharged is a liquid comprising one or more medical, dental or veterinary agents.

[0604] The dispenser and container are designed as disposable items intended for single use only.

[0605] The container 1025 is formed as a capsule having a generally cylindrical outer shape. The container 1025 includes a wall portion 1041 ( Figure 47 ), the wall portion having an integral proximal portion providing a proximal face and an opening at the distal end, the opening being closed by a rupturable seal 1031 in the form of a foil. The wall portion 1041 and the seal 1031 define a fluid space of the container, which is at least partially filled with a fluid 1027. The amount of fluid is, for example, 0.e5 ml or 2 ml.

[0606] In such Figure 43 In the ready-to-use state shown in FIG, the container 1025 has been loaded into the tray 1021 of the dispenser 1010. To be loaded into the tray 1025, the container 1025 is slid through the proximal insertion opening 1033 of the tray 1021.

[0607] The bracket 1021 is received in the proximal region of the housing 1011, 1011, which is provided with wing-shaped protrusions 1027 extending in opposite directions as in a conventional disposable syringe. In addition, a groove 1043b is formed in the housing 1011, 1011, which cooperates with a pin 1043a formed at the bracket 1021 to form a fixing means, which will be explained in more detail later.

[0608] The dispenser 1010 further comprises a discharge device 1015, Figures 42 to 10 45 shows a pipe 1053 from the discharge device ( Figure 46 ), the tube extends from the inside of the housing 1011, 1011 toward the thickened distal portion 1055 ( Figure 46 ) extends. The end portion 1055 may be integral with the tube 1053 or be made as a separate component connected to the tube 1053 in a suitable manner.

[0609] The dispenser 1010 is adapted to discharge the fluid 1027 inside the container 1025 through the discharge device 1015 simply by pushing the bracket 1021 containing the container 1025 into the housing 1011. This process is incorporated elsewhere Figures 46 to 48 Described.

[0610] The fixing means 1043a, 1043b prevent the bracket 1021 from being accidentally pushed into the housings 1011, 1011. Figure 43 In the initial condition shown in FIG, the pin 1043a of the bracket 1021 is located at the end of the circumferential portion of the slot 1043b ( Figure 44 This condition prohibits the bracket 1021 from moving along the longitudinal axis 1013 of the dispenser 1010 ( Figure 47 )move.

[0611] To discharge the fluid, the user must intentionally rotate the bracket 1021 relative to the housing 1011, 1011 to align the pin 1043a with the axial portion of the slot 1043b ( Figure 44 In order to facilitate the rotation of the bracket 1021 , a longitudinal groove 1022 is provided on the outer wall of the bracket 1021 .

[0612] exist Figure 44 , the bracket 1021 is in a starting position and is ready to be pushed into the housing 1011.

[0613] Figure 45 The tray 1021 is shown in a final discharge position, in which the tray 1021 and therefore the loaded container 1025 are completely received in the shell 1011, and the proximal surfaces of the tray 1021 and the container 1025 are flush with the proximal surface of the shell 1011.

[0614] from Figures 43 to 45 It can be seen that the tray 1021 and container 1025 together can be actuated like a button, with the user pressing the tray and container with his or her thumb while counteracting the push by gripping the housing with two fingers behind the protrusion 1047.

[0615] like Figure 46 As shown in FIG, the discharge device 1015 includes a sleeve portion 1057 formed integrally with the housings 1011, 1011 and arranged inside the housing 1011. Further, the discharge device 1015 includes the above-mentioned pipe 1053 fitted into the sleeve portion 1057.

[0616] The proximal portion 1035 of the discharge device 1015 ( Figure 47 ) is assembled into the distal cylindrical portion 1021b of the bracket through the distal opening 1037 of the bracket 1021. The proximal portion 1035 includes an inlet opening 1017 at the proximal end of the tube 1053, an inlet passage 1018 formed at the proximal end of the sleeve portion 1057, and a tip 1051 ( Figure 47 ) activation device 1029 ( Figure 46 ), the tip being formed by a corresponding tapering of the proximal end of the cannula portion 1057. Figure 46 In the initial condition shown in the figure, the tip 1051 is still positioned to be spaced apart from the seal 1031 of the container 1025, that is, the activation device 1029 including the tip 1051 has not yet protruded into the proximal cylindrical portion 1021a of the bracket 1021, which defines the receiving space 1023 of the bracket 1021 for the container 1025.

[0617] An axial portion of the inlet passage 1018 extends offset from the longitudinal axis 1013 and opens into a radial portion of the inlet passage 1018 that opens into the inlet opening 1017 of the tube 1053 .

[0618] A discharge passage extending through the tube 1053 connects the inlet opening 1017 with an application tip 1019 ( Figure 46 )connect.

[0619] As especially in Figure 46 and Figure 48 As can be seen in FIG, the housings 1011, 1011 generally have a cylindrical outer shape with a constant inner diameter that is equal to the outer diameter of the proximal cylindrical portion 1021a of the bracket 1021. In order to also conform the distal cylindrical portion 1021b (which has an outer diameter smaller than that of the proximal cylindrical portion 1021a) to the inner diameter of the housing 1011, a flange 1049 is formed integrally with the distal cylindrical portion 1021b.

[0620] Furthermore, the thickness of the wall portion 1041 of the container 1025 corresponds to the difference between the inner diameters of the cylindrical portions 1021a, 1021b of the cradle 1021. Therefore, the container 1025 reduces the inner diameter of the proximal cylindrical portion 1021a to the inner diameter of the distal cylindrical portion 1021b, thereby establishing an inner space of the cradle 1021 having a constant inner diameter that corresponds to the outer diameter of the proximal end portion 1035 of the discharge device 1015.

[0621] This dimensioning of the various components of the discharge system provides for mechanically reliable mutual guidance of the various components when the carrier 1021, including the container 1025, is inserted into the housing. Specifically, the carrier 1021 is guided through its flange 1049 and its proximal cylindrical portion 1021a by the inner wall of the housings 1011, 1011. In addition, the carrier 1021 is guided by the discharge device 1015.

[0622] Furthermore, the design of the various components as explained above minimizes the required outer dimensions of the dispenser 1010, in particular the outer diameter of the housing 1011. Figure 48 As can be seen in FIG, there is no unused space inside the housing 1011. When the rack 1021 including the container 1025 is in the final discharge position, all components are concentrically packed inside the housing 1011.

[0623] The transition portion 1021c of the carrier 1021 between the proximal cylindrical portion 1021a and the distal cylindrical portion 1021b is formed as a circumferential shoulder that serves as an axial stop for the container 1025 when the container is loaded into the carrier 1021. The axial distance between the proximal end surface of the proximal cylindrical portion 1021a and the transition portion 1021c corresponds to the axial length of the container 1025.

[0624] The outer shape of the tapered proximal end of the discharge device 1015 corresponds to the proximal section 1045 of the inner wall of the container 1025, so that when the bracket 1021 including the container 1025 is in its final post-discharge position, almost no free space is left inside the container 1025, as shown in FIG. Figure 48 Thus, the complementary shapes of the discharge device 1015 and the container 1025 ensure that almost no residual amount of fluid is left in the container 1025.

[0625] Since relevant regulations in many countries prohibit simply throwing away medical, dental or veterinary substances, the absence of large residual fluid quantities as provided by the discharge system as described herein simplifies the disposal of used containers and dispensers in accordance with the respective national regulations.

[0626] In operation, Figure 43 In the initial state shown in FIG, the fixing means 1043 a, 1043 b prevent the bracket 1021 from being accidentally pushed into the housing 1011.

[0627] In order to discharge the fluid contained in the container 1025 (which has been previously loaded into the bracket 1021), the user must rotate the bracket 1021 so that the pin 1043a is aligned with the axial portion of the slot 1043b ( Figure 44 ).

[0628] The carrier 1021 including the container 1025 can now be pushed into the housing 1011 and in effect removed from the housing. Figure 44 Push in the starting position shown in Figure 45 in the final discharge position shown in .

[0629] As the carriage 1021 moves into the housing 1011 along the longitudinal axis 1013, the seal 1031 of the container 1025 is ruptured by the tip 1051 of the activation means 1029 disposed at the proximal end of the discharge device 1015. As the carriage 1021 continues its movement into the housing 1011, the proximal portion 1035 of the discharge device 1015 enters the fluid space of the container 1025, thereby forcing the fluid 1027 out of the container 1025. Because the proximal portion 1035 sealingly fits into the distal cylindrical portion 1021 b of the carriage 1021, the fluid can only escape through the inlet passage 1018 and, therefore, through the discharge passage of the tube 1053 of the discharge device 1015.

[0630] Thus, while the carriage 1021 is still on its way into the final discharge position, fluid begins to flow through the inlet passage 1018 and the inlet opening 1017 and through the discharge passage for dispensing from the application tip 1019 .

[0631] Since the proximal portion 1035 of the discharge device 1015 is also sealingly fitted into the fluid space of the container 1025, leakage of fluid past the discharge device 1015 is prohibited at any time.

[0632] Typically, the dispenser and / or container can be made of any suitable material. In one embodiment, the material is plastic. The material can be selected from the group consisting of PP, COC, PE, PA, PBT, and PMMA. Alternatively, the material can be glass, metal, or alloy.

[0633] From the above description, the skilled person will readily appreciate that the discharge system as described herein ensures simple and reliable one-handed operation for discharging a predetermined amount of fluid (such as a liquid containing at least one pharmaceutical, dental, or veterinary agent). Furthermore, the discharge system allows for long-term storage, as the use of a separate fluid container eliminates the need to store the fluid within the dispenser itself. Instead, the fluid can be stored for a long period of time within the container, which can be sealed by a rupturable seal in a manner that allows the fluid to be well protected from environmental influences.

[0634] With regard to a common classification of applications in the medical, dental or veterinary fields or in the healthcare industry, dispensers and discharge systems as provided by the present disclosure belong to the group consisting of systems without protective caps.

[0635] The activation device 1029 of the dispenser 1010 may be positioned inside the housings 1011 , 1011 so as to protrude into the receiving space 1023 when the carriage 1021 moves from the starting position toward the final discharge position.

[0636] The activation means 1029 may be provided with means for rupturing the seal 1031 , in particular for piercing, penetrating, puncturing and / or perforating the seal 1031 .

[0637] The carrier 1021 may have a proximal end with an insertion opening 1033 through which the receiving space 1023 is accessible, and the carrier may be adapted to be loaded with a container 1025 by sliding the container through the insertion opening into the receiving space.

[0638] The discharge device 1015 is adapted to guide the carriage 1021 along the longitudinal axis as the carriage moves from the starting position towards the final discharge position.

[0639] The discharge device 1015 may have a proximal portion 1035 which is substantially facing the receiving space 1023 , an activation means 1029 , and an inlet opening 1017 formed at or integrated into the proximal region.

[0640] The discharge device 1015 may have a proximal portion 1035 including an inlet opening 1017, and wherein the bracket 1021 has a distal opening 1037, and the discharge device extends with its proximal portion through the distal opening into the bracket, in particular wherein the proximal portion 1035 of the discharge device 1015 may be sealingly assembled into the bracket 1021 so as to at least substantially prevent fluid from leaking through the distal opening 1037 of the bracket.

[0641] The outer diameter of the proximal portion 1035 of the discharge device 1015 may be smaller than the inner diameter of the bracket 1021 in the area of ​​the receiving space 1023 so as to provide a receiving space 1039 for the wall portion 1041 of the container 1025, which is arranged around the proximal portion of the discharge device when the bracket moves toward the final discharge position.

[0642] The bracket 1021 may generally have a multi-cylindrical shape, which includes at least a proximal cylindrical portion 1021a and a distal cylindrical portion 1021b, wherein the proximal cylindrical portion defines a receiving space 1023 for the container 1025, in particular, wherein the outer diameter of the proximal cylindrical portion 1021a of the bracket 1021 is greater than the outer diameter of the distal cylindrical portion 1021b of the bracket 1021.

[0643] The inner diameter of the proximal cylindrical portion 1021 a of the bracket 1021 may be greater than the inner diameter of the distal cylindrical portion 1021 b of the bracket 1021 .

[0644] Inside the bracket 1021 , a transition portion 1021 c may be provided between the proximal cylindrical portion 1021 a and the distal cylindrical portion 1021 b , the transition portion 1021 c defining a distal end of the receiving space 1023 and serving as a stopper for the container 1025 loaded into the receiving space.

[0645] The dispenser 1010 further includes fixing devices 1043, which are suitable for preventing the bracket 1021 from unintentionally moving along the longitudinal axis 1013 from the starting position, in particular, the fixing devices 1043 may include a pin / slot arrangement structure, which has at least one pin 1043a formed at the bracket 1021 and at least one slot 1043b formed in the wall 1011a of the shell 1011, the pin 1043a being guided by the slot 1043b, in particular, the slot 1043b may include a portion extending parallel to the longitudinal axis 1013 and a portion extending in a plane extending not parallel to the longitudinal axis 1013.

[0646] The dispenser can be used to discharge a liquid comprising at least one pharmaceutical, dental or veterinary agent, wherein, in particular, the amount of liquid lies in the range of 0.2 ml to 2 ml and preferably is approximately 0.5 ml.

[0647] Figure 49 and Figure 50 An applicator device 1120 is shown, which is for example used for dispensing free-flowing fluids and comprises a carrier body 1122 to which the application tip 1019 is connected. The application device 1120 has a discharge opening 1124 for supplying fluid to the application tip 1019.

[0648] On the side opposite the application tip 1019, the carrier body 1122 has a cylindrical, piston-like pin 1126, which is surrounded by an annular recess 1128, which in turn is bounded on the outside by a peripheral wall 1130. A collar 1132, which serves as a gripping aid, is in turn molded onto the peripheral wall 1130.

[0649] In the terminal region opposite the application tip 1019 , the pin 1126 is penetrated by a transverse channel 1134 extending in the radial direction. An axial channel 1144 located on the axis of the pin 1126 in turn branches off from the transverse channel 1134 and extends to the discharge opening 1124 of the application device 14 .

[0650] The applicator device 1120 further comprises a reservoir device 1136 in which a free-flowing substance can be stored. The reservoir device 1136 comprises a tubular guide section 1138 and a seat section 1140 adjacent to the side furthest away from the applicator device 1120. The seat section 1140 defines a seat chamber 1142 for the free-flowing substance. The guide section 1138 has an annular edge seal 1146 on its inner side, which is positioned so that it can slide on the peripheral surface of the cylindrical pin 1126. The seat section 1136 is embodied in the shape of a tube and has a sealing seam 1148 in its terminal region further away from the pin 1126. The reservoir device 1136 is made of an elastically deformable material so that the seat section 1140 can be manually compressed.

[0651] exist Figure 49 In the position of the reservoir device 1136 shown in FIG, the edge seal 1146 is located in the terminal region of the peripheral surface of the pin 1126 so that the flow of fluid between the receptacle chamber 1142 and the transverse channel 1134 is blocked. To activate the applicator device 1120, the reservoir device 1136 is moved to Figure 50 1134 . During this process, the edge seal 1146 passes through the transverse channel 1134, so that a flow connection is created between the receptacle chamber 1142 and the transverse channel 1134 via the annular gap between the cylindrical pin 1126 and the guide section 1138 of the reservoir device 1136. As a result of manual pressure applied to the side of the receptacle section 1140, the free-flowing substance contained in the receptacle chamber 1142 can be discharged from the receptacle chamber 1142 and transported via the transverse channel 1134 and the axial channel 1144 to the discharge opening 1124 of the application device 1120 and applied.

[0652] Figure 51 and Figure 52 An alternative implementation of an applicator assembly 1100 is shown that includes a reservoir assembly 1150 that replaces Figure 49 The reservoir device 1136 shown in FIG. 1 is that the reservoir device can be placed on the carrier body 1122.

[0653] The reservoir device 1150 comprises a tubular guide section 1138 having two annular edge seals 1146A and 1146B on the inside, which interact with the cylindrical pin 1126 of the carrier body 1122. At the end further away from the edge seals 1146A and 1146B, a bubble-shaped receptacle section 1152 adjoins the guide section 1138, which contains the fluid to be applied and is elastically compressible.

[0654] In the middle region of the guide section 1138 there is also a widened region 1154 which, in the activated position of the reservoir device 1150, is located on the cylindrical pin of the carrier body 12 at the level of its transverse channel 1134. Advantageously, the widened region 1154 improves the flow behavior of the fluid and acts as a stop during activation of the applicator device 10'. The function of the reservoir device 1150 and its interaction with the carrier body 1018 corresponds to Figure 49 and Figure 50 The implementation shown in .

[0655] The elastically deformable region of the receptacle section 1152 of the application device 1120 may be in the form of a bubble.

[0656] The elastically deformable region of the receptacle section 1152 of the application device 1120 may be in the form of a small tube.

[0657] The elastically deformable region of the receptacle section 1152 of the application device 1120 may be in the form of a collapsible tube.

[0658] The reservoir device of the applicator device 1120 may comprise a guide section having a widened area which, during activation of the applicator device, is located at the level of the transverse channel of the pin.

[0659] The reservoir device of the application device 1120 may comprise at least two receptacle bodies, one receptacle body for each component of the multi-component system.

[0660] The at least two receptacle bodies can be telescoped to produce a flow connection, whereby at least one of the receptacle bodies has an edge seal on its inner side which interacts with the peripheral surface of the other receptacle body.

[0661] The pin 1126 has at least one annular groove that interacts with the edge seal 1146 and defines a deactivated position and / or an activated position of the receptacle device.

[0662] Pin 1126 may be cylindrical.

[0663] The applicator device 1100 may include a carrier body 1122, which is provided with an application device 1120 and has a cylindrical pin 1126 at the end farther from the application device 20, which is penetrated by a transverse channel 26, and an axial channel 28 branches off from the transverse channel, which axial channel leads to the application device 1120, whereby a reservoir device 1036, 1150 can be shifted on the cylindrical pin 1126, and the reservoir device has an annular edge seal 1146 on its inner side which interacts with the cylindrical pin 1126 in a sealing manner, whereby the applicator device is activated by shifting the reservoir devices 1136, 1150 on the cylindrical pin 1126 toward the application device 1120 to open a flow connection between the reservoir devices 1036, 1150 and the transverse channel 1134. The reservoir devices 1036, 1150 have receptacle segments 1038, 1140, 1152 that are elastically deformable in at least multiple portions, so that when a flow connection exists between the transverse channel 1036 and the receptacle segments 1038, 1140, 1152 in the activated position of the applicator device, free-flowing material is discharged through the application device 1120 by manually compressing the elastically deformable areas of the receptacle segments 1138, 1140, 1152.

[0664] Figure 53 An applicator 1100 is shown having a syringe 1060 as a dispenser. The syringe 1060 includes a plunger 1062 and a barrel 1064 in which a fluid can be stored. The plunger 1062 has a piston 1066 at its end, which is located opposite the end into which the plunger 1062 can be inserted. When a force is applied to the plunger 1062 in the direction of the barrel 1064, the piston 1066 acts on the fluid during the dispensing of the fluid from the barrel 1064 via the applicator tip 1019.

[0665] In this example, the syringe has a needle hub 1068 via which a stem 1070 carrying the application tip 1019 can be connected to the syringe 1060. It should be noted that the stem 1070 can also be formed integrally with the barrel 1064.

[0666] Thus, the applicator 1100 may further include a dispenser 1010, 1060, 1120, wherein the support member 1101 is a rod including a passage 1003, and the passage 1003 is connected to the outlet of the dispenser 1010, 1060, 1120 for dispensing liquid from the container of the dispenser to the application tip 1019 so as to supply the fluid to the application tip 1019.

[0667] Figure 54Another type of applicator 1100 is shown. The applicator 1100 further comprises a container 1080, which is optionally filled with said fluid F, wherein the applicator tip 1019 is stored in the container 1080 and optionally in said fluid F before use.

[0668] The applicator 1100 includes a handle 1082, which is part of a closure 1084 for the container 1080. The closure 1084 is a screw closure, via which the handle 1082 can be releasably screwed to the container 1080. For this purpose, the handle 1082 includes internal threads that mate with external threads 1086 present at the neck 1088 of the container 1080. The application tip 1019 and the stem can be inserted into and removed from the container 1080. It should be noted that other types of closures, such as bayonet-type closures, etc., can also be used.

[0669] The handle 1082 is part of the support 1101. The handle 1082 may be formed integrally with the support 1101 or may be connected to the support after the respective parts are manufactured.

[0670] Figure 54 The applicator 1100 may also be referred to as a lip gloss-type applicator 1100 .

[0671] Figure 55 Another type of applicator 1100 is shown. The container 1080 comprises two parts, one of which has a fluid reservoir for the fluid F. The two parts of the container 1080 are an outer container 1092 and an inner container 1094 .

[0672] exist Figure 55 In use of the applicator 1100, the handle 1082 is moved in the direction of the container 1080. This causes the applicator tip 1019 to penetrate the wall 1096 of the inner container 1094 (which is directly adjacent to the wall 1098 of the outer container 1092) and the wall 1098 of the outer container 1092 to be pierced, so that the applicator tip 1019 can enter the fluid reservoir 1090 and be moistened with the fluid in the reservoir 1090.

[0673] Rather than having two separate walls 1096 , 1098 , only the inner container 1094 or the outer container 1092 may have a respective wall that is pierced by the application tip 1019 .

[0674] The support may include one or more seals 1100 that seal between an inner surface 1102 of the inner container 1094 and the support 1101 .

[0675] If the wall 1098 of the outer container 1092 is directly attached to the inner surface 1104 of the outer container 1092 or the container 1080, then the inner container 1092 does not need to be present. In this case, the application tip will be stored in the space between the wall 1098 and the open end 1106 of the container 1080.

[0676] The walls 1096 , 1098 act as a membrane 1108 that seals the fluid F in the fluid reservoir 1090 .

[0677] The length of the application tip 1019 shown in the foregoing can be selected in the range of 0.2 cm to 5 cm, preferably in the range of 0.4 cm to 3 cm, in particular in the range of 0.5 cm to 2 cm.

[0678] The maximum outer diameter of the application tip 1019 shown in the foregoing can be selected in the range of 0.2 cm to 3 cm, preferably in the range of 0.3 cm to 2 cm, in particular in the range of 0.5 cm to 1.5 cm.

[0679] The larger the size of the application tip 1019, the more suitable it can be used in the nasal cavity of, for example, a horse or a cow, and the smaller the size, the more suitable it can be used in a cat or a dog, while the medium range can be used in an adult.

[0680] When using the applicator 1100, its application tip 1019 is inserted into the nasal cavity of a patient (not shown). The moistened application tip 1019 is then held in place and the fluid F stored therein is released by moving (e.g., rotating and pushing) the application tip 1019 relative to the nasal cavity so as to coat the nasal cavity with the fluid F. Depending on the applicator 1100, the application tip 1019 already includes the fluid F and is inserted into the nasal cavity while moistened. If the application tip 1019 does not yet include the fluid F, when using an applicator 1100 in one of the examples with a dispenser, the application tip 1019 is then inserted into the nasal cavity, where it is then moistened with the fluid F using the dispenser, and the fluid F is thereafter distributed over the nasal wall.

[0681] Figure 56 Still another perspective view of another type of drain 1200 is shown. The drain 1200 is formed from at least two parts, an outer housing component 1202 and an inner housing component 1204.

[0682] The inner housing member 1204 has a base 1206 at one end 1208 thereof, via which the discharger 1200 can be grasped. The inner housing member 1204 further includes a pin 1210 at a second end 1212 thereof. The first end 1208 and the second end 1212 of the inner housing member 1204 are disposed opposite each other.

[0683] The outer shell member 1202 includes a gripping plate 1214 at a first end 1216 thereof. The outer shell member 1202 further includes an outlet opening 1218 at a second end 1220 thereof. The first end 1214 and the second end 1220 of the outer shell member 1202 are disposed opposite each other.

[0684] First end 1208 of inner housing component 1204 is similarly disposed opposite second end 1220 of outer housing component 1202 .

[0685] The outlet opening 1218 is arranged on the longitudinal axis A L The second end 1220 of the outer body member 1202 is configured to be inserted into the corresponding nostril of the patient. Thus, the outlet opening 1218 is configured to spray the material stored therein into the corresponding nostril.

[0686] The outlet opening 1218 may be formed integrally with the outer housing member 1202 or may be formed by an insert (not shown) that is insertable into the second end 1220 and connectable to a passageway 1230 (see FIG. Figure 57 ), for example via a snap-fit ​​connection or a press-fit connection.

[0687] The outer housing component 1202 further includes a guide passage 1222 in which the pin 1210 of the inner housing component 1204 is guided during dispensing of material stored in the discharger 1200 .

[0688] Guide passage 1222 includes not only a store 1246 , but also a first branch 1248 , a second branch 1250 , a third branch 1252 , a fourth branch 1254 , a receptacle 1256 , a fifth branch 1258 , and an end stop 1260 .

[0689] The outer shell components further include Figure 57 The piercing tip 1224 is shown in FIG. The piercing tip 1224 can be constructed in the same manner as the piercing tips previously discussed. Figure 57 Shown along the section line A:A through Figure 56 Schematic cross-sectional view of the discharger 1200.

[0690] Inner housing component 1204 includes a sealing lip 1222 configured to interact with an outer surface 1225 of piercing tip 1224 to prevent material stored in the ejector from passing past piercing tip 1224 .

[0691] The piercing tip 1224 includes an inlet 1228 connecting the passage 1230 to the outlet opening 1218. If the piercing tip 1224 is moved toward the reservoir 1236 in the manner previously described, the material stored in the reservoir 1236 is sprayed through the outlet opening 1218.

[0692] In this example, the reservoir 1236 is formed by a separate cartridge 1234, which can be constructed in the same manner as previously described. The cartridge 1234 is sealed in isolation via a membrane 1232 so that the material is securely stored therein.

[0693] Inner housing component 1204 may also include an integrally formed reservoir 1236, which is then sealed off via membrane 1232, rather than using a cartridge.

[0694] The inner housing part further comprises guide noses 1238, 1240 protruding from its outer surface 1239. The guide noses 1238, 1240 engage an inner surface 1242 of the outer housing part 1202 and ensure that the inner housing part 1204 is guided within the outer housing part 1204.

[0695] Furthermore, the pin 1210 is visible as it protrudes into the outer housing component 1202 and in particular into the guide passage 1222 .

[0696] The ejector 1200 may include a child resistant element (not shown). The child resistant element may be formed by a lug (also not shown) in the guide passage 1222. The lug may include a predetermined breaking point that tears open if a certain force is applied to the lug.

[0697] The lugs will then be configured to retain the pin 1210 in the storage portion 1246 of the guide passage 1222 of the drain 1200 .

[0698] Upon initial activation of the ejector 1200, the inner housing component 1204 is moved away from the outer housing component 1202 by applying a force sufficient to rupture the predetermined rupture point of the child-resistant element.

[0699] After this, the pin 1210 moves into the first branch 1248. The second branch 1250 limits the pin from moving too far axially. In order to move the inner housing part 1204 for dispensing purposes, the inner housing part 1204 must be rotated relative to the outer housing part by guiding the pin in the second branch 1250.

[0700] Inner housing component 1204 may be rotated until pin 1210 reaches third branch 1252 , after which rotation of inner housing component 1204 is not possible and the user may move inner housing component 1204 axially into outer housing component 1202 .

[0701] Thus, piercing tip 1224 pierces membrane 1232 and permits dispensing of material while inner housing component 1204 moves into outer housing component 1202 the length of third leg 1252 until pin 1210 reaches fourth leg 1254 .

[0702] Once pin 1210 reaches the end of third leg 1250 , inner housing component 1204 cannot move further axially into outer housing component 1202 and must be rotated relative to outer housing component by the length of fourth leg 1252 in order to move inner housing component 1204 further.

[0703] Fourth branch 1252 terminates in a fifth branch that includes, at its oppositely disposed end, a receptacle 1256 and an end stop 1260. Pin 1210 can move into the receptacle when pressure on inner housing component 1204 is released (e.g., if the dispenser is moved from one nostril to the other), and can then move toward end stop 1260 when pressure is reapplied.

[0704] During this movement from the third branch 1252 to the fifth branch 1258, the user can move the discharger 1200 from one nostril to the other in order to apply the material stored therein at the different nostrils.

[0705] Figure 58 A view of the second end 1220 of the outer member 1202 is shown. As shown, the outlet opening 1218 is made of plastic. Insert 1270 is formed. The plastic insert is connected to the outer shell portion by a fixed connection (such as, laser weld 1266) Item 1202.

[0706] Insert 1270 further includes a sealing surface 1262 that seals against an outer wall 1272 of passageway 1230. 1230 is either integrally formed with the outer housing component 1202 or can be formed separately therefrom as shown in this example.

[0707] As indicated in this example, passage 1230 may be formed in a metal insert 1268. The second end 1220 is journaled via a sealing surface and the first end 1216 of the outer housing component 1202 is journaled via another sealing surface. The outer sealing surface 1264 of the journal connection, such as Figure 59 As indicated in .

[0708] The outlet opening 1218 may also be integrally formed with the outer housing member 1202 .

[0709] In this regard, it should be noted that the metal insert 1268 may include the piercing tip 1224, or the piercing tip 1224 may be surrounded by a metal insert 1268. Injection molded around metal insert 1268.

[0710] Reference Signs List

[0711] 1 Ejector

[0712] 2 Distribution components

[0713] 3 Shell

[0714] 4 Containers

[0715] 5 Remote

[0716] 6 Proximal

[0717] 7 Exit

[0718] 8 Distal region

[0719] 9 Proximal region

[0720] 10 Static piston

[0721] 10'10 center section

[0722] 11 Wing-like protrusion

[0723] 12 compartments

[0724] 13 membrane

[0725] 13' includes the plane of 13

[0726] 13” seal

[0727] 13" front end

[0728] 14 outer wall

[0729] End of 14'14

[0730] 14”14 outer surface

[0731] 15 resection port

[0732] 16 slots

[0733] 17, 17' longitudinal section

[0734] 18 Connecting sections

[0735] 19, 19' pin

[0736] 20 Luer lock

[0737] 21 end

[0738] 22 recess

[0739] 23 Entrance

[0740] 23' away from the end of the entrance

[0741] 24, puncture tip

[0742] 24', 24"24 ends

[0743] 25 Sealing lip

[0744] 25' sealing element

[0745] 26 Sealing lip

[0746] 26' sealing element

[0747] 27 Sealing lip

[0748] 27' sealing element

[0749] 28 Cylindrical wall

[0750] 28' 28' outer surface

[0751] 29 Sealing lip

[0752] 29' sealing element

[0753] 30 28 inner surface

[0754] 31 Piercing tip receiving end

[0755] 31'12 end

[0756] 31” points

[0757] 32 inner wall

[0758] End of 32'32

[0759] 33 grooves

[0760] 33'33 opening

[0761] 34 Nose

[0762] 35 rings

[0763] 36 32 outer surface

[0764] 37 12 inner surface

[0765] 38 Space

[0766] 39 end

[0767] 40 belly plate

[0768] End of 40'33

[0769] 41 wall

[0770] 42 belly plate

[0771] 43 base

[0772] 110 Ejector

[0773] 111 Fluid

[0774] 112 housing

[0775] 113 casing part

[0776] 114 proximal

[0777] 115 proximal part

[0778] 116 Remote

[0779] 117 Thickened distal part

[0780] 118 discharge section

[0781] 120 discharge passage

[0782] 121 distal cylindrical portion

[0783] 122 Entrance Opening

[0784] 124 Exit Opening

[0785] 126 bracket

[0786] 127 flange

[0787] 128 receiving space

[0788] 129 Shoulders

[0789] 130 piercing tip

[0790] 131 outer surface

[0791] 132 flow channels

[0792] 133a, 33b surface lines

[0793] 134 Container

[0794] 136 Vertex

[0795] 138 inner contour

[0796] 139 spine

[0797] 140 protrusion

[0798] 141 Fluid Reservoir

[0799] 142 seals

[0800] 143 thorn-like protrusions

[0801] 144 Wing-like protrusion

[0802] 146 pins

[0803] 147 slots

[0804] 148 Fixing devices

[0805] 149a Circumferential part

[0806] 149b Longitudinal section

[0807] 210 Ejector

[0808] 211 housing

[0809] 213 longitudinal axis

[0810] 215 discharge device

[0811] 217 Entrance Opening

[0812] 218 Entrance Path

[0813] 219 Exit Opening

[0814] 221 bracket

[0815] 221a Proximal cylindrical portion

[0816] 221b distal cylindrical portion

[0817] 221c Transition

[0818] 222 grooves

[0819] 223 Receiving Space

[0820] 225 Container

[0821] 227 Fluid

[0822] 229 Activation Device

[0823] 231 seals

[0824] 233 Bracket insertion opening

[0825] 235 Proximal portion of discharge device

[0826] 237 Distal opening of bracket

[0827] 239 Receiving Space

[0828] 241 wall section

[0829] 243a Pin

[0830] 243b slot

[0831] 245 Proximal section of the inner wall

[0832] 247 Protrusion

[0833] 249 flange

[0834] 251 Tip

[0835] 253 tubes

[0836] 255 distal portion of the discharge device

[0837] 257 Casing section of discharge device

[0838] 301 Syringe

[0839] 302 Hollow body

[0840] 303 Piston

[0841] 304 Middleware

[0842] 305 Hollow body

[0843] 321 Hollow body surface

[0844] 322 access

[0845] 323 rear body opening

[0846] 324 front body opening

[0847] 325 first needle seat

[0848] 326 needle cannula

[0849] 331 front piston opening

[0850] 332 rear piston end

[0851] 333 Middle Wall

[0852] 334 Receiving Room

[0853] 335 Separation elements, membranes

[0854] 336 Room 1

[0855] 337 Room 2

[0856] 341 Second needle seat

[0857] 342 Supply Space

[0858] 343 First Sealing Area

[0859] 343a First sealing area

[0860] 344 internal components

[0861] 345 External components

[0862] 346 support

[0863] 347 seals

[0864] 347a seal

[0865] 348 Spindle

[0866] 349 Edge

[0867] 351 Sealed Area

[0868] 352 Spring

[0869] 355 Pivoting or deflecting device, inclined surface, inclined plane

[0870] 410 Ejector

[0871] 412 discharge section

[0872] 414 proximal

[0873] 416 Remote

[0874] 417 Entrance Opening

[0875] 418 discharge passage

[0876] 420 Entrance Opening

[0877] 422 Exit Opening

[0878] 424 middle section

[0879] 425 sealing lip

[0880] 426 distal part

[0881] 427 stopper

[0882] 428 proximal part

[0883] 429 Remote

[0884] 430 Receiving Space

[0885] 432 Rupturable Section

[0886] 434 Activation Device

[0887] 435 dome-shaped outline

[0888] 436 flow channel

[0889] 437 protrusion

[0890] 438 receiving end

[0891] 440 Insert opening

[0892] 442 Transition

[0893] 444 protrusion

[0894] 446 distal part

[0895] 448 receiving end

[0896] 449 Opening

[0897] 450 containers

[0898] 451 Fluid Reservoir

[0899] 452 Fluid

[0900] 454 seals

[0901] 456 inner wall

[0902] 458 distal surface

[0903] 457 proximal

[0904] 459 inner wall

[0905] 1010 Allocator

[0906] 1011 Housing

[0907] 1013 Longitudinal Axis

[0908] 1015 Discharge device

[0909] 1017 Entrance Opening

[0910] 1018 Entrance Path

[0911] 1019 Apply Tip

[0912] 1021 Bracket

[0913] 1021a Proximal cylindrical portion

[0914] 1021b distal cylindrical portion

[0915] 1021c Transition Section

[0916] 1022 grooves

[0917] 1023 receiving space

[0918] 1025 Container

[0919] 1027 Fluid

[0920] 1029 Activation Device

[0921] 1031 Seals

[0922] 1033 Bracket insertion opening

[0923] 1035 Proximal portion of discharge device

[0924] 1037 distal opening of the bracket

[0925] 1039 Receiving Space

[0926] 1041 Wall Section

[0927] 1043a Pin

[0928] 1043b slot

[0929] 1045 Proximal section of inner wall

[0930] 1047 Protrusion

[0931] 1049 flange

[0932] 1051 Cutting Edge

[0933] 1053 tube

[0934] 1055 Distal portion of discharge device

[0935] 1057 Casing section of discharge device

[0936] 1060 Syringe

[0937] 1062 Plunger

[0938] 1064 cylinder

[0939] 1066 Piston

[0940] 1068 needle hub

[0941] 1070 rods

[0942] 1080 containers

[0943] 1082 handle

[0944] 1084 Closures

[0945] 1086 external thread

[0946] 1088 Neck

[0947] 1090 Fluid Reservoir

[0948] 1092 Outer container

[0949] 1094 containers

[0950] 1096 wall

[0951] 1098 wall

[0952] 1100 Seals

[0953] 1102 1094 inner surface

[0954] Inner surface of 1104 1080

[0955] 1106 1080 open end

[0956] 1108 membrane

[0957] 1120 Application device

[0958] 1122 Bracket

[0959] 1124 discharge opening

[0960] 1126 Pins

[0961] 1128 concave part

[0962] 1130 wall

[0963] 1132 Collar

[0964] Channel 1134

[0965] 1136 Storage Device

[0966] 1138 paragraphs

[0967] 1140 paragraphs

[0968] Room 1142

[0969] 1144 channel

[0970] 1146, 1146A, 1146B Seals, seals, seals

[0971] 1148 Seams

[0972] 1150 Storage Device

[0973] 1152 paragraphs

[0974] 1154 Area

[0975] 1100 Applicator

[0976] 1101 Support

[0977] 1102 end

[0978] 1103 access

[0979] 1200 Ejector

[0980] 1202 Outer shell parts

[0981] 1204 Inner shell parts

[0982] 1206 base

[0983] 1208 First end portion of 1204

[0984] 1210 Pin

[0985] 1212 Second end portion of 1204

[0986] 1214 Grip Plate

[0987] 1216 First end portion of 1202

[0988] 1218 Exit Opening

[0989] 1220 The second end portion of 120

[0990] 1222 Guidance Path

[0991] 1224 Piercing Tip

[0992] 1225 1224 outer surface

[0993] 1226 Sealing lip

[0994] 1228 Entrance

[0995] 1230 access

[0996] 1232 membrane

[0997] 1234 cylinder

[0998] 1236 Storage

[0999] 1238 Guide Nose

[1000] 1239 1204 outer surface

[1001] 1240 Guide Nose

[1002] 1242 1202 inner surface

[1003] 1246 Storage Department

[1004] 1248 First Branch

[1005] 1250 Second Branch

[1006] 1252 Third Branch

[1007] 1254 Fourth Branch

[1008] 1256 Seating

[1009] 1258 Fifth Branch

[1010] 1260 End Stop

[1011] 1262 Sealing Surface

[1012] 1264 Sealing Surface

[1013] 1266 Laser Welding

[1014] 1268 Metal Inserts

[1015] 1270 Plastic Insert

[1016] 1272 1230 wall

[1017] A1 First longitudinal axis

[1018] A2 Second longitudinal axis

[1019] A L longitudinal axis

[1020] A Longitudinal axis

[1021] B arrow

[1022] F Fluid

[1023] L length

Claims

1. An ejector (1) comprising a dispensing element (2) and a housing (3), the housing (3) having a static piston (10) connected at least in a fluid-conducting manner to the dispensing element (2), and wherein the static piston (10) is arranged in the housing (3); the ejector (1) further comprising a container (4) containing a fluid (F), the container (4) being movable relative to the static piston (10) and the housing (3), wherein the static piston (10) comprises a piercing tip (24) adapted to pierce a membrane (13) or a seal of the container (4) when the container (4) is moved towards the housing (3), wherein the static piston (10) further comprises a piercing tip (24) arranged at a position adjacent to the housing (3) at least one sealing element (25', 26', 27') in the region of the piercing tip (24), wherein when the movable container (4) is moved relative to the housing (3) into a position in which the membrane (13) or seal is pierced and in which the at least one sealing element (25', 26', 27') engages an inner surface (37) of the container (4), the at least one sealing element (25', 26', 27') provides a seal between the piercing tip (24) and the inner surface (37) to prevent the fluid (F) from passing between the at least one sealing element (25', 26', 27') and the inner surface (37) and into a portion of the housing (3), wherein The fluid (F) is a medical fluid, in particular a medical fluid comprising lipid nanoparticles.

2. The discharger according to claim 1, wherein The at least one sealing element (25', 26', 27') is arranged at an end (24') of the piercing tip (24) remote from the other end (24") of the piercing tip (24) comprising the inlet (23) of the dispensing element (2).

3. The discharger according to claim 2, wherein The membrane (13) or seal is configured to be pierced by the other end of the piercing tip (24) comprising the inlet (23).

4. Eductor according to at least one of the preceding claims, wherein The at least one sealing element is a sealing lip (25, 26, 27).

5. Eductor according to at least one of the preceding claims, wherein The diameter of the first sealing element (25') is smaller than the diameter of the second sealing element (26'), and if a third sealing element (27') is provided, the diameter of the first sealing element (25') is smaller than the diameter of the third sealing element (27'), wherein the second and third sealing elements (26', 27') preferably have at least substantially the same diameter.

6. The discharger according to claim 5, wherein The outer diameter of the first sealing element (25') is smaller than or equal to the inner diameter of the container (4), and the outer diameters of the second sealing element (26') and optionally the third sealing element (27') are larger than the inner diameter of the container (4).

7. Eductor according to at least one of the preceding claims, wherein First, second and preferably third sealing lips (25, 26, 27) are provided, all of which are configured to engage the inner surface (37) to prevent the fluid (F) from passing into the portion of the housing (3).

8. The discharger according to claim 7, wherein The first, second and preferably third sealing lips (25, 26, 27) are arranged parallel to one another in succession along the longitudinal axis (A) of the ejector (1).

9. Eductor according to at least one of the preceding claims 2 to 8, wherein The diameter of the puncture tip decreases from the at least one sealing element (25', 26', 27') to the other end (24") of the puncture tip (24) comprising the inlet (23).

10. The discharger according to at least one of the preceding claims, wherein The container (4) comprises in its interior a compartment (12) in which the fluid (F) is initially stored before piercing the membrane (13) or seal, and wherein the inner surface (37) is present at a wall (32) of the compartment (12).

11. The discharger according to claim 10, wherein The container (4) further comprises an outer wall (14) arranged parallel to the wall (32) of the compartment (12) and a guide groove (33) present between the outer wall (14) and the wall (32) of the compartment (12), wherein the guide groove (33) receives at least a portion of the shell (3).

12. The discharger according to claim 10 or claim 11, wherein The compartment (12) comprises an end (31') which is arranged opposite the membrane (13) or the seal and which is configured to be substantially complementary to the shape of the puncture tip (24).

13. The ejector according to at least one of the preceding claims, wherein The ejector includes a child safety lock.

14. The discharger according to claim 14, wherein The child safety lock is formed between the container (4) and the housing (3).

15. Eductor according to at least one of the preceding claims, wherein In the storage state of the discharger (1), the at least one sealing element (25', 26', 27') does not contact the housing (3), and wherein in the discharge state or the post-discharge state of the discharger (1), the at least one sealing element (25', 26', 27') only contacts the inner surface (37).

16. Eductor according to at least one of the preceding claims, wherein The inner surface (30) of the cylindrical wall (28) of the housing (3) includes a further inwardly projecting sealing lip (29) configured to engage a surface (36) of the container (4) that is different from the inner surface (37).

17. A method for discharging a fluid (F) from a discharger (1), in particular a discharger according to at least one of claims 1 to 16, comprising the following steps: - guiding the container (4) in the direction along the longitudinal axis (A) of the discharger (1) towards the piercing tip (24) of the static piston (10) housed in the housing (3) of the discharger (1), - piercing a membrane (13) or a seal present at the container (4) by means of the piercing tip (24), thereby causing the membrane (13) or the seal to be pierced, in particular initially at the center of the membrane (13) or the seal, - further guiding the container (4) towards the static piston (10) and bringing the inner surface (37) of the container (4) into engagement with at least one sealing element (25', 26', 27') arranged at the piercing tip (24) of the static piston (10) to prevent the fluid (F) from passing between the at least one sealing element (25', 26', 27') and the inner surface (37) and thereby entering a portion of the housing (3), and - discharging the fluid (F) via the outlet (7) of the discharger (1), wherein the fluid (F) is a medical fluid, in particular a medical fluid comprising lipid nanoparticles.

18. A container (4) for a manually operated discharger (1), wherein The container (4) comprises a compartment (12) for a fluid (F), and a longitudinal axis (A), wherein the compartment (12) is configured to be: on the one hand sealed and isolated by at least one wall (32, 41, 14) of the compartment (12), the at least one wall (32) extending peripherally at least regionally around the longitudinal axis (A); and on the other hand being sealed and isolated by a seal (13") at the front end (13"') of the container (4), wherein the container (4) is a double-walled container (4) which, in addition to the wall (32) of the compartment (12), further comprises an outer wall (14) extending around the wall (32) of the compartment (12), wherein a groove (33) is formed between the outer wall (14) and the wall (32) of the compartment (12), and wherein at least one connecting web (40) preferably fixedly connects the outer wall (14) to the wall (32) of the compartment (12), wherein the container (4) is filled with a fluid (F), and wherein the fluid (F) is a medical fluid, in particular a medical fluid comprising lipid nanoparticles.

19. The container (4) according to claim 18, wherein The wall (32) of the compartment (12) and the outer wall (14) of the preferably cylindrical container (4) are injection moulded in one piece from the same material.

20. The container (4) according to claim 19, wherein The length of the groove (33) is at least 50%, preferably 70% to 95% of the length of the outer wall (14) in the direction of the longitudinal axis (A) of the container (4).

21. Container (4) according to at least one of the preceding claims 18 to 20, wherein The groove (33) is open at the front end (13'); and / or wherein the front end (13') coincides with a plane (13') comprising at least one of an end (32') of the compartment wall (32), an end (14') of the outer wall (14), the seal (13') and the opening (33') of the groove (33).

22. Container (4) according to at least one of the preceding claims 18 to 21, wherein The rear end portion (21) of the container (4) includes a recess (22) formed therein, preferably wherein: The recess (22) is configured to receive a finger or thumb of a user.

23. Container (4) according to at least one of the preceding claims 18 to 22, wherein The end (31') of the compartment (12) arranged opposite the front end (13') is formed by a further wall (41) of the compartment (12), wherein the further wall (41) converges from the wall (32) of the compartment (12) to a common point (31") forming the end (31') of the compartment (12), the common point preferably coinciding with the longitudinal axis (A).

24. A container (4) according to claim 23, when dependent on claim 22, preferably when dependent on claim 20, wherein The end (31') of the compartment (12) is set back from the rear end (21) of the container (4) by at least 20%, in particular 25% to 45%, of the length of the outer wall (14).

25. A container (4) according to claim 23 or claim 24, when dependent on claim 22, wherein A further web (42) is provided, extending parallel to the outer wall (14) between the end (31') of the compartment (12) and the rear end (21) of the container (4), wherein the further web (42) in particular forms a base (43) of the recess (22).

26. The container (4) according to any one of claims 23 to 25, wherein The wall (32) of the compartment (12) extends parallel to the outer wall (14) beyond the end (31') of the compartment (12).

27. Container (4) according to at least one of the preceding claims 18 to 26, at least one groove (16) being formed in the outer wall (14), wherein The groove extends from the recess (33) to the outer surface (14") of the outer wall (14).

28. The container (4) according to claim 27, wherein The at least one groove (16) comprises two longitudinal sections (17, 17') which are parallel to each other and offset parallel to the longitudinal axis (A) and are connected to each other via a connecting section (18).

29. Container (4) according to at least one of the preceding claims 18 to 28, wherein The seal (13") of the container (4) is configured to be pierced.

30. Container (4) according to at least one of the preceding claims 18 to 29, wherein The compartment (12) is configured to store a fluid.

31. An ejector comprising a container according to at least one of the preceding claims 18 to 30 and further comprising a housing (3) and a static piston (10), wherein The container (4) is configured to move relative to the housing (3) and the static piston (10) between a storage state, a discharge state, and a post-discharge state, wherein in the storage state, the discharge state, and the post-discharge state, at least a portion of the housing (3) is received in the groove (33), and wherein the groove (33) is preferably configured to receive a cylindrical wall (28) of the housing (3) and permit movement of the cylindrical wall therein so as to guide the container (4) relative to the housing (3), and in particular wherein the groove (33) is configured to receive the housing (3) to a greater extent in the discharge state than in the storage state, and in particular to receive the housing (3) to a greater extent in the post-discharge state than in the discharge state.

32. The discharger according to claim 31, wherein The static piston (10) includes at least one sealing element (25', 26', 27') configured to engage an inner surface (37) of the compartment (12) when the discharger (1) is in one of the discharge state and the post-discharge state.

33. An ejector according to claim 31 or claim 32, wherein The housing (3) includes a sealing element (29') at an inner surface (30) thereof, wherein the sealing element (29') is configured to engage an outer surface (36) of the compartment (12) when the discharger (1) is in one of the discharge state and the post-discharge state.

34. A method of assembling an emitter according to at least one of claims 31 to 33, comprising the steps of: - introducing at least a portion of the housing (3) into the recess (33) of the container (4), - filling said container with said fluid (F), and - axially displacing the container (4) relative to the housing (3) along the longitudinal axis (A).

35. The method according to claim 34, It further comprises the following steps: - subsequently rotating the container (4), and - Upon rotation to reach the storage position of the drain (1), a child safety lock is activated.

36. An ejector (1) comprising a dispensing element (2) and a housing (3), the housing (3) having a static piston (10) connected at least in a fluid-conducting manner to the dispensing element (2), and wherein the static piston (10) has a piercing tip (24) and is arranged in the housing (3); the ejector (1) being configured to receive at least a portion of a container (4) for containing a fluid (F), wherein the container (4) is then movable relative to the static piston (10) and the housing (3) along a longitudinal direction (A) of the ejector (1), wherein The housing (3) comprises a sealing element (29') arranged at an inner surface (30) of the housing (3), wherein the sealing element (29') protrudes from the inner surface (30) of the housing (3) in the direction of the longitudinal direction (A) of the discharger (1), wherein the container (4) is filled with a fluid (F), and wherein the fluid (F) is a medical fluid, in particular a medical fluid comprising lipid nanoparticles.

37. The discharger according to claim 36, wherein The housing (3) has a cylindrical wall (28) having the inner surface (30), and the sealing element (29') is arranged to extend circumferentially around the inner surface (30) of the cylindrical wall (28).

38. An ejector according to claim 36 or claim 37, wherein The sealing element (29') is arranged on the inner surface (30) of the housing (3) in the region of the puncture tip (24).

39. Eductor according to at least one of the preceding claims 36 to 38, wherein The sealing element (29') is an inwardly protruding sealing lip (29).

40. Eductor according to at least one of the preceding claims 36 to 39, wherein The sealing element (29') protrudes in the direction of the puncture tip (24) arranged along the longitudinal direction (A).

41. Eductor according to at least one of the preceding claims 36 to 40, wherein The sealing element (29') is arranged in a plane perpendicular to the longitudinal direction (A), wherein the plane further includes at least one of the puncture tip (24), the end (24") of the puncture tip and the inlet (23) of the puncture tip (24).

42. Eductor according to at least one of the preceding claims 36 to 41, wherein The sealing element (29') is either integrally formed at the inner surface (30) of the cylindrical wall (28) or is in contact with the inner surface (30) of the cylindrical wall (28).

43. Eductor according to at least one of the preceding claims 36 to 42, wherein The static piston (10) comprises at least one further sealing element (25', 26', 27') arranged at the piercing tip (24).

44. The discharger according to at least one of the preceding claims 36 to 43, further comprising the container (4), wherein The sealing element (29') is in contact with or connected to the housing (3) only in the storage state of the discharger (1).

45. The discharger of claim 44, wherein The container (4) does not contact the sealing element (29') in the storage state of the discharger (1).

46. ​​An emitter according to claim 44 or claim 45, wherein The sealing element (29') is configured to engage the container (4) in at least one of the discharge state and the post-discharge state of the discharger (1) in addition to being in contact with or connected to the housing (3) in both the discharge state and the post-discharge state of the discharger (1).

47. An ejector according to any one of claims 44 to 46, wherein The container (4) includes a seal (13"), wherein the piercing tip (24) is configured to pierce the seal (13") of the container (4) when the container (4) is removed from the storage state and moved toward the housing (3).

48. The ejector of claim 47, wherein The sealing element (29') is configured to engage the container (4), preferably the surface (36) of the container (4), upon contact of the seal (13") of the container (4) with the piercing tip (24).

49. An emitter according to claim 47 or claim 48, wherein The static piston (10) comprises at least one further sealing element (25', 26', 27') arranged at the piercing tip (24), and when the movable container (4) is moved relative to the housing (3) into a position in which the seal (13") is pierced, the at least one further sealing element (25', 26', 27') provides a seal between the piercing tip (24) and an inner surface (37) of the container (4), wherein the inner surface (37) is different from the surface (36) of the container (4), in particular wherein the at least one further sealing element (25', 26', 27') is a sealing lip (25, 26, 27).

50. An ejector according to any one of claims 47 to 49, wherein The container (4) comprises in its interior a compartment (12) in which the fluid (F) is initially stored before piercing the seal (13"), and wherein the surface (36) is the outer surface (36) of the wall (32) of the compartment (12).

51. The discharger according to claim 50, wherein The container (4) further comprises an outer wall (14) arranged parallel to the wall (32) of the compartment (12) and a guide groove (33) present between the outer wall (14) and the wall (32) of the compartment (12), wherein the guide groove (33) is configured to receive at least a portion of the shell (3).

52. Eductor according to at least one of the preceding claims 36 to 51, wherein The ejector (1) includes a child safety lock.

53. Eductor according to at least one of the preceding claims 47 to 52, wherein The seal (13") is designed as a membrane (13).

54. A method for discharging a fluid (F) from a discharger (1), in particular according to at least one of claims 36 to 53, comprising the following steps: - guiding the container (4) in the longitudinal direction (A) of the discharger (1) towards the piercing tip (24) of the static piston (10) housed in the housing (3) of the discharger (1), - piercing a seal (13") present at the container (4) by means of the piercing tip (24), thereby causing the seal (13") to be pierced, in particular initially at the center of the seal (13"), - engaging the outer surface (36) of the container (4) with at least one sealing element arranged at the inner surface (30) of the housing to prevent the passage of the fluid (F) between the at least one sealing element (29') and the outer surface (36), and preferably - further directing the container (4) towards the static piston (10) to discharge the fluid (F) via the outlet (7) of the discharger (1), wherein the fluid (F) is a medical fluid, in particular a medical fluid comprising lipid nanoparticles.

55. A discharger (110) for discharging a predetermined amount of fluid (111), the discharger comprising: a housing (112) defining a longitudinal first axis (A1) and having a proximal end (114) and a distal end (116), a discharge section (118) having a discharge passage (120) for the fluid (111) extending between an inlet opening (122) and an outlet opening (124) of the discharge section (118), a carriage (126) cooperating with the proximal region (114) of the housing (112) such that the carriage (126) is movable relative to the housing (112) along the first axis (A1), the carriage (126) comprising a receiving space (128) for the fluid, and a piercing tip (130) having a flow channel (132) for establishing a flow connection for the fluid (111) from the receiving space (128) to the inlet opening (122) of the discharge section (118), the piercing tip (130) defining a centrally extending longitudinal second axis (A2) and having a shell surface (131), wherein the shell surface (131) of the puncture tip (130) has a substantially convexly curved configuration, in particular a dome-shaped configuration, wherein the discharger (110) is filled with a fluid (F), and wherein the fluid (F) is a medical fluid, in particular a medical fluid comprising lipid nanoparticles.

56. The ejector of claim 55, wherein The flow channel (132) is centrally located within the puncture tip (130) and extends along the second axis (A2), or the flow channel (132) is located at an offset position relative to the second axis (A2).

57. The ejector according to claim 55 or 56, wherein The puncture tip (130) is substantially rotationally symmetric about the second axis (A2).

58. An emitter according to any one of claims 55 to 57, wherein The shape of the puncture tip (130) in a longitudinal section along the second axis (A2) is defined by two surface lines (133a, 133b) intersecting at an angle (α), which is between 70° and 110°, preferably between 80° and 100°, more preferably between 85° and 95°, and in particular approximately 90°.

59. An ejector according to any one of claims 55 to 58, wherein The shape of the puncture tip (130) in a longitudinal section along the second axis (A2) is defined by two surface lines (133a, 133b), each surface line (133a, 133b) having a diameter greater than the diameter (D) of the puncture tip (130) at its widest point. W ) is defined by at least one segment (S2) having a curvature radius (R1).

60. The ejector of claim 59, wherein The curvature radius (R1) has a diameter (D W ), preferably between 1.01 times and 1.50 times, preferably between 1.05 times and 1.140 times, more preferably between 1.110 times and 1.130 times, in particular approximately 1.120 times the length.

61. An emitter according to any one of claims 55 to 60, wherein The piercing tip (130) is defined in a longitudinal section along the second axis (A2) by two surface lines (133a, 133b), each surface line (133a, 133b) having at least two sections (S1, S2) of different curvature radii (R1, R2).

62. An emitter according to any one of claims 55 to 61, wherein The piercing tip (130) includes a ridge (139) at its apex (136).

63. The discharger of claim 62, wherein The ridge (139) is perpendicular to the second axis (A2).

64. The ejector according to claim 61 or 62, wherein The ridge (139) is interrupted by the flow channel (132), so that two protrusions (140) are formed adjacent to the flow channel (132).

65. An ejector according to any one of claims 61 to 64, wherein The ridge (139) is deformable.

66. An emitter according to any one of claims 55 to 65, wherein The piercing tip (130) is at least partially positioned within the housing (112) so as to protrude into the receiving space (128) when the carriage (126) moves toward the distal end (116) of the housing (112).

67. An emitter according to any one of claims 55 to 66, wherein The inner contour (138) of the receiving space (128) or the inner contour (138) of the container (134) is substantially complementary in shape to the piercing tip (130), the container being adapted to be loaded into the receiving space (128) and containing a quantity of fluid (111).

68. An exhaust system comprising: - an ejector (110) according to any one of claims 55 to 67, and - at least one container (134) containing a quantity of fluid (111) to be discharged, wherein said container (134) is adapted to be loaded into a receiving space (128) of a bracket (126) of said discharger (110).

69. Use of the discharger according to any one of claims 55 to 67 or the discharge system according to claim 68 for discharging a fluid (111) comprising at least one pharmaceutical, dental or veterinary agent, wherein In particular, the amount of the fluid (111) is in the range of 0.1 ml to 110 ml.

70. An ejector, in particular a non-reusable syringe, for ejecting a predetermined amount of a fluid, in particular a liquid comprising at least one medical, dental or veterinary agent, said ejector comprising: - a housing (211) defining a longitudinal axis (213) and having a proximal end and a distal end, a discharge device (215) at least partially arranged inside the housing (211) and having an inlet opening (217) and an outlet opening (219) inside the housing, the discharge device (215) further defining a discharge passage for the fluid extending between the inlet opening (217) and the outlet opening (219), a carriage (221) received in the proximal region of the housing (211) and movable relative to the housing along the longitudinal axis between a starting position and a final discharge position, wherein, in the starting position, the bracket (221) protrudes from the proximal end of the housing so as to be pushed further into the housing (211) by a user and toward the final discharge position, and wherein the carrier (221) defines a receiving space (223) adapted to be loaded with a separate container (225) containing a quantity of fluid (227) to be discharged, and - activation means (229) for establishing a flow connection for the fluid from within the receiving space (223) of the carriage (221) to the inlet opening (217) of the discharge device (215), the activation means (229) being inoperative when the carriage (221) is in the starting position and being suitable for establishing the flow connection when the carriage (221) is in the final discharge position or is moving towards the final discharge position, wherein the discharge vessel is filled with a fluid (F), and wherein the fluid (F) is a medical fluid, in particular a medical fluid comprising lipid nanoparticles.

71. The discharger according to claim 70, in, automatically establishing a flow connection by moving the carriage (221) towards the final discharge position, and / or The flow connection is established before the bracket (221) reaches the final discharge position.

72. The discharger according to claim 70 or 71, in, The activation means (229) is positioned inside the housing (211) so as to project into the receiving space (223) when the bracket (221) moves from the starting position toward the final discharge position, and / or, Therein, the activation means (229) is provided with means for rupturing the seal (231), in particular for piercing, penetrating, puncturing and / or perforating the seal (231).

73. The discharger according to any one of the preceding claims 70 to 72, in, The carrier (221) has a proximal end with an insertion opening (233), the receiving space (223) being accessible through the insertion opening, and wherein the carrier is adapted to be loaded with the container (225) by sliding the container through the insertion opening into the receiving space, and / or Wherein, the discharge device (215) is adapted to guide the bracket (221) along the longitudinal axis when the bracket (221) moves from the starting position toward the final discharge position.

74. The discharger according to any one of the preceding claims 70 to 73, in, The discharge device (215) has a proximal portion (235) which is substantially facing the receiving space (223), the activation means (229), and an inlet opening (217) formed at or integrated into the proximal region, and / or wherein the discharge device (215) has a proximal portion (235) including the inlet opening (217), and wherein the bracket (221) has a distal opening (237), the discharge device extending with its proximal portion through the distal opening into the bracket, In particular, the proximal portion (235) of the discharge device (215) is sealingly fitted into the bracket (221) so as to at least substantially prevent leakage of fluid through the distal opening (237) of the bracket.

75. The discharger according to claim 74, in, The outer diameter of the proximal portion (235) of the discharge device (215) is smaller than the inner diameter of the bracket (221) in the area of ​​the receiving space (223) so as to provide a receiving space (2239) for the wall portion (241) of the container (225), which is arranged around the proximal portion of the discharge device when the bracket moves towards the final discharge position.

76. The discharger according to any one of the preceding claims 70 to 75, in, The bracket (221) generally has a multi-cylindrical shape comprising at least a proximal cylindrical portion (221a) and a distal cylindrical portion (221b), the proximal cylindrical portion defining a receiving space (223) for the container (225), In particular, the outer diameter of the proximal cylindrical portion (221a) of the bracket (221) is greater than the outer diameter of the distal cylindrical portion (221b) of the bracket (221).

77. The discharger according to claim 76, in, The inner diameter of the proximal cylindrical portion (221a) of the bracket (221) is greater than the inner diameter of the distal cylindrical portion (221b) of the bracket (221), and / or Wherein, inside the bracket (221), a transition portion (221c) is arranged between the proximal cylindrical portion (221a) and the distal cylindrical portion (221b), and the transition portion (221c) defines the distal end of the receiving space (223) and serves as a stopper for a container (225) loaded into the receiving space.

78. The discharger according to any one of the preceding claims 70 to 77, It further comprises fixing means (243) adapted to prevent the carriage (221) from unintentionally moving from the starting position along the longitudinal axis (213), In particular, The fixing means (243) comprises a pin / slot arrangement having at least one pin (243a) formed at the bracket (221) and at least one slot (243b) formed in the wall (211a) of the housing (211), the pin (243a) being guided by the slot (243b), In particular, the groove (243b) includes a portion extending parallel to the longitudinal axis (213) and a portion extending in a plane not extending parallel to the longitudinal axis (213).

79. A container (225), in particular in the form of a cartridge or capsule, for an emitter (210) according to any one of the preceding claims 70 to 78, The container (225) comprises a predetermined amount of fluid (227) to be discharged by the discharger, in particular a liquid comprising at least one pharmaceutical, dental or veterinary agent, in particular wherein The container (225) has a generally cylindrical outer shape.

80. The container according to claim 79, in, The fluid (227) inside the container (225) is protected from the environment by a rupturable seal (231), and / or The container (225) has a distal end surface, at least a portion of which is formed by a rupturable seal (231).

81. A discharge system comprising a discharger (210) according to any one of claims 70 to 78 and at least one container (225) according to claims 79 to 80, in, The container (225) is loaded or adapted to be loaded into the carriage (221) of the discharger.

82. The exhaust system according to claim 81, in, The discharge device (215) of the discharger (210) has a proximal portion (235) including the inlet opening (217), when the bracket (221) of the discharger (210) is moved towards the final discharge position, the proximal portion sealingly fitting into the container (225) so as to at least substantially prevent the fluid from leaking out of the container (225) past the discharge device (215), and / or wherein the container (225) has a wall portion (241) having a thickness at least approximately the same as the difference between the inner diameters of the proximal cylindrical portion (221a) and the distal cylindrical portion (221b) of the bracket (221) of the discharger (210).

83. An exhaust system according to claim 81 or 82, in, The discharge device (215) of the discharger (210) has a proximal portion (235) including the inlet opening (217), and the container (225) has an inner wall that defines the fluid space of the container, the inner wall including a proximal section (245), and wherein the proximal portion (235) of the discharge device (215) and the proximal section (245) of the inner wall are shaped to be at least approximately complementary to each other so as to minimize the amount of residual fluid contained in the fluid space of the container (225) when the bracket (221) of the discharger (210) is in the final discharge position.

84. Use of a drain according to any one of claims 70 to 78 or a drain system according to any one of claims 82 to 83 for draining a liquid comprising at least one pharmaceutical, dental or veterinary agent, wherein In particular, the amount of liquid lies in the range of 0.2 ml to 2 ml and is preferably approximately 0.5 ml.

85. A syringe (301), comprising: - a hollow body (302) having an enclosing hollow body surface (3321) and forming a passage (322) therein, wherein an axis (A) is formed along an axial longitudinal direction of the hollow body (302), and the passage (322) has a rear body opening (323) and a front body opening (324) arranged opposite to each other along the longitudinal direction, wherein a first needle seat (325) is formed at the front body opening (324), a needle cannula (326) is arranged in the needle seat, and the needle cannula (326) is movable relative to the needle seat along the axis (A); a piston (303) arranged in the hollow body (302) and movable in the passage (322) along the axis (A), wherein the piston (303) comprises a front piston opening (3331), a rear piston end (332) and a surrounding intermediate wall (333) arranged between the front piston opening (331) and the rear piston end (332) and forming a receiving chamber (334) for receiving at least one fluid; and an intermediate piece (304) arranged in the receiving chamber (334) and movable along the axis (A), wherein a first sealing area (343; 343a) which seals the receiving chamber (334) in the storage position acts between the intermediate wall (333) and the intermediate piece (304), wherein a second needle seat (341) and a supply space (342) are formed in the intermediate piece (304), wherein the second needle seat (341) and the supply space (342) are in flow communication; wherein the piston (303), the hollow body (302) and the intermediate piece (304) are movable into a release position by means of a coaxial relative movement starting from the storage position; and wherein, in the storage position, a seal (347; 343a) is arranged between the supply space (342) and the receiving chamber (334), and the seal can be released by the coaxial relative movement so that the receiving chamber (334) and the supply space (342) are in flow communication in the release position, wherein the syringe (301) is filled with a fluid (F), and wherein the fluid (F) is a medical fluid, in particular a medical fluid comprising lipid nanoparticles.

86. The syringe of claim 85, wherein The intermediate piece (304) comprises an outer element (345) and an inner element (344), and the inner element (344) is axially movable relative to the outer element (345) to release the seal (347), wherein the inner element (344) in particular comprises the second needle seat (341).

87. The syringe of claim 86, wherein The inner element (344) comprises a seat (346) for the outer element (345), wherein, in particular, the inner element (344) is arranged together with the seat (346) so that an axial movement of the inner element (344) relative to the outer element (345) is limited by the seat (346) in the direction of the rear body end (323).

88. The syringe of claim 86 or claim 87, wherein The seal (347) is formed between the inner member (344) and the outer member (345).

89. The syringe according to any one of the preceding claims, wherein The receiving chamber (334) is divided into a first chamber (336) and a second chamber (337) by means of a separation element (335), wherein the first chamber (336) is arranged between the second chamber (337) and the intermediate piece (304), wherein, in the flush position, the second chamber (337) and the supply space (343) are in particular in flow communication.

90. The syringe of claim 89, wherein In the storage position, a sealing area (351) is formed and arranged between the intermediate wall (333) and the separating element (335), so that the second chamber (337) and the supply space (342) do not have any flow communication.

91. The syringe of claim 89 or 90, wherein The separation element (335) is designed as a membrane.

92. The syringe of any one of claims 89 to 91, wherein The intermediate piece (304) is formed as a spindle (348) in the direction of the rear body end (323) to break open the separation element (335).

93. The syringe of any one of claims 89 to 92, wherein The separating element (335) is designed as a plug and is arranged in the receiving chamber (334) so ​​as to be movable along the axis (A).

94. The syringe according to any one of claims 85 to 93, wherein The intermediate piece (304) is constructed in one part and is axially movable relative to the piston (303) for releasing the seal (343a).

95. The syringe according to any one of claims 85 to 94, wherein The inner element (344) is configured as a further hollow body (305), and the piston (303) is movably arranged in the further hollow body (305).

96. The syringe according to any one of the preceding claims 85 to 95, wherein A spring (352) is arranged in the passage (322), and the piston (303) can move in the direction of the front body opening (324) of the hollow body (302) against the restoring force of the spring.

97. The syringe according to any one of the preceding claims 85 to 96, wherein The receiving chamber (334) contains at least one fluid, in particular a liquid containing at least one medicament to be dispensed, in a first chamber (336) of the receiving chamber (334) and a flushing solution in a second chamber (337) of the receiving chamber (334).

98. The syringe according to any one of claims 85 to 97, wherein A device (355) is provided for automatically pivoting or deflecting the intermediate piece (304) laterally in the end position, wherein the device (355) acts in particular between the rear end of the receiving chamber (334) and the intermediate piece (304) and in particular comprises at least one inclined surface (355) or defines at least one inclined plane (355).

99. Use of a syringe according to any one of the preceding claims 85 to 98 for discharging a fluid already contained in the receiving chamber (334) without aspirating said fluid, in particular for injecting a liquid containing at least one medicament to be dispensed, wherein In a first phase, a liquid containing at least one medicament to be dispensed is discharged from a first chamber (336) of the receiving chamber (334), and then in a second phase, a flushing solution is discharged from a second chamber (337) of the receiving chamber (334).

100. An ejector (410), in particular a non-reusable syringe, for ejecting a predetermined amount of a fluid (452), in particular a liquid comprising at least one pharmaceutical, dental or veterinary agent, from a separate container (450), the ejector (410) comprising: a discharge section (412) defining a longitudinal axis and having a proximal end (414) and a distal end (416) and having a discharge passage (418) for the fluid (452) extending between an inlet opening (420) and an outlet opening (422) of the discharge section, an intermediate section (424) comprising a distal portion (426) cooperating with the proximal end (414) of the discharge section (412) and a proximal portion (428) defining a receiving space (430) suitable for being loaded with the separate container (450) containing a quantity of fluid (452) to be discharged by the discharger (410), wherein the distal portion (426) and the proximal portion (428) are formed as one piece and interconnected by a rupturable section (432), and The discharger (410) is filled with a fluid (F), and the fluid (F) is a medical fluid, in particular a medical fluid comprising lipid nanoparticles.

101. The ejector of claim 100, wherein The rupturable section (432) includes a predetermined rupture region adapted to rupture when an axial force is applied to the intermediate section (424).

102. The discharger according to claim 100 or 101, wherein After the ruptureable section (432) ruptures, the proximal portion (428) of the intermediate section (424) is movable relative to the distal portion (426) of the intermediate section (424) along the longitudinal axis between a starting position and a final discharge position.

103. The ejector of claim 102, wherein: In the starting position, the proximal portion (428) of the intermediate section (424) at least partially protrudes from the distal portion (426) of the intermediate section (424) and receives the distal portion (426) to be guided through the proximal portion (428) as the proximal portion (428) moves toward the distal end (416) of the discharge section (412) and toward the final discharge position.

104. An emitter according to any one of claims 100 to 103, wherein The distal portion (426) of the intermediate section (424) includes an activation device (434) for establishing a flow connection for the fluid (452) from the receiving space (430) of the proximal portion (428) of the intermediate section (424) to the inlet opening (420) of the discharge section (412).

105. The ejector of claim 104 and claim 102 or 103, wherein After the rupture of the rupturable section (432), the flow connection is automatically established by moving the proximal portion (428) of the intermediate section (424) relative to the distal portion (426) of the intermediate section (424) along the longitudinal axis from the starting position toward the distal end (416) of the discharge section (412) and toward the final discharge position.

106. The ejector of claim 105, wherein Prior to rupturing of the rupturable section (432) and / or in the initial position, the activation device (434) is inoperable.

107. The ejector of claim 106, wherein The activation device (434) is at least partially positioned inside the proximal portion (428) of the intermediate section (424) so ​​as to protrude into and beyond the receiving space (430) when the proximal portion (428) moves from the starting position toward the final discharge position.

108. The ejector according to any one of claims 104 to 107, wherein The activation means (434) is sealingly fitted within the proximal portion (428) of the intermediate section (424) to at least substantially prevent leakage of fluid through the rupturable section (432) after rupture.

109. The ejector according to any one of claims 104 to 108, wherein The activation device (434) is formed to be at least approximately complementary to an inner wall portion (456) of a container (450) suitable for being loaded within the receiving space (430) so as to minimize the amount of residual fluid (452) contained within the container (450) when the proximal portion (428) of the intermediate section (424) is in the final discharge position.

110. An emitter according to any one of the preceding claims 100 to 109, wherein The distal portion (426) and the proximal portion (428) are adapted to maintain their structure after rupturing of the rupturable section (432).

111. The ejector according to any one of the preceding claims 100 to 110, wherein Upon rupturing of the rupturable section (432), the distal portion (426) is adapted to act as a piston that expels the fluid (452) stored in the separate container (450).

112. The ejector according to any one of the preceding claims 100 to 111, wherein The proximal portion (428) of the intermediate section (424) has a receiving end (438) with an insertion opening (440), the receiving space (430) being accessible through the insertion opening (440), and wherein the proximal portion (428) is adapted to be loaded with the container (450) by sliding the container (450) through the insertion opening (440) into the receiving space (430), and wherein the receiving space (430) is sized such that the container (450) at least partially protrudes from the proximal portion (428).

113. The ejector of claim 112, wherein: Inside the proximal portion (428) of the intermediate section (424), a transition portion (442) is provided, which serves as a stop for a container (450) loaded into the receiving space (430).

114. The discharger according to any one of the preceding claims 100 to 113, further comprising the container (450), in particular in the form of a cartridge or capsule, comprising a predetermined amount of fluid (452) to be discharged by the discharger (410), in particular wherein The container (450) has a generally cylindrical outer shape, and in particular wherein the fluid (452) inside the container (450) is protected from environmental influences by a rupturable seal (454), and / or wherein the container (450) has a distal face (458), at least a portion of which is formed by the rupturable seal (454).

115. An emitter according to any one of claims 100 to 113, wherein The discharge section (412) includes a protrusion (444), in particular, the protrusion is molded on the discharge section (412) or formed integrally with the discharge section.

116. Use of the discharger (410) according to any one of claims 1 to 416 for discharging a fluid (452) comprising at least one medicinal agent, wherein In particular, the amount of fluid (452) lies in the range of 0.1 ml to 5 ml and is preferably approximately 0.5 ml.

117. A dispensing device having a spray assembly, characterized in that For at least two liquid components, the spraying assembly (541, 542; 556, 557) is arranged together with the mixing assembly (539, 45; 549) inside a mixing and spraying head (503; 555), the spraying assembly comprising a vortex chamber (541; 556) and the mixing assembly being located in front of the vortex chamber, and the mixing and spraying head forming a unit is removably attached to a multi-component dispensing device, wherein the dispensing device is filled with a fluid (F), and wherein the fluid (F) is a medical fluid, in particular a medical fluid comprising lipid nanoparticles.

118. The device according to claim 117, characterized in that The mixing and spraying head (503; 555) is formed by a mixing and spraying member (8; 558; 561) connected to a transfer housing (7; 547).

119. Dispensing device according to claim 117 or 118, characterized in that The mixing assembly comprises an annular mixing chamber (539) having a sawtooth-shaped mixing element (45).

120. The dispensing device according to claim 119, characterized in that The mixing chamber (539) has a feed duct (543) for the components to be mixed and a feed passage (540) leading from there to the vortex chamber (541), and the mixing chamber has a mixing element (45) on its side opposite the bottom wall (544) of the mixing chamber in the closure (537) of the mixing and spraying part (508).

121. Dispensing device according to any one of claims 117 to 120, characterized in that The vortex chamber is arranged concentrically with the mixing chamber and opens into a spray outlet (542).

122. The dispensing device according to claim 117 or 118, characterized in that The mixing assembly (549) is arranged in a mixer socket (548) of the transfer housing (547) and comprises a spiral mixing element (552) followed on its outlet side by a vortex chamber (556) with the spray outlet (557).

123. The dispensing device according to claim 122, characterized in that The end of the mixing assembly (549) on the outlet side thereof forms the bottom wall of the vortex chamber (556), and the bottom wall is opposite to the spray outlet (557) of the vortex chamber.

124. Dispensing device according to any one of claims 118 to 123, characterized in that The fastening areas (509) of both the dispensing device (502) and the transfer housing (507; 547) are configured for attaching or removing the mixing and spraying head (503, 555) without relative rotational movement.

125. The dispensing device according to claim 124, characterized in that The fastening area of ​​the transfer housing (507, 547) is deformable.

126. The dispensing device according to claim 123 or 124, characterized in that The fastening region of the dispensing device has snap-on noses (517, 518) which engage in recesses (519, 520) formed in the transfer housing.

127. Dispensing device according to any one of claims 117 to 126, characterized in that The closing part (559) of the mixing and spraying part (561) is provided with a compressed air inlet (560).

128. An applicator (1100) for nasal decolonization using a fluid (F), the applicator comprising: An application tip (1019) suitable for insertion into a nasal cavity, the application tip (1019) being configured to store and release the fluid (F); and a support member (1101) to which the application tip (1019) is connected, wherein the application tip (1019) is formed from at least one of the following: open-cell foam, plastic, flocking, cotton, polyester, rayon, calcium alginate, foam, knitted polyester, medical-grade plastic, thermoplastic elastomer, low-density polyethylene (LDPE), acrylonitrile butadiene styrene (ABS), polypropylene (PP), polyethylene (PE), high-density polyethylene (HDPE), polycarbonate (PC), polyurethane (PU), polyetheretherketone (PEEK) and polyvinyl alcohol (PVA), wherein the applicator (1100) is filled with the fluid (F), and wherein the fluid (F) is a medical fluid, in particular a medical fluid comprising lipid nanoparticles.

129. The applicator (1100) of claim 128, wherein The end (1102) of the application tip (1019) at least partially has at least one of the following shapes: a conical outer shape, an at least substantially conical outer shape, a truncated cone shape, an at least substantially truncated cone shape, a circular shape, an at least substantially circular shape, a spherical shape, an at least substantially spherical shape, an oval shape, an at least substantially oval shape, a rounded edge and a combination of the foregoing, i.e., a shape that increases in size between the end (1102) and the middle part of the application tip (1019).

130. The applicator (1100) of claim 129 or claim 130, wherein The applicator (1100) is a 2K applicator (1100), wherein the application tip (1019) is formed from a first material and the support (1101) is formed from a second material.

131. The applicator (1100) of any one of claims 128 to 130, wherein The application tip (1019) is formed from high-density polyethylene, optionally wherein the high-density polyethylene is sintered and has a porous volume selected in the range of 40% to 60%, preferably in the range of 45% to 55%, wherein the pore size range is in the range of 80μm to 300μm, in particular in the range of 100μm to 250μm.

132. The applicator (1100) of any one of claims 128 to 131, wherein The application tip (1019) has a 10 mm 2 Up to 30mm 2 In the range, especially in the range of 15mm 2 Up to 26mm 2 The surface absorptivity is selected within the range.

133. The applicator (1100) of any one of claims 128 to 132, further comprising a container filled with a liquid, wherein The application tip (1019) is configured to be wetted with liquid stored in the container, preferably, the container is configured to store between 0.2 ml and 10 ml of fluid.

134. The applicator (1100) of any one of claims 128 to 133, wherein The application tip (1019) has an average value of the Young's modulus selected in the range of 0.5 kPa to 500 kPa, preferably in the range of 1 kPa to 300 kPa, in particular in the range of 5 kPa to 250 kPa; and / or wherein the material hardness of the application tip is selected in the range of 25 to 95, in particular in the range of 40 to 60, measured according to the Shore hardness scale A; and / or Therein, the material hardness of the application tip is selected in the range of 35 to 50, in particular in the range of 40 to 48, in particular in the range of 44 to 46, measured according to the Shore hardness scale D, for example of LDPE.

135. The applicator (1100) of any one of claims 128 to 134, wherein The application tip (1019) includes a range of from 30 kg / m 3 Up to 150kg / m 3 The foam has a density of 1000 nm and a porosity in the range of 60 ppi to 150 ppi.

136. The applicator (1100) of any one of claims 128 to 135, wherein At least a portion of the application tip (1019) has an ethanol penetration time in the range of 10 s to 200 s and a maximum diameter of 50 μm or greater within a cross-section of 1.0 mm x 1.0 mm.

137. The applicator (1100) of claim 136, wherein The application tip (1019) comprises a polyurethane elastic body containing 20 or more pores of 300 μm or less.

138. The applicator (1100) of any one of claims 128 to 137, further comprising a dispenser (1010, 1060, 1120), wherein The support member (1101) is a rod comprising a passage (1003), and the passage (1003) is connected to the outlet of the dispenser or is formed integrally with the outlet of the dispenser for dispensing liquid from the container of the dispenser to the application tip (1019) so as to supply the fluid to the application tip (1019).

139. The applicator (1100) of claim 138, wherein The dispenser (1010) comprises: a housing (1011) defining a longitudinal axis (1013) and having a proximal end and a distal end; a discharge device (1015) at least partially arranged inside the housing (1011) and having an inlet opening (1017) located inside the housing (1011) and an application tip (1019), the discharge device (1015) further defining a discharge passage for the fluid (F) extending between the inlet opening (1017) and the application tip (1019); a bracket (1021) received in the proximal region of the housing and extending along the discharge path between a starting position and a final discharge position. The longitudinal axis (1013) is movable relative to the housing (1011), and wherein the bracket (1021) defines a receiving space (1023) suitable for loading a separate container (1025) containing a certain amount of fluid (F) to be discharged; and an activation device (1029) for establishing a flow connection for the fluid from the receiving space of the bracket (1021) to the inlet opening (1017) of the discharge device (1015), wherein the activation device (1029) is suitable for establishing the flow connection when the bracket (1021) is in the final discharge position or moving towards the final discharge position.

140. The applicator (1100) of claim 139, wherein In the starting position, the bracket (1021) protrudes from the proximal end of the housing so as to be pushable by a user further into the housing and toward the final discharge position, and / or wherein the activation device is inoperative when the bracket is in the starting position.

141. The applicator (1100) of any one of claims 139 or 140, wherein The flow connection is established by moving the carriage (1021) towards the final discharge position and / or automatically before the carriage (1021) reaches the final discharge position.

142. The applicator (1100) of any one of claims 128 to 141, wherein The dispenser is a syringe.

143. The applicator (1100) of claim 142, wherein The syringe comprises a plunger and a barrel in which the fluid can be stored, wherein the plunger acts on the fluid during dispensing of the fluid from the barrel via the application tip (1019).

144. The applicator (1100) of any one of claims 128 to 143, wherein The dispenser is an applicator device (1120) comprising: a carrier body (1122) provided with the application tip (1019) at one end and with a pin (1126) at an opposite end; a transverse channel (1134) penetrating the pin (1126); an axial channel (1144) branching off from the transverse channel (1134) and leading to the applicator device (1120); and a reservoir device (1136) having an annular edge seal (1146) sealingly engaging the pin (1126), whereby the reservoir device (1136) is opened by allowing the reservoir device (1136) to be opened. The pin (1126) is shifted toward the application device (1120) to open a flow connection between the reservoir device (1136) and the transverse channel (1134) to activate the applicator device (1120), and the reservoir device (1136) has a receptacle segment that is elastically deformable in at least multiple parts, so that when the applicator device (1120) is activated and there is a flow connection between the transverse channel (1134) and the receptacle segment, the fluid is discharged through the application tip (1019) by manually compressing the elastically deformable area (1154) of the receptacle segment.

145. The applicator (1100) of any one of claims 128 to 144, wherein The rod is a solid rod, and the solid rod is connected to the handle (1082) of the applicator (1100).

146. The applicator (1100) of claim 145, further comprising a container (1080) optionally filled with the fluid (F), wherein the application tip (1019) is stored in the container (1080) and optionally in the fluid (F) prior to use of the application tip (1019).

147. The applicator (1100) of claim 146, further comprising a handle, wherein the handle (1082) is optionally part of a closure (1084) for the container (1080), and the application tip (1019) and the rod are insertable into or removable from the container (1080).

148. The applicator (1100) of claim 147, wherein The handle (1082) is releasably screwed to the container (1080).

149. The applicator (1100) of claim 148, wherein The handle (1082) is part of the support (1101).

150. The applicator (1100) of any one of claims 146 to 149, wherein The container (1080) comprises a membrane (1108), wherein the fluid (F) is stored directly adjacent to the membrane (1108) and the application tip (1019) is stored at the other side of the membrane (1108).

151. The applicator (1100) of any one of claims 146 to 150, wherein The support member (1101) includes one or more seals (1100) configured to seal against an inner surface (1102; 1104) of the container (1080; 1094).

152. The applicator (1100) of any one of claims 146 to 151, wherein The container (1080) is a multi-part container (1080) having an inner container (1094) disposed within an outer container (1096).

153. The applicator (1100) of any one of claims 128 to 152, wherein The fluid (F) is stored in the applicator (1100) and includes at least one of the following substances: medical fluid, dental fluid, veterinary fluid, antiseptic substance, antihistamine, glucocorticoid, epinephrine (adrenal hormone), mast cell stabilizer, anti-leukotriene agent, povidone iodine (PVP-I), mupirocin, alcohol, jojoba oil, water, orange oil, lauric acid, benzalkonium chloride, vitamin E, hypothiocyanate, lactoferrin, N-chlorotaurine, interferon-α, povidone iodine, quaternary ammonium compound, alcohol-based nasal antiseptic, hydroxychloroquine, golden lily flower, loofah with cap, Veratrum sachalinensis and combinations thereof.

154. An emitter, in particular an emitter according to any one of the preceding aspects, wherein The emitter is configured to apply a fluid (F) to a nasal cavity of a patient, wherein the emitter is filled with the fluid (F), wherein the fluid comprises lipid nanoparticles.

155. The ejector of claim 154, wherein The ejector (1200) is formed from at least two parts, an outer housing part (1202) and an inner housing part (1204).

156. An emitter according to claim 154 or claim 155, wherein The inner housing member (1204) has a base (1206) at a first end (1208) thereof.

157. An emitter according to any one of claims 154 to 156, wherein The inner housing member (1204) further includes a pin (1210) at a second end (1212) thereof.

158. The ejector according to claims 156 and 157, wherein The first and second ends (1208, 1212) of the inner housing member (204) are disposed opposite each other.

159. The ejector of claims 154 to 158, wherein The outer housing member (1202) includes a gripping plate (1214) at a first end (1216) thereof.

160. The ejector of claims 154 to 159, wherein The outer housing member (1202) includes a gripping plate (1214) at a first end (1216) thereof.

161. The ejector of claims 154 to 160, wherein The outer housing member (1202) further includes an outlet opening (1218) at a second end (1220) thereof.

162. The ejector according to claim 160 and claim 161, wherein The first and second ends (1214, 1220) of the outer shell component (1202) are disposed opposite each other.

163. The ejector of claims 154 to 162, wherein The outer housing member (1202) further includes a guide passage (1222).

164. The ejector of claim 163 and claim 157, wherein The pin (1210) is guided in the guide passage (1222).

165. The ejector of claim 163 or claim 164, wherein The guide path (1222) includes two or more members selected from the group consisting of: a storage portion (1246), and also includes a first branch (1248), a second branch (1250), a third branch (1252), a fourth branch (1254), a receptacle (1256), a fifth branch (1258), an end stop (1260) and combinations of the foregoing.

166. The emitter of claims 154 to 165, further comprising a child-resistant element.

167. The ejector according to claim 166 and claim 163, wherein The child-resistant element is formed in the guide passage (1222).

168. The ejector of claims 161 to 167, wherein The outlet opening (1218) is formed by an insert (1270), such as a plastic insert 1270.

169. The ejector of claim 168, wherein The plastic insert is fixedly connected to the outer shell component (1202) by a fixed connection, such as a snap-fit ​​connection, a press-fit connection, an adhesively bonded connection, an ultrasonic weld, and / or a laser weld (1266).

170. The ejector according to any one of claims 154 to 169, further comprising a passage (1230) for directing the fluid (F) within the ejector (1200).

171. The ejector of claim 170, wherein The passageway (1230) may be either integrally formed with the outer housing member 1202 or may be formed separately therefrom.

172. An ejector according to claim 170 or claim 171 when dependent on claim 168 or claim 169, wherein The insert (1270) further comprises a sealing surface (1262) that seals against an outer wall (1272) of the passageway (1230).

173. An emitter according to any one of claims 170 to 172, wherein The passageway (1230) is formed in the metal insert (1268).

174. The ejector of claim 173, wherein The metal insert (1268) is journaled at the second end (1220) via a sealing surface (1262) and is journaled at the first end (1216) of the outer shell component (1202) via a further sealing surface (1264).

175. The emitter according to any one of claims 154 to 174, further comprising a piercing tip (1224).

176. An ejector according to claim 175, when dependent on any one of claims 170 to 174, wherein The puncture tip (1224) is connected to the passageway (1230).

177. The ejector of claim 175 or claim 176, wherein The piercing tip is injection molded around the metal insert (1268).

178. Use of a drain according to one or more of the preceding claims, said drain being configured to apply a fluid (F) to the nasal cavity of a patient, wherein The emitter is filled with a fluid (F), wherein the fluid comprises lipid nanoparticles, and the fluid is applied at and / or in the nasal cavity.

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