Tableted candy with hangover alleviating function and preparation method thereof

Abstract

The invention relates to the technical field of functional foods, in particular to tabletted candies with an anti-alcohol function and a preparation method of the tabletted candies. The tablet candy with the hangover alleviating function comprises the following components in percentage by weight: 10%-30% of a radix puerariae extract, 5%-15% of curcumin nano-liposome, 3%-8% of L-cysteine, 2%-5% of vitamin B and the balance of auxiliary materials, and the auxiliary materials comprise the following components in percentage by weight: 10%-30% of a radix puerariae extract, 5%-15% of curcumin nano-liposome, 3%-8% of L-cysteine, 2%-5% of vitamin B and the balance of auxiliary materials. The radix puerariae extract is used for inhibiting alcohol absorption, curcumin is used for resisting inflammation and protecting liver, L-cysteine is used for accelerating acetaldehyde decomposition to form a triple hangover alleviating mechanism, and liver injury is effectively reduced; by compounding the sorbitol and the peppermint essence, the bitter taste of the active ingredients is covered, and the palatability is strong.

Description

Technical Field

[0001] The invention relates to the technical field of functional foods, and in particular to a compressed candy with a hangover-relieving function and a preparation method thereof. Background Art

[0002] Alcohol, as a food, has a rich history. Chinese drinking culture permeates the history of the country. According to foreign media reports, China is ranked the second most alcoholic nation in the world. When people drink alcohol, it is absorbed into the bloodstream through the gastrointestinal tract. The body's ability to detoxify alcohol relies on various enzymes in the liver, which break down alcohol into non-toxic acetic acid, which then decomposes into water and carbon dioxide.

[0003] Alcohol has dual effects. Small amounts of alcohol can have a positive impact on health and mood, quenching thirst, promoting blood circulation and removing blood stasis, moistening the intestines and promoting bowel movements, and alleviating anxiety. However, excessive drinking can easily cause vomiting, dizziness, and headaches, seriously impacting the drinker's health. Long-term excessive drinking can not only damage the spleen, stomach, and especially the liver, but can also lead to cirrhosis and other organ diseases. Therefore, the development of alcohol detoxification products is of great significance.

[0004] In the prior art, although there are many types of alcohol-relieving and liver-protecting health food products with varying functional effects, there is still much room for improvement. For example, drinks with alcohol-relieving effects generally have the good effects of clearing heat and reducing internal heat, protecting and nourishing the liver, but they generally have many medicinal flavors, complex interactions, and are inconvenient to carry. To facilitate portability and consumption, many alcohol-relieving and liver-protecting products are processed into soft candies. However, since the ingredients that have the liver-protecting effect in existing alcohol-relieving and liver-protecting soft candies are mostly plant extracts, the addition of these ingredients often makes the soft candies more prone to sanding and melting, thereby reducing the quality of the soft candies and affecting their normal sales and consumption. In addition, in order to improve their taste and quality, many additives are often added, which can also have adverse effects on the human body to a certain extent. In order to reduce the addition of additives, while accurately controlling the amount of drug added, and with low cost and good effect, compressed candies have become the best choice. Currently, there are many compressed tablet products, but the existing alcohol-relieving compressed tablet products are relatively few. Moreover, compressed tablet products generally contain many functional ingredients with mediocre actual effects. The complex ingredients can easily cause a burden on the body after long-term use, increasing the cost. Therefore, there is an urgent need to provide a candy that can relieve alcohol consumption and protect the liver. Summary of the Invention

[0005] The purpose of the present invention is to solve at least one of the technical problems existing in the prior art and to provide a compressed candy with a hangover-relieving function and a preparation method thereof.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows: a compressed candy with a hangover-relieving function, comprising kudzu root extract, curcumin nanoliposomes, L-cysteine, B vitamins, and auxiliary materials, wherein the kudzu root extract accounts for 10-30%, the curcumin nanoliposomes account for 5-15%, the L-cysteine ​​accounts for 3-8%, and the B vitamins account for 2-5%.

[0007] Furthermore, the auxiliary materials include one or more of sweeteners, lubricants, and flavors.

[0008] Furthermore, the sweetener is sorbitol, the lubricant is magnesium stearate, and the flavor is mint.

[0009] Furthermore, the proportion of sorbitol is 30-50%; the proportion of magnesium stearate is 0.5-1%; and the proportion of mint is 0.1-0.3%.

[0010] Furthermore, the B vitamins include one or more of B1, B6, and B12.

[0011] Furthermore, the average particle size of the curcumin nanoliposomes is 80-150 nm.

[0012] A method for preparing a compressed candy with a hangover-relieving function comprises the following steps:

[0013] S1. Pretreatment: prepare kudzu root extract, curcumin nanoliposomes, L-cysteine, B vitamins and excipients and weigh them;

[0014] S2. Mixing: Mixing the kudzu root extract, curcumin nanoliposomes, L-cysteine, vitamin B complex, and excipients in equal and increasing amounts step by step, while controlling the humidity to less than 30%, to obtain a mixture;

[0015] S3, granulation: the mixed mixture is wet granulated with a binder, wherein the binder is 5% polyvinylpyrrolidone ethanol solution;

[0016] S4. Tabletting: The granulated mixture is placed in a rotary tablet press for tabletting and sterilized to obtain a compressed candy. The pressure during the tabletting process is 10-15 kN, and the tablet weight of the compressed candy is 1.0-1.5 g.

[0017] Furthermore, the preparation of the kudzu root extract includes placing the washed kudzu root in a crushing barrel for crushing, extracting kudzu root flavonoids from the kudzu root by countercurrent extraction after the crushing is completed, then hydrolyzing the kudzu root flavonoid extract with 4-6% hydrochloric acid for 3-6 hours, and then extracting with ethyl acetate and leaving it to precipitate puerarin, washing the ethyl acetate phase with water, concentrating, recrystallizing, drying, grinding, and passing through an 80-mesh sieve to obtain the kudzu root extract.

[0018] Furthermore, curcumin nanoliposomes are obtained by spray drying protein lecithin, cholesterol and curcumin.

[0019] Furthermore, the method further comprises coating: coating the compressed candies with a hydroxypropyl methylcellulose film.

[0020] Compared with the existing technology, the technical solution of this application has the following beneficial effects:

[0021] 1. The present application discloses a compressed candy with a hangover-relieving function, comprising kudzu root extract, curcumin nanoliposomes, L-cysteine, B vitamins, and excipients, wherein the kudzu root extract accounts for 10-30%, the curcumin nanoliposomes account for 5-15%, the L-cysteine ​​accounts for 3-8%, and the B vitamins account for 2-5%. The candy achieves a triple hangover-relieving mechanism by utilizing kudzu root extract to inhibit alcohol absorption, curcumin to fight inflammation and protect the liver, and L-cysteine ​​to accelerate the decomposition of acetaldehyde, thereby effectively reducing liver damage. The candy is compounded with sorbitol and mint essence to mask the bitterness of the active ingredients and has strong palatability.

[0022] 2. The compressed candy of the present application has a good taste and is easy to carry. The candy can accelerate the decomposition of alcohol and relieve symptoms after drinking, such as headaches and nausea, through the compounding of natural active ingredients. Animal experiments have shown that it can reduce blood alcohol concentration by 20%-35% within 30 minutes and reduce liver damage. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 The present invention is a flow chart of a method for preparing a compressed candy with a hangover-relieving function according to a preferred embodiment of the present invention. DETAILED DESCRIPTION

[0024] The technical solutions of the present invention will be described clearly and completely below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0025] A preferred embodiment of the present invention is a compressed candy with a hangover-relieving function, comprising kudzu root extract, curcumin nanoliposomes, L-cysteine, B vitamins, and excipients, wherein the kudzu root extract accounts for 10%, the curcumin nanoliposomes account for 5%, the L-cysteine ​​accounts for 3%, and the B vitamins account for 2%; wherein the excipients include one or more of a sweetener, a lubricant, and a flavor; the sweetener is sorbitol, the lubricant is magnesium stearate, and the flavor is mint; the sorbitol accounts for 30%; the magnesium stearate accounts for 0.5%; the mint accounts for 0.1%; the B vitamins include B1, B6, and B12; the average particle size of the curcumin nanoliposomes is 80-150 nm, realizing a triple hangover-relieving mechanism by utilizing kudzu root extract to inhibit alcohol absorption, curcumin to fight inflammation and protect the liver, and L-cysteine ​​to accelerate the decomposition of acetaldehyde, thereby effectively reducing liver damage; sorbitol is compounded with mint flavor to mask the bitterness of the active ingredient and enhance palatability.

[0026] Reference Figure 1 As shown, a method for preparing a compressed candy with a hangover-relieving function comprises the following steps:

[0027] S1. Pretreatment: prepare kudzu root extract, curcumin nanoliposomes, L-cysteine, B vitamins and excipients and weigh them;

[0028] The preparation of the kudzu root extract comprises placing the washed kudzu root in a crushing barrel for crushing, extracting kudzu root flavonoids from the kudzu root by countercurrent extraction after the crushing is completed, then hydrolyzing the kudzu root flavonoid extract with 4-6% hydrochloric acid for 3-6 hours, extracting with ethyl acetate and allowing to precipitate puerarin, washing the ethyl acetate phase with water, concentrating, recrystallizing, drying, grinding, and passing through an 80-mesh sieve to obtain the kudzu root extract;

[0029] Curcumin nanoliposomes are obtained by spray drying protein lecithin, cholesterol and curcumin. Specifically, a certain amount of phospholipids, cholesterol and curcumin are weighed and completely dissolved in anhydrous ethanol at 50°C. The dissolved solution is evaporated on a rotary evaporator to remove the anhydrous ethanol to form a uniform film. A certain amount of deionized water is added to the film for hydration to form a coarse liposome suspension. The coarse liposome suspension is treated using dynamic high-pressure microfluidization (DHPM) technology to reduce particle size and improve stability. The obtained liposomes are subjected to quality control tests such as particle size, encapsulation efficiency and morphology. This curcumin nanoliposome technology solves the problem of poor water solubility of curcumin and improves bioavailability by more than 30%.

[0030] S2. Mixing: Mixing the kudzu root extract, curcumin nanoliposomes, L-cysteine, vitamin B complex, and excipients in equal and increasing amounts step by step, while controlling the humidity to less than 30%, to obtain a mixture;

[0031] S3, granulation: the mixed mixture is wet granulated with a binder, wherein the binder is 5% polyvinylpyrrolidone ethanol solution;

[0032] S4. Tabletting: The granulated mixture is placed in a rotary tablet press for tabletting and sterilized to obtain a compressed candy. The pressure during the tabletting process is 10-15 kN, and the tablet weight of the compressed candy is 1.0-1.5 g.

[0033] S5. Coating: Coat the compressed candies with a hydroxypropyl methylcellulose film to prevent moisture and increase stability. After tableting, the pH value of the finished tablets is 6.5-7.0, and the disintegration time of the tablets is ≤3 minutes (meeting the requirements for oral rapid dissolution).

[0034] Example 2

[0035] The difference between this embodiment and embodiment 1 is that the proportion of the kudzu root extract is 20%, the proportion of curcumin nanoliposomes is 10%, the proportion of L-cysteine ​​is 6%, the proportion of B vitamins is 3%, the proportion of sorbitol is 40%, the proportion of magnesium stearate is 0.8%, and the proportion of mint is 0.2%.

[0036] Example 3

[0037] The difference between this embodiment and embodiment 1 is that: the proportion of kudzu root extract is 30%, the proportion of curcumin nanoliposomes is 15%, the proportion of L-cysteine ​​is 8%, the proportion of B vitamins is 5%, the proportion of sorbitol is 50%, the proportion of magnesium stearate is 1%, and the proportion of mint is 0.3%.

[0038] Performance Testing

[0039] After the rats were gavaged with alcohol, they were given the products of Examples 1-3 of the present application.

[0040] Example 1: Blood alcohol concentration decreased by 38% within 60 minutes, and ALT / AST (liver damage indicators) decreased by 45%;

[0041] Example 2 Blood alcohol concentration dropped by 42% within 60 minutes, and ALT / AST (liver damage index) decreased by 50%.

[0042] Example 3 Blood alcohol concentration dropped by 33% within 60 minutes, and ALT / AST (liver damage index) decreased by 53%.

[0043] Under the premise that no conflict occurs, those skilled in the art may freely combine and superimpose the above-mentioned additional technical features.

[0044] It will be understood that the present invention is described by way of some embodiments, and it will be appreciated by those skilled in the art that various changes or equivalent substitutions may be made to these features and embodiments without departing from the spirit and scope of the present invention. In addition, under the teachings of the present invention, these features and embodiments may be modified to adapt to specific circumstances and materials without departing from the spirit and scope of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed herein, and all embodiments falling within the scope of the claims of this application are intended to be protected by the present invention.

Claims

1. A compressed candy with the function of sobering up, characterized in that: The invention comprises kudzu root extract, curcumin nanoliposomes, L-cysteine, vitamin B group and auxiliary materials, wherein the kudzu root extract accounts for 10-30%, the curcumin nanoliposomes accounts for 5-15%, the L-cysteine ​​accounts for 3-8%, and the vitamin B group accounts for 2-5%.

2. The compressed candy with hangover sobering function according to claim 1, characterized in that: The auxiliary materials include one or more of sweeteners, lubricants and flavors.

3. The compressed candy with hangover sobering function according to claim 2, characterized in that: The sweetener is sorbitol, the lubricant is magnesium stearate, and the flavor is mint.

4. The compressed candy with hangover sobering function according to claim 3, characterized in that: The proportion of the sorbitol is 30-50%; the proportion of the magnesium stearate is 0.5-1%; and the proportion of the mint is 0.1-0.3%.

5. The compressed candy with hangover sobering function according to claim 1, characterized in that: The B vitamins include one or more of B1, B6, and B12.

6. The compressed candy with hangover sobering function according to claim 1, characterized in that: The average particle size of the curcumin nanoliposomes is 80-150 nm.

7. A method for preparing a compressed candy with a hangover-relieving function, characterized in that: The following steps are involved: S1. Pretreatment: prepare kudzu root extract, curcumin nanoliposomes, L-cysteine, B vitamins and excipients and weigh them; S2. Mixing: Mixing the kudzu root extract, curcumin nanoliposomes, L-cysteine, vitamin B complex, and excipients in equal and increasing amounts step by step, while controlling the humidity to less than 30%, to obtain a mixture; S3, granulation: the mixed mixture is wet granulated with a binder, wherein the binder is 5% polyvinylpyrrolidone ethanol solution; S4. Tabletting: The granulated mixture is placed in a rotary tablet press for tabletting and sterilized to obtain a compressed candy. The pressure during the tabletting process is 10-15 kN, and the tablet weight of the compressed candy is 1.0-1.5 g.

8. The method for preparing the compressed candy with hangover-relieving function according to claim 7, characterized in that: The preparation of the kudzu root extract comprises placing the washed kudzu root in a crushing barrel for crushing, extracting kudzu root flavonoids from the kudzu root by countercurrent extraction after the crushing is completed, then hydrolyzing the kudzu root flavonoids extract by using 4-6% hydrochloric acid for 3-6 hours, extracting with ethyl acetate and allowing to precipitate puerarin, washing the ethyl acetate phase with water, concentrating, recrystallizing, drying, grinding, and passing through an 80-mesh sieve to obtain the kudzu root extract.

9. The method for preparing the compressed candy with hangover-relieving function according to claim 7, characterized in that: The curcumin nanoliposome is obtained by spray drying protein lecithin, cholesterol and curcumin.

10. The method for preparing the compressed candy with hangover-relieving function according to claim 7, characterized in that: The method also includes coating: coating the compressed candy with a hydroxypropyl methylcellulose film.

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