Application of bovine JunD gene copy number variation as molecular marker in yak molecular breeding

By detecting the copy number variation of the yak JunD gene and using real-time quantitative PCR technology and association analysis, the problem of long traditional breeding cycle was solved, early selection and efficient breeding were achieved, and the selection accuracy and breeding efficiency of yak growth traits were improved.

CN120666044APending Publication Date: 2025-09-19NORTHWEST A & F UNIV
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Patent Information

Application Number
CN202510910885.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-02
Publication Date
2025-09-19

AI Technical Summary

Technical Problem

The existing technology lacks research on copy number variation of the bovine JunD gene, resulting in bottlenecks in yak molecular breeding such as long traditional breeding cycles and delayed phenotypic determination, making it impossible to achieve early selection and efficient breeding.

Method used

Real-time quantitative PCR was used to detect copy number variation of the yak JunD gene. Specific primers were designed to amplify fragments of the JunD gene and the internal reference gene BTF3. The 2×2-ΔΔCt method was used to determine the copy number type of each individual. Combined with association analysis, the copy number type with advantageous growth traits was screened out.

Benefits of technology

It has achieved advanced selection of growth traits in the early stages of yak birth or even in the embryonic stage, significantly shortening the breeding cycle, improving breeding efficiency, ensuring the reliability and stability of selection results, and meeting the market demand for high-quality yak beef.

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Abstract

The invention provides application of cattle JunD gene copy number variation as a molecular marker in yak molecular breeding, belongs to the technical field of livestock molecular genetics research, and establishes association between the yak JunD gene copy number variation and growth traits based on physiological action of the yak JunD gene and a CNV regulation mechanism. The method is beneficial for accelerating molecular marker-assisted selective breeding of yaks, so that an excellent yak population is established, and the method has the characteristics of simplicity, rapidness and convenience in popularization and application.
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Citation Information

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