Dispersible oil suspending agent containing spirotetramat and thiocyclam and application thereof

Abstract

The invention belongs to the field of pesticides, and particularly relates to a dispersible oil suspending agent containing spirotetramat and thiocyclam and application of the dispersible oil suspending agent, and the dispersible oil suspending agent comprises the following components in percentage by weight: 5-15% of spirotetramat, 20-30% of thiocyclam, 10-15% of an emulsifier, 2-8% of a wetting dispersant, 1-5% of ethylene glycol, 0.1-1% of a defoaming agent SAF, 0.1-1% of organic bentonite and the balance of methyl oleate. The dispersible oil suspending agent prepared by the invention has excellent suspension rate and low foamability; the bactericidal composition has excellent prevention and treatment effects on crop pests, can effectively reduce the use dosage of active components, and reduces environmental pollution.

Description

Technical Field

[0001] The invention belongs to the field of pesticides and relates to a dispersible oil suspension containing spirotetramat and cyclopentadienyl and an application thereof. Background Art

[0002] Chemical pesticides face challenges such as long R&D cycles and high costs. It's estimated that companies need to screen at least 100,000 compounds to find a new, commercially acceptable synthetic pesticide. The right pesticide formulation can extend its lifespan. Therefore, the R&D and optimization of pesticide formulations have received significant attention from both the government and researchers in recent years.

[0003] Dispersible oil suspension concentrates (DSCs) are highly dispersed and stable suspensions of one or more solid pesticide active ingredients in a non-aqueous dispersion medium, typically diluted with water. They offer two key advantages: First, the use of a dispersion medium such as vegetable oil or mineral oil makes them safe and environmentally friendly; second, they protect the active ingredients, reduce droplet drift, and enhance droplet adhesion, penetration, and wetting and spreading on crop surfaces. Ultimately, these enhance the pesticide's effectiveness and improve its utilization rate.

[0004] Spirotetramat is a systemic, bidirectionally active compound. It inhibits the activity of acetyl-CoA carboxylase, a enzyme involved in fat synthesis in insects, thereby inhibiting fat synthesis and disrupting normal energy metabolism, ultimately leading to death. It is highly effective against pests such as whiteflies and thrips. Cyclodex is a neristoxin-based insecticide with contact and stomach toxicity, some systemic activity, and egg-killing properties. It can be used to control a variety of pests, including thrips. Patent application CN201210039591 discloses an insecticide composition containing spirotetramat and neristoxins. The composition comprises active ingredients A and B, with the remainder being adjuvants. Active ingredient A is spirotetramat, and active ingredient B is any of dimehypo, dimehypo, and cyclodex, with a weight ratio of 1:80 to 80:1. The composition can be formulated as a wettable powder, water-dispersible granules, suspension concentrate, suspoemulsion, emulsion in water, or microemulsion.

[0005] There is no report in the existing literature on the preparation of a dispersible oil suspension concentrate by combining spirotetramat and thiocarb. Summary of the Invention

[0006] The present invention aims to provide a dispersible oil suspension containing spirotetramat and cyclopenta ...

[0007] A dispersible oil suspension containing spirotetramat and cyclopentane, comprising the following ingredients in percentage by weight: 5-15% spirotetramat, 20-30% cyclopentane, 10-15% emulsifier, 2-8% wetting and dispersing agent, 1-5% ethylene glycol, 0.1-1% defoaming agent SAF, 0.1-1% organic bentonite, and methyl oleate making up to 100%;

[0008] Preferably, the emulsifier is a combination of TERGITOL ECO-36 and Termul 5030; and the wetting and dispersing agent is a combination of Dispersogen 1494 and Morwet D-390.

[0009] Preferably, the mass ratio of TERGITOL ECO-36 to Termul 5030 in the emulsifier is 1-5:1-5; the mass ratio of Dispersogen 1494 to Morwet D-390 in the wetting and dispersing agent is 1-5:1-5.

[0010] The present invention provides a dispersible oil suspension containing spirotetramat and cyclopentane. The dispersible oil suspension contains the following components in percentage by weight: 10% spirotetramat, 25% cyclopentane, 12% emulsifier, 6% wetting and dispersing agent, 3% ethylene glycol, 0.5% defoaming agent SAF, 0.5% organic bentonite, and methyl oleate making up 100%.

[0011] Preferably, the dispersible oil suspension comprises the following ingredients in percentage by weight: 10% spirotetramat, 25% cyclohexane, 6% TERGITOL ECO-36, 6% Termul 5030, 4% Dispersogen 1494, 2% Morwet D-390, 3% ethylene glycol, 0.5% defoamer SAF, 0.5% organobentonite, and methyl oleate to make up 100%.

[0012] The dispersible oil suspension concentrate of the present invention is used for preventing and controlling crop pests. Preferably, the pests are whiteflies or thrips.

[0013] Compared with the prior art, the present invention achieves the following beneficial technical effects:

[0014] The dispersible oil suspension concentrate of the present invention comprises a combination of TERGITOL ECO-36 and Termul 5030 as the emulsifier and a combination of Dispersogen 1494 and Morwet D-390 as the wetting and dispersing agent, which can significantly improve the suspension rate of the dispersible oil suspension concentrate and reduce foaming to a certain extent.

[0015] The dispersible oil suspension prepared by the present invention has excellent control effects on whiteflies and thrips; it is speculated that the reason is that the combination of auxiliary materials improves the adhesion, permeability and wetting and spreading properties of droplets on crop surfaces. DETAILED DESCRIPTION

[0016] Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative work shall fall within the scope of protection of the present invention.

[0017] The present invention will be further explained below with reference to specific embodiments.

[0018] Example 1: Preparation of dispersible oil suspension of spirotetramat and thiocyclam

[0019] The composition is as follows: 10% spirotetramat, 25% cyclopentane, 12% emulsifier, 6% wetting and dispersing agent, 3% ethylene glycol, 0.5% defoamer SAF, 0.5% organic bentonite, and methyl oleate to make up 100%. The specific composition is as follows:

[0020] Table 1: 35% dispersible oil suspension formulation

[0021] Preparation method:

[0022] Mix the oil phase carrier with spirotetramat, thiocyclam, and excipients in appropriate proportions. Shear for 3-5 minutes to form a uniform suspension. Transfer the dispersed suspension to a sand mill and grind with an appropriate amount of zirconium beads. Monitor the particle size during grinding using a laser particle size analyzer. When the particle size distribution D90 is ≤5μm, stop grinding and filter to obtain a 35% spirotetramat and thiocyclam dispersible oil suspension concentrate. Then, perform various technical analysis and testing.

[0023] Quality control indicators:

[0024] Table 2: Quality indexes of 35% dispersible oil suspension concentrate

[0025] Oil suspension concentrates require dilution with water. To ensure rapid emulsification and dispersion of the oil phase components after dilution, a suitable emulsifier is essential. Furthermore, oil suspension concentrates are thermodynamically unstable systems, requiring the addition of a wetting and dispersing agent to maintain the particles in a discrete state. While emulsifiers added to oil suspension concentrates have a certain dispersing effect, they cannot completely replace the role of wetting and dispersing agents. Table 2 shows that different emulsifiers and wetting and dispersing agents significantly affect the suspension efficiency, sustained foaming, and thermal storage stability of the samples prepared. In Formulation 1, the emulsifier combination of TERGITOL ECO-36 and Termul 5030, and the wetting and dispersing agents of Dispersogen 1494 and Morwet D-390 significantly improved the suspension efficiency of the dispersible oil suspension concentrate and reduced foaming to a certain extent.

[0026] Example 2: Efficacy test of 35% dispersible oil suspension against greenhouse tomato whitefly

[0027] Test agents: Preparation 1, Preparation 2, Preparation 4, Preparation 5 in Example 1

[0028] Experimental method: The experiment was conducted in a greenhouse tomato greenhouse. The experiment was divided into two treatments: the treatment with pesticide and the control with water. Each treatment was repeated 3 times. The plot area was 25m2. 2 The tomato plants were arranged in randomized blocks. The upper and lower leaves of the tomatoes were sprayed with each treatment agent using a manual backpack electric sprayer. The control (CK) was sprayed with an equal amount of water. No other agents were applied except the test agent, and no other insecticides were used.

[0029] Survey Methods: Five random sampling sites were selected in each plot, with two plants fixed at each site and marked with signs. The number of adult whiteflies on the underside of marked tomato leaves was counted. The baseline adult population of Bemisia tabaci was determined before pesticide application, and the number of live adults was counted 7 days after application.

[0030] The insect population reduction rate and control effect were calculated according to the following formula:

[0031] Insect population reduction rate = [(insect population before application - insect population after application) / insect population before application] × 100;

[0032] Control effect = [(insect population reduction rate in the treated area - insect population reduction rate in the control area) / (1 - insect population reduction rate in the control area)] × 100.

[0033] Test results

[0034] Table 3: Efficacy of 35% dispersible oil suspension against tomato whitefly

[0035] As shown in Table 3, the 35% dispersible oil suspension prepared in this invention exhibits excellent control efficacy against tomato whiteflies. Formulation 1, in particular, significantly enhances the control efficacy against tomato whiteflies, demonstrating a significant difference compared to the other treatments. This is presumably due to the improved adhesion, penetration, and wetting and spreading properties of the spray droplets on the crop surface.

[0036] Example 3: Efficacy test of 35% dispersible oil suspension against cowpea thrips

[0037] Test method: The test was conducted in a cowpea field. The test was divided into two treatments: the treatment with pesticide and the control with water. Each treatment was repeated 3 times. The plot area was 40m2. 2 Cowpea plants were evenly sprayed with a knapsack electric sprayer until the entire plant was moistened with droplets. The control (CK) was sprayed with an equal amount of water. No other pesticides were applied besides the test pesticide, and no other insecticide treatments were performed.

[0038] Survey Method: A five-point sampling method was used, with two cowpea plants surveyed at each point. Three flowers from the middle and upper parts of each plant were selected to determine the number of thrips within the flowers. The baseline population was determined before application, and the number of live insects was counted 7 days after application. The population reduction rate and control efficacy were calculated.

[0039] The insect population reduction rate and control effect were calculated according to the following formula:

[0040] Insect population reduction rate = (number of live insects before application - number of live insects after application) / number of live insects before application × 100;

[0041] Control effect = (insect population reduction rate of pesticide treatment - insect population reduction rate of blank control) / (1 - insect population reduction rate of blank control) × 100.

[0042] Test results

[0043] Table 4: Efficacy of 35% dispersible oil suspension against cowpea thrips

[0044] As shown in Table 4, the 35% dispersible oil suspension prepared in the present invention exhibited excellent control efficacy against cowpea thrips. In particular, Formulation 1 significantly enhanced the control efficacy against cowpea thrips, demonstrating a significant difference compared to the other treatments. This is presumably due to the improved adhesion, penetration, and wetting and spreading properties of the spray droplets on the crop surface due to the addition of the excipients.

[0045] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same.

Claims

1. A dispersible oil suspension concentrate comprising spirotetramat and cyclopenta ... The composition comprises the following ingredients in percentage by weight: 5-15% spirotetramat, 20-30% cyclopentane, 10-15% emulsifier, 2-8% wetting and dispersing agent, 1-5% ethylene glycol, 0.1-1% defoaming agent SAF, 0.1-1% organic bentonite, and methyl oleate making up to 100%; The emulsifier is a combination of TERGITOL ECO-36 and Termul 5030; The wetting and dispersing agent is a combination of Dispersogen 1494 and Morwet D-390.

2. The dispersible oil suspension according to claim 1, characterized in that The composition comprises the following ingredients in percentage by weight: 10% spirotetramat, 25% cyclohexane, 12% emulsifier, 6% wetting and dispersing agent, 3% ethylene glycol, 0.5% defoaming agent SAF, 0.5% organic bentonite, and methyl oleate making up 100%.

3. The dispersible oil suspension according to claim 1 or 2, characterized in that The mass ratio of TERGITOL ECO-36 and Termul 5030 in the emulsifier is 1-5:1-5; the mass ratio of Dispersogen 1494 and Morwet D-390 in the wetting and dispersing agent is 1-5:1-5.

4. The dispersible oil suspension according to claim 1 or 2, characterized in that The mass ratio of TERGITOL ECO-36 and Termul 5030 in the emulsifier is 1:1; the mass ratio of Dispersogen 1494 and Morwet D-390 in the wetting and dispersing agent is 2:

1.

5. The dispersible oil suspension according to claim 4, characterized in that The product comprises the following ingredients in percentage by weight: 10% spirotetramat, 25% cyclopentane, 6% TERGITOL ECO-36, 6% Termul 5030, 4% Dispersogen 1494, 2% Morwet D-390, 3% ethylene glycol, 0.5% defoamer SAF, 0.5% organic bentonite, and methyl oleate making up to 100%.

6. Use of the dispersible oil suspension concentrate according to any one of claims 1 to 5 for controlling crop pests.

7. The use according to claim 6, characterized in that The pests are whiteflies or thrips.

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