Composition suitable for repairing and relieving skin barrier and preparation method thereof

Abstract

The invention relates to the technical field of skin care products, and particularly discloses a composition suitable for skin barrier repairing and relieving and a preparation method thereof.The composition suitable for skin barrier repairing and relieving is prepared from, by mass, 39.48-46.12 parts of solvent; 28.18 to 32.22 parts of a humectant; 22-24 parts of a composite plant extract; 2.9 to 3.1 parts of a skin conditioner; 0.8-1.2 parts of a preservative; the composite plant extract is prepared by compounding a chenopodium quinoa seed extract, a caulerpa lentillifera extract, a medicago sativa extract and a rhizoma nardostachyos latifolia extract. The method has the advantage that the repairing effect on sensitive skin is further improved.

Description

Technical Field

[0001] The present invention relates to the field of skin care products, and in particular to a composition suitable for repairing and soothing skin barriers and a preparation method thereof. Background Art

[0002] Sensitive skin is easily irritated by environmental factors, seasonal changes and facial care products, resulting in allergies. Sensitive skin repair needs to meet the triple needs of anti-inflammatory, barrier repair and anti-oxidation. Existing skin care products mainly achieve anti-inflammatory, barrier repair, anti-oxidation and other effects by adding chemical synthetic ingredients. However, chemical synthetic ingredients themselves have certain irritation and are easy to cause secondary damage when used on sensitive skin. Therefore, to address the problem of sensitive skin, more and more skin care products using natural ingredients such as plant extracts have become mainstream. However, the effect of existing skin care products on repairing sensitive skin is still relatively general, and it is difficult to achieve the effect of quickly repairing sensitive skin. Therefore, there is still room for improvement. Summary of the Invention

[0003] In order to further improve the repair effect on sensitive skin, the present application provides a composition suitable for skin barrier repair and soothing and a preparation method thereof.

[0004] In a first aspect, the present application provides a composition suitable for repairing and soothing the skin barrier, which adopts the following technical solution: A composition suitable for repairing and soothing the skin barrier, comprising the following components in parts by weight: 39.48-46.12 parts of solvent; 28.18-32.22 parts of moisturizer; 22-24 parts of compound plant extract; 2.9-3.1 parts of skin conditioning agent; 0.8-1.2 parts of preservatives; The composite plant extract is a combination of quinoa seed extract, long-stem grape fern extract, alfalfa extract and spikenard extract.

[0005] By adopting the above technical solution, by using a combination of quinoa seed extract, long-stem grape fern extract, alfalfa extract, and spoon-leaved spikenard extract, with the mutual cooperation of various active ingredients, it can have significant anti-inflammatory, soothing, and free radical scavenging effects. In combination with moisturizers and skin conditioners, it can well promote skin barrier repair, effectively and quickly repair sensitive skin, making sensitive skin less prone to allergies, and can quickly relieve the discomfort caused by skin allergies, thus meeting the needs of consumers well.

[0006] Preferably, in the composite plant extract, the mass ratio of quinoa seed extract, long-stem grape fern extract, alfalfa extract, and spikenard extract is 9.5-10.5:4.8-5.2:4.8-5.2:2.9-3.1.

[0007] By adopting the above technical solution and specifically selecting the mass ratios of quinoa seed extract, long-stem grape fern extract, alfalfa extract, and spikenard extract, the active ingredients can be better combined in a specific ratio, thereby exerting a more significant synergistic effect and a more significant effect on repairing sensitive skin.

[0008] Preferably, the moisturizing agent is a compound of butylene glycol and sodium hyaluronate.

[0009] By adopting the above technical solution, the moisturizing effect of the combination of butanediol and sodium hyaluronate is better, and when combined with the compound plant extract, it can better promote the repair of the skin barrier.

[0010] Preferably, in the moisturizing agent, the mass ratio of butylene glycol to sodium hyaluronate is 28-32:0.18-0.22.

[0011] By adopting the above technical solution and specifically selecting the mass ratio of butylene glycol and sodium hyaluronate, a larger amount of butylene glycol is used, and the moisturizing effect is better. Moreover, under the action of the composite plant extract, the problem of increased viscosity caused by the large amount of butylene glycol can be well alleviated, so that the product experience is better and it can have a more significant moisturizing effect.

[0012] Preferably, the skin conditioning agent is pyridoxine.

[0013] By adopting the above technical solution and specifically selecting pyridoxine, the skin conditioning effect is better.

[0014] Preferably, the preservative is a compound of p-hydroxyacetophenone and 1,2-hexanediol, and the mass ratio of p-hydroxyacetophenone to 1,2-hexanediol is 0.4-0.6:0.4-0.6.

[0015] By adopting the above technical solution and specifically selecting the combination of p-hydroxyacetophenone and 1,2-hexanediol, the antiseptic effect is better and the irritation is lower, making it more suitable for sensitive skin.

[0016] Preferably, the solvent is deionized water.

[0017] By adopting the above technical solution and specifically selecting deionized water, the various ingredients in the composition suitable for skin barrier repair and soothing can be fully dissolved in the solvent, thereby better exerting synergistic effects and achieving better results in repairing sensitive skin.

[0018] In a second aspect, the present application provides a method for preparing a composition suitable for skin barrier repair and soothing, using the following technical solution: A method for preparing the above-mentioned composition suitable for repairing and soothing the skin barrier comprises the following steps: Step 1), mixing the solvent and the moisturizer at 80-85° C. to obtain a premix; Step 2) The premix is ​​cooled to 35-40° C., and then the composite plant extract, skin conditioner, and preservative are added to the premix and mixed evenly to obtain a composition suitable for skin barrier repair and soothing.

[0019] By adopting the above technical solution, the composition suitable for skin barrier repair and soothing has significant anti-inflammatory, soothing, free radical scavenging, skin barrier repair and other effects. It can quickly repair sensitive skin, making sensitive skin less prone to allergies, and can quickly relieve the discomfort caused by allergies, thus meeting the needs of consumers well.

[0020] In summary, this application has the following beneficial effects: 1. Since the present application adopts a compound of quinoa seed extract, long-stem grape fern extract, alfalfa extract, and spoon-leaved spikenard extract, with the mutual cooperation of various active ingredients, it can have significant anti-inflammatory, soothing, and free radical scavenging effects. In combination with moisturizers and skin conditioners, it can well promote skin barrier repair, effectively and quickly repair sensitive skin, making sensitive skin less prone to allergies, and can quickly relieve the discomfort caused by skin allergies, thus meeting the needs of consumers well.

[0021] 2. In this application, it is preferred to specifically select the mass ratio of quinoa seed extract, long-stem grape fern extract, alfalfa extract, and lanceolate spikenard extract so that the active ingredients are better matched in a specific ratio, thereby exerting a more significant synergistic effect and a more significant effect on repairing sensitive skin.

[0022] 3. In this application, the specific selection of butylene glycol and sodium hyaluronate has a better moisturizing effect. When combined with the composite plant extract, it can better promote the repair of the skin barrier. DETAILED DESCRIPTION

[0023] The present application is further described in detail below with reference to the embodiments.

[0024] Example 1 A composition suitable for repairing and soothing skin barriers, comprising the following components: Solvent, humectant, complex plant extract, skin conditioning agent, preservative.

[0025] The solvent is deionized water.

[0026] The moisturizer is a combination of butylene glycol and sodium hyaluronate.

[0027] Butanediol was purchased from Wanhua Chemical Group Co., Ltd., 1,3-butanediol.

[0028] Sodium hyaluronate was purchased from Shandong Focus Freda Biological Co., Ltd.

[0029] The compound plant extract is a combination of quinoa seed extract, long-stem grape fern extract, alfalfa extract, and spoon-leaved spikenard extract.

[0030] Quinoa seed extract was purchased from Guangzhou Yuefeng Biotechnology Co., Ltd.

[0031] The long stem grape fern algae extract was purchased from Guangzhou Yuefeng Biotechnology Co., Ltd.

[0032] Alfalfa extract was purchased from Guangzhou Yuefeng Biotechnology Co., Ltd.

[0033] Nardostachys lanceolata extract was purchased from Guangzhou Yuefeng Biotechnology Co., Ltd.

[0034] The skin conditioning agent was pyridoxine, purchased from DSM Nutritional Products Ltd.

[0035] The preservative is a combination of p-hydroxyacetophenone and 1,2-hexanediol.

[0036] Parahydroxyacetophenone was purchased from Beijing Tianhong Tianda Pharmaceutical Technology Co., Ltd.

[0037] 1,2-Hexanediol was purchased from SHINSUNG MATERIALS Co., LTD.

[0038] The preparation method of the composition suitable for skin barrier repair and soothing is as follows: Step 1) 46.12 kg of deionized water, 28 kg of butanediol, and 0.18 kg of sodium hyaluronate were added to a stirring vessel, heated to 80° C., rotated at 100 r / min, and stirred for 30 min to obtain a premix.

[0039] Step 2) The premix was cooled to 35 ° C., and then 9.5 kg of quinoa seed extract, 4.8 kg of long-stem grape fern extract, 4.8 kg of alfalfa extract, 2.9 kg of spathiphyllum extract, 2.9 kg of pyridoxine, 0.4 kg of p-hydroxyacetophenone, and 0.4 kg of 1,2-hexanediol were added to the premix at a speed of 100 r / min and stirred for 15 minutes to obtain a composition suitable for skin barrier repair and soothing.

[0040] Example 2 A composition suitable for repairing and soothing skin barriers, comprising the following components: Solvent, humectant, complex plant extract, skin conditioning agent, preservative.

[0041] The solvent is deionized water.

[0042] The moisturizer is a combination of butylene glycol and sodium hyaluronate.

[0043] Butanediol was purchased from Wanhua Chemical Group Co., Ltd., 1,3-butanediol.

[0044] Sodium hyaluronate was purchased from Shandong Focus Freda Biological Co., Ltd.

[0045] The compound plant extract is a combination of quinoa seed extract, long-stem grape fern extract, alfalfa extract, and spoon-leaved spikenard extract.

[0046] Quinoa seed extract was purchased from Guangzhou Yuefeng Biotechnology Co., Ltd.

[0047] The long stem grape fern algae extract was purchased from Guangzhou Yuefeng Biotechnology Co., Ltd.

[0048] Alfalfa extract was purchased from Guangzhou Yuefeng Biotechnology Co., Ltd.

[0049] Nardostachys lanceolata extract was purchased from Guangzhou Yuefeng Biotechnology Co., Ltd.

[0050] The skin conditioning agent was pyridoxine, purchased from DSM Nutritional Products Ltd.

[0051] The preservative is a combination of p-hydroxyacetophenone and 1,2-hexanediol.

[0052] Parahydroxyacetophenone was purchased from Beijing Tianhong Tianda Pharmaceutical Technology Co., Ltd.

[0053] 1,2-Hexanediol was purchased from SHINSUNG MATERIALS Co., LTD.

[0054] The preparation method of the composition suitable for skin barrier repair and soothing is as follows: Step 1) 42.8 kg of deionized water, 30 kg of butanediol, and 0.2 kg of sodium hyaluronate were added to a stirring vessel, heated to 82.5° C., rotated at 100 r / min, and stirred for 30 min to obtain a premix.

[0055] Step 2) The premix is ​​cooled to 37.5° C., and then 10 kg of quinoa seed extract, 5 kg of long-stem grape fern extract, 5 kg of alfalfa extract, 3 kg of lanceolate extract, 3 kg of pyridoxine, 0.5 kg of p-hydroxyacetophenone, and 0.5 kg of 1,2-hexanediol are added to the premix at a speed of 100 r / min and stirred for 15 minutes to obtain a composition suitable for skin barrier repair and soothing.

[0056] Example 3 A composition suitable for repairing and soothing skin barriers, comprising the following components: Solvent, humectant, complex plant extract, skin conditioning agent, preservative.

[0057] The solvent is deionized water.

[0058] The moisturizer is a combination of butylene glycol and sodium hyaluronate.

[0059] Butanediol was purchased from Wanhua Chemical Group Co., Ltd., 1,3-butanediol.

[0060] Sodium hyaluronate was purchased from Shandong Focus Freda Biological Co., Ltd.

[0061] The compound plant extract is a combination of quinoa seed extract, long-stem grape fern extract, alfalfa extract, and spoon-leaved spikenard extract.

[0062] Quinoa seed extract was purchased from Guangzhou Yuefeng Biotechnology Co., Ltd.

[0063] The long stem grape fern algae extract was purchased from Guangzhou Yuefeng Biotechnology Co., Ltd.

[0064] Alfalfa extract was purchased from Guangzhou Yuefeng Biotechnology Co., Ltd.

[0065] Nardostachys lanceolata extract was purchased from Guangzhou Yuefeng Biotechnology Co., Ltd.

[0066] The skin conditioning agent was pyridoxine, purchased from DSM Nutritional Products Ltd.

[0067] The preservative is a combination of p-hydroxyacetophenone and 1,2-hexanediol.

[0068] Parahydroxyacetophenone was purchased from Beijing Tianhong Tianda Pharmaceutical Technology Co., Ltd.

[0069] 1,2-Hexanediol was purchased from SHINSUNG MATERIALS Co., LTD.

[0070] The preparation method of the composition suitable for skin barrier repair and soothing is as follows: Step 1) 39.48 kg of deionized water, 32 kg of butanediol, and 0.22 kg of sodium hyaluronate were added to a stirring vessel, heated to 85° C., rotated at 100 rpm, and stirred for 30 minutes to obtain a premix.

[0071] Step 2) The premix was cooled to 40 ° C, and then 10.5 kg of quinoa seed extract, 5.2 kg of long-stem grape fern extract, 5.2 kg of alfalfa extract, 3.1 kg of spoon-leaved spikenard extract, 3.1 kg of pyridoxine, 0.6 kg of p-hydroxyacetophenone, and 0.6 kg of 1,2-hexanediol were added to the premix at a speed of 100 r / min and stirred for 15 minutes to obtain a composition suitable for skin barrier repair and soothing.

[0072] Comparative Example 1 A composition suitable for repairing and soothing the skin barrier, which differs from Example 2 only in that: In the complex plant extract, grape seed extract is used in equal amounts to replace quinoa seed extract.

[0073] Grape seed extract was purchased from Shaanxi Junhe Biotechnology Co., Ltd.

[0074] Comparative Example 2 A composition suitable for repairing and soothing the skin barrier, which differs from Example 2 only in that: In the complex plant extract, an equal amount of horse chestnut extract is used to replace the long-stemmed grape fern extract.

[0075] The horse chestnut extract was purchased from Baoji Liupanyun Biotechnology Co., Ltd.

[0076] Comparative Example 3 A composition suitable for repairing and soothing the skin barrier, which differs from Example 2 only in that: In the complex plant extract, an equal amount of Centella asiatica extract is used to replace the alfalfa extract.

[0077] Centella asiatica extract was purchased from Guangzhou Huayu Biotechnology Co., Ltd.

[0078] Comparative Example 4 A composition suitable for repairing and soothing the skin barrier, which differs from Example 2 only in that: In the complex plant extract, an equal amount of honeysuckle extract is used to replace the spikenard extract.

[0079] Honeysuckle extract was purchased from Xi'an Wuling Biotechnology Co., Ltd.

[0080] Comparative Example 5 A combination suitable for skin barrier repair and soothing, the only difference is: In the complex plant extracts, grape seed extract is used to replace quinoa seed extract in equal amounts, horse chestnut extract is used to replace long-stem grape fern extract in equal amounts, Centella asiatica extract is used to replace alfalfa extract in equal amounts, and honeysuckle extract is used to replace spoon-leaved spikenard extract in equal amounts.

[0081] Grape seed extract was purchased from Shaanxi Junhe Biotechnology Co., Ltd.

[0082] The horse chestnut extract was purchased from Baoji Liupanyun Biotechnology Co., Ltd.

[0083] Centella asiatica extract was purchased from Guangzhou Huayu Biotechnology Co., Ltd.

[0084] Honeysuckle extract was purchased from Xi'an Wuling Biotechnology Co., Ltd.

[0085] Experiment 1 According to T / SHRH 006-2018 "Cosmetics - Free Radical (DPPH) Scavenging Experimental Method", the DPPH free radical scavenging rate (%) of the test sample prepared from the composition suitable for skin barrier repair and soothing of each embodiment and comparative example was detected.

[0086] Sample to be tested: 3 g of a composition suitable for skin barrier repair and soothing, 97 g of deionized water, mixed evenly to obtain a sample to be tested.

[0087] Experiment 2 According to T / JSRH 003-2023 "Hyaluronidase Inhibition Method for Anti-allergic Activity Test of Cosmetic Raw Materials", the hyaluronidase inhibition rate (%) of the test samples prepared from the compositions suitable for skin barrier repair and soothing in each embodiment and comparative example was tested.

[0088] Sample to be tested: 3 g of a composition suitable for skin barrier repair and soothing, 97 g of deionized water, mixed evenly to obtain a sample to be tested.

[0089] Experiment 3 Cellular inflammatory factor inhibition experiment, the experimental method is as follows: (1) Cell inoculation: Macrophages (mouse mononuclear macrophage leukemia cell line RAW264.7, purchased from the Cell Bank of the Chinese Academy of Sciences, catalog number: TCM13) were diluted with cell culture medium to a seeding density (the degree of confluence reached 45%-60% 24 h after inoculation), inoculated into 96-well plates with a volume of 200 μL per well, and placed in a CO2 incubator for 24 ± 2 h.

[0090] (2) Administration: Discard the culture medium in the 96-well plate and proceed with the induction and administration procedures. Add the test substance and 1 μg / mL LPS culture medium at a volume ratio of 1:1 to the test substance wells, add LPS-containing cell culture medium to the negative control wells, and add cell culture medium to the blank control wells, 200 μL per well, and continue culturing in a CO2 incubator for 24 ± 2 h.

[0091] (3) Collection of cell supernatant: After the incubation, collect 200 μL of cell culture supernatant into a 1.5 mL sterile centrifuge tube and store it in a -80°C ultra-low temperature freezer.

[0092] (4) ELISA test: The test was performed according to the operating instructions of the TNF-α ELISA test kit.

[0093] Test substance: 3 g of a composition suitable for skin barrier repair and soothing and 97 g of deionized water are mixed evenly to obtain the test substance.

[0094] Experiment 4 A number of female volunteers aged 20-30 were recruited and randomly divided into groups of 10. Each group was tested using the test samples prepared from the compositions suitable for skin barrier repair and soothing according to the embodiments and comparative examples.

[0095] Sample to be tested: 3 g of a composition suitable for skin barrier repair and soothing, 97 g of deionized water, mixed evenly to obtain a test substance.

[0096] Experimental process: Volunteers use the test sample once in the morning and once in the evening. Before use, clean their face with clean water and a disposable face towel, then apply 5ml of the test sample on the face until the skin is completely absorbed. Use it continuously for 30 days.

[0097] On the 31st day, stop using the test sample, clean your face with clean water and a disposable face towel, wait for 10 minutes and then test the skin moisture content, which is recorded as the initial skin moisture content. Then, move freely for 8 hours and test the skin moisture content again, which is recorded as the skin moisture content after 8 hours. The health of the skin barrier is determined by comparing the skin moisture content after 8 hours with the initial skin moisture content. The greater the decrease in skin moisture content after 8 hours compared to the initial skin moisture content, the more severe the skin barrier damage.

[0098] When testing the skin moisture content, the facial skin is tested using the skin moisture meter Corneometer CM825. The higher the measured value, the higher the skin moisture content.

[0099] The specific experimental data of Experiments 1-4 are shown in Table 1.

[0100] Table 1 According to the data comparison of each embodiment and comparative example in Table 1, each embodiment is significantly better than each comparative example in the effects of scavenging free radicals, soothing skin, anti-inflammation and repairing skin barrier. It can be seen that each embodiment can achieve good synergistic effect through the compounding of quinoa seed extract, long-stem grape fern extract, alfalfa extract and lanceolate extract, and can simultaneously have multiple effects of repairing sensitive skin, so that the repair effect of sensitive skin is faster and more significant.

[0101] Although other plant extracts with the effect of repairing sensitive skin were added to each comparative example, the synergistic effect of the compounded plant extracts in each comparative example was far inferior to that of the embodiments. As a result, although each comparative example had certain effects in scavenging free radicals, soothing the skin, anti-inflammation and repairing the skin barrier, the overall effect was relatively general and could not meet the needs of quickly repairing sensitive skin.

[0102] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A composition suitable for repairing and soothing the skin barrier, characterized in that: The composition includes the following parts by weight: 39.48-46.12 parts of solvent; 28.18-32.22 parts of moisturizer; 22-24 parts of compound plant extract; 2.9-3.1 parts of skin conditioning agent; 0.8-1.2 parts of preservatives; The composite plant extract is a combination of quinoa seed extract, long-stem grape fern extract, alfalfa extract and spikenard extract.

2. A composition suitable for skin barrier repair and soothing according to claim 1, characterized in that: In the composite plant extract, the mass ratio of quinoa seed extract, long stem grape fern extract, alfalfa extract and spikenard extract is 9.5-10.5:4.8-5.2:4.8-5.2:2.9-3.

1.

3. The composition for skin barrier repair and soothing according to claim 1, characterized in that: The moisturizing agent is a compound of butylene glycol and sodium hyaluronate.

4. The composition for skin barrier repair and soothing according to claim 3, characterized in that: In the moisturizing agent, the mass ratio of butylene glycol to sodium hyaluronate is 28-32:0.18-0.

22.

5. The composition for skin barrier repair and soothing according to claim 1, characterized in that: The skin conditioning agent is pyridoxine.

6. The composition for skin barrier repair and soothing according to claim 1, characterized in that: The preservative is a compound of p-hydroxyacetophenone and 1,2-hexanediol, and the mass ratio of the p-hydroxyacetophenone to the 1,2-hexanediol is 0.4-0.6:0.4-0.

6.

7. The composition for skin barrier repair and soothing according to claim 1, characterized in that: The solvent is deionized water.

8. A method for preparing the composition for skin barrier repair and soothing according to any one of claims 1 to 7, characterized in that: The following steps are involved: Step 1), mixing the solvent and the moisturizer at 80-85° C. to obtain a premix; Step 2) Cool the premix to 35-40° C., then add the composite plant extract, skin conditioner, and preservative to the premix and mix well to obtain a composition suitable for skin barrier repair and soothing.

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