High-efficiency mild unhairing cosmetic and preparation method thereof

Abstract

The invention relates to the technical field of cosmetics, and discloses a high-efficiency mild depilation cosmetic and a preparation method thereof, and the raw materials of the depilation cosmetic comprise, by weight, 8-10% of bromelain; 10%-12% of a turmeric root extract; 9%-11% of a calendula extract; 6%-9% of an aloe extract; 4%-7% of a soybean extract; 7%-10% of calcium thioglycolate; 2%-5% of L-cysteine; 1%-3% of sodium bicarbonate; 3%-6% of green tea polyphenol; 2%-4% of a chamomile extract; 1%-3% of dipotassium glycyrrhizinate; 0.9%-2.3% of a peptide component; 0.5%-1% of rosmarinic acid; 1%-3% of vitamin E; 2%-4% of gluconic acid; 4%-5% of beewax; 5%-10% of an emulsifier; according to the invention, dipotassium glycyrrhizinate and the chamomile extract form a dual anti-allergy barrier, the physical protection effect of aloe polysaccharide is combined to reduce skin irritation, and the turmeric root extract and the peptide component prolong the hair follicle resting period and reduce the hair regeneration rate, so that the safer and more effective hair removal cosmetic is prepared.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, in particular to a highly effective and mild depilatory cosmetic and a preparation method thereof. Background Art

[0002] With the improvement of people's quality of life and the growing demand for beautiful skin, the care and management of body hair has gradually become an important topic in the field of modern beauty. Especially in summer, the exposure of body hair such as hair on the hands, feet, and armpits seriously affects personal image, which has led to the rapid development of the hair removal preparation market. However, existing hair removal preparations still face multiple technical bottlenecks in actual application: First, the hair removal effect is not thorough, and hair roots or hair shaft sections often remain, making it difficult to achieve the goal of long-lasting and smooth hair removal; second, although the strong chemical ingredients added to improve hair removal efficiency can destroy the keratin structure, their strong corrosiveness can easily cause skin redness, swelling, and allergic reactions; other alternative ingredients such as ammonium thioglycolate are limited by alkaline intolerance and odor problems, thioglycolates aggravate skin irritation due to the excessive activity of metal ions, and the relatively mild calcium thioglycolate faces the dual challenges of insufficient hair removal efficiency and difficulty in dosage control. More significantly, the hair regrowth cycle after hair removal is shortened, and newly grown hair becomes coarser, harder, and denser, forcing users to frequently increase dosage and shorten use intervals. This creates a vicious cycle of "the more hair is removed, the coarser it becomes – the more frequent it is, the more sensitive it becomes," severely limiting the practicality and user experience of hair removal preparations. These technical pain points urgently require breakthroughs through innovative formulations and process optimization. Summary of the Invention

[0003] (1) Technical problems solved

[0004] In response to the shortcomings of the existing technology, the present invention provides a highly efficient and mild depilatory cosmetic and its preparation method, which has the advantages of thorough depilation, low irritation and inhibition of hair regrowth, and solves the problems of traditional depilatory preparations such as residual hair roots, easy skin irritation, and coarse and dense hair regrowth after depilation.

[0005] (2) Technical solution

[0006] To achieve the above-mentioned object, the present invention provides the following technical solution: a highly effective and mild depilatory cosmetic, wherein the raw materials and their weight ratios of the depilatory cosmetic include: 8% to 10% bromelain; 10% to 12% turmeric root extract; 9% to 11% calendula extract; 6% to 9% aloe extract; 4% to 7% soybean extract; 7% to 10% calcium thioglycolate; 2% to 5% L-cysteine; 1% to 3% sodium bicarbonate; 3% to 6% green tea polyphenols; 2% to 4% chamomile extract; 1% to 3% dipotassium glycyrrhizate; 0.9% to 2.3% peptide components; 0.5% to 1% rosmarinic acid; 1% to 3% vitamin E; 2% to 4% gluconic acid; 4% to 5% beeswax; 5% to 10% emulsifier; and the remaining raw materials are pure water.

[0007] Preferably, the bromelain is prepared by stirring and extracting fresh pineapple stem crushed material with a phosphate buffer solution having a pH of 7.0-7.5 at a low temperature of 2-4° C. for 6-8 hours.

[0008] Preferably, the concentration of the turmeric root extract, calendula extract and chamomile extract is between 98% and 100%.

[0009] Preferably, the L-cysteine ​​is formed by a reduction reaction between cystine and sodium bisulfite in a weakly alkaline environment. The disulfide bond in the cysteine ​​molecule is reduced and broken by sodium bisulfite to generate two L-cysteine ​​molecules. The reaction formula is: C6H 12 N2O4S2 cystine + 2HSO3 - →2C3H7NO2S+2SO4 2- Among them, C6H 12 N2O4S2 represents cystine, and C3H7NO2S represents L-cysteine.

[0010] Preferably, the peptide component consists of biotin tripeptide-1 and undecapeptide-10 in a ratio of 2:1.

[0011] A method for preparing a highly effective and mild depilatory cosmetic is provided, which is prepared according to the raw materials and weight ratios of the highly effective and mild depilatory cosmetic described above, and comprises the following steps: Step 1. Prepare the ingredients: prepare the formula ratio of bromelain, turmeric root extract, calendula extract, aloe extract, soybean extract, calcium thioglycolate, L-cysteine, sodium bicarbonate, green tea polyphenols, chamomile extract, dipotassium glycyrrhizate, peptide ingredients, rosmarinic acid, vitamin E, gluconic acid, beeswax, emulsifier and purified water; Step 2: Pretreatment of raw materials: using glycerol to stimulate the enzymatic activity of bromelain, using ultrasonic dispersion of turmeric root extract, calendula extract and green tea polyphenols, and pre-dissolving calcium thioglycolate and L-cysteine; Step 3: Functional modular mixing: The enzyme system consisting of pretreated bromelain, calcium thioglycolate, L-cysteine, sodium bicarbonate and 1 / 3 rosmarinic acid is mixed with turmeric root extract, calendula extract and green tea polyphenols to prepare the hair removal core group; dipotassium glycyrrhizate, chamomile extract and the remaining pure water are mixed to form the anti-allergic sustained-release group; the remaining 2 / 3 rosmarinic acid and peptide components are used to form the regeneration inhibition group; Step 4, low-temperature gradient emulsification: melt beeswax, vitamin E and emulsifier, then add gluconic acid to prepare the oil phase, mix the hair removal core group, anti-allergic slow-release group and regeneration inhibition group, add soybean extract and aloe extract to prepare the water phase, slowly inject the oil phase into the water phase under the condition of controlling the temperature ≤40°C, and perform ultrasonic vibration to obtain the emulsified component; Step 5: Forming: Remove microbubbles from the emulsified components under a vacuum degree of -0.08 to -0.05 MPa to maintain the stability of the system, and refrigerate and solidify at 8-10°C for 1.5-2 hours to obtain a semi-solid gel hair removal cosmetic.

[0012] Preferably, in step 2, the raw material is pretreated as follows: bromelain and glycerol are premixed in a constant temperature water bath at a ratio of 2:1 for 30 minutes at 35-40° C., and then sodium bicarbonate is added to adjust the pH of the premixed solution to 6.8-7.2 to form an enzyme stabilizing buffer system.

[0013] Preferably, the turmeric root extract, calendula extract, green tea polyphenols and olive oil ester ethoxylate are mixed and dispersed at 45-50°C and 1500-2000 rpm for 15-20 minutes to form a nano-scale plant composite colloid; the calcium thioglycolate and L-cysteine ​​are dissolved in pure water at 5-8°C and ultrasonically treated for 8-10 minutes until completely dissolved.

[0014] Preferably, the functional modular mixing in step three is: S3.1. Preparation of the depilatory core phase: Stir at 40-45°C and 500-600 rpm for 10-15 minutes under nitrogen to form a depilatory active matrix; S3.2. Preparation conditions of the anti-allergic sustained-release group: Nanogels were formed by microfluidizer homogenization at a pressure of 100-200 MPa; S3.3. Preparation conditions of the regeneration inhibition group: Targeted binding is performed by electroporation technology at -5 to 0°C to form a hair follicle stem cell inhibitory complex.

[0015] Preferably, the low temperature gradient emulsification process in step 4: S4.1. Oil phase preparation: Melt beeswax, vitamin E, and emulsifier at 55-60°C, and add gluconic acid to adjust polarity. S4.2. Prepare the aqueous phase: Mix the hair removal core phase, anti-allergic slow-release system, and regeneration inhibitor in a ratio of 5:3:2, add soybean extract and aloe extract, and maintain the temperature ≤ 40°C; S4.3. Preparation of emulsified components: slowly inject the oil phase into the water phase to form a primary emulsion under shearing at 1500-2000 rpm. The primary emulsion is refined by a high-pressure homogenizer to a particle size of <5 μm.

[0016] Compared with the prior art, the present invention provides a highly effective and mild hair removal cosmetic and a preparation method thereof, which has the following beneficial effects: 1. The present invention achieves the beneficial effects of shortening the depilatory time and improving the depilatory rate through the synergistic effect of bromelain and calcium thioglycolate, combined with the sulfhydryl reducing ability of L-cysteine. Under the preparation conditions of pH value of 7.1-7.4, the synergistic effect of bromelain and calcium thioglycolate can activate the reducing ability of the sulfhydryl group of L-cysteine, so that the depilatory time of the prepared depilatory cosmetic is shortened and the depilatory rate is increased.

[0017] 2. The present invention achieves the beneficial effect of reducing skin irritation by forming a double anti-allergic barrier through dipotassium glycyrrhizate and chamomile extract, combined with the physical protective effect of aloe polysaccharide. Among them, the synergistic effect of dipotassium glycyrrhizate and chamomile extract, combined with the moisturizing and physical protective functions of aloe polysaccharide, reduces the irritation in hair removal cosmetics.

[0018] 3. The present invention achieves the beneficial effects of prolonging the resting phase of hair follicles and reducing the hair regrowth rate by adopting a dual-pathway strategy of using turmeric root extract to inhibit the Wnt pathway and peptide components to block FGF5 signals. The synergistic effect of turmeric root extract and peptide components inhibits the regeneration ability of hair follicles through dual signaling pathways, thereby increasing the regeneration inhibition rate of scalp hair follicles during the use of hair removal cosmetics. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 A flow chart was prepared for the present invention. DETAILED DESCRIPTION

[0020] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0021] See also Figure 1 A highly effective and mild hair removal cosmetic. The raw materials and their weight ratios of the hair removal cosmetic include: 8% to 10% bromelain; 10% to 12% turmeric root extract; 9% to 11% calendula extract; 6% to 9% aloe extract; 4% to 7% soybean extract; 7% to 10% calcium thioglycolate; 2% to 5% L-cysteine; 1% to 3% sodium bicarbonate; 3% to 6% green tea polyphenols; 2% to 4% chamomile extract; 1% to 3% dipotassium glycyrrhizate; 0.9% to 2.3% peptide components; 0.5% to 1% rosmarinic acid; 1% to 3% vitamin E; 2% to 4% gluconic acid; 4% to 5% beeswax; 5% to 10% emulsifier; and the remaining raw materials are pure water.

[0022] Its functions are shown in Table 1 below: Table 1

[0023] The advantages are: through the synergistic effect of bromelain and calcium thioglycolate, combined with the sulfhydryl reducing ability of L-cysteine, the hair removal rate is improved; the double anti-allergic barrier formed by dipotassium glycyrrhizate and chamomile extract, combined with the physical protection of aloe polysaccharides, reduces skin irritation; the dual-pathway strategy of turmeric root extract inhibiting the Wnt pathway and peptide components blocking the FGF5 signal prolongs the resting phase of hair follicles and reduces the hair regrowth rate, solving the contradiction between the efficacy, irritation and regeneration inhibition of traditional depilatories, and providing a safer and more effective hair removal option.

[0024] Specifically, bromelain is prepared by stirring and extracting fresh pineapple stem crushed material with phosphate buffer with a pH of 7.0-7.5 at a low temperature of 2-4°C for 6-8 hours. The enzyme activity is retained by low-temperature extraction (2-4°C), and the phosphate buffer maintains a stable pH. The obtained bromelain will achieve gentle hair removal by destroying the keratin structure in the hair.

[0025] Specifically, the concentrations of turmeric root extract, calendula extract, and chamomile extract are between 98% and 100%.

[0026] Specifically, L-cysteine ​​is formed by a reduction reaction between cystine and sodium bisulfite in a weakly alkaline environment. The disulfide bond (-SS-) in the cysteine ​​molecule is reduced and broken by sodium bisulfite to generate two L-cysteine ​​molecules. The reaction formula is: C6H 12 N2O4S2 cystine + 2HSO3 - →2C3H7NO2S+2SO4 2- Among them, C6H 12 N2O4S2 represents cystine, and C3H7NO2S represents L-cysteine. L-cysteine ​​forms a synergistic depilatory system with calcium thioglycolate in depilatory cosmetics. L-cysteine ​​provides free sulfhydryl groups (-SH) to activate the reduction reaction of the disulfide bonds (-SS-) of hair follicle keratin. The free sulfhydryl groups (-SH) of L-cysteine ​​(Cys) act as nucleophiles to attack the disulfide bonds (-SS-) in keratin, achieving cleavage through the following two-step reaction: Protein-SS-Protein+Cys-SH→Protein-SS-Cys+H + Among them, mixed disulfide intermediates are formed; Protein-SS-Cys+Cys-SH→Protein-SH+Cys-S-Cys Among them, the disulfide bonds are completely broken to generate reduced keratin and L-cysteine ​​dimers.

[0027] Specifically, the peptide component is composed of biotin tripeptide-1 and undecapeptide-10 in a ratio of 2:1.

[0028] Specifically, a method for preparing a highly effective and mild depilatory cosmetic is prepared according to the raw materials and weight ratios of the highly effective and mild depilatory cosmetic described above, comprising the following preparation steps: Step 1. Prepare the ingredients: prepare the formula ratio of bromelain, turmeric root extract, calendula extract, aloe extract, soybean extract, calcium thioglycolate, L-cysteine, sodium bicarbonate, green tea polyphenols, chamomile extract, dipotassium glycyrrhizate, peptide ingredients, rosmarinic acid, vitamin E, gluconic acid, beeswax, emulsifier and purified water; Step 2: Pretreatment of raw materials: using glycerol to stimulate the enzymatic activity of bromelain, using ultrasonic dispersion of turmeric root extract, calendula extract and green tea polyphenols, and pre-dissolving calcium thioglycolate and L-cysteine; Step 3: Functional modular mixing: The enzyme system consisting of pretreated bromelain, calcium thioglycolate, L-cysteine, sodium bicarbonate and 1 / 3 rosmarinic acid is mixed with turmeric root extract, calendula extract and green tea polyphenols to prepare the hair removal core group; dipotassium glycyrrhizate, chamomile extract and the remaining pure water are mixed to form the anti-allergic sustained-release group; the remaining 2 / 3 rosmarinic acid and peptide components are used to form the regeneration inhibition group; Step 4, low-temperature gradient emulsification: melt beeswax, vitamin E and emulsifier, then add gluconic acid to prepare the oil phase, mix the hair removal core group, anti-allergic slow-release group and regeneration inhibition group, add soybean extract and aloe extract to prepare the water phase, slowly inject the oil phase into the water phase under the condition of controlling the temperature ≤40°C, and perform ultrasonic vibration to obtain the emulsified component; Step 5: Forming: Remove microbubbles from the emulsified components under a vacuum degree of -0.08 to -0.05 MPa to maintain the stability of the system, and refrigerate and solidify at 8-10°C for 1.5-2 hours to obtain a semi-solid gel hair removal cosmetic.

[0029] Specifically, through the synergistic effect of bromelain and calcium thioglycolate, combined with the sulfhydryl reducing ability of L-cysteine, the beneficial effects of shortening hair removal time and improving hair removal rate are achieved. Under the preparation conditions of pH value of 7.1-7.4, the synergistic effect of bromelain and calcium thioglycolate can activate the sulfhydryl reducing ability of L-cysteine, so that the prepared hair removal cosmetic has the advantages of shortening hair removal time and increasing hair removal rate.

[0030] Specifically, the double anti-allergic barrier formed by dipotassium glycyrrhizate and chamomile extract, combined with the physical protective effect of aloe polysaccharide, achieves the beneficial effect of reducing skin irritation. Among them, the synergistic effect of dipotassium glycyrrhizate and chamomile extract, combined with the moisturizing and physical protective functions of aloe polysaccharide, reduces the irritation in hair removal cosmetics.

[0031] Specifically, a dual-pathway strategy of turmeric root extract inhibiting the Wnt pathway and peptide ingredients blocking the FGF5 signal is used to achieve the beneficial effects of prolonging the resting phase of hair follicles and reducing the hair regeneration rate. Among them, the synergistic effect of turmeric root extract and peptide ingredients inhibits the regeneration ability of hair follicles through dual signal pathways, thereby increasing the regeneration inhibition rate of scalp hair follicles during the use of hair removal cosmetics.

[0032] Specifically, in step 2, the raw material pretreatment is as follows: bromelain and glycerol are premixed in a constant temperature water bath at a ratio of 2:1 for 30 minutes at 35-40° C. to activate enzyme activity, and then sodium bicarbonate is added to adjust the pH of the premixed solution to 6.8-7.2 to form an enzyme stabilizing buffer system.

[0033] Specifically, turmeric root extract, calendula extract, green tea polyphenols and olive oil ester ethoxylate are mixed and dispersed at a high shear speed of 1500-2000 rpm at 45-50°C for 15-20 minutes to form a nano-scale plant composite colloid; the calcium thioglycolate and L-cysteine ​​are dissolved in pure water at 5-8°C and ultrasonically treated for 8-10 minutes until completely dissolved to avoid oxidative inactivation.

[0034] Specifically, in step 3, the functional modularization is mixed: S3.1. Preparation of the depilatory core phase: Stir at 40-45°C and 500-600 rpm for 10-15 minutes under nitrogen to form a depilatory active matrix; S3.2. Preparation conditions of the anti-allergic sustained-release group: Nanogels were formed by microfluidizer homogenization at a pressure of 100-200 MPa; S3.3. Preparation conditions of the regeneration inhibition group: Targeted binding is performed by electroporation technology at -5 to 0°C to form a hair follicle stem cell inhibitory complex.

[0035] Specifically, the low-temperature gradient emulsification process in step 4: S4.1. Oil phase preparation: Melt beeswax, vitamin E, and emulsifier at 55-60°C, and add gluconic acid to adjust polarity. S4.2. Prepare the aqueous phase: Mix the hair removal core phase, anti-allergic slow-release system, and regeneration inhibitor in a ratio of 5:3:2, add soybean extract and aloe extract, and maintain the temperature ≤ 40°C; S4.3. Preparation of emulsified components: slowly inject the oil phase into the water phase and form a primary emulsion under shearing at 1500-2000 rpm. The primary emulsion is refined by a high-pressure homogenizer to a particle size of less than 5 μm, and ultrasonic vibration is used to break the bubbles to obtain the emulsified component.

[0036] According to the raw material specific gravity range of the present invention, Examples 1-4 were designed, and then the raw materials were deleted, added or replaced with the core raw materials to obtain Comparative Examples 1-4. The raw material formulas of Examples 1-4 and Comparative Examples 1-4 are as shown in Table 2. Table 2

[0037] The formulas of the embodiment and the comparative example were applied to actual production to prepare hair removal cosmetics, and the performance of the cosmetics was tested. The test data are shown in Table 3 below: Table 3

[0038] From Table 2-3 we can get: (1) Analysis from the perspective of the difference in depilatory efficiency: In the examples, bromelain (8%-10%) and calcium thioglycolate (7%-10%) act synergistically (enzyme-chemical dual-effect depilatory), activating the sulfhydryl reducing ability of L-cysteine ​​at pH 7.1-7.4, significantly shortening the depilatory time (≤8.5 minutes). In comparative example 1, bromelain was replaced with papain, and the depilatory time was extended to 12.3 minutes (papain had poor thermal stability and the lack of a low-temperature extraction process resulted in a loss of activity). In comparative example 4, the pH dropped to 5.2 due to the substitution of lactic acid for sodium bicarbonate (the acidic environment inhibited the activity of calcium thioglycolate), and the depilatory rate was only 72.3%.

[0039] (2) Analysis from the perspective of irritation control: In the examples, dipotassium glycyrrhizate (1% to 3%) and chamomile extract (2% to 4%) form a double anti-allergic barrier, combined with the physical protection of aloe polysaccharides (6% to 9%), and the Draize score is ≤ 0.4 (far below the safety threshold of 1.0). However, in comparative example 2, the addition of sodium hyaluronate (2%) causes an imbalance in the emulsification system (from O / W type to W / O type), and the active ingredient permeation overload causes irritation. In comparative example 3, the raw material lacks L-cysteine ​​(loss of thiol sustained-release protection), which causes the accumulation of oxidation byproducts in the finished product, resulting in increased irritation.

[0040] (3) Analysis from the perspective of regeneration inhibition effect: In the examples, turmeric root extract (10% to 12%) inhibits the Wnt pathway and peptide components (0.9% to 2.3%) block the FGF5 signal, and the dual pathways prolong the resting phase of hair follicles. However, comparative examples 1-4 lack the rosmarinic acid targeted loading process (lack of electroporation technology), which reduces the regeneration inhibition rate by 30% to 50%.

[0041] (4) Analysis from the aspects of stability and safety: In the examples, gluconic acid (2% to 4%) chelates metal ions to prevent enzyme oxidative inactivation, and beeswax (4% to 5%) constructs a temperature-responsive skeleton that forms a stable gel network after solidification at 8-10°C. However, in comparative example 4, the pH imbalance (5.2) caused by the addition of lactic acid triggers the oxidative rancidity of vitamin E, resulting in the lowest stability score for the finished product.

[0042] In summary, the embodiment has the best comprehensive performance, with a finished product hair removal rate of ≥97.5%, an irritation of ≤0.4, and a regeneration inhibition rate of ≥78.6%. This verifies the ternary synergistic system of bromelain, calcium thioglycolate, and L-cysteine ​​in the formula of the present invention, successfully resolving the "efficacy-stimulation-regeneration" contradiction of traditional depilatories.

[0043] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A highly effective and mild hair removal cosmetic, characterized in that: The raw materials and their weight ratios of the depilatory cosmetics include: 8% to 10% bromelain; 10% to 12% turmeric root extract; 9% to 11% calendula extract; 6% to 9% aloe extract; 4% to 7% soybean extract; 7% to 10% calcium thioglycolate; 2% to 5% L-cysteine; 1% to 3% sodium bicarbonate; 3% to 6% green tea polyphenols; 2% to 4% chamomile extract; 1% to 3% dipotassium glycyrrhizate; 0.9% to 2.3% peptide components; 0.5% to 1% rosmarinic acid; 1% to 3% vitamin E; 2% to 4% gluconic acid; 4% to 5% beeswax; 5% to 10% emulsifier; and the remaining raw materials are pure water.

2. The highly effective and mild hair removal cosmetic according to claim 1, characterized in that: The bromelain is prepared by stirring and extracting fresh pineapple stem crushed material with a phosphate buffer solution with a pH value of 7.0-7.5 at a low temperature of 2-4° C. for 6-8 hours.

3. The highly effective and mild hair removal cosmetic according to claim 1, characterized in that: The concentrations of the turmeric root extract, the calendula extract and the chamomile extract are between 98% and 100%.

4. The highly effective and mild hair removal cosmetic according to claim 1, characterized in that: The L-cysteine ​​is formed by a reduction reaction between cystine and sodium bisulfite in a weakly alkaline environment. The disulfide bond in the cysteine ​​molecule is reduced and broken by sodium bisulfite to generate two L-cysteine ​​molecules. The reaction formula is: C6H 12 N2O4S2 cystine + 2HSO3 - →2C3H7NO2S+2SO4 2- Among them, C6H 12 N2O4S2 represents cystine, and C3H7NO2S represents L-cysteine.

5. The highly effective and mild hair removal cosmetic according to claim 1, characterized in that: The peptide component consists of biotin tripeptide-1 and undecapeptide-10 in a ratio of 2:

1.

6. A method for preparing an efficient and mild depilatory cosmetic, characterized in that: The raw materials and weight ratios of the high-efficiency and mild hair removal cosmetic according to claim 1 are prepared, comprising the following preparation steps: Step 1. Prepare the ingredients: prepare the formula ratio of bromelain, turmeric root extract, calendula extract, aloe extract, soybean extract, calcium thioglycolate, L-cysteine, sodium bicarbonate, green tea polyphenols, chamomile extract, dipotassium glycyrrhizate, peptide ingredients, rosmarinic acid, vitamin E, gluconic acid, beeswax, emulsifier and purified water; Step 2: Pretreatment of raw materials: using glycerol to stimulate the enzymatic activity of bromelain, using ultrasonic dispersion of turmeric root extract, calendula extract and green tea polyphenols, and pre-dissolving calcium thioglycolate and L-cysteine; Step 3: Functional modular mixing: The enzyme system consisting of pretreated bromelain, calcium thioglycolate, L-cysteine, sodium bicarbonate and 1 / 3 rosmarinic acid is mixed with turmeric root extract, calendula extract and green tea polyphenols to prepare the hair removal core group; dipotassium glycyrrhizate, chamomile extract and the remaining pure water are mixed to form the anti-allergic sustained-release group; the remaining 2 / 3 rosmarinic acid and peptide components are used to form the regeneration inhibition group; Step 4, low-temperature gradient emulsification: melt beeswax, vitamin E and emulsifier, then add gluconic acid to prepare the oil phase, mix the hair removal core group, anti-allergic slow-release group and regeneration inhibition group, add soybean extract and aloe extract to prepare the water phase, slowly inject the oil phase into the water phase under the condition of controlling the temperature ≤40°C, and perform ultrasonic vibration to obtain the emulsified component; Step 5: Forming: Remove microbubbles from the emulsified components under a vacuum degree of -0.08 to -0.05 MPa to maintain the stability of the system, and refrigerate and solidify at 8-10°C for 1.5-2 hours to obtain a semi-solid gel hair removal cosmetic.

7. The method for preparing a highly effective and mild depilatory cosmetic according to claim 6, wherein: In the step 2, the raw material is pretreated as follows: bromelain and glycerol are premixed in a constant temperature water bath at a ratio of 2:1 for 30 minutes at 35-40° C., and then sodium bicarbonate is added to adjust the pH of the premixed solution to 6.8-7.2 to form an enzyme stabilizing buffer system.

8. The method for preparing a highly effective and mild depilatory cosmetic according to claim 6, wherein: The turmeric root extract, calendula extract, green tea polyphenols and olive oil ester ethoxylate are mixed and dispersed at a high speed of 1500-2000 rpm at 45-50° C. for 15-20 minutes to form a nano-scale plant composite colloid; the calcium thioglycolate and L-cysteine ​​are dissolved in pure water at 5-8° C. and ultrasonically treated for 8-10 minutes until they are completely dissolved.

9. The method for preparing a highly effective and mild depilatory cosmetic according to claim 6, wherein: Functional modular mixing in step three: S3.

1. Preparation of the depilatory core phase: Stir at 40-45°C and 500-600 rpm for 10-15 minutes under nitrogen to form a depilatory active matrix; S3.

2. Preparation conditions of the anti-allergic sustained-release group: Nanogels were formed by microfluidizer homogenization at a pressure of 100-200 MPa; S3.

3. Preparation conditions of the regeneration inhibition group: Targeted binding is performed by electroporation technology at -5 to 0°C to form a hair follicle stem cell inhibitory complex.

10. The method for preparing a highly effective and mild depilatory cosmetic according to claim 6, characterized in that: The low temperature gradient emulsification process in step 4: S4.

1. Oil phase preparation: Melt beeswax, vitamin E, and emulsifier at 55-60°C, and add gluconic acid to adjust polarity. S4.

2. Prepare the aqueous phase: Mix the hair removal core phase, anti-allergic slow-release system, and regeneration inhibitor in a ratio of 5:3:2, add soybean extract and aloe vera extract, and maintain the temperature ≤ 40°C; S4.

3. Preparation of emulsified components: slowly inject the oil phase into the water phase and form a primary emulsion under shearing at 1500-2000 rpm. The primary emulsion is refined by a high-pressure homogenizer to a particle size of <5 μm.

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