Slow release device and slow release system

Abstract

The embodiment of the invention provides a slow release device and a slow release system. The slow release device comprises a slow release device body, a first electrode, a second electrode and a slow release structure, the slow release device body is provided with a release through hole and a storage cavity, the release through hole is communicated with the liquid storage cavity, and the storage cavity is used for storing a to-be-released medium; the first electrode is fixed in the slow release device body and penetrates through the slow release structure; the second electrode is fixed in the slow release device body and is connected with the slow release structure; the slow release structure is provided with a plurality of groups of permeation holes selectively communicated with the release through hole, and at least two groups of permeation holes have different slow release rates for the to-be-released medium. According to the embodiment of the invention, the release rate of the to-be-released medium to the skin can be adjusted by adjusting the position of the permeation hole in the slow release structure and the electric field intensity of the first electrode and the second electrode.

Description

Technical Field

[0001] The present application relates to the technical field of medium sustained release, and in particular to a sustained release device and a sustained release system. Background Art

[0002] For example, nicotine active substances can be delivered via patches, oral preparations, or for user ingestion. However, these methods offer uncontrollable release rates, meaning users cannot adjust the release rate based on their needs. These methods are unsuitable for different user needs, hindering product usability. Summary of the Invention

[0003] In view of the above problems, the embodiments of the present application are proposed to provide a sustained-release device and a sustained-release system with a controllable release rate of a medium to be released.

[0004] In order to solve the above problems, the embodiment of the present application discloses a slow-release device, comprising: a slow-release device body, a first electrode, a second electrode and a slow-release structure;

[0005] The slow-release device body is provided with a release through-hole and a storage cavity, the release through-hole is in communication with the storage cavity, and the storage cavity is used to store the medium to be released; the first electrode is fixed in the slow-release device body and passes through the slow-release structure; the second electrode is fixed in the slow-release device body and is connected to the slow-release structure; the slow-release structure has multiple groups of permeation holes that can selectively communicate with the release through-hole, wherein at least two groups of the permeation holes have different slow-release rates for the medium to be released.

[0006] In one embodiment, at least two groups of the permeable pores form different sustained release rates based on different effective through-pore area ratios; the effective through-pore area ratios are determined based on the single pore area and the number of pores per unit area of ​​each group of permeable pores.

[0007] In one embodiment, the sustained-release structure includes a sustained-release control sheet, and the permeation hole penetrates the sustained-release control sheet.

[0008] In one embodiment, the slow-release structure is rotatably arranged relative to the slow-release device body, and the slow-release structure includes: at least two groups of the permeation holes evenly distributed along the circumferential direction of the slow-release control plate and with successively increasing pore sizes; the slow-release structure can be rotated relative to the slow-release device body so that one group of the permeation holes is opposite to and connected to the release through hole.

[0009] In one embodiment, the sustained-release structure further includes: an adjustment component coupled to the sustained-release control sheet, the adjustment component being used to adjust the relative position of the permeation hole and the sustained-release through hole, wherein when the permeation hole is connected to the sustained-release through hole, the permeation hole is in a working position.

[0010] In one embodiment, the adjustment assembly includes: a driven tooth provided on the outer edge of the slow-release control plate, and a driving gear engaged with the driven tooth and fixed on the slow-release device body.

[0011] In one embodiment, the slow release device further comprises a storage unit for storing the medium to be released, the storage unit is installed in the storage cavity, a liquid guide is provided in the storage cavity, and the liquid guide is used to allow the medium to be released in the storage unit to flow out through the release through hole.

[0012] In one embodiment, there are multiple storage cavities, which are arranged at intervals; each of the multiple storage cavities is connected to one of the multiple groups of permeation holes; and the storage unit is provided in a corresponding storage cavity among the multiple storage cavities.

[0013] In one embodiment, the liquid guide member is a liquid outlet needle, which includes a cylindrical needle head, and a plurality of liquid guide holes are provided on the side wall of the cylindrical needle head. The liquid outlet needle is used to pierce the storage unit and connect the medium to be released in the storage unit to the release through hole through the liquid guide hole.

[0014] The embodiment of the present application also discloses a sustained-release system, comprising a porous conductive matrix and the sustained-release device as described above, wherein the conductive matrix is ​​attached to the side of the sustained-release structure facing away from the sustained-release device body, and is used to absorb the medium to be released conducted by the permeable pores of the sustained-release structure.

[0015] The embodiments of the present application include the following advantages:

[0016] In the embodiment of the present application, a release through-hole and a storage cavity are provided on the body of the slow-release device, wherein the release through-hole is in communication with the storage cavity, and the storage cavity is used to store the medium to be released; a first electrode is fixed in the body of the slow-release device and passes through the slow-release structure; a second electrode is fixed in the body of the slow-release device and is connected to the slow-release structure; the slow-release structure has multiple groups of permeation holes that can be selectively connected to the release through-hole, wherein at least two groups of permeation holes have different release rates for the medium to be released. The current of the first electrode and the second electrode ionizes the medium to be released to form ions, and the ions are absorbed by the skin based on directional migration. The release rate of the medium to be released through the slow-release structure is also adjusted by adjusting the position of the permeation holes in the slow-release structure, so that the release rate of the medium to be released can be adjusted by adjusting the electric field strength of the first electrode and the second electrode and the position of the permeation holes in the slow-release structure to meet the needs of different users and improve the ease of use of the slow-release device. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is an exploded diagram of the structure of a sustained-release system of the present application;

[0018] Figure 2 A structural outline diagram of a sustained-release device of the present application;

[0019] Figure 3 This is a flowchart of the steps of an embodiment of a control method for a sustained-release device of the present application.

[0020] Description of reference numerals:

[0021] 100- slow release device body, 110- release through hole, 120- liquid guide member, 121- liquid guide hole;

[0022] 200-first electrode, 300 second electrode;

[0023] 400 - slow-release structure; 410 - permeation hole, 411 - first group of permeation holes, 412 - second group of permeation holes, 413 - third group of permeation holes, 414 - fully closed area, 420 - slow-release control plate, 430 - adjustment component, 431 - driving gear, 432 - driven gear;

[0024] 500-conductive matrix;

[0025] 600-position adjustment piece;

[0026] 700-electric field adjustment component;

[0027] 800-storage unit. DETAILED DESCRIPTION

[0028] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the present application is further described in detail below with reference to the accompanying drawings and specific implementation methods.

[0029] Reference Figure 1 , showing a structural exploded diagram of a sustained-release system of the present application, the sustained-release system includes a conductive matrix 500 and a sustained-release device, the conductive matrix 500 being attached to the side of the sustained-release structure 400 facing away from the sustained-release device body 100, and being used to adsorb the medium to be released conducted by the permeable holes 410 of the sustained-release structure 400.

[0030] The conductive matrix 500 can be attached to the side of the slow-release structure 400 facing away from the slow-release device body 100. Figure 1As shown, a conductive matrix 500 is disposed above the sustained-release structure 400; the conductive matrix 500, the sustained-release structure 400, and the sustained-release device body 100 are sequentially superimposed. The conductive matrix 500 can conduct the medium to be released through the permeable pores 410 of the sustained-release structure 400 and absorb the medium to be released flowing out of the permeable pores 410 of the sustained-release structure 400. The conductive matrix 500 can be an adsorption medium that absorbs the medium to be released, or it can be a porous adsorption medium structure. The conductive matrix 500 can be applied directly to the skin or applied via a skin patch, such as a plasma permeable membrane patch, to deliver the medium to be released to the user's skin. In some embodiments, because the conductive matrix 500 needs to be in long-term contact with the skin, it can be made of a medical-grade hydrogel conductive material. This material provides the conductive matrix 500 with excellent breathability and biocompatibility, ensuring a close fit with the skin and reducing irritation. Hydrogel materials can effectively absorb active substances such as nicotine solution, and their conductive properties can be combined with the iontophoresis function of the sustained-release device to improve transdermal absorption efficiency. The conductive matrix 500 may be planar, and the planar shape may be used to evenly distribute active substances such as nicotine solution, thereby preventing local excessive absorption and improving safety in use.

[0031] In summary, the medium to be released in the sustained-release device can flow out of the permeable pores 410 of the sustained-release structure 400. The released medium is then transferred to the conductive matrix 500, which then absorbs the medium. The conductive matrix 500 then contacts the user's skin, which absorbs the medium. The medium then enters the user's blood circulation, allowing it to exert its desired effect.

[0032] The present application discloses a sustained-release device, such as Figure 1 As shown, the slow-release device includes a slow-release body 100, a first electrode 200, a second electrode 300 and a slow-release structure 400;

[0033] The slow-release device body 100 is provided with a release through-hole 110 and a storage cavity, which are in communication with the release through-hole 110 and the storage cavity, and the storage cavity is used to store the medium to be released; the first electrode 200 is fixed in the slow-release device body 100 and passes through the slow-release structure 400; the second electrode 300 is fixed in the slow-release device body 100 and connected to the slow-release structure 100; the slow-release structure 100 has multiple groups of permeable holes 410 that can selectively communicate with the release through-hole 110, wherein at least two groups of permeable holes 410 have different release rates for the medium to be released.

[0034] In an embodiment of the present application, the release device may include a release device body 100, a first electrode 200, a second electrode 300, and a release structure 400. The release device body 100 is provided with a release hole 110. The release hole 110 may be located on a side of the release device body 100 near the release structure 400, and the release hole 110 is in communication with the storage chamber. The medium to be released within the storage chamber can flow out through the release hole 110. That is, the flow path of the medium to be released is from the storage chamber, through the release hole 110 to the release structure 400, and then out through any group of permeation holes 410 in the release structure 400. The release device body 100 serves as a supporting base for the first electrode 200, the second electrode 300, and the release structure 400. The medium to be released includes, but is not limited to, active substances such as nicotine agents, medicines, and plant extracts. For example, nicotine agents include nicotine and nicotine derivatives. Pharmaceutical active substances include, but are not limited to, nitroglycerin for relieving angina pectoris, fentanyl for chronic pain management, scopolamine for preventing motion sickness, and lidocaine for relieving postherpetic neuralgia. Plant extracts include, but are not limited to, menthol for pain relief and itching relief. Aloe vera extract, tea tree oil with antibacterial and anti-inflammatory properties, moisturizes and promotes wound healing, witch hazel extract for reducing oil secretion, and chamomile extract for soothing sensitive skin. The sustained-release device body 100 can integrate integrated circuits such as control circuits, batteries, and charging ports.

[0035] The sustained-release structure 400 can control the release rate of the medium to be released from the sustained-release device body 100, that is, the mass of the medium to be released from the storage chamber in the sustained-release device body 100 that flows out per unit time. The sustained-release structure can have multiple groups of permeation holes 410, each of which can be selectively connected to the release through-hole 110. At least two groups of permeation holes have different sustained-release rates for releasing the medium to be released into the skin patch 500. That is, among the multiple groups of permeation holes 410, at least two groups of permeation holes have different sustained-release rates, and the remaining permeation holes can have the same sustained-release rate as one of the groups of permeation holes. For example, the multiple groups of permeation holes 410 can be four groups of permeation holes: Group A, Group B, Group C, and Group D. In one example, these four groups of permeation holes can have different sustained-release rates, with the sustained-release rates of Group A, Group B, Group C, and Group D gradually increasing. In another example, among the four groups of permeation pores, there are permeation pores with the same sustained release rate and permeation pores with different sustained release rates; the sustained release rate of the permeation pores in group A is the same as that of the permeation pores in group B; the sustained release rate of the permeation pores in group B is less than the sustained release rate of the permeation pores in group C; and the sustained release rate of the permeation pores in group C is not greater than the sustained release rate of the permeation pores in group D.

[0036] The user can select one of the groups of permeation holes 410 as the permeation holes for the medium to be released through relevant operations. The medium to be released stored in the storage chamber of the slow-release device body 100 passes through the release through-holes 110 and then flows out through the selected permeation holes 410, such as flowing out onto the conductive matrix 500. When the conductive matrix 500 is attached to the user's skin, the medium to be released in the slow-release device body 100 enters the conductive matrix 500 through the permeation holes 410 in the working position of the slow-release structure 400. The medium to be released on the conductive matrix 500 enters the user's blood circulation based on the absorption capacity of the skin, so that the user can absorb it to achieve the corresponding effect. The slow-release structure 400 can be set on one side of the slow-release device body 100, and the slow-release device body 100 is in contact with the slow-release structure 400. The slow-release structure 400 can be embedded in or protrudes from the slow-release device body 100.

[0037] In one embodiment of the present application, a accommodating cavity 440 is provided on one side of the slow-release device body 100 near the slow-release structure 400. The accommodating cavity 440 is used to accommodate the slow-release structure 400 and the conductive matrix 500. The slow-release structure 400 and the conductive matrix 500 can be located in the accommodating cavity 440, making the structure of the slow-release device more compact and conducive to miniaturization.

[0038] The first electrode 200 and the second electrode 300 provide iontophoresis for the sustained-release device. The first electrode 200 is fixed within the sustained-release device body 100 and extends through the sustained-release structure 400, indirectly electrically connecting it to the conductive matrix 500 through the skin. The second electrode 300 is also fixed within the sustained-release device body 100 and in contact with the sustained-release structure 400. This means that the first electrode 200 and the second electrode 300 are connected to the human body via the sustained-release structure 400. For example, if ions form on the conductive matrix 500, their directional migration allows the skin to absorb the medium to be released more quickly. When the device is conducting, the circuit is, in this order: the second electrode 300, the conductive matrix 500, the human body, and the first electrode 200. Specifically, when different electric field strengths are applied to the first electrode 200 and the second electrode 300, the ion movement strengths within the conductive matrix 500 vary, thereby adjusting the release rate of the medium to be released.

[0039] Furthermore, to ensure stable transcutaneous current flow and reduce skin irritation, a flexible conductive gel can be provided on the outer surfaces of the first electrode 200 and the second electrode 300. This flexible conductive gel is utilized to contact the skin or the sustained-release structure 400. The flexible conductive gel is composed of a high molecular polymer network and a dissociable ionic electrolyte, achieving conductivity through ion migration. Furthermore, the first electrode 200 and the second electrode 300 can be silver / silver chloride electrodes, allowing them to quickly reach dynamic equilibrium with the solution containing the medium to be released. Furthermore, silver / silver chloride electrodes are harmless to the human body and are suitable for sustained-release devices in long-term contact with human skin.

[0040] In this embodiment, the release device body 100 is provided with a release hole 110 and a storage cavity, which are electrically connected to the release hole 110 and are used to store the medium to be released. A first electrode 200 is fixed in the release device body 100 and extends through the release structure 400. A second electrode 300 is fixed in the release device body 100 and connected to the release structure 100. The release structure 100 has multiple groups of permeable holes 410 that can selectively communicate with the release hole 110, wherein at least two groups of permeable holes 410 have different release rates for the medium to be released. The current passing through the first electrode 200 and the second electrode 300 forms ions on the conductive matrix 500. The directional migration of the ions changes the skin's absorption rate of the medium to be released, thereby changing the release rate of the medium to be released from the conductive matrix 500. By adjusting the position of the permeation holes in the slow-release structure 400, the slow-release rate of the medium to be released through the slow-release structure 400 is adjusted, so that the release rate of the medium to be released can be adjusted by adjusting the electric field strength of the first electrode 200 and the second electrode 300 and the position of the permeation holes in the slow-release structure 400 to meet the needs of different users and improve the convenience of use of the slow-release device.

[0041] In one embodiment of the present application, the sustained-release structure 400 includes a sustained-release control sheet 420 , and the permeation hole 410 penetrates the sustained-release control sheet 420 .

[0042] The sustained-release control sheet 420 is a flat plate-shaped component. The dimensions of the sustained-release control sheet 420 match those of the sustained-release device body 100, allowing the sustained-release control sheet 420 to be superimposed on the sustained-release device body 100. The sustained-release control sheet 420 may be located between the conductive matrix 500 and the sustained-release device body 100. At least two groups of permeation holes 410 penetrate the sustained-release control sheet 420. In other words, the sustained-release control sheet 420 has multiple groups of permeation holes extending through it. The sustained-release device body 100 located on one side of the sustained-release control sheet 420 can directly release its medium through these permeation holes into the conductive matrix 500 located on the other side of the sustained-release control sheet 420.

[0043] The sustained-release control sheet 420 can be manufactured from high-precision stainless steel, its surface precision-drilled to create permeable pores. High-precision stainless steel is made from stainless steel and, through precision machining techniques, achieves exceptionally high levels of dimensional accuracy, surface finish, and performance stability. Dimensional tolerances can be controlled within ±0.01 mm. The surface roughness (Ra) of high-precision stainless steel can be as low as 0.2 μm, free of scratches, cracks, and other defects. Mechanical polishing and electrolytic polishing processes achieve a mirror-like finish, enhancing the corrosion resistance of the sustained-release control sheet 420. High-precision stainless steel grades include 304, 316L, 2205, and 17-4PH. The composition of 304 stainless steel is: Cr (18-20%), Ni (8-10.5%), and C (≤0.08%). The composition of 316L stainless steel is: Cr (16-18%), Ni (10-14%), and Mo (2-3%). The composition of 2205 duplex stainless steel is: Cr (22%), Ni (4.5-6.5%), Mo (3%), N (0.14-0.2%). The composition of 17-4PH precipitation hardening stainless steel is: Cr (15-17.5%), Ni (3-5%), Cu (3-5%), Nb + Ta (0.15-0.45%).

[0044] In one embodiment of the present application, at least two groups of permeation holes form different sustained release rates based on different effective through-hole area ratios; the effective through-hole area ratio is determined based on the single pore area and the number of pores per unit area of ​​each group of permeation holes.

[0045] Different sustained release rates can be achieved by different effective through-hole area ratios of the permeation holes, that is, among the multiple groups of permeation holes, there are at least two groups of permeation holes with different effective through-hole area ratios.

[0046] In some embodiments, each group of permeable holes 410 has the same unit area on the sustained-release structure 400. The unit area can be the area occupied by each group of permeable holes 410 on the sustained-release structure 400. Figure 1 As shown, each group of permeation holes 410 occupies the same area on the sustained-release control sheet 420 of the sustained-release structure 400. Different permeation holes have different sustained-release rates based on different effective through-hole area ratios. The effective through-hole area ratio is the ratio of the area of ​​the group of permeation holes that can provide the medium to be released to the unit area. The effective through-hole area ratio is determined based on the single hole area and the number of holes in each group of permeation holes. On a unit area basis, the larger the single area of ​​the same number of holes or the greater the number of holes with the same area, the greater the sustained-release rate of the corresponding permeation hole; conversely, the smaller the area. Different effective through-hole areas and / or different numbers of holes form different sustained-release rates.

[0047] In some embodiments, the areas of each group of permeable holes 410 on the sustained-release structure 400 may not be completely the same.

[0048] In one embodiment of the present application, the slow-release structure 400 is rotatably arranged relative to the slow-release device body 100, and the slow-release structure 400 includes: at least two groups of the permeation holes evenly distributed along the circumferential direction of the slow-release control plate 420 and with successively increasing pore sizes, and the slow-release structure 400 can be rotated relative to the slow-release device body 100 so that one group of the permeation holes is opposite to and connected to the release through hole 110.

[0049] At least two groups of permeation holes 410 can be evenly distributed along the circumference of the sustained-release control sheet 420, and the distribution area of ​​at least two groups of permeation holes 410 is the same. And along the circumference of the sustained-release control sheet 420, the aperture of the permeation holes between each group increases in sequence. For example, you can refer to Figure 1 The at least two groups of permeation holes 410 may include three groups of permeation holes, including a first group of permeation holes 411, a second group of permeation holes 412, and a third group of permeation holes 413. The first group of permeation holes 411, the second group of permeation holes 412, and the third group of permeation holes 413 are evenly distributed along the circumference of the sustained-release control sheet 420. That is, the first group of permeation holes 411, the second group of permeation holes 412, and the third group of permeation holes 413 may each occupy a quarter of the sustained-release control sheet 420. That is, each 90-degree rotation can switch a group of permeation holes, and each 90-degree rotation can switch to a different pore size region, thereby achieving precise adjustment of the release rate.

[0050] The first group of permeation holes 411, the second group of permeation holes 412 and the third group of permeation holes 413 increase in diameter along the circumferential direction of the sustained-release control sheet 420. The diameter of the holes corresponds to the sustained-release rate, that is, the larger the diameter, the greater the sustained-release rate, and the smaller the diameter, the slower the release rate. Figure 1 Along the clockwise direction of the circumference of the sustained-release control sheet 420, the pore diameters of the first, second, and third groups of permeable pores 411, 412, and 413 increase sequentially. That is, the sustained-release rates of the first, second, and third groups of permeable pores 411, 412, and 413 increase sequentially. The sustained-release rate of the third group of permeable pores 413 is greater than that of the second group of permeable pores 412. The sustained-release rate of the second group of permeable pores 412 is greater than that of the first group of permeable pores 411. Because the sustained-release rates of the first, second, third, and fourth groups of permeable pores 411, 412, 413, and 414 increase sequentially, the pore diameters and permeabilities of the permeable pores increase and decrease layer by layer when adjusting the positions of the permeable pores. This allows the medium to be released onto the conductive matrix 500 to gradually increase and decrease, preventing localized overabsorption and ensuring safety in use.

[0051] In addition, a fully closed area 414 may be provided on the sustained-release control sheet 420, such as Figure 1 As shown, a fully closed region 414 is provided between the third group of permeable holes 413 and the first group of permeable holes 411. When rotated to the fully closed region 414, the slow-release control plate 420 blocks the medium to be released from the slow-release device body 100 on one side of the slow-release control plate 420 from entering the conductive matrix 500 on the other side of the slow-release control plate 420. The medium to be released from the slow-release device body 100 on one side of the slow-release control plate 420 cannot enter the other side of the slow-release control plate 420. This prevents the release of the medium from increasing, completely preventing the release of the medium. When the user selects the fully closed region 414, the release of the medium to be released is completely prevented, ensuring that the slow-release device does not release the medium unintentionally when not in use, improving the safety of the device and preventing leakage of the medium to be released. The working position can be the area within a predetermined width enclosed between the contact points of the first electrode 200 and the second electrode 300 on the slow-release control plate 420. The size of the predetermined width can be determined based on the structural dimensions and is not specifically limited in this embodiment of the present application.

[0052] In some embodiments, the slow-release structure 400 is slidably disposed relative to the slow-release device body 100, and the relative position of the slow-release structure 400 relative to the slow-release device body 100 is adjusted by sliding. For example, each time the slow-release structure 400 slides a unit distance, different groups of permeable holes 410 are adjusted to communicate with the release holes 110 of the slow-release device body 100. The actual size of the unit distance can be determined based on the actual size of the slow-release device and is not limited in this embodiment of the present application.

[0053] In some embodiments, the permeation holes 410 in each of the multiple groups of permeation holes 410 have the same pore diameter, but at least two groups of permeation holes 410 have different numbers of permeation holes 410, resulting in different release rates. A greater number of permeation holes 410 corresponds to a faster release rate; conversely, a smaller number of permeation holes 410 corresponds to a slower release rate.

[0054] In some embodiments, the sustained-release structure 400 further includes: an adjustment component 430 coupled to the sustained-release control sheet 420, the adjustment component 430 being used to adjust the relative position of the permeation hole 410 and the sustained-release through hole 410, wherein when the permeation hole 410 is connected to the sustained-release through hole 410, the permeation hole 400 is in a working position.

[0055] When the release through-hole 110 is connected to one of the groups of permeation holes 410, the permeation holes 410 are currently in the working position. The adjustment assembly 430 is kinematically coupled to the sustained-release control sheet 420. The adjustment assembly 430 can be used to adjust the position of the sustained-release control sheet 420, thereby adjusting the relative position of the permeation holes 410 relative to the sustained-release through-holes 410. This positions one of the groups of permeation holes 410 in the working position, allowing the medium to be released to the conductive matrix 500 to be released through this group of permeation holes.

[0056] In one embodiment of the present application, the adjustment assembly 430 includes: a driven tooth 432 disposed on the outer edge of the slow-release control piece 420 , and a driving gear 431 engaged with the driven tooth 432 and fixed to the slow-release device body 100 .

[0057] Adjustment assembly 430 can be adjusted using a gear transmission. Adjustment assembly 430 may include a driving gear 431 and driven gears 432. Driven gears 432 are disposed on the outer edge of the slow-release control plate 420. Driving gear 431 is disposed on the slow-release device body 100, and the driving gear 431 meshes with the driven gears 432. The transmission ratio between driving gear 431 and driven gear 432 can be set as needed. When driving gear 431 is rotated, driven gear 432 rotates accordingly. Therefore, by rotating the driving gear 431, the position of driven gear 432 can be adjusted, thereby adjusting the position of slow-release control plate 420. The driving gear 431 and driven gear 432 are made of wear-resistant stainless steel or high-strength conductive material and are connected to the slow-release control plate 420 to adjust the release rate. The gear transmission between driving gear 431 and driven gear 432 ensures that the slow-release control plate 420 can rotate smoothly, switching between different penetration rates with each 90-degree rotation. In addition, the positions of the driving gear 431 and the driven gear 432 correspond to each other, which can ensure that the solution can be released evenly, prevent local concentration from being too high, and improve the absorption efficiency and consistency of the medium to be released.

[0058] In one embodiment of the present application, the release device further includes a position adjustment member 600 , which is connected to the driving gear 431 and is located on the outer surface of the release device body 100 . The position adjustment member 600 is used to drive the driving gear 431 to rotate.

[0059] You can refer to Figure 2 A position adjustment member 600 is provided on the outer surface of the slow-release device body 100. This position adjustment member 600 can be connected to the driving gear 431. The user can operate the position adjustment member 600 to drive the driving gear 431 to rotate. The driving gear 431 rotates, which in turn drives the driven gear 432 to rotate, thereby adjusting the position of the slow-release control plate 420. In one example, the position adjustment member 600 can be a mechanical button that drives the driving gear 431 to rotate. For example, a single press of the mechanical button causes the driving gear 431 to rotate, ultimately rotating the release control plate 90 degrees, allowing permeation pores of different pore sizes to contact the solution and adjust the release rate. The mechanical button can be made of silicone or ABS.

[0060] In one embodiment of the present application, the slow-release structure further includes: a receiving groove opposite to each group of penetration holes 410 , and the receiving groove is provided on a side of the slow-release control sheet 420 facing the slow-release device body 100 .

[0061] On the side of the slow-release control sheet 420 facing the slow-release device body 100, a receiving groove is provided, corresponding to each group of permeation holes 410. Specifically, each group of permeation holes 410 has a corresponding receiving groove. When the medium to be released flows into the permeation holes, the receiving groove and the slow-release control sheet 420 form a chamber that temporarily stores the medium to be released. Furthermore, the receiving groove corresponding to each group of permeation holes 410 effectively isolates each group of permeation holes 410. The receiving grooves independently isolate each group of permeation holes 410 from each other. When the permeation holes are in the working position, the medium to be released can only flow out through that group of permeation holes, preventing it from flowing to other groups of permeation holes, thus ensuring reliable release.

[0062] In one embodiment of the present application, the slow release device further includes a storage unit 800 for storing the medium to be released. The storage unit 800 is installed in a storage cavity. A liquid guide 120 is provided in the storage cavity. The liquid guide 120 is used to allow the medium to be released in the storage unit 800 to flow out through the release through hole 110.

[0063] The sustained-release device body 100 also includes several storage units 800, which are installed in the storage cavity. Each storage unit 800 can store a solution containing the medium to be released. Different storage units 800 can store the same solution containing the medium to be released, or different solutions containing the medium to be released. A liquid guide 120 is also provided within the storage cavity, connecting the storage units 800 to the release through-hole 110. The medium to be released in the storage units 800 flows through the release through-hole 110 and onto the conductive matrix 500 for absorption by the user.

[0064] In one embodiment of the present application, there are multiple storage cavities, and the multiple storage cavities are arranged at intervals; each storage cavity in the multiple storage cavities is connected to one group of the multiple groups of permeation holes; and the storage unit 800 is arranged in a corresponding storage cavity in the multiple storage cavities.

[0065] The number of storage cavities corresponds to the number of storage units 800. Each storage unit 800 is arranged in a corresponding storage cavity among the multiple storage cavities, that is, each storage unit 800 can be arranged in a storage cavity corresponding to it, and each storage cavity is respectively connected to one group of multiple groups of permeation holes, so that the medium to be released in each storage unit 800 flows out to the corresponding storage cavity and then flows out through the corresponding permeation hole.

[0066] In one embodiment of the present application, the liquid guide member 120 is a liquid outlet needle, which includes a cylindrical needle head, and a plurality of liquid guide holes 121 are provided on the side wall of the cylindrical needle head. The liquid outlet needle is used to pierce the storage unit and connect the medium to be released in the storage unit to the release through hole 110 through the liquid guide hole 121.

[0067] The liquid guide 120 is a liquid discharge needle comprising a cylindrical needle head, the tip of which faces outward, i.e., toward the storage unit 800. When the external storage unit 800 is inserted and installed into the storage cavity, the cylindrical needle head punctures the storage unit 800. Several liquid guide holes 121 are provided on the sidewall of the cylindrical needle head. These guide holes 121 can communicate with the release through-hole 110. The medium to be released in the storage unit 800 flows through the liquid guide holes 121 into the storage cavity, and then flows through the release through-hole 110 onto the conductive matrix 500 for absorption by the user.

[0068] The storage unit 800 contains a solution containing active substances such as nicotine, pharmaceuticals, and plant extracts. Made of medical-grade plastic or soft silicone, it offers excellent sealing and corrosion resistance. Users can select different storage units 800 to insert into the storage cavity as needed, allowing the sustained-release device to absorb different active substances, improving its practicality.

[0069] In one embodiment of the present application, the slow release device further includes: an electric field adjustment member 700 in communication with the first electrode 200 and the second electrode 300 , for adjusting the electric field strength between the first electrode 200 and the second electrode 300 .

[0070] The sustained-release device body 100 may also be provided with an electric field adjustment member 700 connected to the first electrode 200 and the second electrode 300. The electric field adjustment member 700 is used to adjust the battery strength between the first electrode 200 and the second electrode 300. By adjusting the electric field strength of ion introduction, the transdermal absorption rate can be further accurately controlled to meet the personalized needs of different users.

[0071] In one example of the present application, the releaser body 100 can be made of ABS engineering plastic, so that the releaser body 100 has the characteristics of toughness, hardness, and rigidity, high impact strength, excellent wear resistance, good dimensional stability, strong oil resistance, excellent electrical insulation, little influence by temperature, humidity, and frequency, and good tolerance, which can withstand the medium to be released. It is also colorless, odorless, and non-toxic, allowing the releaser body 100 to be used for a long time. Among them, ABS engineering plastic is acrylonitrile-butadiene-styrene copolymer, which is a thermoplastic engineering plastic produced by copolymerization of three monomers: acrylonitrile (A), butadiene (B), and styrene (S). Its composition ratio can be adjusted according to needs, and the typical formula is 25%-35% acrylonitrile, 25%-30% butadiene, and 40%-50% styrene. The size of the slow-release device body 100 can be set to the size of a nicotine patch product, so that the slow-release device body 100 has the characteristics of being lightweight and durable, which is convenient for users to carry and can be used at any time according to needs, thereby improving the practicality of the slow-release device.

[0072] In summary, using nicotine as the medium to be released as an example, the use of the sustained-release device is described as follows: the user first selects the appropriate storage unit 800 and inserts it into the storage slot of the sustained-release device body 100, then adheres the conductive matrix 500 to the appropriate part of the skin (such as the arm or neck). Pressing the position adjustment member 600, the sustained-release control plate 420 is rotated and adjusted to the desired release rate via the driving gear 431. Each 90-degree rotation switches to a different aperture or closes the release channel. After the sustained-release device is turned on, the nicotine solution in the storage unit 800 is released to the surface of the conductive matrix 500 through the liquid guide member 120. Under the action of the first electrode 200 and the second electrode 300 for ion introduction, the nicotine ions pass through the skin barrier and enter the blood circulation. The user can further adjust the electric field strength of the first electrode 200 and the second electrode 300 through the electric field adjustment member 700 to optimize the transdermal absorption efficiency. After use, the sustained-release control plate 420 can be rotated to the fully closed area to stop release, and the device can be removed to clean the skin surface.

[0073] This embodiment of the present application significantly increases the transdermal absorption rate of the released medium by combining iontophoresis technology with precise regulation of the sustained-release control sheet 420, resulting in a rapid onset of action and stable release, enabling a faster and more controllable delivery method. Users can select different concentrations of storage units 800 according to their needs and flexibly adjust the release rate and transdermal absorption efficiency to meet their individual needs.

[0074] Correspondingly, for the above slow release device, the embodiment of the present application also discloses a control method for the slow release device. Figure 3 As shown, the control method of the slow release device may specifically include the following steps:

[0075] Step 301, determining the electric field strength and the sustained release rate based on the release control operation;

[0076] A sustained-release device can be used to wait for the release of a nicotine dose from a release medium. When using a sustained-release device, a user can determine a release control operation to adjust the release rate of the sustained-release device based on their needs. The release control operation indicates the user's intention to adjust the release rate.

[0077] When a release control operation is received, the corresponding electric field intensity and release rate are determined based on the operation amplitude, number of times, etc. of the release control operation.

[0078] In one example, the release control operation can include a first press operation for adjusting the electric field strength and a second press operation for adjusting the release rate. The magnitude of the increase or decrease in electric field strength can be determined based on the amplitude and direction of the first press operation, and the desired electric field strength can be determined by superimposing the increase or decrease on the current electric field strength. The release rate selected by the user can be determined based on the number of presses in the second press operation.

[0079] Step 302, controlling the first electrode and the second electrode to reach an electric field strength;

[0080] The first electrode and the second electrode can be controlled to achieve a target controlled battery strength, so that the current between the first electrode and the second electrode changes, thereby causing the ions of the skin patch to migrate in a directional manner, changing the permeability between the skin patch and the skin, and thereby adjusting the release rate of the substance to be released.

[0081] Step 303: Control the slow-release structure to adjust the permeation hole corresponding to the slow-release rate to be in the working position.

[0082] The sustained-release structure can also be controlled to adjust the sustained-release rate by placing the corresponding permeation holes in an operating position. This means that the medium to be released from the sustained-release device body is released into the skin patch through the corresponding permeation holes, and the release rate of the released substance is adjusted using the permeation holes. The operating position can be a predetermined width range enclosed between the contact points of the first and second electrodes on the sustained-release structure.

[0083] The embodiments of the present application determine the electric field strength and sustained release rate based on a release control operation; control the first and second electrodes to achieve the desired electric field strength; and control the sustained release structure to adjust the permeable holes corresponding to the sustained release rate to an operating position. The release rate is determined by the user's release control operation, and the release rate of the medium to be released is adjusted by adjusting the electric field strength of the first and second electrodes, thereby improving the ease of use of the sustained release device.

[0084] It should be noted that, for the above embodiments, for the sake of simplicity, they are all expressed as a series of action combinations, but those skilled in the art should be aware that the embodiments of the present application are not limited by the order of the actions described, because according to the embodiments of the present application, certain steps can be performed in other orders or simultaneously. Secondly, those skilled in the art should also be aware that the embodiments described in the specification are all preferred embodiments, and the actions involved are not necessarily required by the embodiments of the present application.

[0085] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0086] The terms "first", "second", etc. are used for descriptive purposes only and are not to be understood as suggesting or implying relative importance or implicitly indicating the number or order of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of this application, "multiple" means two or more, unless otherwise clearly and specifically defined. In addition, the terms "include", "comprises", and "has" and any variations thereof are intended to cover non-exclusive inclusions. As used in this application, the term "and / or" includes any and all combinations of one or more of the associated listed items, and the phrase "at least one of A and B" refers to only A, only B, or both A and B. It should be understood that in this specification, the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "height", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships or dimensions based on the orientations or positional relationships or dimensions shown in the accompanying drawings, and these terms are used only for the convenience of description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the scope of protection of the present disclosure.

[0087] Although preferred embodiments of the present invention have been described, those skilled in the art may make additional changes and modifications to these embodiments once they become aware of the basic inventive concepts. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the embodiments of the present invention.

[0088] Finally, it should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or terminal device that includes a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article, or terminal device. In the absence of further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of additional identical elements in the process, method, article, or terminal device that includes the element.

[0089] The above is a detailed introduction to a sustained-release device and sustained-release system provided by the present application. Specific examples are used herein to illustrate the principles and implementation methods of the present application. The description of the above embodiments is only used to help understand the method and core idea of ​​the present application. At the same time, for those skilled in the art, according to the idea of ​​the present application, there may be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as limiting the present application.

Claims

1. A sustained-release device, characterized in that: include: A slow-release device body, a first electrode, a second electrode and a slow-release structure; The slow-release device body is provided with a release through-hole and a storage cavity, the release through-hole is in communication with the storage cavity, and the storage cavity is used to store the medium to be released; the first electrode is fixed in the slow-release device body and passes through the slow-release structure; the second electrode is fixed in the slow-release device body and is connected to the slow-release structure; the slow-release structure has multiple groups of permeable holes that can be communicated with the release through-hole, wherein at least two groups of the permeable holes have different slow-release rates for the medium to be released.

2. The sustained-release device according to claim 1, characterized in that: At least two groups of permeation holes form different sustained release rates based on different effective through-hole area ratios; the effective through-hole area ratios are determined based on the single pore area and the number of pores per unit area of ​​each group of permeation holes.

3. The sustained-release device according to claim 1, characterized in that: The sustained-release structure includes a sustained-release control sheet, and the permeation hole penetrates the sustained-release control sheet.

4. The sustained-release device according to claim 3, characterized in that: The slow-release structure is rotatably arranged relative to the slow-release device body, and includes: at least two groups of permeation holes evenly distributed along the circumferential direction of the slow-release control plate and with successively increasing pore sizes; the slow-release structure can be rotated relative to the slow-release device body so that one group of the permeation holes is opposite to and connected to the release through hole.

5. The sustained-release device according to claim 3, characterized in that: The slow-release structure further includes: an adjustment component coupled to the slow-release control sheet, the adjustment component being used to adjust the relative position of the permeation hole and the slow-release through hole, wherein when the permeation hole is connected to the slow-release through hole, the permeation hole is in a working position.

6. The sustained-release device according to claim 5, characterized in that: The adjustment assembly includes: a driven tooth arranged on the outer edge of the slow-release control piece, and a driving gear engaged with the driven tooth and fixed on the slow-release device body.

7. The sustained-release device according to any one of claims 1 to 6, characterized in that: The slow release device further comprises a storage unit for storing the medium to be released. The storage unit is installed in the storage cavity. A liquid guide is provided in the storage cavity. The liquid guide is used to allow the medium to be released in the storage unit to flow out through the release through hole.

8. The sustained-release device according to claim 7, characterized in that: There are multiple storage cavities, which are arranged at intervals; each of the multiple storage cavities is connected to one of the multiple groups of permeation holes; and the storage unit is arranged in a corresponding storage cavity among the multiple storage cavities.

9. The sustained-release device according to claim 7, characterized in that: The liquid guide member is a liquid outlet needle, which includes a cylindrical needle head. A plurality of liquid guide holes are provided on the side wall of the cylindrical needle head. The liquid outlet needle is used to pierce the storage unit and connect the medium to be released in the storage unit to the release through hole through the liquid guide hole.

10. A sustained-release system, characterized in that: It comprises a porous conductive matrix and the sustained-release device according to any one of claims 1 to 9, wherein the conductive matrix is ​​attached to the side of the sustained-release structure facing away from the sustained-release device body and is used to absorb the medium to be released conducted by the permeable pores of the sustained-release structure.

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