A pharmaceutical excipient rectification apparatus

Abstract

The application provides a pharmaceutical excipient rectification equipment and belongs to the technical field of rectification towers. The rectification tower body is sequentially provided with a lower layer discharge area, a rectification area and an upper layer discharge area from bottom to top. The side wall of the rectification tower body is connected with a feeding pipe, the top is connected with an exhaust pipe and the bottom is connected with a liquid discharge pipe. A heat pump heating system is arranged to heat the liquid phase of the lower layer and then re-feed the liquid phase into the rectification equipment. The gaseous phase of the upper layer is condensed and then flows back into the rectification equipment. The rectification area is separated into a primary distillation section and a rectification section by a cylindrical separation cylinder. A cleaning assembly is arranged on the separation cylinder to clean the tray plates on the inner and outer sides. A filter assembly is arranged between the liquid discharge pipe and the heat pump heating system. The crystalline bodies in the tray plates and the through holes of the tray plates can be regularly cleaned and collected in the filter assembly, thereby avoiding the blockage of the structural pipelines in the rectification equipment.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of rectifying column, in particular to a pharmaceutical excipient rectifying equipment. BACKGROUND

[0002] In the production of pharmaceutical excipients, rectification technology is mainly used for extracting and purifying volatile liquids, organic substances with good thermal stability or solvent excipients that need to be separated at high purity.

[0003] The patent with publication number CN102872609B discloses a divided wall rectifying column. A partition plate is arranged along the longitudinal direction of the rectifying column to divide the space in the rectifying column into a top combination zone, a feed side of a divided wall zone, a discharge side of the divided wall zone and a bottom combination zone. The rectifying column further comprises a liquid middle section reflux distribution system and a tower bottom rising gas distribution control system.

[0004] However, during the separation and purification process of the rectifying column, due to the crystallization or polymerization of the medium, these substances will accumulate in the tray and pipeline, causing the blockage of the necessary structural equipment in the rectifying equipment and affecting the normal operation of the rectifying equipment. SUMMARY

[0005] In view of the above problems, the present application provides a pharmaceutical excipient rectifying equipment.

[0006] In order to achieve the above-mentioned application purpose, the technical scheme adopted by the present application is as follows:

[0007] The present application provides a pharmaceutical excipient rectifying equipment, which comprises a rectifying column body, a lower layer discharge area, a rectifying area and an upper layer discharge area are sequentially arranged in the rectifying column body from bottom to top, a feed pipe connected with the rectifying area is connected to the side wall of the rectifying column body, an exhaust pipe is connected to the top of the rectifying column body, a liquid discharge pipe is connected to the bottom of the rectifying column body, a filter assembly is connected to the liquid discharge pipe, a heat pump heating system is connected to the side of the filter assembly away from the rectifying column body, an air inlet pipe in communication with the lower layer discharge area of the rectifying column body is connected to the liquid discharge pipe after passing through the heat pump heating system, a first discharge pipe is connected to the liquid discharge pipe, a condensation system is connected to the exhaust pipe after passing through the heat pump heating system, a condensation reflux pipe in communication with the upper layer discharge area of the rectifying column body is connected to the condensation system, and a second discharge pipe is connected to the condensation reflux pipe.

[0008] A partition cylinder is coaxially arranged in the rectifying area of the rectifying column body, which divides the rectifying area of the rectifying column body into an initial distillation section on the inside and a rectifying section on the outside. A plurality of trays are arranged in the initial distillation section and the rectifying section from bottom to top. A plurality of through holes are formed in each tray. A third discharge pipe in communication with the rectifying section is connected to the outer wall of the rectifying column body.

[0009] Further, the rectifying tower body is provided with a cleaning assembly for cleaning the tower plate and the through hole, the cleaning assembly comprises a cleaning rod and a cleaning barrel, the separation barrel is coaxially arranged in the rectifying tower body, the rectifying tower body is coaxially fixedly provided with a mounting rod, the tower plate in the primary distillation section is fixedly arranged on the mounting rod, the tower plate in the rectifying section is fixedly arranged on the inner side wall of the rectifying tower body, and the rectifying tower body is provided with a first driving assembly for driving the separation barrel to rotate;

[0010] The cleaning rod is fixedly arranged on the inner side wall and the outer side wall of the separation barrel, the cleaning rod corresponds to each layer of tower plate one by one and is located above the corresponding tower plate, and the cleaning rod is provided with bristles in contact with the surface of the lower tower plate;

[0011] A plurality of cleaning barrels are arranged on the cleaning rod in the length direction of the cleaning rod, the diameter of the cleaning barrel is not greater than the diameter of the through hole, the cleaning barrel is located on one side of the bristle, the cleaning barrel is slidingly arranged on the cleaning rod in the vertical direction, and the rectifying tower body and the cleaning rod are provided with a second driving assembly for driving the cleaning barrel to ascend and descend to clean the through hole.

[0012] Further, the first driving assembly comprises a first driving motor, the first driving motor is arranged on the outer wall of the rectifying tower body, the output shaft of the first driving motor extends into the rectifying tower body and is in transmission connection with the top of the separation barrel;

[0013] The second driving assembly comprises a guide ring and a spring, the guide ring is coaxially arranged above the tower plate, the guide ring is provided with a plurality of downward guide protrusions, the guide protrusions correspond to the through holes on the tower plate one by one, the top of the cleaning barrel is rotatably provided with a roller, and the spring is used to drive the cleaning barrel to move upward so that the roller keeps rolling contact with the bottom wall of the guide ring. When the roller is aligned with the guide protrusion, the bottom end of the cleaning barrel penetrates into the through hole.

[0014] Further, the tower plates are arranged alternately in the primary distillation section and the rectifying section, one side edge of the tower plate is provided with a baffle, the other side edge is provided with an overflow plate, the baffle and the overflow plate are both provided with a first discharge port for the material to flow downward, the bottom wall of the first discharge port is flush with the top wall of the tower plate, the overflow plate and the baffle are both vertically and movably provided with a first gate for opening and closing the first discharge port, and the rectifying tower body is provided with a third driving member for driving the first gate to vertically move up and down;

[0015] The third driving member comprises a first connecting frame, a second connecting frame, a first driving push rod and a second driving push rod, the first connecting frame is fixedly connected with each first gate in the primary distillation section, the first driving push rod is fixedly arranged on the rectifying tower body and is used to drive the first connecting frame to vertically move, the second connecting frame is fixedly connected with each first gate in the rectifying section, and the second driving push rod is fixedly arranged on the rectifying tower body and is used to drive the second connecting frame to vertically move.

[0016] Further, the rectifying tower body is provided with a liquid distribution groove in the upper layer discharge area, the condensing reflux pipe is connected with the liquid distribution groove, two second discharge outlets are respectively arranged on both sides of the liquid distribution groove and face the initial distillation section and the rectifying section, a second gate for opening and closing the two second discharge outlets is vertically arranged on the liquid distribution groove, and the rectifying tower body is provided with a fourth driving member for independently driving the two second gates to vertically move.

[0017] The fourth driving member comprises a third driving push rod and a fourth driving push rod, both of which are fixedly arranged on the rectifying tower body, and the third driving push rod and the fourth driving push rod respectively drive the second gates close to the initial distillation section and the rectifying section on the liquid distribution groove to move.

[0018] Further, a support plate is arranged between the lower layer discharge area and the rectifying section in the rectifying tower body, the bottom end of the partition cylinder is rotatably connected to the support plate, a plurality of flow guide grooves are arranged on the support plate, a clearance hole is arranged in the bottom of the flow guide groove, a plurality of liquid passing holes are arranged in the inner wall of the flow guide groove, a shielding cylinder with the same inner diameter as the clearance hole is coaxially arranged in the flow guide groove, a first mounting plate corresponding to the initial distillation section and a second mounting plate corresponding to the rectifying section are vertically arranged below the support plate, a gas permeation cylinder with a size matching the shielding cylinder is fixedly arranged on the first mounting plate and the second mounting plate, a strip-shaped gas permeation hole is vertically arranged on the outer wall of the gas permeation cylinder, the gas permeation hole extending out of the top of the shielding cylinder connects the upper and lower parts of the support plate, a gas distribution cylinder is arranged in the lower layer discharge area, a gas inlet pipe is connected to the gas distribution cylinder, a plurality of branch pipes are connected to the gas distribution cylinder, the top end of the branch pipe is open and vertically slidably arranged in the gas permeation cylinder, and a fifth driving member for independently driving the first mounting plate and the second mounting plate to move is arranged on the rectifying tower body.

[0019] The fifth driving member comprises a fifth driving push rod and a sixth driving push rod, the fifth driving push rod is fixedly arranged on the rectifying tower body and used for driving the first mounting plate to vertically move, and the sixth driving push rod is fixedly arranged on the rectifying tower body and used for driving the second mounting plate to vertically move.

[0020] Further, the heat pump heating system comprises a compressor and a reboiler, the reboiler has a first heat exchange channel and a second heat exchange channel spaced from each other, the inlet of the compressor is communicated with the exhaust pipe at the top of the rectifying tower body, the outlet of the compressor is communicated with the inlet of the first heat exchange channel, the outlet of the first heat exchange channel is connected with the condensing system, one end of the second heat exchange channel of the reboiler is connected with the liquid discharge pipe, and the other end is connected with the gas inlet pipe.

[0021] Further, the condensing system comprises a pressure reducing valve and a cooler, the inlet of the cooler is connected with the pressure reducing valve, the outlet of the first heat exchange channel is sequentially connected with the pressure reducing valve and the cooler, and the outlet of the cooler is connected with the condensing reflux pipe.

[0022] Further, the filtering assembly comprises a filtering tank, the top and bottom of the filtering tank are respectively provided with an inlet and a residue discharge port, an outlet is connected to the sidewall of the filtering tank, the inlet and the outlet of the filtering tank are both connected to the liquid discharge pipe, a filter cartridge is coaxially arranged in the filtering tank, the outlet and the inlet of the filtering tank and the residue discharge port are separated by the filter cartridge, a valve is arranged at the residue discharge port and detachably connected to a residue collecting tank.

[0023] Further, a third connecting frame is coaxially and rotatably arranged in the filtering tank, the third connecting frame is annular, a cleaning roller is rotatably arranged on the third connecting frame, brush hairs in contact with the outer wall of the filter cartridge are arranged on the outer wall of the cleaning roller, a second driving motor is arranged on the outer wall of the filtering tank, the output shaft of the second driving motor extends into the filtering tank and is in mesh transmission with the third connecting frame.

[0024] The beneficial effects of the present application are: 1. The rotating separation cartridge is used as the separation component of the divided wall rectification equipment, and the separation cartridge is used as the installation basis of the cleaning assembly on the column plate, so that the column plate and the through hole on the column plate on the inner and outer sides of the separation cartridge can be effectively cleaned, the cleaned crystalline bodies on the column plate can be conveniently and effectively discharged, the liquid phase in the rectification tower is filtered by the filtering assembly, the impurities of the crystalline bodies in the liquid phase are concentrated and collected, and the blockage of the necessary structural equipment in the rectification equipment is effectively avoided;

[0025] 2. The liquid distribution groove is combined with the second gate with adjustable opening degree to control the liquid phase flow ratio in the primary distillation section and the rectification section, the gas separation cartridge is combined with the gas permeation cylinder with adjustable height extending into the rectification section, the gas phase flow ratio in the primary distillation section and the rectification section can be controlled, and the separation and purification process requirements of different components are met;

[0026] 3. The primary distillation section and the rectification section are in the form of a cylinder, compared with the traditional divided wall rectification tower, the flow length of the liquid phase on each column plate in the rectification section is prolonged, the liquid phase temperature on each column plate in the rectification section is obviously decreased in turn, and the separation precision of the intermediate component is improved;

[0027] 4. The heat pump heating system is used to heat the liquid phase in the lower discharge area, compared with the traditional steam heating method, the energy consumption is low, and the energy saving and environmental protection are achieved. BRIEF DESCRIPTION OF DRAWINGS

[0028] Figure 1 It is a whole structure schematic view of the pharmaceutical auxiliary material rectification equipment of the embodiment of the present application.

[0029] Figure 2 It is an internal structure schematic view of the rectification tower body of the embodiment of the present application.

[0030] Figure 3 It is an internal structure schematic view of the primary distillation section of the embodiment of the present application.

[0031] Figure 4The internal structure schematic diagram of the rectification section of the embodiment of the present application.

[0032] Figure 5 The Figure 2 The partial structure schematic diagram of the cleaning assembly in section A.

[0033] Figure 6 The Figure 2 The partial sectional structure schematic diagram of the flow guide groove, the shielding cylinder, the air permeation cylinder and the gas distribution cylinder on the support plate in section B.

[0034] Figure 7 The structure schematic diagram of the filtering assembly of the embodiment of the present application.

[0035] 1, rectification tower body; 11, lower layer discharge area; 121, initial distillation section; 122, rectification section; 13, upper layer discharge area; 14, feeding pipe; 15, exhaust pipe; 151, condensation reflux pipe; 152, second discharge pipe; 16, liquid discharge pipe; 161, first discharge pipe; 162, air inlet pipe; 17, third discharge pipe; 18, mounting rod; 2, filtering assembly; 21, filtering tank; 22, filter cylinder; 23, slag collecting tank; 24, third connecting frame; 241, cleaning roller; 242, second driving motor; 31, compressor; 32, reboiler; 41, pressure reducing valve; 42, cooler; 5, separation cylinder; 6, tower plate; 61, through hole; 62, baffle; 63, overflow plate; 64, first discharge outlet; 65, first gate; 651, first connecting frame; 652, second connecting frame; 653, first driving push rod; 654, second driving push rod; 71, cleaning rod; 72, cleaning cylinder; 721, roller; 73, first driving motor; 74, guide ring; 741, guide protrusion; 75, spring; 8, liquid distribution groove; 81, second discharge outlet; 82, second gate; 83, third driving push rod; 84, fourth driving push rod; 9, support plate; 91, flow guide groove; 92, clearance hole; 921, liquid passage; 93, shielding cylinder; 94, first mounting plate; 941, fifth driving push rod; 95, second mounting plate; 951, sixth driving push rod; 96, air permeation cylinder; 961, air permeation hole; 97, gas distribution cylinder; 971, branch pipe. DETAILED DESCRIPTION

[0036] In order to better understand the above technical solutions, the above technical solutions will be described in detail below in combination with the drawings of the specification and specific embodiments.

[0037] The embodiment of the present application discloses a pharmaceutical excipient rectification equipment, which refers to Figure 1 , Figure 2 , Figure 3 and Figure 4, including rectification tower body 1, rectification tower body 1 in the lower layer discharge area 11, rectification zone and upper layer discharge area 13 are sequentially provided from bottom to top, the side wall of rectification tower body 1 is connected with the feed pipe 14 connected with rectification zone, the top of rectification tower body 1 is connected with exhaust pipe 15, the bottom of rectification tower body 1 is connected with liquid discharge pipe 16, filter assembly 2 is connected with liquid discharge pipe 16, heat pump heating system is connected on the side of liquid discharge pipe 16 away from the body of rectification tower of filter assembly 2, liquid discharge pipe 16 is connected with the gas inlet pipe 162 communicated with the lower layer discharge area 11 of rectification tower body 1 after passing through heat pump heating system. First discharge pipe 161 is connected on the liquid discharge pipe 16, exhaust pipe 15 is connected with condensing system after passing through heat pump heating system, condensing system is connected with condensing reflux pipe 151 communicated with the upper layer discharge area 13 of rectification tower body 1, second discharge pipe 152 is connected on condensing reflux pipe 151. A plurality of layers of trays 6 are provided in rectification zone from bottom to top, a plurality of through holes 61 are provided on each layer of tray 6.

[0038] In the operation of rectification equipment, material enters rectification zone from feed pipe 14, enters condensing system from exhaust pipe 15, condenses and returns to rectification tower body 1, and then flows through each layer of tray 6 in turn, and then collects in lower layer discharge area 11, then heat pump heating system starts, the liquid phase collected in lower layer discharge area 11 enters heat pump heating system from liquid discharge pipe 16, the gas discharged from exhaust pipe 15 is heated and pressurized again after passing through heat pump heating system, and then exchanges heat with the liquid phase in liquid discharge pipe 16, and then the liquid phase is heated and pressurized to gas, and then discharged into lower layer discharge area 11, and then the gas passes through the through holes 61 on each layer of tray 6 in turn, to realize rectification of the material. Part of the liquid phase in the liquid phase obtained by condensing in condensing reflux pipe 151 is discharged through second discharge pipe 152, to obtain the first component separated and purified. Part of the liquid phase discharged from liquid discharge pipe 16 to heat pump heating system is discharged from first discharge pipe 161, to obtain the second component separated and purified.

[0039] In the embodiment of the present application, the distillation column body 1 is coaxially provided with a partitioning cylinder 5 in the distillation zone, and the distillation zone of the distillation column body 1 is divided into an initial distillation section 121 on the inner side and a distillation section 122 on the outer side by the partitioning cylinder 5. A plurality of layers of trays 6 are arranged downward and upward in the initial distillation section 121 and the distillation section 122, and the trays 6 in the initial distillation section 121 and the distillation section 122 are arranged along the circumferential direction of the distillation column body 1. The initial distillation section 121 is connected to the feed pipe 14, and the distillation section 122 is connected to the third discharge pipe 17 on the outer wall of the distillation column body 1. The partitioning cylinder 5 forms a partitioned structure in the distillation column body 1, and the third component is separated and purified by the third discharge pipe 17. The area ratio of the trays 6 in the initial distillation section 121 and the distillation section 122 can be customized according to process requirements. The liquid phase flows along the circumferential direction on the trays 6. In the initial distillation section 121, the liquid phase flows through a short path on the trays 6, so that the condensed reflux liquid phase can quickly flow into the lower discharge area 11. In the distillation section 122, the liquid phase flows through a long path on the trays 6, so that the reboiling steam can fully contact the liquid phase. The temperature on each layer of trays 6 in the distillation section 122 changes significantly in sequence, which improves the purification effect and accurately controls the output of the third component. The heat pump heating system reduces the energy consumption in the distillation and purification process, and the partitioning cylinder 5 realizes the simultaneous obtaining of three high-purity products in a single column.

[0040] Referring to Figure 5 In order to keep the surface of the tray 6 and the inner wall of the through hole 61 in the distillation column body 1 clean, avoid the deposition of crystalline bodies in the liquid phase on the surface of the tray 6 and block the through hole 61, and affect the normal operation of the distillation equipment, a cleaning assembly for cleaning the tray 6 and the through hole 61 is arranged in the distillation column body 1 in the embodiment of the present application. In the embodiment of the present application, a mounting rod 18 is coaxially and fixedly arranged in the distillation column body 1, the tray 6 in the initial distillation section 121 of the distillation column body 1 is fixedly arranged on the mounting rod 18, and the tray 6 in the distillation section 122 is fixedly arranged on the inner side wall of the distillation column body 1. The partitioning cylinder 5 is coaxially and rotatably arranged in the distillation column body 1, and a first driving assembly for driving the partitioning cylinder 5 to reciprocatingly rotate is arranged on the distillation column body 1. The first driving assembly can adopt a first driving motor 73, which is fixedly arranged on the outer wall of the distillation column body 1 by bolts, and the output shaft of the first driving motor 73 extends into the distillation column body 1 and is in transmission connection with the top of the partitioning cylinder 5. Specifically, a bevel gear is coaxially and fixedly connected to the output shaft of the first driving motor 73, and a bevel gear ring is coaxially and fixedly arranged on the top of the partitioning cylinder 5. The bevel gear is in meshing connection with the bevel gear ring, so that the first driving motor 73 drives the partitioning cylinder 5 to reciprocatingly rotate.

[0041] The cleaning assembly can be a cleaning rod 71 and a cleaning cylinder 72. The cleaning rod 71 is fixedly arranged on the inner side wall and the outer side wall of the partition cylinder 5, and the cleaning rod 71 corresponds to each layer of the tray plate 6 and is located above the corresponding tray plate 6. The cleaning rod 71 is provided with a brush on the surface of the lower tray plate 6. A plurality of cleaning cylinders 72 are arranged on the cleaning rod 71 along the length direction of the cleaning rod 71. The cleaning cylinder 72 is located on one side of the brush. The cleaning cylinder 72 is vertically slidably arranged on the cleaning rod 71. The diameter of the cleaning cylinder 72 is not greater than the diameter of the through hole 61. The rectifying tower body 1 and the cleaning rod 71 are provided with a second driving assembly for driving the cleaning cylinder 72 to ascend and descend to clean the through hole 61. The second driving assembly can be a moving element including a guide ring 74 and a spring 75. The guide ring 74 is coaxially arranged above the tray plate 6. Specifically, the guide ring 74 can be fixed on the bottom of the other tray plate 6 above the corresponding tray plate 6 or fixed on the mounting rod 18 and the inner wall of the rectifying tower body 1. The guide ring 74 is provided with a plurality of downward guide protrusions 741 corresponding to the through hole 61 on the tray plate 6. The top of the cleaning cylinder 72 is rotatably provided with a roller 721. The spring 75 is sleeved on the cleaning cylinder 72. One end of the spring 75 is fixedly connected with the cleaning rod 71, and the other end is fixedly connected with the cleaning cylinder 72. The spring 75 is used for driving the cleaning cylinder 72 to move upward so that the roller 721 keeps rolling contact with the bottom wall of the guide ring 74. When the roller 721 is aligned with the guide protrusion 741, the bottom end of the cleaning cylinder 72 penetrates into the through hole 61.

[0042] When the first driving motor 73 drives the partition cylinder 5 to rotate, the cleaning rods 71 on the inner and outer sides of the partition cylinder 5 move on the tray plate 6 to clean the crystalline body on the surface of the tray plate 6. Through the repositioning of each cleaning rod 71 on the partition cylinder 5, the cleaning rod 71 can simultaneously approach one side edge of the corresponding tray plate 6. During the rotation of the partition cylinder 5, each cleaning rod 71 can move from one end to the other end of the corresponding tray plate 6, thereby synchronously realizing the cleaning work of each tray plate 6. During the movement of the cleaning rod 71, the roller 721 on the cleaning cylinder 72 keeps rolling contact with the bottom wall of the guide ring 74. When the roller 721 moves to the guide protrusion 741, the cleaning cylinder 72 is driven to extend into the through hole 61 under the guidance and pushing of the guide protrusion 741. The cleaning cylinder 72 cooperates with the through hole 61 to dredge the inner wall of the through hole 61, thereby keeping the through hole 61 on the tray plate 6 working smoothly.

[0043] In the embodiment of the present application, the trays 6 are staggered in the primary distillation section 121 and the rectification section 122, and the edge plates are fixed to the edges of the trays 6 close to the partitioning cylinder 5. The one side edge of the tray 6 is provided with the baffle 62, and the other side edge is provided with the overflow plate 63. The height of the baffle 62 is higher than that of the overflow plate 63. The liquid phase on the tray 6 flows to the lower tray 6 through the overflow plate 63. The first discharge port 64 for downward flow of the material is arranged on the baffle 62 and the overflow plate 63. The bottom wall of the first discharge port 64 is flush with the top wall of the tray 6. The first gate 65 for opening and closing the first discharge port 64 is vertically arranged on the baffle 62 and the overflow plate 63. The third driving member for vertically driving the first gate 65 is arranged on the rectification tower body 1. By periodically driving the first gate 65 to rise and open the first discharge port 64, the cleaning rod 71 can clean the crystalline on the tray 6 to the edges of the tray 6. The crystalline is discharged to the lower layer with the liquid phase from the first discharge port 64, so that the crystalline is not accumulated in the corner of the edge of the tray 6, and the cleaning effect of the tray 6 is improved.

[0044] In the embodiment of the present application, the trays 6 are staggered in the primary distillation section 121 and the rectification section 122, and the edge plates are fixed to the edges of the trays 6 close to the partitioning cylinder 5. The one side edge of the tray 6 is provided with the baffle 62, and the other side edge is provided with the overflow plate 63. The height of the baffle 62 is higher than that of the overflow plate 63. The liquid phase on the tray 6 flows to the lower tray 6 through the overflow plate 63. The first discharge port 64 for downward flow of the material is arranged on the baffle 62 and the overflow plate 63. The bottom wall of the first discharge port 64 is flush with the top wall of the tray 6. The first gate 65 for opening and closing the first discharge port 64 is vertically arranged on the baffle 62 and the overflow plate 63. The third driving member for vertically driving the first gate 65 is arranged on the rectification tower body 1. By periodically driving the first gate 65 to rise and open the first discharge port 64, the cleaning rod 71 can clean the crystalline on the tray 6 to the edges of the tray 6. The crystalline is not accumulated in the corner of the edge of the tray 6, and the cleaning effect of the tray 6 is improved.

[0045] In the embodiment of the present application, the liquid distribution trough 8 is arranged in the upper layer discharge area 13 in the rectifying tower body 1, the liquid distribution trough 8 is arranged above the partition cylinder 5, and the condensate reflux pipe 151 is connected to the liquid distribution trough 8. Two second discharge outlets 81 are respectively arranged on the two sides of the liquid distribution trough 8 and face the primary distillation section 121 and the rectifying section 122, and a second gate 82 for opening and closing the two second discharge outlets 81 is vertically arranged on the liquid distribution trough 8. The rectifying tower body 1 is provided with a fourth driving member for independently driving the vertical lifting of the two second gates 82. The fourth driving member can be a third driving push rod 83 and a fourth driving push rod 84. The third driving push rod 83 and the fourth driving push rod 84 are both fixedly installed on the rectifying tower body 1 by bolts. The output sections of the third driving push rod 83 and the fourth driving push rod 84 both extend into the rectifying tower body 1 and are fixedly connected to the two second gates 82 on the liquid distribution trough 8 near the primary distillation section 121 and near the rectifying section 122 respectively. The third driving push rod 83 and the fourth driving push rod 84 independently drive the lifting of the two second gates 82 on the liquid distribution trough 8. The extension amount of the output end of the third driving push rod 83 and the fourth driving push rod 84 is accurately controlled by a computer. By controlling the opening degree of the two second discharge outlets 81, the flow distribution ratio of the condensate reflux liquid phase entering the primary distillation section 121 and the rectifying section 122 is controlled.

[0046] With reference to Figure 6 Further, the support plate 9 is arranged between the lower layer discharge area 11 and the rectifying area in the rectifying tower body 1. The bottom end of the partition cylinder 5 is rotationally connected to the support plate 9. The support plate 9 is provided with a plurality of flow guide grooves 91. The bottom of each flow guide groove 91 is provided with a clearance hole 92. A plurality of liquid passing holes 921 are arranged in the inner wall of each flow guide groove 91. A shielding cylinder 93 is coaxially fixed to the inner bottom wall of each flow guide groove 91. The inner diameter of the shielding cylinder 93 is consistent with the inner diameter of the liquid passing hole 921. A plurality of flow guide grooves 91 are arranged in the projection range of the primary distillation section 121 and the rectifying section 122 on the support plate 9. The flow guide grooves 91 can receive the liquid phase flowing down from the upper tower plate 6 and supply the liquid phase from the rectifying area to the lower layer discharge area 11. The first mounting plate 94 corresponding to the primary distillation section 121 and the second mounting plate 95 corresponding to the rectifying section 122 are vertically arranged below the support plate. The first mounting plate 94 and the second mounting plate 95 are both fixedly provided with a gas permeation cylinder 96 with a size matching that of the shielding cylinder 93. The gas permeation cylinder 96 is vertically provided with a strip-shaped gas permeation hole 961. The gas permeation cylinder 96 is slidingly arranged in the shielding cylinder 93. The gas permeation hole 961 on the gas permeation cylinder 96 is shielded by the shielding cylinder 93. The fifth driving member is arranged on the rectifying tower body 1 for independently driving the lifting of the first mounting plate 94 and the second mounting plate 95. The fifth driving member independently drives the first mounting plate 94 and / or the second mounting plate 95 to ascend, so that the gas permeation hole 961 extends from the top of the shielding cylinder 93, thereby connecting the rectifying area and the lower layer discharge area 11.

[0047] The fifth driving member can be a fifth driving push rod 941 and a sixth driving push rod 951, the fifth driving push rod 941 is fixedly arranged on the rectifying tower body 1 and used for driving the first mounting plate 94 to vertically move, and the sixth driving push rod 951 is fixedly arranged on the rectifying tower body 1 and used for driving the second mounting plate 95 to vertically move. A gas distribution cylinder 97 is arranged in the lower layer discharge area 11, the gas inlet pipe 162 is connected with the gas distribution cylinder 97, a plurality of branch pipes 971 are connected with the gas distribution cylinder 97, the top ends of the branch pipes 971 are open and vertically slide through the gas permeation cylinder 96. By adjusting the length of the gas permeation hole 961 extending out of the shielding cylinder 93, the distribution of the gas phase entering from the gas inlet pipe 162 in the initial distillation section 121 and the rectifying section 122 can be realized, and the purification and separation needs of different components can be met. The first driving push rod 653, the second driving push rod 654, the third driving push rod 83, the fourth driving push rod 84, the fifth driving push rod 941 and the sixth driving push rod 951 can all be electric push rods, and the extension lengths of the output rods can be precisely adjusted.

[0048] In the embodiment of the present application, the heat pump heating system comprises a compressor 31 and a reboiler 32, the reboiler 32 has a first heat exchange channel and a second heat exchange channel which are spaced from each other, the inlet of the compressor 31 is communicated with the gas discharge pipe 15 at the top of the rectifying tower body 1, the outlet is communicated with the inlet of the first heat exchange channel, the outlet of the first heat exchange channel is connected with a condensing system, one end of the second heat exchange channel of the reboiler 32 is connected with the liquid discharge pipe 16, and the other end is connected with the gas inlet pipe 162. The gas phase discharged from the gas discharge pipe 15 is pressurized and increased in temperature by the compressor 31, when the gas enters the reboiler 32, the high-temperature gas in the reboiler 32 exchanges heat with the liquid phase discharged from the liquid discharge tank, so that the liquid phase is warmed to become a gas phase and enters the lower layer discharge area 11 from the gas inlet pipe 162, thereby effectively reducing the energy consumption of the rectifying equipment during operation.

[0049] The condensing system comprises a pressure reducing valve 41 and a cooler 42, the inlet of the cooler 42 is sequentially connected with the pressure reducing valve 41 and the outlet of the first heat exchange channel, the outlet of the cooler 42 is connected with a condensing return pipe 151. After the high-temperature gas in the gas discharge pipe 15 exchanges heat in the reboiler 32, the gas enters the pressure reducing valve 41 to reduce the pressure in the pipeline, and then enters the cooler 42, the cooler 42 can be a water-cooled heat exchanger, the gas phase is condensed into a liquid phase, and enters the condensing return pipe 151 to return to the upper layer discharge area 13 or the obtained liquid phase is discharged through the second discharge pipe 152.

[0050] Referring to Figure 7The filtering assembly 2 is used to filter the crystalline bodies and impurities in the liquid phase collected from the lower discharge area 11 into the reboiler 32, so as to keep the liquid phase flowing smoothly in the rectifying device. The filtering assembly 2 comprises a filtering tank 21, the top and bottom of the filtering tank 21 are respectively provided with an inlet and a residue discharge port, and an outlet is connected to the side wall of the filtering tank 21. The inlet and the outlet of the filtering tank 21 are both connected to the liquid discharge pipe 16. A filter cylinder 22 is coaxially arranged in the filtering tank 21. The filter cylinder 22 separates the outlet from the inlet and the residue discharge port of the filtering tank 21. A residue collecting tank 23 is detachably connected to the residue discharge port of the filtering tank 21 through flanges and bolts.

[0051] Further, a third connecting frame 24 is coaxially and rotatably arranged in the filtering tank 21. The third connecting frame 24 is annular. A cleaning roller 241 is rotatably arranged on the third connecting frame 24. Brush hairs are arranged on the outer wall of the cleaning roller 241 and are in contact with the outer wall of the filter cylinder 22. A second driving motor 242 is arranged on the outer wall of the filtering tank 21. The output shaft of the second driving motor 242 extends into the filtering tank 21 and is in meshing transmission with the third connecting frame 24. Specifically, a gear ring is coaxially arranged on the third connecting frame 24. The output shaft of the second driving motor 242 extends into the filtering tank 21 and is coaxially connected with a gear wheel. The gear wheel is in meshing transmission with the gear ring.

[0052] When the third connecting frame 24 rotates, the cleaning roller 241 walks along the circumference of the filter cylinder 22. The brush hairs of the cleaning roller 241 are embedded into the filter holes on the outer wall of the filter cylinder 22, and push the blocked crystalline bodies in the filter holes into the filtering tank 21, so that the crystalline bodies can sink to the bottom and be collected into the residue collecting tank 23. The brush hairs on the cleaning roller 241 are continuously embedded into the outer wall of the filter cylinder 22, so that the cleaning roller 241 can roll and walk on the outer wall of the filter cylinder 22 during the rotation of the third connecting frame 24. The filtering function of the filter cylinder 22 can be maintained for a long time. In other embodiments, a valve can be arranged at the residue discharge port of the filter cylinder 22. The residue collecting tank 23 and the filter cylinder 22 are separated by the valve. After the valve is closed regularly, the residue collecting tank 23 can be detached without stopping the rectifying device, so that the impurities can be cleaned online.

[0053] Those skilled in the art will appreciate that, although the preferred embodiments of the present application have been described, additional changes and modifications can be made to these embodiments by those skilled in the art once they learn of the basic inventive concepts. Therefore, the appended claims are intended to include within their scope all such changes and modifications as are within the spirit and scope of the present application. It will be apparent to those skilled in the art that various modifications and variations can be made to the present application without departing from the spirit or scope of the application. Thus, it is intended that the present application cover modifications and variations of this application provided they come within the scope of the appended claims and their equivalents.

Claims

1. A pharmaceutical excipient rectification apparatus, characterized by: The application relates to a distillation tower body (1) which is internally provided with a lower discharge area (11), a distillation area and an upper discharge area (13) from bottom to top in sequence, a feeding pipe (14) connected with the distillation area is arranged on the side wall of the distillation tower body (1), an exhaust pipe (15) is arranged on the top of the distillation tower body (1), a liquid discharge pipe (16) is arranged on the bottom of the distillation tower body (1), a filtering assembly (2) is arranged on the liquid discharge pipe (16), a heat pump heating system is arranged on the side of the liquid discharge pipe (16) away from the distillation tower body (1), the liquid discharge pipe (16) is connected with a gas feeding pipe (162) in communication with the lower discharge area (11) of the distillation tower body (1) after passing through the heat pump heating system, a first discharge pipe (161) is arranged on the liquid discharge pipe (16), the exhaust pipe (15) is connected with a condensing system after passing through the heat pump heating system, the condensing system is connected with a condensing backflow pipe (151) in communication with the upper discharge area (13) of the distillation tower body (1), and a second discharge pipe (152) is arranged on the condensing backflow pipe (151). A separation cylinder (5) is coaxially arranged in the distillation area of the distillation tower body (1), the distillation area of the distillation tower body (1) is divided into an initial distillation section (121) on the inner side and a distillation section (122) on the outer side through the separation cylinder (5), a plurality of tower plates (6) are arranged in the initial distillation section (121) and the distillation section (122) from bottom to top in intervals, a plurality of through holes (61) are arranged on each tower plate (6), and a third discharge pipe (17) in communication with the distillation section (122) is arranged on the outer wall of the distillation tower body (1). A cleaning assembly for cleaning the tower plates (6) and the through holes (61) is arranged in the distillation tower body (1), the cleaning assembly comprises a cleaning rod (71) and a cleaning cylinder (72), the separation cylinder (5) is coaxially arranged in the distillation tower body (1), an installation rod (18) is fixedly arranged in the distillation tower body (1) in a coaxial mode, the tower plates (6) in the initial distillation section (121) are fixedly arranged on the installation rod (18), the tower plates (6) in the distillation section (122) are fixedly arranged on the inner wall of the distillation tower body (1), and a first driving assembly for driving the separation cylinder (5) to rotate is arranged on the distillation tower body (1). The cleaning rod (71) is fixedly arranged on the inner wall and the outer wall of the separation cylinder (5), the cleaning rod (71) corresponds to each tower plate (6) and is located above the corresponding tower plate (6), brush hairs in contact with the surface of the lower tower plate (6) are arranged on the cleaning rod (71), a plurality of cleaning cylinders (72) are arranged on the cleaning rod (71) in intervals along the length direction of the cleaning rod (71), the diameter of the cleaning cylinder (72) is not greater than that of the through hole (61), the cleaning cylinder (72) is located on the side of the brush hairs, the cleaning cylinder (72) is slidingly arranged on the cleaning rod (71) in the vertical direction, and a second driving assembly for driving the cleaning cylinder (72) to ascend and descend to clean the through hole (61) is arranged on the distillation tower body (1) and the cleaning rod (71). The first driving assembly comprises a first driving motor (73) arranged on the outer wall of the rectifying tower body (1), the output shaft of the first driving motor (73) extends into the rectifying tower body (1) and is in transmission connection with the top of the partition cylinder (5), the second driving assembly comprises a guide ring (74) and a spring (75), the guide ring (74) is coaxially arranged above the tray (6), a plurality of downward guide protrusions (741) are arranged on the guide ring (74), the guide protrusions (741) correspond to the through holes (61) on the tray (6) one by one, the top of the cleaning cylinder (72) is rotatably provided with a roller (721), the spring (75) is used for driving the cleaning cylinder (72) to move upwards so that the roller (721) keeps rolling contact with the bottom wall of the guide ring (74), when the roller (721) is aligned with the guide protrusion (741), the bottom end of the cleaning cylinder (72) penetrates into the through hole (61).

2. A pharmaceutical excipient rectifying apparatus according to claim 1, wherein The tray (6) is arranged in the primary distillation section (121) and the rectification section (122) alternately, one side edge of the tray (6) is provided with a baffle (62), and the other side edge is provided with an overflow plate (63), the baffle (62) and the overflow plate (63) are both provided with a first discharge port (64) for the material to flow downward, the bottom wall of the first discharge port (64) is flush with the top wall of the tray (6), the overflow plate (63) and the baffle (62) are both vertically and movably provided with a first gate (65) for opening and closing the first discharge port (64), the rectifying tower body (1) is provided with a third driving member for driving the first gate (65) to vertically move up and down; The third driving member comprises a first connecting frame (651), a second connecting frame (652), a first driving push rod (653) and a second driving push rod (654), the first connecting frame (651) is fixedly connected with each first gate (65) in the primary distillation section (121), the first driving push rod (653) is fixedly arranged on the rectifying tower body (1) and is used for driving the first connecting frame (651) to vertically move, the second connecting frame (652) is fixedly connected with each first gate (65) in the rectification section (122), and the second driving push rod (654) is fixedly arranged on the rectifying tower body (1) and is used for driving the second connecting frame (652) to vertically move.

3. A pharmaceutical excipient rectifying apparatus according to claim 2, wherein The rectifying tower body (1) is provided with a liquid distribution groove (8) in the upper layer discharge area (13), the condensing reflux pipe (151) is connected with the liquid distribution groove (8), two second discharge ports (81) are arranged on the two sides of the liquid distribution groove (8) and face the primary distillation section (121) and the rectification section (122), respectively, a second gate (82) for opening and closing the two second discharge ports (81) is vertically and movably arranged on the liquid distribution groove (8), and the rectifying tower body (1) is provided with a fourth driving member for independently driving the two second gates (82) to vertically move up and down; The fourth driving member includes a third driving push rod (83) and a fourth driving push rod (84), both of which are fixedly arranged on the rectifying tower body (1), and the third driving push rod (83) and the fourth driving push rod (84) drive the second gate (82) on the liquid distribution groove (8) to ascend and descend near the primary distillation section (121) and the rectification section (122) respectively.

4. The pharmaceutical excipient rectifying apparatus according to claim 1, wherein The support plate (9) is arranged between the lower discharge area (11) and the rectification area in the rectifying tower body (1), the bottom end of the separation cylinder (5) is rotationally connected to the support plate (9), a plurality of flow guide grooves (91) are arranged on the support plate (9), a clearance hole (92) is formed through the bottom of the flow guide groove (91), a plurality of liquid passing holes (921) are formed through the inner wall of the flow guide groove (91), a shielding cylinder (93) with the same inner diameter as the clearance hole (92) is coaxially fixedly arranged in the flow guide groove (91), a first mounting plate (94) corresponding to the primary distillation section and a second mounting plate (95) corresponding to the rectification section are vertically arranged below the support plate (9), the first mounting plate (94) and the second mounting plate (95) are both fixedly arranged with a gas permeation cylinder (96) with a size suitable for the shielding cylinder (93), a strip-shaped gas permeation hole (961) is vertically formed on the outer wall of the gas permeation cylinder (96), the gas permeation hole (961) extending out of the top of the shielding cylinder (93) communicates the upper and lower parts of the support plate (9), a gas distribution cylinder (97) is arranged in the lower discharge area (11), the gas inlet pipe (162) is connected to the gas distribution cylinder (97), a plurality of branch pipes (971) are connected to the gas distribution cylinder (97), the top end of the branch pipe (971) is open and vertically slidably arranged in the gas permeation cylinder (96), and the rectifying tower body (1) is provided with a fifth driving member for independently driving the first mounting plate (94) and the second mounting plate (95) to ascend and descend. The fifth driving member includes a fifth driving push rod (941) and a sixth driving push rod (951), the fifth driving push rod (941) is fixedly arranged on the rectifying tower body (1) and used for driving the first mounting plate (94) to vertically move, and the sixth driving push rod (951) is fixedly arranged on the rectifying tower body (1) and used for driving the second mounting plate (95) to vertically move.

5. The pharmaceutical excipient rectifying apparatus according to claim 1, wherein The heat pump heating system includes a compressor (31) and a reboiler (32), the reboiler (32) has a first heat exchange channel and a second heat exchange channel spaced from each other, the inlet of the compressor (31) is communicated with the exhaust pipe (15) at the top of the rectifying tower body (1), the outlet is communicated with the inlet of the first heat exchange channel, the outlet of the first heat exchange channel is connected with a condensing system, one end of the second heat exchange channel of the reboiler (32) is connected with the liquid discharge pipe (16), and the other end is connected with the gas inlet pipe (162).

6. A pharmaceutical excipient rectifying apparatus according to claim 5, wherein The condensing system comprises a pressure reducing valve (41) and a cooler (42), the inlet of the cooler (42) is connected with the pressure reducing valve (41), the outlet of the first heat exchange channel is sequentially connected with the pressure reducing valve (41) and the cooler (42), and the outlet of the cooler (42) is connected with a condensing return pipe (151).

7. The pharmaceutical excipient rectifying apparatus according to claim 1, wherein The filter assembly (2) comprises a filter tank (21), the top and bottom of the filter tank (21) are respectively provided with an inlet and a residue discharge port, and the sidewall of the filter tank (21) is connected with an outlet; the inlet and the outlet of the filter tank (21) are both connected with a liquid discharge pipe (16); a filter cylinder (22) is coaxially arranged in the filter tank (21), the outlet of the filter tank (21) is separated from the inlet and the residue discharge port by the filter cylinder (22); a valve is arranged at the residue discharge port and a residue collecting tank (23) is detachably connected.

8. A pharmaceutical excipient rectifying apparatus according to claim 7, wherein A third connecting frame (24) is coaxially and rotatably arranged in the filter tank (21), the third connecting frame (24) is annular, a cleaning roller (241) is rotatably arranged on the third connecting frame (24), brush hairs in contact with the outer wall of the filter cylinder (22) are arranged on the outer wall of the cleaning roller (241), a second driving motor (242) is arranged on the outer wall of the filter tank (21), the output shaft of the second driving motor (242) extends into the filter tank (21) and is in mesh transmission with the third connecting frame (24).

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